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    Wyświetlanie 1-3 z 3
    Tytuł:
    Robust linear predictor as EEG fluctuation analyzer in diagnosis of Alzheimers disease
    Autorzy:
    Zachová, D.
    Kukal, J.
    Vyšata, O.
    Powiązania:
    https://bibliotekanauki.pl/articles/229451.pdf
    Data publikacji:
    2011
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    Alzheimer's diseases
    EEG
    quasi-stationarity
    linear predictor
    robust identification
    Opis:
    The paper is oriented to EEG signal analysis, which is focused to quasi-stationarity hypothesis that the statistical properties of the channel signal fluctuate in time. Robust linear predictor is used for short segments of EEG as low-pass filter and the difference between the raw EEG and filter output was subject of statistical testing. Novelty is in the fluctuation measurement which enables to classify the Alzheimer's disease patients against controls.
    Źródło:
    Archives of Control Sciences; 2011, 21, 2; 121-133
    1230-2384
    Pojawia się w:
    Archives of Control Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical application of monoclonal antibodies in targeted therapy
    Autorzy:
    Superson, Maciej
    (, Katarzyna Szmyt
    Szymańska, Katarzyna
    Walczak, Kamil
    Wnorowski, Jeremi
    Zarębski, Łukasz
    Powiązania:
    https://bibliotekanauki.pl/articles/454777.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cancer
    inflammatory bowel diseases Alzheimer’s disease immunotherapy
    targeted therapy
    Opis:
    Introduction. Recently, monoclonal antibodies (mAbs) have become powerful human therapeutics in the diagnosis and treatment of many diseases. Drugs based on mAbs are approved for the treatment of cardiovascular, respiratory, hematology, autoimmunology, and oncology diseases. Aim. To present the current state of knowledge about the application of mAbs in the therapy of various diseases such as cancer, autoimmune and Alzheimer’s diseases. Material and methods. We conducted a thorough review of the scientific literature from the following databases: EBSCO, PubMed, Science Direct, and Springer Link. Results. Currently, the Food and Drug Administration (FDA) has approved more than 50 therapeutic mAbs which are applied in various clinical trials. Action of mAb are based on various mechanisms, including directly targeting the cells, modifying the host response, recognizing and degrading molecules as well as delivering cytotoxic moieties. Conclusion. Despite some limitations including side effects, and therapeutic challenges, monoclonal antibodies are an attractive option for the development of new therapies and molecular drug targets against a wide range of common diseases due to their specificity and flexibility. MAbs are considered as a great hope for medicine, and effective and safe drugs in the treatment of various diseases.y
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 338-346
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rola metali w rozwoju choroby Alzheimera i Parkinsona
    The role of metals in development Alzheimer's and Parkinson's diseases
    Autorzy:
    Żygowska, Justyna
    Szymańska, Aneta
    Powiązania:
    https://bibliotekanauki.pl/articles/2057913.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    choroba neurodegeneracyjna
    jony metali
    β-amyloid
    białka amyloidogenne
    choroba Alzheimera
    choroba Parkinsona
    neurodegenerative diseases
    amyloidogenic proteins
    amyloid β
    metal ions
    Alzheimer's disease
    Parkinson disease
    Opis:
    Neurodegenerative diseases are the consequence of progressive brain degeneration caused by the death of nerve cells. Many factors that influence the neurodegeneration development are still not fully known. A lot of studies indicate the contribution of metal ions in this process. Copper, zinc, and iron are trace elements essential for proper functioning of the body. They are part of many enzymes participating in the transmission of the nerve signals, electrons transport, neurotransmitters and nucleic acids synthesis, and oxygen storage. Disorder of metals homeostasis leads to the development of severe diseases and nervous system degenerations. An excess of copper and iron ions causes a significant increase in cellular oxidative stress. Metals catalyze the reactions of free radicals formation that destroy proteins, lipids, and nucleic acids. High concentration of copper and iron ions were found in the deposits of amyloidogenic proteins. Amyloid β (Alzheimer disease) and α synuclein (Parkinson disease) have ions binding chain structures. The metal-protein interaction increases oligomerization speed in vitro. A lot of evidence suggests that the disorder of Cu, Zn and Fe homeostasis accelerates the progress of brain neurodegeneration. Human organism contains many metals, which are not needed for the proper functioning of the body, e.g. aluminum. Al binds to nucleic acids causing an increase in cellular oxidative stress and initiating proteins oligomerization. The presence of aluminum is also considered to be disadvantageous for the nervous system. The lack of medicines for neurodegenerative diseases forces us to search for new therapies. The development of degenerations could be slowed down by chelators of toxic metals, but first, these diseases must be better understood. Adverse effects of high concentration of metal ions on brain functioning are not fully known. This knowledge is necessary to find effective drugs.
    Źródło:
    Wiadomości Chemiczne; 2022, 76, 1-2; 1-25
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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