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Tytuł:
Anticancer properties of Viburnum
Autorzy:
Stępień, Agnieszka
Aebisher, David
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454949.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
antitumor activity
Viburnum species
cytotoxic activity
Opis:
Aim. The aim of this paper is to provide an overview of the anticancer properties of different species of Viburnum. Materials and methods. Forty nine papers that discuss the medicinal history and current research of Viburnum species as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research conducted in vitro indicate that the compounds present in the extracts of Viburnum significantly affect the development of cancer cells such as leukemia, cervical cancer, breast, colon, lung, skin and stomach. This indicates that they may be used as a therapeutic agent to support oncological therapies.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 47-52
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxic and anticancer activity of Moringa oleifera
Autorzy:
Szlachetka, Kinga
Kut, Paulina
Stepien, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2038320.pdf
Data publikacji:
2020-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
anticancer activity
cytotoxic activity
Moringa oleifera
Opis:
Introduction. Given its very strong antioxidant properties, Moringa oleifera is particularly noteworthy among medicinal plants. The high contents antioxidants in the M. oleifera determining her antioxidant activities deciding for very important anticancer properties. Aim. The aim of the paper is to provide an overview of the cytotoxic and anticancer activity of Moringa oleifera. Material and methods. This review was performed based systematic analysis of literature. Analysis of the literature. The results of scientific research conducted in vitro indicate that extracts from Moringa oleifera significantly affect the development of human cancer cells such as myeloma, leukemia, cervix, breast, colon, lung, liver, neuroblastoma, pancreas, colorectal, epidermoid, oral, ovarian, muscular, prostate, skin. Conclusion. This indicates Moringa oleifera as that they may be used as a therapeutic agent to support oncological therapies.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 3; 214-220
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxic and anti-cancer activity of the Cistus species of herbal plants
Autorzy:
Stępień, Agnieszka Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454781.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
anti-tumor activity
Cistus species
cytotoxic activity
phytotherapeutics
Opis:
Aim. The aim of this paper is to provide an overview of the cytotoxic and anti-cancer properties of the major species of the genus Cistus. Materials and methods. Thirty four papers that discuss the medicinal history and current research of Cistus species as phytotherapeutics were used for this discussion. Literature analysis.The growing popularity of the Cistus species of herbs is mainly due to its anti-inflammatory, antimicrobial, antifungal and antioxidant properties. The results of in vitro studies indicate that the presence of pear extract significantly affects leukemia, leukemia, breast, colon, ovarian, pancreatic, and melanoma carcinomas. The significant growth inhibition of these cells, underlines its valuable anti-tumor properties and allows for the possibility of use as a therapeutic aid.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 165-168
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings.
Autorzy:
Bontemps-Gracz, Maria
Kupiec, Agnieszka
Antonini, Ippolito
Borowski, Edward
Powiązania:
https://bibliotekanauki.pl/articles/1043812.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
acridine cytostatics
cytotoxic activity
multidrug resistance
antitumor compounds
Opis:
Two recently synthesized groups of acridine cytostatics containing fused heterocyclic ring(s): pyrazoloacridines (PAC) and pyrazolopyrimidoacridines (PPAC) were tested in regard to their in vitro cytotoxic activity towards a panel of sensitive and resistant human tumor cell lines. The obtained results corroborate our earlier hypothesis on the essential role of heterocyclic ring fused to the acridine moiety in the ability of acridine cytostatics to overcome multidrug resistance of tumor cells. The presence, location and kind of substituents considerably influenced both the cytotoxic activity of the derivatives and their ability to overcome multidrug resistance. The same factors also affected the cytostatics ability to differentiate between tumor cell lines with various types of drug exporting pumps.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 87-92
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antiviral and cytotoxic activities of anthraquinones isolated from Cassia roxburghii Linn. leaves
Aktywność antywirusowa i cytotoksyczna antrachinonów wyizolowanych z liści Cassia roxburghii Linn.
Autorzy:
Mohammed, M.M.D.
El-Souda, S.S.
El-Hallouty, S.M.
Kobayashi, N.
Powiązania:
https://bibliotekanauki.pl/articles/72443.pdf
Data publikacji:
2013
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
antiviral activity
cytotoxic activity
anthraquinone
isolation
Cassia roxburghii
leaf
Opis:
The cytotoxic activity of petroleum ether extract of the leaves of Cassia roxburghii Linn. against HCT-116 and MCF-7 cell lines resulted with IC50=34.9 and 38.04 μg/ml, respectively, while against HepG-2 showed no activity. A bioassay guided-fractionation approach was conducted to isolate and identify the active cytotoxic principles. Further chromatographic separation and purification of the petroleum ether extract resulted in the isolation of two anthraquinones identified as aloe-emodin acetate and aloe-emodin, along with stigmasterol, β-sitosterol and palmitic acid. The structure elucidation of isolated compounds was performend using 1D, 2D-NMR and HR-MS. Furthermore, the cytotoxicity of aloe-emodin acetate and aloe-emodin were evaluated and resulted with IC50=153.30 and 70.02 μg/ml against HCT-116 and with 93.20 and 53.20 μg/ml against MCF-7, respectively, while against HepG-2 showed no activity. Moreover, the antiviral activity of the two isolated anthraquinones was tested against influenza virus-A, and resulted with IC50=10.23 as well as 2.00 and with CC50=1.32 and 0.47 μg/ml, respectively.
