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Tytuł:
Buttressing hepaticojejunostomys with hepatic round ligament flap may be beneficial
Autorzy:
Banerjee, Jayant Kumar
Bharathi, Ramanathan Saranga
Rao, Pankaj Purushotam
Powiązania:
https://bibliotekanauki.pl/articles/1393023.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
hepatic round ligament/ ligamentum teres hepatis
Bilioenteric anastomosis
Hepaticojejunostomy
Bile leak
Anastomotic stricture
Autologous hepatic round ligament flap
Opis:
Background: Bile leaks and anastomotic strictures are important complications of hepaticojejunostomy (HJ). Evidence suggests that the use of hepatic round ligament (HRL) to buttress HJ may be beneficial. This study evaluates the feasibility of this approach. Methods: HJs performed over 2 years (Jun 2014- May 2016), with HRL reinforcement, were analyzed. Operative outcomes measured included technical difficulty, blood loss, time necessary for flap harvest, and reinforcement of HJ. The postoperative outcomes measured were the presence of bile leak and anastomotic stricture. Results: Forty-one patients (27 M: 14 F), aged 2-79 years, median age of61 years, underwent HJ with HRL buttress; 27 for periampullary/ head of the pancreas carcinoma; 4 for choledochal cysts; 4 for chronic pancreatitis; 3 for gallbladder carcinoma; 3 for benign biliary stricture. The time for harvesting HRL flaps and buttressing HJ was <10 minutes. No blood was lost during harvesting the flaps. One patient (2.5 %) had grade A leak following radical cholecystectomy, and structures were not observed during a median follow-up of 18 months (6 months to 2years). Conclusion: HRL-based buttressing of HJ can reduce the bile leak and/or stricture rate.
Źródło:
Polish Journal of Surgery; 2017, 89, 4; 5-10
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Iatrogenic Bile Duct Injury. A Significant Surgical Problem. Assessment of Treatment Outcomes in the Departments Own Material
Autorzy:
Bobkiewicz, Adam
Krokowicz, łukasz
Banasiewicz, Tomasz
Kościński, Tomasz
Borejsza-Wysocki, Maciej
Ledwosiński, Witold
Drews, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1396002.pdf
Data publikacji:
2015-03-01
Wydawca:
Index Copernicus International
Tematy:
iatrogenic bile duct injuries
cholecystectomy
complications
Opis:
Iatrogenic bile duct injuries (BDI) are still a challenging diagnostic and therapeutic problem. With the introduction of the laparoscopic technique for the treatment of cholecystolithiasis, the incidence of iatrogenic BDI increased. The aim of the study was a retrospective analysis of 69 patients treated at the department due to iatrogenic BDI in the years 2004-2014. Material and methods. In this paper, we presented the results of a retrospective analysis of 69 patients treated at the Department due to iatrogenic BDI in the years 2004-2014. The data were analysed in terms of age, sex, type of biliary injury, clinical symptoms, the type of repair surgery, the time between the primary surgery and the BDI management, postoperative complications and duration of hospital stay. Results. 82.6% of BDI occurred during laparoscopic cholecystectomy, 8.7% occurred during open cholecystectomy, whereas 6 cases of BDI resulted from surgeries conducted for other indications. In order to assess the degree of BDI, Bismuth and Neuhaus classifications were used (for open and laparoscopic cholecystectomy respectively). 84.1% of patients with confirmed BDI, were transferred to the Department from other hospitals. The average time between the primary surgery and reoperation was 6.2 days (SD 4). The most common clinical symptom was biliary fistula observed in 78.3% of patients. In 28 patients, unsuccessful attempts to manage BDI were made prior to the admission to the Department in other centres. The repair procedure was mainly conducted by laparotomy (82.6%) and by the endoscopic approach (15.9%). Hepaticojejunostomy was the most common type of reconstruction following BDI (34.7%). Conclusions. The increase in the rate of iatrogenic bile duct injury remains a challenging surgical problem. The management of BDI should be multidisciplinary treatment. Referring patients with both suspected and confirmed iatrogenic BDI to tertiary centres allows more effective treatment to be implemented.
