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Tytuł:
Lipidomic profiles as a tool to search for new biomarkers
Autorzy:
Pisarska, Anna
Wąsowicz, Wojciech
Gromadzińska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2084885.pdf
Data publikacji:
2022-04-11
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
cancer
biomarkers
lipids
lipidomics
kidney disease
metabolomic disease
Opis:
Lipidomics belongs to the family of the so-called omics domains, which, based on modern chemical technologies, strive to explain the biological principles of the organism’s functioning. Main biological functions of lipids include energy storage, the formation of cell membranes, and participation in the transmission of biological signals, and their dysregulation is responsible for the development of pathological states. Thanks to lipid profiling, potential biomarkers for disease diagnosis and prognosis can be identified. This paper discusses selected examples of the use of lipidomic tests in the diagnosis of the kidney, metabolic and neoplastic diseases based on research papers published over the last few years (since 2016). Only works based on the study of human biological material by mass spectrometry methods were taken into account. The examples of lipidomics application presented in this publication are only a few of the possibilities of this technique. As potential possibilities have already been discovered, the next step for the research community is to work on standardization of the approach to lipidomic research and to develop bioinformatics methods that allow efficient processing and analysis of large amounts of data generated in this technique.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 2; 111-126
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metabolism and in vitro assessment of the mutagenic activity of urinary extracts from rats after inhalation exposure to 1-methylnaphthalene
Autorzy:
Świercz, Radosław
Stępnik, Maciej
Gromadzińska, Jolanta
Domeradzka-Gajda, Katarzyna
Roszak, Joanna
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2152982.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
rats
inhalation
micronucleus test
toxicokinetics
1-methylonaphthalene
1-naphthoic acid
Opis:
Objectives 1-Methylnaphthalene (1-MN) is composed of 2 benzene rings and belongs to polycyclic aromatic hydrocarbons. The metabolism of 1-MN in laboratory animals and bacteria leads to the formation of 1-naphthoic acid (1-NA). Material and Methods In this study the distribution of 1-NA in lung, liver, spleen, kidney and urinary excretion of 1-NA in rats after single and repeated inhalation exposure to 1-MN vapors were investigated. The activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and cytochrome were measured of the rats. Genotoxic effects were evaluated with the in vitro micronucleus test on V79 hamster fibroblasts. Results The concentrations of 1-NA in the tissues of rats after single and repeated exposure to 1-MN were dependent on the exposure dose. High levels of 1-NA were found in kidneys of animals after the single and repeated exposure to 1-MN. With an increase of 1-MN dose, an increase in the activity of cytochrome P450 (CYP1A1 and CYP1A2) was observed in the liver of rats. Compared to control animals, significantly higher ALT activity was noted in serum of rats exposed to 1-MN. The micronuclei frequency in V79 cells exposed to 1-MN (in the range of analyzable concentrations; i.e., 5–25 μg/ml) did not differ significantly from the vehicle control, whereas urine extracts from rats exposed to 1-MN induced a significant increase in the frequency of micronuclei compared to urine extracts from the group of control animals. Conclusions Metabolism of 1-MN in rats after the inhalation exposure leading to 1-NA was mainly observed during the first day after the end of exposure. It is likely that 1-MN metabolites present in rat urine can induce the increased micronuclei frequency as was shown in V79 cells.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 6; 731-746
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Can the effects of chromium compounds exposure be modulated by vitamins and microelements?