Aktywność cytotoksyczna wyciągu benzynowego z liści Cassia roxburghii Linn. przeciwko liniom komórkowym HCT-116 i MCF-7 wynosiła odpowiednio IC50=34.9 i 38,04 μg/ ml, natomiast nie wykazano aktywności przeciwko HepG-2. Przeprowadzono biologiczne frakcjonowanie w celu wyizolowania i identyfikacji aktywnych związków o działaniu cytotoksycznym. Późniejsza separacja chromatograficzna i oczyszczenie wyciągu benzynowego zaowocowało wyizolowaniem dwóch antrachinonów oznaczonych jako octan aloe-emodyny i aloe-emodyna, a także stigmasterolu, β-sitosterolu i kwasu palmitynowego. Określenie struktury wyizolowanych składników przeprowadzono przy użyciu 1D, 2D-NMR i HR-MS. Określono także cytotoksyczność octanu aloe-emodyny i aloe-emodyny, której wartość wyniosła odpowiednio IC50=153,30 i 70,02 μg/ml przeciwko HCT-116 oraz odpowiednio 93,20 i 53,20 μg/ml przeciwko MCF-7. Nie wykazano aktywności przeciwko HepG-2. Testowano też aktywność przeciwwirusową dwóch wyizolowanych antrachinonów przeciwko wirusowi grypy typu A. Wyniosła ona odpowiednio IC50=10,23 oraz 2,00 przy CC50=1,32 i 0,47 μg/ml.
Źródło:
Herba Polonica; 2013, 59, 4
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Organometallic iron complexes as potential cancer therapeutics
Autorzy:
Mojžišová, Gabriela
Mojžiš, Ján
Vašková, Janka
Powiązania:
https://bibliotekanauki.pl/articles/1039190.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
organometallic iron complexes
cytotoxic and antiproliferative effects
anticancer agents
Opis:
Metal-containing drugs have long been used for medicinal purposes in more or less empirical way. The potential of these anticancer agents has only been fully realised and explored since the discovery of the biological activity of cisplatin. Cisplatin and carboplatin have been two of the most successful anti-cancer agents ever developed, and are currently used to treat ovarian, lung and testicular cancers. They share certain side effects, so their clinical use is severely limited by dose-limiting toxicity. Inherent or acquired resistance is a second problem often associated with platinum-based drugs, with further limits of their clinical use. These problems have prompted chemists to employ different strategies in development of the new metal-based anticancer agents with different mechanisms of action. There are various metal complexes still under development and investigation for the future cancer treatment use. In the search for novel bio-organometallic molecules, iron containing anti-tumoral agents are enjoying an increasing interest and appear very promising as the potential drug candidates. Iron, as an essential cofactor in a number of enzymes and physiological processes, may be less toxic than non essential metals, such as platinum. Up to now, some of iron complexes have been tested as cytotoxic agents and found to be endowed with an antitumor activity in several in vitro tests (on cultured cancer cell lines) and few in vivo experiments (e. g. on Ehrlich's ascites carcinoma). Although the precise molecular mechanism is yet to be defined, a number of observations suggest that the reactive oxygen species can play important role in iron-induced cytotoxicty. This review covers some relevant examples of research on the novel iron complexes.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 651-654
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE INFLUENCE OF POLYETHER SUBSTITUENTS ON BIOLOGICAL ACTIVITY OF CURCUMIN DERIVATIVES
Autorzy:
Gruber, Beata M.
Tomasz, Deptuła
Adam, Krówczyński
Irena, Bubko
Powiązania:
https://bibliotekanauki.pl/articles/895397.pdf
Data publikacji:
2020-02-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Chemical synthesis
cytotoxic activity
curcumin derivatives
antitumor drugs
Opis:
Curcumin is reported as an anti proliferative and chemopreventive compound. However, it shows poor water solubility, low bioavailability, and rapid metabolism.. To address these problems, curcumin derivatives substituted with polyether chain were synthesised to improve the hydrophilicity of curcumin and thus its bioavailability. The biological activity of modified curcumin molecules were studied with human normal B-lymphocytes GM 14667 and human leukemia cells HL60 and covered: the denotation of IC50 values for each new compound with use of MTT test and the studies on apoptosis induction observed as morphological changes and the expression of apoptotic proteins, BAX, BCL-2 and survivin with use of Western Blot analysis. All effects were referenced to native curcumin. The derivatives with modified polyether chains number and the position of methoxy- groups were selected for further studies. As was shown, the solubility of the compound does not directly correlate with its cytotoxicity. The maintenance of the methoxy group in the meta position as well as the introduction of hydrophilic polyether chains but not the number of polyether chains may affect the cytotoxic activity of curcumin derivatives against cancer cells. Modifications of the curcumin molecule structure can determine its impact on the profile of pro or anti apoptotic proteins.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 99-111
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ASSESSMENTS OF ANTIOXIDANT CONTENT AND THE ANTI-CARCINOGENIC EFFECT OF EXTRACTS OF SOLANUM ROSTRATUM DUNAL IN HUMAN CANCER CELLS
Autorzy:
Valadez Vega, María del Carmen
Izquierdo Vega, Jeannett Alejandra
Villagómez Ibarra, Jose Roberto
Sánchez Gutiérrez, Manuel
