Temat: Extracellular matrix - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Inflammatory bowel disease: the function of metalloproteinases
Autorzy:: Pasternak, Grzegorz
Aebisher, David
Filip, Rafał
Bartusik-Aebisher, Dorota
Powiązania:: https://bibliotekanauki.pl/articles/454718.pdf
Data publikacji:: 2018
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: inflammatory bowel disease
matrix metalloproteinases extracellular matrix
Opis:: Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. Materials and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases. Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis. Conclusions. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required.
Źródło:: European Journal of Clinical and Experimental Medicine; 2018, 4; 346-349
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Artificial extracellular matrices of collagen fibrils and lactoferrin as coatings to enhance osteoblast behavior
Autorzy:: Vandorovcova, M.
Bacakova, L.
Dubruel, P.
Douglas, T. E. L.
Powiązania:: https://bibliotekanauki.pl/articles/284321.pdf
Data publikacji:: 2012
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: coating
collagen
osteoblasts
proliferation
extracellular matrix
lactoferrin
Opis:: Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.
Źródło:: Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 132-134
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Synthetic extracellular matrix as a substrate for regenerative medicine
Autorzy:: Stodolak-Zych, Ewa
Menaszek, Elżbieta
Twardy, Aleksandra
Ścisłowska-Czarnecka, Anna
Boguń, Maciej
Kolesińska, Beata
Powiązania:: https://bibliotekanauki.pl/articles/285740.pdf
Data publikacji:: 2019
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: synthetic extracellular matrix
biomimetic
peptide
polysaccharides
laboratory model
Opis:: The work presents materials characteristics of fibrous polysaccharide substrates (calcium alginate, CA) modified with short peptides. Three types of synthesized peptides (hexapeptides) were composed of: cysteine (C) and tryptophan (W) named - (WWC)2or cysteine (C) and tyrosine (Y) named (YYC)2 or phenyloalanine (F) named 6F. The peptides size distribution (DLS method) showed that they agglomerated in an alcohol medium. These results were used to select a modification method of the fibrous substrates i.e. the peptides were deposited on the fibrous alginate substrate by the electrospraying technique. Using this method three kinds of polysaccharide- peptides systems were obtained i.e.: CA/(WWC)2, CA/(YYC)2CA/6F. As a reference material, the pure calcium alginate fibrous substrate was used. The results of modification with short peptides were evaluated via scanning electron microscopy (SEM): small aggregates were observed (40-100 nm) on the surface of fibers, and the fibers size remained the same after modification (11-12 μm). The size of aggregates depended on the kind of short peptide; the smaller (40 nm) aggregates were observed when the peptide had only aromatic chain (6F), the bigger (<100 nm) ones were observed when the peptide had heterocyclic rings in the chain (WWC and YYC). All materials were contacted with osteoblast-like cells (MG-63) to test biocompatibility (cells viability after 3 and 7 days) and the results proved showed higher viability in the polysaccharide-peptide system which increased with the time of observation. The durability of polysaccharide-peptide systems was tested using the enzymatic assay: collagenase confirmed the stability of materials. The progress of degradation rate was observed using infrared spectroscopy (FTIR-ATR) - the ratio on bands with C-O and C-OH increased after degradation under in vitro conditions.Results of the investigations on the fibrous substrates have confirmed that the system is a good model of an extracellular matrix (ECM) due to its chemical composition and microstructure which both have biomimetic characteristics. Thus, it may be used as a filling of bone defects supporting the regeneration of the damaged tissue. Additionally, it may also serve as the model research system of ECM.
