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Wyszukujesz frazę "Ziółkowski, H." wg kryterium: Autor

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    Wyświetlanie 1-13 z 13
    Tytuł:
    Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel
    Autorzy:
    Spodniewska, A.
    Barski, D.
    Ziolkowski, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/32042.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats. Dimethoate (Group I) was administered to rats at a dose of 1/10 LD₅₀ for 5 consecutive days and pyrantel embonate (Group II) at a dose of 1/5 LD₅₀ for 3 consecutive days. The animals of group III were given both of the mentioned above compounds in the same manner as group I and II, but pyrantel embonate was applied on day 3, 4, and 5 from the beginning of dimethoate intoxication. Material from 6 rats randomly selected from each group was obtained after 3, 6 and 12 hours and 2, 7 and 14 days following the last applied dose of the compounds under study. It was found that application of pyrantel embonate caused only slight changes in the analysed parameters i.e. GSH, GPx and GR. Dimethoate administration caused disturbances in the antioxidative system manifested as a decrease in GSH concentration in the liver (max. - 37.7% after 6 hours) and an increase of GPx and GR activities in erythrocytes (max. - 21.7% and 29.6% after 3 hours, respectively), compared to the control group. The profile of changes after combined intoxication was similar, but their intensity was higher compared to the group of animals exposed to dimethoate only. Based on current studies, it was concluded that both dimethoate and pyrantel embonate at the applied doses showed a pro-oxidative activity.
    Źródło:
    Polish Journal of Veterinary Sciences; 2014, 17, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Characteristics of selected second-generation antiepileptic drugs used in dogs
    Autorzy:
    Ziolkowski, H.
    Jaroszewski, J.J.
    Ziolkowska, N.
    Jasiecka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/30162.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    second generation drug
    antiepileptic drug
    dog
    veterinary medicine
    pharmacokinetics
    Opis:
    A significant number of cases of clinical canine epilepsy remain difficult to control in spite of the applied treatment. At the same time, the range of antiepileptic drugs is increasingly wide, which allows efficient treatment. In the present paper we describe the pharmacodynamics and pharmacokinetics of the newer antiepileptic drugs which were licensed after 1990 but are still not widely used in veterinary medicine. The pharmacokinetic profiles of six of these drugs were tested on dogs. The results of experimental studies suggest that second generation antiepileptic drugs may be applied in mono- as well as in poli- treatment of canine epilepsy because of the larger safety margin and more advantageous pharmacokinetic parameters. Knowledge of the drugs’ pharmacokinetics allows its proper clinical appliance, which, in turn, gives the chance to improve the efficiency of pharmacotherapy of canine epilepsy.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 3
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Distribution of CD4plusCD8plus double positive T cells in a mouse model of allergic asthma
    Autorzy:
    Zuska-Prot, M.
    Ziolkowski, H.
    Jaroszewski, J.J.
    Maslanka, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/32502.pdf
    Data publikacji:
    2016
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The present study describes the distribution of CD4+CD8+ double-positive (DP) T cells in various immune compartments of mice with ovalbumin (OVA)-induced allergic asthma. It was found that the absolute number of DP T cells was considerably increased in the mediastinal lymph nodes and lungs of asthmatic mice as compared with that determined in the healthy subjects. On the contrary, the absolute counts of DP T cells was significantly decreased in the head and neck lymph nodes, and in peripheral blood of OVA-immunized mice. These results suggest that DP T cells may be involved in the pathogenesis of allergic asthma.
    Źródło:
    Polish Journal of Veterinary Sciences; 2016, 19, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pharmacokinetics of orally administered simvastatin in turkeys
    Autorzy:
    Jasiecka, A.
    Grabowski, T.
    Maslanka, T.
    Ziolkowski, H.
    Jaroszewski, J.J.
    Powiązania:
    https://bibliotekanauki.pl/articles/31365.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The aim of the present study was to determine the pharmacokinetics of simvastatin (SIM) administered orally in 6-week-old turkeys at a single dose of 2 mg/kg b.w. The SIM concentrations in plasma were determined by validated HPLC-MS/MS method. Mean (± SD; n = 10) values of pharmacokinetic parameters evaluated were as follows: Cmax = 0.49 ± 0.21 ng/ml, tmax = 1.6 ± 1.1 h, AUC(0-∞) = 1.08 ± 0.57 h×ng/ml, t1/2kel = 2.14 ± 1.3 h and MRT = 3.08 ± 1.52 h. The results indicate that the SIM is absorbed from the gastrointestinal tract of turkeys; however, achieved plasma level is lower compared to those observed in mammals.
