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    Tytuł:
    Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis
    Autorzy:
    Zuwała-Jagiełło, Jolanta
    Pazgan-Simon, Monika
    Simon, Krzysztof
    Warwas, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1039949.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    advanced oxidation protein products
    cirrhosis
    inflammatory markers
    Opis:
    Advanced oxidation protein products (AOPPs) are protein markers of oxidative stress with pro-inflammatory properties that accumulated in liver cirrhosis. In the present study, we investigated the association between chronic inflammatory response triggered by AOPPs and the severity of liver disease as assessed by the Child-Pugh score. Plasma concentrations of AOPPs and inflammatory markers such as C-reactive protein, tumor necrosis factor-α, and interleukin-6 were measured in 41 patients with HCV-related cirrhosis, 43 patients with alcohol-related liver cirrhosis (ALC), and in 30 age and sex matched controls. In comparison with controls, AOPPs were increased in HCV-related compensated (Child-Pugh A) and decompensated (Child-Pugh B-C) cirrhosis and in alcohol-related compensated cirrhosis. AOPPs level positively correlated with Child-Pugh score in alcohol-related cirrhosis but not in HCV-related cirrhosis and the correlation with the indices of chronic inflammation was stronger in ALC. In turn, AOPPs in HCV-related cirrhosis was related to inflammation to a lesser extent, but a significant correlation with antioxidant defense could be noted. In summary, liver cirrhosis was associated with increased formation of AOPPs, which differed between alcohol-related and HCV-related cirrhosis with respect to the relationship between AOPPs and antioxidant defense, stage of liver cirrhosis, and inflammatory response. The significant correlation between AOPPs accumulation and indices of chronic inflammation, more specifically TNF-α, suggests that oxidative stress may be a mediator of chronic inflammatory state in the early stage of alcohol-related cirrhosis.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 1; 59-65
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Elevated advanced oxidation protein products levels in patients with liver cirrhosis
    Autorzy:
    Zuwała-Jagiełło, Jolanta
    Pazgan-Simon, Monika
    Simon, Krzysztof
    Warwas, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1040488.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    advanced oxidation protein products
    AGEs
    cirrhosis
    Opis:
    Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 4; 679-685
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biomarkery wykorzystywane w ocenie oksydacyjnych uszkodzeń białek
    Biomarkers of proteins oxidative damage
    Autorzy:
    Ognik, Katarzyna
    Cholewińska, Ewelina
    Powiązania:
    https://bibliotekanauki.pl/articles/1033871.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Tematy:
    3-nitrotyrosine
    advanced oxidation protein products
    biomarker
    oxidative stress
    protein
    protein carbonyl
    białko
    3-nitrotyrozyna
    pochodne karbonylowe
    stres oksydacyjny
    zaawansowane produkty utleniania białek
    Opis:
    Przewaga procesów prooksydacyjnych w organizmie skutkuje wystąpieniem stresu oksydacyjnego objawiającego się m.in. utlenianiem białek. Bezpośrednia analiza ilości reaktywnych form tlenu i azotu jest zadaniem bardzo trudnym, dlatego w ocenie nasilenia stresu oksydacyjnego częściej wykorzystuje się markery uszkodzeń, powstające w wyniku reakcji wolnych rodników z białkami. Są one o wiele trwalsze, a przez to łatwiejsze do analizy. Wśród najważniejszych biomarkerów oksydacyjnych uszkodzeń białek wyróżnia się pochodne karbonylowe, 3-nitrotyrozynę, S-nitrotriazole, kynureninę, 3-chlorotyrozynę, bromotyrozynę, sulfotlenek metioniny, dityrozynę, oksohistydynę oraz tzw. zaawansowane produkty oksydacji białek (AOPP).
    W ocenie oksydacyjnych uszkodzeń białek u zwierząt laboratoryjnych najlepiej sprawdzają się pochodne karbonylowe, 3-nitrotyrozyna i AOPP. Ich zawartość w ustroju wyraźnie wzrasta w odpowiedzi na stres oksydacyjny wywołany takimi czynnikami, jak: niewłaściwa dieta, niedobór mikroelementów, zatrucie substancjami toksycznymi, infekcje czy starzenie.
    The prevalence of prooxidative processes in the body is associated with development of oxidative stress, one of the symptoms of which is oxidation of proteins. Direct analysis of the amount of reactive forms of oxygen and nitrogen is a very difficult task. Therefore, in assessing the severity of oxidative stress, markers generated by free radical reactions with proteins are often used. They are much more durable and thus easier to analyze. The most important biomarkers of oxidative damage of proteins are protein carbonyl compounds, 3-nitrothyrosine, S-nitrotriazoles, kynurenine, 3-chlorothyrozine, bromothyroxine, methionine sulfoxide, dithyrosine, oxohistidine and and so called advanced oxidation protein products (AOPP).
    Protein carbonyls, 3-nitrotyrosine and AOPP are the best indicators for evaluating of oxidative damage of proteins in laboratory animals. Their content in the body is clearly increasing in response to oxidative stress caused by such factors as improper diet, micronutrient deficiencies, toxic poisoning, infections or aging.
    Źródło:
    Kosmos; 2018, 67, 2; 347-359
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients
    Autorzy:
    Dziedzic, Marcin
    Orłowska, Ewelina
    Petkowicz, Beata
    Bednarek-Skublewska, Anna
    Solski, Janusz
    Goździewska, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/991106.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    renalase
    advanced oxidation protein products
    catecholamines
    haemodialysis
    Opis:
    Introduction. The main mediators of the sympathetic nervous system in the effectors part are catecholamines (CA). An increased sympathetic nerve activity observed in chronic kidney disease (CKD), is due to a raised level of CA in plasma. Renalase is a protein secreted by the kidneys, composed of 342 amino acids, which is able to metabolize the circulating CA and possibly play an important role in the regulation of sympathetic tone and blood pressure. Also, oxidative stress, defined as a disruption of the equilibrium between the generation of oxidants, is a crucial factor in the development of the inflammatory syndrome associated with CKD. The advanced oxidation protein products (AOPP) represent exquisite markers of phagocyte-derived oxidative stress. Objective. The aim of the study was to investigate the concentration of renalase and explore the associations between AOPP with regards to CA in haemodialysis (HD) patients. Materials and method. The study was conducted among 50 residents of the municipality and neighbouring villages in the province of Lublin, central-eastern Poland. Results. In the studied patients, it was found that an average concentration of renalase was 44.8 ± 6.5 μg/mL, whereas of AOPP plasma levels – 57.5 ± 21.5 μmol/L. The results demonstrated the correlation between levels of renalase and AOPP in the HD patients. Indeed, elevated levels of renalase and AOPP in HD may be due to the presence of uremic toxins in blood. The concentration of urea affects the plasma concentrations of AOPP and renalase causing a direct relationship between renalase and AOPP. However, there is no clear relationship between renalase and circulating catecholamines in HD patients.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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