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Wyświetlanie 1-15 z 237
Tytuł:
Pathophysiological roles of ERα in the ER signaling mediated oncogenesis of breast cancer
Autorzy:
Abda Neja, Sultan
Powiązania:
https://bibliotekanauki.pl/articles/2040136.pdf
Data publikacji:
2020-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast, cancer
estrogen receptor alpha
oncogenesis
Opis:
Introduction. Estrogen receptors (ER) are members of nuclear receptors that act in the ER signaling pathway regulating the pathophysiology of hormone-responsive target cells including breast tissue. Aim. This detailled review literature was written on the pathophysiology of ER signaling as well as the effect altered ERα and associated pathway derangement in the oncogenesis of breast cancer. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Analysis of the literature. In this pathway, estrogen receptor alpha (ERα) is a key estradiol-17β (E2) induced transcription factor that has been implicated in the initiation and development of the major fraction of breast cancers. Hence understanding the ERα-mediated ER signaling that results in alterations from normal phenotypic features of breast tissue to the oncogenic features of breast cancer is important. The oncogenic effect of ERα in ER signaling is driven by combinations of molecular assets within the cancer cells. Normally, the transcriptional activity of ERα is controlled by tight regulation of its protein level inside the cells. Altered stability and activity of ERα due to its phosphorylation, ubiquitination, glycosylation, sumoylation, and acetylation events can trigger oncogenic ER signaling. Conclusion. The function and activity of ERα is also modulated by its interaction with coregulators as well as crosstalk with oncogenic factors from other oncogenic pathways. These all events increase the complexity of the progression of ER+ breast cancer and its response to endocrine therapy
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 4; 289-302
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical and Psychological Complications of Mastectomy: The Role of Physioterapy
Autorzy:
Adesina, Miracle A.
Olajire, Tolulope I.
Powiązania:
https://bibliotekanauki.pl/articles/1031754.pdf
Data publikacji:
2020
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Mastectomy
breast cancer
physical complications
physiotherapy
psychological complications
Opis:
Breast cancer affects a large number of women worldwide. Surgical management has evolved towards mastectomies and breast-conserving surgeries. The complications following a mastectomy can be physical and/or psychological. The physical complications include pain, scarring, lymphedema, limitation in range of motion at the shoulder, muscle weakness, change in body posture, etc. Some of the psychological complications are negative boy image, anxiety, depression and depressive disorders, negative body image. Appropriate management requires a multi-disciplinary team of which the physiotherapist is a part of. Literature has shown that there is a better improvement in physical function if physiotherapy is commenced early. Therefore, physiotherapy should be incorporated pre and post-mastectomy. Physiotherapy management should focus on lymphatic drainage, soft tissue mobilization, range of motion exercises, strengthening exercises and postural correction. Increased physical activity and recommendation of support groups can help to improve psychological outcomes. It is the role of the physical therapist to deal with the physical and psychological complications of a mastectomy to improve the quality of life of the patients.
Źródło:
World News of Natural Sciences; 2020, 29, 3; 212-224
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Numerical Simulation of Breast Cancer in the Early Diagnosis with Actual Dimension and Characteristics Using Photoacoustic Tomography
Autorzy:
Ahangar Darband, Maryam
Najafi Aghdam, Esmaeil
Gharibi, Arash
Powiązania:
https://bibliotekanauki.pl/articles/31339923.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
photoacoustic
PA
photoacoustic imaging
PAI
photoacoustic tomography
breast cancer
early diagnosis
Opis:
A numerical study and simulation of breast imaging in the early detection of tumors using the photoacoustic (PA) phenomenon are presented. There have been various reports on the simulation of the PA phenomenon in the breast, which are not in the real dimensions of the tissue. Furthermore, the different layers of the breast have not been considered. Therefore, it has not been possible to rely on the values and characteristics of the resulting data and to compare it with the actual state. Here, the real dimensions of the breast at three-dimensional and different constituent layers have been considered. After reviewing simulation methods and software for different stages of the PA phenomenon, a single suitable platform, which is commercially available finite element software (COMSOL), has been selected for simulating. The optical, thermal, elastic, and acoustic characteristics of different layers of breast and tumor at radiated laser wavelength (800 nm) were accurately calculated or obtained from a reliable source. Finally, by defining an array of 32 ultrasonic sensors on the breast cup at the defined arcs of the 2D slices, the PA waves can be collected and transmitted to MATLAB software to reconstruct the images. We can study the resulting PA wave and its changes in more detail using our scenarios.
