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Tytuł:
Podstawowe objawy i różnicowanie nieswoistych chorób zapalnych jelit
Basic symptoms and differentiation of inflammatory bowel diseases
Autorzy:
Wojtuń, Stanisław
Gil, Jerzy
Szwed, Łukasz
Dyrla, Przemysław
Powiązania:
https://bibliotekanauki.pl/articles/1033264.pdf
Data publikacji:
2014
Wydawca:
Medical Communications
Tematy:
Crohn’s disease
endoscopy
gastrointestinal diseases
treatment
ulcerative colitis
choroby przewodu pokarmowego
choroba leśniowskiego-crohna
wrzodziejące zapalenie jelita
grubego
endoskopia
leczenie
Opis:
Ulcerative colitis (colitis ulcerosa, CU) and Crohn’s disease belong to a group of nonspecific inflammatory bowel diseases characterized by chronicity and unknown aetiology. Due to their heterogeneous pathogeneses, their clinical pictures and clinical courses vary. This results in diagnostic difficulties that are encountered despite the availability of a number of specialized tests in contemporary medicine. It is known that a condition necessary to establish a definitive diagnosis is to confirm the presence of a nonspecific inflammatory bowel disease in a histopathological examination, but laboratory tests are helpful in the initial diagnosis and demonstrate the extent and severity of the inflammatory process. C-reactive protein is the indicator of the inflammatory process, and anaemia that occurs in ulcerative colitis is due to both the chronicity of the disease and iron deficiency secondary to blood loss. Laboratory diagnosis is also applicable in the evaluation of parenteral complications concerning the liver, bile ducts, and osteoporosis. Abnormal liver function tests are frequent in inflammatory bowel diseases and may be caused by an ongoing inflammatory process typical of these diseases as well as by the pharmacological treatment implemented. Although new methods, such as computed tomography, magnetic resonance imaging and positron emission tomography, are used in diagnosing gastrointestinal diseases, endoscopy with histopathological analysis of the collected samples still is (and will be for a long time) a primary diagnostic method in the process of diagnosing, monitoring the course of treatment and oncological surveillance.
Wrzodziejące zapalenie jelita grubego i choroba Leśniowskiego-Crohna należą do grupy nieswoistych chorób zapalnych jelit o przewlekłym przebiegu i nieznanej etiologii. Z uwagi na niejednorodną patogenezę mają zróżnicowany obraz i przebieg kliniczny, co powoduje trudności diagnostyczne pomimo dostępności wielu wielospecjalistycznych badań. Wiadomo, że warunkiem koniecznym ustalenia ostatecznego rozpoznania jest potwierdzenie nieswoistej choroby zapalnej jelit w badaniu endoskopowym i histopatologicznym, niemniej jednak badania laboratoryjne są pomocne we wstępnej diagnostyce i odzwierciedlają zasięg oraz nasilenie procesu zapalnego. Białko C-reaktywne stanowi wykładnik procesu zapalnego, a występująca we wrzodziejącym zapaleniu jelita grubego niedokrwistość jest wynikiem zarówno przewlekłości choroby, jak i niedoboru żelaza wtórnego do utraty krwi. Diagnostyka laboratoryjna ma również zastosowanie w ocenie powikłań pozajelitowych dotyczących wątroby i dróg żółciowych, a także osteoporozy. Nieprawidłowe wyniki prób wątrobowych są częste w chorobach zapalnych jelit i mogą być spowodowane procesem zapalnym typowym dla tych chorób, ale też stosowanym leczeniem farmakologicznym. Chociaż powstają nowe metody wykorzystywane w diagnostyce przewodu pokarmowego, takie jak tomografia komputerowa, rezonans magnetyczny, pozytronowa tomografia emisyjna, to jednak badanie endoskopowe z oceną histopatologiczną pobranych wycinków jest (i jeszcze długo będzie) podstawową metodą diagnostyczną w rozpoznawaniu, monitorowaniu leczenia oraz nadzorze onkologicznym.
