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Wyświetlanie 1-15 z 52
Tytuł:
Achieving high dependability of an endoscopy recommender system (ERS)
Autorzy:
Zieliński, J.
Krawczyk, H.
Powiązania:
https://bibliotekanauki.pl/articles/1965771.pdf
Data publikacji:
2004
Wydawca:
Politechnika Gdańska
Tematy:
telemedicine
security
dependability
replication
Opis:
The paper presents a strategy for achieving high dependability of a computer-based system devoted to endoscopic examination (ERS). Two levels of replication are used: hardware (3 computers) and database (redundant copies). Archivisation of documents describing patient examinations and films made during such examinations is described. The influence of the used techniques on performance and dependability of the replicated system is estimated.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2004, 8, 2; 237-242
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activities of human telomerase in cancer development, detection and therapeutics - A Review
Autorzy:
Pal, Partha
Ray, Spandita
De (Dutta), Koly
Powiązania:
https://bibliotekanauki.pl/articles/1190141.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Chromosomes
End-replication
Telomere
Telomerase
Cancer
Therapeutic
Opis:
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, which are essential for maintaining the stability of the linear eukaryotic chromosomes. Progressive telomere shortening is an inevitable occurrence in normal somatic cells due to the end-replication problem leading to limited replication efficiency. The hallmark characteristics of human cancer cells include infinite reproductive potential, uncontrolled proliferation and immortality. These abilities of transformed cancerous cells are mainly due to the maintenance of their telomeres since degradation of chromosomal telomeric ends leads to cellular senescence or death. Thus telomere biology is important in the study of human cancer development. The mechanism by virtue the cancer cells are able to divide indefinitely is by maintaining telomeres. Activity of telomerase, a telomere-elongating ribonucleoprotein reverse transcriptase enzyme, is responsible for inducing the property of immortality to cancer cells. In humans nearly about 80% to 90% cancer cells activate telomerase and elongate their telomeres to overcome the end-replication problem. Telomere shortening suppresses cancer formation in contrast according to certain reports it sometimes promotes genomic instability which leads to enhancement of carcinogenesis and consequently the development of malignancy. Majority of cancer cells activate telomerase, but it remains mysterious as to find the reasons of the fact that certain cancer cells often show shorter telomeres in comparison to the cells in the surrounding normal tissues. This controversial role of telomerase associated with certain transformed cells leading to the cancerous state in relation to its role in normal cells is an interesting field to study which points out to the fact of development of cancer cells targeting drugs based on telomerase activities as an alternative weapon in combating against this dreaded human disease. The present review focuses on the activity of telomerase in telomere maintenance in the development of cancerous cells in humans, the use of telomerase as an assay technique for cancer detection as well as the anti-cancer therapeutic approach of targeting the telomerase in the current era of treatment of human cancer.
