Skocz do pozycji: 1.

Tytuł:

Tuberculosis of gall-bladder mimicking malignancy – a case report

Autorzy:

Dahiya, Divya
Kaman, Lileswar
Rajendran, Jayapal
Garg, Mandeep

Powiązania:

https://bibliotekanauki.pl/articles/1393918.pdf

Data publikacji:

2016

Wydawca:

Index Copernicus International

Tematy:

gall-bladder tuberculosis
gall-bladder cancer
hepatobiliary tuberculosis
tuberculosis

Opis:

A correct preoperative diagnosis of gall-bladder tuberculosis is exceptionally unusual in the absence of pathognomic features both on clinical presentation and on imaging. Herein we present a case of 50 year female who was operated with a provisional diagnosis of gall-bladder malignancy and was found to have tuberculosis of gall-bladder on histopathology

Źródło:

Polish Journal of Surgery; 2016, 88, 5; 504-509
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:

Incidence of tuberculosis in the Tatras region

Autorzy:

Gulášová, Ivica
Gornerová, Lenka
Breza jr., Ján
Breza, Ján

Powiązania:

https://bibliotekanauki.pl/articles/2157018.pdf

Data publikacji:

2014

Wydawca:

Instytut Studiów Międzynarodowych i Edukacji Humanum

Tematy:

pulmonary tuberculosis
extrapulmonary tuberculosis
epidemiological situation
region
vaccination

Opis:

The authors point out that tuberculosis is the oldest infectious killer of humans and today it is such a serious threat to health that the World Health Organization (WHO) equates it to a time bomb. The most common source of infection by mycobacteria tuberculosis to a man is a sick person. Epidemiologically greatest danger is sick person with untreated decay pulmonary tuberculosis whose sputum may spread billions of tuberculosis bacilli every day. The overall situation in the incidence of tuberculosis (TB) in Slovakia is generally favorable, although in the eastern parts of Slovakia incidence is growing rapidly. Slovakia has compared with all Europe small to moderate incidence of this disease and its incidence has downward trend. East Slovakia so far has hot won combat this disease yet. It is therefore necessary to continue effective intervention and prevention to combat the spread of this disease.

Źródło:

Społeczeństwo i Edukacja. Międzynarodowe Studia Humanistyczne; 2014, 2(14); 163-170
1898-0171

Pojawia się w:

Społeczeństwo i Edukacja. Międzynarodowe Studia Humanistyczne

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 3.

Tytuł:

Surgical Management of Genitourinary Tuberculosis: our Experience and review of literature

Autorzy:

Mittal, Ankur
Ranjan, Satish
Narain, Tushar
Panwar, Vikas

Powiązania:

https://bibliotekanauki.pl/articles/1391814.pdf

Data publikacji:

2020

Wydawca:

Index Copernicus International

Tematy:

antitubercular treatment (ATT)
extrapulmonary tuberculosis (EPTB)
genitourinary system (GUS)
genitourinary tuberculosis (GUTB)
tuberculosis (TB)

Opis:

Background: Genitourinary tuberculosis is one of the most common forms of extra-pulmonary tuberculosis. Owing to a myriad of clinical presentations and discrepancies in the diagnostic modalities, patients usually present late, which results in a high number of them requiring surgical intervention. The present study aims to retrospectively analyze the role of surgery in genitourinary tuberculosis. Patients and method: All patients diagnosed with genitourinary tuberculosis at our centre between October 2017 and September 2019 were included in the study. The mode of presentation, duration of symptoms, investigations performed, treatment received, and follow-up were studied. Results: Out of 25 patients diagnosed with genitourinary tuberculosis (GUTB), there were 15 (60%) males and 10 (40%) females. The mean age of presentation was 40.84 years. Nineteen (76%) patients underwent surgical intervention, and many patients required more than one surgical procedure. A reconstructive procedure was carried out in seven patients. At a median follow-up of 12 months, all patients did well, showing no relapse. Conclusion: Surgery, along with antitubercular treatment, is the key to the management of GUTB presenting with structural damage. However, surgery can be ablative or reconstructive, depending on various factors discussed in the present study. This preserves or restores the optimal function of the genitourinary system affected by the mycobacterium bacilli.

Źródło:

Polish Journal of Surgery; 2020, 92, 6; 1-6
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:

Extrapulmonary tuberculosis: An overview on infection beyond Lungs

Autorzy:

Khusro, Ameer
Aarti, Chirom

Powiązania:

https://bibliotekanauki.pl/articles/1031696.pdf

Data publikacji:

2020

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

Clinical monitoring
Extrapulmonary tuberculosis
Organs
Tissues
Tuberculosis

Opis:

Extrapulmonary tuberculosis (EPTB) involves 10-15% of all tuberculosis (TB) cases. Recent statistical report showed that EPTB accounts for more than 50% of all cases of TB in HIV-positive patients. In spite of existing anti-tubercular drugs based treatment of EPTB, the ideal regimen and duration of treatment have not yet been established. In general, EPTB is a kind of TB infecting diversified tissues and organs of body other than lungs. In fact, people suffering from TB and co-infected with HIV are prone to develop EPTB much more frequently. The present chapter discusses on the general overviews of EPTB infecting distinct body sites other than lungs. Currently, the treatment of EPTB completely relies on existing anti-tubercular drugs. In addition, significant efforts, particularly close clinical monitoring would be an imperative step towards its therapeutic strategy.

Źródło:

World News of Natural Sciences; 2020, 28; 131-141
2543-5426

Pojawia się w:

World News of Natural Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 5.

Tytuł:

Standards of Tuberculosis care: An Indian perspective

Autorzy:

Shrivastava, SR.
Shrivastava, PS.
Ramasamy, J.

Powiązania:

https://bibliotekanauki.pl/articles/1914051.pdf

Data publikacji:

2014

Wydawca:

Uniwersytet Medyczny w Białymstoku

Tematy:

Tuberculosis
International standards for Tuberculosis care
India

Opis:

Tuberculosis (TB) is a social disease with medical aspects accounting for 8.7 million new cases and 1.4 million deaths in the year 2011 worldwide. International standards for TB care (ISTC) were formulated to develop uniform guidelines for ensuring the delivery of a widely accepted level of care by all health care practitioners in managing TB patients, or those suspected to have tuberculosis. India alone has contributed 25% of the globally reported new cases of TB in 2011 and is also the leading nation in accounting for drug resistant TB (DR-TB). Thus to develop uniform standards of TB care and to engage private sector which caters to more than 70% of TB patients, the “central TB division” has developed standards of TB care in India (STCI). These local standards have been designed after taking into account the guidelines of the World Health Organization and ISTC disease control STCI has proposed 26 standards (viz. diagnosis – 1 to 6; treatment – 7 to 11; public health – 12 to 21; social inclusion – 22 to 26) for effective prevention and control of TB. To conclude, the Indian standards of TB care have been proposed to emphasize on individual patient care and public health principles of disease control for ultimately reducing not only the suffering but also the economic losses from tuberculosis.

Źródło:

Progress in Health Sciences; 2014, 4, 1; 280-282
2083-1617

Pojawia się w:

Progress in Health Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:

The role of BCG in prevention of tuberculosis and the strategies to improve its immunogenicity
Rola BCG w zapobieganiu gruźlicy i strategie prowadzące do zwiększenia jej immunogenności

Autorzy:

Mazurek, Jolanta

Powiązania:

https://bibliotekanauki.pl/articles/2097704.pdf

Data publikacji:

2018-06-22

Wydawca:

Państwowa Wyższa Szkoła Zawodowa w Tarnowie

Tematy:

gruźlica
szczepionka
BCG
Mycobacterium tuberculosis
tuberculosis
vaccine

Opis:

Tuberculosis (TB) remains a major public health problem and the main cause of death from the infectious diseases worldwide. Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis, is the oldest known human pathogen. The only available TB vaccine, BCG, was first administered in 1921 and since then remains the only protecting tool against TB. Yet, its efficacy is limited and there is an urgent need to design and produce a novel vaccine that will protect against this deadly disease in the era of emerging problems with antibiotic resistance. In this review a current, global TB situation is outlined and the characteristics of BCG are presented. Finally, the strategies leading to generation of BCG variants providing improved protecting efficacy are shortly described.
Gruźlica pozostaje ważnym problemem zdrowia publicznego i jest główną przyczyną zgonów z powodu chorób zakaźnych na całym świecie. Mycobacterium tuberculosis (Mtb), bakteria wywołująca gruźlicę, jest najstarszym znanym ludzkim patogenem. Jedyną dostępną szczepionkę przeciwgruźliczą, BCG, po raz pierwszy zastosowano już w 1921 r. i od tego czasu pozostaje ona jedynym narzędziem zapobiegającym gruźlicy. Jej skuteczność jest jednak ograniczona i istnieje pilna potrzeba zaprojektowania i wyprodukowania nowej szczepionki, która chroni przed tą śmiercionośną chorobą, szczególnie w dobie pojawiających się problemów z antybiotykoopornością Mtb. W niniejszej pracy przeglądowej opisano aktualną, globalną sytuację epidemiologiczną dotyczącą gruźlicy i przedstawiono charakterystykę BCG. Opisano także strategie prowadzące do wytworzenia wariantów BCG zapewniających lepszą ochronę przeciwgruźliczą.

Źródło:

Health Promotion & Physical Activity; 2018, 2, 1; 17-22
2544-9117

Pojawia się w:

Health Promotion & Physical Activity

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:

Gruźlica – od diagnostyki do leczenia według standardów dla krajów Unii Europejskiej
Tuberculosis – from diagnosing to treatment according to the European Union standards

Autorzy:

Grzelewska-Rzymowska, Iwona
Mańkowska-Baczyńska, Katarzyna
Górski, Paweł

Powiązania:

https://bibliotekanauki.pl/articles/1032967.pdf

Data publikacji:

2013

Wydawca:

Medical Communications

Tematy:

IGRA tests
Mycobacterium tuberculosis
antituberculosis drugs
latent tuberculosis
tuberculosis
gruźlica
mycobacterium tuberculosis
leki przeciwprątkowe
gruźlica utajona
testy igra

Opis:

In the article the authors presented the epidemiological data referring to tuberculosis in some countries and in Poland. Tuberculosis continues to be a priority challenge for public health. The present chemotherapy for tuberculosis is very efficacious but has the disadvantages of being lengthy and complex. The serious problems remain drug-resistant strains of Mycobacterium tuberculosis, especially multi-drug MDR-TB and extensively-drug resistant XRD-TB as well as the prevalence of HIV co-infection among tuberculosis cases. In October, 2011 the European Union Standards for Tuberculosis Care (ESTC) were finalized. This document is consistent with WHO definitions and recommendations. ESTC consists of four sections – diagnosis, treatment, HIV and comorbidities and public health, which correspond to the International Standards for Tuberculosis Care (ISTC) from 2009. In 2013, the Polish recommendations for tuberculosis were published. The authors of this paper comment on all recommendations referring to tuberculosis. Clinical symptoms of tuberculosis and some problems connected with latent tuberculosis are presented. All sputum specimens and other samples should be submitted for microscopic, culture and drug susceptibility tests. WHO recommends rapid molecular assay, which should be performed on the day of microbiological diagnosis of tuberculosis. All patients, including those with HIV infection, who have not been previously treated and without any risk factors for drug resistance, should receive isoniazid, rifampicin, pyrazinamide and ethambutol for two months and isoniazid and rifampicin for four months. Some standards are devoted to children tuberculosis. Infection evoked by Mycobacterium tuberculosis should be elicited using tuberculin skin test and/or interferon gamma release assay (IGRA test). Children under 5 years of age and patients with HIV infection should be treated for latent tuberculosis infection with isoniazid when they do not have active tuberculosis.
Autorzy przedstawiają dane epidemiologiczne odnoszące się do gruźlicy w niektórych krajach, w tym w Polsce. Gruźlica ciągle pozostaje priorytetowym wyzwaniem dla zdrowia publicznego. Obecnie stosowana chemioterapia jest skuteczna, ale długotrwała i kompleksowa. Poważny problem stanowią szczepy Mycobacterium tuberculosis oporne na leki przeciwprątkowe, szczególnie szczepy oporne na wiele leków (MDR-TB) i te o rozszerzonej oporności (XDR-TB), oraz zakażenia HIV wśród chorych na gruźlicę. W październiku 2011 roku zostały sfinalizowane standardy dotyczące gruźlicy dla krajów Unii Europejskiej (European Union Standards for Tuberculosis Care, ESTC). Dokument ten pozostaje w zgodzie z definicjami i rekomendacjami WHO. ESTC składają się z czterech sekcji: diagnozowanie, leczenie, HIV i choroby współistniejące, zdrowie publiczne, które korespondują z Międzynarodowymi Standardami Opieki nad Chorymi na Gruźlicę (ISTC) z 2009 roku. W 2013 roku zostały opublikowane polskie rekomendacje. Autorzy komentują wszystkie odnoszące się do gruźlicy rekomendacje. Przedstawiono objawy kliniczne gruźlicy i wybrane problemy gruźlicy utajonej (latent tuberculosis). Próbki wydzieliny oskrzelowej powinny być poddane badaniu mikroskopowemu, hodowli i testom lekowraźliwości. WHO rekomenduje szybki test molekularny, który należy wykonać w dniu bakteriologicznej diagnozy gruźlicy. Wszyscy chorzy (w tym osoby zakażone HIV), którzy nie byli wcześniej leczeni i u których nie występują czynniki ryzyka oporności na leki, powinni otrzymywać przez 2 miesiące izoniazyd, ryfampicynę, pirazynamid i etambutol, a przez 4 miesiące izoniazyd i ryfampicynę. Niektóre standardy odnoszą się do gruźlicy dziecięcej. Infekcja wywołana przez Mycobacterium tuberculosis powinna zostać wykryta za pomocą testu tuberkulinowego lub testu uwalniania interferonu gamma (IGRA). Dzieci poniżej 5. roku życia i osoby zakażone HIV, u których stwierdzono gruźlicę utajoną, należy leczyć izoniazydem, jeśli nie stwierdza się u nich aktywnej gruźlicy.

