Temat: anti-angiogenesis - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: The scheduling of angiogenic inhibitors minimizing tumor volume
Autorzy:: Ledzewiecz, U.
Marriott, J.
Maurer, H.
Schättler, H.
Powiązania:: https://bibliotekanauki.pl/articles/332886.pdf
Data publikacji:: 2008
Wydawca:: Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:: modelowanie biomatematyczne
kontrola optymalna
sterowanie optymalne
guz antyangiogenny
uzyskiwanie protokołów
biomathematical modelling
optimal control
tumor anti-angiogenesis
realizable protocols
Opis:: The efficiency of piecewise constant protocols with a small number of switchings is investigated for a mathematical model of tumor anti-angiogenesis formulated originally by Hahnfeldt et al. in [8]. By comparing with the theoretically optimal solution derived earlier [12] it will be seen that for the problem of minimizing the primary cancer volume with a given amount of angiogenic inhibitors to be administered constant protocols already provide very good suboptimal strategies.
Źródło:: Journal of Medical Informatics & Technologies; 2008, 12; 23-28
1642-6037
Pojawia się w:: Journal of Medical Informatics & Technologies
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: Singular controls and chattering arcs in optimal control problems arising in biomedicine
Autorzy:: Ledzewicz, U.
Schattler, H.
Powiązania:: https://bibliotekanauki.pl/articles/970774.pdf
Data publikacji:: 2009
Wydawca:: Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:: optimal control
singular controls
biomedical models
anti-angiogenesis
Opis:: We consider an optimal control problem of the Mayer-type for a single-input, control affine, nonlinear system in small dimension. In this paper, we analyze effects that a modeling extension has on the optimality of singular controls when the control is replaced with the output of a first-order, time-invariant linear system driven by a new control. This analysis is motivated by an optimal control problem for a novel cancer treatment method, tumor anti-angiogenesis, when such a linear differential equation, which represents the pharmacokinetics of the therapeutic agent, is added to the model. We show that formulas that define a singular control of order 1 and its associated singular arc carry over verbatim under this model extension, albeit with a different interpretation. But the intrinsic order of the singular control increases to 2. As a, consequence, optimal concatenation sequences with the singular control change and the possibility of optimal chattering arcs arises.
Źródło:: Control and Cybernetics; 2009, 38, 4B; 1501-1523
0324-8569
Pojawia się w:: Control and Cybernetics
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 3.

Tytuł:: Mathematical modelling of tumour angiogenesis
Autorzy:: Poleszczuk, Jan Tadeusz
Powiązania:: https://bibliotekanauki.pl/articles/748455.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Matematyczne
Tematy:: tumour angiogenesis
anti-angiogenic therapy
ODEs
Opis:: Mathematical models prove valuable tools to study the proof-of-concept and underlying mechanisms of a tumour progression. They enable us to explore possible radio-, chemo- and various therapy combinations that until now have been only a promising hypothesis because of huge costs of their clinical studies. Here we present a family of mathematical models of tumour angiogenesis, which were successfully compared to biological data. In addition, after modifications they can describe the effect of anti-angiogenic treatment for various vessels targeting agents, as well as the impact of cytotoxic agents on proliferating cancer cells. We present two ways in which the anti-angiogenic treatment cam be incorporated into the model. One describes the agents directly targeting tumour vessels, whereas the second focuses on agents interfering with angiogenic signalling. We illustrate differences between those two approaches by presenting fitting results to biological data.
Źródło:: Mathematica Applicanda; 2013, 41, 1
1730-2668
2299-4009
Pojawia się w:: Mathematica Applicanda
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "anti-angiogenesis" wg kryterium: Temat

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język