Źródło:
Polish Journal of Surgery; 2014, 86, 12; 576-583
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Iatrogenic bile duct injuries – clinical problems
Autorzy:
Głuszek, Stanisław
Kot, Marta
Bałchanowski, Norbert
Matykiewicz, Jarosław
Kuchinka, Jakub
Kozieł, Dorota
Wawrzycka, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1395690.pdf
Data publikacji:
2014-01-01
Wydawca:
Index Copernicus International
Tematy:
laparoscopic surgery
cholecystectomy
iatrogenic bile duct injury
Opis:
Laparoscopic cholecystectomy is one of the most frequently performed surgical procedures in surgical wards. Iatrogenic bile duct injuries (IBDI) incurred during the procedures are among postoperative complications that are most difficult to treat. The risk of bile duct injury is 0.2-0.4%, and their consequences are unpleasant both for the surgeon and for the patient. The aim of the study was analysis of iatrogenic bile duct injuries and methods of their repair,taking into consideration the circumstances, under which the injuries occur. Material and methods. The study group consisted of 16 patients who had suffered IBDI during surgery. The analysed parameters included sex, age, indications for surgery, the setting of the surgical procedure and the type of bile duct injury. Additionally, the time of injury diagnosis, type of repair and treatment outcome were assessed. The IBDI analysis used the EAES classification of injuries. The time of IBDI repair was defined as immediate, early or late,depending on the time that had passed from the injury. The analysis included complications seen after bile duct repair. Results. The study group consisted of 10 women and 6 men, aged 29-84. Patients underwent 6 classic cholecystectomies, 8 laparoscopic cholecystectomies, one gastrotomy to remove oesophageal prosthesis and one laparotomy due to peptic ulcer. IBDI was diagnosed intraoperatively in 4 patients. In 12 patients IBDI was diagnosed within 1-7 days. The diagnosis was based on endoscopic retrograde cholangiopancreatography and the results of biochemistry tests. According to the EAES classification, the injuries were of type 1 (4 patients), type 2 (8 patients), type 5 (3 patients) and type 6 (1 patients). Reconstruction procedures were performed during the same anaesthesia session in 3 patients, and in the early period in 13 patients. The main procedure was Roux-en-Y anastomosis (12 patients), with the remaining including bile-duct suturing over a T-tube (3 patients) and underpinning of an accessory bile duct in the pocket left after gallbladder removal (1 patient). The most common reconstruction complications included bile leak (3 patients), recurrent cholangitis (3 patients) and bile duct stricture (2 patients). Mortality in the study group was 12.5%. Conclusions. The procedures of laparoscopic and classic cholecystectomy are associated with a risk of IBDI, especially in the presence of inflammatory state of the gall-bladder. IBDI is a complex complication: its treatment poses a challenge for the operating surgeon, and even the most careful treatment adversely affects the patient’s lifedue to complications.
Źródło:
Polish Journal of Surgery; 2014, 86, 1; 17-25
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wrodzony brak pęcherzyka żółciowego u psów
Gallbladder agenesis in the dog
Autorzy:
Gójska-Zygner, Olga
Galanty, Marek
Degórska, Beata
Frymus, Jan
Ziółek, Magdalena
Gajger, Joanna
Andrzejewska-Siwak, Anna
Powiązania:
https://bibliotekanauki.pl/articles/22180997.pdf
Data publikacji:
2021
Wydawca:
Krajowa Izba Lekarsko-Weterynaryjna
Tematy:
psy
zaburzenia rozwojowe
cholestaza
kwas ursodeoksycholowy
objawy kliniczne
rozpoznanie
leczenie
zwierzęta towarzyszące
kwasy żółciowe
wrodzony brak pęcherzyka żółciowego
bile acids
cholestasis
dog
gallbladder agenesis
ursodeoxycholic acid
Opis:
Gallbladder agenesis is an extremely rare, developmental disorder observed in humans and dogs. It seems probable that the disease may lead to cholestasis in affected dogs. In this review article, the authors proposed pathogenesis of liver changes in dogs with gallbladder agenesis and discussed the therapy with ursodeoxycholic acid (UDCA), a secondary bile acid, used in treatment or prevention of the liver and bile tract diseases.