Autorzy:
Sijko, Monika
Janasik, Beata
Wąsowicz, Wojciech
Kozłowska, Lucyna
Powiązania:
https://bibliotekanauki.pl/articles/2086573.pdf
Data publikacji:
2021-08-05
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
zinc
folic acid
selenium
hexavalent chromium
vitamin E
vitamin C
Opis:
Chromium (Cr) is a very common element. It occurs in 2 oxidation states, Cr(III) and Cr(VI). Although Cr(III) is not considered an element essential for mammals, it raises lots of controversy due to its role in the body. While Cr(III) action should be considered an effect of pharmacological action, Cr(VI) is included in the first group of carcinogens for humans. Moreover, it induces numerous pathological changes in the respiratory, urinary, reproductive and digestive systems. In addition, Cr(VI) is used in many industry branches, causing millions of workers all over the world to be exposed to Cr(VI) compounds. A considerable number of the occupationally exposed individuals are in favor of a deep analysis of the mechanisms of Cr(VI) action and a search for a way to reduce its negative impact on the human body. Numerous reactive oxygen species inducing oxidative stress and causing various damage are produced during Cr(VI) reduction in the cells. A good balance between antioxidants and pro-oxidants can reduce Cr(VI)-induced damage. The influence of vitamins and microelements on the adverse Cr(VI) effects has no systematic research results summary. Therefore, this work focuses on the role of dietary antioxidants such as vitamins and microelements in the prevention of Cr(VI) adverse health effects. Numerous studies have revealed a protective influence of vitamins (mainly vitamins E and C) as well as microelements (especially selenium) on the reduction of Cr(VI)-induced adverse changes. A potential protective effect of these ingredients may be useful in occupational groups that are particularly exposed to Cr(VI). However, more research in this area is required.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2021, 34, 4; 461-490
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health risk in road transport workers. Part I. Occupational exposure to chemicals, biomarkers of effect
Autorzy:
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2161975.pdf
Data publikacji:
2019-06-14
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
drivers
occupational exposure
markers of occupational exposure
inflammation
Oxidative stress
chemicals
Opis:
Motor vehicle emissions constitute a mixture of different chemicals: volatile organic solvents, polycyclic aromatic hydrocarbons, heavy metals, isocyanates, etc. Drivers working in car cabins are exposed to chemicals deriving from incomplete combustion of fuels, exhaust emissions from working engines and fuel evaporation. Concentrations of these substances are rather low and do not exceed the applicable hygiene standards, but some of them pose, or are suspected to pose, carcinogenic risk. The interaction of chemical substances with human cells and tissues can lead to a number of modifications of metabolic pathways at a cellular level. The first biological mechanism of metabolic modulation is an inflammatory state and oxidative stress generation. The aim of this review is to analyze biomarkers of effect and to assess the hazard of occupational exposure of drivers. Int J Occup Med Environ Health. 2019;32(3):267–80
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2019, 32, 3; 267-280
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health risk in transport workers. Part II. Dietary compounds as modulators of occupational exposure to chemicals
Autorzy:
Kozłowska, Lucyna
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2161959.pdf
Data publikacji:
2019-07-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
diet
heavy metals
benzene
dietary supplements
transport workers
Benzo(a)pyrene
Opis:
Professional drivers are exposed to a number of factors that have a negative influence on their health status. These include vibrations, noise, the lack of fresh air in the car cabin, shift work (frequently at night), monotony resulting from permanent repetition of certain actions, static loads due to immobilization in a sitting position, stress resulting from the need to ensure safety in heavy traffic, as well as air pollution (dust, volatile organic substances, nitrogen and sulfur oxides, polycyclic aromatic hydrocarbons, heavy metals, dioxins, furans and others). Factors associated with the specificity of the profession of a driver, including exposure to chemical substances, result in an increased risk of the development of many diseases, i.e., obesity, diabetes, heart disease, hypertension, extensive genitourinary pathology experienced by taxi drivers, lung cancer and other forms of cancer. In the case of drivers, especially those covering long distances, there are also actual difficulties related to ensuring a proper diet. Although attempts at interventional research that would change the principles of nutrition, as well as ensure physical activity and weight reduction, have been made, their results have not been satisfactory. The paper focuses on the discussion on the role of a diet and dietary phytochemicals in the prevention of adverse health effects of such chemicals as a mix of chemicals in the polluted air, benzo(a)pyrene, benzene and metals (lead, cadmium, chromium, nickel), which are the main sources of exposure in the case of transport workers. Int J Occup Med Environ Health. 2019;32(4):441–64