Źródło:
Archives of Acoustics; 2023, 48, 1; 25-38
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of treatment exposure on diabetes biomarkers among Jordanian breast cancer women: a connection through FBG, C-peptide and HOMA-IR
Wpływ leczenia na biomarkery cukrzycy u kobiet z rakiem piersi w Jordanii: związek z glikemią na czczo, peptydem C i wskaźnikiem HOMA-IR
Autorzy:
Al-Zeidaneen, Safaa A.
Ahmad, Mousa N.
Al-Ebuos, Ali D.
Powiązania:
https://bibliotekanauki.pl/articles/1029513.pdf
Data publikacji:
2017
Wydawca:
Medical Communications
Tematy:
C-peptide
breast cancer stage
fasting blood glucose
menopausal status
treatment exposure
Opis:
Background: Breast cancer is the most frequently occurring and life-threatening malignant tumor in women. The evidence that associates diabetes’ biomarkers with breast cancer is highly controversial. Aims: To evaluate diabetes’ biomarkers in breast cancer patients according to type of treatment exposure, breast cancer severity and menopausal status. Material and methods: A total of 396 breast cancer patients aged between 25 and 65 years attending breast cancer clinics were evaluated. The experimental design permitted to include 134 newly-diagnosed breast cancer patients who were not exposed to any type of interventions and 262 recently diagnosed breast cancer patients (up to three months). Recently, group members were subdivided in two subgroups to control exposure to therapy specially chemotherapy. The patients were further divided according to breast cancer stages and postmenopausal status. Diabetes biomarkers consisted of fasting blood glucose (FBG), C-peptide and HOMA-IR. Results: The high FBG was more prevalent in advance (24.1%) than early (10.6%) stage breast cancer. Compared with premenopausal breast cancer patients, postmenopausal breast cancer patients had higher prevalence of abnormal FBG (21.0% vs. 11.1%). The differences were also significant in the mean of FBG (103.0 ± 1.5 vs. 89.0 ± 0.0 mg/dL). In postmenopausal breast cancer patients, FBG was higher in the recently diagnosed whom expose to treatments including chemotherapy (106.5 ± 1.7 mg/dL vs. 126.2 ± 1.2 mm Hg) compared to the newly-diagnosed group whom not yet expose to any kind of treatment interventions. Conclusion: Diabetes was prevalent among breast cancer patients and it was higher in postmenopausal and advanced stage breast cancer women. The burden of diabetes on treatment expose breast cancer women tend to be high and warrants closer attention by health care provider to improved outcomes after diagnosis and treatment exposure.
Wstęp: Rak piersi to najczęstszy zagrażający życiu nowotwór złośliwy u kobiet. Doniesienia dotyczące związku cukrzycy z rakiem piersi są wysoce kontrowersyjne. Cele: Analiza biomarkerów cukrzycy u pacjentek z rakiem piersi w zależności od ekspozycji na leczenie, stopnia zaawansowania nowotworu i statusu menopauzalnego. Materiał i metody: Do badania włączono 396 pacjentek z rakiem piersi w wieku od 25 do 65 lat, które zgłosiły się do klinik specjalizujących się w leczeniu tej choroby. Plan badania dopuszczał włączenie 134 pacjentek z nowo rozpoznanym nowotworem, które nie otrzymały jeszcze leczenia w żadnej postaci, oraz 262 pacjentek z nowotworem rozpoznanym w ciągu ostatnich trzech miesięcy. Następnie uczestniczki podzielono na dwie podgrupy w celu kontroli ekspozycji na leczenie, szczególnie chemioterapię. Pacjentki podzielono także na podstawie stopnia zaawansowania nowotworu i statusu menopauzalnego. Oceniono następujące biomarkery cukrzycy: glikemię na czczo, peptyd C oraz wskaźnik HOMA-IR. Wyniki: Wysoki poziom glukozy na czczo obserwowano częściej u chorych z zaawansowanym rakiem piersi (24,1%) niż u kobiet z nowotworem we wczesnym stadium zaawansowania (10,6%). W porównaniu z pacjentkami przed menopauzą chore po menopauzie charakteryzowało częstsze występowanie nieprawidłowej glikemii na czczo (21,0% vs 11,1%). Różnice były także istotne dla średniej wartości glukozy na czczo (103,0 ± 1,5 vs 89,0 ± 0,0 mg/dl). W przypadku kobiet po menopauzie wartości te były wyższe u chorych z rakiem piersi, które otrzymały leczenie, w tym chemioterapię (106,5 ± 1,7 mg/dl vs 126,2 ± 1,2 mm Hg), w porównaniu z nowo zdiagnozowanymi pacjentkami, u których nie rozpoczęto jeszcze leczenia w jakiejkolwiek postaci. Wnioski: W grupie badanych chorych cukrzyca była częstym problemem. Chorobę tą częściej obserwowano u kobiet po menopauzie i z zaawansowanym nowotworem. Odnotowano też istotną zależność między cukrzycą a ekspozycją na leczenie raka piersi. Na korelację tę należy zwrócić szczególną uwagę po rozpoznaniu choroby i wdrożeniu leczenia.