Źródło:

Pediatria i Medycyna Rodzinna; 2013, 9, 3; 224-231
1734-1531
2451-0742

Pojawia się w:

Pediatria i Medycyna Rodzinna

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:

Treatment for active tuberculosis in giraffe (Giraffa camelopardalis) in a Zoo and potential consequences for public health - case report

Autorzy:

Krajewska-Wędzina, M.
Augustynowicz-Kopeć, E.
Weiner, M.
Szulowski, K.

Powiązania:

https://bibliotekanauki.pl/articles/2081930.pdf

Data publikacji:

2018

Wydawca:

Instytut Medycyny Wsi

Tematy:

tuberculosis
epidemiology
anti-tuberculosis therapy
public health
giraffe

Opis:

Introduction. Bovine tuberculosis (bTB) is an infectious disease that occurs in many species of both domestic and freeranging animals, as well as animals kept in zoos. According to the Polish regulations, cattle tuberculosis are slaughtered and microbiological examinations are performed, the rest of animal species can be treated and laboratory diagnostics are not obligatory. Case report. The presented case concerns two male giraffes which were purchased by the zoo and united with a third male. After a year, the oldest male died. Post mortem examinations confirmed generalized tuberculosis. After a further six months, the second male was euthanized after suffering great pain. The material for the study of drug resistance was a swab from the nose, obtained ante mortem from the third male. Attempted treatments did not produce the expected results. Genotyping allowed the exclusion of a common source of transmission. Conclusions. The final effect of the anti-tuberculosis therapy in the male giraffe raises the question whether the research team should have undertaken the treatment of the animal with active tuberculosis.

Źródło:

Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 593-595
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:

Multi Drug Resistant Tuberculosis

Autorzy:

Zacharia, Balaji
Roy, Antony

Powiązania:

https://bibliotekanauki.pl/articles/454987.pdf

Data publikacji:

2019

Wydawca:

Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego

Tematy:

BACTEC
MDRTB
multi drug resistant tuberculosis Mycobacterium
tuberculosis

Opis:

Introduction. Tuberculosis is one of the oldest infections known to mankind. Of all infectious diseases, tuberculosis causes the most fatalities of any infection. The incidence of tuberculosis on the rise due to the increased prevalence of HIV infection. The incidence of drug resistance strains of mycobacterium is also on the rise. When the mycobacterium is resistant to both INH and rifampicin it is called multi drug resistant tuberculosis. There is a primary and an acquired type of drug resistance. Multidrug resistant tuberculosis is a not only a problem for the patient but also for society at large. The treatment of multidrug resistant tuberculosis requires an entirely different approach. Aim. In this review, we are going to describe the etiopathogenesis, diagnosis, investigations and treatment of multi drug resistant tuberculosis. Material and methods. Analysis of the current literature. Results. Genetic factors, previous treatment, and other factors predisposes the onset of drug resistance. By early detection and prevention of spread of drug resistant strains we can prevent the spread of resistant strains. Conclusion. Drug resistance in tuberculosis is a very complex and dangerous problem. We have to prevent the development and spread of MDRTB. Good quality drugs should be used and made available to all sections of the population. Enhancing the National tuberculosis programs is the best way to attain an effective way to control this menace.

Źródło:

European Journal of Clinical and Experimental Medicine; 2019, 3; 262-269
2544-2406
2544-1361

Pojawia się w:

European Journal of Clinical and Experimental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:

Strengthening infrastructure in management of drug resistant tuberculosis in India

Autorzy:

Shrivastava, SR.
Shrivastava, PS.
Ramasamy, J.

Powiązania:

https://bibliotekanauki.pl/articles/1914046.pdf

Data publikacji:

2014

Wydawca:

Uniwersytet Medyczny w Białymstoku

Tematy:

tuberculosis
Revised National Tuberculosis Control Program
multi-drug resistant
India

Opis:

The emergence of resistance to first-line drugs used to treat tuberculosis (TB) has become a significant public health concern and an obstacle in implementation of effective TB control activities globally. In India, Revised National TB Control Program (RNTCP) introduced the programmatic management of drug-resistant TB (PMDT) services to address the needs of MDR-TB patients. To execute the plan with perfection, RNTCP has devised MDR suspect criteria – A, B, and C so that gradually PMDT services can be extended to the whole country. These criteria were framed to run in tandem with the strengthening of the laboratory services so that the existing certified laboratories can carry out the culture and DST services without being overburdened. Altogether, RNTCP is committed for the strengthening and capacity building of its resources to offer culture and DST services right at the time of diagnosis.

Źródło:

Progress in Health Sciences; 2014, 4, 1; 277-279
2083-1617

Pojawia się w:

Progress in Health Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 11.

Tytuł:

Antimycobacterial activity of ethanolic extract of Artemisia absinthium L.

Autorzy:

Hojageldiyev, T.
Bolmammedov, Y.
Gurbanaliyev, S.

Powiązania:

https://bibliotekanauki.pl/articles/1075710.pdf

Data publikacji:

2019

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

Artemisia absinthium
Mycobacteria tuberculosis
Mycobacterium tuberculosis
antimycobacterial
ethanolic extract

Opis:

It is known that, drugs used in the treatment of tuberculosis show toxic effect to organism especially to liver beside its therapeutic effect. Because of ineffectiveness of drugs used in the treatment regimen of tuberculosis against multidrug resistance (MDR) and extensively drug-resistance (XDR) tuberculosis requires the development of new treatment methods and new novel drugs. Considering the usage of Artemisia absinthium in traditional medicine in treatment of wounds which suggests its antibacterial activity it seems that, also it may have significant antimycobacterial activity. The objective of present study was to evaluate antibacterial activity of ethanolic extract of A. absinthium against M. tuberculosis. In this study, the effect of ethanolic extract of A. absinthium was tested against tuberculosis and pharmaco-toxicological properties evaluated on laboratory animals. The 20%, 40%, 70% and 96% ethanolic extracts of A. absinthium prepared then its bacteriostatic and bactericidal activities were evaluated by validated methods. Data were analyzed by GraphPad Prism 7.0 at the level P<0.05. Results showed that ethanolic extracts of A. absinthium show no toxicological properties with having high LD50. All concentrations of extract show high bacteriostatic activity on M. tuberculosis. 96% ethanolic extract has highest bactericidal effect among other concentrations. By conducting further studies, as a results of our study, antimycobacterial drug can be prepared from A. absinthium.

Źródło:

World Scientific News; 2019, 119; 224-230
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:

Cervical lymphadenitis as a result of (Hijab) pin prick in north of Jordan

Autorzy:

Gharaibeh, Mahmoud M.
Al Wadiya, Ahmed
Gharaibeh, Ahmad

Powiązania:

https://bibliotekanauki.pl/articles/2040135.pdf

Data publikacji:

2020-12-30

Wydawca:

Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego

Tematy:

Hijab
lymphadenitis
tuberculosis

Opis:

Introduction. Cervical lymph nodes are lymph nodes found in the neck. Hijab is a head cover worn by some Muslim women in the presence of any adult male outside of their immediate family, which usually covers the head, neck and chest. It is strictly forbidden to Muslim woman to unveil any single hair of her head, so they use many pins around the head to fix their Hijab. Often, while using pins they are self-pricked. Aim. The main aim of our work is to reveal a new cause of lymphadenopathy, which is not known till now. Material and methods. Retrospective study during the past five years among seventy-five female outpatients, visited our Oral and Maxillofacial clinic in dental department. Our data was collected according to medical history of patients; all female patients with cervical lymphadenopathy were using (A hijab). Results. Data collected of 75 female patients. Lymphadenopathy causes were various. Most of these causes resulted from nonspecific lymphadenitis (67 patients), 4 tuberculosis, 2 lymphoma, 2 cat scratch disease. Aetiology of 67 nonspecific lymphadenitis was 40 patients of dental cause, 10 of sore throat, 7 of acne vulgaris, 3 of mild facial injuries, and 7 of (Hijab pin pricks). Conclusion. Hijab pin prick cervical lymphadenitis in Islamic communities is not uncommon and, unexplained cervical lymphadenitis should be considered as potential cause

Źródło:

European Journal of Clinical and Experimental Medicine; 2020, 4; 286-288
2544-2406
2544-1361

Pojawia się w:

European Journal of Clinical and Experimental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:

A rare case of isolated pancreatic tuberculosis in a 70-year-old patient - a case report

Autorzy:

Słupski, Maciej
Wiciński, Michał
Khuat, Dawid
Pawlak-Osińska, Katarzyna

Powiązania:

https://bibliotekanauki.pl/articles/1392244.pdf

Data publikacji:

2019

Wydawca:

Index Copernicus International

Tematy:

pancreas
tuberculosis
tumor

Opis:

We report a case of rare solitary pancreatic tuberculoma. 70 years old woman admitted to hospital in order to conduct diagnostics of a tumor located in the head of the pancreas. All symptoms pointed at pancreatic cancer, but histopathological examinations were inconclusive. Additionally, there were no clinical signs or symptoms of tuberculosis in the lungs. X-ray of the chest showed no abnormalities. The patient denied tuberculosis in the medical interview. There were no bacilli in the sputum. During exploratory laparotomy, the samples of tissue have been taken for pathomorphological examination. The microscopic image caused suspicion of Mycobacterium tuberculosis etiology, which was confirmed by Ziehl-Neelsen staining. In recent years, tuberculosis has become more and more common in Europe, which is why the described case can be a guide for doctors to help to avoid diagnostic errors and speed up the treatment process.

Źródło:

Polish Journal of Surgery; 2019, 91, 2; 48-50
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:

A comprehensive review on Primary gallbladder tuberculosis

Autorzy:

Gupta, Ashish
Gupta, Amit
Anjum, Rohik
Agrawal, Saumya
Mallik, Dhiraj

Powiązania:

https://bibliotekanauki.pl/articles/1392736.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

gallbladder
Tuberculosis
Antitubercular drugs

Opis:

Tuberculosis (TB) is an infectious disease that can affect any organ system of the body. Abdominal TB can be gastrointestinal, lymph nodal, visceral or peritoneal. The gallbladder (GB) is rarely involved in abdominal TB as a primary organ. Extensive research literature on gallbladder TB is limited to case reports. There has been no review on this rare abdominal pathology. GB tuberculosis is a difficult diagnosis preoperatively. It is a rare differential among the more common gallbladder pathologies such as cholelithiasis, or a gallbladder malignancy. Typical histopathology of the resected specimen helps to establish this rare diagnosis. Subjecting every specimen to histopathological examination followed by medical treatment offers the chance of cure. Through this review, the authors attempt to provide an insight into this disease entity.