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2019, 32, 4; 441-464
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clara cells protein, prolactin and transcription factors of protein NF-ĸB and c-Jun/AP-1 levels in rats inhaled to stainless steel welding dust and its soluble form
Autorzy:
Hałatek, Tadeusz
Stanisławska, Magdalena
Świercz, Radosław
Domeradzka-Gajda, Katarzyna
Kuraś, Renata
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2162014.pdf
Data publikacji:
2018-10-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
prolactin
stainless welding
Clara cells protein
NF-kB
c-Jun/AP-1
LA-ICP-MS
Opis:
Objectives Welding processes that generate fumes containing toxic metals, such as hexavalent chromium (Cr(VI)), manganese, and nickel (Ni), have been implicated in lung injury, inflammation, and lung tumor promotion in animal models. Bronchiolar epithelium Clara cells/club cells, coordinate these inflammatory responses. Clara cells secretory protein (CC16) with ant-inflammatory role. Material and Methods The pulmonary toxicity of welding dust (WD) was assessed for Wistar rats exposed to 60 mg/m³ of respirable-size welding dust (mean diameter 1.17 μm for 1 and 2 weeks (6 h/day, 5 days/week)) or the aerosols of soluble form (SWD) in the nose-only exposure chambers. Additionally the effect of antiinflammatory betaine supplementation was assessed. Clara cells secretory protein, differential cell counts, total protein concentrations and cellular enzyme (lactate dehydrogenase – LDH) activities were determined in bronchoalveolar lavage fluid, and corticosterone and thiobarbituric acid reactive substances (TBARS) and prolactin concentrations were assessed in serum. Histopathology examination of lung, brain, liver, kidney, spleen was done. Additionally slices of brain and lung were exanimated in laser ablation inductively coupled plasma mass spectrometry. Results Both WD and SWD exposure evoked large bronchiolar infiltration shoved in histopathology examination. In this study, TBARS inversely correlated with a significant decrease of CC16 concentration that occurred after instillation of both WD and SWD indicating decreased anti- inflammatory potential in the lung. In WD exposed rats prolactin correlated with nuclear factor-kappa B (NF-κB), LDH, TBARS and serum levels Cr, Ni and inversely with c-Jun. In SWD exposed rats prolactin correlated with CC16 indicated effect of prolactin on the population of epithelial cells. Conclusions In the current study, deleterious effects of repeated inhalation stainless steel welding dust form on club (Clara) cell secretory protein (CC16) were demonstrated. Clara cells secretory protein relation with prolactin in exposed rats to welding dust were shown and explored whether the NF-κB and c-Jun/activator protein 1 related pathway was involved. Int J Occup Med Environ Health 2018;31(5):613–632
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 613-632
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Revision of reciprocal action of mercury and selenium
Autorzy:
Kuraś, Renata
Janasik, Beata
Wąsowicz, Wojciech
Stanisławska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/2162011.pdf
Data publikacji:
2018-10-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
gene expression
polymorphism
mercury
selenium
antagonism
interaction
Opis:
Diverse forms of mercury (Hg) have various effects on animals and humans because of a variety of routes of administration. Inorganic mercury (iHg) binds to thiol groups of proteins and enzymes in one’s body or is methylated by microorganisms. Organic form of Hg, contrary to the iHg, is more stable but may be demethylated to Hg2+ in the tissue of intestinal flora. Selenium (Se) also occurs in a variety of chemical forms in one’s body but both of these elements behave very differently from one another. Mercury binding to selenide or Se-containing ligands is a primary molecular mechanism that reduces toxicity of Hg. Complexes formed in such a way are irreversible, and thus, biologically inactive. Se deficiency in a human body may impair normal synthesis of selenoproteins and its expression because expression of mRNA may be potentially regulated by the Se status. This paper provides a comprehensive review concerning Hg–Se reciprocal action as a potential mechanism of protective action of Se against Hg toxicity as well as a potential detoxification mechanism. Although interactions between Hg–Se have been presented in numerous studies concerning animals and humans, we have focused mainly on animal models so as to understand molecular mechanisms responsible for antagonism better. The review also investigates what conclusions have been drawn by researchers with respect to the chemical species of Se and Hg (and their relationship) in biological systems as well as genetic variations and expression and/or activity of selenoproteins related to the thioredoxin (thioredoxin Trx/TrxR) system and glutathione metabolism. Int J Occup Med Environ Health 2018;31(5):575–592
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 575-592
