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Tytuł:
Effects of wheat germ agglutinin and concanavalin A on the accumulation of glycosaminoglycans in pericellular matrix of human dermal fibroblasts. A comparison with insulin.
Autorzy:
Yevdokimova, Natalia
Yefimov, Andrej
Powiązania:
https://bibliotekanauki.pl/articles/1044154.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
human dermal fibroblasts
insulin
concanavalin A
peanut agglutinin
glycosaminoglycans
wheat germ agglutinin
Opis:
The effect of insulin, wheat germ agglutinin (WGA), peanut agglutinin (PNA) and concanavalin A (ConA) on [3H]glucosamine incorporation into pericellular glycosaminoglycans (GAGs) was investigated in two lines of cultured human dermal fibroblasts. Insulin and WGA stimulated [3H]glucosamine incorporation into hyaluronic acid (HA) and heparan sulphate (HS) without any alteration of chondroitin sulphate (CS) and dermatan sulphate (DS) contents. ConA increased [3H]glucosamine incorporation into HS, CS and DS, but had no effect on [3H]glucosamine incorporation into HA. PNA affected neither the content, nor the composition of GAGs. In contrast to PNA, ConA and WGA stimulated glycolysis and demonstrated an evident antiproliferative effect on dermal fibroblasts. Thus, both the insulin-like action of WGA and ConA on cultured dermal fibroblasts and the differences between the effects of lectins on modulation of GAGs synthesis appear to be determined by their chemical structure.
Źródło:
Acta Biochimica Polonica; 2001, 48, 2; 563-572
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ethanol influence on gingival fibroblasts - a real-time in vitro study
Autorzy:
Wyganowska-Świątkowska, M.
Nowak, A.
Paszyńska, E.
Grzech-Leśniak, K.
Powiązania:
https://bibliotekanauki.pl/articles/2081937.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
alcohol
oral cavity
gingival fibroblasts
Opis:
Introduction. Alcohol consumption is the world’s third largest risk factor for disease and disability. According to the WHO report from 2011: 71% of urban respondents ty and 77% of rural respondents admit to alcohol consumption]. Lower socio-economic status and educational levels result in a greater risk of alcohol-related injury, disease and death. Alcohol is a common component of many medicines, as well as an ingredient in many oral hygiene home products. Mouthwashes containing alcohol are considered to inhibit wound healing in the oral cavity. Due to the fact that many different results are described for different concentrations of alcohol at different times, an attemptwas made to visualise the direct impact of 7.2% and 22% alcohol on human gingival fibroblasts. Materials and method. PANsystem 2000 was used for visualisation of the reaction of human gingival fibroblasts isolated from gingiva on ethanol in 2 different concentrations. PANsys 3000 is a multi-system fully-automated cell culture device used for in vitro culture and to study a variety of cell lines under conditions similar to in vivo. Observations were carried out for 48 hours since alcohol addition. Pictures were taken in a continuous process at 5 minute intervalds and combined into a film. Results. Both contamination of 7.2% and 22% ethyl alcohol negatively affected morphology and cell proliferation. Addition of ethanol at a concentration 7.2% enabled cells to regain their ability to divide and recover normal morphology after 10 hours; changes caused by 22% ethanol, however, were irreversible. Conclusions. The obtained results suggest that daily usage of 7.2% alcohol contained in mouthwashes is non-toxic for gingival fibroblasts, and could be recommended after periodontal surgery.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 647-650
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of selected flavonoids on glycosaminoglycans in human skin fibroblasts
Autorzy:
Wosek, J.
Kuźmicz, I.
Wiśniewska, R.
Nazaruk, J.
Galicka, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918304.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Fibroblasts
glycosaminoglycans
flavonoids
Opis:
Purpose: Glycosaminoglycans (GAGs) and proteoglycans (PG) in addition to collagen are the main components of extracellular matrix (ECM). They play an important role in intercellular communication and interactions between cells and ECM. The biological changes in ECM that occur during aging are induced by decrease in GAG biosynthesis. The purpose of this study was to evaluate the effect of selected flavonoids isolated from Cirsium palustre (L.) Scop. on GAG content in human skin fibroblasts. Materials and methods: Human skin fibroblasts were treated with eriodictyol 7-O-glucoside (C1), 6-hydroxyluteolin 7-O-glucoside (C2), scutellarein 7-O-glucoside (C3) and pedalitin (C4) at 1, 20 and 40 μM for 24 h. Concentration of GAGs in the medium was assayed using method based on their ability to bind the cationic dye 1,9- dimethylmethylene blue (DMMB). Results: C1, C2 and C4 at concentration of 20 and 40 µM significantly increased content of sulphated GAGs in the medium. In contrast, treatment of cells with compound C3 did not have a statistically significant impact on GAG level. Ascorbic acid used as a positive control at 50 µM showed no effect on GAG concentration and increased their content at 100 µM but to a much lower extent than flavonoids. Conclusion: Flavonoids C1, C2 and C4 showed greater than ascorbic acid stimulatory impact on GAGs in healthy human skin fibroblasts, demonstrating their therapeutic potential in the aging.