Źródło:
Życie Weterynaryjne; 2021, 96, 09; 660-666
0137-6810
Pojawia się w:
Życie Weterynaryjne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola 7α- hydroksylazy cholesterolu i genu CYP7A1 w fizjologii i patologii człowieka
Role of the cholesterol 7α- hydroxylase and CYP7A1 gene in human physiology and pathology
Autorzy:
Iwanicki, Tomasz
Balcerzyk, Anna
Żak, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1039371.pdf
Data publikacji:
2010
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
cyp7a1
kwasy żółciowe
cholesterol
polimorfizm
polymorphism
bile acids
Opis:
Cholesterol 7α- hydroxylase (CYP7A1) belongs to the big family of cytochrome p450. Biological significance of cholesterol 7α- hydroxylase is associated with beginning of cholesterol transformation to the bile acids. CYP7A1 affinity to the cholesterol is determined by its unique protein structure, different from the other proteins of cytochrome p450 family. CYP7A1 enzyme is enoded by CYP7A1 gene localized in short arm of chromosome 8. Expression of CYP7A1 gene could be regulated by farnesoid X receptor (FXR) or by kinases, which modulate nuclear receptor`s binding abilities to the gene promoter. Polymorphic variants and mutations present in the promoter region impact on the quality properties of the enzyme. CYP7A1 gene, encoding key enzyme of the cholesterol catabolic pathway is a main candidate to the research of its association with changes of serum lipids levels. Presence of genetic variants can be associated with changed levels of total cholesterol, triglycerides and Low- density lipoproteins (LDL). Promoter polymorphism of CYP7A1 is also main candidate for the research of association with such disease entities as gallbladder stone formation, colon cancer, gallbladder cancer or atherogenic- based diseases.
7α- hydroksylaza cholesterolu (CYP7A1) jest enzymem należącym do dużej rodziny cytochromu p450. Znaczenie biologiczne 7α- hydroksylazy cholesterolu związane jest z rozpoczęciem szeregu przemian cholesterolu do kwasów żółciowych. Powinowactwo CYP7A1 do cholesterolu determinowane jest unikalną budową białka, odmienną od reszty białek rodziny cytochromu p450. Enzym ten kodowany jest przez gen CYP7A1, którego locus znajduje się na ramieniu krótkim chromosomu ósmego. Ekspresja tego genu może być regulowana przy udziale farnezylowego receptora X (FXR), bądź zachodzić poprzez szereg kinaz białkowych, modulujących zdolność przyłączania się swoistych receptorów jądrowych do promotora CYP7A1. Warianty polimorficzne i mutacje, występujące w regionie promotorowym, wpływają na właściwości jakościowe enzymu. Gen CYP7A1, kodując kluczowy enzym w katabolizmie cholesterolu, jest głównym kandydatem do badań jego związku ze zmianami w osoczowym poziomie lipoprotein. Obecność wariantów genetycznych w promotorze genu CYP7A1 może być związana ze zmienionym poziomem cholesterolu całkowitego, triacylogliceroli czy LDL (Low- Density Lipoprotein). Polimorfizm promotora genu kodującego kluczowy enzym szlaku syntezy kwasów żółciowych i usuwania cholesterolu z organizmu jest głównym kandydatem do badań asocjacyjnych z takimi jednostkami chorobowymi, jak kamica żółciowa, nowotwory jelita grubego i woreczka żółciowego czy choroby o podłożu miażdżycowym.