Źródło:
Current Gynecologic Oncology; 2017, 15, 4; 231-238
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changing paradigms in breast cancer treatment
Autorzy:
Ali, Shan
Buczek, Dagmara
Jassem, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1196786.pdf
Data publikacji:
2020-12-03
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
breast cancer
sentinel node biopsy
breast-conserving surgery
targeted therapy
molecular profiles
Opis:
In only the past century, the landscape of breast cancer treatment has completely changed. The Halstedian hypothesis of the “contiguous spread” of breast cancer has been replaced by a consideration of its systemic nature. Today, patients with early-stage breast cancer are managed with breast-conserving therapy, which is as effective as mastectomy. Sentinel lymph node biopsy has largely replaced axillary lymph node dissection. Post-operative radiotherapy, chemotherapy and endocrine therapy have increased survival. Pre-operative cytotoxic therapy allows for less extensive surgery and for a curative resection even in more advanced stages. Rapid progress in molecular oncology revealed a large heterogeneity of breast cancer, resulting in a more personalized approach. Targeted therapies directed against epidermal growth factor receptor type 2 (HER2) have improved survival in HER2-positive breast cancer, which was once a poor-prognosis entity. Multi-gene prognostic signatures better predict prognosis and allow many patients to avoid chemotherapy. Personalized treatment has resulted in decreased toxicity and an improved quality of life. Within the past decades, breast cancer has become a good-prognosis malignancy with a five-year survival in the range of 80-85%. Future development of personalized medicine may further refine treatment based on the tumor’s molecular features.
Źródło:
European Journal of Translational and Clinical Medicine; 2020, 3, 2; 53-63
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cancer awareness and socioeconomic status are associated with mammography screening participation and early detection of breast cancer
Autorzy:
Badur, Włodzimierz
Donizy, Piotr
Szełemej, Joanna
Kornafel, Jan
Hałoń, Agnieszka
Matkowski, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/551927.pdf
Data publikacji:
2014
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
breast cancer
oncological awareness
screening
mammography
Źródło:
Family Medicine & Primary Care Review; 2014, 4; 329-332
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of MR relaxation times following trastuzumab treatment of breast cancer cells in a 3D bioreactor
Autorzy:
Bartusik-Aebisher, Dorota
Aebisher, David
Czmil, Anna
Mazur, Damian
Powiązania:
https://bibliotekanauki.pl/articles/895234.pdf
Data publikacji:
2020-02-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
magnetic resonance imaging (MRI)
breast cancer cell cultures
hollow-fiber bioreactor (HFBR)
relaxation time maps
Opis:
The three dimensional tumor environment can be mimicked with the use of cells cultured within a hollow-fiber bioreactor (HFBR). In this work, magnetic resonance imaging (MRI) was used to monitor changes in relaxation time in breast cancer cells following treatment with Trastuzumab in a HFBR system. Breast cancer cells were inoculated into the HFBR system and cultured over a period of 4 weeks. Relaxation time maps were generated according to MRI techniques in three dimensional (3D) cultures of MCF7/Her2 breast cancer and MCF7/Neo4 control cells. MRI measurements showed a variation in values of spin-lattice (T1) and spin-spin (T2) relaxation times related to cell density. Differences in both values (T1 and T2) were noted between untreated cells and cells treated with trastuzumab in the HFBR device. Additionally, 1H MRI was able to provide information about drug penetration in breast cancer cell culture organized in 3D. In conclusion, MRI in vitro can provide direct, noninvasive visualization of cell density in 3D geometry and cell viability as a function of drug uptake. Both T1 and T2 values were higher for lower cell density and accordingly both values, T1 and T2, were lower for higher cell density.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 35-41