Źródło:

Polish Journal of Surgery; 2018, 90, 2; 10-12
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Tytuł:

Utajone zakażenie gruźlicą u polskich funkcjonariuszy służby więziennej
Latent tuberculosis infection in the Polish prison staff

Autorzy:

Filipek-Czerska, Aneta
Karczewski, Jan K.
Gładysz, Iwona

Powiązania:

https://bibliotekanauki.pl/articles/2081865.pdf

Data publikacji:

2021-08-31

Wydawca:

Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi

Tematy:

gruźlica
zakłady karne
latentne zakażenie prątkami gruźlicy
zakażenie Mycobacterium tuberculosis
infekcja utajona
służba więzienna
tuberculosis
penitentiaries
latent tuberculosis infection
Mycobacterium tuberculosis infection
latent infection
prison employees

Opis:

Gruźlica jest chorobą zakaźną wywoływaną przez prątki kwasooporne z grupy Mycobacterium tuberculosis complex. Choroba rozprzestrzenia się, gdy chorzy na gruźlicę płucną wydalają bakterie podczas kaszlu, kichania, śmiania się czy mówienia. Więzienia, które są często nazywane rezerwuarami chorych na gruźlicę, stwarzają duże zagrożenie dla zatrudnionych w nich osób. Dłuższy czas pracy w więzieniu i ośrodkach penitencjarnych sprzyja zakażeniu latentnemu wśród personelu więziennego. Dotychczas opublikowano niewiele prac dotyczących zagadnienia latentnego zakażenia prątkami gruźlicy wśród pracowników zakładów karnych.Materiał i metodyPrzebadano łącznie 84 pracowników zakładów karnych zlokalizowanych w województwie lubelskim. Zastosowano test QuantiFERON-TB Gold In-Tube (QFT-GIT), który w 2005 r. został zatwierdzony do użytku przez amerykańską Agencję ds. Żywności i Leków jako pomoc w diagnozowaniu zakażenia M. tuberculosis. Materiał do badań stanowiły próbki krwi pobrane metodą testu QFT-GIT.WynikiLatentne zakażenie gruźlicą stwierdzono u 16,6% funkcjonariuszy. Największy odsetek wyników dodatnich zaobserwowano wśród badanych funkcjonariuszek z zakładu karnego, w wieku 36–57 lat, stanu cywilnego wolnego. Nie wykazano istotnych statystycznie różnic między stanowiskiem pracy funkcjonariuszy służby więziennej a czynnikami ryzyka zakażenia gruźlicą latentną. Okazało się, że na ryzyko zakażenia gruźlicą wpływają staż pracy i kontakt z osadzonymi.Wnioski Wyniki badań częściowo potwierdzają obserwacje innych autorów dotyczące oddziaływania czynników ryzyka latentnego zakażenia gruźlicą pracowników zakładów karnych. W badanych zakładach karnych staż i kontakt miały wpływ na zakażenie. Med. Pr. 2021;72(4):415–422
Tuberculosis is a chronic infectious disease caused by acid-fast mycobacteria from the Mycobacterium tuberculosis complex group. The disease spreads when people with pulmonary tuberculosis excrete bacteria when they cough, sneeze, laugh or speak. Prisons are often called reservoirs of patients with tuberculosis, posing a great threat to their staff. Longer working hours in prison and penitentiary facilities aid latent contamination among the prison staff. So far, there have been few works discussing latent tuberculosis infection issues among the prisoners and prison staff.Material and MethodsA total of 84 employees of penitentiary facilities located in the Lublin Voivodship were examined using the QuantiFERON-TB Gold In-Tube (QFT-GIT) test which was approved for use in 2005 by the U.S. Food and Drug Administration as an aid in the diagnosis of Mycobacterium tuberculosis. The material for the research included blood samples collected using the QFT-GIT.ResultsPositive test results of latent tuberculosis infections were found in 16.6% of officers. The highest percentage with positive results of tuberculosis infections was found among the surveyed single women aged 36–57, working in penitentiary facilities. There have been no statistically significant differences between the position of officers and the risk factors increasing the chance of the latent tuberculosis infection. Work experience and contact with inmates were found to have an impact on tuberculosis infection.ConclusionsThe obtained results partially confirm other authors’ observations concerning the influence of the risk factors of latent tuberculosis infections in prisons. Work experience and contact with inmates have an impact on tuberculosis infections among the prison staff in the Lublin Voivodeship. Med Pr. 2021;72(4):415–22

Źródło:

Medycyna Pracy; 2021, 72, 4; 415-422
0465-5893
2353-1339

Pojawia się w:

Medycyna Pracy

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 16.

Tytuł:

Analysis of resistance to antimycobacterial drugs among MTBC strains isolated from cattle in Poland as a threat to human health
Analiza oporności na leki przeciwprątkowe wśród szczepów MTBC izolowanych od bydła w Polsce jako zagrożenie dla zdrowia ludzi

Autorzy:

Weiner, M.
Krajewska, M.
Zabost, A.
Augustynowicz-Kopeć, E.
Szulowski, K.

Powiązania:

https://bibliotekanauki.pl/articles/2048912.pdf

Data publikacji:

2020

Wydawca:

Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej

Tematy:

drug resistance
Mycobacterium tuberculosis
bovine tuberculosis
public health
antimicrobial
lekooporność
Mycobacterium tuberculosis complex
gruźlica bydlęca
zdrowie publiczne
leki przeciwprątkowe

Opis:

Background. Tuberculosis is a highly contagious disease affecting humans and animals. It is caused by mycobacteria that are part of the Mycobacterium tuberculosis complex (MTBC). The etiological agent causing bovine tuberculosis is mycobacteria bovis: Mycobacterium bovis and Mycobacterium caprae. According to the World Health Organization bovine tuberculosis is classified as direct zoonosis. Material and methods. The study material consisted of 129 MTBC strains isolated from Polish cattle, which were microbiologically analyzed. The resistance phenotype was tested for first-line anti-tuberculosis drugs used in the treatment of tuberculosis in humans. The drugs included streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. The MTBC strains tested in this study were isolated from cattle tissue post mortem so that the determination of drug resistance could meet only the epidemiological criterion. Results. Polish strains of mycobacteria bovis have not acquired environmental resistance despite the huge dynamics of changes in the phenotype of mycobacterial tuberculosis resistance. Strains classified as M. bovis are characterized by natural resistance to PZA, which is typical of this species. Conclusions. Drug resistance imposes the use of additional drugs. Drugs that are less effective than the basic drugs, drugs causing side effects more frequently and drugs that are much more expensive.
Wprowadzenie. Gruźlica jest wysoce zakaźną chorobą ludzi i zwierząt, którą powodują prątki wchodzące w skład kompleksu Mycobacterium tuberculosis (MTBC). Czynnikiem etiologicznym gruźlicy bydlęcej są prątki bydlęce: Mycobacterium bovis i Mycobacterium caprae. Zgodnie z klasyfikacją Światowej Organizacji Zdrowia, gruźlica typu bydlęcego zaliczana jest do zoonoz bezpośrednich. Materiał i metody. W pracy poddano analizie mikrobiologicznej 129 szczepów MTBC wyizolowanych od bydła w Polsce. Fenotyp oporności zbadano pod kątem leków przeciwprątkowych pierwszej linii stosowanych w leczeniu gruźlicy u ludzi: streptomycyny, izoniazydu, rifampicyny, etambutolu i pyrazynamidu. Szczepy MTBC badane w niniejszej pracy wyizolowano z tkanek bydła pobranych post mortem, tak że oznaczenie lekooporności w tym zadaniu spełniło jedynie kryterium epidemiologiczne. Wyniki. Polskie szczepy prątka bydlęcego nie nabyły oporności środowiskowej. Szczepy sklasyfikowane jako M. bovis cechują się charakterystyczną dla tego gatunku naturalną opornością na PZA. Wnioski. Wystąpienie lekooporności zmusza do stosowania leków dodatkowych, mniej skutecznych niż leki podstawowe i powodujących częściej objawy uboczne, a jednocześnie znacznie droższych.

Źródło:

Health Problems of Civilization; 2020, 14, 1; 24-28
2353-6942
2354-0265

Pojawia się w:

Health Problems of Civilization

Dostawca treści:

Biblioteka Nauki

/5

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Tytuł:

Human as a potential vector of bovine tuberculosis in cattle

Autorzy:

Krajewska-Wedzina, M.
Weiner, M.
Anusz, K.
Augustynowicz-Kopeć, E.
Lipiec, M.
Szulowski, K.

Powiązania:

https://bibliotekanauki.pl/articles/2085020.pdf

Data publikacji:

2019

Wydawca:

Instytut Medycyny Wsi

Tematy:

bovine tuberculosis
Mycobacterium bovis
epidemiology
zoonosis
mycobacteriology
public health
transmission
tuberculosis

Opis:

Introduction and objective. Bovine tuberculosis (bTB, bovine TB) is caused by mycobacteria which are grouped within the MTBC. TB in animals is a highly infectious and progressive disease which can be transmitted to humans. Since 2009, Poland has gained official bTB-free status. Despite the official fact of bTB-free status, a dozen bTB outbreaks are still noted each year. Since 2000 in Poland, every year 1/5 of the national herd is subject to intradermal skin TB testing to control the bTB outbreaks in the cattle population. Application, with 5-year intervals between each government-funded skin test, undoubtedly resulted in financial savings. However it also seems to have caused several adverse and worrying events, e.g. an increase in the number of reactors detected and removed from a single tested herd. The objective of this study was the examination of 898 cattle imputed with bTB infection in Poland between 2008–2012. Materials and method. The study concerned a potential epidemic outbreak with suspected bTB transmission. 20 cows came from 3 herds in the same county located in the same province in southern Poland. Results. 134 MTBC strains were identified. In MIRU-VNTR, all isolates showed the same genetic pattern 322532243421232. Based on molecular investigation, the characteristics of M. bovis strains isolated from cattle from 3 different herds confirmed the common source of this zoonotic disease. Conclusions. Although not bacteriologically proven, everything points to the fact that humans were the vector of bovine tuberculosis transmission between herds. This finding confirms transmission between 3 cattle herds in the Małopolskie Province in southern Poland (Podhale). The outbreak of tuberculosis in animals finally compromised public health.

Źródło:

Annals of Agricultural and Environmental Medicine; 2019, 26, 3; 396-399
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

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Tytuł:

A case of bovine tuberculosis in pigs in Poland - a country free from the disease

Autorzy:

Lipiec, M.
Radulski, L.
Szulowski, K.

Powiązania:

https://bibliotekanauki.pl/articles/2082990.pdf

Data publikacji:

2019

Wydawca:

Instytut Medycyny Wsi

Tematy:

pigs
bovine tuberculosis
eradication

Opis:

Introduction. Bovine tuberculosis is a chronic contagious disease caused by Mycobacterium bovis or Mycobacterium caprae. Before widespread action conducted in Poland between 1959–1975 to combat bovine tuberculosis (BTB), about 40% of all tuberculosis cases in pigs was caused by the bovine bacillus. At the present time, correctly carried out, long-term control of cattle has resulted in cases of bovine tuberculosis in pigs and humans being extremely rare and sporadic. In pigs, tuberculosis is most often caught in a slaughterhouse during slaughter. Materials and method. Samples came from pigs kept on the farm. Traditional bacteriological methods on solid media (Stonebrink, LJ with pyruvate) supported by the semi-automatic, liquid indicative culture method (MGIT) and PCR test were applied in targeted studies. The GenoType Mycobacterium MTBC and CM tests (Hain Lifescience, Germany) were used to additionally confirm that isolated strains classification was used. Results. Strains of mycobacteria were isolated from all examined pigs. Mycobacterium bovis was determined by real time PCR and Hain Genotype methods. Conclusions. In order to effectively fight against BTB, all animals on farms should be tested, regardless of species, while the milk of suspected cows should be utilized without being used for feed. It is important to adapt the current legal regulations to the current epidemiological situation.

Źródło:

Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 29-32
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 19.

Tytuł:

Immune response gene polymorphisms in tuberculosis

Autorzy:

Fol, Marek
Druszczynska, Magdalena
Wlodarczyk, Marcin
Ograczyk, Elzbieta
Rudnicka, Wieslawa

Powiązania:

https://bibliotekanauki.pl/articles/1038871.pdf

Data publikacji:

2015

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

tuberculosis
susceptibility/resistance genes

Opis:

Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (M.tb), remains a leading public health problem in most parts of the world. Despite the discovery of the bacilli over 100 years ago, there are still many unanswered questions about the host resistance to TB. Although one third of the world's population is infected with virulent M.tb, no more than 5-10% develop active disease within their lifetime. A lot of studies suggest that host genetic factors determine the outcome of M.tb-host interactions, however, specific genes and polymorphisms that govern the development of TB are not completely understood. Strong evidence exists for genes encoding pattern recognition receptors (TLR, CD14), C-type lectins, cytokines/chemokines and their receptors (IFN-γ, TNF-α, IL-12, IL-10, MCP-1, MMP-1), major histocompatibility complex (MHC) molecules, vitamin D receptor (VDR), and proton-coupled divalent metal ion transporters (SLC11A1). Polymorphisms in these genes have a diverse influence on the susceptibility to or protection against TB among particular families, ethnicities and races. In this paper, we review recent discoveries in genetic studies and correlate these findings with their influence on TB susceptibility.

Źródło:

Acta Biochimica Polonica; 2015, 62, 4; 633-640
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 20.

Tytuł:

Duodenal Tuberculosis – A Rare Case Report and Review of Literature

Autorzy:

Dahiya, Divya
Garg, Mandeep
Kaman, Lileswar
Rana, Surinder
Rao, Chalapathi
Behera, Arunanshu

Powiązania:

https://bibliotekanauki.pl/articles/1396191.pdf

Data publikacji:

2013-08-01

Wydawca:

Index Copernicus International

Tematy:

duodenal tuberculosis
duodenal obstruction

Opis:

Extrapulmonary tuberculosis is rare and often difficult to diagnose infection. We report a case of duodenal tuberculosis, who presented with upper gastrointestinal symptoms. There was evidence of obstruction in the third part of duodenum (D3) on oesophagogastro endoscopy, barium meal follow through and CT scan of abdomen. On exploration there was thickening of D3 and D4 causing luminal obstruction. Resection of stricturous segment with end-to-side duodenojejunostomy was done. Biopsy of the diseased segment was tubercular. Antitubercular treatment was given to the patient for 6 months and he is doing well on follow up (1 year after surgery). Duodenal tuberculosis being the rarest form of intestinal tuberculosis poses great difficulty in diagnosis. High index of suspicion supported by radiological investigation, exploratory laparotomy and histopathological examination of the tissue can only lead to a definitive diagnosis of this rare condition. Treatment is both surgical which involves resection or by-pass for an obstructive lesion and medical which includes antitubercular therapy

Źródło:

Polish Journal of Surgery; 2013, 85, 8; 464-466
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 21.