Madrigal Santillán, Eduardo Osiris
Morales Gonzalez, Jose Antonio
Bautista Ávila, Mirandeli
García Velasco, Laura
Powiązania:
https://bibliotekanauki.pl/articles/895384.pdf
Data publikacji:
2019-06-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
antioxidant
cytotoxic
Solanum rostratum
SiHa cell line
MDA cell line
Opis:
In Mexico, Solanum rostratum has been employed for the treatment of several diseases, including uterine cancer. The aim of this study was to evaluate the antioxidant and anti-carcinogenic activity of extracts of Solanum rostratum Dunal on MDA and SiHa cell lines. The methanolic, ethyl acetate, and hexane extracts of the aerial parts of Solanum rostratum were tested for phenols concentration, antioxidant activity, and anti-carcinogenic effect. The leaves extracts showed the highest content of phenols; however the flower-fruits extracts showed higher scavenging activity. On the other hand, ethyl acetate extracts exhibited the highest anti-carcinogenic effect, while methanolic extracts showed the least effect. The results of this work indicated that Solanum rostratum is a promising source of antioxidants, and the extracts exert a dose-dependent anti-carcinogenic effect on both cell lines.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 493-502
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Certain protein transducing agents convert translocated proteins into cell killers
Autorzy:
Tcherniuk, Siergiej
Fiser, Anne-Laure
Derouazi, Madiha
Toussaint, Bertrand
Wang, Yan
Wojtal, Izabela
Kondo, Eisaku
Szolajska, Ewa
Chroboczek, Jadwiga
Powiązania:
https://bibliotekanauki.pl/articles/1039725.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cytotoxic protein
cell transduction
protein delivery
cell translocation
transducing peptides
Opis:
The majority of proteins are unable to translocate into the cell interior. Hence for peptide- and protein-based therapeutics a direct intracytoplasmic delivery with the aid of transducing agents is an attractive approach. We wanted to deliver to the cell interior a putatively cytotoxic protein VPg. Protein transduction was achieved in vitro with three different commercial products. However, in our hands, delivery of various control proteins without known deleterious effects, as well as of protein VPg, always induced cell death. Finally, we used a novel transducing peptide Wr-T, which was not toxic to cultured cells, even in a quite large range of concentrations. Most importantly, control protein delivered to cells in culture did not display any toxicity while VPg protein exerted a strong cytotoxic effect. These data show that results obtained with cell-penetrating agents should be interpreted with caution.
Źródło:
Acta Biochimica Polonica; 2012, 59, 3; 433-439
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxic flavonoids from Diplotaxis harra (Forsk.) Boiss. growing in Sinai
Cytotoksyczność flawonoidów pochodzących z roslin Diplotaxis harra (Forsk.) Boiss. osnącej na Półwyspie Synaj
Autorzy:
Mohammed, M.M.D.
El-Sharkawy, E.R.
Matloub, A.A.
Powiązania:
https://bibliotekanauki.pl/articles/71877.pdf
Data publikacji:
2011
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
cytotoxic flavonoids
flavonoids
cytotoxicity
Diplotaxis harra
Sinai
medicinal plant
Opis:
As a part of our ongoing collaborative effort to discover the anticancer activity of the phenolics isolated from terrestrial plant sources, the EtOH extract of the aerial parts of the Egyptian medicinal plant Diplotaxis harra (Forsk.) Boiss. was in vitro investigated for its cytotoxicity against HCT116, HepG2 and MCF-7 cell lines, and resulted with IC50=4.65, 12.60 and 17.90 μg/ml, respectively. Doxorubicin (+ve control) showed in vitro cytotoxic activity with IC50=3.64, 4.57 and 2.97 μg/ml, respectively. The phenolic-rich fraction of the EtOH extract was subjected to further fractionation, which led to the isolation of five flavonoids identified as quercetin, quercetin 3-O-β-glucoside, isorhamnetin 7-O-β-glucoside, apigenin 3-O-β-rhamnoside and kaempferol 3-O-β-glucoside, according to its’ spectral data and comparison with the literature. Furthermore, the isolated flavonoids showed in vitro cytotoxicity against HCT116 cell line with IC50=20.1, 24.3, 22.8, 23.4 and 41.9 μg/ml as determined by MTT method.
W ramach badań nad poszukiwaniem nowych związków fenolowych o aktywności przeciwnowotworowej pochodzących z roślin lądowych badaniom w kierunku cytotoksyczności w warunkach in vitro w poddano wyciąg alkoholowy z nadziemnych części egipskiej rośliny leczniczej Diplotaxis harra (Forsk.) Boiss. W wyniku przeprowadzonych badań cytotoksyczności z wykorzystaniem linii komórkowych HCT116, HepG2 oraz MCF-7 otrzymano odpowiednio następujące wartości: IC50=4,65, 12,60 oraz 17,90 μg/ml. Doksorubicyna (kontrola pozytywna) w warunkach in vitro wykazała w stosunku do badanych linii komórkowych następującą aktywność cytotoksyczną: odpowiednio IC50=6,64, 4,57 oraz 2,97 μg/ml. Dalsze rozdzielanie frakcji wyciągu etanolowego, bogatej w związki fenolowe, doprowadziło do wyizolowania pięciu flawonoidów: kwercetyny, 3-O-β-glukozydu kwercetyny, 7-O-β-glukozydu izoramnetyny, 3-O-β-ramnozydu apigeniny oraz 3-O-β-glukozydu kemferolu (zidentyfikowanych według danych spektralnych oraz na podstawie porównania z danymi pochodzącymi z literatury przedmiotu). Ponadto wyizolowane flawonoidy wykazywały in vitro cytotoksyczność określoną przy użyciu metody MTT w stosunku do linii HCT116 na poziomie IC50 =20,1, 24,3, 22,8, 23,4 oraz 41,9 μg/ml.