Źródło:: Engineering of Biomaterials; 2019, 22, 152; 10-15
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Chemical and physical modifications of electrospun fibers as a method to stimulate tissue regeneration – minireview
Autorzy:: Kurpanik, Roksana
Stodolak-Zych, Ewa
Powiązania:: https://bibliotekanauki.pl/articles/1844869.pdf
Data publikacji:: 2021
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: electrospun fibers
fibrous scaffold
surface modification
extracellular matrix
Opis:: Fibrous scaffolds based on (bio)polymers are ob¬served as mimicking the microstructure of the extracel¬lular matrix. Thus, they are considered as an example of a utilitarian scaffold, useful for the regeneration of various types of tissues. The techniques described in the literature are well known to obtain submicrometric and nanometric fibers that, when randomly arranged, mimic the ECM. The biomimetic scaffold criterion might be even better reflected if the cell adhesion sites are present on the surface of such fibers. They promote the formation of the focal adhesion contact or facilitate the formation of a protein film on the fiber surface. Such a process is enhanced by an appropriate physical or chemical modification that activates the protein adsorption and the subsequent cell adhesion. The aim of this paper is to present different methods of physical and/or chemi¬cal modifications of fibrous materials: which can serve as scaffolds to support the regeneration processes of various tissues. In terms of physical methods, only weak interactions between the surface and the modi¬fier were observed. This technique is simple but not durable. Chemisorption used as a second method of fiber modification is possible if a covalent or ionic bond is formed between the fiber and the modifier. Therefo¬re, the chemical adsorption may not be fully reversible and requires a sequence of chemical actions to form a chemical bond. The most commonly used methods are the combined methods where the first step is the physical activation of the fiber surface, which facilitates the chemical modification step.
Źródło:: Engineering of Biomaterials; 2021, 24, 159; 31-41
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Genetic Variation as a Possible Explanation for the Heterogeneity of Pain in Tendinopathy: What can we learn from other pain syndromes?
Autorzy:: Mkumbuzi, Nonhlanhla S.
Posthumus, Michael
September, Alison V.
Collins, Malcolm
Powiązania:: https://bibliotekanauki.pl/articles/1942934.pdf
Data publikacji:: 2021
Wydawca:: Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:: tendon pain
genetics
extracellular matrix genes
inflammation genes
COMT
Opis:: The mechanisms of pain in tendinopathy are unclear. Current theories implicate tendon structural changes, neovascularisation, inflammation or changes in central pain processing. As with other types of musculoskeletal pain, tendon pain has high interindividual variability and, as with other types of pain, this could be attributed to genetic variation. Notably, the association between certain genetic polymorphisms and susceptibility to tendinopathy is well established in the literature. Therefore, the investigation of the mechanisms of tendon pain should also extend to include genetic variation as a possible explanation for the clinical features of tendon pain. This review summarises the current knowledge on genetic contributors to chronic pain and highlights findings that are relevant to chronic tendon pain. In particular, based on the current hypotheses on the possible sources of tendon pain, it focuses on findings that relate to genes that encode structural connective tissue components, inflammatory markers, ion channels and catecholamines and how they may relate to chronic tendon pain. In the absence of a definitive mechanism of tendon pain, an a priori genetic approach that is guided by these current hypotheses may help elucidate the mechanisms of tendon pain which may allow a more rational approach to research and treatment.
Źródło:: Central European Journal of Sport Sciences and Medicine; 2021, 36; 57-72
2300-9705
2353-2807
Pojawia się w:: Central European Journal of Sport Sciences and Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma
Autorzy:: Młynarczyk, G.
Kudelski, J.
Darewicz, B.
Galewska, Z.
Romanowicz, L.
Powiązania:: https://bibliotekanauki.pl/articles/1918434.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Medyczny w Białymstoku
Tematy:: Extracellular matrix
matrix metalloproteinases
urinary tract tumours
renal clear cell carcinoma
Opis:: Extracellular matrix metalloproteinases - MMPs, also referred to as matrixines, provide a group of proteolytic enzymes. They belong to the family of endopeptidases that break down elements of extracellular matrix, resulting in its continuous remodelling. Their activity is regulated at multiple levels, while tissue inhibitors of metalloproteinases play a major role in this process. Metalloproteinases play a significant part in neoplastic processes due to their contribution to local tumour invasion and formation of distant metastases, as well as to angiogenesis Urinary tract tumours pose a significant diagnostic and therapeutic challenge and their incidence tends to grow every year. The aim of this part of review is to describe extracellular matrix and matrix metalloproteinases and to highlight the contribution of matrix metalloproteinases in the development of renal clear cell carcinoma.
