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Wyświetlanie 1-5 z 5
Tytuł:
Role of Escherichia coli heat shock proteins IbpA and IbpB in protection of alcohol dehydrogenase AdhE against heat inactivation in the presence of oxygen
Autorzy:
Matuszewska, Ewelina
Kwiatkowska, Joanna
Ratajczak, Elżbieta
Kuczyńska-Wiśnik, Dorota
Laskowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1040618.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
AdhE
protein aggregation
protein oxidation
small heat shock proteins IbpA and IbpB
Opis:
Escherichia coli small heat shock proteins IbpA and IbpB are molecular chaperones that bind denatured proteins and facilitate their subsequent refolding by the ATP-dependent chaperones DnaK/DnaJ/GrpE and ClpB. In vivo, the lack of IbpA and IbpB proteins results in increased protein aggregation under severe heat stress or delayed removal of aggregated proteins at recovery temperatures. In this report we followed the appearance and removal of aggregated alcohol dehydrogenase, AdhE, in E. coli submitted to heat stress in the presence of oxygen. During prolonged incubation of cells at 50°C, when AdhE was progressively inactivated, we initially observed aggregation of AdhE and thereafter removal of aggregated AdhE. In contrast to previous studies, the lack of IbpA and IbpB did not influence the formation and removal of AdhE aggregates. However, in ΔibpAB cells AdhE was inactivated and oxidized faster than in wild type strain. Our results demonstrate that IbpA and IbpB protected AdhE against thermal and oxidative inactivation, providing that the enzyme remained soluble. IbpA and IbpB were dispensable for the processing of irreversibly damaged and aggregated AdhE.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 55-61
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The multi-raw material documentation as the basis for a comprehensive and rational use of mineral deposit resources on the example of the area of the Bełchatów lignite deposit
Wielosurowcowe dokumentowanie podstawą kompleksowego i racjonalnego wykorzystania zasobów złóż kopalin na przykładzie obszaru złoża węgla brunatnego Bełchatów
Autorzy:
Hycnar, Elżbieta
Ratajczak, Tadeusz
Uberman, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/27311653.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Instytut Gospodarki Surowcami Mineralnymi i Energią PAN
Tematy:
multimineral deposit
multi raw material deposit
multimineral documentation
multi raw material concession
accompanying mineral
złoże wielosurowcowe
złoże wielokopalinowe
dokumentacja wielosurowcowa
koncesja wielosurowcowa
kopalina towarzysząca
Opis:
The domestic (Polish) lignite deposits, including the Bełchatów deposit, are classified as multi-mineral and multi-raw materials. Ensuring the possibility of using a significant part of all minerals present in this type of deposits should be a matter of priority for mines. Over several dozen years of operation, the Bełchatów Lignite Mine, based on its own experience in documenting and exploiting both the main mineral and accompanying minerals, as well as rock mass components that are not solid minerals, this mine has developed a new approach to the problem of the comprehensive use of deposit resources. The content of the article is an attempt to answer the question: do the applicable laws guarantee a comprehensive and rational use of mineral deposits whose resources are non-renewable? On the example of the area of the Bełchatów lignite deposit, the comprehensive and rational use of mineral resources was analysed. It was indicated that the reasons for their use result from the lack of appropriate organizational, economic and financial solutions. Particular attention was paid to the need to modify the licensing procedures for prospecting, documenting and extracting minerals. It seems reasonable to introduce multi-resource concessions, which are an important element of the circular economy. Therefore, proposals were formulated regarding the introduction of additional legal regulations and instruments of an economic and financial nature. These would be able to guarantee the comprehensive and rational use of most mineral resources.
Krajowe złoża węgla brunatnego, w tym również złoże Bełchatów, zalicza się do odmian wielokopalinowych i wielosurowcowych. Zapewnienie możliwości wykorzystania znaczącej części wszystkich kopalin występujących w tego typu złożach powinno być jednym z priorytetowych zadań realizowanych przez kopalnie. W czasie kilkudziesięciu lat funkcjonowania Kopalni Węgla Brunatnego Bełchatów, w oparciu o własne doświadczenia związane z dokumentowaniem i eksploatacją zarówno kopaliny głównej, jak i kopalin towarzyszących, a także składników górotworu, które nie są kopalinami stałymi, kopalnia ta wypracowała nowe podejście do problemu kompleksowego wykorzystania zasobów złoża. Treść artykułu jest próbą odpowiedzi na pytanie: czy obowiązujące przepisy prawa gwarantują kompleksowe i racjonalne wykorzystanie złóż kopalin, których zasoby są nieodnawialne? Na przykładzie obszaru złoża węgla brunatnego Bełchatów dokonano analizy kompleksowego i racjonalnego wykorzystania zasobów kopalin. Wskazano, że przyczyny niedostatecznego wykorzystania zasobów mineralnych wynikają z braku odpowiednich rozwiązań organizacyjnych, ekonomicznych i finansowych. Szczególną uwagę zwrócono na konieczność modyfikacji procedur koncesyjnych na poszukiwanie, dokumentowanie i wydobywanie kopalin. Racjonalne wydaje się wprowadzenie koncesji wielosurowcowych, które są ważnym elementem gospodarki w obiegu zamkniętym. Dlatego sformułowano propozycje wprowadzenia dodatkowych regulacji prawnych oraz instrumentów o charakterze ekonomiczno-finansowym. Będą one w stanie zagwarantować kompleksowe i racjonalne wykorzystanie większości zasobów mineralnych występujących w złożu.