Źródło:
Herba Polonica; 2011, 57, 3
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Seasonal variation in biopharmaceutical activity and fatty acid content of endemic Fucus virsoides algae from Adriatic Sea
Autorzy:
Grozdanić, Nađa
Zdunić, Gordana
Šavikin, Katarina
Đuričić, Ivana
Kosanić, Marijana
Mačić, Vesna
Matić, Ivana Z.
Stanojković, Tatjana P.
Powiązania:
https://bibliotekanauki.pl/articles/895444.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
fatty acid
antimicrobial activity
cytotoxic activity
anticancer
α-glucosidase
Fucus virsoides
Opis:
Macroalgae from Fucus genus are a valuable source of bioactive components as they are abundant in complex polysaccharides, fatty acids and polyphenols. In this work, the biological activity and chemical composition of extracts and fractions obtained from endemic Fucus virsoides J. Agardh species collected in the summer and in the fall were investigated. From dichloromethane:methanol (1:1) extract three fractions were made: petroleum-ether, ethyl-acetate and n-butanol. The aim of the study was to examine the influence of the seasonal variations on algal composition and activity. The significant seasonal variation in content and biological activity of Fucus virsoides samples was found. Fall extract and fractions exerted higher cytotoxic effects on cancer cell lines in comparison with summer extract and fractions. The examined extracts and fractions showed higher cytotoxic activity towards cancer cells compared to normal fibroblast MRC5 cells. Morphological evaluation and cell cycle distribution analysis demonstrated their proapoptotic activity in human cervical adenocarcinoma HeLa cells. Fall extract and fractions better suppressed the migration and tube formation of EA.hy926 cells in comparison with summer extract and fractions. Fall extract and fractions were more potent in inhibition of α-glucosidase enzymatic activity. Ethyl-acetate fractions, from both seasons, exhibited the best antibacterial and antifungal activity on all tested bacteria and fungi. In conclusion, the two fall fractions ethyl-acetate and petroleum-ether rich in polyphenols and polyunsaturated fatty acids, were the most active and exhibited prominent anticancer and anti-α-glucosidase activities.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 833-844
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CD25 (IL-2R) expression correlates with the target cell induced cytotoxic activity and cytokine secretion in human natural killer cells
Autorzy:
Rudnicka, Karolina
Matusiak, Agnieszka
Chmiela, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1038939.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
natural killer cells
CD25
cytotoxic activity
granzyme
caspase
cytokines
Opis:
Cytotoxic activity is one of the major functions of Natural Killer (NK) cells and is a critical effector mechanism of innate immune responses against infected or cancer cells. A variety of assays have been developed to determine NK cell cytotoxic activity, however a receptor-based screening tool is still lacking. Here, we propose the CD25 receptor as a candidate for NK cell cytotoxicity marker. We have verified that there is a correlation between classic target cell induced cytotoxicity markers and the CD25 expression on NK cells. Non-adherent lymphocyte fractions pre-stimulated with Escherichia coli O55:B5 lipopolysaccharide were co-cultured with settled HeLa targets in a four hour long cytotoxic assay. The cytotoxic effect was evaluated by MTT reduction assay and quantification of soluble cytotoxicity markers (granzyme B, FasL, caspase-8, IFN-γ and IL-2) was done by ELISA. Lymphocytes were stained with anti-CD3-Cy-5, anti-CD56/CD16/Nkp46-FITC and anti-CD25-PE antibodies and analyzed by flow cytometry. We observed that the CD25 expression exclusively on the CD3-CD56+CD25+ NK cells was positively correlated with their cytotoxic function evaluated by the MTT test (r = 0.68), the upregulation of granzyme B (r = 0.89), IL-2 (r = 0.78) and IFN-γ (r = 0.57), however, it was not positively correlated with FasL and caspase-8. We conclude that the CD25 expression might serve as an in vitro receptor-based screening tool for NK cell activity.
