Temat: bile - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Cholelithiasis – always infected?
Autorzy:: Matyjas, Tomasz
Pomorski, Lech
Witas, Henryk
Płoszaj, Tomasz
Matyjas, Katarzyna
Kaczka, Krzysztof
Powiązania:: https://bibliotekanauki.pl/articles/1393554.pdf
Data publikacji:: 2017
Wydawca:: Index Copernicus International
Tematy:: bile
bile deposits
gallstones
biliary infection
bacteria
Opis:: This study aims to present results regarding the presence and identification of bacterial strains found in bile and gallstones located in the gallbladder and bile ducts in patients operated on due to cholelithiasis. Materials and Methods. Bacterial culture was evaluated in 92 patients. There were 54 women (59%) and 38 men (41%) who underwent surgery on account of cholelithiasis and /or gallstones in bile ducts between 2013 and 2014. Bile and gallstone samples were cultured intraoperatively for bacteria; bacterial strains were identified, and their sensitivity to antibiotics was determined. Molecular methods (NGS and Sanger method) were used to separate bacterial strains in one of the gallbladder stones and the results were compared with bacterial strains grown from the bile. Results. Bile cultures were positive in 46 patients that is, 50% of the study group. The following bacteria strains were grown: Enterococcus spp. (44%), Escherichia coli (37%) and Klebsiella spp. (35%). Candidiasis accompanied by bacterial infection was detected in 7 patients (15%). Molecular testing of gallstones revealed DNA of Enterococcus spp., Escherichia spp., Streptococcus spp. and Clostridium spp. In the bile culture of the same patient Enterococcus spp. (avium and faecalis) was detected. Conclusion 1. More than one pathogen was grown on samples obtained from 31 patients (70%) with bile infection. 2. The most common pathogens include Enterococcus spp., Escherichia coli and Klebsiella spp. 3. Bacterial infections are often accompanied by a fungal infection (Candida albicans) 4. Bacterial strains grown from a gallstone sample partially corresponded with strains identified in the bile of the same patient.
Źródło:: Polish Journal of Surgery; 2017, 89, 3; 23-26
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Postcholecystectomy bile duct injuries: evolution of surgical treatment
Autorzy:: Šileikis, Audrius
Žulpaitė, Rūta
Šileikytė, Auksė
Lukšta, Martynas
Powiązania:: https://bibliotekanauki.pl/articles/1392375.pdf
Data publikacji:: 2019
Wydawca:: Index Copernicus International
Tematy:: Complications
laparoscopic cholecystectomy
bile duct injury
Opis:: Introduction: Bile duct injuries (BDIs) still occur during laparoscopic cholecystectomy. Although management of such complications is challenging, a collaboration of a multidisciplinary team and development of treatment methods and materials often lead to successful treatment. Materials and methods: Medical records of 67 patients who have experienced bile duct injuries after laparoscopic cholecystectomy were retrospectively reviewed. All injuries were classified according to the European Association for Endoscopic Surgery ATOM classification and investigated by the manifestation of the injury, surgical repair technique, early and late complications. Results: In 28 (41.8 %) patients with partial divisions, the surgical treatment of BDI was completed with endoscopic retrograde cholangiopancreatography (ERCP) and stenting while in 14 (20.1%) cases, the defect of bile duct was closed by suture. End-to-end ductal anastomosis was performed for 6 (13.4%) patients with complete division while 19 (28.3%) patients underwent hepaticojejunostomy. We followed up 58 (92.1%) of 63 patients. The mean follow-up duration was 25.7 (3 - 123) months. Twenty-three (39.7%) patients were found to have structures. Discussion: Intraoperative detection and management of BDIs are crucial to achieving good results. The routine intraoperative cholangiography and possibilities of repair by initial surgeons in peripheral hospitals remain controversial. Stenting with a covered self-expanding metal stent is promising for the patients with partial divisions of bile ducts. Initial hepaticojejunostomy is often a preferred treatment for transected bile ducts because of a lower rate of anastomosis strictures. However, an end-to-end anastomosis is more physiological, and endoscopy allows successful management of the strictures, we suggest choosing this treatment when possible Recommendation for paperwork content: Classifying bile duct injuries according to the new ATOM classification may be useful in choosing the most appropriate treatment in each case.