Źródło:: Progress in Health Sciences; 2017, 7(1); 161-168
2083-1617
Pojawia się w:: Progress in Health Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: The role of serum hyaluronic acid determination in the diagnosis of liver fibrosis
Autorzy:: Gudowska, Monika
Cylwik, Bogdan
Chrostek, Lech
Powiązania:: https://bibliotekanauki.pl/articles/1038585.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: hyaluronic acid
extracellular matrix
non-invasive marker
cirrhosis
fibrosis
hepatitis
Opis:: The common pathway leading to liver fibrosis and cirrhosis is growing deposition of extracellular matrix (ECM). It results from molecular and histological rearrangement of collagens, glycoproteins and hyaluronans. Hyaluronic acid is a chief component of the extracellular matrix of connective tissues and plays the main structural role in the formation of ECM. The most important organ involved in the synthesis of hyaluronic acid is the liver. In this paper the meaning of hyaluronic acid in the diagnostics of liver diseases is discussed. Here, we focus on the described changes of hyaluronic acid concentration in the pathological processes of the liver, including alcoholic and non-alcoholic liver diseases. The results of published clinical studies have shown its high diagnostic sensitivity, which probably enables its application in laboratory diagnosis.
Źródło:: Acta Biochimica Polonica; 2017, 64, 3; 451-457
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias
Autorzy:: Antoszewska, Magdalena
Powiązania:: https://bibliotekanauki.pl/articles/1396355.pdf
Data publikacji:: 2013-05-01
Wydawca:: Index Copernicus International
Tematy:: abdominal aortic aneurysm
abdominal hernia
matrix metalloproteinases (MMP-s)
extracellular matrix (ECM)
fascia
Opis:: Abdominal aortic aneurysms and abdominal hernias become an important health problems of our times. Abdominal aortic aneurysm and its rupture is one of the most dangerous fact in vascular surgery. There are some theories pointing to a multifactoral genesis of these kinds of diseases, all of them assume the attenuation of abdominal fascia and abdominal aortic wall. The density and continuity of these structures depend on collagen and elastic fibers structure. Reducing the strengthof the fibersmaybedue to changes in the extracellular matrix (ECM) by the proteolytic enzymes-matrix metalloproteinases (MMPs) that degrade extracellular matrix proteins. These enzymes play an important role in the development of many disease: malignant tumors (colon, breast, lung, pancreas), cardiovascular disease (myocardial infarction, ischemia-reperfusion injury), connective tissue diseases (Ehler-Danlos Syndrome, Marfan’s Syndrome), complications of diabetes (retinopathy, nephropathy). One of the most important is matrix metalloproteinase-2 (MMP-2). The aim of the study was an estimation of the MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia, and in patients with only abdominal aortic aneurysm. Material and methods. The study involved 88 patients aged 42 to 89 years, including 75 men and 13 women. Patients were divided into two groups: patients with abdominal aortic aneurysm and primary abdominal hernia (45 persons, representing 51.1% of all group) and patients with only abdominal aortic aneurysm (43 persons, representing 48,9% of all group). Results. It was a statistically significant increase in MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia compared to patients with only abdominal aortic aneurysm. It was a statistically significant increase in the prevalence of POCHP in patients with only abdominal aortic aneurysm compared to patients with abdominal aortic aneurysm and primary abdominal hernia. Conclusions. Statistically significant higher MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia seems shows that this enzyme plays a role in the pathogenesis of primary abdominal hernias. The observed distribution of MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia may raise the conclusion that this enzyme determines the presence of multi-organ failure of the connective tissue - the patients with only abdominal aortic aneurysm had significantly lower MMP-2 blood levels.
Źródło:: Polish Journal of Surgery; 2013, 85, 5; 271-278
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Measuring the mechanics of morphogenesis
Autorzy:: Routier-Kierzkowska, A.-L.
Weber, A.
Kierzkowski, D.
Nakayama, N.
Mosca, G.
Huflejt, M.
Barbierde Reuille, P.
Felekis, D.
Nelson, B.
Kuhlemeier, C.
Smith, R.S.
