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Tytuł:
The role of probiotic intervention in regulating gut microbiota, short-chain fatty acids and depression-like behavior in lead-exposed rats
Autorzy:
Chen, Xiaojun
Meng, Shujuan
Yu, Yongli
Li, Shuang
Wu, Lei
Zhang, Yanshu
Powiązania:
https://bibliotekanauki.pl/articles/2085714.pdf
Data publikacji:
2022-02-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
depression
lead exposure
probiotic
gut microbiota
SCFAs
neurobehavioral tests
Opis:
ObjectivesThe aim of this study was to observe the depression-like behavior changes of rats exposed to lead with or without probiotic intervention, and to investigate changes in the gut microbiota and fecal short-chain fatty acids (SCFAs) levels after lead exposure, and the possible functions of probiotics in this process.Material and MethodsAdult male Sprague Dawley rats were exposed to a 300 mg/l lead acetate solution for 24 weeks, with or without probiotic (freeze-dried powder containing Lactobacillus and Bifidobacterium: 6 billion live bacteria/2 g) intervention in weeks 17–24. The sucrose preference test (SPT), the forced swim test (FST), and the tail suspension test (TST) were preformed to study the depression-like behaviors of these rats. The alteration of rat gut microbiota induced by lead exposure was analyzed by 16S rRNA sequencing, and the levels of fecal SCFAs were detected using gas chromatography.ResultsNeurobehavioral tests showed that lead exposure induced depression-like behavior in rats, including reduced sucrose preference in the SPT, and increased immobility times in the FST and the TST. Sequencing and gas chromatography showed that lead exposure changed the structure and the phylogenetic diversity of the gut microbiota, as well as significantly altered the levels of SCFAs. Moreover, the depression-like behaviors, and the changes in both gut microbiota and SCFAs, could be mitigated by probiotic intervention.ConclusionsLead exposure not only changes the structure and diversity of the gut microbiome but also affects metabolic function. Probiotic intervention may be a novel initiative for the prevention and treatment of neurological damage following lead exposure. Health. 2022;35(1):95–106
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 1; 95-106
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on safe disposal of cephalosporins based on kinetic pyrolysis mechanism
Autorzy:
Fan, Jiangxue
Zhang, Meng
Hou, Xiaofei
Wang, Fang
Bai, Mengyuan
Jiao, Ruoxi
Yang, Zhongyu
Duan, Erhong
Cheng, Fengfei
Zhou, Wen
Powiązania:
https://bibliotekanauki.pl/articles/27315672.pdf
Data publikacji:
2023
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Distillation residues
Thermal analysis kinetics
Template “3-2-2”
Template “1+1”
Pyrolysis mechanism
Opis:
Based on the global goals for cleaner production and sustainable development, the pyrolysis behavior of cephalosporin residues was studied by TG-MS method. The influence of full temperature window on the safe disposal of residues was analyzed based on the “3-2-2” and “1+1” of thermal analysis kinetics, and the gas by-products of thermal degradation were monitored. Results showed that the pyrolysis of distillation residues were divided into low and high-temperature zones, including six stages. Maximum error rate (8.55%) by multiple scan rate was presented based on “3-2-2” pattern and maximum total fluctuation (33.7) by single scan rate was presented based on “1+1” pattern, which implied that the comprehensive multi-level comparison method was very reliable. The E value “E” of six stages showed an increasing trend ranging 166.8 to 872.8 kJ/mol. LgA(mean) was 27.28. Most mechanism function of stage 1, 2 were Z-L-T equation (3D), stage 3, 4, 6 were Avrami-Erofeev equation (AE3, AE4, AE2/3) and stage 5 was Reaction Order (O2). In addition, various small molecular micromolecule substances were detected such as C2H4O, C2H6, NH3, CH4, CO2 under full temperature windows and a possible pyrolysis path of residues was provided.
Źródło:
Polish Journal of Chemical Technology; 2023, 25, 4; 52--60
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on characteristics of three-dimensional granular meso-reconstruction of coal gangue roadbed
Autorzy:
Fan, Xiang-Xi
Hui, Bing
Ma, Shi-Jie
Fu, Jian-Cun
Zhang, Wen-Jun
Meng, Ling-Xiao
Sun, Zhi
Powiązania:
https://bibliotekanauki.pl/articles/2086979.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
coal gangue roadbed
particle flow
mesoscopic reconstruction
particle breakage
Opis:
The dynamic evolution process of the coal gangue particles’ core retention phenomenon in the process of crushing under stress, the evolution law of grading and the corresponding microscopic mechanical characteristics after continuous particle crushing are analyzed. The meso-level which reveals deformation phenomena of granular materials under the action of external loads is highly complex. At the qualitative level, the static compaction process of coal gangue samples can be roughly divided into three stages: initial compaction stage, compaction and crushing stage, and crushing (compaction) stage. It is proved that the interaction of lateral confined unidirectional compression of granular materials is mainly compression.