Źródło:: Polish Journal of Surgery; 2019, 91, 1; 14-21
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Is the Age of Patients with Iatrogenic Bile Duct Injuries Increasing?
Autorzy:: Stankiewicz, Rafał
Najnigier, Bogusław
Krawczyk, Marek
Powiązania:: https://bibliotekanauki.pl/articles/1395562.pdf
Data publikacji:: 2015-03-01
Wydawca:: Index Copernicus International
Tematy:: cholecystectomy
complication
iatrogenic bile duct injury
Opis:: Resection of the gall-bladder is still the most common surgical procedure performed at general surgery departments. The laparoscopic method used in the majority of cases offers considerable benefits but at the same time is associated with an increased rate of bile duct complications. So far, a slim female aged 25-50 years was a typical patient with a iatrogenic bile duct injury. The aim of the study was to identify the age of patients with iatrogenic bile duct injuries as well as the clinical course observed in recent years. Material and methods. Gender and age structure of patients admitted to the Department of General, Transplant and Liver Surgery between the beginning of 2011 and June 2014 and treated for iatrogenic bile duct injuries, complications of laparoscopic cholecystectomy, were analysed. The patients were referred to the department as a reference centre. Results. In the group of 186 patients, females predominated (69.4%) and the mean age was 52 years. A considerable increase in the mean age of patients treated in 2014 as compared with previous years was seen. This was related to an increased rate of bile duct injuries in patients aged over 70 years, who accounted for about 25% of the group. In previous years, bile duct injuries in patients of such an advanced age happened considerably less frequently. Conclusions. A iatrogenic bile duct injury in an elderly person may prove a fatal complication. A repair surgery, i.e. the biliary-enteric anastomosis, is a major and burdensome procedure, particularly in the case of patients aged over 70 years. Special caution during laparoscopic cholecystectomy is advised in this population, and the slightest doubts should lead to conversion.
Źródło:: Polish Journal of Surgery; 2015, 87, 3; 129-133
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Iatrogenic Bile Duct Injury. A Significant Surgical Problem. Assessment of Treatment Outcomes in the Departments Own Material
Autorzy:: Bobkiewicz, Adam
Krokowicz, łukasz
Banasiewicz, Tomasz
Kościński, Tomasz
Borejsza-Wysocki, Maciej
Ledwosiński, Witold
Drews, Michał
Powiązania:: https://bibliotekanauki.pl/articles/1396002.pdf
Data publikacji:: 2015-03-01
Wydawca:: Index Copernicus International
Tematy:: iatrogenic bile duct injuries
cholecystectomy
complications
Opis:: Iatrogenic bile duct injuries (BDI) are still a challenging diagnostic and therapeutic problem. With the introduction of the laparoscopic technique for the treatment of cholecystolithiasis, the incidence of iatrogenic BDI increased. The aim of the study was a retrospective analysis of 69 patients treated at the department due to iatrogenic BDI in the years 2004-2014. Material and methods. In this paper, we presented the results of a retrospective analysis of 69 patients treated at the Department due to iatrogenic BDI in the years 2004-2014. The data were analysed in terms of age, sex, type of biliary injury, clinical symptoms, the type of repair surgery, the time between the primary surgery and the BDI management, postoperative complications and duration of hospital stay. Results. 82.6% of BDI occurred during laparoscopic cholecystectomy, 8.7% occurred during open cholecystectomy, whereas 6 cases of BDI resulted from surgeries conducted for other indications. In order to assess the degree of BDI, Bismuth and Neuhaus classifications were used (for open and laparoscopic cholecystectomy respectively). 84.1% of patients with confirmed BDI, were transferred to the Department from other hospitals. The average time between the primary surgery and reoperation was 6.2 days (SD 4). The most common clinical symptom was biliary fistula observed in 78.3% of patients. In 28 patients, unsuccessful attempts to manage BDI were made prior to the admission to the Department in other centres. The repair procedure was mainly conducted by laparotomy (82.6%) and by the endoscopic approach (15.9%). Hepaticojejunostomy was the most common type of reconstruction following BDI (34.7%). Conclusions. The increase in the rate of iatrogenic bile duct injury remains a challenging surgical problem. The management of BDI should be multidisciplinary treatment. Referring patients with both suspected and confirmed iatrogenic BDI to tertiary centres allows more effective treatment to be implemented.
