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    Tytuł:
    Higher Apoptosis Index and Proliferation Index in Colonocytes of Patients with Ulcerative Colitis in Remission
    Autorzy:
    Buczyński, Jarosław
    Spychalski, Michał
    Ławska-Wierzchniewska, Agnieszka
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1396694.pdf
    Data publikacji:
    2012-06-01
    Wydawca:
    Index Copernicus International
    Tematy:
    apoptosis
    proliferation
    ulcerative colitis
    Opis:
    Ulcerative colitis (UC) is a inflammatory disease of large bowel. The amount of people suffering from UC increases from year to year. Pathogenesis of this affection is still not entirely clear. Mechanisms of proliferation and apoptosis in colonocytes in the course of the disease are defectedThe aim of the study was to assess the rate of proliferation and intensity of apoptosis in colonocytes in patients with diagnose UC.Material and methods. Colon pathological samples taken from patients with diagnosed ulceraive colitis were examined. Patients were in both clinical and endoscopic remission and were treated with mesalazin. They were patient of Department of General and Colorectal Surgery. To estimate proliferation index dye with monoclonal antibody against Ki67. To determine apoptosis level immunohistochemistry with antybody against Bax was used.Results. Average Ki-67 in the test group was 42,13%, the largest value amounted to 57% and the lowest of 33%. Average value of Bax was 1.47 and ranged between 0-3. High index of bax appear not only in the bottom of the crypt, but also at their outlet.Conclusions. In ulecerative colitis genetic and immunological disturbances occur despite treatment. Mesalazine acting only on certain routes associated with the UC holds the remission, without, however "the molecular remission". Thus, it appears that the results of our research are another proof of the necessary caution in weaning support treatment.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 6; 271-275
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Infliximab in therapy of inflammatory bowels diseases
    Autorzy:
    Bar, Piotr
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454884.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    infliximab
    TNFα
    ulcerative colitis
    Opis:
    Introduction. Infliximab is a monoclonal antibody that acts against tumor necrosis factor TNF-α. The drug is used in the treatment of autoimmune diseases. Aim. This article reviewed the efficacy and safety of infliximab for the treatment in severe ulcerative colitis. This review included studies that evaluated the clinical use of infliximab. Material and methods. This meta-analysis was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Infliximab has been approved by the US Food and Drug Administration (FDA) as a medicine to treat Leśniowski and Crohn’s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. However, further trials are required to compare other parameters of efficacy such as the clinical response with infliximab. Conclusion. In patients suffering from Crohn’s disease or ulcerative colitis under infliximab maintenance therapy, sustained good trough levels are associated with: better response and remission rates, more mucosal healing and less loss of response.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 79-82
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of socio-demographic and clinical factors on the process of acceptance of the disease among patients with ulcerative colitis
    Autorzy:
    Chrobak-Bień, Joanna
    Gawor, Anna
    Paplaczyk, Małgorzata
    Małecka-Panas, Ewa
    Gąsiorowska, Anita
    Powiązania:
    https://bibliotekanauki.pl/articles/1392911.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    Acceptance of the disease
    ulcerative colitis
    Opis:
    Ulcerative colitis (UC) is a kind of inflammatory bowel disease involving rectal mucosa, or the rectum with colon, resulting in ulcerations in some cases. It is incurable and varies with periods of exacerbation and remission. The disease affects mainly population of highly-developed European or North American nations. It can relatively rarely be observed in South America, Asia and Africa. It is estimated that morbidity and incidence in those regions is about 10 times lower than in Europe and North America [1,2]. The incidence of UC in Europe is approximately 10 new cases per 100,000 people annually [3]. In Poland, epidemiology assessment is difficult due to a lack of reliable statistics. In Lower Silesia, 840 hospitalizations for UC on average are registered annually [4,5]. In UC pathogenesis, genetic, environmental and immunologic factors play an important role. UC can occur at any age, however, the peak incidence is observed between ages 20 and 40 and over 65 [6]. UC is incurable and accompanies the patient through the rest of his/her life. It varies with periods of exacerbation and remission, which impair everyday activities and lower patient’s quality of life. As a consequence, the patient generally feels bad, which is not only caused by gastrointestinal symptoms but also by emotional and psychological issues [7]. Nowadays, a clear tendency can be observed in medicine to include health and disease-related issues in biopsychosocial context, including social and psychological factors affecting the course of the disease. The assessment of such factors brings up a broader perspective on patient’s health problems [8]. Adjustment to the disease is important in many chronic diseases, which demand a change of the patient’s attitude and taking aspects such as acceptance of one’s disease into consideration [9]. The term ‘acceptance’ denotes adopting an opinion, judgment, belief, behavior, favorable attitude or to give a consent [10]. Accepting one’s disease means adjusting to limitations posed by it and accepting the associated disability. The consequences include accepting the limitations, not being self-sufficient, dependence on others and low self-esteem [11]. In a chronic and difficult therapeutic process, medical staff play the key role, in addition to other patient’s support. Bonding with other patients is an important regulating factor in the emotional sphere, while psychological counseling can turn out beneficial in accepting one’s new difficult life situation. The aim of the study was to evaluate the acceptance of the disease in patients with ulcerative colitis with respect to selected socio-demographic and clinical variables.
    Źródło:
    Polish Journal of Surgery; 2018, 90, 6; 6-12
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determinants of the level of anxiety and fears in a group of patients with ulcerative colitis
    Autorzy:
    Kózka, M.
    Skowron, W.