Źródło:
Progress in Health Sciences; 2016, 6(2); 59-63
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of luteolin on expression of epithelial MUC1 mucin in human skin fibroblasts
Autorzy:
Wosek, J.
Radziejewska, I.
Andrulewicz, E.
Powiązania:
https://bibliotekanauki.pl/articles/1918385.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
fibroblasts
luteolin
MUC1
Opis:
Purpose: The membrane-anchored MUC1 mucin is typically expressed on normal and cancerous epithelial cells. Non-epithelial localization of this mucin is rare. However, the presence of MUC1 in human skin fibroblasts has been recently unexpectedly revealed. The aim of the study was to prove the expression of MUC1 mucin in human skin fibroblasts and the examine of the influence of luteolin on its expression. Materials and methods: ELISA tests and real-time PCR analysis were used to assess the expression of MUC1 mucin in fibroblast cells cocultured with 30 μM concentration of luteolin. Results: The expression of MUC1 was revealed in human skin fibroblasts. Luteolin decreased the relative level of mucin in cell lysates and media. Statistically significant decreased expression of MUC1 gene after luteolin treatment of fibroblasts cells was also revealed. Conclusion: Our results prove non-epithelial localization of MUC1 mucin. Luteolin inhibits the expression of MUC1 mucin in healthy human skin fibroblasts.
Źródło:
Progress in Health Sciences; 2016, 6(2); 64-69
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the effectiveness of radio frequency (RF) treatment on improving the overall appearance of the facial skin in women – a pilot study
Ocena skuteczności zabiegu radiofrekwencji RF na poprawę ogólną wyglądu skóry twarzy u kobiet – badania pilotażowe
Autorzy:
Wilk, Monika
Lizak, Amelia
Matuła, Aleksandra
Ścisłowska-Czarnecka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1032113.pdf
Data publikacji:
2020
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
"fibroblasts"
"radio frequency (RF)"
"skin aging"
Opis:
Introduction: Aging facial skin is a natural and unavoidable process. It involves a gradual weakening of the biological activity of cells, extension of regenerative processes and reduction of adaptability. At the same time, a smooth, radiant, wrinkle-free complexion has been a global trend in cosmetology for many years, which results in more and more people, especially women, benefiting from new non-invasive anti-aging treatments. One of such treatments offered on the cosmetology market are treatments utilising RF radio waves. Therefore, the aim of this study was to assess the impact of a series of treatments utilising RF on the skin of the faces of women. Materials and methods: The analysis of the results was carried out by the examined person and by the authors of the project via a point scale of visual assessment of skin condition. The following facial skin parameters were analysed in the study: depth of wrinkles, elasticity, skin brightening and moisturising. Results and conclusions: The conducted own study proves the impact of treatments using RF radio waves on the skin of the face. The applied series of treatments caused a partial reduction of the most visible and deepest wrinkles, as well as improved elasticity, brightening and moisturising of the facial skin.
Wprowadzenie: Starzenie się skóry twarzy jest procesem naturalnym i nieuniknionym. Polega on na stopniowym słabnięciu aktywności biologicznej komórek, wydłużaniu procesów regeneracyjnych oraz obniżaniu zdolności adaptacyjnych. Jednocześnie światowym trendem w kosmetologii od wielu lat pozostaje gładka, promienista, pozbawiona zmarszczek cera co powoduje, że coraz więcej osób, a zwłaszcza kobiet, korzysta z nowych nieinwazyjnych zabiegów przeciwstarzeniowych. Jednym z takich zabiegów oferowanych na rynku kosmetologicznym są zabiegi z użyciem fal radiowych RF. Dlatego też celem niniejszej pracy była ocena wpływu serii zabiegów przy użyciu RF na skórę twarzy kobiet. Materiał i metody: Analizę wyników przeprowadzono za pomocą skali punktowej wizualnej oceny stanu skóry przez osobę badaną oraz przez autorki projektu. W badaniach analizowano następujące parametry skóry twarzy: głębokość zmarszczek, elastyczność, rozświetlenie i nawilżenie skóry. Wyniki i wnioski: Przeprowadzone badania własne dowodzą wpływu zabiegów z zastosowaniem fal radiowych RF na skórę twarzy. Zastosowana seria zabiegów spowodowało częściową redukcję najbardziej widocznych i najgłębszych zmarszczek, a także poprawę elastyczności, rozświetlenia i nawilżenia skóry twarzy.