Źródło:: Polish Journal of Surgery; 2014, 86, 12; 576-583
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Iatrogenic bile duct injuries – clinical problems
Autorzy:: Głuszek, Stanisław
Kot, Marta
Bałchanowski, Norbert
Matykiewicz, Jarosław
Kuchinka, Jakub
Kozieł, Dorota
Wawrzycka, Iwona
Powiązania:: https://bibliotekanauki.pl/articles/1395690.pdf
Data publikacji:: 2014-01-01
Wydawca:: Index Copernicus International
Tematy:: laparoscopic surgery
cholecystectomy
iatrogenic bile duct injury
Opis:: Laparoscopic cholecystectomy is one of the most frequently performed surgical procedures in surgical wards. Iatrogenic bile duct injuries (IBDI) incurred during the procedures are among postoperative complications that are most difficult to treat. The risk of bile duct injury is 0.2-0.4%, and their consequences are unpleasant both for the surgeon and for the patient. The aim of the study was analysis of iatrogenic bile duct injuries and methods of their repair,taking into consideration the circumstances, under which the injuries occur. Material and methods. The study group consisted of 16 patients who had suffered IBDI during surgery. The analysed parameters included sex, age, indications for surgery, the setting of the surgical procedure and the type of bile duct injury. Additionally, the time of injury diagnosis, type of repair and treatment outcome were assessed. The IBDI analysis used the EAES classification of injuries. The time of IBDI repair was defined as immediate, early or late,depending on the time that had passed from the injury. The analysis included complications seen after bile duct repair. Results. The study group consisted of 10 women and 6 men, aged 29-84. Patients underwent 6 classic cholecystectomies, 8 laparoscopic cholecystectomies, one gastrotomy to remove oesophageal prosthesis and one laparotomy due to peptic ulcer. IBDI was diagnosed intraoperatively in 4 patients. In 12 patients IBDI was diagnosed within 1-7 days. The diagnosis was based on endoscopic retrograde cholangiopancreatography and the results of biochemistry tests. According to the EAES classification, the injuries were of type 1 (4 patients), type 2 (8 patients), type 5 (3 patients) and type 6 (1 patients). Reconstruction procedures were performed during the same anaesthesia session in 3 patients, and in the early period in 13 patients. The main procedure was Roux-en-Y anastomosis (12 patients), with the remaining including bile-duct suturing over a T-tube (3 patients) and underpinning of an accessory bile duct in the pocket left after gallbladder removal (1 patient). The most common reconstruction complications included bile leak (3 patients), recurrent cholangitis (3 patients) and bile duct stricture (2 patients). Mortality in the study group was 12.5%. Conclusions. The procedures of laparoscopic and classic cholecystectomy are associated with a risk of IBDI, especially in the presence of inflammatory state of the gall-bladder. IBDI is a complex complication: its treatment poses a challenge for the operating surgeon, and even the most careful treatment adversely affects the patient’s lifedue to complications.
Źródło:: Polish Journal of Surgery; 2014, 86, 1; 17-25
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Secretin, cholecystokinin and the biliary canalicular secretion in the rat
Autorzy:: Romanski, K W
Bochenek, W.J.
Unold, J.
Szczepaniak, M.
Powiązania:: https://bibliotekanauki.pl/articles/70531.pdf
Data publikacji:: 1995
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: biliary tree
secretin
biliary canalicular secretion
gastrointestinal hormone
gastrointestinal peptide
rat
biliary canalicular flow
cholecystokinin
bile acid
bile
Źródło:: Journal of Physiology and Pharmacology; 1995, 46, 2
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Peculiarities of liver functional state in the early period of cranioskeletal injury combined with bleeding, and its correction by cell therapy
Autorzy:: Zayets, T.A.
Gudyma, A.A.
Powiązania:: https://bibliotekanauki.pl/articles/1032349.pdf
Data publikacji:: 2014
Wydawca:: Uniwersytet Kazimierza Wielkiego w Bydgoszczy
Tematy:: crinoskeletal injury
hemorrhage
liver
biligenic
bile excretion
fetal cells
Opis:: During the early manifestations of traumatic disease as a result of cranioskeletal injury (CSI) the content of total bile acids in bile is significantly reduced, biliary excretion is slowed, lithogenic properties of bile are increased. Intraperitoneal injection of fetal nerve cells in 12 hours after causing an injury accompanied by improvement of biligenic and biliary excretion liver functions, reduces the lithogenic properties of bile.
