- Tytuł:
- Synthesis and Characterization of N-Methyl Indole Derivatives via Desulfitative Displacement by Various Amines and Its Antimicrobial Activity
- Autorzy:
-
Chodvadiya, Vijay D.
Pambhar, Kaushik D.
Parmar, Nilesh D.
Dhamsaniya, Ashish P.
Safi, Shahrukh khan A.
Chhatbar, Pratiksha V.
Ram, Hemal N.
Khunt, Ranjan C.
Patel, P. K. - Powiązania:
- https://bibliotekanauki.pl/articles/1065130.pdf
- Data publikacji:
- 2019
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
Anti-microbial agents
Desulfitative displacement
N-methyl indole
S-methyl - Opis:
- A modular three step synthetic approach of N-methyl indole derivatives has been carried out by the condensation of N-methyl indole with cyanoacetic acid using acetic anhydride as solvent to yield 3-cyanoacetyl N-methyl indole, which further reacts with carbon disulphide and methyl iodide in basic condition to obtain 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis(methylthio)acrylonitrile as a scaffold. Subsequent, the scaffold when reacts with substituted various amine derivatives via desulfitative displacement forms new derivatives of 3-((substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio)acrylonitrile in moderate to good yields. All the novel compounds were evaluated for their antimicrobial activity against Gram+ve and Gram-ve bacteria and different fungal species which demonstrated well to moderate antimicrobial activity.
- Źródło:
-
World Scientific News; 2019, 120, 2; 181-191
2392-2192 - Pojawia się w:
- World Scientific News
- Dostawca treści:
- Biblioteka Nauki
Artykuł