Źródło:
Acta Biochimica Polonica; 2015, 62, 4; 885-894
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chemical Composition, Cytotoxic and Antioxidant Activities of Celosia trigyna L. Grown in Saudi Arabia
Autorzy:
El-Desouky, Samy
Abdelgawad, Ahmed
El-Hagrassi, Ali
Hawas, Usama
Kim, Young-Kyoon
Powiązania:
https://bibliotekanauki.pl/articles/895232.pdf
Data publikacji:
2019-08-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
GC-MS
antioxidant activity
cytotoxic activity
Celosia trigyna
flavonoid-glycosides
Opis:
The methanol extract of the aerial parts of Celosia trigyna (Amaranthaceae) was successively fractionated using n-hexane, dichloromethane, ethyl acetate and n-butanol. The cytotoxic activity of the obtained fractions was investigated using sulphorhodamine-B (SRB) assay against three carcinoma cell lines; breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT-116) and hepatocellular carcinoma cells (HepG2). The dichloromethane fraction showed significant in vitro cytotoxic activities against the human cancer cell lines HCT-116 and HEP-G2 with IC50 values of 10.9 and 11.2 µg/mL, respectively, while all fractions revealed weak antioxidant activity using DPPH free radical scavenging method. The GC-MS analysis of the most cytotoxic dichloromethane fraction has resulted in the identification of 12 compounds. The main constituents were tetrahydroisoquinoline derivative (31.44%), 2,3-dimethylheptadecane (16.71%) and 3-octadecanone (15.56%). Moreover, the phytochemical study of the dichloromethane and n-butanol fractions led to the isolation and identification of five known compounds identified as β-amyrin acetate (1), acacetin 8-C-α-rhamnosyl-(1→2)-β-glucopyranoside (2), apigenin 8-C-α-rhamnosyl-(1→2)-β-glucopyranoside (3), quercetin 3-O-α-rhamnosyl-(1→6)-β-glucopyranoside (4) and 3-hydroxyglutaric acid (5).
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 691-699
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carotenoid composition and in vitro pharmacological activity of rose hips
Autorzy:
Horváth, Györgyi
Molnár, Péter
Radó-Turcsi, Erika
Deli, József
Kawase, Masami
Satoh, Kazue
Tanaka, Toru
Tani, Satoru
Sakagami, Hiroshi
Gyémánt, Nóra
Molnár, József
Powiązania:
https://bibliotekanauki.pl/articles/1039796.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
radical intensity
cytotoxic activity
carotenoids
Rosa canina L.
MDR
anti-H. pylori
Opis:
The aim of the present study was to compare carotenoid extracts of Rose hips (Rosa canina L.) with regard to their phytochemical profiles and their in vitro anti-Helicobacter pylori (H. pylori), cytotoxic, multidrug resistance (MDR) reversal and radical scavenging activity. Carotenoid composition was investigated in the different fractionation of rose hips, using extraction methods. Six main carotenoids - epimers of neochrome, lutein, zeaxanthin, rubixanthin, lycopene, β,β-carotene - were identified from Rose hips by their chromatographic behavior and UV-visible spectra, which is in accordance with other studies on carotenoids in this plant material. The active principles in the carotenoid extract might differ, depending upon the extraction procedures.
Źródło:
Acta Biochimica Polonica; 2012, 59, 1; 129-132
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exploring the potential of Inula viscosa extracts for antioxidant, antiproliferative and apoptotic effects on human liver cancer cells and a molecular docking study
Autorzy:
Kheyar-Kraouche, Naoual
Boucheffa, Saliha
Bellik, Yuva
Farida, Kheyar
Brahmi-Chendouh, Nabila
Powiązania:
https://bibliotekanauki.pl/articles/16706188.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
Inula viscosa leaf extracts
antioxidant
cytotoxic effect
HepG2 cells
ROS
molecular docking
Opis:
In folk medicine, Inula viscosa (Asteraceae) has been traditionally utilized for treating various ailments, including diabetes, bronchitis, diarrhea, rheumatism, and injuries. In this study, we aimed to investigate the chemical composition, antioxidant, antiproliferative, and apoptotic properties of I. viscosa leaf extracts. Extraction was performed using solvents of varying polarities. Antioxidant activity was determined using Ferric reducing antioxidant power (FRAP) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The results revealed that aqueous ethanol (70%) and aqueous ethyl acetate (70%) extracts contained high levels of phenols (645.58 ± 8.77 mg CE/g) and flavonoids (180.69 ± 1.54 mg QE/g), respectively. Aqueous ethanol (70%) extract exhibited the highest antioxidant activity with IC50 of 572.74 μmol TE/g DW (μmol Trolox equivalent in 1g of dry extract) in the ABTS assay and 76 862.06 μM TE/g DW in the FRAP test. All extracts showed a considerable dose-dependent cytotoxic effect on cancerous HepG2 cells (P < 0.05). The aqueous ethanol extract demonstrated the highest inhibitory effect (IC50 = 1.67 mg/ml). Treatment with aqueous ethanol (70%) and pure ethyl acetate extracts significantly increased the number of apoptotic cells to 8 and 6%, respectively, in HepG2 cells (P < 0.05). Additionally, the aqueous ethanol extract significantly elevatedreactive oxygen species (ROS) levels (53%) in HepG2 cells. The molecular docking study identified paxanthone and banaxanthone E as the compounds that exhibited the highest binding affinities with BCL-2. This study demonstrated the potent antioxidant, antiproliferation, and intracellular ROS production of I. viscosa leaf extracts. Further studies should be conducted to identify the active compounds involved.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2023, 104, 2; 183-198
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chemical composition, antimicrobial and cytotoxic activity of essential oils of Algerian Thymus vulgaris L.