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Trastuzumab Efficacy Quantified by Fluorine-19 Magnetic Resonance Imaging
Autorzy:
Bartusik-Aebisher, Dorota
Aebisher, David
Czmil, Mrs Anna
Mazur, Damian
Powiązania:
https://bibliotekanauki.pl/articles/895489.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
trastuzumab
magnetic resonance imaging
breast cancer cells
three-dimensional cell culture
Trastuzumab conjugates
Opis:
The purpose of this study was to conjugate Trastuzumab with fluorine-bearing PAMAM dendrimer to compare activities in three-dimensional (3D) cultured breast cancer cells with parent Trastuzumab. An in vitro study was performed to determine cellular responses to fluorinated Trastuzumab conjugates by Magnetic Resonance Imaging (MRI). Breast cancer cells were cultured in 3D geometry. Proton (1H) MRI and Fluorine-19 (19F) MRI were used for visualization of cellular locations within a Hollow Fiber Bioreactor (HFBR) device and to monitor the cellular response to treatment. The results of this study confirm that cell growth is significantly decreased following treatment with Trastuzumab conjugates. The use of fluorinated Trastuzumab conjugates decreases breast cancer cell growth in 3D cultures and allows for tracking of drug delivery to cancer cells via 19F.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 495-503
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of chemo-induced menopause on the quality of life of young women with non-metastatic breast cancer in Algeria
Autorzy:
Bedhrani, Imene
Nesrine, Sidi Mousa
Mulondo, Samuel
Powiązania:
https://bibliotekanauki.pl/articles/3200748.pdf
Data publikacji:
2023-01-24
Wydawca:
Medical Education
Tematy:
breast cancer
chemo-induced menopause
quality of life
young women
Opis:
Background: Breast cancer is the most common cancer in females worldwide. Young women with breast cancer are treated with chemotherapy, which may exhibit gonadotoxicity thus inducing chemo- induced menopause with a risk of deterioration in their quality of life. Method: A prospective study first of its kind in Algeria was carried out on 57 patients aged between 30 and 49 years that went for consultation at the oncology department of Pierre and Marie Curie Medical Centre Algiers. The medical files obtained and criteria of questionnaires: Quality of Life Questionnaire for Breast Cancer (QLQ-BR23) and the Quality of Life Questionnaire-Core 30 (QLQ-C30) were used to assess the quality of life in patients. Results: From the medical files, patients had a dominant histological type of invasive ductal carcinoma at 96% and Scarff-Bloom-Richardson (SBR) II grade and luminal B profile were the most frequent. The (QLQ-C30) having averages of global health status, symptom score, and functional score with 56.34, 63.7, and 45.75 respectively. QLQ-BR23 having averages for symptom, functional score of 61.6 and 49.71 respectively. Conclusion: Chemotherapy induces gonadotoxicity, which results in chemo-induced menopause that has a negative impact on the quality of life of young women. QLQ-BR23 is more suitable than QLQ-C30 to access the context of this study.