Źródło:
Annales Academiae Medicae Silesiensis; 2010, 64, 3-4; 48-57
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reduction of bilirubin ditaurate by the intestinal bacterium Clostridium perfringens
Autorzy:
Koníčková, Renata
Jirásková, Alena
Zelenka, Jaroslav
Lešetický, Ladislav
Štícha, Martin
Vítek, Libor
Powiązania:
https://bibliotekanauki.pl/articles/1039751.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bilirubin ditaurate
bile pigments
urobilinoids
intestinal metabolism
Clostridium perfringens
Opis:
Bilirubin is degraded in the human gut by microflora into urobilinoids. In our study we investigated whether the bilirubin-reducing strain of Clostridium perfringens can reduce bilirubin ditaurate (BDT), a bile pigment of some lower vertebrates, without hydrolysis of the taurine moiety. C. perfringes was incubated under anaerobic conditions with BDT; reduction products were quantified by spectrophotometry and separated by TLC. Based on Rf values of BDT reduction products and synthetic urobilinogen ditaurate, three novel taurine-conjugated urobilinoids were identified. It is likely that bilirubin-reducing enzyme(s) serve for the effective disposal of electrons produced by fermentolytic processes in these anaerobic bacteria.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 289-292
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Micellar electrokinetic chromatography with bile salts for separation of flavanone diastereomers
Autorzy:
Kowalczyk, M.
Asztemborska, M.
Powiązania:
https://bibliotekanauki.pl/articles/92310.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Przyrodniczo-Humanistyczny w Siedlcach
Tematy:
bile salts
diastereomers separation
flavanone glycosides
MEKC
binding constants
sole żółciowe
rozdzielanie diastereomerów
glikozydy flawanonów
stałe trwałości
Opis:
Sodium cholate and sodium deoxycholate were applied in the micellar electrokinetic chromatography technique as separating agents for the diastereomers of flavanone glycosides. The effects of the organic solvent buffer modifier, bile salt type and concentration were evaluated for enhancing distereomer separation. The critical micelle concentration of sodium cholate and sodium deoxycholate in the applied running buffer was determined. The bi nding constants of flavanone glycosides to bile salts micelle were estimated. The elaborated analytical method was used to analyse the flavanone fraction of bitter orange (Citrus aurantium) and grapefruit (Citrus paradisi) juice.
Cholan sodu i deoksycholan sodu zostały zastosowane w technice micelarnej elektrokinetycznej chromatografii cieczowej jako czynnik rozdzielający diastereomery glikozydów flawanonów. Oceniono wpływ rozpuszczalnika organicznego jako modyfikatora buforu, typu soli żółciowej oraz jej stężenia na wzmocnienie rozdzielenia diastereomerów. Wyznaczono krytyczne stężenie micelarne cholanu sodu i deoksycholanu sodu w zastosowanym buforze rozdzielającym. Oszacowano stałe trwałości glikozydów flawanonów z micelami soli żółciowych. Opracowana metoda została wykorzystana do analizy frakcji flawanonowej w soku gorzkiej pomarańczy (Citrus aurantium) i grejfruta (Citrus paradise).
Źródło:
Camera Separatoria; 2016, 8, 1; 45-54
2083-6392
2299-6265
Pojawia się w:
Camera Separatoria
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reprinted with permission of editor-in-chief of Annals of Surgery: Annals of Surgery: Vol. 266, nr 5, November 2017; 703 - 705: Modern Surgeons: Still Masters of Their Trade or Just Operators of Medical Equipment?
Autorzy:
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1392874.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
vascular surgery
cholecystectomy
ultrasonography
bile ducts
liver transplantation
pancreas
laparoscopy
Opis:
My surgical education began at a time when Poland formed part of the communist bloc and was isolated from the world, or in today’s Terms – it remained behind the Iron Curtain. This was true of all areas of life, including medicine. When after 40 years of work, I look back at my professional career; I wonder whether I owe my proficiency in surgery to my experience and dexterity or, like many others, to technological progress. Two of the great Polish surgeons were my mentors and teachers. Professor Zdzisław Łapiński was the one I met first. He was a manual genius and an unusual operational strategist. Granted, he had one character defect, but nobody’s perfect after all. In 1975, I defended my dissertation. I was convinced that I should continue my education at a center abroad, preferably within a postdoctoral scholarship. Professor Łapiński wanted me to learn everything about surgery from him. I decided otherwise, and in 1978 with his tacit agreement, I obtained a Humboldt Fellowship and went to Heidelberg, to the department headed by none other than Professor Fritz Linder.1 I started my research for the habilitation thesis at the Experimentelle Chirurgie Abteilung of his Department.
