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    Wyświetlanie 1-7 z 7
    Tytuł:
    Synthesis and biological activity of novel sulfonamides derivatives of various heterocyclic compounds
    Autorzy:
    Meena, Lakshman R.
    Sharma, Vinay S.
    Swarnkar, Pawan
    Powiązania:
    https://bibliotekanauki.pl/articles/1031472.pdf
    Data publikacji:
    2020
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    4-dichlorobenzoic acid
    Sulfonamide
    anti-fungal
    anti-malarial
    anti-microbial
    Opis:
    A novel series of Sulfonamide embedded heterocyclic derivatives were synthesized and well characterized by using 1H NMR, 13C NMR and IR spectroscopic techniques. All the new synthesized compounds were evaluated to their anti-bacterial, anti-fungal and anti- malarial activities. Noticeably, compound 5b was the most potent compound in vitro anti-microbial (S. aureus) with a MTCC value of 96 microgram/ml and compounds 5g and 5j showed most potent activity in vitro anti-fungal (C. albicans) with a MTCC value of 277microgram/ml. Similarly, compound 5e showed high potent activity of anti-malarial (P. falciparum) with mean IC50 value as compared to other synthesized derivatives.
    Źródło:
    World Scientific News; 2020, 142; 120-134
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antimicrobial resistant and virulence genes profiles of some Gram-negative bacteria from clinical isolates at Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
    Autorzy:
    Nuhu, T.
    Beng, E.O.B.
    Bolaji, R.O.
    Olayinka, T.A.
    Olayinka, B.O.
    Yahaya, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2097833.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    virulence factors
    Enterobacteriaceae
    anti-microbial resistance
    north-west Nigeria
    Opis:
    Introduction and objective. Infections due to multidrug-resistant (MDR) Enterobacteriaceae are an ongoing global threat in their management. The aim of the study was to investigate the antiimicrobial resistance (AMR) and virulence gene profiles of MDR Gram-negative isolates in Sokoto, north-west Nigeria. Materials and method. A total of 578 clinical samples were collected from patients. Suspected Gram-negative bacteria were isolated from these clinical samples: vaginal swab, pus, stool, blood, wound swab and urine, using Gram-staining and conventional biochemical reactions. These isolates were further identified with an identification kit (Microgen-GN-A), and tested against a panel of 11 antibiotics. A single polymerase chain reaction (PCR) assay targeting 13 virulence gene related to adhesion (fimH, papC, and sfaS), iron chelation (iutA, and fyuA), toxins (astA, stx1, stx2, and eaeA), biofilm (bssS), and serum resistance (traT, iss, and kapsMTII) encoding genes were evaluated. Results. A total of 276 Gram-negative isolates were identified using the Gram stain and biochemical reactions. These organisms were further confirmed with identification kit. Of the 276 isolates, 36 organisms of interest (23 Escherichia coli, 4 Klebsiella pneumoniae and 9 Proteus mirabilis) were identified. Other Gram-negative isolates accounted for the remaining 86.9%. The majority of the isolates were resistant to cefixime (100%) and partially resistant to amikacin (19.4%).The virulence genes bssS (58.3%), fimH (44.4%), and iutA (44.4%) were the most prevalent, whereas kapsMTII (5.6%) and stx2 (2.8%) were least detected, while astA was not detected in any of the isolates. Conclusion. The study elucidated the prevalence of antibiotic resistance and virulence genes in Gram-negative bacteria from clinical isolates in Sokoto, north-western Nigeria. The majority of the isolates were MDR, thereby posing a public health risk.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2020, 14, 2; 52-57
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis, spectral characterization and biological activity studies of Schiff’s base of 1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-4-amine and its metal complexes
    Autorzy:
    Jadeja, Juvansinh J.
    Gondaliya, Mitesh B.
    Mokariya, Devang M.
    Shah, Manish
    Powiązania:
    https://bibliotekanauki.pl/articles/1192661.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Schiff Bases
    anti-microbial activity
    Metal complexes
    spectral analysis
    Opis:
    N,O,O-donating tridentate ligand was prepared by condensed reaction 1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-4-amine with derivative of salicylaldehyde and its metal complexes with Zn, Cd and Hg, which is highly stable at room temperature and characterized by Mass spectra, IR, 1H and 13C NMR, ESI-MASS and TGA-DTA. Comparatively studies of anti-microbial and anti-fungal activity of different ligand and its metal complex carried out.
    Źródło:
    World Scientific News; 2016, 47, 2; 123-150
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and Characterization of N-Methyl Indole Derivatives via Desulfitative Displacement by Various Amines and Its Antimicrobial Activity
    Autorzy:
    Chodvadiya, Vijay D.
    Pambhar, Kaushik D.
    Parmar, Nilesh D.
    Dhamsaniya, Ashish P.
    Safi, Shahrukh khan A.
    Chhatbar, Pratiksha V.
    Ram, Hemal N.
    Khunt, Ranjan C.
    Patel, P. K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1065130.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Anti-microbial agents
    Desulfitative displacement
    N-methyl indole
    S-methyl
    Opis:
    A modular three step synthetic approach of N-methyl indole derivatives has been carried out by the condensation of N-methyl indole with cyanoacetic acid using acetic anhydride as solvent to yield 3-cyanoacetyl N-methyl indole, which further reacts with carbon disulphide and methyl iodide in basic condition to obtain 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis(methylthio)acrylonitrile as a scaffold. Subsequent, the scaffold when reacts with substituted various amine derivatives via desulfitative displacement forms new derivatives of 3-((substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio)acrylonitrile in moderate to good yields. All the novel compounds were evaluated for their antimicrobial activity against Gram+ve and Gram-ve bacteria and different fungal species which demonstrated well to moderate antimicrobial activity.
