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Wyświetlanie 1-2 z 2
Tytuł:
Knowledge and attitude of primary healthcare workers towards rational prescription of artemisinin-based combination therapy in the treatment of uncomplicated malaria in Ondo State, Southwestern Nigeria
Autorzy:
Oyinaka, B.D.
Umar, N.M.
Aminu, N.
Akinleye, C.A.
Nuhu, T.
Powiązania:
https://bibliotekanauki.pl/articles/2098244.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
Primary Health Care
worker
artemisinin-based combination therapy
knowledge
Ondo State
Nigeria
Opis:
Introduction and objective. For an effective and desired outcome of therapy to be achieved, the technical capacity of the healthcare worker is a key factor. The aim of the study is to assess knowledge and attitudes of primary healthcare (PHC) workers towards rational artemisinin-based combination therapy (ACT) prescribed in the treatment of uncomplicated malaria. Materials and method. This is a descriptive cross-sectional survey in which a self-administered structured questionnaire was used. A combination of stratified and multistage sampling techniques where utilized in the selection of the healthcare workers (HCWs). Results. Of the 422 respondents, 100 (23.7%) were males and 322 (76.3%) were females. Respondents with less than five years in practice accounted for 36%, while 64% had six years and above of practice. Community health extension workers (CHEW) accounted for 54%, while 46% were either community health officers (CHO), nurses, midwives, Bachelors of Science (BSc) in community health, or with other qualifications. A total of 390 (92.4%) were aware of the availability of ACTs and used the malaria treatment protocols, whereas 28 (6.6%) still used monotherapy for simple malaria treatment, and 2.7% did not use any form of test before initiating treatment. Co-administration of non-ACTs with ACTs accounted for 12%, with 88% prescribing paracetamol with ACTs. 67% of the respondents required capacity building in rational ACT use. Conclusion. The majority of the respondents had the requisite knowledge and skills coupled with positive attitudes in prescribing ACTs. Some respondents could not distinguish between an ACTs and a monotherapy. This may affect the exact application of the malaria treatment protocols, especially at the PHC level.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2021, 15, 1; 5-14
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antimicrobial resistant and virulence genes profiles of some Gram-negative bacteria from clinical isolates at Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
Autorzy:
Nuhu, T.
Beng, E.O.B.
Bolaji, R.O.
Olayinka, T.A.
Olayinka, B.O.
Yahaya, M.
Powiązania:
https://bibliotekanauki.pl/articles/2097833.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
virulence factors
Enterobacteriaceae
anti-microbial resistance
north-west Nigeria
Opis:
Introduction and objective. Infections due to multidrug-resistant (MDR) Enterobacteriaceae are an ongoing global threat in their management. The aim of the study was to investigate the antiimicrobial resistance (AMR) and virulence gene profiles of MDR Gram-negative isolates in Sokoto, north-west Nigeria. Materials and method. A total of 578 clinical samples were collected from patients. Suspected Gram-negative bacteria were isolated from these clinical samples: vaginal swab, pus, stool, blood, wound swab and urine, using Gram-staining and conventional biochemical reactions. These isolates were further identified with an identification kit (Microgen-GN-A), and tested against a panel of 11 antibiotics. A single polymerase chain reaction (PCR) assay targeting 13 virulence gene related to adhesion (fimH, papC, and sfaS), iron chelation (iutA, and fyuA), toxins (astA, stx1, stx2, and eaeA), biofilm (bssS), and serum resistance (traT, iss, and kapsMTII) encoding genes were evaluated. Results. A total of 276 Gram-negative isolates were identified using the Gram stain and biochemical reactions. These organisms were further confirmed with identification kit. Of the 276 isolates, 36 organisms of interest (23 Escherichia coli, 4 Klebsiella pneumoniae and 9 Proteus mirabilis) were identified. Other Gram-negative isolates accounted for the remaining 86.9%. The majority of the isolates were resistant to cefixime (100%) and partially resistant to amikacin (19.4%).The virulence genes bssS (58.3%), fimH (44.4%), and iutA (44.4%) were the most prevalent, whereas kapsMTII (5.6%) and stx2 (2.8%) were least detected, while astA was not detected in any of the isolates. Conclusion. The study elucidated the prevalence of antibiotic resistance and virulence genes in Gram-negative bacteria from clinical isolates in Sokoto, north-western Nigeria. The majority of the isolates were MDR, thereby posing a public health risk.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2020, 14, 2; 52-57
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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