Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "fatty liver" wg kryterium: Temat

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-15 z 15
    Tytuł:
    A prospective, interventional clinical study to evaluate the safety and efficacy of Liv.52 DS in the management of non-alcoholic fatty liver disease
    Autorzy:
    Siregar, Gontar
    Paramesh, Rangesh
    Kumawat, Rajesh
    D, Palaniyamma
    HA, Srikrishna
    Powiązania:
    https://bibliotekanauki.pl/articles/2038171.pdf
    Data publikacji:
    2021-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    ALT/AST
    fatty liver
    fibrosis
    non-alcoholic fatty liver disease
    Opis:
    Introduction. Non-alcoholic fatty liver disease (NAFLD) is excessive fat build-up in the liver due to causes other than alcohol use. Aim. To evaluate the clinical efficacy and safety of Liv.52 DS tablets in the management of NAFLD. Material and methods. Prospective, interventional clinical study conducted on 60 patients of both sex, aged between 18-65 years, confirmed with NAFLD from clinical examination, laboratory test, ultrasound findings and those willing to give informed consent. All patients received Liv.52 DS at a dose of 2 tablets twice daily for 2 months. All patients were evaluated at baseline, end of 1st month, and end of 2nd month for liver function tests, hepatomegaly by ultrasound, NAFLD Fibrosis Score, lipid profile, hematology and biochemical investigations. Results. Study data was analyzed with GraphPad Prism Software Version 6.07. Data of those patients who completed the study was considered for analysis. Significant improvement in hepatomegaly, liver enzymes was observed. NAFLD fibrosis score revealed no progression of liver fibrosis due to NAFLD during the study period. No abnormal lab values were recorded and there were no adverse events reported during the study. Conclusion. Study concludes that Liv.52 DS is safe and beneficial in individuals suffering from NAFLD.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 2; 129-136
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fatty liver disease in dairy cattle – risk factors, symptoms and prevention
    Autorzy:
    Bombik, E.
    Sokol, J.
    Pietrzkiewicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2119575.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Zootechniczne
    Tematy:
    dairy cattle
    metabolic disease
    fatty liver
    Opis:
    Fat cow syndrome (fatty liver disease) is a common metabolic problem in dairy cow production during the transition period, from the dry period to lactation. This syndrome occurs when due to liver uptake of non-esterified fatty acids (NEFAs), they are stored in excess as triacylglycerols (TAGs) in the liver. Currently, diagnosis of this disorder must be confirmed by a liver biopsy to determine the fat content of liver cells, as well as blood tests for increased levels of liver enzymes (GGT, SDH, AST, and bilirubin). Fat cow syndrome is associated with the occurrence of clinical diseases, decreased immunity, and problems with reproduction. It is a major problem in the herd health due to the high cost of veterinary services, a longer calving interval, and reduced longevity of cows, causing enormous economic losses. The best means of prevention is good nutrition and routine blood tests in the herd.
    Źródło:
    Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego; 2020, 16, 4; 51-58
    1733-7305
    Pojawia się w:
    Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of probiotic supplementation as alternative therapy for NAFLD: a literature review
    Autorzy:
    Adnan, Muhammad Luthfi
    Powiązania:
    https://bibliotekanauki.pl/articles/1891281.pdf
    Data publikacji:
    2021-12-02
    Wydawca:
    Gdański Uniwersytet Medyczny
    Tematy:
    Non-alcoholic fatty liver disease
    NAFLD
    probiotic
    therapy
    Opis:
    Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, influenced by various risk factors associated with metabolic disorders. Currently there is no specific effective treatment for NAFLD. Probiotics have been extensively researched for their health benefit Probiotic Supplementation for NAFLD. Methods: A simple literature review was performed based on searches via PubMed, ScienceDirect and Google Scholar, using the keywords "probiotic," "microbiota," "non-alcoholic fatty liver disease," "metabolic disorder," and "therapy." Results: Research on the use of probiotics for NAFLD demonstrated improvement in liver function and histology. However, the literature is inconsistent regarding the probiotics’ influence on the NAFLD risk factors. Probiotics can be an alternative therapy for NAFLD through the ability to modulate the microbiota of the gastrointestinal tract. Conclusion: Probiotics can be an alternative therapy in NAFLD patients, however more extensive studies are needed to ensure the safety of this approach.