Autorzy:
Abdelli, Wafae
Bahri, Fouad
Sysak, Angelika
Szumny, Antoni
Pawlak, Aleksandra
Obmińska-Mrukowicz, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/895715.pdf
Data publikacji:
2019-12-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
essential oil
GC-MS
antimicrobial activity
cytotoxic activity
GC-FID
Thymus vulgaris L
Opis:
This study analyzed chemical composition of the essential oils (EOs) of Thymus vulgaris L., harvested in two regions of northwest Algeria (Tlemcen and Mostaganem), and evaluated their antimicrobial and cytotoxic activity. Fifty one compounds representing 99.99% and 100% of total thyme oil of Mostaganem (EO.TM) and Tlemcen (EO.TT), respectively were identified by GC-FID and GC-MS. Carvacrol was a dominant compound in both oils (89.15 and 82.42%). The antimicrobial activity, demonstrated by disc diffusion and broth macrodilution methods, showed a strong inhibitory effect of the oils on seven reference strains tested and particularly on Bacillus cereus ATCC 10876 and Candida albicans ATCC 10231. A cytotoxicity assay for two normal and two cancer cell lines indicated the highest sensitivity of canine B-cell lymphoma cell line (CLBL-1) for which IC50 values were 35.39 ± 9.0 (EO.TT) and 84.51± 3.2 (EO.TM). Murine fibroblast cell line (3T3), with IC50 116.97 ± 2.7 for EO.TT and 146.29 ± 0.5 for EO.TM was the most resistant line.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1051-1059
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxic, Genotoxic and Apoptotic Activity of Isolated Compound from Pandanus odorattissimus
Autorzy:
Kamble, Abhaykumar
Swamy, Paramjyothi
Powiązania:
https://bibliotekanauki.pl/articles/1161866.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Apoptotic activity
Comet assay
Cytotoxic activity
Human Leukemia 60 (HL-60) cells
Pandanus odorattissimus L
Opis:
The present study reports potential activities like cytotoxic, genotoxic and apoptotic activity of phenolic compound 4-(4-(3,4-dimethoxyphenyl)hexahydrofuro[3,4-c]furan-1-yl)-2-methoxyphenyl acetate isolated from methanolic extract of Pandanus odorattissimus. The compound showed a significant cytotoxic effect on Human Leukemia 60 (HL-60) cell line. Exposure of the compound reduced the viability of HL-60 cells after 12, 24 and 48 hours, the compound exerted a significant cytotoxic effect on HL-60 cells. The compound also induced significant DNA damage. The results of comet assay with pattern of the HL-60 cells has shown an intact head and complete absence of DNA fragments in the form of tail suggesting that the doses are not genototoxic. The phenolic compound at concentration of 20 µg/mL, showed an increase in percentage tail of DNA upto 6.21 units when compared to control 5.35. Although all of the compound induced significant DNA damage it induced apoptotic in the middle level and led to significant level. Apoptotic effect of compound on HL-60 cells after 72 h increased. Furthermore, the compound induced slight necrosis in HL-60 cells. Although the compound induced significant DNA damage, it induced apoptotic at the middle level. Apoptotic effect of compound on HL cells after 72 hrs increased level, furthermore the compound induced slight necrosis in HL-60 cells.
Źródło:
World Scientific News; 2018, 112; 193-206
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioactive metabolites produced by Spirulina subsalsa from the Baltic Sea
Autorzy:
Szubert, K.
Wiglusz, M.
Mazur-Marzec, H.
Powiązania:
https://bibliotekanauki.pl/articles/47501.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:
bioactive metabolite
Spirulina subsalsa
Baltic Sea
Cyanoprokaryota
bioremediation
cytotoxic activity
liquid chromatography-tandem mass spectrometry
protease inhibitor
Źródło:
Oceanologia; 2018, 60, 3
0078-3234
Pojawia się w:
Oceanologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Construction and expression of indonesian hepatitis B core antigen (HBcAg) in Lactococcus lactis as potential therapeutic vaccine
Autorzy:
Anwar, R.I.
Mustopa, A.Z.
Ningrum, R.A.
Sucharsono, S.
Powiązania:
https://bibliotekanauki.pl/articles/81249.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
hepatitis B virus
antigen
Lactococcus lactis
cytotoxic T
immune response
therapeutic vaccination
protein expression
patient
Indonesia
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Isolation and in vitro cytotoxic activity of 11-methylixoside isolated from bark of Randia dumetorum Lamk.
Izolacja i działanie cytotoksyczne in vitro 11-metyliksozydu wyizolowanego z kory Randia dumetorum Lamk.
Autorzy:
Jangwan, J.S.
Aquino, R.P.
Mencherini, T.
Singh, R.
Powiązania:
https://bibliotekanauki.pl/articles/71884.pdf
Data publikacji:
2013
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
isolation
in vitro
cytotoxic activity
11-methylixoside
bark
Randia dumetorum
Rubiaceae
tree
medicinal plant
plant morphology
Opis:
Randia dumetorum (family Rubiaceae) is highly reputed ayurvedic medicinal tree commonly known as the Mainphal. A large deciduous thorny shrub grows up to 5 m of height. It occurs almost throughout India up to 1200 m of altitude. It is found in Himalaya from Jammu East ward ascending to 400 m and from Kashmir to East ward up to 1200 m. 11-methylixoside (compound 1), an iridoid glucoside, was isolated from the bark of this plant. The structure was characterized by using spectroscopic methods including 1D-1HNMR,13C-NMR and 2D-NMR (HSQC,HMBC, DQF-COSY) experiments and confirmed by comparison of their NMR data with those from the literature. This compound has been reported for the first time in Randia dumetorum bark. The 11-methylixoside was subjected to cytotoxic activity against MDA-MB-231 (breast cancer cell line) and SK-MEL-2 (human skin melanoma cell line), BE(2)C (neuroblastoma cell line derived from human bone marrow) and U87MG (human neuronale glioblastoma (astrozytom) cell line showed appreciable cytotoxic effect with IC50 value 63.10 µg/ml concentration for SK-MEL-2 (human skin melanoma cell line).