Źródło:
OncoReview; 2022, 12, 4; 69-74
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Badanie ultrasonograficzne piersi – oczekiwania chirurga
Breast ultrasound scans – surgeons’ expectations
Autorzy:
Bednarski, Piotr
Dobruch-Sobczak, Katarzyna
Chrapowicki, Eryk
Jakubowski, Wiesław
Powiązania:
https://bibliotekanauki.pl/articles/1053439.pdf
Data publikacji:
2015
Wydawca:
Medical Communications
Tematy:
breast cancer
breast ultrasound
surgical treatment
usg piersi
leczenie chirurgiczne
rak piersi
Opis:
Recent years have witnessed a dynamic development of mammary gland imaging techniques, particularly ultrasonography and magnetic resonance imaging. A challenge related to these studies is the increase in the precision of the anatomical assessment of breast, particularly for early detection of subclinical lesions, performance of ultrasound- guided biopsy procedures, and accurate preoperative location of pathological lesions so as to optimize the surgical treatment. Ultrasound imaging is a primary and baseline diagnostic procedure the patient with suspected pathological lesions within breast is referred to by the surgeon. Lesions visualized in ultrasound scans are classified according to the BI-RADS US assessment categories. The successive categories (2 through 6) encompass individual pathological lesions, estimating the risk of malignancy and provide guidelines for further diagnostic and therapeutic management. This article described the important aspects of ultrasonographic imaging of focal lesions within the breasts as significant from the standpoint of surgical treatment of patients falling within BI-RADS US categories 3, 4, 5, and 6. Attention is drawn to the importance of ultrasound scans in the assessment of axillary fossa lymph nodes before the decision regarding the surgical treatment.
W ostatnich latach obserwujemy dynamiczny rozwój metod obrazowania gruczołów piersiowych, zwłaszcza ultrasonografii i badania techniką rezonansu magnetycznego. Wyzwaniem dla tych badań pozostaje jeszcze bardziej precyzyjna ocena anatomii piersi, zwłaszcza pod kątem wczesnego wykrywania zmian subklinicznych, monitorowanie zabiegów biopsyjnych pod kontrolą obrazu ultrasonograficznego, dokładna lokalizacja przedoperacyjna nieprawidłowych zmian w celu optymalizacji leczenia chirurgicznego. Badanie ultrasonograficzne jest podstawowym i wyjściowym badaniem diagnostycznym, na które chirurg kieruje pacjentkę z podejrzeniem zmian patologicznych w piersiach. Uwidocznione w tym badaniu zmiany są na podstawie cech morfologicznych przydzielane do konkretnej kategorii wg klasyfikacji BIRADS-usg. Kolejne stopnie tej klasyfikacji (od 2 do 6) obejmują poszczególne nieprawidłowe zmiany (patologie piersi), szacują ryzyko ich złośliwości i zawierają wskazówki dotyczące dalszego postępowania diagnostyczno-terapeutycznego. W artykule omówiono ważne elementy obrazowania ultrasonograficznego zmian ogniskowych w piersiach, istotne z punktu widzenia leczenia chirurgicznego w poszczególnych kategoriach BIRADS-usg 3, 4, 5 i 6. Zwrócono uwagę na znaczenie badania ultrasonograficznego w ocenie węzłów dołów pachowych przed decyzją dotyczącą leczenia chirurgicznego.
Źródło:
Journal of Ultrasonography; 2015, 15, 61; 164-171
2451-070X
Pojawia się w:
Journal of Ultrasonography
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Seksualność i jakość życia kobiet badanych do 18 miesięcy i 5 lat po zabiegu mastektomii – analiza porównawcza.
The sexuality and the quality of life of women examined to 18 months and 5 years after the surgery on the mastectomy – comparative analysis.
Autorzy:
Białek, Katarzyna
Bolek, Katarzyna
Kowalczyk, Robert
Lew-Starowicz, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/527906.pdf
Data publikacji:
2015
Wydawca:
Krakowska Akademia im. Andrzeja Frycza Modrzewskiego
Tematy:
the breast cancer
the sexuality
the quality of life
mastectomy
Opis:
Aim. The aim of the study was to analyze the impact of the disease (breast cancer) and treatment on sexuality patients after mastectomy as part of the project „Sexuality women after mastectomy,” N N404 165640. Materials and methods. Examined were 120 women, firstly 18 months and then again 5 years after radical mastectomy. To investigate their sexual satisfaction and quality of life, self-prepared surveys and standardized questionnaires such as HADS, SQoL-F, QLQBR23 and QLQ-C30 were used. Results. On the basis of these studies it has been shown that breast cancer affects the sexuality and the quality of life of women both 18 months and five years after radical mastectomy. The sexuality of women 18 months after the surgery has been defined as less severe than that in the case of women five years after the surgery. Both groups of women agreed that the most important aspect to them is the emotional contact. A similar level of perceived anxiety and depression have been found among the respondents.