Źródło:
Polish Journal of Surgery; 2018, 90, 2; 1-4
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modelling of the pathological bile flow in the duct with a calculus
Autorzy:
Kuchumov, A. G.
Nyashin, Y. I.
Samarcev, V. A.
Gavrilov, V. A.
Powiązania:
https://bibliotekanauki.pl/articles/307046.pdf
Data publikacji:
2013
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
biliary system
bile flow
non-Newtonian fluid
Vater’s papilla
przepływ żółci
płyn nienewtonowski
Opis:
The aim of the present paper is to develop an analytical model for description of the pathological bile flow in the major duodenal papilla duct with a calculus. The problem is separated into two parts. The first part deals with determination of bile behaviour and constitutive relation parameters of the pathological bile. The viscosity vs. shear rate, the viscosity vs. time, and shear stress vs. shear rate dependences are obtained for different types of bile taken from patients of different age and sex. As a result, the approximation of curves described by the Casson equation was obtained. It was shown that the pathological bile is a thixotropic non-Newtonian fluid. The second part is directly related to modelling of the bile flow in the duct with a calculus. As a result of solving the problem, the bile velocity profile, flow rate vs. time, and bile pressure vs. calculus radius were obtained. The dependences obtained may play an important role in the assessment of an indication to operation.
Źródło:
Acta of Bioengineering and Biomechanics; 2013, 15, 4; 9-17
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cholelithiasis – always infected?
Autorzy:
Matyjas, Tomasz
Pomorski, Lech
Witas, Henryk
Płoszaj, Tomasz
Matyjas, Katarzyna
Kaczka, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1393554.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
bile
bile deposits
gallstones
biliary infection
bacteria
Opis:
This study aims to present results regarding the presence and identification of bacterial strains found in bile and gallstones located in the gallbladder and bile ducts in patients operated on due to cholelithiasis. Materials and Methods. Bacterial culture was evaluated in 92 patients. There were 54 women (59%) and 38 men (41%) who underwent surgery on account of cholelithiasis and /or gallstones in bile ducts between 2013 and 2014. Bile and gallstone samples were cultured intraoperatively for bacteria; bacterial strains were identified, and their sensitivity to antibiotics was determined. Molecular methods (NGS and Sanger method) were used to separate bacterial strains in one of the gallbladder stones and the results were compared with bacterial strains grown from the bile. Results. Bile cultures were positive in 46 patients that is, 50% of the study group. The following bacteria strains were grown: Enterococcus spp. (44%), Escherichia coli (37%) and Klebsiella spp. (35%). Candidiasis accompanied by bacterial infection was detected in 7 patients (15%). Molecular testing of gallstones revealed DNA of Enterococcus spp., Escherichia spp., Streptococcus spp. and Clostridium spp. In the bile culture of the same patient Enterococcus spp. (avium and faecalis) was detected. Conclusion 1. More than one pathogen was grown on samples obtained from 31 patients (70%) with bile infection. 2. The most common pathogens include Enterococcus spp., Escherichia coli and Klebsiella spp. 3. Bacterial infections are often accompanied by a fungal infection (Candida albicans) 4. Bacterial strains grown from a gallstone sample partially corresponded with strains identified in the bile of the same patient.