    Źródło:
    Polish Journal of Veterinary Sciences; 2013, 16, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The presence of CD25 on bovine WC1 plus gamma delta T cells is positively correlated with their production of IL-10 and TGF-beta, but not IFN-gamma
    Autorzy:
    Maslanka, T.
    Jaroszewski, J.J.
    Markiewicz, W.
    Ziolkowski, H.
    Barski, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/32183.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    cattle
    WC1 cell
    T cell
    T lymphocyte
    transforming growth factor-beta
    interleukin 10
    interferon-gamma
    CD25 antigen
    CD25 molecule
    Opis:
    WC1+ cells in cattle exhibit both regulatory and effector activities. However, it has not been elucidated whether they are so plastic that both activities co-exist in one cell or there are separate subpopulations of effector and regulatory cells. Since the production of IFN-γ and IL-10 seems to be related to WC1+ cells’ effector and regulatory function, respectively, the main aim of this study was to determine whether those cytokines are produced by separate subpopulations of WC1+, or are co-produced by the same cells. Due to increasingly frequent emphasised role of consumption of IL-2 in the mechanism of suppressor action of mouse CD25+CD4+ T regulatory cells, expression of the receptor’s α chain for interleukin 2 (CD25) on WC1+ lymphocytes has been evaluated. An average of 5.21% of WC1+ cells obtained from PBMCs of 12-month-old heifers show constitutive expression of the CD25 molecule, with CD25highWC1+ and CD25lowWC1+ cells accounting for 1.05% and 4.10% of WC1+ lymphocytes, respectively. For detection of intracellular cytokine production, PBMCs were stimulated with concanavalin A. Both IFN-γ- and IL-10-producing cells within the CD25-WC1+ and CD25+WC1+ subpopulations were mainly separate subpopulations. The average percentage of IFN-γ+IL-10-, IFN-γ-IL-10+ and IFN-γ+IL-10+ cells among CD25-WC1+ lymphocytes was 4.03%, 2.67% and 0.51%, respectively. A positive correlation was observed between the presence of the CD25 molecule on WC1+ lymphocytes and production of IL-10 and TGF-β, because the average percentage of IFN-γ-IL-10+ and IFN-γ+IL-10+ among CD25+WC1+ lymphocytes was 3 and 4.5 times higher as compared to the corresponding cells in the CD25-WC1+ subpopulation, whereas the percentage of IFN-γ+IL-10- cells in both the subpopulations was not significantly different. The percentage of TGF-β+ cells within the CD25+WC1+ subpopulation was 2.72 times as high as that of CD25-WC1+ lymphocytes. Therefore, with respect to the production of IFN-γ, IL-10 and TGF-β, CD25+WC1+ lymphocytes turn out to have a more suppressor profile than CD25-WC1+.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hard water may increase the inhibitory effect of feed on the oral bioavailability of oxytetracycline in broiler chickens
    Autorzy:
    Ziółkowski, H.
    Madej-Śmiechowska, H.
    Grabowski, T.
    Jaroszewski, J.J.
    Maślanka, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087530.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    oxytetracycline
    pharmacokinetics
    broilers
    feed
    hard water
    Źródło:
    Polish Journal of Veterinary Sciences; 2019, 2; 251-258
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CD4- and CD8-expressing cells found in the bovine and porcine anterior chamber of the eye
    Autorzy:
    Ziółkowski, H.
    Maślanka, T.
    Socha, P.
    Ziółkowska, N.
    Dąbrowski, M.
    Małaczewska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087714.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    anterior chamber
    CD4+ cells
    CD8+ cells
    DP cells
    cattle
    pig
    Źródło:
    Polish Journal of Veterinary Sciences; 2018, 21, 2; 293-298
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Differences in the pharmacokinetics of flumequine after single and continuous oral administration in non-fasted broiler chickens
    Autorzy:
    Madej-Śmiechowska, H.
    Orzoł, A.
    Jasiecka-Mikołajczyk, A.
    Ziółkowski, H.