Randia dumetorum (rodzina Apiaceae) jest rośliną cenioną w medycynie aiurwedyjskiej, znaną pod nazwą Mainphal. Duży, liściasty, ciernisty krzew osiąga wysokość 5 m. Występuje praktycznie w całych Indiach do wysokości 1200 m. Można go znaleźć w Himalajach od Jammu (400 m) do Kaszmiru (1200 m). Z kory tej rośliny wyizolowano glukozyd irydoidowy 11-metyloksyd (składnik 1). Jego strukturę zbadano za pomocą metod spektroskopowych obejmujących 1D-1HNMR,13C-NMR i 2D-NMR (HSQC,HMBC, DQF-COSY) i potwierdzono poprzez porównanie jego NMR danych z danymi literaturowymi. Obecność tego składnika stwierdzono po raz pierwszy w korze Randia dumetorum. Działanie cytotoksyczne 11-metyliksozydu było badane przeciw MDA-MB-231 (linia komórkowa raka sutka) i SK-MEL-2 (linia komórkowa czerniaka), BE(2)C (linia komórkowa neuroblastomy uzyskana z ludzkiego szpiku kostnego) i U87MG (linia komórkowa ludzkiej glioblastomy (gwiaździak). Wykazano znaczne działanie cytotoksyczne z wartością IC50 w stężeniu 63.10 µg/ml przeciw SK-MEL-2 (linia komórkowa czerniaka).
Źródło:
Herba Polonica; 2013, 59, 1
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chemical composition and cytotoxic activity of the polysaccharide fraction in Sarcodon imbricatus (Basidiomycota)
Skład chemiczny i aktywność cytotoksyczna frakcji polisacharydowych Sarcodon imbricatus (Basidiomycota)
Autorzy:
Sulkowska-Ziaja, K.
Muszynska, B.
Ekiert, H.
Powiązania:
https://bibliotekanauki.pl/articles/67690.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
chemical composition
cytotoxic activity
polysaccharide fraction
Sarcodon imbricatus
Basidiomycota
cytotoxicity
breast cancer
mycelium
in vitro culture
qualitative analysis
Opis:
The aim of the study was chemical analysis of polysaccharide fractions from sporocarps of Sarcodon imbricatus collected in natural sites and from the mycelium of in vitro cultures. Three polysaccharide fractions (FOI, FOII, FOIII) were isolated from sporocarps and two (FKI, FKII) from in vitro cultures. Qualitative analysis by HPLC method showed that they are composed of galactose and fucose (FOI, FKI) or glucose and fucose (FOII, FKII). FOIII fraction of the sporocarps consisted of glucose only. Molecular weights of isolated fractions ranged from 3.8 to 16.3 kDa for fractions from the sporocarps and from 5.8 to 14.7 kDa for that ones isolated from in vitro culture. The total percentage of sugar content for all fractions ranged from 97.8% to 99.1%. The percentage of uronic acids contents in acidic fractions was 2.6% and 2.7% for the FOI and FKI respectively. The work included also an assessment of cytotoxic activity of polysaccharide fractions in relation to tumor cell lines of human breast cancer MCV-7. FOI polysaccharide fraction of the sporocarps inhibited the growth of cancer cells in 50% compared to the control at a concentration of 0.0125%, while the polysaccharide fraction FKI from in vitro cultures inhibited cell growth in a concentration of 0.016%.
Przedstawiciele gromady Basidiomycota – której reprezentantem jest Sarcodon imbricatus (L.: Fr.) P. Karst., są ważnym źródłem związków aktywnych biologicznie. W ich owocnikach wykryto m.in. związki o działaniu przeciwwirusowym, przeciwbakteryjnym, fungistatycznym, a także przeciwnowotworowym. Najlepiej poznanymi metabolitami grzybowymi są polisacharydy. Coraz częściej podejmowane są badania nad składem chemicznym nie tylko owocników, ale także grzybni pozyskanej z kultur in vitro. W badaniach z tego zakresu dowiedziono istnienia jakościowych i ilościowych różnic w produkcji niektórych grup związków chemicznych przez owocniki i grzybnię z kultur in vitro. Obiektem przeprowadzonych badań były owocniki Sarcodon imbricatus zebrane na terenie lasów świerkowych w roku 2008. Z warstwy hymenialnej owocnika wyprowadzono kultury in vitro, które prowadzono, jako płynne, wytrząsane. W ramach przeprowadzonych badań wyizolowano 3 frakcje polisacharydowe (FOI, FOII, FOIII) z owocników i 2 (FKI, FKII) z mycelium z kultur in vitro. Analiza jakościowa z wykorzystaniem metody HPLC wykazała, że składają się one z galaktozy i fruktozy (FOI, FKI) oraz glukozy i fruktozy (FOII, FKII). Frakcja FOIII z owocników składała się wyłącznie z glukozy. Oznaczono masy cząsteczkowe wyizolowanych frakcji. Wynosiły one od 3.8 do 16.3 kDa dla frakcji z owocników i od 5.8 do 14.7 kDa dla frakcji z kultur in vitro. Całkowita procentowa zawartość cukrów dla wszystkich frakcji mieściła się w przedziale od 97.8% do 99.1%, natomiast procentowa zawartość kwasów uronowych we frakcjach o charakterze kwaśnym wynosiła 2.6% dla frakcji FOI z owocników i 2.7% dla frakcji FKI z kultur in vitro. Druga część pracy obejmowała ocenę aktywności cytotoksycznej wybranych frakcji polisacharydowych w stosunku do linii komórek nowotworowych ludzkich raka sutka MCV-7 w teście in vitro. Frakcje polisacharydowe FOI i FKI wykazywały działanie hamujące na komórki nowotworowe. Frakcja polisacharydowa FOI z owocników hamowała wzrost komórek nowotworowych w 50% w stosunku do próby kontrolnej w stężeniu 0.0125%, natomiast frakcja polisacharydowa FKI z kultur in vitro hamowała wzrost komórek w stężeniu 0.016%.