    Źródło:
    European Journal of Translational and Clinical Medicine; 2021, 4, 2; 75-85
    2657-3148
    2657-3156
    Pojawia się w:
    European Journal of Translational and Clinical Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Impact of bariatric surgery on non-alcoholic fatty liver disease
    Autorzy:
    Major, Piotr
    Pędziwiatr, Michał
    Rubinkiewicz, Mateusz
    Stanek, Maciej
    Głuszewska, Anna
    Pisarska, Magdalena
    Małczak, Piotr
    Budzyński, Andrzej
    Budzyński, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1393188.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    non-alcoholic fatty liver disease
    bariatric surgery
    morbid obesity
    Opis:
    Introduction; p to 300 million people have the body mass index (BMI) greater than 30 kg/m2. Obesity is the cause of many serious diseases, such as type 2 diabetes, hypertension, and non-alcoholic fatty liver disease (NAFLD). Bariatric surgery is the only effective method of achieving weight loss in patients with morbid obesity. Objectives: The aim of the study was to assess the impact of bariatric surgery on non-alcoholic fatty liver disease in patients operated on due to morbid obesity. Material and Methods: We included 20 patients who were qualified for bariatric procedures based on BMI > 40 kg/ m2 or BMI > 35kg/m2 with the presence of comorbidities. The average body weight in the group was 143.85kg, with an average BMI of 49.16kg/m2. Before the procedure, we evaluated the severity of non-alcoholic fatty liver disease in each patient using the Sheriff-Saadeh ultrasound scale. We also evaluated the levels of liver enzymes. Follow-up evaluation was performed twelve months after surgery. Results: Twelve months after surgery, the average weight was 102.34 kg. The mean %WL was 33.01%, %EWL was 58.8%, and %EBMIL was 61.37%. All patients showed remission of fatty liver disease. Liver damage, evaluated with ultrasound imaging, decreased from an average of 1.85 on the Sheriff-Saadeh scale, before surgery, to 0.15 twelve months after surgery (p < 0.001). As regards liver enzymes, the level of alanine aminotransferase decreased from 64.5 (U/l) to 27.95 (U/l) (p < 0.001), and the level of aspartate aminotransferase decreased from 54.4 (U/l) to 27.2 (U/l). Conclusions: Bariatric procedures not only lead to a significant and lasting weight loss, but they also contribute to the reduction of fatty liver disease and improve liver function.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 2; 1-4
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of oleic acid in different solvent media on BRL 3A cell growth and viability
    Autorzy:
    Liu, Runqi
    Yang, Wei
    Xia, Cheng
    Chen, Yuanyuan
    Gao, Sansi
    Dong, Zhihao
    Huang, Baoyin
    Li, Ruirui
    He, Ping
    Xu, Chuang
    Powiązania:
    https://bibliotekanauki.pl/articles/1038377.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    oleic acid
    non-alcoholic fatty liver disease
    liver lipid deposition
    Opis:
    Oleic acid (OA) is widely used in pathology studies of hepatocellular lipid deposition. Identifying the effects of different solvents on OA-induced liver lipid deposition would be beneficial for studies on hepatocytes. We treated BRL 3A cells with OA dissolved in different solvents. After 12 h incubation, cell viability was assessed using MTT assays. Reactive oxygen species (ROS), triglyceride (TG) and total cholesterol (TC) counts, and the expression level of glucose regulated protein (GRP78), sterol regulatory element binding protein (SREBP-1C) and fatty acid synthase (FAS) were analyzed. Water, PBS and DMSO were disadvantageous to the dissolution of OA and did not cause an OA-induced response in hepatocytes. In the alcohol+OA-treated cells, the severe ER stress, oxidative stress and cellular fat deposition were significantly increased. BSA promoted cell growth and the cells treated with 1.2% BSA+OA showed a lower grade TG and endoplasmic reticulum stress compared with KOH+OA and alcohol+OA treatments. KOH had no significant influence on BRL 3A cells viability. When treated with OA dissolved in KOH, BRL 3A cells showed a typical hepatocyte damage. KOH was considered the suitable choice for an OA solvent for BRL 3A cells in hepatic lipidosis research.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 3; 443-447