Źródło:
Journal of Theoretical and Applied Mechanics; 2022, 60, 3; 361--374
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Calculation of salt basin depth using fluid inclusions in halite from the Ordovician Ordos Basin in China
Autorzy:
Galamay, Аnatolіy R.
Meng, Fanwei
Bukowski, Krzysztof
Lyubchak, Aleksandr
Zhang, Yongsheng
Ni, Pei
Powiązania:
https://bibliotekanauki.pl/articles/2058592.pdf
Data publikacji:
2019
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
halite
gas-liquid inclusion
brine depth
Ordos Basin
Ordovician evaporate
Opis:
During the Middle Ordovician, the salt deposits of the Majiagou Formation of the Ordos Basin in North China formed, the halite including various genetic types of fluid inclusion. In this study, fit-testing of primary inclusions was performed to reconstruct the physical and chemical conditions during original halite sedimentation. During the post-sedimentation stage, salt was subjected to elevated temperatures (62-70°C) and pressures of tens of megapascals. From these measurements and mathematical calculations, the gas pressure was identified in the primary fluid inclusions, which allowed us to estimate that the brine column thickness in the salt basin was approximately 40 m.
Źródło:
Geological Quarterly; 2019, 63, 3; 619--628
1641-7291
Pojawia się w:
Geological Quarterly
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fast attack detection method for imbalanced data in industrial cyber-physical systems
Autorzy:
Huang, Meng
Li, Tao
Li, Beibei
Zhang, Nian
Huang, Hanyuan
Powiązania:
https://bibliotekanauki.pl/articles/23944834.pdf
Data publikacji:
2023
Wydawca:
Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:
intrusion detection system
industrial cyber-physical Systems
imbalanced data
all k-nearest neighbor
LightGBM
Opis:
Integrating industrial cyber-physical systems (ICPSs) with modern information technologies (5G, artificial intelligence, and big data analytics) has led to the development of industrial intelligence. Still, it has increased the vulnerability of such systems regarding cybersecurity. Traditional network intrusion detection methods for ICPSs are limited in identifying minority attack categories and suffer from high time complexity. To address these issues, this paper proposes a network intrusion detection scheme, which includes an information-theoretic hybrid feature selection method to reduce data dimensionality and the ALLKNN-LightGBM intrusion detection framework. Experimental results on three industrial datasets demonstrate that the proposed method outperforms four mainstream machine learning methods and other advanced intrusion detection techniques regarding accuracy, F-score, and run time complexity.
Źródło:
Journal of Artificial Intelligence and Soft Computing Research; 2023, 13, 4; 229--245
2083-2567
2449-6499
Pojawia się w:
Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A self-scheduling strategy of virtual power plant with electric vehicles considering margin indexes
Autorzy:
Jiao, Fengshun
Deng, Yongsheng
Li, Duo
Wei, Bo
Yue, Chengyan
Cheng, Meng
Zhang, Yapeng
Zhang, Jiarui
Powiązania:
https://bibliotekanauki.pl/articles/949880.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
electric vehicle (EV)
response time margin (RTM)
scheduling strategy
state of charge margin (SOCM)
virtual power plant (VPP)
Opis:
From the perspective of a virtual power plant (VPP) with electric vehicles (EVs), a self-scheduling strategy considering the response time margin (RTM) and state of charge margin (SOCM) is proposed. Firstly, considering the response state of the state of charge (SOC) and charge-discharge state of EVs, a VPP based response capacity determination model of EVs is established. Then, RTM and SOCM indexes are introduced on the basis of the power system scheduling target and the EV users’ traveling demands. The RTM and SOCM indices are calculated and then are used to generate a priority sequence of responsive EVs for the VPP. In the process of the scheduling period and rolling iteration, the scheduling schemes of the EVs in the VPP for multiple time periods are determined. Finally, the VPP self-scheduling strategy is validated by taking an VPP containing three kinds of EV users as an example. Simulation results show that with the proposed strategy, the VPP is able to respond to the scheduling power from the power system, while ensuring the traveling demands of the EV users at the same time.