Źródło:
Health Promotion & Physical Activity; 2020, 11, 2; 8-14
2544-9117
Pojawia się w:
Health Promotion & Physical Activity
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dried human skin fibroblasts as a new substratum for functional culture of hepatic cells
Autorzy:
Wencel, Agnieszka
Zakrzewska, Karolina
Samluk, Anna
Noszczyk, Bartłomiej
Pijanowska, Dorota
Pluta, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1038663.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cocultures
culture substratum
dried fibroblasts
human skin fibroblasts
C3A cells
Opis:
The primary hepatocytes culture is still one of the main challenges in toxicology studies in the drug discovery process, development of in vitro models to study liver function, and cell-based therapies. Isolated hepatocytes display a rapid decline in viability and liver-specific functions including albumin production, conversion of ammonia to urea, and activity of the drug metabolizing enzymes. A number of methods have been developed in order to maintain hepatocytes in their highly differentiated state in vitro. Optimization of culture conditions includes a variety of media formulations and supplements, growth surface coating with the components of extracellular matrix or with synthetic polymers, three-dimensional growth scaffolds and decellularized tissues, and coculture with other cell types required for the normal cell-cell interactions. Here we propose a new substratum for hepatic cells made by drying confluent human skin fibroblasts' culture. This growth surface coating, prepared using maximally simplified procedure, combines the advantages of the use of extracellular matrices and growth factors/cytokines secreted by the feeder layer cells. In comparison to the hepatoma cells grown on a regular tissue culture plastic, cells cultured on the dried fibroblasts were able to synthesize albumin in larger quantities and to form greater number of apical vacuoles. Unlike the coculture with the living feeder layer cells, the number of cells grown on the new substratum was not reduced after fourteen days of culture. This fact could make the dried fibroblasts coating an ideal candidate for the substrate for non-dividing human hepatocytes.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 357-363
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of a new production method of foam-like wound dressings for skin regeneration
Autorzy:
Vivcharenko, Vladyslav
Kazimierczak, Paulina
Wójcik, Michał
Przekora, Agata
Powiązania:
https://bibliotekanauki.pl/articles/284152.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
chitosan
agarose
biomaterials
fibroblasts
cytotoxicity
Opis:
Chitosan is widely used to prepare films, hydro-gels, cryogels, sponges, fibers and other various biomaterials used in the tissue engineering field. It is one of the best processable polysaccharides used in biomedicine. However, its stability is generally lower as compared with others, due to its pH sensitivity and hydrophilic character. Using chitosan in combination with agarose may not only improve chemical and mechanical properties of the resultant material (by the formation of a biocomposite), but also lead to the formation of a gel imitating physical attributes of the extracellular matrix. Moreover, the combination of these two polysaccharides has a promising ability to improve the stability of chitosan and to increase fibroblasts’ affinity to agarose. Characteristic advan-tageous features of these natural polymers raise a wide interest in tissue engineering. The aim of this study was to develop and optimize a new method to produce a highly biocompatible foam-like chitosan/agarose wound dressing for skin healing applications. The production process optimization helped to obtain the absorbent foam-like biomaterial which is non-toxic to skin fibroblasts and does not conduce their adhesion. Employing sodium bicarbonate as the main agent in the foaming reaction not only led to obtaining the foam-like structure but also neutralized the acidic pH, making the material non-toxic and non-irritating to the skin. In conclusion, the new foam-like biomaterial has great potential for biomedical applications as the wound dressing accelerating the healing process of the damaged tissues.