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of non-alcoholic fatty liver disease and hypercholesterolemia in patients with gallstone disease undergoing laparoscopic cholecystectomy
    Autorzy:
    Singh, Kaptan
    Dahiya, Divya
    Kaman, Lileswar
    Das, Ashim
    Powiązania:
    https://bibliotekanauki.pl/articles/1391850.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    dyslipidemia
    gallstone disease
    liver biopsy
    non-alcoholic fatty liver disease (NAFLD)
    Opis:
    Background: Gallstone disease (GSD) and nonalcoholic fatty liver disease (NAFLD) are connected with a high prevalence in the general population and they share common risk factors for their occurrence. Limited literature with inconsistent results is available, suggesting a potential association between these lifestyle-induced diseases. Liver biopsy is the gold standard for diagnosing NAFLD. The aim of this study was (1) to identify the prevalence of asymptomatic NAFLD or NASH in liver biopsy; (2) to identify the association of hypercholesterolemia with NAFLD in patients undergoing laparoscopic cholecystectomy (LC). Methods: This is a prospective observational study conducted on patients who underwent LC for symptomatic gallstones in the Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, from 1st July 2013 to 31st December 2014. All included patients had ultrasonography (USG) and the following parameters tested: serum triglycerides (TG), cholesterol, low density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). A wedge liver biopsy was obtained from free edge of the right liver lobe during LC and all biopsy specimens were analyzed by a single pathologist. Results: Among 101 patients included in the study, dyslipidemia was present in 49.50%. There was no association between NAFLD and serum cholesterol, TG or LDL-C (P, 0.428, 0.848, 0.371 respectively). NAFLD was confirmed in liver biopsy in 21.8% of patients but none had fibrosis or cirrhosis on biopsy. No complications were observed following liver biopsy. Conclusions: Liver biopsy during LC gives an opportunity to diagnose the disease at an early and reversible stage. It is feasible, safe and cost effective.
    Źródło:
    Polish Journal of Surgery; 2020, 92, 1; 18-22
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Impaired base excision repair is related to the pathogenesis of non-alcoholic fatty liver disease
    Autorzy:
    Ziółkowska, Sylwia
    Czarny, Piotr
    Szemraj, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1024273.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    DNA repair
    non-alcoholic fatty liver
    base excision repair
    Opis:
    Non-alcoholic fatty disease (NAFLD) is a liver disorder that affects up to 30% of the population, mainly in Western countries. It is estimated that up to 75% of NAFLD patients will develop a more aggressive form of the disease, non-alcoholic steatohepatitis (NASH). NAFLD can lead to fibrosis and liver failure; however, it is difficult to diagnose NAFLD due to its non-specific symptoms. Unfortunately, there is no treatment available for this disease. The risk factors of NAFLD are obesity and insulin resistance (IR). The molecular factors that seem to play an important role in the pathogenesis of NAFLD are oxidative stress as well as impaired DNA damage repair processes; a great body of evidence confirms an association with the base excision repair (BER) pathway. The activity of BER is decreased in patients with NAFLD and in animal models of this disease. In order to better understand the underlying basis of the disease, knowledge should be broadened in the area of DNA repair in NAFLD.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2020, 16; 5-11
    1730-2366
    2083-8484
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ultrasonography as a diagnostic and prognostic approach in cattle and buffaloes with fatty infiltration of the liver
    Autorzy:
    Tharwat, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/30512.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    ultrasonography
    diagnostics
    prognosis
    cattle
    buffalo
    fatty infiltration
    liver
    fatty liver
    hepatic lipidosis
    lipid metabolism
    dairy cow
    Opis:
    The aim of the present study was to determine whether ultrasonographic evaluation of the hepatic parenchyma could be used as a diagnostic and prognostic approach in cows and buffaloes with hepatic lipidosis. For this purpose, cows (n=16) and buffaloes (n=10) with fatty infiltration of the liver were examined by ultrasonography. Treated cows and buffaloes were monitored for hepatic changes ultrasonographically, biochemically and histologically. Clinical findings were non-specific and included anorexia, recumbency, muzzle necrosis, and icteric mucosal membranes. Laboratory data revealed neutrophilia, hyper γ-globulinemia, elevated activities of aspartate aminotransferase, γ-glutamyl transpeptidase, creatine kinase and lactate dehydrogenase, and high concentrations of insulin, total bilirubin, non-esterified fatty acids and β-hydroxyl butyric acid. Laboratory results 7, and 21 days after treatment showed progressive improvement in the chemistry profile. On admission, ultrasonographic examination of the hepatic parenchyma in cows and buffaloes revealed either increased or decreased hepatic echogenicity; histologic examination revealed marked fatty infiltration of the hepatocytes. One week after treatment, the hepatic parenchyma was visualized easily, liver boundaries were clearly imaged, and histologic examination of hepatic specimen showed a moderate degree of fatty infiltration. Three weeks after treatment, the hepatic parenchyma was almost similar to normal, the hepatic and portal blood vessels could be easily imaged, and the histologic picture had greatly improved where the liver resembled the normal organ. Six cows and seven buffaloes made a full recovery while the remaining ten cows and three buffaloes were slaughtered and thoroughly examined postmortem. Ultrasonography showed a good correlation with histologic and laboratory findings.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ultrasound imaging of the liver and bile ducts – expectations of a clinician
    Badanie ultrasonograficzne wątroby i dróg żółciowych – oczekiwania klinicysty
    Autorzy:
    Skoczylas, Krzysztof
    Pawełas, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1053137.pdf
    Data publikacji:
    2015
    Wydawca:
    Medical Communications
    Tematy:
    CEUS
    bile ducts
    elastography
    fatty liver
    ceus
    drogi żółciowe
    elastografia
    stłuszczenie wątroby
    Opis:
    Since diseases of the liver and bile ducts are common, a clinician is faced by the need to implement an appropriate diagnostic process. It is necessary to apply diagnostic methods that enable appropriate assessment of the most common pathologies of the liver, i.e. fibrosis, steatosis and focal lesions, as well as initial assessment of the bile ducts. These goals can be achieved using ultrasound methods based on conventional sonography, contrast-enhanced sonography and elastography. The assessment of fatty liver and bile duct dilatation using ultrasound reaches satisfactory levels of sensitivity and specificity. The usage of contrast agents enables unambiguous differentiation between benign and malignant focal lesions, frequently allowing them to be identified accurately without the assistance of other imaging modalities. Elastography has enabled reliable assessment of liver fibrosis. Its results are comparable to those of the standard method, i.e. liver biopsy.
    W związku z powszechnym występowaniem chorób wątroby i dróg żółciowych klinicysta stoi przed problemem wdrożenia odpowiedniej diagnostyki. Istnieje potrzeba stosowania metod diagnostycznych umożliwiających odpowiednią ocenę najczęstszych patologii wątroby, to jest włóknienia, stłuszczenia miąższu wątroby, różnicowania zmian ogniskowych, czy wstępną ocenę patologii dróg żółciowych. Na osiągnięcie tych celów pozwala zastosowanie metod ultrasonograficznych opartych na klasycznej ultrasonografii, ultrasonografii z wykorzystaniem kontrastów dożylnych i elastografii. Ultrasonograficzna ocena stłuszczenia wątroby i poszerzenia dróg żółciowych osiąga zadowalającą czułość i specyficzność. Zastosowanie kontrastów dożylnych pozwala na jednoznaczne różnicowanie między łagodnymi a złośliwymi zmianami ogniskowymi, często umożliwiając prawidłową ich identyfikację bez konieczności stosowania innych metod badań obrazowych. Zastosowanie metody elastografii umożliwiło wiarygodną ocenę włóknienia wątroby, z wynikami porównywalnymi do standardowej metody, jaką jest biopsja wątroby.