Źródło:
Państwo i Społeczeństwo; 2015, 4; 121-129
1643-8299
2451-0858
Pojawia się w:
Państwo i Społeczeństwo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current and potential oncomarkers in diagnosing breast cancer
Obecnie używane i potencjalne markery nowotworowe w diagnostyce raka piersi
Autorzy:
Bilecová-Rabajdová, M.
Urban, P.
Grešová, A.
Varga, J.
Gregová, K.
Stupák, M.
Mareková, M.
Powiązania:
https://bibliotekanauki.pl/articles/271594.pdf
Data publikacji:
2012
Wydawca:
Górnośląska Wyższa Szkoła Pedagogiczna im. Kardynała Augusta Hlonda
Tematy:
rak piersi
diagnostyka
markery molekularne
markery nowotworowe TVMs
breast cancer
diagnostics
molecular markers
tumour vascular markers
Opis:
Breast cancer is a very serious disease from both an economical and social point of view, because of its high incidence and mortality, as well as its prevalence. Genetic and epigenetic changes as well as the resultant deregulation of mechanisms that affect cellular processes are reflected in the final stage, like significant variability in phenotype. These changes have multiple factors in clinical, morphological but also molecular terms, and they greatly affect the possibility of accurate diagnosis of breast cancer in its early stages. Since no combination of clinical examination, mammography and ultrasonography together with CT and MRI can achieve 100% sensitivity, clinical practice is supported with diagnostic methods based on the monitoring of tumour markers with the emphasis on molecular markers. This review describes the most common molecular markers already used for earlier clinical diagnostics and also proposes new possible markers from the tumour vascular markers group. Any new oncomarkers to improve diagnostic sensitivity and specificity will be of great benefit, and in clinical practice, they may provide an opportunity for early diagnostic and therapeutic intervention, and subsequently better prognosis for the patient as well.
Rak piersi jest bardzo poważną chorobą, zarówno z punktu widzenia ekonomicznego jak i społecznego, ze względu na dużą zachorowalność i umieralność, a także na zakres jego występowania. Zmiany genetyczne i epigenetyczne, jak również wynikająca z nich deregulacja mechanizmów, które wpływają na procesy komórkowe są odzwierciedlone w ostatnim stadium choroby, jak znaczna zmienność fenotypu. Zmiany te mają wiele przyczyn z punktu widzenia klinicznego, morfologicznego, ale również molekularnego oraz znacznie wpływają na możliwość dokładnego rozpoznania raka piersi w jego wczesnych fazach. Ponieważ żadna kombinacja badań klinicznych, mammografii i USG wraz z tomografią komputerową i obrazowaniem magnetyczno-rezonansowym nie może osiągnąć 100% czułości, praktyka kliniczna jest wspierana metodami diagnostycznymi opartymi na monitoringu markerów nowotworowych, ze szczególnym uwzględnieniem markerów molekularnych. Niniejsza recenzja opisuje najbardziej typowe markery molekularne wykorzystywane we wczesnej diagnostyce klinicznej, a także proponuje nowe potencjalne markery z grupy markerów nowotworowych TVMs . Wszelkie nowe markery nowotworowe poprawiające czułość i dokładność diagnostyki będą bardzo pomocne, a w praktyce klinicznej mogą pozwolić na wczesną diagnostykę i leczenie, co polepszy także rokowania pacjenta.
Źródło:
Journal of Ecology and Health; 2012, R. 16, nr 3, 3; 138-143
2082-2634
Pojawia się w:
Journal of Ecology and Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the G/C polymorphism in the 5-untranslated region of the RAD51 gene in breast cancer.