Źródło:
Acta Mycologica; 2012, 47, 1
0001-625X
2353-074X
Pojawia się w:
Acta Mycologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In silico and in vitro cytotoxic effect of prodigiosin-conjugated silver nanoparticles on liver cancer cells (HepG2)
Autorzy:
El-Batal, A.I.
El-Hendawy, H.H.
Faraag, A.H.I.
Powiązania:
https://bibliotekanauki.pl/articles/80210.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
silver nanoparticle
liver cancer
cancer cell line
HepG2 cell
Serratia marcescens
cytotoxic activity
in silico analysis
mitogen-activated protein kinase
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2017, 98, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of selected plant extracts on the mitochondria of leukemic cancer cells in vitro
Wpływ wybranych wyciągów roślinnych na mitochondria białaczkowych komórek nowotworowych in vitro
Autorzy:
Tomečková, V.
Stupák, M.
Mojžišová, G.
Šutorová, M.
Mašlanková, J.
Powiązania:
https://bibliotekanauki.pl/articles/271488.pdf
Data publikacji:
2013
Wydawca:
Górnośląska Wyższa Szkoła Pedagogiczna im. Kardynała Augusta Hlonda
Tematy:
synchronous fluorescence fingerprint
fluorescence
mitochondria
arnika
hops
horse chestnut
cytotoxic effect
leukemic cells
fluorescencja
arnica
chmiel
kasztanowiec
efekt cytotoksyczny
białaczkowe komórki nowotworowe
Opis:
Individual plant extracts from horse chestnut, arnica and hops have been applied in vitro on Jurkat type leukemic cells from which mitochondria were isolated. Each sample of the isolated experimental mitochondria were monitored by the determination of proteins and by monitoring the fluorescence of endogenous fluorophores of experimental mitochondria compared with control mitochondria isolated from intact leukemic cells by means of the synchronous fluorescence fingerprint method. The horizontal cut of excitation-emission matrices at (λ = 240 nm) demonstrated the final graphical and mathematical fluorescence of mitochondria. The result is the presence of two fluorescent excitation-emission zones (the result of the overlapping effect of very similar fluorescence maxima values), which were subsequently compared with standard fluorophores. A reduction of protein content in all experimental mitochondria was observed, the most after the effect of arnica and the least after the influence of horse chestnut. The decrease of fluorescence of the first fluorescent zone was compared to control mitochondria. The decline of mitochondrial fluorescence confirmed the cytotoxic effect of the substances studied on the mitochondria in vitro.
Oceniono wpływ in vitro wyciągów wybranych roślin (kasztanowiec, chmiel, arnica) na mitochondria wyizolowane z nowotworowych komórek białaczkowych typu Jurkat. Każdą próbkę wyizolowanych eksperymentalnie mitochondriów monitorowano określając produkowane białka i oceniając fluorescencję endogennych fluoroforów z użyciem metody the synchronous fluorescence fingerprint i porównano z mitochondriami kontrolnymi uzyskanymi z komórek nie poddanych oddziaływaniu wyciągów. Odczyty wskazań emisji macierzy falą o długości (λ = 240 nm) ukazały fluorescencję mitochondriów. Stwierdzono dwie emisje, które porównano ze standardowymi fluorophorami. Zobrazowano redukcję zawartości białka we wszystkich doświadczalnych mitochondriach, największą po wyciągach z arnica i najmniejszą po kasztanowcu. Obniżenie fluorescencji pierwszej strefy było porównywalne z mitochondriami kontrolnymi. Obniżenie mitochondrialnej fluorescencji potwierdza cytotoksyczny efekt badanych substancji na mitochondia in vitro.
Źródło:
Journal of Ecology and Health; 2013, R. 17, nr 4, 4; 186-190
2082-2634
Pojawia się w:
Journal of Ecology and Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vitro cultures of carnivorous plants from the Drosera and Dionaea genus for the production of biologically active secondary metabolites
Autorzy:
Banasiuk, R.
Kawiak, A.
Krolicka, A.
Powiązania:
https://bibliotekanauki.pl/articles/80172.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
antimicrobial activity
antioxidant
cytotoxic activity
flavonoids
micropropagation
naphthoquinone
in vitro culture
carnivorous plant
Drosera
extract
phytotherapy
pulmonary disease
cough
biological activity
secondary metabolite
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
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