Źródło:
World Scientific News; 2016, 42; 87-100
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antiviral Activities of Cu2+ Ions in Viral Prevention, Replication, RNA Degradation, and for Antiviral Efficacies of Lytic Virus, ROS-Mediated Virus, Copper Chelation
Autorzy:
Ishida, Tsuneo
Powiązania:
https://bibliotekanauki.pl/articles/1177808.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Capsid protein
Copper chelation
Copper homeostasis
Copper oxide nanoparticles
Cu2+ and Cu1+ ions
DNA/RNA virus
HSV
ROS
Viral replication
mRNA degradation or decay
Opis:
Copper has been known for decades that marked changes of micronutrient homeostasis in the host are accompanied by infection or inflammation. Copper levels in the serum are significantly elevated in response to inflammation that copper accumulates at sites of inflammation. Easily oxidized copper oxide nanoparticles (CuONPs) are widely used as catalysts that the ability of CuONPs to reduce bacterial population and virus application is enhanced. The mechanism of copper-mediated inactivation of herpes simplex virus (HSV) is by which cupric ions oxidatively damage biomolecules. Virus-mediated subjugation and modulation of host lipids during infection that the life cycle of most viruses proceeds through a series of basic steps: binding and internalization, fusion, uncoating, of the viral genome, its replication, assembly of new particles, and budding or release of the newly made viruses. The HIV-1 protein Vpu is an 81-amino-acid (16-kDa) type I which the presence of Vpu leads to the degradation of BST-2 via an endosome-lysosome degradation pathway. Oxidative degradation by a Cu-metalloenzyme, and ubiquitin-mediated degradation of cellular proteins were exploited. Copper can disrupt the lytic cycle of the Coccolithovirus. Lysins represent a novel class of anti-infectives derived from bacteriophage which lysins are bacterial cell wall hydrolytic enzymes that selectively and rapidly kill specific bacteria. Regarding copper induced cellular toxicity, several mechanisms have been proposed based on the formations of ROS by free Cu ions as cupric and cuprous ions can participate in redox reactions. ROS (O2ˉ,･OH, OHˉ), Cu+ and H2O2 play the important roles for viral inactivations. Thujaplicin-copper chelates inhibit influenza virus-induced apoptosis. Pyrrolidine dithiocarbamate as a metal ion binding agent inhibits the activity of the viral proteases of polyprotein processing and RNA replication of HRV. Chelation enables metals are capable of ligand scavenging via complexation, since reverse transcriptase enzyme inhibits the growth and replication of RNA tumor viruses. Thus, copper complex and copper chelation enhance antiviral efficacy.
Źródło:
World Scientific News; 2018, 99; 148-168
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antiviral Activities of Zn2+ Ions for Viral Prevention, Replication, Capsid Protein in Intracellular Proliferation of Viruses
Autorzy:
Ishida, Tsuneo
Powiązania:
https://bibliotekanauki.pl/articles/1177895.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Capsid protein
DNA/RNA virus
HIV
RNA degradation
ROS
Replication
Zinc finger
Opis:
In zinc homeostasis, zinc transporters ZIP and ZnT show tissue specificity and developmental and stimulus responsive expression patterns. The course of the life cycles of viral infections is governed by complex interactions between the virus and the host cellular system. Viruses depend on a host cell for their protein synthesis that the virus must first bind to the host cell, and then the virus enters in the cytoplasm which the genome is liberated from the protective capsid and, either in the nucleus or in the cytoplasm. The use of cellular zinc metalloproteases is effective for virus entry and coronavirus fusion. Molecular aspects of dengue virus genome uncoating and the fate of the capsid protein and RNA genome early during infection were investigated and found that capsid is degraded after viral internalization by the host ubiquitin-proteasome system. These results provide the first insights for antiviral intervention into dengue virus uncoating by Zn-binding degradation and enzyme inhibition of nucleocapsid, capsid protein, viral genome. AZPs inhibit virus DNA replication. Increasing the intracellular Zn2+ concentration with zinc-ionophores like pyrithione can efficiently impair the replication of a variety of RNA viruses, including poliovirus and influenza virus. ZAP is a host antiviral factor that specifically inhibit the replication of certain viruses, including HIV-1, Sindbis virus, and Ebola virus. ZAP specifically binds to the viral mRNA and recruits the cellular RNA degradation machinery to degrade the target RNA, while molecular mechanism by which ZAP inhibits target RNA expression and regulation of antiviral activity have been remained unclear. ROS as byproducts play an important role in cell signaling and regulate hormone action, growth factors, cytokines, transcription, apoptosis, iron transport, immunomodulation, and neuromodulation which many retroviruses, DNA and RNA viruses can cause cell death by generating oxidative stress in infected cells.
Źródło:
World Scientific News; 2018, 97; 28-50
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Asymmetry of nucleotide composition of prokaryotic chromosomes
Autorzy:
Mackiewicz, P
Gierlik, A.
Kowalczuk, M.
Dudek, M.R.
Cebrat, S.