Powiązania:: https://bibliotekanauki.pl/articles/80791.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: conference
cellular level
plant cell
osmotic potential
extracellular matrix
polysaccharide
plant morphogenesis
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Glycosaminoglycans – types, structure, functions, and the role in wound healing processes
Glikozoaminoglikany – rodzaje, struktura, funkcje i rola w procesach gojenia ran
Autorzy:: Orlińska, Kinga
Komosińska-Vassev, Katarzyna
Olczyk, Krystyna
Kowalczyk, Aleksandra
Olczyk, Paweł
Powiązania:: https://bibliotekanauki.pl/articles/18105091.pdf
Data publikacji:: 2023-11-07
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Tematy:: glycosaminoglycans
extracellular matrix
proteoglycans
wound healing
glikozoaminoglikany
macierz pozakomórkowa
proteoglikany
gojenie ran
Opis:: Glycosaminoglycans (GAGs) are a group of heteropolysaccharides, which include: chondroitin sulfates, dermatan sulfates, heparan sulfates, heparin, keratan sulfates, and hyaluronic acid. GAGs are composed of negatively charged polysaccharide chains composed of repeating disaccharide units, which include N-acetylated hexosamine residues – D-glucosamine or D-galactosamine – or N-sulfated D-glucosamine and hexuronic acid residues – D-glucuronic or L-iduronic acid – or galactose. All GAGs, except for hyaluronic acid, have a sulfate group and form proteoglycans (PGs) when attached to the core proteins. GAGs have many important biological functions influencing PGs functions. PGs are present in all types of tissues and participate in cell migration, proliferation, and differentiation. They occur mainly in the extracellular matrix (ECM), where they participate in ECM organization, structure formation and mechanical properties. They play an important role in maintaining homeostasis and also influence metabolic processes, such as bone mineralization and blood coagulation. PGs (due to the strongly negative charge of the glycan chains) are involved in the selective permeability of cell membranes. Components of the ECM, including GAGs, play a structural and functional role during the healing of tissue damage. They regulate the healing process by acting as a reservoir and modulator for cytokines and growth factors and perform structural functions by filling tissue defects during the repair process.
Glikozoaminoglikany (glycosaminoglycans – GAGs) są grupą heteropolisacharydów, w której skład wchodzą: siarczany chondroityny, siarczany dermatanu, siarczany heparanu, heparyny, siarczany keratanu oraz kwas hialuronowy. GAGs zbudowane są z ujemnie naładowanych łańcuchów polisacharydowych, złożonych z powtarzających się jednostek disacharydowych, do których należą reszty N-acetylowanej heksozoaminy – D-glukozoaminy lub D-galaktozoaminy – albo N-siarczanowanej D-glukozoaminy oraz reszty kwasu heksuronowego – D-glukuronowego lub L-iduronowego – albo galaktozy. Wszystkie GAGs, z wyjątkiem kwasu hialuronowego, posiadają grupę siarczanową oraz tworzą, po przyłączeniu do białek rdzeniowych, proteoglikany (proteoglycans – PGs). GAGs pełnią wiele ważnych biologicznych funkcji, determinujących funkcje PGs. Te ostatnie są obecne we wszystkich rodzajach tkanek, uczestniczą w procesach migracji, proliferacji i różnicowania komórek. Występują głównie w macierzy pozakomórkowej (extracellular matrix – ECM), biorąc udział w organizacji ECM, kształtując jej strukturę i właściwości mechaniczne. Pełnią istotną rolę w utrzymaniu homeostazy, a także wywierają wpływ na szereg procesów metabolicznych, takich jak mineralizacja kości i krzepnięcie krwi. PGs (ze względu na silnie ujemny ładunek łańcuchów glikanowych) biorą udział w selektywnej przepuszczalności błon komórkowych. Składniki ECM, w tym GAGs, odgrywają rolę strukturalno-czynnościową podczas gojenia się uszkodzeń tkankowych. Regulują proces gojenia poprzez stanowienie rezerwuaru i modulatora dla cytokin i czynników wzrostu oraz pełnią funkcje strukturalne poprzez wypełnianie ubytków tkankowych podczas procesu naprawczego.
Źródło:: Annales Academiae Medicae Silesiensis; 2023, 77, 1; 204-216
1734-025X
Pojawia się w:: Annales Academiae Medicae Silesiensis
Dostawca treści:: Biblioteka Nauki

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