    Źródło:
    Journal of Ultrasonography; 2015, 15, 62; 292-306
    2451-070X
    Pojawia się w:
    Journal of Ultrasonography
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of high fat diet on structure of liver and gallbladder of adult male mice – an experimental study
    Autorzy:
    Hegazy, Abdelmonem Awad
    Qenawy, Noura M.
    Aziz, Nada M. Abdel
    El-Bestawy, Emtethal M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2040247.pdf
    Data publikacji:
    2021-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    COX-2
    fatty liver
    gallbladder epithelium
    immunoexpression
    Oil Red O staining
    Opis:
    Introduction. High fat diet (HFD) intake induces obesity and adversely affects different body organs including liver and gallbladder. Aim. It was to clarify the effects of HFD on the liver and gallbladder structure using light microscopic (LM) examination. Material and methods. 16 healthy adult male mice were equally divided into 2 groups. Control group mice were fed normal diet. HFD group was fed using HFD. At the end of the 8-week experiment, mice were anesthetized. Liver and gallbladder were removed and prepared to histological processing. Sections were stained with hematoxylin and eosin (H&E) and immunostaining for cyclooxygenase-2 (COX-2) cellular localization. Oil Red O (ORO)-stained frozen liver sections were prepared. Results. H&E-stained sections of HFD group revealed rounded swollen hepatic cells with pale cytoplasm suggesting cellular ballooning. Dilated congested sinusoids and portal vein, cellular degeneration and collection of inflammatory cells were observed between hepatic cells and in portal region. Gallbladder sections showed epithelial stratification and cellular vacuolation. Strong immunoexpression of COX-2 was observed in Kupffer and hepatic cells of the liver and gallbladder mucosal epithelial cells. Conclusion. HFD is suggested to alter the normal histological features of liver and gallbladder represented by fatty liver and gallbladder epithelial hyperplasia and inflammatory reaction.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 4; 291-298
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of genetic modification of the PNPLA3 gene in predicting metabolically unhealthy obesity and metabolic associated fatty liver disease in children
    Autorzy:
    Abaturov, Aleksandr
    Nikulina, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/2207159.pdf
    Data publikacji:
    2023-03-25
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    children
    metabolic associated fatty liver disease
    obesity
    patatin‐like phospholipase domain‐containing protein 3
    single nucleotide variants
    Opis:
    Introduction and aim. Single nucleotide variants (SNV) of the patatin‐like phospholipase domain‐containing protein 3 (PNP-LA3) gene play an important role in hepatic lipid remodeling and lipogenesis de novo, which is associated with the development of metabolically unhealthy obesity (MUO) and metabolic associated fatty liver disease (MAFLD). The aim of the study was to define the contribution of SNV PNPLA3 gene to the development of MUO, complicated by MAFLD in children. Material and methods. 200 obese children aged 6-18 years were examined. The main group (n=118) was represented by children with MUO. The control group (n=82) consolidated of children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat) was performed in 31 children of the main and 21 children of the control group. Results. Among obese children, 14 variants of SNV PNPLA3 (rs139051, rs34179073, rs2294918, rs139047, rs779127153, rs2076212, rs738409, rs738408, rs4823173, rs2072906, rs2076213, rs141106484, rs138736228) were identified, including SNV PNPLA3 g.44322818, not described in the dbSNP core database. The role of the following SNV PNPLA3 genotypes in the development of MUO complicated by MAFLD was revealed: rs738409 C/G (Relative risk (RR)=1.71); rs738408 C/T (RR=1.71); rs4823173 G/A (RR=1.57); rs2072906 A/G (RR=1.57) with Sensitivity (Se)=0.63 and Specificity (Sp)=0.72. Conclusion. The contribution to the development of MUO complicated by MAFLD in children is made by the linked association of genotypes: rs738409 C/G, rs738408 C/T, rs4823173 G/A and rs2072906 A/G out of 14 PNPLA3 SNVs diagnosed by us.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2023, 1; 5-13
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stłuszczenie wątroby jako czynnik ryzyka chorób sercowo-naczyniowych: analiza retrospektywna danych pacjentów Kliniki Geriatrii Uniwersyteckiego Szpitala Klinicznego we Wrocławiu
    Fatty liver as a risk factor for cardiovascular diseases: retrospective analysis of data from patients of the Geriatrics Clinic of University Clinical Hospital in Wrocław
    Autorzy:
    Szymala-Pędzik, Małgorzata
    Piersiak, Marcin
    Pachana, Maciej
    Tomczak, Wojciech
    Sobieszczańska, Małgorzata I.