Źródło:
Polish Journal of Surgery; 2017, 89, 3; 23-26
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation on adsorption of fatty and bile acids in the presence of dietary supplements containing chromium
Badanie sorpcji kwasow tluszczowych i cholowych w obecnosci suplementow diety zawierajacych chrom
Autorzy:
Meler, J
Grimling, B.
Pluta, J.
Powiązania:
https://bibliotekanauki.pl/articles/14261.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
adsorption
fatty acid
bile acid
dietary supplement
chromium
chitosan
bioavailability
in vitro model
macroelement
microelement
Opis:
Dietary supplements contain not only macro- and microelements, but also elements which affect human metabolism. Many products available on the market contain chromium compounds together with chitosan used as a dietary supplement enhancing the digestion of lipids. The studies involved natural chitosan from krill available on the market, with the deacetylation degree of 85 to 95%, and dietary supplements containing chitosan (Vitana®, Hitec Nutrition®) as well as a product containing ionic chromium with niacin and several aminoacids — Chromdiet®). The study has determined the capability of binding fatty and bile acids by dietary supplements containing chitosan and chromium. The process of lipids and bile acids adsorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions. The findings prove that extracts of fatty acids and bile acids undergo adsorption by various kinds of adjuvant substances found in dietary supplements, which confirms a significant effect of these polymers on the bioavailability of fatty and bile acids in a human organism. The addition of chromium to a supplement does not effect the capability of chitosan to bind fatty and bile acids. Mean adsorption of bile acids by 1 g of the polymer (chitosan, inulin, fibre) ranges from 0.9 g to 1.79 g depending on the pH (which decreases the bioavailability of lipids by 15-30%).
Suplementy diety to nie tylko makro- i mikroelementy, ale tez pierwiastki, które wykazują wpływ na przemiany metaboliczne organizmu. Obecnie na rynku jest sporo preparatów zawierających związki chromu wraz z chitozanem stosowanych jako dodatek żywieniowy wspomagający trawienie tłuszczowców. W pracy przebadano naturalny chitozan z kryla o stopniu deacetylacji od 85 do 95% występujący obecnie w sprzedaży rynkowej oraz preparaty zawierające chitozany, stosowane jako suplementy diety (Vitana®, Hitec Nutrition® oraz preparat zawierający chrom—Chromdiet®). Określono zdolności wiązania tłuszczowców i kwasów żółciowych przez suplementy diety zawierające chrom i chitozan. Zjawisko adsorpcji lipidów i kwasów żółciowych badano metodą dynamiczną w modelu biofarmaceutycznym imitującym warunki in vitro. Otrzymane wyniki dowodzą, że kwasy tłuszczowe i ekstrakty kwasów żółciowych ulegają adsorpcji przez różnego rodzaju substancje pomocnicze służące do wytworzenia suplementu diety, co potwierdza znaczący wpływ tych polimerów na biodostępnośc kwasów tłuszczowych i żółciowych w organizmie człowieka. Średnia wielkość adsorpcji kwasów żółciowych przez 1 g polimeru w zależności od pH środowiska mieściła się w granicach od 0,90 g do 1,79 g (daje to zmniejszenie biodostępności tłuszczowców o 15-30%).