Źródło:: Journal of Health Sciences; 2014, 4, 1; 383-390
1429-9623
Pojawia się w:: Journal of Health Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Reduction of bilirubin ditaurate by the intestinal bacterium Clostridium perfringens
Autorzy:: Koníčková, Renata
Jirásková, Alena
Zelenka, Jaroslav
Lešetický, Ladislav
Štícha, Martin
Vítek, Libor
Powiązania:: https://bibliotekanauki.pl/articles/1039751.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: bilirubin ditaurate
bile pigments
urobilinoids
intestinal metabolism
Clostridium perfringens
Opis:: Bilirubin is degraded in the human gut by microflora into urobilinoids. In our study we investigated whether the bilirubin-reducing strain of Clostridium perfringens can reduce bilirubin ditaurate (BDT), a bile pigment of some lower vertebrates, without hydrolysis of the taurine moiety. C. perfringes was incubated under anaerobic conditions with BDT; reduction products were quantified by spectrophotometry and separated by TLC. Based on Rf values of BDT reduction products and synthetic urobilinogen ditaurate, three novel taurine-conjugated urobilinoids were identified. It is likely that bilirubin-reducing enzyme(s) serve for the effective disposal of electrons produced by fermentolytic processes in these anaerobic bacteria.
Źródło:: Acta Biochimica Polonica; 2012, 59, 2; 289-292
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Reprinted with permission of editor-in-chief of Annals of Surgery: Annals of Surgery: Vol. 266, nr 5, November 2017; 703 - 705: Modern Surgeons: Still Masters of Their Trade or Just Operators of Medical Equipment?
Autorzy:: Krawczyk, Marek
Powiązania:: https://bibliotekanauki.pl/articles/1392874.pdf
Data publikacji:: 2018
Wydawca:: Index Copernicus International
Tematy:: vascular surgery
cholecystectomy
ultrasonography
bile ducts
liver transplantation
pancreas
laparoscopy
Opis:: My surgical education began at a time when Poland formed part of the communist bloc and was isolated from the world, or in today’s Terms – it remained behind the Iron Curtain. This was true of all areas of life, including medicine. When after 40 years of work, I look back at my professional career; I wonder whether I owe my proficiency in surgery to my experience and dexterity or, like many others, to technological progress. Two of the great Polish surgeons were my mentors and teachers. Professor Zdzisław Łapiński was the one I met first. He was a manual genius and an unusual operational strategist. Granted, he had one character defect, but nobody’s perfect after all. In 1975, I defended my dissertation. I was convinced that I should continue my education at a center abroad, preferably within a postdoctoral scholarship. Professor Łapiński wanted me to learn everything about surgery from him. I decided otherwise, and in 1978 with his tacit agreement, I obtained a Humboldt Fellowship and went to Heidelberg, to the department headed by none other than Professor Fritz Linder.1 I started my research for the habilitation thesis at the Experimentelle Chirurgie Abteilung of his Department.
Źródło:: Polish Journal of Surgery; 2018, 90, 2; 1-4
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Rola 7α- hydroksylazy cholesterolu i genu CYP7A1 w fizjologii i patologii człowieka
Role of the cholesterol 7α- hydroxylase and CYP7A1 gene in human physiology and pathology
Autorzy:: Iwanicki, Tomasz
Balcerzyk, Anna
Żak, Iwona
Powiązania:: https://bibliotekanauki.pl/articles/1039371.pdf
Data publikacji:: 2010
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Tematy:: cyp7a1
kwasy żółciowe
cholesterol
polimorfizm
polymorphism
bile acids
Opis:: Cholesterol 7α- hydroxylase (CYP7A1) belongs to the big family of cytochrome p450. Biological significance of cholesterol 7α- hydroxylase is associated with beginning of cholesterol transformation to the bile acids. CYP7A1 affinity to the cholesterol is determined by its unique protein structure, different from the other proteins of cytochrome p450 family. CYP7A1 enzyme is enoded by CYP7A1 gene localized in short arm of chromosome 8. Expression of CYP7A1 gene could be regulated by farnesoid X receptor (FXR) or by kinases, which modulate nuclear receptor`s binding abilities to the gene promoter. Polymorphic variants and mutations present in the promoter region impact on the quality properties of the enzyme. CYP7A1 gene, encoding key enzyme of the cholesterol catabolic pathway is a main candidate to the research of its association with changes of serum lipids levels. Presence of genetic variants can be associated with changed levels of total cholesterol, triglycerides and Low- density lipoproteins (LDL). Promoter polymorphism of CYP7A1 is also main candidate for the research of association with such disease entities as gallbladder stone formation, colon cancer, gallbladder cancer or atherogenic- based diseases.