Tytuł:

A novel method of Mycobacterium tuberculosis complex strain differentiation using polymorphic GC-rich gene sequences

Autorzy:

Kotłowski, Roman

Powiązania:

https://bibliotekanauki.pl/articles/1039112.pdf

Data publikacji:

2015

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Mycobacterium tuberculosis complex
PGRS
genotyping

Opis:

Tuberculosis is one of the leading infectious diseases. In this work, a new genotyping method of Mycobacterium tuberculosis (Mtb) complex strain is presented. 27 Mtb genomes were analyzed for the presence of length polymorphism within polymorphic GC-rich gene sequences. Four genes, Rv3345c, Rv3507, Rv0747 and Rv3511, showing variation in length depending on the Mtb strain were selected for designing primer sequences flanking variable regions for the PCR method. Identification of 16 genotypes among 27 analyzed genomes demonstrated usefulness of our genotyping method in differentiation of Mtb genomes based on sequence polymorphism in the four PGRS genes.

Źródło:

Acta Biochimica Polonica; 2015, 62, 2; 317-322
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 22.

Tytuł:

Lymphoma co existing with Tuberculosis granulomatous

Autorzy:

Subhan, Madeeha
Sadiq, Waleed

Powiązania:

https://bibliotekanauki.pl/articles/1178816.pdf

Data publikacji:

2017

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

Hodgkin
Tuberculosis granulomatous
cervical
lymphoma

Opis:

Hodgkin lymphoma is malignant condition with good prognosis. Asymptomatic lymphadenopathy is a manifestation with cervical, supraclavicular and mediastinal lymph nodes.

Źródło:

World Scientific News; 2017, 90; 265-270
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 23.

Tytuł:

A comprehensive review of primary gall bladder tuberculosis

Autorzy:

Gupta, Ashish
Gupta, Amit
Anjum, Rohik
Agrawal, Saumya
Mallik, Dhiraj

Powiązania:

https://bibliotekanauki.pl/articles/1392422.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

Gall bladder
Tuberculosis
Antitubercular drugs

Opis:

Tuberculosis (TB) is an infectious disease that can involve any organ system of the body. Abdominal TB can be gastrointestinal, lymph-nodal, visceral or peritoneal. Gall bladder (GB) is rarely involved as a primary organ in abdominal TB. On extensive research, the literature on gall bladder TB is limited to case reports. There has been no review on this rare abdominal pathology. The GB tuberculosis is difficult to diagnose preoperatively. It is a rare differential among the more common gall bladder pathologies like cholelithiasis, or a gall bladder malignancy. Standard histopathology of a resected specimen helps in this rare diagnosis. Subjecting every specimen to histopathological examination followed by medical treatment offers a chance to cure. Through this review the authors have tried to provide an insight into this entity.

Źródło:

Polish Journal of Surgery; 2018, 90, 4; 52-54
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 24.

Tytuł:

Płucna postać gruźlicy u 14-letniej dziewczynki – trudności diagnostyczne
Pulmonary tuberculosis in a 14-year-old girl – diagnostic difficulties

Autorzy:

Lipińska-Opałka, Agnieszka
Wawrzyniak, Agata
Kalicki, Bolesław
Jung, Anna
Koziarska, Teresa

Powiązania:

https://bibliotekanauki.pl/articles/1032945.pdf

Data publikacji:

2013

Wydawca:

Medical Communications

Tematy:

BCG
childhood tuberculosis
mycobacterium
tuberculosis treatment
gruźlica dziecięca
bcg
zapalenie płuc
prątki
leczenie gruźlicy

Opis:

Tuberculosis is still a significant clinical problem. Rate of incidence of the disease in the paediatric population is a good measure of the epidemiological situation in the area. Tuberculosis in children, always primary, is significantly different in its course from tuberculosis in adults. The most common form in children is a disease of the lung parenchyma and the clinical course may be atypical, crafty, oligosymptomatic and carried out under the guise of clinical other diseases. The diagnosis of tuberculosis in children is based on carefully collected history, clinical examination and the results of additional tests (tuberculin skin test, chest X-ray and sputum smear microscopy). Microbiological test result is the gold standard. Gastric lavage were collected to study in young children, in older – induced sputum concentrated solution of NaCl or bronchial lavage obtained during bronchoscopy. The only available vaccine against tuberculosis is BCG. In Poland, the vaccination is carried out in the first 24 hours of life for all neonates who do not have contraindications. The BCG vaccine does not protect against the disease, but only reduces the number of severe forms of tuberculosis in children. Treatment options include combination regimens consisting of two phases: a phase of intensive treatment of sterilization and a continuation phase. The article presents a case study of 14-year-old girl hospitalized in the Department of Paediatrics, Paediatric Nephrology and Allergology, because of lack of improvement in outpatient treatment of pneumonia. Due to the absence of regression of inflammatory changes on the chest radiographs and persistent auscultatory changes of the lung fields, a series of tests was performed, finally recognizing tuberculosis.
Gruźlica nadal stanowi istotny problem kliniczny. Ocena zapadalności na tę chorobę w populacji dziecięcej jest dobrym miernikiem sytuacji epidemiologicznej na danym terenie. Gruźlica dziecięca, zawsze pierwotna, znacząco różni się w swym przebiegu od gruźlicy dorosłych. Najczęstszą jej postacią u dzieci jest choroba miąższu płuc, której przebieg kliniczny może być nietypowy, podstępny, skąpoobjawowy – choroba długo może przebiegać pod maską kliniczną innych schorzeń. Rozpoznanie gruźlicy u dzieci opiera się na dokładnie zebranym wywiadzie, badaniu klinicznym oraz wynikach badań dodatkowych (tuberkulinowy test skórny, badanie radiologiczne klatki piersiowej oraz mikroskopowy rozmaz plwociny). Za złoty standard uważa się wynik badania mikrobiologicznego. U małych dzieci do badania pobierane są popłuczyny żołądkowe, u starszych plwocina indukowana stężonym roztworem NaCl lub popłuczyny oskrzelowe uzyskane podczas bronchoskopii. Jedyną dostępną szczepionką przeciwko gruźlicy jest BCG. W Polsce szczepienie wykonuje się w pierwszych 24 godzinach życia u wszystkich noworodków, u których nie stwierdza się przeciwwskazań. Szczepionka BCG nie chroni przed zachorowaniem, zmniejsza jedynie liczbę przypadków ciężkich postaci gruźlicy u dzieci. W leczeniu stosuje się skojarzone schematy, składające się z dwóch etapów: fazy intensywnego leczenia wyjaławiającego i fazy leczenia podtrzymującego. W artykule przedstawiono przypadek 14-letniej dziewczynki hospitalizowanej w Klinice Pediatrii, Nefrologii i Alergologii Dziecięcej z powodu braku poprawy leczenia ambulatoryjnego zapalenia płuc. Z uwagi na brak regresji zmian zapalnych w badaniu radiologicznym klatki piersiowej oraz utrzymujące się zjawiska osłuchowe nad polami płucnymi wykonano szereg badań, rozpoznając ostatecznie gruźlicę płuc.

Źródło:

Pediatria i Medycyna Rodzinna; 2013, 9, 3; 282-286
1734-1531
2451-0742

Pojawia się w:

Pediatria i Medycyna Rodzinna

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 25.

Tytuł:

Tuberculosis in Polish zoos as health risk for humans
Gruźlica w polskich ogrodach zoologicznych w aspekcie zdrowia publicznego

Autorzy:

Krajewska-Wędzina, M.
Augustynowicz-Kopeć, E.
Weiner, M.
Orłowska, B.
Anusz, K.
Szulowski, K.

Powiązania:

https://bibliotekanauki.pl/articles/2052755.pdf

Data publikacji:

2017

Wydawca:

Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej

Tematy:

zoonosis
Mycobacterium tuberculosis complex
tuberculosis
public health
transmission
zoonoza
gruźlica
zdrowie publiczne
transmisja

Opis:

Introduction. Tuberculosis is an infectious disease of humans and animals caused by the organism of the Mycobacterium tuberculosis complex (MTBC). It is one of the most widespread infectious diseases occurring in zoos. Taking into account the number of visitors to these sites, tuberculosis remains a major public health problem. Material and methods. The study material consisted of lymph nodes, and internal organs collected post mortem from five zoo animals suspected of tuberculosis: antelope, two tapirs, alpaca and bison. The animals came from the zoos in Gdańsk, Wrocław and Chorzów. The microbiological analysis of 5 MTBC strains was performed to determine the molecular relationships among them. Results. Five strains were isolated in the microbiological examination, 3 of which were identified as Mycobacterium bovis and 2 − as Mycobacterium caprae. 3 spoligotypes, i.e. SB1912, SB0856, SB2416, were obtained by spoligotyping. To confirm the transmission of tuberculosis in the studied animal population, the MIRU-VNTR method was applied. The unique patterns were assigned to 3 strains and the other 2 of the same pattern were assigned to one cluster, which would indicate the transmission of tuberculosis among animals. Conclusions. The obtained results exclude the transmission of tuberculosis between zoos.
Wprowadzenie. Gruźlica jest zakaźną chorobą ludzi i zwierząt, którą powodują prątki wchodzące w skład kompleksu Mycobacterium tuberculosis (MTBC). Jest jedną z najbardziej rozpowszechnionych chorób zakaźnych występujących w zoo. Biorąc pod uwagę liczbę odwiedzających te miejsca, gruźlica stanowi niebezpieczeństwo dla zdrowia publicznego. Materiał i metody. Materiał do badań stanowiły węzły chłonne i narządy wewnętrzne pobrane post mortem od pięciu zwierząt z zoo podejrzanych o gruźlicę: antylopy, dwóch tapirów anta, alpaki i żubra. Zwierzęta pochodziły z zoo w Gdańsku, Wrocławiu i Chorzowie. W pracy poddano analizie mikrobiologicznej 5 szczepów MTBC i określono pokrewieństwo molekularne pomiędzy nimi. Wyniki. W wyniku badania mikrobiologicznego wyizolowano 5 szczepów, 3 zidentyfikowano jako M. bovis a 2 jako M. caprae. Metodą spoligotyping uzyskano 3 spoligotypy (SB1912, SB0856, SB2416). Do potwierdzenia zjawiska transmisji gruźlicy w badanej populacji zwierząt, zastosowano metodę MIRU-VNTR. Wzory unikalne przyporządkowano 3 szczepom, a pozostałe 2 szczepy o takich samych wzorach zostały przydzielone do wspólnego klasteru świadczącego o zaistniałej transmisji prątków gruźlicy pomiędzy zwierzętami. Wnioski. Uzyskane wyniki pozwoliły wykluczyć transmisję gruźlicy między ogrodami zoologicznymi.

Źródło:

Health Problems of Civilization; 2017, 11, 4; 233-238
2353-6942
2354-0265

Pojawia się w:

Health Problems of Civilization

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 26.

Tytuł:

Comparative analysis of the effectiveness of tuberculosis prophylaxis in patients with HIV/AIDS treated with isoniazid

Autorzy:

Juszkiewicz, K.
Jarosz, M.J.
Włoszczak-Szubzda, A.
Głowacka, M.

Powiązania:

https://bibliotekanauki.pl/articles/2084999.pdf

Data publikacji:

2019

Wydawca:

Instytut Medycyny Wsi

Tematy:

HIV
AIDS
isoniazid
tuberculosis prophylaxis

Opis:

Introduction. The epidemic of human immunodeficiency virus has had a tremendous effect on the epidemic of tuberculosis. Together with the spread of HIV, a great increase has been observed in morbidity due to tuberculosis, both in endemic countries and in those where earlier, as a result of treatment, the frequency of occurrence of tuberculosis had decreased. In 2018, the WHO data demonstrated that the EECA region was the only region worldwide where the epidemics of HIV was still rapidly increasing. The EECA region still struggles with a serious epidemic of tuberculosis. Materials and method. The research method applied was comparative analysis of the results of own study and studies by other researchers, concerning the effectiveness of tuberculosis prophylaxis in patients with HIV/AIDS when treated with isoniazid. Results. In own study, it was found that primary morbidity among patients administered isoniazid significantly decreased within 5 years. Incidence rates of primary morbidity were significantly lower than among patients who had not received isoniazid. Relevant studies conducted worldwide, in many cases differed from own study with respect to both the results and approach to the problem, by country or selection of the type of patients participating in the study. However, in all studies, isoniazid was generally a safe and well-tolerated drug, without special side-effects. Conclusions. All studies analyzed concerning the effectiveness of tuberculosis prophylaxis in patients with HIV/AIDS treated with isoniazid, confirmed the effectiveness of this drug. In the compared studies, applied isoniazid preventive therapy showed no difference in effectiveness according to its duration. Analyzed studies showed similar effectiveness also with respect to a decrease in mortality among patients with TB/HIV/AIDS.