Źródło:
Journal of Elementology; 2010, 15, 1; 141-147
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of Unithiol on the Liver in the Conditions of a Mechanical Injury Against the Background of Poisoning by Zinc and Copper Salts
Wpływ unithiolu na wątrobę w warunkach urazu mechanicznego na tle zatrucia solami cynku i miedzi
Autorzy:
Melnyk, Nataliia
Fedoriv, Olha
Kopach, Oleksandra
Powiązania:
https://bibliotekanauki.pl/articles/2159217.pdf
Data publikacji:
2022-12-30
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
Unithiol
zinc sulfate
copper sulfate
bile acids
injury
wounds
siarczan cynku
siarczan miedzi
kwasy żółciowe
uraz
rany
Opis:
Background. The aim of the study was to find out the influence of excess copper and zinc ions in drinking water on the bile-forming and bile-secreting functions of the liver in the conditions of mechanical trauma and the effectiveness of the antidote therapy. Material and methods. The experiments were performed on 60 Wistar strain male rats weighing 180-200 g. There were 3 groups of experimental animals in the experiment: 1 group – only skeletal trauma was simulated; 2 group – a skeletal injury was simulated and zinc and copper salts were administered; 3 group – skeletal trauma + zinc and copper salts followed by Unithiol treatment. Results. In the late period of traumatic illness (14-28 days), after a severe skeletal injury, the intensity of bromsulfalein increased in the liver tissue, and there were signs of increased formation of direct bilirubin in terms of additional intake of copper and zinc ions. The animals with severe skeletal trauma were accompanied by a significant deterioration in the functional state of the liver in comparison to the animals with similar skeletal trauma without additional intoxication. Conclusions. Under conditions of additional intake of copper and zinc ions (in the 2nd group), after 14 days and 28 days of observation, all the studied indicators are much higher than in the group of the animals without additional intoxication with these ions. The use of Unithiol reduced the toxic effect of copper and zinc ions on the studied indicators of the functional state of the liver both in the early and late period of the traumatic disease.
Wprowadzenie. Celem pracy było poznanie wpływu nadmiaru jonów miedzi i cynku w wodzie pitnej na funkcje wytwarzania i wydzielania żółci w wątrobie w warunkach urazu mechanicznego oraz skuteczności terapii antidotum. Materiał i metody. Doświadczenia przeprowadzono na 60 samcach szczurów szczepu Wistar o masie 180-200 g. W badaniu uczestniczyły 3 grupy zwierząt doświadczalnych: grupa 1 – symulowano tylko uraz szkieletowy; grupa 2 – symulowano uraz szkieletowy i podawano sole cynku i miedzi; grupa 3 – uraz szkieletowy + sole cynku i miedzi, a następnie leczenie Unithiolem. Wyniki. W późnym okresie choroby urazowej (14-28 dni), po ciężkim urazie szkieletowym, wzrosło nasilenie bromosulfaleiny w tkance wątrobowej i wystąpiły objawy zwiększonego wytwarzania bilirubiny bezpośredniej na skutek dodatkowego przyjmowania jonów miedzi i cynku. Zwierzętom z ciężkim urazem szkieletowym towarzyszyło znaczne pogorszenie stanu czynnościowego wątroby w przeciwieństwie do zwierząt z podobnym urazem szkieletowym bez dodatkowego zatrucia. Wnioski. W warunkach dodatkowego przyjmowania jonów miedzi i cynku (w drugiej grupie), po 14 i 28 dniach obserwacji, wszystkie badane wskaźniki były znacznie wyższe niż w grupie zwierząt bez dodatkowego zatrucia jonami. Stosowanie Unithiolu zmniejszyło toksyczny wpływ jonów miedzi i cynku na badane wskaźniki stanu czynnościowego wątroby zarówno we wczesnym, jak i późnym okresie choroby urazowej.
Źródło:
Health Problems of Civilization; 2022, 16, 4; 323-329
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Interstitial Cajal-Like Cells and Bile Lithogenicity in the Pathogenesis of Gall-Stone Disease
Autorzy:
Pasternak, Artur
Matyja, Andrzej
Gil, Krzysztof
Gajda, Mariusz
Tomaszewski, Krzysztof A.
Matyja, Maciej
Walocha, Jerzy A.