    Jaroszewski, J.J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087673.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    flumequine
    HPLC
    interactions with feed
    broiler chickens
    Źródło:
    Polish Journal of Veterinary Sciences; 2018, 21, 3; 631-634
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A comparison of the efficacy and pharmacokinetics of ivermectin after spring and autumn treatments against Cyathostominae in horses
    Autorzy:
    Sokol, R.
    Ras-Norynska, M.
    Michalczyk, M.
    Jasiecka, A.
    Ziolkowski, H.
    Jaroszewski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/30787.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The aim of the present study was to determine the efficacy of ivermectin against Cyathostominae infections and to describe the drug's pharmacokinetic parameters during two seasonal deworming treatments in horses. The study was performed on warm-blooded mares aged 3-12 years weighing 450-550 kg. A single bolus of an oral paste formulation of ivermectin was administered at a dose of 0.2 mg/kg BW in spring and autumn. Fecal samples were tested before treatment and 1, 2, 3, 4, 6, 10, 20, 30, 40, 50, 60, 75 days after treatment. Ivermectin concentrations in blood samples collected before treatment, 0.5,1, 2, 3, 4, 6, 12, 24, 36 and 48 hours after treatment, and 3, 4, 6, 8,10, 15, 20, 25, 30, 40, 50, 60 and 75 days after drug administration were determined by high pressure liquid chromatogra-phy. Drug absorption was significantly (p<0.05) slower (tmax: 21.89±11.43 h) in autumn than in spring (tmax: 9.78±8.97 h). Maximum concentrations (Cmax) of ivermectin in the blood plasma of individual horses (8.40-43.08 ng/ml) were observed 2-24 h after drug administration during the spring treatment and 2-36 h (6.43-24.86 ng/ml) after administration during the autumn treatment. Significantly higher (p<0.05) ivermectin concentrations were found during the first 4 hours after administration in spring in comparison with those determined after the autumn treatment. The administration of the recommended dose of ivermectin resulted in 100% elimination of parasitic eggs from feces in spring and autumn treatment.
    Źródło:
    Polish Journal of Veterinary Sciences; 2015, 18, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A parallel genetic algorithm for creating virtual portraits of historical figures
    Autorzy:
    Krawczyk, H.
    Proficz, J.
    Ziółkowski, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/1933983.pdf
    Data publikacji:
    2012
    Wydawca:
    Politechnika Gdańska
    Tematy:
    genetic algorithms
    fitness function
    KASKADA platform
    parallel processing
    high performance computing
    Opis:
    In this paper we present a genetic algorithm (GA) for creating hypothetical virtual portraits of historical figures and other individuals whose facial appearance is unknown. Our algorithm uses existing portraits of random people from a specific historical period and social background to evolve a set of face images potentially resembling the person whose image is to be found. We then use portraits of the person’s relatives to judge which of the evolved images are most likely to resemble his/her actual appearance. Unlike typical GAs, our algorithm uses a new supervised form of fitness function which itself is affected by the evolution process. Additional description of requested facial features can be provided to further influence the final solution (i.e. the virtual portrait). We present an example of a virtual portrait created by our algorithm. Finally, the performance of a parallel implementation developed for the KASKADA platform is presented and evaluated.
    Źródło:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2012, 16, 1-2; 145-162
    1428-6394
    Pojawia się w:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lorentz force eddy current testing : two-dimensional numerical study
    Testowanie wiroprądowe w oparciu o pomiar siły Lorentza : dwuwymiarowe studium numeryczne
    Autorzy:
    Zec, M.
    Uhlig, R.P.
    Ziolkowski, M.
    Brauer, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/159012.pdf
    Data publikacji:
    2011
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Elektrotechniki
    Tematy:
    siła Lorentza
    magnes trwały
    prądy wirowe
    wady
    testowanie wiroprądowe
    permanent magnet
    eddy currents
    Lorentz force
    defects
    defect detection
    contactless testing
    non-destructive testing
    Opis:
    The main aim of this work is to provide 2D numerical data for the motion of a permanent magnet in the vicinity of a solid state body. The goals of this work include the evaluation of induced eddy current, total and current Lorentz Force (LF) distribution insi de a solid body accounting for pre-defined defects. The approach of logi cal expressions and of a moving mesh were used successfully to solve the presented linear eddy current testing problem (LET). The logi cal expression approach, for the similar number of degrees of freedom, was able to solve the given problem approximately 8 times faster than the moving mesh approach.