Autorzy:
Blasiak, Janusz
Przybyłowska, Karolina
Czechowska, Agnieszka
Zadrożny, Marek
Pertyński, Tomasz
Rykała, Jan
Kołacińska, Agnieszka
Morawiec, Zbigniew
Drzewoski, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1043672.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
genetic polymorphism
RAD51 gene
RFLP-PCR
breast cancer
Opis:
The breast cancer suppressor proteins BRCA1 and BRCA2 interact with RAD51, a protein essential for maintaining genomic stability by playing a central role in homology-dependent recombinational repair of the DNA double-strand breaks. Therefore, genetic variability in the RAD51 gene may contribute to the appearance and/or progression of breast cancer. A single nucleotide polymorphism in the 5'- untranslated region of RAD51 (a G to C substitution at position 135, the G/C polymorphism) is reported to modulate breast cancer risk. We investigated the distribution of genotypes and frequency of alleles of the G/C polymorphism in breast cancer. Tumor tissues were obtained from postmenopausal women with node-negative and node-positive breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The G/C polymorphism was determined by PCR-based MvaI restriction fragment length polymorphism. The distribution of the genotypes of the G/C polymorphism did not differ significantly (P >0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distribution and allele frequencies between node-positive and node-negative patients. There were no significant differences between distributions of the genotypes in subgroups assigned to histological grades according to Scarf-Bloom-Richardson criteria and the distribution predicted by Hardy-Weinberg equilibrium (P >0.05). Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer and so it may not be useful as an independent marker in this disease.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 249-253
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is not associated with breast cancer.
Autorzy:
Błasiak, Janusz
Smolarz, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1044431.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
gene polymorphism
PAI-1 gene
prognostic marker
plasminogen activator inhibitor-1 (PAI-1)
breast cancer
Opis:
The antigen content of plasminogen activator inhibitor-1 (PAI-1) in primary breast cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumors predict poor prognosis for patients. The gene encoding PAI-1 is highly polymorphic and an insertion (5G)/deletion (4G) polymorphism in the PAI-1 gene promoter (the 4G/5G polymorphism), may have functional significance in PAI-1 expression. In the present work the distribution of genotypes and frequency of alleles of the 4G/5G polymorphism in subjects with breast cancer were investigated. Tumor tissues were obtained from 100 postmenopausal women with node-negative and node-positive ductal breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The 4G/5G polymorphism was determined by PCR amplification using the allele specific primers. The distribution of the genotypes of the 4G/5G polymorphism in both control and patients did not differ significantly (P > 0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distributions and allele frequencies between node-positive and node-negative patients. The 4G/5G polymorphism may not be linked with elevated level of PAI-1 observed in breast cancer and therefore may not be associated with appearance and/or progression of breast cancer.
Źródło:
Acta Biochimica Polonica; 2000, 47, 1; 191-199
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of circulating tumour cells in the breast cancer using CytoTrack system
Autorzy:
Bogacz, A.
Wolek, M.
Górska, A.
Leporowska, E.
Procyk, D.
Kolenda, P.
Litwiniuk, M.
Uzar, I.
Gryszczyńska, A.
Łowicki, Z.
Czerny, B.
Powiązania:
https://bibliotekanauki.pl/articles/2048955.pdf
Data publikacji:
2019
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
circulating tumour cells
breast cancer
CytoTrack CT11
liquid biopsy
wolnokrążące komórki nowotworowe
rak piersi
CytroTrack CT11
płynna biopsja
Opis:
Introduction: Plants are a rich source of healing substances. Cancer is a leading cause of death worldwide while breast cancer is the most common cancer among women. Circulating tumour cells (CTCs) are potential founder cells for metastasis. Therefore, their assessment may be used for monitoring of treatment as well as detecting cancer metastatis. Hence, it is suggested that the number of CTCs may be a valuable tumour biomarker during therapy. Objective: The purpose of this study was to detect CTCs in breast cancer and to validate the method of assessment of CTC count using CytoTrack CT11 technology. Methods: MCF-7 cells were sorted by a FACSARIA flow cytometer from blood samples derived from patients who have not been diagnosed with cancer. Identification and quantitative assessment of MCF-7 cells in blood samples were determined by flow sorting. Then, blood samples containing MCF-7 cells or without MCF-7 were scanned with the use of an automated fluorescence scanning microscope. Results: In in vitro model analysing the glass CytoDisc™ with stained MCF-7 cells, we noted the correlation between the amount of observed tumour cells and expected number of tumour cells. Moreover, coefficient of variation in case of the recovery rate of the assumed number of MCF-7 cells was 30%, 17%, 18% and 15%, respectively. Conclusion: Our study suggest that CTCs could be predictive factor in patients with metastatic cancer especially in breast cancer.
Źródło:
Herba Polonica; 2019, 65, 4; 31-36
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 237

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