Powiązania:
https://bibliotekanauki.pl/articles/2043862.pdf
Data publikacji:
1999
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
chromosome
DNA asymmetry
prokaryotic chromosome
Escherichia coli
Borrelia burgdorferi
Bacillus subtilis
Treponema pallidum
nucleotide composition
asymmetrical replication
Źródło:
Journal of Applied Genetics; 1999, 40, 1; 1-14
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bacterial chromosome segregation.
Autorzy:
Bartosik, Aneta
Jagura-Burdzy, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1041457.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
proteins engaged in chromosome partitioning
sister cohesion model
bacterial cell cycle
factory model
chromosome replication and segregation
Opis:
In most bacteria two vital processes of the cell cycle: DNA replication and chromosome segregation overlap temporally. The action of replication machinery in a fixed location in the cell leads to the duplication of oriC regions, their rapid separation to the opposite halves of the cell and the duplicated chromosomes gradually moving to the same locations prior to cell division. Numerous proteins are implicated in co-replicational DNA segregation and they will be characterized in this review. The proteins SeqA, SMC/MukB, MinCDE, MreB/Mbl, RacA, FtsK/SpoIIIE playing different roles in bacterial cells are also involved in chromosome segregation. The chromosomally encoded ParAB homologs of active partitioning proteins of low-copy number plasmids are also players, not always indispensable, in the segregation of bacterial chromosomes.
Źródło:
Acta Biochimica Polonica; 2005, 52, 1; 1-34
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bacterial DNA repair genes and their eukaryotic homologues: 5. The role of recombination in DNA repair and genome stability
Autorzy:
Nowosielska, Anetta
Powiązania:
https://bibliotekanauki.pl/articles/1040931.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
homologous recombination
Escherichia coli
DSB
replication forks
DNA repair
Opis:
Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Repair by homologous recombination is generally accurate as it uses undamaged homologous DNA molecule as a repair template. In Escherichia coli homologous recombination repairs both the double-strand breaks and single-strand gaps in DNA. DNA double-strand breaks (DSB) can be induced upon exposure to exogenous sources such as ionizing radiation or endogenous DNA-damaging agents including reactive oxygen species (ROS) as well as during natural biological processes like conjugation. However, the bulk of double strand breaks are formed during replication fork collapse encountering an unrepaired single strand gap in DNA. Under such circumstances DNA replication on the damaged template can be resumed only if supported by homologous recombination. This functional cooperation of homologous recombination with replication machinery enables successful completion of genome duplication and faithful transmission of genetic material to a daughter cell. In eukaryotes, homologous recombination is also involved in essential biological processes such as preservation of genome integrity, DNA damage checkpoint activation, DNA damage repair, DNA replication, mating type switching, transposition, immune system development and meiosis. When unregulated, recombination can lead to genome instability and carcinogenesis.
Źródło:
Acta Biochimica Polonica; 2007, 54, 3; 483-494
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Charakterystyka podstawowych typów zapasowych ośrodków przetwarzania danych
Characteristics of basic types of alternate sites
Autorzy:
Liderman, K.
Powiązania:
https://bibliotekanauki.pl/articles/273179.pdf
Data publikacji:
2009
Wydawca:
Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
Tematy:
odtworzenie systemu i danych po katastrofie
lokalizacja zapasowa
ciągłość działania
replikacja danych
RTO
RPO
RTA
NRO
disaster recovery
alternate site
continuity
data replication
Opis:
Artykuł zawiera przegląd i charakterystykę podstawowych typów ośrodków zapasowych, ze szczególnym uwzględnieniem przeznaczonych do replikacji danych. Opisano także podstawowe sposoby zwiększania odporności systemu teleinformatycznego i danych na skutki katastrof.
This paper presents basic types of alternate sites (especially dedicated to data replication) and their characteristics. Basic methods of increasing computer systems and data immunity against disaster consequences are also described.
Źródło:
Biuletyn Instytutu Automatyki i Robotyki; 2009, R. 15, nr 26, 26; 3-28
1427-3578
Pojawia się w:
Biuletyn Instytutu Automatyki i Robotyki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coronaviruses fusion with the membrane and entry to the host cell
Autorzy:
Wędrowska, E.