Źródło:

Annals of Agricultural and Environmental Medicine; 2019, 26, 3; 462-467
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 27.

Tytuł:

Pulmonary tuberculosis in childhood: clinical features, treatment side effects and factors associated with radiologic improvement

Autorzy:

Batmaz, S.B.

Powiązania:

https://bibliotekanauki.pl/articles/2088011.pdf

Data publikacji:

2020

Wydawca:

Uniwersytet Opolski. Instytut Nauk o Zdrowiu

Tematy:

child
prognosis
pulmonary
radiological
tuberculosis

Opis:

Background: Tuberculosis (TB) is a common public health problem and early diagnosis and treatment is important. Aim of the study: The aim was to evaluate complaints and radiological features, drug side effects, changes in radiological findings after treatment, and to evaluate the factors affecting this change in patients with pulmonary TB. Material and methods: One hundred patients with pulmonary TB were evaluated, and the following data recorded: age, gender, contact with TB patient, complaints, physical examination, tuberculin skin test, acid resistant bacillus, polymerase chain reaction and culture results, posteroanterior/lateral chest radiographs and thorax computed tomography findings at presentation and after treatment, treatment duration, and side effects. Treatment adherence and follow-up data were evaluated, and radiological findings before and after treatment were compared. In predicting radiological improvement, the effects of age, sex, duration of complaints, living in in rural/urban areas, treatment duration, treatment adherence, follow-up, and presence of cavitation were examined. Results: Mean age was 6.0 ± 4.2 years. 66 of the patients had contact history with TB patients. The most common complaint was cough, whilst infiltration and/or mediastinal lymphadenopathy were the most common findings in radiological examination at presentation. 84 patients were scheduled a treatment program for 6 months. Improvement in radiological findings were significantly better in patients who adhered to medication and follow-up protocols. Age, sex, complaint duration, living in rural/urban areas, treatment duration and presence of cavitation were not significantly associated with radiological improvement. Conclusions: Pulmonary TB should be considered in patients presenting with cough, even if their physical examination and chest radiographs are normal. Adherence to anti-tuberculosis treatment and follow-up were the most important factors in radiological improvement.

Źródło:

Medical Science Pulse; 2020, 14, 1; 4-9
2544-1558
2544-1620

Pojawia się w:

Medical Science Pulse

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 28.

Tytuł:

Splenic tuberculosis: a comprehensive review of literature

Autorzy:

GUPTA, ASHISH

Powiązania:

https://bibliotekanauki.pl/articles/1392896.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

tuberculosis
spleen
anti tubercular therapy

Opis:

Tuberculosis(TB) is one of the most common infections affecting the population in the developing countries. With the rising human immunodeficiency(HIV) infection its incidence is on a rise even in the developed countries. Pulmonary TB is the commonest form of infection, However multiple extrapulmonary sites have also been reported. Spleen is thought to be a rare organ involved in this infection. Various presentations of the splenic TB have been reported in literature.The definitive diagnosis of this is essentially formulated on the post splenectomy specimen. A consensus statement based on the available case reports is lacking. The authors are providing an insight into this form of extrapulmonary TB after reviewing the available literature.

Źródło:

Polish Journal of Surgery; 2018, 90, 5; 49-51
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Tytuł:

Gruźlica u dzieci – od diagnostyki do chemioprofilaktyki i leczenia
Tuberculosis in children – from diagnostics to chemoprophylaxis and treatment

Autorzy:

Kosińska, Joanna
Górski, Paweł
Grzelewska-Rzymowska, Iwona

Powiązania:

https://bibliotekanauki.pl/articles/1033210.pdf

Data publikacji:

2014

Wydawca:

Medical Communications

Tematy:

BCG vaccine
IGRA tests
latent tuberculosis
multidrug-resistant tuberculosis
tuberculosis in children
gruźlica u dzieci
gruźlica utajona
gruźlica wielolekooporna
testy igra
szczepienia bcg

Opis:

Tuberculosis is a disease known to the mankind for centuries, but still poses a big social problem and a challenge for the twenty-first century medicine. It is estimated that at least 30% of the global population is infected with the tubercle bacillus. The disease develops in 9 million people annually, including 1 million children aged below 15. Tuberculosis in the paediatric population requires particular attention because the incidence in this age group is a measure of the epidemiological situation of tuberculosis in a given area. Diagnosis of tuberculosis in children is particularly difficult due to its sparse and non-specific symptoms, imitating other diseases and increasing number of cases of mycobacterial infection without clinical, radiological and microbiological symptoms – so-called latent tuberculosis. If conditions are favourable, latent mycobacterial infection may develop into an active disease and therefore the authors draw attention to the need for rapid diagnosis of infection with Mycobacterium tuberculosis and describe the existing diagnostic methods (tuberculin skin test, interferon-gamma release assays) as well as indications for chemoprophylaxis and principles of conducting it in children. Moreover, the authors also emphasise the necessity for a thorough interview and physical examination, analysis of sputum-positive patient’s contacts, imaging and microbiological tests as well as a significant role of family physicians and paediatricians. Due to the growing phenomenon of resistance of mycobacteria to different drugs (according to the WHO, the general number of new cases of MDR-TB and XDR-TB diagnosed in 2012 amounts to 450 thousand), the issue of multidrug-resistant tuberculosis as well as its treatment and available medications are discussed.
Choć gruźlica jest chorobą znaną ludzkości od stuleci, nadal stanowi duży problem społeczny i wyzwanie dla medycyny XXI wieku. Ocenia się, że co najmniej 30% światowej populacji jest zakażone prątkami gruźlicy. Choroba rocznie rozwija się u 9 milionow ludzi, w tym u 1 miliona dzieci poniżej 15. roku życia. Szczegolnej uwagi wymaga gruźlica właśnie w populacji dziecięcej, gdyż zapadalność w tej grupie wiekowej jest miernikiem sytuacji epidemiologicznej gruźlicy na danym terenie. Rozpoznawanie gruźlicy u dzieci jest szczegolnie trudne ze względu na jej skąpe i nieswoiste objawy, imitowanie innych jednostek chorobowych oraz zwiększającą się liczbę przypadkow zakażenia prątkami bez objawow klinicznych, radiologicznych i mikrobiologicznych – tzw. gruźlicy latentnej. Utajone zakażenie prątkiem gruźlicy może w dogodnych warunkach ulec progresji w czynną postać choroby i dlatego autorzy zwracają uwagę na konieczność szybkiej diagnostyki zakażenia Mycobacterium tuberculosis, opisują służące temu metody (OT, IGRA), wskazania do włączenia chemioprofilaktyki i zasady jej prowadzenia u dzieci. Podkreślają konieczność przeprowadzania wnikliwego badania podmiotowego, przedmiotowego, analizy kontaktow z osobą prątkującą, badań obrazowych i mikrobiologicznych oraz znaczącą rolę lekarzy rodzinnych i pediatrow w tym procesie. Ze względu na narastające zjawisko oporności prątkow na leki (według WHO ogolna liczba przypadkow MDR-TB i XDR-TB na świecie wśrod nowo zdiagnozowanych przypadkow w 2012 roku wynosiła 450 tys.) poruszają problematykę gruźlicy wielolekoopornej, zasady prowadzenia leczenia oraz stosowane leki.

Źródło:

Pediatria i Medycyna Rodzinna; 2014, 10, 2; 111-127
1734-1531
2451-0742

Pojawia się w:

Pediatria i Medycyna Rodzinna

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 30.

Tytuł:

Animal tuberculosis as a potential danger to men
Gruźlica zwierząt jako potencjalne zagrożenie dla człowieka

Autorzy:

Krajewska, M.
Weiner, M.
Augustynowicz-Kopeć, E.

Powiązania:

https://bibliotekanauki.pl/articles/2052645.pdf

Data publikacji:

2017

Wydawca:

Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej

Tematy:

Mycobacterium tuberculosis complex
bovine tuberculosis
public health
zoonosis
transmission
gruźlica bydlęca
zdrowie publiczne
zoonoza
transmisja

Opis:

Tuberculosis (latin: tuberculosis) is an infectious disease which affects man and many species of animals. The aetiological factor of tuberculosis are bacillus which belong to the Mycobacterium tuberculosis complex (MTBC) while their host preferences, gene sequence and the level of drug resistance can differ. MTBC constitute a morphologically and biochemically homogeneous group of bacteria which mainly spreads through the aerogenic channel on small, dry particles of phlegm called droplet nuclei which are discharged while infected people or animals cough. Infection occurs after predisposed individual inhales into his or her lungs the bacilli, where they easily multiply in the soft lungs tissue and cause infection. The World Health Organization (WHO) classified bovine tuberculosis (bTB) as direct zoonosis, in which case the transmission of disease is possible without the indirect host’s involvement. Moreover, bTB is the best example of anthroponosis, when the disease is transferred from animal to men. The possibility of dividing the strains of animal bacillus into the two genres: M. bovis and M. caprae raises some significant legal concerns in Europe since in many of its countries, including among others Poland, caprae is not considered to be an etiological factor of bTB.
Gruźlica (łac. tuberculosis) jest zakaźną chorobą ludzi i wielu gatunków zwierząt. Czynnikiem etiologicznym gruźlicy są prątki należące do Mycobacterium tuberculosis complex (MTBC), różniące się między sobą różnym powinowactwem do rodzaju gospodarza, sekwencjami w genach oraz cechami lekooporności. Stanowią niejednorodną grupę pod względem morfologicznym i biochemicznym. Prątki należące do kompleksu tuberculosis przenoszone są głównie drogą aerogenną na małych, wyschniętych cząstkach śluzu zwanych jądrami kropelek (droplet nuclei), które są wydzielane w czasie kaszlu chorych ludzi i zwierząt. Zakażenie następuje, gdy wrażliwy na zakażenie osobnik zaaspiruje prątki do płuc, gdzie w delikatnej tkance mogą się one rozmnażać dając początek infekcji. Zgodnie z klasyfikacją Światowej Organizacji Zdrowia (WHO) gruźlica bydlęca zaliczana jest do zoonoz bezpośrednich, gdzie przeniesienie czynnika infekcyjnego odbywa się bez pomocy żywicieli pośrednich. Ponadto gruźlica zwierząt jest najlepszym przykładem antropozoonozy, gdzie transmisja choroby możliwa jest ze zwierzęcia na człowieka. Możliwość różnicowania szczepów prątka bydlęcego na gatunki M. bovis i M. caprae rodzi w Europie istotne wątpliwości prawne, ponieważ w wielu krajach caprae nie widnieje jako czynnik etiologiczny gruźlicy bydlęcej, w tym m. in. w Polsce.

Źródło:

Health Problems of Civilization; 2017, 11, 1; 10-14
2353-6942
2354-0265

Pojawia się w:

Health Problems of Civilization

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 31.

Tytuł:

Lekooporność w gruźlicy - aspekty mikrobiologiczne i kliniczne.
Drug resistance in tuberculosis - microbiological and clinical aspects.

Autorzy:

Jagielski, Tomasz

Powiązania:

https://bibliotekanauki.pl/articles/1034227.pdf

Data publikacji:

2017

Wydawca:

Polskie Towarzystwo Przyrodników im. Kopernika

Tematy:

gruźlica
leki przeciwprątkowe
lekooporność
mutacje
Mycobacterium tuberculosis

Opis:

Gruźlica pozostaje nadal jednym z największych zagrożeń zdrowotnych dla populacji ludzkiej. Każdego roku notuje się około 9 mln nowych zachorowań na gruźlicę i blisko 2 mln zgonów z powodu tej choroby. Wśród najważniejszych czynników, które negatywnie wpływają na sytuację epidemiologiczną gruźlicy w świecie jest lekooporność wywołujących ją prątków Mycobacterium tuberculosis. Szczególne znaczenie ma oporność typu MDR (ang. multidrug resistance), definiowana jako oporność prątków na co najmniej izoniazyd (INH) irifampicynę (RMP), dwa kluczowe leki stosowane w terapii gruźlicy.
Główną rolę w kształtowaniu oporności na leki przeciwprątkowe odgrywają spontaniczne mutacje w genach kodujących białka lub RNA będące często, choć nie zawsze, celami molekularnymi tych leków. W szczepach M. tuberculosis mutacje występują z różną częstością i w różny sposób kształtują ich fenotyp lekooporności, co wyraża się odmiennym mianem oporności szczepu na dany lek przeciwprątkowy.
Niniejsza praca omawia najważniejsze zagadnienia związane z lekoopornością w gruźlicy, w tym epidemiologię, diagnostykę i leczenie gruźlicy lekoopornej. Najwięcej miejsca w pracy zajmuje charakterystyka leków stosowanych obecnie w leczeniu gruźlicy, ze szczególnym uwzględnieniem mechanizmów ich działania i oporności na nie prątków.
Tuberculosis (TB) still persists as a significant health problem for the entire human population. Every year, about 9 million people develop TB, and nearly 2 million die from the disease. Among major factors that influence current TB epidemiology is drug resistance of its causative agent - Mycobacterium tuberculosis. Of particular importance is multidrug resistance, defined as resistance of tubercle bacilli to at least isoniazid (INH) and rifampicin (RMP), the two most potent anti-TB drugs.
The pivotal role in the development of drug resistance in tubercle bacilli is attributed to spontaneous mutations in genes coding for proteins or RNAs that often, yet not always, serve as molecular targets for anti-TB therapeutics. These mutations occur at different frequencies in M. tuberculosis strains and differently impact the level of resistance to a specific drug.
This review addresses the most important issues related to drug-resistance in TB, including epidemiology, diagnostics, and treatment strategies for drug-resistant TB. A substantial part of the article is devoted to anti-TB drug’s profiles, with particular emphasis on their modes of action and mechanisms of resistance.