Źródło:
Pediatria i Medycyna Rodzinna; 2014, 10, 1; 61-66
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Results of home parenteral nutrition in patients with severe inflammatory bowel disease – an alternative for surgery of malnourished patients
Autorzy:
Turkot, Maryla
Sobocki, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1393286.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
home parenteral nutrition
inflammatory bowel disease
nutrition
Crohn’s disease
colitis ulcerosa
Opis:
Introduction: In the world, the inflammatory bowel disease affects an increasing number of younger and younger patients, and in some of them parenteral nutrition is an alternative to high-risk surgical intervention due to advancement of the disease and malnutrition. Aim: The aim of the study was to assess the results of home parenteral nutrition in patients with severe bowel inflammatory disease, in whom surgical treatment is associated with high risk of complications. Materials and methods: A retrospective analysis was conducted on 46 patients, who received home parenteral nutrition instead of another surgical intervention. The inclusion criteria included home parenteral nutrition and diagnosis of Crohn’s disease or ulcerative colitis. Results: Mean number of complications requiring hospital admission per patient was 1.76, the BMI increased by 4.3 on average [kg/m2]. During parenteral nutrition, the percentage of patients, in whom anti-inflammatory or immunosuppressant drugs were completely discontinued, was 17.4%. In the whole group, at least one immunosuppressive drug was discontinued in onefifth of patients. Mean albumin level increased by 2.4 g/L, lymphocyte count dropped by 474 lymphocytes/mm3, and leukocyte count increased by 747.6/mm3. The patients described their condition as good in 87%, and 7.4% of patients were able to work. Conclusions: Home parenteral nutrition positively affects patient’s general condition by increasing BMI and normalizing biochemical test results. The results indicate the need to consider this method as an alternative to surgical intervention in severe bowel inflammatory disease with high perioperative risk, which could reduce the complication rate.
Źródło:
Polish Journal of Surgery; 2017, 89, 5; 23-28
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental inflammatory bowel disease - role of T cells
Autorzy:
Szczepanik, M.
Gryglewski, A.
Bryniarski, K.
Stachura, J.
Ptak, W.
Powiązania:
https://bibliotekanauki.pl/articles/70282.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
myeloperoxidase
B lymphocyte
inflammatory bowel disease
chronic colitis
colitis
T cell
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie obrazowania autofluorescencyjnego w diagnostyce chorób jelita grubego ‒ aktualny stan wiedzy
The usefulness of autofluorescense imaging in the diagnosis of colorectal diseases ‒ current state of knowledge
Autorzy:
Strzelczyk, N.
Kwiatek, S.
Latos, W.
Sieroń, A.
Stanek, A.
Powiązania:
https://bibliotekanauki.pl/articles/261397.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
Tematy:
obrazowanie autofluorescencyjne
wskaźnik wykrywania gruczolaków
rak jelita grubego
wrzodziejące zapalenie jelita grubego
chłoniak jelita grubego
autofluorescence imaging
adenoma detection rate
colorectal cancer
colitis ulcerosa
colorectal lymphoma
Opis:
Kolonoskopia światła białego jest złotym standardem w diagnostyce chorób jelita grubego, jednak wciąż poszukiwane są metody, które umożliwią szybsze i bardziej precyzyjne stawianie rozpoznań. Jedną z tych metod jest obrazowanie autofluorescencyjne. Wykorzystuje ono zjawisko wzbudzania przez światło endogennie występujących w tkankach fluoroforów. Tkanki nowotworowe i zmienione zapalnie wykazują odmienną autofluorescencję niż tkanki zdrowe, co pozwala na ich różnicowanie. Istnieje wiele prac wykazujących korzyści z zastosowania autofluorescencji w diagnostyce chorób jelita grubego. Zwiększa ona współczynnik wykrywania polipów, umożliwia ocenę charakteru histopatologicznego zmiany w trakcie kolonoskopii, zwiększa dokładność oceny stopnia nasilenia wrzodziejącego zapalenia jelita grubego oraz ułatwia wykrywanie ognisk neoplazji u pacjentów z nieswoistymi zapaleniami jelit, a także zwiększa wykrywalność zmian o charakterze chłoniaka. Obrazowanie autofluorescencyjne przyczynia się do szybkiego i precyzyjnego postawienia rozpoznania oraz wcześniejszego włączenia odpowiedniego leczenia.
White light colonoscopy is the gold standard in the diagnostics of colorectal diseases, however new methods that will allowed faster and more precise diagnosis are still sought. One of these methods is autofluorescence imaging. It uses the phenomenon of light excitation of endogenous fluorophores in tissues. Autofluorescence of normal tissue differs from that characteristic of inflamed or neoplastic tissues, which allows their differentiation. There are many studies showing the benefits of autofluorescence imaging in the diagnosis of colon diseases. It improves polyp detection rate, makes it possible to assess histopathological severity of the lesion during colonoscopy, improves the evaluation of ulcerative colitis severity, facilitates the detection of colorectal neoplasia in patients with inflammatory bowel disease, and improves the detection of lymphoma lesions. Autofluorescence imaging contributes to the fast and precise diagnosis and the early initiation of appropriate treatment.