Wandtke, T.
Senderek, T.
Piskorska, E.
Kopiński, P.
Powiązania:
https://bibliotekanauki.pl/articles/2085559.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
coronavirus
spike protein
membrane fusion
viral entry
nonstructural proteins
replication complex
Opis:
Introduction. Coronaviruses (CoVs) are positive-strand RNA viruses with the largest genome among all RNA viruses. They are able to infect many host, such as mammals or birds. Whereas CoVs were identified 1930s, they became known again in 2003 as the agents of the Severe Acute Respiratory Syndrome (SARS). The spike protein is thought to be essential in the process of CoVs entry, because it is associated with the binding to the receptor on the host cell. It is also involved in cell tropism and pathogenesis. Receptor recognition is the crucial step in the infection. CoVs are able to bind a variety of receptors, although the selection of receptor remains unclear. Coronaviruses were initially believed to enter cells by fusion with the plasma membrane. Further studies demonstrated that many of them involve endocytosis through clathrin-dependent, caveolae-dependent, clathrin-independent, as well as caveolae-independent mechanisms. Objectives. The aim of this review is to summarise current knowledge about coronaviruses, focussing especially on CoVs entry into the host cell. Advances in understanding coronaviruses replication strategy and the functioning of the replicative structures are also highlighted. The development of host-directed antiviral therapy seems to be a promising way to treat infections with SARS-CoV or other pathogenic coronaviruses. There is still much to be discovered in the inventory of pro-and anti-viral host factors relevant for CoVs replication. The latest pandemic danger, originating from China, has given our previously prepared work even more of topicality.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 175-183
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Creative industries and knowledge replication
Autorzy:
Łukasik, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/419668.pdf
Data publikacji:
2019
Wydawca:
Wydawnictwo Uniwersytetu Ekonomicznego we Wrocławiu
Tematy:
creative industries
management
knowledge replication
Opis:
The concept of creative industries is becoming popular in recent years. Therefore, many publications deal with this topic. Nevertheless, fewer of them are dedicated to managerial issues. Most publications concentrate on the scope of creative industries and their influence on economy and society. The first aim of this paper is to present the specificity of management of organization in creative industry and its activity. The second aim is to collect and cite different definitions of knowledge replication to explain the meaning of the notion of knowledge replication. The third aim is to show the role of knowledge replication for organization’s activity in creative industries. The article also contains an introduction concerning different approaches to definition and classification of creative industries.
Źródło:
Nauki o Zarządzaniu; 2019, 24, 3; 10-15
2080-6000
Pojawia się w:
Nauki o Zarządzaniu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Database Replication for Disconnected Operations with Quasi Real-Time Synchronization
Autorzy:
Mucha, Rafał
Baliś, Bartosz
Grigoras, Costin
Kitowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/27312921.pdf
Data publikacji:
2023
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
multi-primary database replication
Bucardo
EDB Replication Server
PostgreSQL
PostgresBDR
TPC
CAP theorem
continuous synchronizatio
Opis:
Database replication is a way to improve system throughput or achieve highavailability. In most cases, the use of an active-active replica architecture isefficient and easy to deploy. Such a system has CP properties (from the CAPtheorem: consistency, availability, and network-partition tolerance). Creat-ing an AP (available and partition-tolerant) system requires the use of multi-primary replication. Because of the many difficulties in its implementation, thisapproach is not widely used; however, ALICE’s deployment of CCDB (exper-iment conditions and calibration database) needs to be an AP system in twolocations. This necessity became the inspiration for examining the state-of-the-art methods in this field and testing the available solutions. The tests thatwere performed evaluated the performance of the chosen replication tools: Bu-cardo, and EDB Replication Server; these showed that the tested tools couldbe successfully used for the continuous synchronization of two independentdatabase instances.
Źródło:
Computer Science; 2023, 24 (3); 407--426
1508-2806
2300-7036
Pojawia się w:
Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distributed web service repository
Autorzy:
Nawrocki, P.