    Bodys-Ciupak, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/2083068.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    disease activity
    ulcerative colitis
    anxiety and fears
    Opis:
    Introduction. Ulcerative colitis is a chronic, inflammatory disease of the mucous membrane of the large intestine manifesting itself through diarrhoea with blood, mucous and pus. It progresses with periods of relapses and remissions. The treatment is a long-term process which should aim at improving the patient’s clinical condition and quality of life, as well as minimising the disease-related anxiety and fears. Objective. The aim of the study was recognition of the determinants of the level of anxiety and fears in a group of patients with ulcerative colitis. Materials and method. The prospective study comprised 102 patients with diagnosed ulcerative colitis. The data were collected by means of the following tools: Clinical Disease Activity Index, Rating Form of IBD Patients Concerns (RFIPC), and a questionnaire by the authors. Statistical parametric and non-parametric tests were used to analyse the data, depending on the type of scale and nature of the variable distribution. Results. Most of the patients (64%) were in the active phase of the disease. A high level of fear and anxiety occurred in 73% of the patients and concerned the impact of the disease, intimate life, complications and stigmatisation. The highest levels of fears and anxiety were observed in the field of complications and the impact of the disease on the patients’ lives. Conclusions. The disease activity and high levels of anxiety and fears influenced the psychosocial functioning of the patients with ulcerative colitis.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2019, 26, 2; 337-340
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Macro and micronutrient deficiency in inflammatory bowel diseases
    Autorzy:
    Jarmakiewicz, Sara
    Piątek, Dominika
    Filip, Rafał
    Powiązania:
    https://bibliotekanauki.pl/articles/454753.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    Crohn’s disease
    IBD
    ulcerative colitis
    vitamins
    Opis:
    Introduction. Inflammatory bowel disease (IBD) is group of global range inflammatory conditions. There has been a regular increase in the number of IBD cases. Patients exclude whole food groups from their diet fearing the emergence of disease symptoms or due to learning from unreliable sources. Doing so, they might deepen the already existing vitamin deficiencies which occur along with the shortage of many minerals. These deficiencies might intensify the disease process or cause a new one. The most common deficits pointed out by numerous researchers concern vitamin D, calcium, cobalamin, folic acid and iron. It is well worth introducing selenium, zinc and ascorbic acid into a diet because of their immunomodulating effect. Important aspect of the healing process is a personalized diet which is designed to compensate for, or prevent vitamin and mineral deficiencies. Aim. The purpose of the study was to review the literature about vitamin and mineral deficiency in Inflammatory Bowel Diseases. Materials and method. Analysis of literature
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 4; 342-348
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Quality of Life Considering Patients with Chronic Inflammatory Bowel Diseases - Natural and Parenteral Nutrition
    Autorzy:
    Raczkowska, Aneta
    Ławiński, Michał
    Gradowska, Aleksandra
    Zielińska-Borkowska, Urszula
    Powiązania:
    https://bibliotekanauki.pl/articles/1395848.pdf
    Data publikacji:
    2014-12-18
    Wydawca:
    Index Copernicus International
    Tematy:
    Crohn's disease
    ulcerative colitis
    quality of life
    Opis:
    One of the elements of treatment considering inflammatory bowel diseases is nutritional therapy. The duration of the above-mentioned depends on the prevalence of such symptoms as fever, bowel move-ments, length of the functioning gastrointestinal tract, stoma and intestinal fistula presence. Nutritional therapy is an essential element of successful treatment alongside pharmacological, surgical, and biological therapy, as well as other methods. Crohn's disease and ulcerative colitis considered as chronic diseases, lead towards physical and biopsychosocial disability, being responsible for the reduction in the quality of life. The aim of the study was to determine the quality of life after surgical procedures in case of patients diagnosed with Crohn's disease and ulcerative colitis, subjected to natural and parenteral nutrition. Material and methods. The study group comprised 52 patients from the Department of Gastroen-terology, Military Medical Institute, and Department of Surgery and Clinical Nutrition, Clinical Hospital in Warsaw. The study was performed between October, 2011 and April, 2012. The World Health Organization Quality of Life Instrument - Bref (WHOQOL-BREF) questionnaire was used to deter-mine the patients’ quality of life. conclusions. A lower quality of life was observed in case of patients subjected to parenteral nutrition, poor education, disease symptoms exacerbation, in the majority-rural inhabitants. The quality of life does not depend on gender, type of disease, family status, and additional medical care.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 9; 410-417
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The expression of apoptosis-related proteins in patients with ulcerative colitis
    Autorzy:
    Niewiarowska, K.
    Lebelt, A.
    Gryko, M.
    Pryczynicz, A.
    Famulski, W.
    Czyżewska, J.
    Kemona, A.
    Piekarska-Dymicka, V.
    Jagodzińska, D.
    Guzińska-Ustymowicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1916338.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Ulcerative colitis
    Bcl-xl
    Bax
    Bid
    Bcl-2
    Opis:
    Purpose: Recent literature data indicate a key role of apoptosis in the pathogenesis of inflammatory bowel disease. The aim of the study was to evaluate the expression of Bax, Bid, Bcl-2 and Bcl-xl in non-dysplastic and dysplastic epithelium in inflamated mucosa of patients with ulcerative colitis. Methods: The study consists of 18 patients with diagnosed ulcerative colitis. The expression of proteins was determined immunohistochemically. Results: Lack of Bax expression in normal epithelium of the inflamed intestinal mucosa (94.4%) and a weak expression of this protein were found in dysplastic glandular cells (67%). The Bax expression of dysplastic epithelium correlates with reduced severity of chronic inflammation (p<0.005). Bid expression in non-dysplastic glands was found in 67% of cases vs. 16% in dysplastic epithelium that was associated with the occurrence of epithelial erosions or ulcers (p<0.05). Moderate cytoplasmic expression of Bcl-xl was noted in 27.7% of patients in normal epithelium and in 66.1% within dysplastic lesions. Bcl-xl expression in dysplastic glandular cells correlated with the presence of neutrophils in the lamina propria (p <0.05). Conclusions: The immunohistochemical expressions of Bax, Bcl-2 and Bcl-xl increase and Bid protein expression decreases in dysplastic glandular tubes as compared to non-dysplastic intestinal epithelium in inflamed mucosa, which may suggest an imbalance of controlled cell death in ulcerative colitis.