7α- hydroksylaza cholesterolu (CYP7A1) jest enzymem należącym do dużej rodziny cytochromu p450. Znaczenie biologiczne 7α- hydroksylazy cholesterolu związane jest z rozpoczęciem szeregu przemian cholesterolu do kwasów żółciowych. Powinowactwo CYP7A1 do cholesterolu determinowane jest unikalną budową białka, odmienną od reszty białek rodziny cytochromu p450. Enzym ten kodowany jest przez gen CYP7A1, którego locus znajduje się na ramieniu krótkim chromosomu ósmego. Ekspresja tego genu może być regulowana przy udziale farnezylowego receptora X (FXR), bądź zachodzić poprzez szereg kinaz białkowych, modulujących zdolność przyłączania się swoistych receptorów jądrowych do promotora CYP7A1. Warianty polimorficzne i mutacje, występujące w regionie promotorowym, wpływają na właściwości jakościowe enzymu. Gen CYP7A1, kodując kluczowy enzym w katabolizmie cholesterolu, jest głównym kandydatem do badań jego związku ze zmianami w osoczowym poziomie lipoprotein. Obecność wariantów genetycznych w promotorze genu CYP7A1 może być związana ze zmienionym poziomem cholesterolu całkowitego, triacylogliceroli czy LDL (Low- Density Lipoprotein). Polimorfizm promotora genu kodującego kluczowy enzym szlaku syntezy kwasów żółciowych i usuwania cholesterolu z organizmu jest głównym kandydatem do badań asocjacyjnych z takimi jednostkami chorobowymi, jak kamica żółciowa, nowotwory jelita grubego i woreczka żółciowego czy choroby o podłożu miażdżycowym.
Źródło:: Annales Academiae Medicae Silesiensis; 2010, 64, 3-4; 48-57
1734-025X
Pojawia się w:: Annales Academiae Medicae Silesiensis
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Ultrasound imaging of the liver and bile ducts – expectations of a clinician
Badanie ultrasonograficzne wątroby i dróg żółciowych – oczekiwania klinicysty
Autorzy:: Skoczylas, Krzysztof
Pawełas, Andrzej
Powiązania:: https://bibliotekanauki.pl/articles/1053137.pdf
Data publikacji:: 2015
Wydawca:: Medical Communications
Tematy:: CEUS
bile ducts
elastography
fatty liver
ceus
drogi żółciowe
elastografia
stłuszczenie wątroby
Opis:: Since diseases of the liver and bile ducts are common, a clinician is faced by the need to implement an appropriate diagnostic process. It is necessary to apply diagnostic methods that enable appropriate assessment of the most common pathologies of the liver, i.e. fibrosis, steatosis and focal lesions, as well as initial assessment of the bile ducts. These goals can be achieved using ultrasound methods based on conventional sonography, contrast-enhanced sonography and elastography. The assessment of fatty liver and bile duct dilatation using ultrasound reaches satisfactory levels of sensitivity and specificity. The usage of contrast agents enables unambiguous differentiation between benign and malignant focal lesions, frequently allowing them to be identified accurately without the assistance of other imaging modalities. Elastography has enabled reliable assessment of liver fibrosis. Its results are comparable to those of the standard method, i.e. liver biopsy.