Źródło:

Kosmos; 2017, 66, 1; 41-58
0023-4249

Pojawia się w:

Kosmos

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 32.

Tytuł:

Health Education and Information: a Panacea to Tuberculosis Prevention and Eradication in Nigeria

Autorzy:

Fasoranti, Afolabi Joseph

Powiązania:

https://bibliotekanauki.pl/articles/1182892.pdf

Data publikacji:

2016

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

health education
tuberculosis
eradication
communicable diseases
nigeria

Opis:

Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis. Tuberculosis is a major public health problem in Nigeria, being one of the ten leading causes of hospital admissions and a leading cause of death in adults, especially among the economically productive age group. This paper critically examined the importance of health education towards the eradication and prevention of tuberculosis in Nigeria. It was reviewed and discussed under the following subheadings; Global burden of tuberculosis in Nigeria, concept, definition and etiology of tuberculosis Signs and symptoms of tuberculosis, diagnosis of tuberculosis, causative agent, modes of infection and incubation period, risk factors of pulmonary tuberculosis Dots and stop TB programmes in Nigeria Treatment and prevention of tuberculosis TB treatment strategies Dealing with treatment problems in Nigeria Stigmatization against Tuberculosis Patients Health education as a tool for achieving free tuberculosis country. Emphasis for Tb control has been placed on the development of improved vaccines, diagnostic and treatment courses but less on health education and awareness. Although the need for theses tools is indisputable, the obstacle facing the spread of TB go beyond technological. The findings of this study may stimulate health system policy makers, Government and non- governmental organizations, donor agencies amd other stakeholders in planning and designing health education intervention programmes on the control and eradication of tuberculosis. It therefore recommended that Government should implement health education as part of the DOTs, this will thus empower the tuberculosis patients on ways to live healthy, lifestyle, in doing this, they will recover fastly and prevent them from spreading the disease.

Źródło:

World Scientific News; 2016, 53, 3; 323-342
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 33.

Tytuł:

Current infectious threats associated with the development of civilization and progress in medicine - methods of prevention and education

Autorzy:

Kozioł-Montewska, M.
Pańczuk, A.
Tokarska-Rodak, M.
Paluch-Oleś, J.
Gładysz, I.
Sikora, A.
Filipek-Czerska, A.
Kawka, E.
Pawłowicz, E.
Kosińska, B.
Montewka, M.
Skrzek, A.
Kozioł, M.
Gozd-Barszczewska, A.
Barszczewski, P.
Spisacka, S.

Powiązania:

https://bibliotekanauki.pl/articles/2052218.pdf

Data publikacji:

2014

Wydawca:

Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej

Tematy:

Lyme disease
legionellosis
tuberculosis
microbiome
antibiotic resistance

Opis:

The development of civilization, economic growth, urbanization, industrialization and progress in medicine bring to the society an improvement in the quality of life, but at the same time caused changes in lifestyle, environmental conditions, and changes in the natural environment. All of these led to develop civilization diseases which have critical impact and the adverse effect on our health, about what we not always realize. In the past fifty years, about 30 new pathogens appeared causing diseases such as legionellosis, Lyme disease, and increase unexpectedly tuberculosis incidence which in some regions is associated with HIV infections. Also widespread use of antibiotics caused and still causing bacterial resistance increase to most of them. With the development of medicine and surgery, parallel effects of surgical areas and infections associated with implanted cardiac devices in the majority of the life-saving ones appeared. The development of research techniques allowed for the finding of new relationships between ecosystems in the microbiome of the gastrointestinal tract with of obesity in the society. The presence of new health aspects of civilization diseases impose pressure to create new prevention methods and public education.

Źródło:

Health Problems of Civilization; 2014, 08, 1; 6-14
2353-6942
2354-0265

Pojawia się w:

Health Problems of Civilization

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 34.

Tytuł:

Mycobacterium caprae - the first case of the human infection in Poland

Autorzy:

Kozińska, M.
Krajewska-Wędzina, M.
Augustynowicz-Kopeć, E.

Powiązania:

https://bibliotekanauki.pl/articles/2085343.pdf

Data publikacji:

2020

Wydawca:

Instytut Medycyny Wsi

Tematy:

bovine tuberculosis
Mycobacterium bovis
Mycobacterium caprae
zoonosis

Opis:

The strain of tuberculous mycobacteria called Mycobacterium caprae infects many wild and domestic animals; however, because of its zoonotic potential and possibility of transmission between animals and humans, it poses a serious threat to public health. Due to diagnostic limitations regarding identification of MTB strains available data regarding the incidence of M. caprae, human infection does not reflect the actual size of the problem. Despite the fact that the possible routes of tuberculosis transmission are known, the epidemiological map of this zoonosis remains underestimated. The progress in diagnostic techniques, application of advanced methods of mycobacterium genome differentiation and cooperation between scientists in the field of veterinary medicine and microbiology, have a profound meaning for understanding the phenomenon of bovine tuberculosis and its supervise its incidence. This is the first bacteriologically confirmed case of human infection of M. caprae in Poland.

Źródło:

Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 151-153
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 35.

Tytuł:

Prevalence of tuberculosis and drug-resistant tuberculosis in tertiary care rural hospital in Gujarat, India: a retrospective study

Autorzy:

Ughreja, Reena
Bhatt, Vaibhav
Shah, Sunny
Boxa, Devang

Powiązania:

https://bibliotekanauki.pl/articles/24987708.pdf

Data publikacji:

2023-12-11

Wydawca:

Gdański Uniwersytet Medyczny

Tematy:

Prevalence
Tuberculosis
Drug Resistance
Retrospective studies

Opis:

Background: A low prevalence of TB and MDR-TB was indicated from the retrospective study conducted at Pandit Dindayal Upadhyay Government Medical Hospital (PDUGMH) in Gujarat between 2018 and 2022. Mycobacterium tuberculosis causes tuberculosis (TB), the most lethal infectious disease in the world that affects people of all ages. Material and methods: From its TB & Chest Department, a total of 5,624 TB notification records were reviewed for the study, of which 5207 were TB positive, with 3586 (68.87%) males and 1621 (31.13%) females. Results: Amongst positive patients, 215 were diabetic, and 454 were HIV positive. Of 5207 TB-positive patients, 2982 (57.27%) had pulmonary TB. Extra Pulmonary TB showed the maximum number of patients with an infected lymph node. Age between 15 to 29 years was the leading affected age group, with a high peak in 2019. Drug resistance of Shorter Multidrug Resistance (RR-TB) was observed with a maximum of 0.8% (n = 42) patients and of Oral longer MDR/FQ with a minimum of 0.1% (n = 3) patients. Conclusions: Findings indicate that in these five years, patients treated at PDUGMH exhibited a tuberculosis prevalence of 92.59%, with a corresponding rate of multidrug-resistant TB standing at 1.48%. A comprehensive assessment is required to depict the burden and guide initiatives for eradication.

Źródło:

European Journal of Translational and Clinical Medicine; 2023, 6, 2; 36-44
2657-3148
2657-3156

Pojawia się w:

European Journal of Translational and Clinical Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 36.

Tytuł:

Najnowsze kierunki poszukiwań cząsteczek o aktywności przeciwprątkowej
Recent research of compounds with antitubercular activity

Autorzy:

Płoszaj, P.
Piwowar, A.
Ryng, S.

Powiązania:

https://bibliotekanauki.pl/articles/172240.pdf

Data publikacji:

2016

Wydawca:

Polskie Towarzystwo Chemiczne

Tematy:

gruźlica
związki przeciwprątkowe
lekoodporność prątków
badania kliniczne
tuberculosis
anti-tubercular compounds
drug-resistant tuberculosis
clinical tests

Opis:

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) remains a leading cause of morbidity and mortality in developing countries [1]. With the discovery of chemotherapeutic agents in the 1940s and implementation of directly- -observed therapy short course (DOTS) in the 1980s, it was believed that TB would decline globally. Although a declining trend was observed in most developed countries, this was not evident in other parts of the world [2]. In addition, the rate of successful treatment has been compromised in recent years due to the increasing prevalence of multidrug-resistant (MDR-) and extensively drug-resistant TB ( XDR-TB) strains [3]. Accordingly, significant efforts have been made to discover and develop new treatment modalities against TB. This article serves as a summary of the most recent developments in search for novel anti-tubercular compounds. Here we focus on reviewing the results of basic research and clinical trials obtained in 2015 including: a) the phase IV clinical trials conducted for newly developed: bedaquiline, delamanid, clofazimine (previously registered for treatment of leprosis) b) phase III for fixed-dose combination of existing drugs: pretomanid – moxifloxacin – pyrazinamide) and c) the phase II clinical trials for sutezolid, AZD5847 and SQ109 [4]. All newly developed compounds used in these studies have been briefly characterized and their synthesis pathways fully described. In addition we review the most recent and promising results on nicotinic acid hydrazides, thienyl-pirimidines imidazole- -thiadiazole-benzimidazole and benzocoumarine derivatives presenting their synthesis pathways, most active chemical structures and their potential applications. Throughout this paper the ultimate direction for new drug development strategies, in search for the anti-tubercular agents, have been reviewed.

Źródło:

Wiadomości Chemiczne; 2016, 70, 1-2; 35-56
0043-5104
2300-0295

Pojawia się w:

Wiadomości Chemiczne

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 37.

Tytuł:

Anti-tubercular substances produced by plants

Autorzy:

Polak, Żaneta
Kapka-Skrzypczak, Lucyna

Powiązania:

https://bibliotekanauki.pl/articles/972532.pdf

Data publikacji:

2017

Wydawca:

Instytut Medycyny Wsi

Tematy:

tuberculosis
endophytes
plant medicines
natural drugs
natural compounds

Opis:

Tuberculosis is one of the common causes of death worldwide, and according to the World Health Organization, in 2015, about 10.4 mln people globally is suffering from that disease. Despite great development in medicine and discovery of many antimycobacterial drugs, tuberculosis remains an unsolved problem. The populations of countries in Africa, Asia and South America have difficult access to hygiene, medical care and medicines, and they therefore resort to consulting traditional practitioners who mainly use drugs from natural sources which they prepare themselves. Plants are the biggest source of such medicines and are used as extracts, decoctions or powders, often without any evidence of their actual activity. Isolates from plants sometimes contain unknown substances or some second metabolites of microorganisms. In vitro studies have shown that some of these medicines have effective antimycobacterial properties, even against clinical, resistant strains. This is hopeful in the situation where more and more cases of tuberculosis prove to be resistant to standard drugs. Extracts of medicinal plants are often synergistic with synthetic drugs. Substances with insufficient MIC can be a basis for derivatives which have better properties. This thesis summarizes the current international knowledge of the use of plant substances used in the treatment of tuberculosis that could be potential new antituberculous drugs.

Źródło:

Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 147-152
1898-2395

Pojawia się w:

Journal of Pre-Clinical and Clinical Research

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 38.

Tytuł:

The disease and an immediate cause of death of Frederic Chopin
Na co chorował i co było przyczyną śmierci Fryderyka Chopina?

Autorzy:

Witt, Michał

Powiązania:

https://bibliotekanauki.pl/articles/2007011.pdf

Data publikacji:

2021

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

Frederic Chopin
cystic fibrosis
heart
pericarditis
tuberculosis

Opis:

Based on a visual analysis of the heart of Frederic Chopin performed in 2014 and described above, it can be stated with high probability that the composer suffered from a long lasting tuberculosis as a primary disease, which was the cause of progressive deterioration of his physical condition and numerous symptoms mainly from the respiratory tract. Tuberculous pericarditis rapidly progressing within a rather short period of time, a relatively rare complication of diffuse tuberculosis, might have been an immediate cause of death. This would aptly coincide with a startling opinion that in an autopsy picture the composer’s heart had been more affected by the disease than the lungs

Źródło:

Nauka; 2021, 2; 181-190
1231-8515

Pojawia się w:

Nauka

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 39.