Źródło:
Archives of Electrical Engineering; 2020, 69, 4; 907-920
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Remaining useful life prediction of cylinder liner based on nonlinear degradation model
Autorzy:
Kang, Jianxiong
Lu, Yanjun
Zhao, Bin
Luo, Hongbo
Meng, Jiacheng
Zhang, Yongfang
Powiązania:
https://bibliotekanauki.pl/articles/2057982.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
remaining useful life
cylinder liner wear
nonlinear degradation
maximum likelihood estimation
adaptive PDF
Opis:
In order to effectively monitor the wear and predict the life of cylinder liner, a nonlinear degradation model with multi-source uncertainty based on Wiener process is established to evaluate the remaining useful life (RUL) of cylinder liner wear. Due to complex service performance of cylinder liner, the uncertainty of operational environment and working conditions of cylinder liner wear are considered into the model by a random function. The probability density function (PDF) formula of RUL is derived, and the maximum likelihood estimation method is adopted to estimate the unknown parameters of PDF. Considering the evaluated parameters as the initial values, the model parameters are updated adaptively, and an adaptive PDF is obtained. Furthermore, the proposed model is compared with two classical degradation models. The results show that the proposed model has a good performance for predicting the life, and the error is within 5%. The method can provide a reference for condition monitoring of cylinder liner wear.
Źródło:
Eksploatacja i Niezawodność; 2022, 24, 1; 62--69
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dual-parameter sensing characteristics of a single fiber Bragg grating half-pasted by 1C-LV epoxy under different curing
Autorzy:
Li, Hong
Zhang, Haoyue
Song, Yanming
Meng, Fanyong
Zhu, Lianqing
Powiązania:
https://bibliotekanauki.pl/articles/2033955.pdf
Data publikacji:
2021
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
fiber Bragg grating
cross-sensitivity
double peaks
surface pasting
curing
Opis:
A novel technology for the simultaneous and independent measurement of dual parameters is proposed and experimented. By using a single fiber Bragg grating half-pasted by 1C-LV epoxy under different curing conditions, the sensor structure is designed such that the reflective single-peak spectrum splits into a twin-peak spectrum, which makes the FBG spectrum form a natural spectral peak splitting bias. A measurement limitation exists in the FBG sensor packaging at room temperature, which can be solved by the high-temperature cured packaging method. To verify the validity of the theory and methodology, the experimental system is used. In the range from –1000 to +1000 με and from 35 to 75°C, the Bragg wavelength change is relative linear to the strain and temperature. The temperature and strain variations can be independently and simultaneously measured using the split peak, and the deviations of the FBG sensor are ±1°C and ±5 με, respectively. This single FBG sensor can realize dual-parameter measurement, which is valuable for narrow-space health monitoring.
Źródło:
Optica Applicata; 2021, 51, 3; 391-406
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Friction Between Footwear and Floor Covered With Solid Particles Under Dry and Wet Conditions
Autorzy:
Li, K. W.
Meng, F.
Zhang, W.
Powiązania:
https://bibliotekanauki.pl/articles/90294.pdf
Data publikacji:
2014
Wydawca:
Centralny Instytut Ochrony Pracy
Tematy:
slip & fall
friction measurement
solid contaminants
Brungraber Mark II
upadek
tarcie
podłoga
obuwie
Opis:
Solid particles on the floor, both dry and wet, are common but their effects on the friction on the floor were seldom discussed in the literature. In this study, friction measurements were conducted to test the effects of particle size of solid contaminants on the friction coefficient on the floor under footwear, floor, and surface conditions. The results supported the hypothesis that particle size of solids affected the friction coefficient and the effects depended on footwear, floor, and surface conditions. On dry surfaces, solid particles resulted in friction loss when the Neolite footwear pad was used. On the other hand, solid particles provided additional friction when measured with the ethylene vinyl acetate (EVA) footwear pad. On wet surfaces, introducing solid particles made the floors more slip-resistant and such effects depended on particle size. This study provides information for better understanding of the mechanism of slipping when solid contaminants are present.
Źródło:
International Journal of Occupational Safety and Ergonomics; 2014, 20, 1; 43-53
1080-3548
Pojawia się w:
International Journal of Occupational Safety and Ergonomics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Extraction, Chemical Composition and Antidiabetic Potential of Crude Polysaccharides from Centella asiatica (L.) Urban
Autorzy:
Li, Meng
Shahid, Muhammad
Zhang, Xiaobin
Law, Douglas
Mackeen, Mukram M.
Teh, Arnida H.
Najm, Ahmad A.