Źródło:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2018, 24, 1; 40-48
1234-5563
Pojawia się w:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sleep disturbance and disease activity in adult patients with inflammatory bowel diseases
Autorzy:
Sobolewska-Wlodarczyk, A.
Wlodarczyk, M.
Banasik, J.
Gasiorowska, A.
Wisniewska-Jarosinska, M.
Fichna, J.
Powiązania:
https://bibliotekanauki.pl/articles/70043.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
sleep disturbance
inflammatory bowel disease
Crohn's disease
ulcerative colitis
disease activity
inflammatory disease
patient
Źródło:
Journal of Physiology and Pharmacology; 2018, 69, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Retrospective analysis of hospital admissions of patients with ulcerative colitis and Crohns disease from semi-rural and rural regions in the Department of Gastroenterology in Lublin between 2000-2006
Autorzy:
Skrzydlo-Radomanska, B
Radwan, P.
Radwan-Kwiatek, K.
Powiązania:
https://bibliotekanauki.pl/articles/49439.pdf
Data publikacji:
2008
Wydawca:
Instytut Medycyny Wsi
Tematy:
rural region
ulcerative colitis
Crohn's disease
retrospective analysis
human disease
hospital
patient
inflammatory bowel disease
Źródło:
Annals of Agricultural and Environmental Medicine; 2008, 15, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Impact of the Nutritional State of Patients on the Results of the Surgical Treatment of Ulcerative Colitis
Autorzy:
Skowrońska-Piekarska, Urszula
Matysiak, Konrad
Sowińska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1396201.pdf
Data publikacji:
2013-08-01
Wydawca:
Index Copernicus International
Tematy:
ulcerative colitis
nutritional assessment
undernutrition
surgery
length of stay
Opis:
A variety of mechanisms have been proposed to explain the malnutrition and body mass loss in UC patients. The aim of the study trial was a nutritional state assessment of 347 UC patients, admitted for surgical treatment, and the evaluation of the impact of this state on the postoperative course in this group of patients. Material and methods. We referred the results of nutritional state assessment to the length of time of postoperative hospitalization of patients. Results. Through application of the Kruskal-Wallis test we found statistically significant, but weakly expressed, differences between the values of nutritional state parameters and period of hospitalization of patients. The applied U Mann-Whitney test, with statistically significant results with p <0.05, showed statistically significant differences between cured and dead subgroups in: 1) loss of body mass in 6 months before hospitalization (p = 0.000033), 2) hemoglobin level (p = 0.006676), 3) total lymphocyte count (TLC) (p = 0.025242), 4) total serum protein level (p = 0.003485), 5) serum albumin level (p =0.00165). Differences in BMI values were statistically negligible (p = 0.969397). Conclusions. The body mass loss in 6 months before admission, total lymphocyte count and serum albumin level are the reference parameters of the nutritional state of UC patients on admission to surgery
Źródło:
Polish Journal of Surgery; 2013, 85, 8; 424-432
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnosis and treatment difficulties in 18-year-old male patient with hereditary hemochromatosis, chronic hepatitis B, Gilbert syndrome and ulcerative colitis
Autorzy:
Sikorska, Katarzyna
Liberek, Anna
Romanowski, Tomasz
Szlagatys-Sidorkiewicz, Agnieszka
Landowski, Piotr
Bielawski, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1039929.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hereditary hemochromatosis
ulcerative colitis
chronic hepatitis B
Glibert syndrome
Opis:
Among possible causes of chronic hepatitis in adolescents most common are infections, autoimmune disorders and metabolic diseases. Thus, diagnostic procedures should be multidirectional. This study reports diagnosis and treatment difficulties in an 18-year-old male patient with hereditary hemochromatosis (HH), ulcerative colitis (UC), chronic hepatitis B (CHB) and Gilbert syndrome. The presented case illustrates problems in diagnostics related to the presence of numerous disease conditions in one patient. It should be taken into consideration that these diseases coexisting in one patient can mutually affect their symptoms creating specific diagnostic difficulties.