Mamla, A.
Powiązania:
https://bibliotekanauki.pl/articles/305281.pdf
Data publikacji:
2015
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
web service
repository
heterogeneity
data replication
node balancing
Opis:
The increasing availability and popularity of computer systems has resulted in a demand for new language- and platform-independent ways of data exchange. This demand has, in turn, led to significant growth in the importance of systems based on Web services. Alongside the growing number of systems accessible via Web services came the need for specialized data repositories that could offer effective means of searching the available services. The development of mobile systems and wireless data transmission technologies has allowed us to use distributed devices and computer systems on a greater scale. The accelerating growth of distributed systems might be a good reason to consider the development of distributed Web service repositories with built-in mechanisms for data migration and synchronization.
Źródło:
Computer Science; 2015, 16 (1); 55-73
1508-2806
2300-7036
Pojawia się w:
Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA level in guard cells nuclei of Ornithogalum umbellatum ovary is 2C-4C
Autorzy:
Rogala, K
Kwiatkowska, M.
Poplonska, K.
Powiązania:
https://bibliotekanauki.pl/articles/58884.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
DNA level
guard cell
nucleus
Ornithogalum umbellatum
ovary
epidermis
DNA replication
development
Opis:
The DNA content after Feulgen reaction in the guard cells and epidermis of Omithogalum umbellatum ovary was cytophotometrically measured in different phases of flower development. Only in bud of flowers guard cells DNA content was 2C while in full blown flowers it was higher, between 2C-4C. This observation was supported by autoradiographic studies with 3H-thymidine which was incorporated into guard cell nuclei in the ovary epidermis of newly developed flowers. Thus DNA level in O. umbellatum guard cells was higher than those in other plants described in literature. On the other hand, DNA content in the epidermis cells increased gradually with ovary growth reaching the maximum level of 8C in some cells.
Źródło:
Acta Societatis Botanicorum Poloniae; 2008, 77, 3; 207-211
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA replication stress-induced biphasic nuclear structures in Allium cepa root meristem cells
Autorzy:
Zabka, A.
Polit, J.T.
Maszewski, J.
Powiązania:
https://bibliotekanauki.pl/articles/951326.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
DNA replication
cyclin-dependent kinase
cell division
biphasic nuclear structure
Allium cepa
root meristem cell
premature chromosome condensation
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficiency of Software Testing Techniques: A Controlled Experiment Replication and Network Meta-analysis
Autorzy:
Gómez, O. S.
Cortés-Verdín, K.
Pardo, C. J.
Powiązania:
https://bibliotekanauki.pl/articles/384107.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
software verification
software testing
controlled experiment
experiment replication
meta-analysis
network meta-analysis
quantitative synthesis
Opis:
Background. Common approaches to software verification include static testing techniques, such as code reading, and dynamic testing techniques, such as black-box and white-box testing. Objective. With the aim of gaining a better understanding of software testing techniques, a controlled experiment replication and the synthesis of previous experiments which examine the efficiency of code reading, black-box and white-box testing techniques were conducted. Method. The replication reported here is composed of four experiments in which instrumented programs were used. Participants randomly applied one of the techniques to one of the instrumented programs. The outcomes were synthesized with seven experiments using the method of network meta-analysis (NMA). Results. No significant differences in the efficiency of the techniques were observed. However, it was discovered the instrumented programs had a significant effect on the efficiency. The NMA results suggest that the black-box and white-box techniques behave alike; and the efficiency of code reading seems to be sensitive to other factors. Conclusion. Taking into account these findings, the Authors suggest that prior to carrying out software verification activities, software engineers should have a clear understanding of the software product to be verified; they can apply either black-box or white-box testing techniques as they yield similar defect detection rates.
Źródło:
e-Informatica Software Engineering Journal; 2017, 11, 1; 77-102
1897-7979
Pojawia się w:
e-Informatica Software Engineering Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 52

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