W związku z powszechnym występowaniem chorób wątroby i dróg żółciowych klinicysta stoi przed problemem wdrożenia odpowiedniej diagnostyki. Istnieje potrzeba stosowania metod diagnostycznych umożliwiających odpowiednią ocenę najczęstszych patologii wątroby, to jest włóknienia, stłuszczenia miąższu wątroby, różnicowania zmian ogniskowych, czy wstępną ocenę patologii dróg żółciowych. Na osiągnięcie tych celów pozwala zastosowanie metod ultrasonograficznych opartych na klasycznej ultrasonografii, ultrasonografii z wykorzystaniem kontrastów dożylnych i elastografii. Ultrasonograficzna ocena stłuszczenia wątroby i poszerzenia dróg żółciowych osiąga zadowalającą czułość i specyficzność. Zastosowanie kontrastów dożylnych pozwala na jednoznaczne różnicowanie między łagodnymi a złośliwymi zmianami ogniskowymi, często umożliwiając prawidłową ich identyfikację bez konieczności stosowania innych metod badań obrazowych. Zastosowanie metody elastografii umożliwiło wiarygodną ocenę włóknienia wątroby, z wynikami porównywalnymi do standardowej metody, jaką jest biopsja wątroby.
Źródło:: Journal of Ultrasonography; 2015, 15, 62; 292-306
2451-070X
Pojawia się w:: Journal of Ultrasonography
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Interstitial Cajal-Like Cells and Bile Lithogenicity in the Pathogenesis of Gall-Stone Disease
Autorzy:: Pasternak, Artur
Matyja, Andrzej
Gil, Krzysztof
Gajda, Mariusz
Tomaszewski, Krzysztof A.
Matyja, Maciej
Walocha, Jerzy A.
Kulig, Jan
Powiązania:: https://bibliotekanauki.pl/articles/1396274.pdf
Data publikacji:: 2013-06-01
Wydawca:: Index Copernicus International
Tematy:: bile lithogenecity
interstitial Cajal-like cells
gall-stone disease
c-Kit
mast cells
Opis:: Gall-stone disease constitutes a serious clinical problem and is the most frequent cause of elective cholecystectomies. There are many etiopatogenic factors however; lithogenic bile and its stasis due to gall-bladder hypomotility seem to be the most important. In recent years discovery of pacemaker function of Interstitial Cells of Cajal changed our understanding of smooth muscle physiology and helped to disclose many gastrointestinal motility disorders. The aim of the study was identification and quantification of interstitial Cajal-like cells (ICLCs) in gall-bladder muscle wall from patients with cholelithiasis and in gall-stone-free controls, as well as determination of the relationship between the number of ICLCs and Cholesterol Saturation Index (CSI) of bile in both analyzed groups. Material and methods. 20 patients operated for symptomatic cholelithiasis were enrolled into the study group. The control group consisted of 20 patients operated for pancreatic head tumors, with no pre- and intraoperative signs of gall-stones. Identification of ICLCs in the gall-bladder was performed by means of double immunofluorescence technique with anti c-Kit and anti-mast cell tryptase antibodies. Quantitative analysis was carried out under fluorescence microscopy conjoined with image analysis software. Bile samples were used for calculation of CSI. Results. ICLCs were detected within gall-bladder muscle wall. Number of ICLCs was statistically significantly lower in patients from the study group as compared to control. The study also revealed statistically significantly higher CSI in the study group. Conclusions. The quantity of ICLCs is diminished in the gall-bladder from patients with cholelithiasis and there is negative correlation between the number of ICLCs and CSI of bile. Regarding the role of ICCs in regulation of GI tract motility, it appears that reduction in their number may be important etiopatogenic factor of cholelithiasis.
Źródło:: Polish Journal of Surgery; 2013, 85, 6; 311-316
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Modelling of the pathological bile flow in the duct with a calculus
Autorzy:: Kuchumov, A. G.
Nyashin, Y. I.
Samarcev, V. A.
Gavrilov, V. A.