    Źródło:
    Progress in Health Sciences; 2014, 4, 1; 75-82
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ulcerative colitis: effect on fertility and pregnancy
    Autorzy:
    Ouzounιdou, A.
    Koukourikos, K.
    Kourkouta, L.
    Tsaloglidou, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1917296.pdf
    Data publikacji:
    2015
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    ulcerative colitis
    Pregnancy
    Fertility
    Reproduction
    inflammatory bowel disease
    Opis:
    Introduction: Ulcerative colitis is one of the most interesting nosological entities of gastroenterology and internal medicine. This chronic autoimmune disorder of the digestive system, along with Crohn's disease, is a type of idiopathic inflammatory bowel disease. It mainly affects people during their peak reproductive age, i.e., 15 to 30 years old. It is characterized by diffuse mucosal inflammation of the large intestine, which is limited to the colon and shows alternating periods of exacerbations and remissions. Purpose: To review the world literature regarding the impact of the disease on fertility, the course of pregnancy, and consecutively, the outcome of pregnancy.Materials and methods: An extensive review of the recent national and international literature in electronic databases (Pubmed, Google Scholar) and in scientific journals was accomplished through the use of appropriate keywords. Results: The majority of women will have a chance of conceiving. For about 25% of them, conception will be achieved in the course of the disease and it will progress normally, resulting in a healthy fetal outcome. Infertility only occurs among men while they are taking medicines, whereas among women it occurs after surgery for ileoanal anastomosis. During periods of flare-ups, there is a possibility of spontaneous abortion, premature labor and birth of an infant with low birth weight. The majority of pharmaceutical formulations can be used safely both before and after pregnancy without causing any birth defects.
    Źródło:
    Progress in Health Sciences; 2015, 5, 1; 185-191
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Awareness of smoking in adolescents with inflammatory bowel disease
    Autorzy:
    Dziekiewicz, M.
    Kowalska-Duplaga, K.
    Baranowska-Nowak, M.
    Nieścioruk, M.
    Kuźniarski, S.
    Banasiuk, M.
    Banaszkiewicz, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085373.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Crohn’s disease
    ulcerative colitis
    environmental factors
    tobacco
    Opis:
    Introduction and objectives. Inflammatory bowel disease (IBD) is long life disease that results from an interaction between a polygenetic predisposition and environmental factors, including smoking. The aim of this study was to evaluate beliefs about and awareness of smoking among adolescents with IBD compared to healthy controls. Materials and method. Patients with IBD, Crohn’s disease (CD) and ulcerative colitis (UC), and healthy controls were asked to complete a questionnaire on demographic data and smoking status. The questionnaire also included data on beliefs and awareness of smoking-related health effects, including effects on IBD. Results. A total of 139 IBD patients and 108 controls were enrolled in the study. Of the IBD patients, 17/139 (12.2%) were smokers compared to 18/108 (16.7%) of controls (p=0.3). Patients with IBD were nine times more likely to be everyday smokers than occasional smokers (OR=9.2, 95% CI: 1.9- 45.1, p=0.004). No difference was found between patients with CD and UC in their answers to the question of whether “smoking increases the risk for surgery in your type of IBD” (17/28 (60.7%) vs. 10/29 (34.5%), respectively (p=0.047). More patients with CD than UC were aware of the risks of smoking on their disease: extra-intestinal manifestations and disease exacerbation, OR=11.3 (95% CI: 4.1 – 30.9; p=0.000) and OR=19.3 (95% CI: 6.7 – 55.1; p=0.000), respectively. Conclusions. The data obtained demonstrated that adolescents with CD are much more aware of the role of smoking on CD than are their peers with UC; however, this awareness is still unsatisfactory. Therefore, there is an unmet need to implement better anti-smoking strategies for this group of patients.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 61-65
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Impact of the Nutritional State of Patients on the Results of the Surgical Treatment of Ulcerative Colitis
    Autorzy:
    Skowrońska-Piekarska, Urszula
    Matysiak, Konrad
    Sowińska, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1396201.pdf
    Data publikacji:
    2013-08-01
    Wydawca:
    Index Copernicus International
    Tematy:
    ulcerative colitis
    nutritional assessment
    undernutrition
    surgery
    length of stay
    Opis:
    A variety of mechanisms have been proposed to explain the malnutrition and body mass loss in UC patients. The aim of the study trial was a nutritional state assessment of 347 UC patients, admitted for surgical treatment, and the evaluation of the impact of this state on the postoperative course in this group of patients. Material and methods. We referred the results of nutritional state assessment to the length of time of postoperative hospitalization of patients. Results. Through application of the Kruskal-Wallis test we found statistically significant, but weakly expressed, differences between the values of nutritional state parameters and period of hospitalization of patients. The applied U Mann-Whitney test, with statistically significant results with p <0.05, showed statistically significant differences between cured and dead subgroups in: 1) loss of body mass in 6 months before hospitalization (p = 0.000033), 2) hemoglobin level (p = 0.006676), 3) total lymphocyte count (TLC) (p = 0.025242), 4) total serum protein level (p = 0.003485), 5) serum albumin level (p =0.00165). Differences in BMI values were statistically negligible (p = 0.969397). Conclusions. The body mass loss in 6 months before admission, total lymphocyte count and serum albumin level are the reference parameters of the nutritional state of UC patients on admission to surgery
    Źródło:
    Polish Journal of Surgery; 2013, 85, 8; 424-432
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inula viscosa phenolic extract suppresses colon cancer cell proliferation and ulcerative colitis by modulating oxidative stress biomarkers
    Autorzy:
    Kheyar, Naoual
    Bellik, Yuva
    Serra, Ana Teresa
    Kheyar, Farida
    Bedjou, Fatiha
    Powiązania:
    https://bibliotekanauki.pl/articles/16648114.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    Inula viscosa
    ulcerative colitis
    colorectal cancer
    anti-inflammatory
    antiproliferative
    Opis:
    Inula viscosa is a perennial herbaceous plant native to the Mediterranean Basin, which is used topically for the treatment of various diseases in folk medicine. This study aimed to evaluate the in vivo intestinal anti-inflammatory activity of the ethanolic extract of I. viscosa (EEIV) and to test its effect on a colorectal cancer cell line. EEIV was administered to rats orally and daily at 100 and 200 mg/kg body weight for 7 days, and then colitis was induced by intrarectal instillation of 2 ml of 4% (v/v) acetic acid (AA) solution. At the end of the experiment, clinical examinations of the rats were conducted by evaluating macroscopic and histological signs of colonic tissues and measuring erythrocyte sedimentation rate (ESR) and the levels of C-reactive protein, fibrinogen, myeloperoxidase (MPO), malondialdehyde (MDA) and nitric oxide (NO). Using MTS assay, the antiproliferative effect of EEIV against human colon carcinoma HT29 cells and cytotoxicity on nondifferentiated Caco-2 cell line was evaluated. EEIV significantly decreased the ESR and fibrinogen levels as compared to control colitic rats (P < 0.001). It also significantly decreased the NO, MDA, and MPO levels in the colon tissue compared with the untreated colitic group (P < 0.001). These results were confirmed by macroscopic and histological examination, which showed significant protection against AA-induced ulcerative colitis. Furthermore, EEIV at a concentration of 369.88 μg/ml did not show cytotoxicity on confluent Caco-2 cells, with significant inhibition of colorectal cancer cell (HT29) growth (EC50 = 62.39 μg/ml). These results demonstrate that EEIV plays a potential role as pharmacological tool in the management of inflammatory bowel disease and prevention of colorectal cancer.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2022, 103, 3; 269-284
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnosis and treatment difficulties in 18-year-old male patient with hereditary hemochromatosis, chronic hepatitis B, Gilbert syndrome and ulcerative colitis
    Autorzy:
    Sikorska, Katarzyna
    Liberek, Anna
    Romanowski, Tomasz
    Szlagatys-Sidorkiewicz, Agnieszka
    Landowski, Piotr
    Bielawski, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1039929.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    hereditary hemochromatosis
    ulcerative colitis
    chronic hepatitis B
    Glibert syndrome
    Opis:
    Among possible causes of chronic hepatitis in adolescents most common are infections, autoimmune disorders and metabolic diseases. Thus, diagnostic procedures should be multidirectional. This study reports diagnosis and treatment difficulties in an 18-year-old male patient with hereditary hemochromatosis (HH), ulcerative colitis (UC), chronic hepatitis B (CHB) and Gilbert syndrome. The presented case illustrates problems in diagnostics related to the presence of numerous disease conditions in one patient. It should be taken into consideration that these diseases coexisting in one patient can mutually affect their symptoms creating specific diagnostic difficulties.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 2; 251-254
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Multifocal colorectal cancer in ulcerative colitis patient with sclerosing cholangitis – case report
    Autorzy:
    Kosmowska, Anna
    Krokowicz, Piotr
    Nelke, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/1391810.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    adenocarcinoma
    multifocal colorectal cancer
    primary sclerosing cholangitis
    ulcerative colitis
    Opis:
    Introduction: U lcerative colitis (CU) is an inflammatory disease predisposing to colorectal cancer. Colorectal cancer in ulcerative colitis is more often metachronous or synchronous. Case report: In this case report we present a patient with multifocal colorectal cancer in the course of CU and operative treatment that was implemented. Additionallyprimary sclerosing cholangitis was diagnosed in this patient post-operatively.
    Źródło:
    Polish Journal of Surgery; 2020, 92, 6; 51-54
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Transcriptional changes between uninflamed ulcerative colitis and familial adenomatous polyposis pouch mucosa can be attributed to an altered immune response
    Autorzy:
    Paziewska, Agnieszka
    Horbacka, Karolina
    Goryca, Krzysztof
    Mikula, Michal
    Jarosz, Dorota
    Dabrowska, Michalina
    Krokowicz, Piotr
    Karon, Jacek
    Ostrowski, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1039136.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ulcerative colitis
    familial adenomatous polyposis
    pouch
    gene expression
    immune response
    Opis:
    A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and some patients with ulcerative colitis (UC). However, this surgical treatment is often associated with pouchitis, a long-term complication that occurs mostly in UC patients. The purpose of this study was to better define the molecular background of pouchitis. A microarray-based survey was performed using pouch mucosal samples collected from 28 and 8 patients undergoing surgery for UC and FAP, respectively. There were 4,770 genes that significantly differentiated uninflamed from inflamed mucosal samples, and their functional features were represented mostly by metabolic and cell proliferation pathways. In contrast, functional analyses of aberrantly expressed genes between UC and FAP samples, irrespective of mucosal inflammation status, revealed multiple pathways and terms that were linked to changes in immune response. Interestingly, the comparison of uninflamed UC and FAP samples identified a set of 29 altered probe sets, including an inflammation-related transcript encoding a Charcot-Leyden crystal (CLC) protein. The most distinct changes in gene expression profiles differentiating uninflamed UC and FAP pouch mucosal samples were attributed to the Gene Ontology category innate immune response. Our study confirmed that alterations in immune responses can be found between patients who underwent surgery for UC and FAP, independent of the pouch inflammation status. This observation may be important when managing IPAA patients.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 69-75
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    What Is “Inflammatory Bowel Disease” & How Can It Be Treated?