Źródło:
Gospodarka Surowcami Mineralnymi; 2023, 39, 3; 27--42
0860-0953
Pojawia się w:
Gospodarka Surowcami Mineralnymi
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of olanzapine and aripiprazole on spatial memory of female rats exposed to stress in the perinatal period
Autorzy:
Kus, Krzysztof
Ratajczak, Piotr
Zaprutko, Tomasz
Kopciuch, Dorota
Paczkowska, Anna
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895623.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
olanzapine
aripiprazole
Prenatal stress
female rats
variation in sexes
Opis:
Cognitive functions, such as learning and memory, are instrumental in improving the patient’s quality of life. Commonly used antipsychotic drugs are also useful in depression treatment, and have a positive effect on spatial memory dysfunction caused by schizophrenia. Olanzapine (OLA) and aripiprazole (ARI) are known to have substantially different pharmacokinetics depending on sex, thus their therapeutic efficacy and dose of treatment may be different for males and females. The aim of the study was to assess whether dysfunction of spatial memory (Morris Water Maze - MWM) and locomotor activity (LA) improve in prenatally stressed rats (animal model of schizophrenia (AMS)) by OLA and ARI. OLA (0.5 mg/kg ip) and ARI (1.5 mg/kg ip) were administered to female Wistar rats (non-stressed control group (NSCG) and PSG). Single administration of ARI and OLA in the NSCG yielded no differences in spatial memory compared to the control group (C-NSCG), while OLA improved memory after 7 days of treatment compared to the C-NSCG. In the prenatally stressed group (PSG), an impairment of spatial memory by the drug was observed (vs. C-NSCG) after long-term treatment. Only chronic administration of ARI and OLA (PSG) improved spatial memory in female rats. Conclusion: Stress causes memory dysfunction in female rats. Chronic administration of ARI and OLA reverses this effect which can probably be associated with the mechanism of action of the drugs used (ARI/OLA). ARI acts as an agonist or antagonist mainly on D2 and 5-HT2A receptors, while OLA induces antagonist effects for these receptors.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 885-893
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE PRESCRIPTION TO OVER-THE-COUNTER SWITCHES AND DOUBLE REGISTRATION OF MEDICINES - THE PERSPECTIVE OF PHARMACISTS FROM THE GREATER POLAND.
Autorzy:
Zaprutko, Tomasz
Kopciuch, Dorota
Ratajczak, Piotr
Paczkowska, Anna
Adamczak, Olga
Kus, Krzysztof
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895258.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
pharmaceutical market
pharmacies
Rx-to-OTC switches
double registration
Opis:
The prescription to over-the-counter switch is a global occurrence. However, the switch phenomenon might be considered controversial. Nevertheless, the further development of switches seems to be inevitable, thus we collected pharmacists’ opinions about Rx-to-OTC switches including double registration of medicines. The study was conducted in pharmacies from the Greater Poland, using an anonymous questionnaire, which was delivered by direct contact. Finally, answers from 232 pharmacies were included in the study. Moreover, we analyzed data from 5500 Polish pharmacies, concerning the turnover of selected and doubly registered medicines. Rx-to-OTC switches were negatively evaluated by the majority (81.5%) of respondents. “Furaginum” was the most frequently chosen (60.8%) substance, which according to obtained answers should be available only on prescription. Study participants claimed that the most important drawback (chosen by 44.4% participants) of the double registration of medicines is the development of uncontrolled self-medication. Data obtained from a market research company revealed that the Rx-to-OTC switch may lead to the market share growth of OTC class (e.g. “furaginum”), but it is not the rule (e.g. “omeprazole/pantoprazole”). Although Rx-to-OTC switches are considered somewhat controversial, the switch, as well as double registration phenomenon, seems to be a subject of further development. However, in pharmacists opinion substances like “furaginum” should be available as an Rx-only brand instead of double registered medicine. In the case of Rx-to-OTC switches, additional information about possible side effects and/or interactions should be provided to the patients who might inappropriately use medicines.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 907-912
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Crystal Lattice Damage and Recovery of Rare-Earth implanted Wide Bandgap Oxides
Autorzy:
Sarwar, Mahwish
Ratajczak, Renata
Ivanov, Vitalii
Mishra, Sushma
Turek, Marcin
Wierzbicka, Aleksandra
Woźniak, Wojciech
Guziewicz, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/2204945.pdf
Data publikacji:
2022
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
wide bandgap oxides
zinc oxide
gallium oxide
rare earth
ion implantation
Rutherford backscattering spectrometry
low temperature photoluminescence
Opis:
Rare earth (RE) elements are important for the optical tuning of wide bandgap oxides (WBO) such as β-Ga2O3 or ZnO, because β-Ga2O3:RE or ZnO:RE show narrow emission lines in the visible, ultra-violet and infra-red region. Ion implantation is an attractive method to introduce dopant into the crystal lattice with an extraordinary control of the dopant ion composition and location, but it creates the lattice damage, which may render the dopant optically inactive. In this research work, we investigate the post-implantation crystal lattice damage of two matrices of wide-bandgap oxides, β-Ga2O3 and ZnO, implanted with rare-earth (RE) to a fluence of 5 x 10^14, 1 x 10^15 and 3 x 10^15 atoms/cm^2, and post-growth annealed in Ar and O2 atmosphere, respectively. The effect of implantation and annealing on both crystal lattices was investigated by channeling Rutherford backscattering spectrometry (RBS/C) technique. The level of crystal lattice damage caused by implantation with the same RE fluences in the case of β-Ga2O3 seems to be higher than in the case of ZnO. Low temperature photoluminescence was used to investigate the optical activation of RE in both matrices after performed annealing.
Źródło:
Advances in Science and Technology. Research Journal; 2022, 16, 5; 147--154
2299-8624
Pojawia się w:
Advances in Science and Technology. Research Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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