    Janocha, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/39795055.pdf
    Data publikacji:
    2024-07-25
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    otyłość
    BMI
    ryzyko sercowo-naczyniowe
    hipercholesterolemia
    stłuszczenie wątroby
    przerost mięśnia lewej komory
    obesity
    cardiovascular risk
    hypercholesterolemia
    fatty liver disease
    left ventricular hypertrophy
    Opis:
    Wstęp Niealkoholowa stłuszczeniowa choroba wątroby (non-alcoholic fatty liver disease – NAFLD) to obecnie najczęstsze schorzenie wątroby dotyczące ok. 25% populacji światowej. Za przyczyny jej rozwoju uznaje się nieprawidłową dietę, niską aktywność fizyczną, nadwagę i otyłość, starszy wiek, cukrzycę oraz zaburzenia lipidowe. Choroba jest uznawana przez część badaczy za wątrobową manifestację zespołu metabolicznego. Zaobserwowano, że u pacjentów z NAFLD zwiększone jest ryzyko zdarzeń sercowo-naczyniowych oraz liczba zgonów z powodu zawału mięśnia sercowego w porównaniu z populacją ogólną. Materiał i metody Przeprowadzono retrospektywną analizę danych 237 pacjentów z rozpoznanym stłuszczeniem wątroby leczonych w Klinice Geriatrii Uniwersyteckiego Szpitala Klinicznego we Wrocławiu w latach 2019–2022 pod kątem współistnienia nadwagi, otyłości i chorób współistniejących. Przeanalizowano wyniki badań laboratoryjnych oraz stopień przerostu mięśnia lewej komory serca. Do oceny przerostu mięśnia użyto ocenianych w echokardiografii parametrów: grubość przegrody międzykomorowej w rozkurczu (interventricular septal thickness in diastole – IVSd), grubość późnorozkurczowa tylnej ściany lewej komory (left ventricular posterior wall thickness in diastole – LVPWd) i IVSd + LVPWd/2. Wyniki Przeanalizowano dane 237 pacjentów: 79 mężczyzn (wiek: 77,2±7,1 roku) i 158 kobiet (wiek: 78,4±7,7 roku). Wartości wskaźnika masy ciała (body mass index – BMI) dla mężczyzn i kobiet wynosiły, odpowiednio, 30,5±5,0 kg/m² oraz 31,9±5,6 kg/m². Wykazano istnienie dodatniej korelacji między wielkością BMI a stopniem przerostu mięśnia lewej komory dla parametrów IVSd (ρ = 0,36, p < 0,001), LVPWd (ρ = 0,36, p < 0,001) i IVSd + LVPWd/2 (ρ = 0,38, p < 0,001). Wnioski W badaniu wykazano dodatnią korelację o umiarkowanej sile między wielkością BMI a stopniem przerostu mięśnia lewej komory u chorych z rozpoznanym stłuszczeniem wątroby. Wyniki te wskazują na konieczność aktywnego poszukiwania czynników ryzyka chorób sercowo-naczyniowych, w tym oceny parametrów echokardiograficznych u pacjentów z NAFLD.