Źródło:
Acta Biochimica Polonica; 2011, 58, 2; 251-254
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quality of Life Considering Patients with Chronic Inflammatory Bowel Diseases - Natural and Parenteral Nutrition
Autorzy:
Raczkowska, Aneta
Ławiński, Michał
Gradowska, Aleksandra
Zielińska-Borkowska, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/1395848.pdf
Data publikacji:
2014-12-18
Wydawca:
Index Copernicus International
Tematy:
Crohn's disease
ulcerative colitis
quality of life
Opis:
One of the elements of treatment considering inflammatory bowel diseases is nutritional therapy. The duration of the above-mentioned depends on the prevalence of such symptoms as fever, bowel move-ments, length of the functioning gastrointestinal tract, stoma and intestinal fistula presence. Nutritional therapy is an essential element of successful treatment alongside pharmacological, surgical, and biological therapy, as well as other methods. Crohn's disease and ulcerative colitis considered as chronic diseases, lead towards physical and biopsychosocial disability, being responsible for the reduction in the quality of life. The aim of the study was to determine the quality of life after surgical procedures in case of patients diagnosed with Crohn's disease and ulcerative colitis, subjected to natural and parenteral nutrition. Material and methods. The study group comprised 52 patients from the Department of Gastroen-terology, Military Medical Institute, and Department of Surgery and Clinical Nutrition, Clinical Hospital in Warsaw. The study was performed between October, 2011 and April, 2012. The World Health Organization Quality of Life Instrument - Bref (WHOQOL-BREF) questionnaire was used to deter-mine the patients’ quality of life. conclusions. A lower quality of life was observed in case of patients subjected to parenteral nutrition, poor education, disease symptoms exacerbation, in the majority-rural inhabitants. The quality of life does not depend on gender, type of disease, family status, and additional medical care.
Źródło:
Polish Journal of Surgery; 2014, 86, 9; 410-417
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Probiotics in the treatment of gastrointestinal diseases
Autorzy:
Przerwa, F.
Kukowka, A.
Kotrych, K.
Uzar, I.
Powiązania:
https://bibliotekanauki.pl/articles/2049330.pdf
Data publikacji:
2021
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
gastrointestinal disease
irritable bowel syndrome
gastroesophageal reflux
peptic ulcer disease
ulcerative colitis
treatment
microbiota
probiotic
probiotyki
choroby układu pokarmowego
mikrobiota
Opis:
The human microbiota has a tremendous effect on our health. In the last decades, our knowledge about interactions between bacteria and humans have grown greatly. Not only is it necessary for humans to synthesize vitamins, to have tight intestinal barriers or protect from pathogens, it also has an impact on our immune system and thus plays an important role in autoimmune diseases and prevention of excessive inflammatory response. The idea of probiotics is to restore the balance in humans digestive microbiota. There is a growing number of scientific papers that proves a positive impact of using probiotics in various diseases. However, there are still questions that need to be answered before probiotics play a bigger role in the treatment. This paper presents the information about the use of probiotics in most common diseases of gastrointestinal tract.
Źródło:
Herba Polonica; 2021, 67, 2; 39-48
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transcriptional changes between uninflamed ulcerative colitis and familial adenomatous polyposis pouch mucosa can be attributed to an altered immune response
Autorzy:
Paziewska, Agnieszka
Horbacka, Karolina
Goryca, Krzysztof
Mikula, Michal
Jarosz, Dorota
Dabrowska, Michalina
Krokowicz, Piotr
Karon, Jacek
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1039136.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ulcerative colitis
familial adenomatous polyposis
pouch
gene expression
immune response
Opis:
A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and some patients with ulcerative colitis (UC). However, this surgical treatment is often associated with pouchitis, a long-term complication that occurs mostly in UC patients. The purpose of this study was to better define the molecular background of pouchitis. A microarray-based survey was performed using pouch mucosal samples collected from 28 and 8 patients undergoing surgery for UC and FAP, respectively. There were 4,770 genes that significantly differentiated uninflamed from inflamed mucosal samples, and their functional features were represented mostly by metabolic and cell proliferation pathways. In contrast, functional analyses of aberrantly expressed genes between UC and FAP samples, irrespective of mucosal inflammation status, revealed multiple pathways and terms that were linked to changes in immune response. Interestingly, the comparison of uninflamed UC and FAP samples identified a set of 29 altered probe sets, including an inflammation-related transcript encoding a Charcot-Leyden crystal (CLC) protein. The most distinct changes in gene expression profiles differentiating uninflamed UC and FAP pouch mucosal samples were attributed to the Gene Ontology category innate immune response. Our study confirmed that alterations in immune responses can be found between patients who underwent surgery for UC and FAP, independent of the pouch inflammation status. This observation may be important when managing IPAA patients.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 69-75
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inflammatory bowel disease: clinical aspects
Autorzy:
Pasternak, Grzegorz
Aebisher, David
Filip, Rafał
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454879.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
inflammatory bowel diseases Leśniowski-Crohn’s disease ulcerative colitis
mataloproteinases
Opis:
Introduction. Inflammatory bowel disease is a complex disease which arises as a result of an interaction between environmental and genetic factors leading to immunological responses and inflammation in the intestine. Aim. To review medical approaches used in inflammatory bowel disorders. Materials and methods. An analysis of literature regarding inflammatory bowel diseases, Leśniowski-Crohn’s disease, ulcerative colitis and mataloproteinases. Results. Current evidence suggests that patients with inflammatory bowel disease may have an elevated risk of endothelial dysfunction and coronary artery disease. Over the past two decades, great advances have been made in our understanding of the interplay between the inflammatory bowel disease. Conclusions. Inflammatory bowel diseases are increasing in Europe. The diagnosis is usually confirmed by biopsies on colonoscopy
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 341-345
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ulcerative colitis: effect on fertility and pregnancy
Autorzy:
Ouzounιdou, A.