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The distribution and excretion of 1-methylnaphthalene in rats exposed to 1-methylnaphthalene by inhalation
Autorzy:
Świercz, Radosław
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2162034.pdf
Data publikacji:
2018-12-20
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
rats
distribution
inhalation
toxicokinetic
excretion
1-Methylonaphthalene
Opis:
Objectives 1-Methylnaphthalene (1-MN) is a constituent of polycyclic aromatic hydrocarbons, the chemicals that have become ubiquitous in the environment as result of natural and industrial process. This paper reports a study on the distribution and excretion of 1-MN in rats after single and repeated inhalation exposure to 1-MN vapor. Material and Methods Male Wistar rats were exposed to 1-MN vapor at nominal concentrations of 50 mg/m³ or 200 mg/m³ in the dynamic inhalation chambers (TSE Systems Head Nose Only Exposure) for 6 h (single exposure) or 5 days (6 h/day, repeated exposure). Blood, urine and tissue samples were collected during and after the exposure. Blood, urine and tissue concentrations of 1-MN were estimated by gas chromatography using the headspace technique. Results The elimination of 1-MN from blood followed an open 2-compartment model. The concentration in rat tissues was dependent on the magnitude and time of exposure. After repeated exposure, the concentration 1-MN in tissue decreased in comparison to single exposure. The elimination of 1-MN with urine after single and repeated exposure to 1-MN occurred mainly in the samples collected during the first day of collection. Conclusions 1-Methylnaphthalene was rapidly eliminated from the blood and tissues of animals exposed by inhalation to 1-MN. In repeated exposure, there was probably a significant increase of 1-MN metabolism in rats exposed to low and high 1-MN doses. Under conditions of repeated 1-MN exposure, no significant systemic 1-MN accumulation could be observed. Int J Occup Med Environ Health 2018;31(6):763–770
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 6; 763-770
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues
Autorzy:
Król, Magdalena
Galicki, Michał
Grešner, Peter
Wieczorek, Edyta
Jabłońska, Ewa
Reszka, Edyta
Morawiec, Zbigniew
Wąsowicz, Wojciech
Gromadzińska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1038523.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
estrogen receptor
antioxidant enzymes
gene expression
breast cancer tissue
Opis:
Background: The aim of this study was to establish whether the gene expression of estrogen receptor alpha (encoded by ESR1) correlates with the expression of glutathione peroxidase 1 (encoded by GPX1) in the tumor and adjacent tumor-free breast tissue, and whether this correlation is affected by breast cancer. Such relationships may give further insights into breast cancer pathology with respect to the status of estrogen receptor. Methods: We used the quantitative real-time PCR technique to analyze differences in the expression levels of the ESR1 and GPX1 genes in paired malignant and non-malignant tissues from breast cancer patients. Results: ESR1 and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one. Down-regulation of these genes was independent of the tumor histopathology classification and clinicopathological factors, while the ESR1 mRNA level was reduced with increasing tumor grade (G1: 103% vs. G2: 85.8% vs. G3: 84.5%; p<0.05). In the non-malignant and malignant breast tissues, the expression levels of ESR1 and GPX1 were significantly correlated with each other (Rs=0.450 and Rs=0.360; respectively). Conclusion: Our data suggest that down-regulation of ESR1 and GPX1 was independent of clinicopathological factors. Down-regulation of ESR1 gene expression was enhanced by the development of the disease. Moreover, GPX1 and ESR1 gene expression was interdependent in the malignant breast tissue and further work is needed to determine the mechanism underlying this relationship.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 51-57
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Faster health deterioration among nail technicians occupationally exposed to low levels of volatile organic compounds
Autorzy:
Grešner, Peter
Świercz, Radosław
Wąsowicz, Wojciech
Gromadzińska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2167475.pdf
Data publikacji:
2017-05-08
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational exposure
volatile organic compounds
survival analysis
case-control study
adverse health effects
nail technicians
Opis:
Objectives The study has aimed at investigating the subjective assessment of an individual’s health status and comparing the prevalence of selected work-related symptoms among nail technicians occupationally exposed to volatile organic compounds (VOCs) to the one among control subjects. Associations between occupational exposure to VOCs and the incidence of adverse health effects were also analyzed. Material and Methods The study involved 145 female nail technicians and 152 control subjects. Data on the prevalence of adverse health effects was collected using the researcher- made questionnaire and then analyzed by means of survival analysis methods. Results Only 22% of nail technicians as compared to 45% of control subjects described their current health status as “excellent” or “very good” (odds ratio (OR) = 0.4, 95% confidence interval (CI): 0.2–0.6, p < 0.00005). In general, 61% of nail technicians confirmed to have experienced any out of all symptoms considered in the study since the commencement of the job, which was significantly higher as compared to 17% of control subjects (adjusted OR = 2.8, 95% CI: 2.1–3.7, p < 0.0001). Estimated median length of the employment period free of investigated symptoms was significantly shorter among nail technicians as compared to controls (12 years vs. 33 years, p < 0.0001), consistent with almost 4-times increased hazard of the occurrence of such symptoms among the technicians (hazard ratio (HR) = 3.9, 95% CI: 2.7–5.7, p < 0.0001). Cox proportional hazard regression modeling revealed almost 5-times increased hazard of the occurrence of any symptoms among nail technicians exposed to higher levels of the mixture of VOCs as compared to those exposed to lower levels (HR = 4.9, 95% CI: 1–24.1, p = 0.05). Conclusions All outcomes combined together indicate that nail technicians are subject to faster health deterioration, which may be assumed to be caused by occupational exposure to low levels of VOCs. Int J Occup Med Environ Health 2017;30(3):469–483
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 3; 469-483
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Developmental toxicity of N-methylaniline following prenatal oral administration in rats
Autorzy:
Sitarek, Krystyna
Gromadzińska, Jolanta
Stetkiewicz, Jan
Lutz, Piotr
Król, Magdalena
Domeradzka-Gajda, Katarzyna
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2177441.pdf
Data publikacji:
2016-02-10
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
rat
N-methylaniline
NMA
developmental toxicity
metHb
toxicity
Opis:
Objectives The objective of the study was to assess prenatal toxicity of N-methylaniline (NMA) administered by gavage to pregnant female rats. Material and Methods Pregnant female rats were administered N-methylaniline in corn oil by gavage at daily doses of 0.8 mg/kg of body weight (b.w.), 4 mg/kg b.w., 20 mg/kg b.w. and 100 mg/kg b.w. from implantation (the 5th day post mating) to the day prior to the scheduled caesarean section (the 20th day of pregnancy). General behavior, body weight, food and water consumption, hematological, biochemical analyses and pathomorphological changes of the dams were recorded. Results All the females survived until the end of the study. The test substance was toxic to pregnant females, even at the lowest of the used doses, i.e., 0.8 mg/kg b.w./day. Lower weight gain during pregnancy and significantly higher NMA-dose-dependent absolute weight of the organs were noted in the exposed females. The females from the groups exposed at doses of 20 mg/kg b.w./day and 100 mg/kg b.w./day developed anemia and showed higher concentrations of free thyroxine (FT3) and free triiodothyronine (FT4) thyroid hormones. Total protein concentration exhibited an increase in all the exposed groups of females. In the prenatal toxicity study, administration of N-methylaniline throughout the embryonic and fetal periods produced embryotoxic effects at doses ranging 4–100 mg/kg b.w./day. Conclusions Considering the data obtained in this study, it is reasonable to assume that N-methylaniline administered orally to pregnant rats is toxic for mothers even at a low dose of 0.8 mg/kg b.w./day. However, this dose was not associated with any significant effects to their offspring. This prenatal exposure level may be considered as no-observed-adverse-effect level (NOAEL) for the progeny and a dose of 4 mg/kg b.w./day as the lowest-observed-adverse-effect level (LOAEL) for the progeny.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 3; 479-492
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polish Mother and Child Cohort Study (REPRO_PL) – Methodology of the follow-up of the children at the age of 7
Autorzy:
Polańska, Kinga
Hanke, Wojciech
Król, Anna
Potocka, Adrianna
Waszkowska, Małgorzata
Jacukowicz, Aleksandra
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Jerzyńska, Joanna
Stelmach, Włodzimierz
Stelmach, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/2168369.pdf
Data publikacji:
2016-11-18
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
lifestyle
exposure
neurodevelopment
birth cohort
follow-up of children
child’s health
Opis:
Effects of environmental exposures in utero and in the first years of life on early life health and development is a growing research area with major public health implications. The main aim of this work has been to provide an overview of the next step of the Polish Mother and Child Cohort Study (REPRO_PL) covering exposure, health and neurodevelopment assessments of children at 7 years of age. Details regarding methodology of the follow-up of the children are crucial for cross-cohort collaboration and a full understanding of the future research questions. Phase III of the REPRO_PL cohort covers a follow-up of 900 children at the age of 7 years old. The questionnaire filled in by the mothers is composed of: socio-demographic, child exposure and home environment information, nutritional status and