Powiązania:: https://bibliotekanauki.pl/articles/307046.pdf
Data publikacji:: 2013
Wydawca:: Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:: biliary system
bile flow
non-Newtonian fluid
Vater’s papilla
przepływ żółci
płyn nienewtonowski
Opis:: The aim of the present paper is to develop an analytical model for description of the pathological bile flow in the major duodenal papilla duct with a calculus. The problem is separated into two parts. The first part deals with determination of bile behaviour and constitutive relation parameters of the pathological bile. The viscosity vs. shear rate, the viscosity vs. time, and shear stress vs. shear rate dependences are obtained for different types of bile taken from patients of different age and sex. As a result, the approximation of curves described by the Casson equation was obtained. It was shown that the pathological bile is a thixotropic non-Newtonian fluid. The second part is directly related to modelling of the bile flow in the duct with a calculus. As a result of solving the problem, the bile velocity profile, flow rate vs. time, and bile pressure vs. calculus radius were obtained. The dependences obtained may play an important role in the assessment of an indication to operation.
Źródło:: Acta of Bioengineering and Biomechanics; 2013, 15, 4; 9-17
1509-409X
2450-6303
Pojawia się w:: Acta of Bioengineering and Biomechanics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Investigation on adsorption of fatty and bile acids in the presence of dietary supplements containing chromium
Badanie sorpcji kwasow tluszczowych i cholowych w obecnosci suplementow diety zawierajacych chrom
Autorzy:: Meler, J
Grimling, B.
Pluta, J.
Powiązania:: https://bibliotekanauki.pl/articles/14261.pdf
Data publikacji:: 2010
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:: adsorption
fatty acid
bile acid
dietary supplement
chromium
chitosan
bioavailability
in vitro model
macroelement
microelement
Opis:: Dietary supplements contain not only macro- and microelements, but also elements which affect human metabolism. Many products available on the market contain chromium compounds together with chitosan used as a dietary supplement enhancing the digestion of lipids. The studies involved natural chitosan from krill available on the market, with the deacetylation degree of 85 to 95%, and dietary supplements containing chitosan (Vitana®, Hitec Nutrition®) as well as a product containing ionic chromium with niacin and several aminoacids — Chromdiet®). The study has determined the capability of binding fatty and bile acids by dietary supplements containing chitosan and chromium. The process of lipids and bile acids adsorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions. The findings prove that extracts of fatty acids and bile acids undergo adsorption by various kinds of adjuvant substances found in dietary supplements, which confirms a significant effect of these polymers on the bioavailability of fatty and bile acids in a human organism. The addition of chromium to a supplement does not effect the capability of chitosan to bind fatty and bile acids. Mean adsorption of bile acids by 1 g of the polymer (chitosan, inulin, fibre) ranges from 0.9 g to 1.79 g depending on the pH (which decreases the bioavailability of lipids by 15-30%).
Suplementy diety to nie tylko makro- i mikroelementy, ale tez pierwiastki, które wykazują wpływ na przemiany metaboliczne organizmu. Obecnie na rynku jest sporo preparatów zawierających związki chromu wraz z chitozanem stosowanych jako dodatek żywieniowy wspomagający trawienie tłuszczowców. W pracy przebadano naturalny chitozan z kryla o stopniu deacetylacji od 85 do 95% występujący obecnie w sprzedaży rynkowej oraz preparaty zawierające chitozany, stosowane jako suplementy diety (Vitana®, Hitec Nutrition® oraz preparat zawierający chrom—Chromdiet®). Określono zdolności wiązania tłuszczowców i kwasów żółciowych przez suplementy diety zawierające chrom i chitozan. Zjawisko adsorpcji lipidów i kwasów żółciowych badano metodą dynamiczną w modelu biofarmaceutycznym imitującym warunki in vitro. Otrzymane wyniki dowodzą, że kwasy tłuszczowe i ekstrakty kwasów żółciowych ulegają adsorpcji przez różnego rodzaju substancje pomocnicze służące do wytworzenia suplementu diety, co potwierdza znaczący wpływ tych polimerów na biodostępnośc kwasów tłuszczowych i żółciowych w organizmie człowieka. Średnia wielkość adsorpcji kwasów żółciowych przez 1 g polimeru w zależności od pH środowiska mieściła się w granicach od 0,90 g do 1,79 g (daje to zmniejszenie biodostępności tłuszczowców o 15-30%).
Źródło:: Journal of Elementology; 2010, 15, 1; 141-147
1644-2296
Pojawia się w:: Journal of Elementology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Standardy badań ultrasonograficznych Polskiego Towarzystwa Ultrasonograficznego – aktualizacja. Badanie wątroby, pęcherzyka i dróg żółciowych
Standards of the Polish Ultrasound Society – update.