    Testowanie z wykorzystaniem prądów wirowych i pomiarów siły Lorentza jest bezstykową i nieniszczącą metodą służącą do detekcji głębokich defektów w materiałach stałych przewodzących. Zasada tej metody jest oparta na pomiarze siły Lorentza wytwarzanej w wyniku wzajemnego ruchu między magnesem trwałym i badanym materiałem. Gdy magnes jest przesuwany ponad defektem, to siła Lorentza działająca na magnes ulega chwilowym zmianom. Detekcja tych perturbacji siły Lorentza pozwala identyfikować i lokalizować defekty w materiale. Głównym celem niniejszej pracy jest dostarczenie dwuwymiarowych danych numerycznych dla ruchu magnesu trwałego w sąsiedztwie ciała stałostanowego. Analiza jest przeprowadzona dla tzw. liniowego problemu testowania wiroprądowego, biorącego pod uwagę liniowy ruch magnesu trwałego nad prętem w stanie stałym. Metodę elementów skończonych opartą na handlowym solwerze COMSOL Multiphysics użyto do symulowania rzeczywistej geometrii danego problemu z odpowiednimi równaniami różniczkowymi. Cele tej pracy obejmują ocenę indukowanych prądów wirowych, rozkład ogólnych i lokalnych sił Lorentza.
    Źródło:
    Prace Instytutu Elektrotechniki; 2011, 252; 55-66
    0032-6216
    Pojawia się w:
    Prace Instytutu Elektrotechniki
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lorentz force eddy current testing: validation of numerical results
    Testowanie wiroprądowe w oparciu o pomiar siły Lorentza
    Autorzy:
    Uhlig, R.P.
    Zec, M.
    Ziolkowski, M.
    Brauer, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/159341.pdf
    Data publikacji:
    2011
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Elektrotechniki
    Tematy:
    stan stały
    pomiar nieniszczący
    wady
    model analityczny
    model numeryczny
    symulacja
    metoda elementów skończonych
    solid state specimens
    non-destructive measurement
    defects
    analytical models
    numerical models
    simulation
    finite element method
    Opis:
    The paper at hand reports investigations regarding the characterization of an a electrically conducting solid state specimen with a new non-destructive measurement technique for the detection of subsurface defects. On the one hand it is necessary to characterize a specimen without defects in order to detect defects, on the other hand we show the validation of the analytical and numerical models that are used to simulate the application.
    Artykuł opisuje badania charakteryzujące elektrycznie przewodzącą próbkę w stanie stałym przy użyciu nowej nieniszczącej techniki pomiarowej w celu detekcji defektów podpowierzchniowych
    Źródło:
    Prace Instytutu Elektrotechniki; 2011, 251; 135-145
    0032-6216
    Pojawia się w:
    Prace Instytutu Elektrotechniki
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sedimentary petrology characteristics and their implications for provenance of Hoanh Bo Basin Neogene system in Quang Ninh province, north-eastern Vietnam
    Autorzy:
    Tha, H.V.
    Wysocka, A.
    Cuong, N. Q.
    Pha, P.D.
    Ziółkowski, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/184381.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    conglomerate
    sandstone
    petrography
    Hoanh Bo Basin
    Neogene
    Vietnam
    Opis:
    The Hoanh Bo Basin has developed over multiple periods since the Miocene period in association with the tectonic activity of the Chi Linh-Hon Gai and Trung Luong Faults. The basin is filled with Neogene continental sediments, comprising mainly polymictic conglomerates, sandstones, siltstones, claystones, and shales. Coarser-grained polymictic deposits predominate along the northern and western margins of the basin, whereas different types of siltstones, claystones, and sandstones occur in its centre, as well as along its southern and eastern parts, toward the Ha Long Bay. The conglomerates and sandstones are composed mainly of quartz and sedimentary rock fragments, and a small amount of mica. Cement is mainly built of iron-oxide, clay or carbonate mud. The source area for the Hoanh Bo Basin sediments was located in the close vicinity of the basin. It was built of strongly weathered rocks of the Hon Gai, Ha Coi, Cat Ba Formations.
    Źródło:
    Geology, Geophysics and Environment; 2017, 43, 1; 69-87
    2299-8004
    2353-0790
    Pojawia się w:
    Geology, Geophysics and Environment
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-13 z 13

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