health data. In the case of 400 children, environmental (including collection of urine, saliva and buccal cells), health status and psychomotor assessments are performed. Health and development check consists of physical measurements, child health status assessment (including lung function tests, skin prick testing, an interview/examination by an allergist) and psychomotor development tests (the Strength and Difficulties Questionnaire and the Intelligence and Development Scales). The results of the study will become available within the next few years. Extension of the REPRO_PL cohort with examinations of children at the age of 7 years old may provide a better understanding of the relationship between environmental and lifestyle-related factors and children’s health and neurodevelopment; and may further strengthen scientific base for policies and interventions promoting healthy lifestyle. Int J Occup Med Environ Health 2016;29(6):883-893
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 6; 883-893
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene
Autorzy:
Świercz, Radosław
Majcherek, Wanda
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2177094.pdf
Data publikacji:
2015-10-08
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
rats
hemimellitene
pseudocumene
mesitylene
inhalation
toxicokinetic
Opis:
Objectives The aim of the study has been to explore hemimellitene distribution in blood, liver, lung and kidney as well as toxicokinetics of its elimination from blood of rats after single and repeated inhalation exposure to this compound. Tissue distribution and excretion with urine of 2-dimethylbenzoic acids (2,3-DMBA and 2,6-DMBA) were also evaluated. Material and Methods Male outbred IMP:WIST rats were used in the experiment. The animals were exposed to hemimellitene vapors at the nominal concentration of 25 ppm, 100 ppm, and 250 ppm in the dynamic inhalation chambers for 6 h for single exposure purpose and for 4 weeks (6 h/day for 5 day/week) for repeated exposure purposes. Results Significantly lower concentrations of hemimellitene were detected in the blood and tissues of animals after repeated inhalation exposure of animals to hemimellitene vapors, which points to reduced retention of the chemical in the lungs of the experimental rats. The trend of hemimellitene elimination from the blood depended solely on exposure intensity, irrespective of exposure time, both after single and repeated exposure. As regards the 2 determined hemimellitene metabolites, the major trend of the metabolic transformation involved formation of 2,3-DMBA. Conclusions The significantly higher urinary 2,3-DMBA concentration after repeated exposure shows that hemimellitene induces enzymatic processes in the rat.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 1; 113-128
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunostymulacja przy użyciu antygenów bakteryjnych – mechanizm działania i praktyka kliniczna w wirusowych zakażeniach układu oddechowego
Immunostimulation using bacterial antigens – mechanism of action and clinical practice in viral respiratory tract infections
Autorzy:
Feleszko, Wojciech
Dziekiewicz, Marcin
Wąsowicz, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1033870.pdf
Data publikacji:
2015
Wydawca:
Medical Communications
Tematy:
OM-85
bacterial lysates
respiratory tract infections
toll-like receptors
zakażenia układu oddechowego
lizaty bakteryjne
om-85
receptory toll-podobne
Opis:
Recurrent respiratory tract infections constitute a significant problem in the practice of a general practitioner and paediatrician. Antibiotic resistance of bacterial strains, which has been growing for years, prompts the search for alternative ways of combating pathogens. One of them is the usage of preparations based on cell lysis of various bacterial strains. Bacterial lysates have been available in Europe for many years. In preclinical trials, they are characterised by the capability of reducing infections caused by bacteria and viruses that are not the components of the preparations. A range of clinical trials have demonstrated their usefulness in reducing the frequency of seasonal respiratory tract infections and antibiotic use. Moreover, patients with chronic obstructive pulmonary disease gain an additional advantage in the form of the reduction of the risk of hospitalization due to disease exacerbations and a positive influence on the survival curve. The action of bacterial lysates is based on oral immunostimulation of gut-associated lymphoid tissue, which results in increased antibody production. Moreover, they activate a range of mucosal mechanisms of non-specific immunity, mainly by enhancing the activity of TLR-dependent mechanisms. The efficacy of this group of drugs has been confirmed in a range of clinical trials, systematic reviews and meta-analyses. Recent studies also indicate their immunoregulatory potential, suggesting that they might be used in the future in preventing allergies, asthma and autoimmune diseases. To conclude, physicians (paediatricians, laryngologists, pulmonologists) should consider reducing the use of antibiotics in their daily practice. Instead, they should offer preparations that promote the immune system, thus controlling infections in a better way.