Koukourikos, K.
Kourkouta, L.
Tsaloglidou, A.
Powiązania:
https://bibliotekanauki.pl/articles/1917296.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
ulcerative colitis
Pregnancy
Fertility
Reproduction
inflammatory bowel disease
Opis:
Introduction: Ulcerative colitis is one of the most interesting nosological entities of gastroenterology and internal medicine. This chronic autoimmune disorder of the digestive system, along with Crohn's disease, is a type of idiopathic inflammatory bowel disease. It mainly affects people during their peak reproductive age, i.e., 15 to 30 years old. It is characterized by diffuse mucosal inflammation of the large intestine, which is limited to the colon and shows alternating periods of exacerbations and remissions. Purpose: To review the world literature regarding the impact of the disease on fertility, the course of pregnancy, and consecutively, the outcome of pregnancy.Materials and methods: An extensive review of the recent national and international literature in electronic databases (Pubmed, Google Scholar) and in scientific journals was accomplished through the use of appropriate keywords. Results: The majority of women will have a chance of conceiving. For about 25% of them, conception will be achieved in the course of the disease and it will progress normally, resulting in a healthy fetal outcome. Infertility only occurs among men while they are taking medicines, whereas among women it occurs after surgery for ileoanal anastomosis. During periods of flare-ups, there is a possibility of spontaneous abortion, premature labor and birth of an infant with low birth weight. The majority of pharmaceutical formulations can be used safely both before and after pregnancy without causing any birth defects.
Źródło:
Progress in Health Sciences; 2015, 5, 1; 185-191
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The expression of apoptosis-related proteins in patients with ulcerative colitis
Autorzy:
Niewiarowska, K.
Lebelt, A.
Gryko, M.
Pryczynicz, A.
Famulski, W.
Czyżewska, J.
Kemona, A.
Piekarska-Dymicka, V.
Jagodzińska, D.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1916338.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Ulcerative colitis
Bcl-xl
Bax
Bid
Bcl-2
Opis:
Purpose: Recent literature data indicate a key role of apoptosis in the pathogenesis of inflammatory bowel disease. The aim of the study was to evaluate the expression of Bax, Bid, Bcl-2 and Bcl-xl in non-dysplastic and dysplastic epithelium in inflamated mucosa of patients with ulcerative colitis. Methods: The study consists of 18 patients with diagnosed ulcerative colitis. The expression of proteins was determined immunohistochemically. Results: Lack of Bax expression in normal epithelium of the inflamed intestinal mucosa (94.4%) and a weak expression of this protein were found in dysplastic glandular cells (67%). The Bax expression of dysplastic epithelium correlates with reduced severity of chronic inflammation (p<0.005). Bid expression in non-dysplastic glands was found in 67% of cases vs. 16% in dysplastic epithelium that was associated with the occurrence of epithelial erosions or ulcers (p<0.05). Moderate cytoplasmic expression of Bcl-xl was noted in 27.7% of patients in normal epithelium and in 66.1% within dysplastic lesions. Bcl-xl expression in dysplastic glandular cells correlated with the presence of neutrophils in the lamina propria (p <0.05). Conclusions: The immunohistochemical expressions of Bax, Bcl-2 and Bcl-xl increase and Bid protein expression decreases in dysplastic glandular tubes as compared to non-dysplastic intestinal epithelium in inflamed mucosa, which may suggest an imbalance of controlled cell death in ulcerative colitis.
Źródło:
Progress in Health Sciences; 2014, 4, 1; 75-82
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activation of dendritic cells by nematode antigens during colitis
Autorzy:
Maruszewska-Cheruiyot, M.
Donskow-Lysoniewska, K.
Piechna, K.
Powiązania:
https://bibliotekanauki.pl/articles/5777.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
dendritic cell
activation
nematode
antigen
colitis
Źródło:
Annals of Parasitology; 2016, 62, Suppl.
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł

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