Kulig, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1396274.pdf
Data publikacji:
2013-06-01
Wydawca:
Index Copernicus International
Tematy:
bile lithogenecity
interstitial Cajal-like cells
gall-stone disease
c-Kit
mast cells
Opis:
Gall-stone disease constitutes a serious clinical problem and is the most frequent cause of elective cholecystectomies. There are many etiopatogenic factors however; lithogenic bile and its stasis due to gall-bladder hypomotility seem to be the most important. In recent years discovery of pacemaker function of Interstitial Cells of Cajal changed our understanding of smooth muscle physiology and helped to disclose many gastrointestinal motility disorders. The aim of the study was identification and quantification of interstitial Cajal-like cells (ICLCs) in gall-bladder muscle wall from patients with cholelithiasis and in gall-stone-free controls, as well as determination of the relationship between the number of ICLCs and Cholesterol Saturation Index (CSI) of bile in both analyzed groups. Material and methods. 20 patients operated for symptomatic cholelithiasis were enrolled into the study group. The control group consisted of 20 patients operated for pancreatic head tumors, with no pre- and intraoperative signs of gall-stones. Identification of ICLCs in the gall-bladder was performed by means of double immunofluorescence technique with anti c-Kit and anti-mast cell tryptase antibodies. Quantitative analysis was carried out under fluorescence microscopy conjoined with image analysis software. Bile samples were used for calculation of CSI. Results. ICLCs were detected within gall-bladder muscle wall. Number of ICLCs was statistically significantly lower in patients from the study group as compared to control. The study also revealed statistically significantly higher CSI in the study group. Conclusions. The quantity of ICLCs is diminished in the gall-bladder from patients with cholelithiasis and there is negative correlation between the number of ICLCs and CSI of bile. Regarding the role of ICCs in regulation of GI tract motility, it appears that reduction in their number may be important etiopatogenic factor of cholelithiasis.
Źródło:
Polish Journal of Surgery; 2013, 85, 6; 311-316
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Secretin, cholecystokinin and the biliary canalicular secretion in the rat
Autorzy:
Romanski, K W
Bochenek, W.J.
Unold, J.
Szczepaniak, M.
Powiązania:
https://bibliotekanauki.pl/articles/70531.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
biliary tree
secretin
biliary canalicular secretion
gastrointestinal hormone
gastrointestinal peptide
rat
biliary canalicular flow
cholecystokinin
bile acid
bile
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Postcholecystectomy bile duct injuries: evolution of surgical treatment
Autorzy:
Šileikis, Audrius
Žulpaitė, Rūta
Šileikytė, Auksė
Lukšta, Martynas
Powiązania:
https://bibliotekanauki.pl/articles/1392375.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
Complications
laparoscopic cholecystectomy
bile duct injury
Opis:
Introduction: Bile duct injuries (BDIs) still occur during laparoscopic cholecystectomy. Although management of such complications is challenging, a collaboration of a multidisciplinary team and development of treatment methods and materials often lead to successful treatment. Materials and methods: Medical records of 67 patients who have experienced bile duct injuries after laparoscopic cholecystectomy were retrospectively reviewed. All injuries were classified according to the European Association for Endoscopic Surgery ATOM classification and investigated by the manifestation of the injury, surgical repair technique, early and late complications. Results: In 28 (41.8 %) patients with partial divisions, the surgical treatment of BDI was completed with endoscopic retrograde cholangiopancreatography (ERCP) and stenting while in 14 (20.1%) cases, the defect of bile duct was closed by suture. End-to-end ductal anastomosis was performed for 6 (13.4%) patients with complete division while 19 (28.3%) patients underwent hepaticojejunostomy. We followed up 58 (92.1%) of 63 patients. The mean follow-up duration was 25.7 (3 - 123) months. Twenty-three (39.7%) patients were found to have structures. Discussion: Intraoperative detection and management of BDIs are crucial to achieving good results. The routine intraoperative cholangiography and possibilities of repair by initial surgeons in peripheral hospitals remain controversial. Stenting with a covered self-expanding metal stent is promising for the patients with partial divisions of bile ducts. Initial hepaticojejunostomy is often a preferred treatment for transected bile ducts because of a lower rate of anastomosis strictures. However, an end-to-end anastomosis is more physiological, and endoscopy allows successful management of the strictures, we suggest choosing this treatment when possible Recommendation for paperwork content: Classifying bile duct injuries according to the new ATOM classification may be useful in choosing the most appropriate treatment in each case.
Źródło:
Polish Journal of Surgery; 2019, 91, 1; 14-21
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
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