Źródło:
Engineering of Biomaterials; 2019, 22, 152; 16-20
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physicochemical properties and cytotoxicity of hydrogels based on Beetosan® containing sage and bee pollen
Autorzy:
Tyliszczak, Bożena
Drabczyk, Anna
Kudłacik-Kramarczyk, Sonia
Grabowska, Beata
Kędzierska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1038565.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hydrogels
cytotoxicity
fibroblasts
chitosan
sage
wettability
Opis:
Currently, increasing attention is being paid to issues related to environmental protection, waste management, as well as to the development of polymers with useful properties. The research presented here involved preparation of hydrogels based on Beetosan® - a chitosan derived from the multi-stage processing of dead bees. Moreover, hydrogels were additionally modified with natural substances - i.e. bee pollen and extract of Salvia officinalis (sage) that are well known for the presence of many compounds with beneficial properties from a medical point of view. Materials have been first obtained by photopolymerization. Then, their surface morphology, wettability and cytotoxicity to selected cell lines have been determined. It can be stated that such combination of Beetosan® hydrogel matrix and the mentioned additives resulted in a preparation of polymers characterized by negative impact on cancer cells. Impact of hydrogels with sage is slightly more intense due to the presence of substances such as ursalic or rosmaric acid that are characterized to have anticancer activity. Such negative impact has not been observed in case of studies using fibroblasts. Furthermore, addition of natural substances into hydrogels resulted in a more homogeneous surface and in the decrease of wettability angle of the tested polymers. It can be concluded that the use of natural-derived reagents and synthesis of polymers using these reagents (as a result of environmentally friendly photopolymerization) yields materials with interesting properties for medical purposes, with particular emphasis on antitumor activity, and without significant negative impact on fibroblasts.
Źródło:
Acta Biochimica Polonica; 2017, 64, 4; 709-712
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fibroblast biological activity on poly(l-lactide) and poly(l-lactide-co-trimethylene carbonate)
Autorzy:
Ścisłowska-Czarnecka, A.
Pamuła, E.
Kołaczkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/284073.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
fibroblasts
biomaterials
PLLA
Opis:
Poly-L-lactide (PLLA) is acknowledged biocompatible polyester. However, it possesses high crystallinity/brittleness/stiffness and requires long time for complete degradation. In the current study we present data on PLTMC, a copolymer of L-lactide and trimethylene carbonate (TMC). Poly(trimethylene carbonate) (PTMC) is characterised by good mechanical properties and rapid degradation rate and for this it might possess new desired features for medical applications. During the experiments, adhesion and activity of fibroblasts cultured on PLLA and PLTMC were studied and compared during two time points of 3 and 5 days. On day 3, the number of adherent fibroblasts was compromised when fibroblasts were cultured in the presence of PLTMC but the proper adherence was recovered by day 5. The same pat-tern was observed when we evaluated some activity parameters of fibroblasts. In particular, the release of proteins and nitric oxide was studied as the increased levels of the mediators might indicate unwanted inflammatory-like condition. Overall, the results suggest that the synthesized PLTMC initially shows unwanted effects on fibroblasts but with the time these effects are abolished. Therefore PLTMC seems to represent a new material that is non-cytotoxic and compatible with the living cells.
Źródło:
Engineering of Biomaterials; 2011, 14, 102; 7-10
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ biomateriałów na przyleganie i aktywność mysich fibroblastów L929
Effects of biomaterials on adhesion and activity of murine fibroblasts L929
Autorzy:
Ścisłowska-Czarnecka, A.
Pamuła, E.
Płytycz, B.
Kołaczkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/285238.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomateriały
fibroblasty
przeszczepy chirurgiczne
biomaterials
fibroblasts
transplantation
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 83-86
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of fibrin-nanocoating of nanofibrous polymer membranes on the adhesion and proliferation of human dermal fibroblasts
Autorzy:
Pajorova, J.
Bacakova, M.
Musilkova, J.
Stranska, D.
Riedel, T.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/284422.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
polymer membranes
fibroblasts
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 48
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena biozgodności bioresorbowalnych materiałów polimerowych wobec ludzkich fibroblastów
Biocompatibility of biodegradable synthetic polymers for human fibroblasts
Autorzy:
Orchel, A.
Jelonek, K.
Kasperczyk, J.
Dobrzyński, P.
Orchel, J.
Dzierżewicz, Z.
Powiązania:
https://bibliotekanauki.pl/articles/284034.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bioresorbowalne materiały polimerowe
biozgodność
fibroblasty
biodegradable synthetic polymers
biocompatibility
fibroblasts
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 5-8
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detonation nanodiamond particles modified by non-steroidal anti-inflammatory drugs in vitro examination
Autorzy:
Mitura, K.
Wilczek, P.
Niemiec-Cyganek, A.
Morenc, M.
Dudek, M.
Sobczyk-Guzenda, A.