Fazry, Shazrul
Othman, Babul A.
Powiązania:
https://bibliotekanauki.pl/articles/31341117.pdf
Data publikacji:
2024-05-24
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
alcohol insoluble residue
antidiabetic
mineral elements
monosaccharide composition
response surface methodology
Opis:
The global prevalence of diabetes mellitus (DM) is escalating, posing a significant challenge to human healthcare systems. In the present study, mineral and monosaccharide compositions, and antidiabetic potential of polysaccharide fractions separated from Centella asiatica (L.) leaves (CAL) were assessed. Initial single-factor experiments identified key extraction parameters, further optimized through response surface methodology (RSM) with optimal conditions determined as a liquid-to-solid ratio of 24.43:1 (mL/g), extraction time of 60.76 min, and a temperature of 83.31℃. Alcohol insoluble residue (AIR) extraction yielded three crude polysaccharide fractions (P50, P70, and P90). P50 was obtained with the highest yield (14.31%) and exhibited the highest content of total sugars and uronic acids (68.01 and 24.28 g/100 g, respectively). Calcium, magnesium, and manganese were dominant minerals in P50 and P70. Monosaccharide composition analysis via high-performance liquid chromatography (HPLC) demonstrated enrichment of galacturonic acid, galactose, and arabinose in P50 and P70. Furthermore, both fractions (P50 and P70) exhibited dose-dependent inhibitory effects on α-amylase and α-glucosidase. At 5 mg/mL, P50 caused 68.3% α-amylase inhibition and 62.3% α-glucosidase inhibition, while P70 triggered 46.8% and 34.1% inhibition, respectively. In conclusion, this study is the first to provide valuable insights into optimizing CAL extraction conditions. Potential utilization of polysaccharide fractions obtained from CAL as components for formulating functional foods can be explored in the future.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2024, 74, 2; 177-187
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A BIM technology-based underwater structure damage identification and management method
Autorzy:
Li, Xiaofei
Su, Rongrong
Cheng, Peng
Sun, Heming
Meng, Qinghang
Song, Taiyi
Wei, Mengpu
Zhang, Chen
Powiązania:
https://bibliotekanauki.pl/articles/2204531.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
building information modeling
underwater structural disease
damage identification
deep learning
modelowanie informacji o budynku
identyfikacja uszkodzeń
uczenie głębokie
uszkodzenie podwodnej konstrukcji
Opis:
With the continuous development of bridge technology, the condition assessment of large bridges has gradually attracted attention. Structural Health Monitoring (SHM) technology provides valuable information about a structure's existing health, keeping it safe and uninterrupted use under various operating conditions by mitigating risks and hazards on time. At the same time, the problem of bridge underwater structure disease is becoming more obvious, affecting the safe operation of the bridge structure. It is necessary to test the bridge’s underwater structure. This paper develops a bridge underwater structure health monitoring system by combining building information modeling (BIM) and an underwater structure damage algorithm. This paper is verified by multiple image recognition networks, and compared with the advantages of different networks, the YOLOV4 network is used as the main body to improve, and a lightweight convolutional neural network (Lite-yolov4) is built. At the same time, the accuracy of disease identification and the performance of each network are tested in various experimental environments, and the reliability of the underwater structure detection link is verified.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2023, 71, 2; art. no. e144602
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tests and analyses on mechanical characteristics of dwarf-dense-early major cotton variety stalks
Autorzy:
Liang, R.
Chen, X.
Zhang, B.
Peng, X.
Meng, H.
Jiang, P.
Li, J.
Zhou, P.
Kan, Z.
Powiązania:
https://bibliotekanauki.pl/articles/2082915.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Instytut Agrofizyki PAN
Tematy:
cotton stalk
dwarf-dense-early
multiple factors
mechanical characteristics
Opis:
The influence of the variation in water content, sampling location and loading speed on the shearing and across-compression mechanical characteristics of dwarf-denseearly major cotton variety stalks was analysed. The second-order response models of the factors vs. the maximum shear force and critical across-compression failure force were built using the response surface methodology. Besides, the sampling location and water content have a significant influence over the maximum shear force and critical across-compression failure force, especially the sampling location. Both the maximum shear force and critical across-compression failure force reach a theoretical maximum when the water content is 10%, the sampling location is the lower part and the loading speed is 40 mm min-1. When the sampling location is the lower part, optimization is carried out assuming the theoretical minimum of the maximum shear force and critical across-compression failure force as the optimization target. In this case, the loading speed is 20 mm min-1, while the water content is between 30 and 50%. This indicates that the parameter range requires a low power consumption during the crushing of film residue mixtures. The test data can provide some theoretical references for the technical research and equipment development for the crushing of film.