    Background Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disorder affecting about 25% of the global population. The causes of its development include poor diet, low physical activity, overweight, obesity, older age, diabetes, and lipid disorders. Non-alcoholic fatty liver disease is identified by some researchers as a hepatic manifestation of metabolic syndrome. It has been observed that patients with NAFLD have an increased risk of cardiovascular events, as well as a higher number of deaths from myocardial infarction compared to the general population. Material and Methods A retrospective analysis was conducted on the data of 237 patients diagnosed with hepatic steatosis, treated in the Department of Geriatrics at the University Clinical Hospital in Wrocław from 2019 to 2022, focusing on coexisting overweight, obesity, and concomitant diseases. Laboratory results and the degree of left ventricular muscle hypertrophy were analyzed. Parameters assessed by echocardiography, including interventricular septal thickness in diastole (IVSd), left ventricular posterior wall thickness in diastole (LVPWd), and IVSd + LVPWd/2, were used to evaluate left ventricular hypertrophy. Results Data from 237 patients were analyzed: 79 men (age: 77.2±7.1 years) and 158 women (age: 78.4±7.7 years). Body mass index (BMI) values for men and women were 30.5±5.0 kg/m² and 31.9±5.6 kg/m², respectively. There was a positive correlation between BMI and the degree of left ventricular hypertrophy for the parameters IVSd (ρ = 0.36, p < 0.001), LVPWd (ρ = 0.36, p < 0.001), and IVSd + LVPWd/2 (ρ = 0.38, p < 0.001). Conclusions The study demonstrated a moderate positive correlation between BMI and the degree of left ventricular hypertrophy in patients diagnosed with hepatic steatosis. These findings indicate the necessity of actively searching for cardiovascular risk factors, including the evaluation of echocardiographic parameters in patients with NAFLD.
    Źródło:
    Medycyna Pracy. Workers’ Health and Safety; 2024, 75, 3; 223-231
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy. Workers’ Health and Safety
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hepatokines and non-alcoholic fatty liver disease
    Autorzy:
    Lebensztejn, Dariusz
    Flisiak-Jackiewicz, Marta
    Białokoz-Kalinowska, Irena
    Bobrus-Chociej, Anna
    Kowalska, Irina
    Powiązania:
    https://bibliotekanauki.pl/articles/1038763.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    non-alcoholic fatty liver disease
    fetuin-A
    fibroblast growth factor-21
    selenoprotein P
    sex hormone-binding globulin
    angiopoietin-related growth factor
    leukocyte derived chemotaxin 2
    Opis:
    Nowadays non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver pathology both in adults and children. NAFLD manifestation ranges from a simple liver steatosis to steatohepatitis (nonalcoholic steatohepatitis - NASH), which may progress to advanced fibrosis, cirrhosis and end-stage liver disease. Due to the coexistence of visceral obesity, insulin resistance and dyslipidemia, NAFLD is considered to be the hepatic manifestation of metabolic syndrome. In recent years, in the pathogenesis of metabolic syndrome, type 2 diabetes mellitus, cardiovascular disease and also NAFLD, more and more attention has been paid to the so-called organokines, proteins with both paracrine or/and endocrine activities. These include most known adipokines (mainly produced by adipose tissue), myokines (mainly produced by skeletal muscles) and hepatokines exclusively or predominantly produced by the liver. It was shown that the liver may affect the lipids and glucose metabolism by hepatokines released into the blood and NAFLD seems to be associated with altered hepatokines production. Fetuin-A, fibroblast growth factor-21 (FGF-21), selenoprotein P, sex hormone-binding globulin (SHBG), angiopoietin-related growth factor (also known as angiopoietin-related protein 6) and leukocyte derived chemotaxin 2 (LECT2) are considered as the most important hepatokines. In this review, we provide an overview of the main hepatokines and we summarize the association of liver-derived proteins with the development and progression of NAFLD.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 459-467
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cardiometabolic risk prediction in patients with non-alcoholic fatty liver disease combined with subclinical hypothyroidism
    Przewidywanie ryzyka kardiometabolicznego u pacjentów z niealkoholową stłuszczeniową chorobą wątroby w połączeniu z subkliniczną niedoczynnością tarczycy
    Autorzy:
    Kolesnikova, Olena
    Vуsotska, Olena
    Potapenko, Anna
    Radchenko, Anastasia
    Trunova, Anna I.