Tytuł:

Mycobacterium tuberculosis - the 10 years of epidemiological and diagnostics studies

Autorzy:

Boruń-Popławska, Marta
Sajduda, Anna
Brzostek, Anna
Dziadek, Jarosław

Powiązania:

https://bibliotekanauki.pl/articles/764949.pdf

Data publikacji:

2005

Wydawca:

Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego

Tematy:

Mycobacterium tuberculosis
insertion sequences
PCR
epidemiology
diagnosis

Opis:

Tuberculosis (ТВ) is the main bacterial pathogen that causes more deaths than AIDS, malaria and all infectious diseases. The unusual long doubling time (about 24h), highly hydrophobic cell envelope resistant to chemical lysis was the reason to delay the molecular study of this bacteria. Fifteen years ago, we did not have any molecular tools and methods for genetic manipulation or isolation and analysis of intracellular protein and nucleic acids. Today we have many useful shuttle or integration vectors for basic study of mycobacteria. The full sequence of M. tuberculosis genome is already known. At the present time the diagnosis of tuberculosis is supported with fast-culture system BACTEC and molecular techniques based on PCR and DNA hybridization. The mechanisms of resistance to antituberculosis drugs were described, and first identification of resistance profile is available by using PCR and sequencing or real time PCR methods. In our group in the Center for Microbiology and Virology Polish Academy of Sciences and in the Dept, of Genetics of Microorganisms, University Łódź we have characterized new insertion sequences from M. tuberculosis complex- 18990 and IS1607. In diagnostic studies we have proposed the DIG-PCR ELISA assay as a reliable, specific and sensitive test to identify M. tuberculosis directly in clinical samples. We have performed wide epidemiological studies of M. tuberculosis strains isolated from Polish ТВ patients including drug - and multidrug - resistant strains. Finally we identified the most frequently present mutations responsible for drug resistance of polish clinical isolates of M. tuberculosis.

Źródło:

Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2005, 2
1730-2366
2083-8484

Pojawia się w:

Acta Universitatis Lodziensis. Folia Biologica et Oecologica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 40.

Tytuł:

All that fistulises is not Crohn’s disease: Multiple entero-enteric fistulae in intestinal tuberculosis

Autorzy:

Singh, Harjeet
Mandavdhare, Harshal
Sharma, Vishal

Powiązania:

https://bibliotekanauki.pl/articles/1392382.pdf

Data publikacji:

2019

Wydawca:

Index Copernicus International

Tematy:

intestinal tuberculosis
crohn’s disease
fistula
intestinal obstruction
surgery

Opis:

Abdominal tuberculosis is a common problem for clinicians in the tropical world and may manifest with varying clinical scenarios. Intestinal tuberculosis could have intestinal ulcers, strictures, hypertrophic lesions like polyps and may be complicated by perforation, bleeding, and intestinal obstruction. Crohn’s disease is an important differential of intestinal tuberculosis which is closely mimics intestinal tuberculosis in clinical, endoscopic, radiological and histological presentation. Crohn’s disease is known to have a fistulising variant. We report the case of 23 year old lady who had disseminated tuberculosis with intestinal involvement and seemed to improve on anti-tubercular therapy (ATT) but present with intestinal obstruction in the third month of ATT. Surgical exploration revealed clumping of bowel loops with multiple ileo-ileal fistulae. The case is presented because of the presence of entero-enteric fistulae and also because it demonstrated that intestinal tuberculosis may need surgical intervention even after initial improvement because of complications like intestinal obstruction.

Źródło:

Polish Journal of Surgery; 2019, 91, 1; 35-37
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 41.

Tytuł:

Suspicion of bovine tuberculosis in sheep in the Małopolskie Voivodeship (southern Poland)

Autorzy:

Didkowska, A.
Żmuda, P.
Orłowska, B.
Nowak, M.
Filip-Hutsch, K.
Cuper, K.
Krajewska-Wędzina, M.
Anusz, K.

Powiązania:

https://bibliotekanauki.pl/articles/16539333.pdf

Data publikacji:

2022

Wydawca:

Polska Akademia Nauk. Czasopisma i Monografie PAN

Tematy:

bovine tuberculosis
dairy products
IGRA
sheep
tuberculin skin test

Opis:

Bovine tuberculosis (BTB) in sheep (Ovis aries) is caused by Mycobacterium bovis and Mycobacterium caprae. Even though sheep have been considered less sensitive to BTB than other ruminants, they have been subject to increasing numbers of tuberculosis cases and it has been suggested that they may act as a disease reservoir in some regions. Aim of the study: Following a report of tuberculous-like gross lesions (repeated cases of purulent or caseous lymphadenitis and a single case of serosal tubercles on the peritoneum) from veterinarians working in a slaughterhouse in the Małopolskie Voivodeship, southern Poland, the aim of this study was to conduct ante-mortem BTB diagnostics in three flocks with suspected BTB. The animals for testing were selected randomly from the flocks; a blood sample for interferon-γ release assay (IGRA) and a single tuberculin skin test (TST) was performed on each sheep. All TST results were negative. The IGRA result was positive in two ewes from the same flock (four and five years of age); these two sheep were tested microbiologically using Stonebrink and Löwenstein-Jensen media. No gross lesions suggesting BTB were observed, and the culture results were negative. Based on the positive IGRA results, together with its high specificity in sheep, and the potential risk to humans posed by consuming local unpasteurized dairy products, we recommend introducing serological BTB screening in sheep from this area, and subjecting the positive results to confirmation by culture.

Źródło:

Polish Journal of Veterinary Sciences; 2022, 25, 3; 469-473
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 42.

Tytuł:

A study on the mycobacterial burden and phenotypic drug resistance pattern with reference to the GeneXpert Cycle Threshold values in pulmonary tuberculosis

Autorzy:

Kashyap, Bineeta
Sarkar, Krishna
Singh, Kapil
Hyanki, Puneeta

Powiązania:

https://bibliotekanauki.pl/articles/29520459.pdf

Data publikacji:

2023-12-31

Wydawca:

Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego

Tematy:

CBNAAT
cycle threshold values
rifampicin resistance
smear microscopy
tuberculosis

Opis:

Introduction and aim. Tuberculosis (TB) remains a significant global health challenge. Early and accurate diagnosis is crucial to prevent further transmission. The present study aimed to correlate cycle threshold values with smear microscopy and culture positivity, and determine cut-off cycle threshold values for levels of smear grade and culture positivity. Material and methods. Forty presumptive cases of pulmonary TB were included and subjected to Ziehl-Neelsen stain, culture on Lowenstein Jensen media, CBNAAT and drug susceptibility testing for first line anti-tubercular drugs. Results. Our study predicts 3+, 2+, and 1+ sputum smear grade at a cut-off of Ct value ≤ 16.74, ≤19.68, and ≤ 22.32 respectively. A strong positive correlation was found between time to culture positivity and Ct value. A cut-off of Ct value ≤22.32 predicts culture positivity with a sensitivity of 92%, and a specificity of 67%. None of the isolates showed rifampicin resistance by 1% proportion method. Conclusion. Understanding the appropriate utilization of CBNAAT Ct values and their correlation with smear microscopy grade, culture, and drug susceptibility testing can assist clinicians in early identification and prompt initiation of appropriate treatment. This knowledge can contribute to the prevention of drug resistance, reduced transmission, and a decreased disease burden associated with TB.

Źródło:

European Journal of Clinical and Experimental Medicine; 2023, 4; 730-735
2544-2406
2544-1361

Pojawia się w:

European Journal of Clinical and Experimental Medicine

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 43.

Tytuł:

Bovine tuberculosis outbreak in farmed American bison (Bison bison) in Poland

Autorzy:

Krajewska-Wędzina, M.
Olech, W.
Kozińska, M.
Augustynowicz-Kopeć, E.
Weiner, M.
Szulowski, K.

Powiązania:

https://bibliotekanauki.pl/articles/2087860.pdf

Data publikacji:

2017

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

Mycobacterium caprae
bovine tuberculosis
bison (Bison bison)
epidemiology

Źródło:

Polish Journal of Veterinary Sciences; 2017, 4; 819-821
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 44.

Tytuł:

Identification of proteins associated with Mycobacterium tuberculosis virulence pathway by their polar profile

Autorzy:

Polanco, Carlos
Castañón-González, Jorge
Mancilla, Raul
Buhse, Thomas
Samaniego, José
Gimbel, Arturo

Powiązania:

https://bibliotekanauki.pl/articles/1039087.pdf

Data publikacji:

2015

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Mycobacterium tuberculosis bacteria virulence pathway
Polarity Index Method

Opis:

With almost one third of the world population infected, tuberculosis is one of the most devastating diseases worldwide and it is a major threat to any healthcare system. With the mathematical-computational method named "Polarity Index Method", already published by this group, we identified, with high accuracy (70%), proteins related to Mycobacterium tuberculosis bacteria virulence pathway from the Tuberculist Database. The test considered the totality of proteins cataloged in the main domains: fungi, bacteria, and viruses from three databases: Antimicrobial Peptide Database (APD2), Tuberculist Database, Uniprot Database, and four antigens of Mycobacterium tuberculosis: PstS-1, 38-kDa, 19-kDa, and H37Rv ORF. The method described was calibrated with each database to achieve the same performance, showing a high percentage of coincidence in the identification of proteins associated with Mycobacterium tuberculosis bacteria virulence pathway located in the Tuberculist Database, and identifying a polar pattern regardless of the group studied. This method has already been used in the identification of diverse groups of proteins and peptides, showing that it is an effective discriminant. Its metric considers only one physico-chemical property, i.e. polarity.

Źródło:

Acta Biochimica Polonica; 2015, 62, 2; 191-196
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 45.

Tytuł:

Unfinished first-line tuberculosis treatment in primary care in Indonesia

Autorzy:

Asyary, Al
Mahendradhata, Yodi

Powiązania:

https://bibliotekanauki.pl/articles/552420.pdf

Data publikacji:

2019

Wydawca:

Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych

Tematy:

tuberculosis
drug resistance
Indonesia
developing countries
primary care.

Opis:

Background. Unfinished tuberculosis (TB) treatment has slowly but surely become an unexpected event in the disease’s development into drug-resistant TB. Developing countries, mostly comprised of Asian and Eastern European countries, including Indonesia, have been overwhelmed in preventing drug-resistant TB outcomes and have also failed to avoid the development of this disease. Objectives. This review discusses the current issue of an unfinished first-line TB treatment strategy in primary care in Indonesia, presenting some relevant strategies in developing countries. Material and methods. A narrative review approach conducted on all existing evidence in selected scientific bibliographic sources. The researchers defined the keywords based on the research question as a search strategy. Results. Scarce resources and limited access, alongside national policy on TB control and management, contribute in different ways to impede first-line TB treatment in Indonesia. Empowerment of TB patients and their families are considered the best ways to increase awareness on TB medication in a low- to middle-income setting. The role of the hospital and private practitioner networks in the treatment and management of TB patients is essential for developing active-case-finding-approach programs for TB suspects in primary care in an Indonesian setting. Contrarily, the potential misunderstandings in TB treatment have led to peculiar events affected by poor surveillance systems for TB investigation contacts to prevent TB incidences in large populations. Conclusions. This study addressed the barrier of all stakeholders, particularly primary care, to achieve the Indonesian government’s goals of TB elimination by 2030 and zero TB findings by 2050

Źródło:

Family Medicine & Primary Care Review; 2019, 2; 185-188
1734-3402

Pojawia się w:

Family Medicine & Primary Care Review

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 46.

Tytuł:

Adenozyno-5’-o-(n-acylosulfamoilowe) pochodne jako potencjalne leki przeciwgruźlicze
5’-o-[n-(acyl)sulfamoyl]adenosine derivatives as potential antituberculosis drugs

Autorzy:

Kulik, K.
Baraniak, J.

Powiązania:

https://bibliotekanauki.pl/articles/172072.pdf

Data publikacji:

2016

Wydawca:

Polskie Towarzystwo Chemiczne

Tematy:

leki przeciwgruźlicze
prątek gruźlicy
acyloadenylany
antituberculosis drugs
Mycobacterium tuberculosis
acyladenylates

Opis:

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is the leading bacterial cause of infectious disease mortality. The current WHOapproved treatment for TB involves a three- or four-drug regimen comprising isoniazid, rifampin, pyrazinamide, and/or ethambutol for a minimum of 6 months. While these first-line agents remain useful in treating susceptible Mycobacterium tuberculosis strains, the emergence of multidrug resistant tuberculosis demands the development of new drugs [1]. Iron acquisition is an essential process for M. tuberculosis as well as almost all other microorganisms. However, this essential micronutrient is highly sequestered in a mammalian host. In response to iron starvation, Mtb produces small-molecule iron chelators, a pair of related peptidic siderophores known as mycobactin and carboxymycobactins that vary by the appended lipid residue termed siderophores [4, 5, 7, 8]. Because mycobactins are critical for growth and virulence of M. tuberculosis, they have emerged as attractive targets for the development of anti-TB agents [4]. Biosynthesis of mycobactin is initiated by the aryl acid adenylation enzyme MbtA which activates salicylic acid forming an acyladenylate intermediate (Sal- AMP). MbtA is also responsible for loading the acyladenylate intermediate onto the thiolation domain of MbtB-SH – the enzyme taking part in the next step of biosynthesis process [10]. Given the documented importance of many siderophores for virulence and lack of human aryl acid adenylation enzymes homologues, several analogues possessing stable linkers as bioisosteres of the labile acyl phosphate function have been synthesized as the potent enzyme inhibitors [13]. The initial lead compound 5’-O-[N- (salicyl)sulfamoyl]adenosine (Sal-AMS) has emerged as a promising inhibitor of MbtA and was shown to possess promising whole-cell activity toward M. tuberculosis.