Nawracające zakażenia układu oddechowego stanowią istotny problem w codziennej praktyce lekarza rodzinnego i pediatry. Narastająca od lat oporność szeregu szczepów bakteryjnych na antybiotyki każe poszukiwać alternatywnych dróg walki z drobnoustrojami. Taką metodą jest stosowanie preparatów wytwarzanych w oparciu o lizę komórek wielu szczepów bakteryjnych. Lizaty bakteryjne są grupą leków dostępnych w Europie od wielu lat i w badaniach przedklinicznych charakteryzują się zdolnością do ograniczenia zakażeń wywoływanych przez wirusy oraz bakterie inne niż te, które są składnikiem preparatu. W szeregu badań klinicznych udowodniono ich przydatność w ograniczaniu częstości sezonowych zakażeń w układzie oddechowym oraz spożycia antybiotyków. U chorych z przewlekłą obturacyjną chorobą płuc dodatkowym atutem było obniżenie ryzyka hospitalizacji wynikającej z zaostrzenia choroby podstawowej oraz dodatni wpływ na krzywą przeżycia. Działanie lizatów bakteryjnych opiera się na doustnej immunostymulacji tkanki limfatycznej związanej z przewodem pokarmowym, czego skutkiem jest zwiększona produkcja przeciwciał. Ponadto aktywują one szereg śluzówkowych mechanizmów odporności nieswoistej, głównie przez zwiększanie aktywności mechanizmów zależnych od receptorów TLR. Skuteczność tej grupy leków potwierdzono w szeregu badań klinicznych, przeglądów systematycznych oraz metaanaliz. Badania ostatnich lat wskazują także na potencjał immunoregulatorowy, jaki niosą ze sobą te preparaty, wskazując na możliwość ich stosowania w przyszłości w zapobieganiu alergii, astmie i chorobom z autoimmunizacji. Konkludując, warto rozważyć w codziennej praktyce lekarskiej (pediatry, laryngologia, pneumonologa) ograniczanie stosowania antybiotyków, w to miejsce oferując preparaty wspomagające układ odpornościowy w celu lepszej kontroli zakażeń.
Źródło:
Pediatria i Medycyna Rodzinna; 2015, 11, 4; 358-364
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Today’s oxidative stress markers
Współczesne markery stresu oksydacyjnego
Autorzy:
Czerska, Marta
Mikołajewska, Karolina
Zieliński, Marek
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2165384.pdf
Data publikacji:
2015-07-09
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
izoprostany
stres oksydacyjny
markery stresu oksydacyjnego
alantoina
metabolity izoprostanów
isoprostanes
Oxidative stress
oxidative stress markers
allantoin
metabolites of isoprostanes
Opis:
Oxidative stress represents a situation where there is an imbalance between the reactive oxygen species (ROS) and the availability and the activity of antioxidants. This balance is disturbed by increased generation of free radicals or decreased antioxidant activity. It is very important to develop methods and find appropriate biomarkers that may be used to assess oxidative stress in vivo. It is significant because appropriate measurement of such stress is necessary in identifying its role in lifestyle-related diseases. Previously used markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS) or malondialdehyde (MDA), are progressively being supplemented by new ones, such as isoprostanes (IsoPs) and their metabolites or allantoin. This paper is focusing on the presentation of new ones, promising markers of oxidative stress (IsoPs, their metabolites and allantoin), taking into account the advantage of those markers over markers used previously. Med Pr 2015;66(3):393–405
Stres oksydacyjny jest stanem braku równowagi między działaniem reaktywnych form tlenu (RFT) a działaniem antyoksydantów. Równowaga ta może być zakłócona w wyniku zwiększonego działania wolnych rodników lub spadku aktywności antyoksydacyjnej. Zaburzenia te mogą występować zarówno na poziomie komórkowym, jak i całego organizmu. Ponieważ stres oksydacyjny może być podłożem wielu zespołów chorobowych, niezwykle istotne jest znalezienie odpowiednich markerów, które mogą być wykorzystane do oceny jego poziomu in vivo. Stosowane od wielu lat markery – ocenę stężenia aldehyd dimalonowy (MDA) i substancji reagujących z kwasem tiobarbiturowym (thiobarbituric acid reactive substances – TBARS) – stopniowo uzupełnia się nowymi, takimi jak alantoina czy izoprostany (IzoP) wraz z ich metabolitami (IzoP-M). W niniejszej pracy skupiono się na zaprezentowaniu nowych, obiecujących markerów stresu oksydacyjnego (alantoina, IzoP, IzoP-M), ukazując korzyści wynikające z ich stosowania i prognozując dalsze kierunki badań nad ich zastosowaniem. Med. Pr. 2015;66(3):393–405
Źródło:
Medycyna Pracy; 2015, 66, 3; 393-405
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
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