Źródło:
International Agrophysics; 2020, 34, 3; 333-342
0236-8722
Pojawia się w:
International Agrophysics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A genetic algorithm-based approach for flexible job shop rescheduling problem with machine failure interference
Autorzy:
Liang, Zhongyuan
Zhong, Peisi
Zhang, Chao
Yang, Wenlei
Xiong, Wei
Yang, Shihao
Meng, Jing
Powiązania:
https://bibliotekanauki.pl/articles/27320976.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
genetic algorithm
rescheduling
machine failure
flexible job shop scheduling
Opis:
Rescheduling is the guarantee to maintain the reliable operation of production system process. In production system, the original scheduling scheme cannot be carried out when machine breaks down. It is necessary to transfer the production tasks in the failure cycle and replan the production path to ensure that the production tasks are completed on time and maintain the stability of production system. To address this issue, in this paper, we studied the event-driven rescheduling policy in dynamic environment, and established the usage rules of right-shift rescheduling and complete rescheduling based on the type of interference events. And then, we proposed the rescheduling decision method based on genetic algorithm for solving flexible job shop scheduling problem with machine fault interference. In addition, we extended the "mk" series of instances by introducing the machine fault interference information. The solution data show that the complete rescheduling method can respond effectively to the rescheduling of flexible job shop scheduling problem with machine failure interference.
Źródło:
Eksploatacja i Niezawodność; 2023, 25, 4; art. no. 171784
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Static and dynamic test analysis of a 12-years old 14 000-ton cable-stayed bridge used swivel construction technology
Autorzy:
Liu, Meng
Sun, Quansheng
Yu, Haitao
Yang, Jianxi
Zhang, Tongzhou
Powiązania:
https://bibliotekanauki.pl/articles/2036414.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
In order to study the change in performance of the Suifenhe cable-stayed bridge in China over 12 years, cable force, elevation, static and dynamic load tests were conducted in 2006 and 2018, respectively. In this paper, theoretical data, obtained through finite element model analysis, were compared with the measured load test data for changes in static and dynamic performances. A comparison between 2006 and 2018 shows that additional dead load deflection exists in the main span after 12 years of operation. And that the cable force due to dead load of the full-scale cable-stayed bridge decreases and redistributes, which have adverse effects on the safety of bridge structure after long-term operations. Therefore, on-site inspection, static and dynamic load tests are reco mmended for cable-stayed bridges over 10-years old to test their static and dynamic performance. Moreover, cable force adjustments are to be conducted whenever necessary for the cable-stayed bridge used swivel construction.
Źródło:
Archives of Civil Engineering; 2021, 67, 4; 369-381
1230-2945
Pojawia się w:
Archives of Civil Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway
Autorzy:
Lu, Qian
Hao, Meng
Wu, Wenya
Zhang, Nan
Isaac, Adelusi
Yin, Jiale
Zhu, Xia
Du, Lei
Yin, Xiaoxing
Powiązania:
https://bibliotekanauki.pl/articles/1038521.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Ginkgo biloba extract
rutin
quercetin
diabetic cataract
Opis:
One of the earliest critical secondary complications of diabetes is the opacification of the eye lens - a condition strictly associated with diabetic cataract. The study presented here was designed to investigate the effect of Ginkgo biloba extract (GbE), rutin and quercetin on streptozotocin (STZ) induced diabetic cataract (DC) rats. Ten weeks after administration of GbE, rutin and quercetin, the opacity of diabetic rats' lenses was graded under a slit lamp. Then, the levels of malondialdehyde (MDA), reduced glutathione (GSH), advanced glycosylation end products (AGEs), and the activities of aldose reductase (AR) were estimated. The DC-induced rats produced less GSH, higher levels of MDA and AGEs as well as elevated AR activity when compared to the normal group. Administration of GbE, rutin and quercetin remarkably inhibited the AR activity, stimulated the production of glutathione, and decreased the levels of MDA and AGEs in the lenses of DC-induced rats, which eventually delayed the progression of lens opacification in diabetic rats to various degrees. Our results revealed that quercetin had the highest significant (P<0.05) potential to delay the progression of STZ-induced diabetic cataract when compared with rutin and GbE. The mechanism dictating this interesting prowess of quercetin might be attributed to its AR inhibitory strength, anti-lipid peroxidation potential and anti-AGEs activity.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 35-41
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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