Fraczyk, J.
Kolesińska, B.
Powiązania:
https://bibliotekanauki.pl/articles/284974.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
detonation nanodiamond particles
chemical modification
anti-inflammatory drugs
FTIR spectroscopy
mouse fibroblasts
Opis:
Most recently it has been found that nanodiamond particles have very interesting properties. There are number of research communications that detonation nanodiamond particles (NDPs) are fairly reactive and their surface can be effectively modified by chemical methods. The hydroxyl-modified NDPs were obtained by Fenton reaction, amine-functionalized NDPs were obtained by chemical reduction of the nitro- -functionalized surface and carboxyl-modified NDPs by oxidation by using H2O2 under acidic conditions. NDPs functionalized by hydroxyl- and amine- groups and amino groups were used for covalent binding of non-steroidal anti-inflammatory pharmaceuticals (aspirin, ketoprofen, ibuprofen, naproxen) via ester or amide bonds. These results of the studies proved the activity of the conjugates of active substance-NDP and study the rate of release of active substance from the NDPs surface by in vitro examinations with mouse fibroblasts. The progress of the reaction and the characteristics of the products were determined by using FT-IR. Chemical and physical structures of materials were also investigated by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). DRIFT spectra show the modification of nanodiamond by ketoprofen, naproxen, ibuprofen and aspirin.
Źródło:
Engineering of Biomaterials; 2017, 20, 140; 12-20
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Manufacturing and characterization of gellan gum – zinc oxide composites as potential biomaterials for wound treatment
Autorzy:
Macyk, Alicja
Kusibab, Anna
Pamuła, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/27324040.pdf
Data publikacji:
2023
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
gellan gum
zinc oxide nanoparticles
zinc oxide
microparticles
wound healing
L929 fibroblasts
cynk
fibroblasty
biomateriały
Opis:
This study aimed to produce gellan gum-based hydrogels with the addition of zinc oxide as a potential dressing material. Hydrogels with ZnO concentrations of 0.01%, 0.02% and 0.04% were prepared, micrometric and nanometric ZnO particles were used, and a CaCl2 crosslinker was added to one part of the samples. All samples (14 types) produced by the freeze drying method were characterized with high swelling properties (>2000%), what is important to ensure the absorption of exudates from wounds. Samples with ZnO particles cross-linked with CaCl2 lost less mass after incubation in aqueous media and were characterized by better dimensional stability than those without crosslinking. The pH of the extracts of the samples containing ZnO particles was more neutral (pH 7.0-7.6) than that of the control gellan gum samples (pH of 5.5-6.1). The zinc release from cross-linked samples was twice as high for those containing nanometric particles than for micrometric particles (1.94 ± 0.04 mg/l and 0.93 ± 0.02, respectively). Relatively large amounts of released zinc species in the case of samples containing ZnO nanoparticles are promising in the context of the antibacterial properties and treatment of infected wounds. A lower amount of zinc released from samples with ZnO microparticles could be sufficient to prevent the development of the infection. Furthermore, both materials show satisfactory cytocompatibility with L929 fibroblasts, as shown by Alamar blue and live/dead viability tests, making them prospective candidates for wound healing
Źródło:
Engineering of Biomaterials; 2023, 26, 168; 2--8
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Own experience from the use of a substitute of an allogeneic acellular dermal matrix revitalized with in vitro cultured skin cells in clinical practice
Autorzy:
Łabuś, Wojciech
Kawecki, Marek
Glik, Justyna
Maj, Mariusz
Kitala, Diana
Misiuga, Marcelina
Klama-Baryła, Agnieszka
Kraut, Małgorzata
Nowak, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/1394264.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
acellular dermal matrix ADM
burn
fibroblasts
keratinocytes
tissue engineering
Opis:
As a result of the removal of cells from human allogeneic dermis, a collagen scaffold is obtained, which can be populated de novo with autologous/allogeneic skin cells and transplanted onto the area of skin loss. The optimal method for production of acellular dermal matrices (ADM) has been selected. Three female patients (a mean age of 54 years) were subjected to the transplantation of either autologous or allogeneic keratinocytes and fibroblasts into the holes of acellular dermal matrix (ADM) mesh graft. The method for burn wound treatment based on the use of a viable dermal-epidermal skin substitute (based on ADM and in vitro cultured fibroblasts and keratinocytes) may be the optimal method of burn treatment.
Źródło:
Polish Journal of Surgery; 2015, 87, 10; 513-521
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
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