    Źródło:
    World Scientific News; 2019, 120, 2; 181-191
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hops as a source of biologically active compounds
    Autorzy:
    Przybyś, Marcin
    Skomra, Urszula
    Powiązania:
    https://bibliotekanauki.pl/articles/2148099.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Instytut Uprawy Nawożenia i Gleboznawstwa – Państwowy Instytut Badawczy
    Tematy:
    hop
    biological activities
    antioxidative effects
    anti-microbial effects
    anticarcinogenic effects
    Opis:
    In recent years, hop, commonly known as the plant used for the production of beer, has attracted increasing interest in the pharmaceutical and cosmetic industries. Secondary me-tabolites found in hop, such as bitter acids, polyphenols or essen-tial oils, exhibit anti-cancer, anti-inflammatory and antibacterial properties. Moreover, numerous studies confirm estrogenic activ-ity, the ability to lower blood glucose levels and sedative effects of the plant. The paper discusses secondary metabolites in hops divided into groups depending on their chemical structure. Ad-ditionally, the biological activity of the metabolites is presented herein. The prospects of using hops for purposes other than brew-ing are also demonstrated.
    Źródło:
    Polish Journal of Agronomy; 2020, 43; 83-102
    2081-2787
    Pojawia się w:
    Polish Journal of Agronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluating the Total Phenolic, Protein Contents, Antioxidant and Pharmacological Effects of Cynodon dactylon Extracts Against Escherichia coli and Staphylococcus aureus
    Autorzy:
    Ibrahim, Muhammad
    Riaz, Moazama
    Ali, Akbar
    Shaheen, Musarat
    ur Rahman, Shafiq
    Aziz, Riffat
    Alamri, Abdulhakeem S.
    Alhomrani, Majid
    Dablool, Anas S.
    Alghamdi, Saad
    Sameeh, Manal Y.
    Tashkandi, Manal A.
    Powiązania:
    https://bibliotekanauki.pl/articles/27315658.pdf
    Data publikacji:
    2023
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    Cynodon dactylon
    Anti-microbial
    Flavonoids
    Total Soluble Proteins
    Peroxidase
    Antioxidant
    Super oxide Dismutase
    Opis:
    The study was aimed to characterize the antioxidant and anti-microbial activities of Cynodon dactylon with special reference on its precise biochemical analysis. Physiological analysis that total carotenoids content (0.3884 ± 0.0172 mg/g), total chlorophyll content (6.1460 ± 0.2915 mg/g), total phenolic contents (13.4703 ± 0.1494 mg/g), chlorophyll a (3.7708 ± 0.1528 mg/g, catalase (CAT) contents (40.2844 ± 0.1515 units/ mg), total anthocyanin contents (5.0166 ± 0.2966 g–1 FW) total soluble proteins (2.9916 ± 0.1734 mg/g) and total flavonoids content (TFC) (4.7863 ± 0.0442 μg/g) was found higher in the leaves of the Cynodon dactylon whereas, chlorophyll b (2.4881 ± 0.1326 mg/g) was found higher in the stem of Cynodon dactylon, while, peroxidase (POD) contents (81.8763 ± 4.6609 units/mg) and superoxidase dismutase (SOD) activity (80.4346 ± 5.9367 units/mg) was investigated higher in roots of Cynodon dactylon. The anti-microbial activity of Cynodon dactylon extracts was performed using a good diffusion technique against two microbial strains. Among all the plant extracts, the methanolic extracts showed a maximum inhibition zone (26.87 mm) against anti-bacterial strain Escherichia coli whereas n-hexane extract showed a maximum inhibition zone (17.88 mm) against anti-fungal strain Candida albicans. This study reported the antimicrobial activity of Cynodon dactylon against some common pathogens such as Staphylococcus aureus, Escherichia coli, and Candida albicans, which are highly associated with nosocomial infection. From the given results it is concluded that Cynodon dactylon could be exploited in pharmacology due to its antioxidant and anti-microbial properties.
    Źródło:
    Polish Journal of Chemical Technology; 2023, 25, 3; 110--119
    1509-8117
    1899-4741
    Pojawia się w:
    Polish Journal of Chemical Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Novel synthesis of 3-(((E)-benzylidene)amino)-5-((Z)-3,4-dimethoxybenzylidene)-2-phenyl-3,5-dihydro-4H-imidazol-4-one derivatives as potent antimicrobial agents
    Autorzy:
    Manawar, Rohit B.
    Parmar, Mukesh B.
    Nayaka, Indresh J.
    Pandit, Brinda H.
    Shah, Manish K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1066261.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    4H-imidazol-4-one
    A. niger
    Anti-fungal
    Anti-microbial Agent
    Bioactivity
    C. albicans
    E. coli
    Elemental analysis
    IR spectroscopy
    Mass spectroscopy
    NMR spectroscopy
    P. aeruginosa
    S. aureus
    S. pyogenes
    Opis:
    Novel synthesis of 4H-imidazol-4-one derivative by reaction of (Z)-3-amino-5-(3,4 dimethoxybenzylidene)-2-phenyl-3,5-dihydro-4H-imidazol-4-one with derivative of different aromatic aldehydes and Salicyldehyde. New synthesized compound are thermally stable and neither air-nor moisture sensitive at RT. Successive library of synthesized compound characterized using IR, NMR, Elemental, Mass, and its antimicrobial activity study.
    Źródło:
    World Scientific News; 2019, 130; 42-70
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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