    Autorzy:
    Lustyk, Klaudia
    Sapa, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1034045.pdf
    Data publikacji:
    2013
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    Crohn’s disease
    Etiology
    Inflammatory bowel diseases
    Therapy
    Ulcerative colitis
    Opis:
    Ulcerative colitis and Crohn's disease are chronic diseases of the gastrointestinal tract, which are usually grouped together as inflammatory bowel disease (IBD). Despite many researches, the etiology is still unknown, but it is believed that IBD is caused by a combination of genetic and environmental factors that interact with the immunological system. Many people worldwide (around 4 million) suffer from a form IBD and the incidence of Crohn's disease is still increasing. Aminosalicylates, corticosteroids, immunomodulators, biologic medicines reduce the inflammation, relieve symptoms, prevent flare-ups, but new, more effective drugs with smaller amount of side effects are wanted and examined.
    Źródło:
    Medicina Internacia Revuo; 2013, 25, 100; 106- 111
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inflammatory bowel disease: clinical aspects
    Autorzy:
    Pasternak, Grzegorz
    Aebisher, David
    Filip, Rafał
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454879.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    inflammatory bowel diseases Leśniowski-Crohn’s disease ulcerative colitis
    mataloproteinases
    Opis:
    Introduction. Inflammatory bowel disease is a complex disease which arises as a result of an interaction between environmental and genetic factors leading to immunological responses and inflammation in the intestine. Aim. To review medical approaches used in inflammatory bowel disorders. Materials and methods. An analysis of literature regarding inflammatory bowel diseases, Leśniowski-Crohn’s disease, ulcerative colitis and mataloproteinases. Results. Current evidence suggests that patients with inflammatory bowel disease may have an elevated risk of endothelial dysfunction and coronary artery disease. Over the past two decades, great advances have been made in our understanding of the interplay between the inflammatory bowel disease. Conclusions. Inflammatory bowel diseases are increasing in Europe. The diagnosis is usually confirmed by biopsies on colonoscopy
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 341-345
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity
    Autorzy:
    Czub, Elzbieta
    Nowak, Jan
    Szaflarska-Poplawska, Anna
    Grzybowska-Chlebowczyk, Urszula
    Landowski, Piotr
    Moczko, Jerzy
    Adamczak, Daria
    Mankowski, Przemyslaw
    Banasiewicz, Tomasz
    Plawski, Andrzej
    Walkowiak, Jaroslaw
    Powiązania:
    https://bibliotekanauki.pl/articles/1039342.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    : pyruvate kinase
    calprotectin
    inflammatory bowel diseases
    ulcerative colitis
    Crohn's disease
    pediatrics
    Opis:
    Aims: Accurate assessment of inflammatory bowel disease (IBD) activity is the cornerstone of effective therapy. Fecal M2 isoform of pyruvate kinase (M2-PK) and fecal calprotectin (FC) are noninvasive markers of mucosal inflammation in IBD. The aim of this study was to compare performance of M2-PK and FC in assessment of pediatric ulcerative colitis (UC) and Crohn's disease (CD) severity and activity. Materials and methods: 121 patients with IBD, including 75 with UC and 46 with CD were recruited. Control group consisted of 35 healthy children (HS). Patients were assigned to groups depending on disease severity and activity. M2-PK and calprotectin concentration were determined in stool samples using ELISA. Areas under receiver operating characteristic curves (AUC) for FC and M2-PK with cut-off level at which M2-PK specificity was matching FC specificity were calculated and compared. Results: Performance of M2-PK at identifying patients with IBD, UC and CD among HS was inferior to FC. The differences in AUC were respectively: -0.10 (95% confidence interval [CI] [-0.13-(-0.06)], p<0.0001), -0.14 (95% CI [-0.19-(-0.09)], p<0.0001) and -0.03 (95% CI [-0.05-(-0.001)], p<0.02). M2-PK was inferior to FC in discriminating patients with mild UC from those with HS (AUC difference -0.23, 95% CI [-0.31-(-0.15)], p<0.0001). Conclusions: FC reflects pediatric IBD severity and activity better than M2-PK. This difference is particularly pronounced when identifying patients with mild UC and UC in remission.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 1; 99-102
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sexual activity in patients after proctocolectomy with ileal pouch-anal anastomosis
    Autorzy:
    Kluska, Piotr
    Dzika-Andrysiak, Katarzyna
    Mik, Michał
    Zelga, Piotr
    Włodarczyk, Marcin
    Kujawski, Ryszard
    Dziki, Łukasz
    Dziki, Adam
    Trzciński, Radzisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1391528.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    familial adenomatous polyposis
    quality of sexual life
    restorative proctocolectomy
    ulcerative colitis
    Opis:
    Introduction: Proctocolectomy with ileal pouch-anal anastomosis is the gold standard in the surgical treatment of patients with ulcerative colitis, familial adenomatous polyposis and other colorectal diseases requiring colectomy. The treatment consists in removing the large intestine and creating an intestinal reservoir from the last ileum loop and then anastomosing the intestinal reservoir with the anal canal. Like any surgical procedure, RPC-IPAA also carries the risk of complications, both early and late. Late postoperative complications include sexual dysfunction. Aim: The main goal of the following work is to assess the quality of life and sexual activity in patients having undergone the RPC-IPAA procedure at the General and Colorectal Surgery Clinic. Material and methods: The study group consisted of patients aged 19–79 who had been subjected to RPC-IPAA procedures at the General and Colorectal Surgery Clinic in years 2010–2019. The study was conducted on the basis of a survey consisting of 50 questions about the social and mental condition, medical history and previous treatment as well as the quality of sexual life before and after surgery. The scale used for the assessment of the quality of sex life consisted of 5 grades: very low, low, medium, high, very high. Thirty subjects (21 men and 9 women) took part in the survey. Ulcerative colitis (86.6%) was the most common reason for qualification for restorative proctectomy among the examined patients; less common reasons included familial adenomatous polyposis (13.3%) and synchronous colorectal cancer (3.3%). A vast majority of the surgeries had been performed after 10 years’ duration of ulcerative colitis, and the intestinal reservoir had been functioning for over a year at the time of the examination. In addition, the effect of taking steroids and the impact of early postoperative complications on the quality of sex life of patients was assessed. Results: High or very high sexual activity before surgery was reported by 46% of patients whereas low or very low quality was reported by 13%. The rest of the responders assessed their pre-operative sexual activity as average. After surgery, 23% of patients rated their sexual activity as high or very high while 36.6% of patients rated it as low or very low (P = 0.07). It was also noted that taking corticosteroids before surgery decreased the quality of sex life after surgery (P = 0.07 for activity, P = 0.04 for quality). None of the women surveyed used artificial moisturizing of intimate places during sex. Only 1 person stated that they started using artificial moisturization of intimate places after the procedure (P = 0.5). None of the men surveyed had used pharmacological agents to help them obtain an erection before surgery while as many as 33% of responders reported the need for their use after surgery (P = 0.008). Other postoperative sexual dysfunctions were also registered, such as dyspareunia (13.3%), sensory disorder within the intimate region, fecal incontinence, and urinary incontinence. Conclusions: To sum up, sexual activity and quality of sexual life deteriorated after RPC-IPAA in our patients.
    Źródło:
    Polish Journal of Surgery; 2021, 93, 1; 19-24
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sleep disturbance and disease activity in adult patients with inflammatory bowel diseases
    Autorzy:
    Sobolewska-Wlodarczyk, A.
    Wlodarczyk, M.
    Banasik, J.
    Gasiorowska, A.
    Wisniewska-Jarosinska, M.
    Fichna, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/70043.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    sleep disturbance
    inflammatory bowel disease
    Crohn's disease
    ulcerative colitis
    disease activity
    inflammatory disease
    patient
    Źródło:
    Journal of Physiology and Pharmacology; 2018, 69, 3
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Retrospective analysis of hospital admissions of patients with ulcerative colitis and Crohns disease from semi-rural and rural regions in the Department of Gastroenterology in Lublin between 2000-2006
    Autorzy:
    Skrzydlo-Radomanska, B
    Radwan, P.
    Radwan-Kwiatek, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/49439.pdf
    Data publikacji:
    2008
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    rural region
    ulcerative colitis
    Crohn's disease
    retrospective analysis
    human disease
    hospital
    patient
    inflammatory bowel disease
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2008, 15, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts
    Autorzy:
    Liberek, Anna
    Kmieć, Zbigniew
    Wierzbicki, Piotr
    Jakóbkiewicz-Banecka, Joanna
    Liberek, Tomasz
    Łuczak, Grażyna
    Plata-Nazar, Katarzyna
    Słomińska-Frączek, Magdalena
    Kaszubowska, Lucyna
    Gabig-Cimińska, Magdalena
    Węgrzyn, Alicja
    Powiązania:
    https://bibliotekanauki.pl/articles/1039466.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Crohn's disease
    ulcerative colitis
    Transforming Growth Factor-β1
    longitudinal assessment of TGF-β1 level
    Opis:
    Previously published studies on levels of the transforming growth factor-β1 (TGF-β1) protein and mRNA of the corresponding gene in patients suffering from inflammatory bowel diseases (IBD) gave varying results, leading to contradictory conclusions. To solve the contradictions, we aimed to assess longitudinally TGF-β1 protein and mRNA levels at different stages of the disease in children suffering from IBD. The study group consisted of 19 pediatric patients with IBD at the age between 3.5 and 18.4 years. The control group consisted of 42 children aged between 2.0 and 18.0 years. The plasma TGF-β1 concentration was measured with ELISA. mRNA levels of the TGF-β1 gene isolated from samples of the intestinal tissue were assessed by reverse transcription and real-time PCR. Levels of TGF-β1 protein in plasma and corresponding mRNA in intestinal tissue were significantly higher in IBD patients than in controls. TGF-β1 and corresponding transcripts were also more abundant in plasma and intestinal tissue, respectively, in patients at the active stage of the disease than during remission. In every single IBD patient, plasma TGF-β1 level and mRNA level in intestinal tissue was higher at the active stage of the disease than during remission. Levels of TGF-β1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of IBD.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 4; 683-688
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Probiotics in the treatment of gastrointestinal diseases
    Autorzy:
    Przerwa, F.
    Kukowka, A.
    Kotrych, K.
    Uzar, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/2049330.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    gastrointestinal disease
    irritable bowel syndrome
    gastroesophageal reflux
    peptic ulcer disease
    ulcerative colitis
    treatment
    microbiota
    probiotic
    probiotyki
    choroby układu pokarmowego
    mikrobiota
    Opis:
    The human microbiota has a tremendous effect on our health. In the last decades, our knowledge about interactions between bacteria and humans have grown greatly. Not only is it necessary for humans to synthesize vitamins, to have tight intestinal barriers or protect from pathogens, it also has an impact on our immune system and thus plays an important role in autoimmune diseases and prevention of excessive inflammatory response. The idea of probiotics is to restore the balance in humans digestive microbiota. There is a growing number of scientific papers that proves a positive impact of using probiotics in various diseases. However, there are still questions that need to be answered before probiotics play a bigger role in the treatment. This paper presents the information about the use of probiotics in most common diseases of gastrointestinal tract.
    Źródło:
    Herba Polonica; 2021, 67, 2; 39-48
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Podstawowe objawy i różnicowanie nieswoistych chorób zapalnych jelit
    Basic symptoms and differentiation of inflammatory bowel diseases
    Autorzy:
    Wojtuń, Stanisław
    Gil, Jerzy
    Szwed, Łukasz
    Dyrla, Przemysław
    Powiązania:
    https://bibliotekanauki.pl/articles/1033264.pdf
    Data publikacji:
    2014
    Wydawca:
    Medical Communications
    Tematy:
    Crohn’s disease
    endoscopy
    gastrointestinal diseases
    treatment
    ulcerative colitis
    choroby przewodu pokarmowego
    choroba leśniowskiego-crohna
    wrzodziejące zapalenie jelita
    grubego
    endoskopia
    leczenie
    Opis:
    Ulcerative colitis (colitis ulcerosa, CU) and Crohn’s disease belong to a group of nonspecific inflammatory bowel diseases characterized by chronicity and unknown aetiology. Due to their heterogeneous pathogeneses, their clinical pictures and clinical courses vary. This results in diagnostic difficulties that are encountered despite the availability of a number of specialized tests in contemporary medicine. It is known that a condition necessary to establish a definitive diagnosis is to confirm the presence of a nonspecific inflammatory bowel disease in a histopathological examination, but laboratory tests are helpful in the initial diagnosis and demonstrate the extent and severity of the inflammatory process. C-reactive protein is the indicator of the inflammatory process, and anaemia that occurs in ulcerative colitis is due to both the chronicity of the disease and iron deficiency secondary to blood loss. Laboratory diagnosis is also applicable in the evaluation of parenteral complications concerning the liver, bile ducts, and osteoporosis. Abnormal liver function tests are frequent in inflammatory bowel diseases and may be caused by an ongoing inflammatory process typical of these diseases as well as by the pharmacological treatment implemented. Although new methods, such as computed tomography, magnetic resonance imaging and positron emission tomography, are used in diagnosing gastrointestinal diseases, endoscopy with histopathological analysis of the collected samples still is (and will be for a long time) a primary diagnostic method in the process of diagnosing, monitoring the course of treatment and oncological surveillance.
    Wrzodziejące zapalenie jelita grubego i choroba Leśniowskiego-Crohna należą do grupy nieswoistych chorób zapalnych jelit o przewlekłym przebiegu i nieznanej etiologii. Z uwagi na niejednorodną patogenezę mają zróżnicowany obraz i przebieg kliniczny, co powoduje trudności diagnostyczne pomimo dostępności wielu wielospecjalistycznych badań. Wiadomo, że warunkiem koniecznym ustalenia ostatecznego rozpoznania jest potwierdzenie nieswoistej choroby zapalnej jelit w badaniu endoskopowym i histopatologicznym, niemniej jednak badania laboratoryjne są pomocne we wstępnej diagnostyce i odzwierciedlają zasięg oraz nasilenie procesu zapalnego. Białko C-reaktywne stanowi wykładnik procesu zapalnego, a występująca we wrzodziejącym zapaleniu jelita grubego niedokrwistość jest wynikiem zarówno przewlekłości choroby, jak i niedoboru żelaza wtórnego do utraty krwi. Diagnostyka laboratoryjna ma również zastosowanie w ocenie powikłań pozajelitowych dotyczących wątroby i dróg żółciowych, a także osteoporozy. Nieprawidłowe wyniki prób wątrobowych są częste w chorobach zapalnych jelit i mogą być spowodowane procesem zapalnym typowym dla tych chorób, ale też stosowanym leczeniem farmakologicznym. Chociaż powstają nowe metody wykorzystywane w diagnostyce przewodu pokarmowego, takie jak tomografia komputerowa, rezonans magnetyczny, pozytronowa tomografia emisyjna, to jednak badanie endoskopowe z oceną histopatologiczną pobranych wycinków jest (i jeszcze długo będzie) podstawową metodą diagnostyczną w rozpoznawaniu, monitorowaniu leczenia oraz nadzorze onkologicznym.
    Źródło:
    Pediatria i Medycyna Rodzinna; 2014, 10, 1; 61-66
    1734-1531
    2451-0742
    Pojawia się w:
    Pediatria i Medycyna Rodzinna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oligonol prevented the relapse of dextran sulfate sodium-ulcerative colitis through enhancing Nrf2-mediated antioxidative defense mechanism
    Autorzy:
    Kim, K.-J.
    Park, J.-M.
    Lee, J.-S.
    Kim, Y.S.
    Kangwan, N.
    Han, Y.-M.
    Kang, E.A.
    An, J.M.
    Park, Y.K.
    Hahm, K.-B.
    Powiązania:
    https://bibliotekanauki.pl/articles/69501.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    ulcerative colitis
    inflammatory bowel disease
    oxidative stress
    oligonol
    polyphenol
    adaptive response
    quinone oxidoreductase
    relapse
    nuclear factor-kappaB
    tumour necrosis factor-alpha
    Źródło:
    Journal of Physiology and Pharmacology; 2018, 69, 3
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The therapeutic potential of short-chain fatty acids enemas in inflammatory bowel diseases: a systematic review
    Potencjał terapeutyczny krótkołańcuchowych kwasów tłuszczowych podawanych doodbytniczo w nieswoistych chorobach zapalnych jelit: przegląd systematyczny
    Autorzy:
    Kaczmarek, Nina
    Kokot, Marta
    Makarewicz, Aleksandra
    Glapa-Nowak, Aleksandra
    Nowak, Jan K.
    Jamka, Małgorzata
    Walkowiak, Jarosław
    Powiązania:
    https://bibliotekanauki.pl/articles/762653.pdf
    Data publikacji:
    2020-07-21
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    choroba Leśniowskiego-Crohna
    nieswoiste choroby zapalne jelit
    krótkołańcuchowe kwasy tłuszczowe
    wrzodziejące zapalenie jelita grubego
    roztwór doodbytniczy
    inflammatory bowel diseases
    Crohn’s disease
    ulcerative colitis
    enema
    short-chain fatty acid
    Opis:
    Sugeruje się, że krótkołańcuchowe kwasy tłuszczowe (SCFA) mogą redukować nasilenie objawów klinicznych, poprawiać wyniki badania endoskopowego i histopatologicznego u pacjentów z nieswoistymi chorobami zapalnymi jelit (IBD). Jednakże, pomimo obiecujących badań in vitro, wyniki badań przeprowadzonych w modelu zwierzęcym oraz randomizowanych badań kontrolowanych (RCT) są niejednoznaczne. Celem tego przeglądu systematycznego była ocena skuteczności SCFA podawanych doodbytniczo u pacjentów z IBD. Wyszukiwanie elektroniczne przeprowadzono w następujących bazach danych: PubMed, Scopus, Web of Science i Cochrane. Kryteria włączenia badań oryginalnych do przeglądu systematycznego obejmowały: 1) rodzaj badań: równoległe lub krzyżowe RCT; 2) język: artykuły w języku angielskim; 3) rodzaj interwencji: SCFA podawane doodbytniczo; 4) populacja badana: pacjenci z wrzodziejącym zapaleniem jelita grubego lub chorobą Leśniowskiego-Crohna, niezależnie od płci, wieku, pochodzenia etnicznego, lokalizacji badania i wielkości próby. Jako punkty końcowe przyjęto wpływ podaży SCFA na wskaźnik aktywności choroby (DAI) oraz wyniki badań endoskopowych i histopatologicznych. Do analizy zakwalifikowano 4 badania obejmujące łącznie 187 pacjentów z IBD. W 2 badaniach oceniano wpływ SCFA na DAI, w 4 badaniach – na wyniki badania endoskopowego i histopatologicznego. Nie stwierdzono istotnych różnic pomiędzy grupą interwencyjną a grupą kontrolną w zakresie wpływu na jakikolwiek analizowany parametr. W 2 badaniach wykazano istotny spadek DAI po okresie interwencji, zarówno w grupie SCFA, jak i w grupie kontrolnej. Podobnie, w 4 badaniach odnotowano statystycznie istotne różnice między wynikami endoskopowymi przed i po interwencji w grupie SCFA. Jednakże, w 3 badaniach podobny efekt zaobserwowano w grupie kontrolnej. Poza tym, w 3 badaniach nie zaobserwowano wpływu SCFA na wyniki histopatologiczne. Podsumowując, brak jest dowodów na skuteczność SCFA podawanych doodbytniczo u pacjentów z IBD.
    It has been suggested that short-chain fatty acid (SCFA) enemas might improve clinical, endoscopic and histological scores in patients with inflammatory bowel disease. However, despite the promising results of in vitro studies, the findings of animal studies and randomised controlled trials are inconclusive. Therefore, this review aimed to assess the efficacy of SCFA enemas in patients with inflammatory bowel diseases. Electronic searches were performed in PubMed, Scopus, Web of Science and Cochrane databases. Original studies were included in this systematic review if they met the following inclusion criteria: 1) types of studies: parallel or crossover randomised controlled trials; 2) language: articles published in English; 3) types of interventions: SCFA enemas; 4) population: studies conducted in subjects with ulcerative colitis or Crohn’s disease of either gender and any age and without restrictions based on the ethnicity of study participants, location of study or sample size. The outcomes included the effect of SCFA enemas on disease activity index (DAI), endoscopic and histological scores. In total, four studies enrolling 187 patients with inflammatory bowel diseases were included in this systematic review. Two studies assessed the effect of SCFA enemas on DAI. Four studies evaluated the effect of SCFA therapy on the endoscopic score and the histological score. There were no significant differences between the SCFA groups and the control groups regarding the impact on any analysed parameter. Two studies demonstrated a statistically significant decrease in DAI after the intervention period, both in the SCFA groups and the control groups. Similarly, statistically significant differences between pre- and post-intervention endoscopic scores in the SCFA groups were reported in four studies. However, in three studies, a similar effect was demonstrated in the control groups. Besides, in three studies no effect of SCFA enemas on the histological score was observed. In conclusion, there is no evidence for the effectiveness of SCFA enemas in patients with inflammatory bowel diseases.
    Źródło:
    Farmacja Polska; 2020, 76, 5; 297-304
    0014-8261
    2544-8552
    Pojawia się w:
    Farmacja Polska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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