Źródło:

Wiadomości Chemiczne; 2016, 70, 7-8; 455-472
0043-5104
2300-0295

Pojawia się w:

Wiadomości Chemiczne

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 47.

Tytuł:

Tuberculosis as a public health problem in the World and in Slovakia
Gruźlica jako problem zdrowia publicznego całego świata, także Słowacji

Autorzy:

Salat, D.
Beno, P.

Powiązania:

https://bibliotekanauki.pl/articles/271410.pdf

Data publikacji:

2012

Wydawca:

Górnośląska Wyższa Szkoła Pedagogiczna im. Kardynała Augusta Hlonda

Tematy:

gruźlica
MDR-TB
XDR-TB
leki przeciwgruźlicze
tuberculosis
antituberculosis drugs

Opis:

Tuberculosis (TB) remains the most frequent and important infectious disease causing morbidity and death worldwide. An estimated one third of the world's population is infected with Mycobacterium tuberculosis. The World Health Organization estimates that about eight to ten million new TB cases occur annually around the globe. TB is in the top three, with malaria and HIV as being the leading causes of death from a single infectious agent, and approximately 1.7 to 2 million deaths are attributable to TB annually. Widespread global use/misuse of isoniazid and rifampicin over three decades has resulted in the emergence of the ominous spread of multi-drug-resistant TB (MDR-TB) and extensively drugresistant TB (XDR-TB). MDR-TB is defined as TB that is resistant to the two most effective first-line therapeutic drugs available, isoniazid and rifampicin. In addition, virtually untreatable strains of M. tuberculosis are emerging globally. XDR-TB is defined as MDR-TB that also is resistant to the most effective second-line therapeutic drugs used commonly to treat MDR-TB: fluoroquinolones and to at least one of three injectable second-line drugs used to treat TB (amikacin, kanamycin, or capreomycin). Unfortunately, no new drugs besides rifabutin and rifapentine have been marketed for TB in the US and other countries in the 40 years since the release of rifampicin. There are a number of constraints that have deterred companies from investing in new anti-TB drugs. The research is expensive, slow and difficult, and requires specialized facilities. Development time of any anti-TB drug will be long (clinical trials will require a minimum six-month therapy, with a follow-up period of one year or more). It is hard to demonstrate the obvious benefits of new anti-TB agents over pre-existing drugs, since clinical trials involve multi-drug combination therapy using highly effective ordinary anti-TB drugs. XDR-TB has been identified in all regions of the world, including the United States. These difficult to treat resistant forms of TB are increasingly seen in Asia, Eastern Europe, South America and sub-Saharan Africa, disrupting TB and HIV control programmes. Because of the limited responsiveness of XDR-TB to available antibiotics, mortality rates among patients with XDR-TB are similar to those of TB patients in the pre-antibiotic era. To assess the frequency and distribution of XDR-TB cases, the CDC and WHO surveyed an international network of TB laboratories. Slovakia belongs to a group of countries with low incidence rates of TB. HIV-infected patients with MDR-TB have unacceptably high mortality; both antiretroviral and antimycobacterial treatment are necessary. Simultaneous treatment requires 6-10 different drugs. Given the increasing current global trends in MDR-TB, aggressive preventive and management strategies are urgently required to avoid disruption of global TB control efforts. Available data suggest that existing interventions, public health systems and anti-TB and anti-HIV programmes must be strengthened significantly.
Na całym świecie gruźlica (TB) nadal pozostaje najczęstszą i najbardziej znaczącą chorobą zakaźną, powodującą zachorowania i zgony. Ocenia się, że jedna trzecia światowej populacji jest zarażona prątkiem gruźlicy. Według światowej Organizacji Zdrowia pojawia się co roku na całym świecie osiem do dziesięciu milionów nowych zachorowań na gruźlicę. Gruźlica obok malarii i HIV znajduje się w pierwszej trójce najczęstszych przyczyn zgonów spowodowanych pojedynczym czynnikiem zakaźnym. Przypisuje się jej około 1,7 do 2 milionów zgonów rocznie. Powszechne stosowanie i nadużywanie izoniazydu i rifampicyny przez trzy dekady doprowadziły do powstania i rozprzestrzenienia się wielolekowo opornej odmiany gruźlicy (MDR-TB) i szerokoodpornej gruźlicy (XDR-TB) na całym świecie. MDR-TB jest definiowana jako ta odmiana gruźlicy, która jest odporna na dwa najbardziej efektywne leki pierwszorzutowe, tj. izoniazyd i rifampicynę. Dodatkowo, niemal nieuleczalne odmiany MDR-TB tworzą się na całym świecie. XDR-TB jest definiowana jako ta odmiana MDR-TB, która dodatkowo jest odporna na najbardziej efektywny lek drugiego rzutu w terapii MDR-TB, tj. fluorochinolony i przynajmniej na jeden z trzech leków podawanych pozajelitowo, tj. amikacynę, kanamycynę lub kapreomycynę. Niestety żadne nowe lekarstwa oprócz rifabutinu i rifapentinu nie zostały wprowadzone na rynek w Stanach Zjednoczonych i w innych krajach w czterdziestoletnim okresie po wprowadzeniu rifampicyny. Jest szereg ograniczeń, które odstraszały koncerny farmaceutyczne przed inwestowaniem w nowe leki przeciwko gruźlicy. Badania są drogie, długotrwałe i żmudne. Wymagają ponadto specjalistycznych ośrodków badawczych. Czas opracowania jakiegokolwiek leku przeciwko gruźlicy jest bardzo długi (badania kliniczne trwać muszą przynajmniej pół roku, z rocznym okresem następującym). Jest niezwykle trudno wykazać istotną przewagę nowych leków przeciwgruźliczych nad tymi już istniejącymi, gdyż badania kliniczne opierają się na porównaniu do wcześniejszej terapii, często obejmującej wiele tradycyjnych środków przeciwko gruźlicy, których skuteczność była duża. XDR-TB rozpoznawano we wszystkich regionach świata, w tym w Stanach Zjednoczonych. Te trudne do wyleczenia odporne formy gruźlicy są coraz częściej odnotowywane w Azji, Europie Wschodniej, Ameryce Południowej i na terenach Afryki Subsaharyjskie, zakłócając działalność programów kontroli gruźlicy i HIV. Z powodu ograniczonej reakcji XDR-TB na dostępne antybiotyki, śmiertelność pacjentów z XDR-TB porównywalna jest do tej, którą pacjenci z gruźlicą wykazywali w erze przedantybiotykowej. Aby ocenić rozmieszczenie i częstotliwość przypadków XDR-TB, Centrum Zapobiegania i Zwalczania Chorób (CDC) oraz Światowa Organizacja Zdrowia (WHO) powołały międzynarodową sieć laboratoriów gruźliczych. Słowacja należy do krajów z niską zachorowalnością na gruźlicę. Pacjenci zarażeni wirusem HIV cierpiący na MDR-TB wykazują nieakceptowalną śmiertelność: obie terapie są konieczne: antyretrowirusowa i antyprątkowa. Symultaniczne leczenie wymaga zastosowania 6-10 różnych lekarstw. Biorąc pod uwagę wzrastającą liczbę zachorowań na MDR-TB, zdecydowane strategie prewencyjne i zarządzające są niezwłocznie konieczne, aby nie doszło do zaburzenia działań na rzecz kontroli gruźlicy na całym świecie. Dostępne źródła sugerują, że istniejące działania, systemy zdrowia publicznego i programy przeciwdziałania HIV i gruźlicy muszą zostać znacząco wzmocnione.

Źródło:

Journal of Ecology and Health; 2012, R. 16, nr 1, 1; 21-27
2082-2634

Pojawia się w:

Journal of Ecology and Health

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 48.

Tytuł:

Simple discrete SIS criss-cross model of tuberculosis in heterogeneous population of homeless and non-homeless people
Dyskretny krzy»owy model rozprzestrzeniania się gruźlicy w niejednorodnej populacji bezdomnych i niebezdomnych

Autorzy:

Bodzioch, Mariusz
Choiński, Marcin

Powiązania:

https://bibliotekanauki.pl/articles/953421.pdf

Data publikacji:

2019

Wydawca:

Polskie Towarzystwo Matematyczne

Tematy:

tuberculosis
discretization
explicit euler method
discrete
dynamical system
local stability

Opis:

Zaproponowany został dyskretny krzyżowy model rozprzestrzeniania się gruźlicy w niejednorodnej populacji składającej się z bezdomnych i niebezdomnych. Model ten oparty jest na prostym modelu typu SIS z dwuliniową funkcją transmisji i stałym napływem w obu populacjach. Przeprowadzona została wstępna analiza stabilności stanów stacjonarnych. Pokazano, że aby kontrolować rozprzestrzenianie się choroby zakaźnej w niejednorodnej populacji nie jest wystarczające rozważanie dynamiki choroby w kżdej podpopulacji oddzielnie. Parametry modelu zostały dopasowane do danych z województwa warmińsko-mazurskiego.
In this paper we propose a discrete criss-cross model of tuberculosis (TB) transmission in a heterogeneous population, which consists of two different subpopulations: homeless and non-homeless people. This criss-cross model is based on the simple continuous SIS model with bilinear transmission function and constant inflow into both subpopulations considered previously by us. We make preliminary stability analysis. We show that to control the spread of the infectious disease in a heterogeneous population it is not enough to consider the dynamics of the disease in each subpopulation separately. This result is consistent with the result for continuous model. We also fit the model to epidemic data from Warmian-Masurian Province of Poland.

Źródło:

Mathematica Applicanda; 2019, 47, 1
1730-2668
2299-4009

Pojawia się w:

Mathematica Applicanda

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 49.

Tytuł:

Ciało fortepianu – artykulacja doświadczenia cielesnego w korespondencji Fryderyka Chopina
The Body of the Piano – the Articulation of a Physical Experience in Frédéric Chopin’s Letters

Autorzy:

Świtka, Aleksandra

Powiązania:

https://bibliotekanauki.pl/articles/2038275.pdf

Data publikacji:

2021-12-29

Wydawca:

Uniwersytet im. Adama Mickiewicza w Poznaniu

Tematy:

Frédéric Chopin
physicality
body
physical subjectivity
tuberculosis
correspondence
music
romanticism

Opis:

The article focuses on the presentation and analysis of selected excerpts from Frédéric Chopin’s letters from the 1824-1849 period that illustrate their author’s attitude towards physical experiences. In contrast to the “disembodied” reception of the artist that reproduces the “soul of the piano” metaphor, the article describes a broad representation of the composer’s texts on physical appearance, the role of the body in the performance act, living through illness and the oncoming death. The cross-sectional and chronologically ordered study presented in the article shows the evolution of the subject’s attitude towards his own body along the progress of his illness. It is at the same time an illustration of the style and imagery used by the author of the letters while describing specific aspects of physical experience.

Źródło:

Poznańskie Studia Polonistyczne. Seria Literacka; 2021, 41; 15-38
1233-8680
2450-4947

Pojawia się w:

Poznańskie Studia Polonistyczne. Seria Literacka

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 50.

Tytuł:

Comparing the performance of QuantiFERON-TB Gold and Mantoux test in detecting latent tuberculosis infection among Iranian health care workers

Autorzy:

Talebi-Taher, Mahshid
Javad-Moosavi, Seied-Ali
Entezari, Amir-Hossein
Shekarabi, Mehdi
Parhizkar, Baran

Powiązania:

https://bibliotekanauki.pl/articles/2185374.pdf

Data publikacji:

2011-12-01

Wydawca:

Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi

Tematy:

QuantiFERON-TB Gold
mantoux test
latent tuberculosis infection
Health care workers

Opis:

Objectives: The risk of transmission of Mycobacterium tuberculosis from patients with tuberculosis to health care workers (HCWs) has been well documented but little is known about the prevalence of latent tuberculosis infection (LTBI) in Iranian HCWs. The aim of this study was to determine the prevalence of LTBI among HCWs by using IFNgamma-release assay and compare the results with those of tuberculin skin test (TST). Methods: Two hundred HCWs were evaluated with both TST and QuantiFERON-TB Gold In Tube test (QFT-GIT). The obtained data were analyzed by SPSS v.16 Software. Results: The participants were 73 males and 127 females with the mean age of 34.36±8.26 years. TST was positive in 105 cases (52.5%) and the QFT results were positive in 17 cases (8.5%). There was poor agreement between the two tests (53%, к = 0.115). Induration diameter of TST ≥ 10 mm and working duration ≥ 10 years were independent predictors for positive QFT (p = 0.004). Conclusions: Due to the fact that BCG vaccination has been administered routinely to all HCWs in Iran, specifi c tests should be introduced for high risk groups. QFT thus seems to be more effective for LTBI diagnosis than TST among HCWs with BCG immunization history.

Źródło:

International Journal of Occupational Medicine and Environmental Health; 2011, 24, 4; 359-366
1232-1087
1896-494X

Pojawia się w:

International Journal of Occupational Medicine and Environmental Health

Dostawca treści:

Biblioteka Nauki

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