Autorzy:: Walas, Maria Krystyna
Skoczylas, Krzysztof
Gierbliński, Ireneusz
Powiązania:: https://bibliotekanauki.pl/articles/1061161.pdf
Data publikacji:: 2012
Wydawca:: Medical Communications
Tematy:: bile ducts
elastography
gallbladder diseases
liver diseases
choroby pęcherzyka żółciowego
choroby wątroby
elastografia
standardy badania
Opis:: Ultrasonography, which usually constitutes an initial imaging method of the gallbladder, liver and bile ducts diseases, allows for final diagnosis or determines another diagnostic step. The continuously progressing technological advancement forces to broaden the indications for ultrasound diagnostics and enables easier and more precise imaging of the tested structures. Performing the examination in accordance with current standards allows for the optimization of the sensitivity and specificity parameters of ultrasound examinations in the diagnosis of the liver, gallbladder and bile ducts pathologies as well as minimizes the probability of error-making. This article presents a recommended liver, gallbladder and bile ducts ultrasound technique which indicates an optimal positioning of the patient for the exam as well as the sites of the ultrasound transducer application. Minimum technical parameters of the apparatus have been specified with respect to the requirements of modern ultrasound techniques which enable imaging with the use of contrast agents and elastography. Furthermore, the article proposes a standard exam description containing essential patient-related data and provides required ultrasound evaluation parameters for the tested organs. Attention has been drawn to the appropriate manner of preparing the patient for the examination and the features of the tested structures have been presented. The article also contains a brief description of the liver, gallbladder and bile ducts diseases which are most often diagnosed by ultrasound examinations. Moreover, the use of elastography as well as contrast-enhanced examinations in the diagnostics of fibrosis and focal changes in the liver have been discussed. This article has been prepared on the basis of the Ultrasound Examination Standards of the Polish Ultrasound Society (2011) and updated with reference to the latest findings in pertinent literature.
Ultrasonografia jest zwykle wyjściową metodą obrazowania chorób pęcherzyka żółciowego, wątroby i dróg żółciowych, pozwalającą na ustalenie ostatecznego rozpoznania lub determinującą dalszy tor diagnostyczny. Stale postępujący rozwój technologiczny wymusza poszerzanie wskazań do diagnostyki ultrasonograficznej i ułatwia precyzyjne obrazowanie ocenianych struktur. Wykonanie badania zgodnie z obowiązującymi standardami pozwala na optymalizację parametrów czułości i swoistości ultrasonografii w rozpoznawaniu patologii wątroby, pęcherzyka żółciowego, dróg żółciowych i minimalizuje prawdopodobieństwo popełniania błędów. W pracy przedstawiono zalecaną technikę wykonywania badania ultrasonograficznego wątroby, pęcherzyka żółciowego i dróg żółciowych, wskazując na optymalne ułożenie pacjenta do badania i miejsce przyłożenia głowicy ultrasonograficznej. Określono minimalne parametry techniczne aparatury, uwzględniając wymagania nowoczesnych technik ultrasonograficznych, umożliwiających badania z wykorzystaniem środków kontrastowych i elastografii. Ponadto zaproponowano w niej standard opisu badania zawierający niezbędne dane dotyczące pacjenta i wymagane parametry oceny ultrasonograficznej badanych narządów. Zwrócono uwagę na właściwy sposób przygotowania pacjenta do badania oraz przedstawiono cechy prawidłowej budowy ocenianych struktur. W artykule zamieszczono także krótką charakterystykę najczęściej rozpoznawanych ultrasonograficznie chorób wątroby, pęcherzyka i dróg żółciowych. Ponadto omówiono zastosowanie elastografii i badań z użyciem środków kontrastujących w diagnostyce włóknienia oraz zmian ogniskowych w wątrobie. Praca została przygotowana na podstawie Standardów badań ultrasonograficznych Polskiego Towarzystwa Ultrasonograficznego (2011) i zaktualizowana w oparciu o najnowsze doniesienia z piśmiennictwa.
Źródło:: Journal of Ultrasonography; 2012, 12, 51; 428-445
2451-070X
Pojawia się w:: Journal of Ultrasonography
Dostawca treści:: Biblioteka Nauki

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