    Virstyuk, Nataliya
    Vasylevska-Skupa, Liudmyla
    Kalizhanova, Aliya
    Mukanova, Nazerka
    Powiązania:
    https://bibliotekanauki.pl/articles/27315426.pdf
    Data publikacji:
    2023
    Wydawca:
    Politechnika Lubelska. Wydawnictwo Politechniki Lubelskiej
    Tematy:
    cardiometabolic risk
    non-alcoholic fatty liver disease
    subclinical hypothyroidism
    prediction
    binary regression logistic analysis
    validation of prognostic models
    ryzyko kardiometaboliczne
    niealkoholowe stłuszczenie wątroby
    subkliniczna niedoczynność tarczycy
    rokowanie
    binarna analiza regresji logistycznej
    walidacja modeli prognostycznych
    Opis:
    One of the most common diseases of our time is non-alcoholic fatty liver disease (NAFLD). Recently published research results indicate that patients with NAFLD along with traditional risk factors for cardiovascular diseases (CVD) have "new"risk factors such as endothelial dysfunction (ED), carotid intima-media thickness (CIMT), an increase in the CRP level, as well as risk factors combined into the Framingham scale. It is also knownthat combination of NAFLD with subclinical hypothyroidism (SH) forms an abnormal metabolic phenotype, which is associated with cardiometabolicrisk factors. The study of cardiometabolic predictors and vascular markers in patients with NAFLD in combination with SH willprovide an opportunityto improve the strategy of cardiovascular events prevention in such comorbid patients.
    Niealkoholowe stłuszczenie wątroby (NAFLD) jest jedną z najczęstszych chorób naszych czasów. Ostatnio opublikowane wyniki badań sugerują, że pacjenci z NAFLD, wraz z tradycyjnymi czynnikami ryzyka chorób sercowo-naczyniowych (CVD), mają "nowe" czynniki ryzyka, takie jak dysfunkcja śródbłonka (ED), grubość błony wewnętrznej i środkowej tętnicy szyjnej (CIMT), podwyższony poziom CRP i czynniki ryzyka połączone w skali Framingham. Wiadomo również, że połączenie NAFLD z subkliniczną niedoczynnością tarczycy (SH) tworzy nieprawidłowy fenotyp metaboliczny związany z czynnikami ryzyka kardiometabolicznego. Badanie predyktorów kardiometabolicznych i markerów naczyniowych u pacjentów z NAFLDw połączeniu z SH pozwoli na ulepszenie strategii zapobiegania zdarzeniom sercowo-naczyniowym u takich współistniejących pacjentów.
    Źródło:
    Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska; 2023, 13, 2; 64--68
    2083-0157
    2391-6761
    Pojawia się w:
    Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Liver content of fatty acids and reproductive indices of carp in relation to level of dietary vitamin A
    Zawartość kwasów tłuszczowych w wątrobie oraz wskaźniki rozrodcze karpia w stosunku do poziomu w diecie witaminy A
    Autorzy:
    Maletich, M.B.
    Rivis, J.F.
    Powiązania:
    https://bibliotekanauki.pl/articles/44665.pdf
    Data publikacji:
    2015
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    fish breeding
    common carp
    animal feeding
    fish feed
    feed supplement
    vitamin A
    fatty acid
    liver
    Źródło:
    Acta Scientiarum Polonorum. Zootechnica; 2015, 14, 3
    1644-0714
    Pojawia się w:
    Acta Scientiarum Polonorum. Zootechnica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-15 z 15

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies