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Tytuł:
Wielokryterialna ocena skutków regulacji rzek
MULTI-CRITERIA EVALUATION OF THE EFFECTS OF RIVER REGULATION
Autorzy:
Hachoł, Justyna
Bondar-Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/chapters/2231947.pdf
Data publikacji:
2016
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
ocena wielokryterialna
rośliny wodne
regulacja rzek
Opis:
W pracy podjęto próbę oceny skutków wykonania robót regulacyjnych w korytach rzecznych w aspekcie bezpieczeństwa powodziowego i ekologicznego. Zgodnie z zasadą zrównoważonego rozwoju, konieczne jest znalezienie kompromisu w tym zakresie. Dlatego w analizie uwzględniono zarówno kryteria techniczne, jak i przyrodnicze. Badania terenowe wykonano w okresach wegetacyjnych w latach 2008–2014, w małych i średnich ciekach nizinnych Dolnego Śląska, w których wykonano roboty regulacyjne. Zakres tych robót był zróżnicowany. Badania terenowe obejmowały pomiar i opis wybranych technicznych i przyrodniczych elementów złożonego systemu koryta cieku, takich jak: spadek podłużny, szerokość dna, głębokość koryta, nachylenie i sposób umocnienia skarp, substrat dna, zacienienie koryta, naturalne elementy w korycie, liczba gatunków naczyniowych roślin wodnych oraz stopień pokrycia przez nie dna cieku. Na podstawie wyników badań dokonano wielokryterialnej oceny skutków robót. W tym celu zastosowano metodę unitaryzacji zerowanej. Pozwoliło to utworzyć liniowy ranking koryt rzecznych oraz wskazać optymalne rozwiązanie w aspekcie zrównoważonego rozwoju.
The study presents an attempt of evaluation of the effects of the regulatory works in river beds in terms of the flood protection and the ecological safety. In accordance with the principle of sustainable development it is necessary to find a compromise in this regard. Therefore, the analysis takes into account both the technical criteria, as well as the natural criteria. The field studies were conducted in growing seasons in years 2008–2014 on four small and medium-sized lowland watercourses in Lower Silesia region, where the regulation works have been performed. The range of these works was varied. The study included measurements and description of selected technical and natural elements of complex stream bed system, such as: longitudinal profile, bottom width, watercourse depth, bank slope, type of bank protection, type of bottom substrate, the degree of shading, natural elements in the watercourse bed, number of aquatic plants species and bottom coverage with the plants. Based on the results of the study the multi-criteria evaluation of the effects of river regulation was performed. Analysis was performed with the use of the Zero Unitarization Method. It allowed to determine a linear ranking of the river beds and to identify the optimal solution in terms of the sustainable development.
Źródło:
Interdyscyplinarne zagadnienia w inżynierii i ochronie środowiska 8; 108-119
9788374939447
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena dostępności ekonomicznej pacjentów do wybranych grup leków w rocznej perspektywie od wprowadzenia nowej ustawy refundacyjnej
Autorzy:
Zaprutko, Tomasz
Nowakowska, Elżbieta
Kus, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/635227.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
economic availability, pharmacotherapy, reimbursement
Opis:
The evaluation of the patients economic availability to some groups of medicines. One year follow up of a new reimbursement systemChanges in the organization and financing of the public health care are always a reason of the social restlessness. The same situation was observed in Poland where at the beginning of 2012 a new reimbursement system was introduced. Therefore the main aim of this paper is to verify economic availability of patients to medicines after implementation of the changes. The annual research perspective ensures the reliability of analysis. The study concerns 11 medicines and was conducted using official announcements of the Polish Minister of Health. Due to changes introduced by the Polish government, prices of some drugs have been permanently reduced. But in some analyzed cases (olanzapine) reduction is not sufficient. Some medicines, like gosereline were significantly more expensive in 2012 than in 2011. Although the new reimbursement system has a lot of advantages, further studies and amendments are necessary to provide a real economic availability to many important medicines.
Źródło:
Zdrowie Publiczne i Zarządzanie; 2013, 11, 1
2084-2627
Pojawia się w:
Zdrowie Publiczne i Zarządzanie
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Management of Alterations to Project Documentation – a Case Study of Water Supply and Sewerage Works
Autorzy:
Rybka, Iwona
Bondar-Nowakowska, Elżbieta
Połoński, Mieczysław
Powiązania:
https://bibliotekanauki.pl/articles/683561.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
project documentation, water supply and sewerage works, management of alterations
Opis:
Background. The implementation of alterations to project documentation is the modification of certain solutions, assumptions or requirements. It mostly involves the verification or the specification of project documentation with regard to the actual conditions of execution or the investor’s expectations. The management of alterations in a construction project is aimed at predicting any negative consequences caused by changes in the investment process and their prevention or mitigation. Previous experience indicates that alterations to project documentation introduced during the execution of the work are widespread. They contribute to loss of time and increase in the cost of the project. For this reason, it is necessary to develop and implement an effective model for the management of such alterations.Research aims. The project manager, before construction, should be aware of any alterations to the project documentation that may have occurred during its execution, and their possible consequences. The aim of the study is to identify the causes, the structure and the consequences of alterations to project documentation with regard to water supply and sewerage construction.Methodology. The basis of the research and analyses constitute a detailed review of documentation compiled from eight projects in water supply and sewerage. Among the documents concerned, the “Records of Necessity” and “Records of Negotiations” were especially valuable for conducting the analysis.Key findings. The research conducted indicated the crucial role of the investor in the process of managing alterations to project documentation. The research revealed that proper preparation of the investment process, i.e. recruiting the best designers to prepare the project documentation, tracking changes in the nearer and farther surroundings, may significantly contribute to reducing or even eliminating many alterations to project documentation during the execution of the work.
Źródło:
International Journal of Contemporary Management; 2015, 14, 3
2449-8920
Pojawia się w:
International Journal of Contemporary Management
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of olanzapine and aripiprazole on spatial memory of female rats exposed to stress in the perinatal period
Autorzy:
Kus, Krzysztof
Ratajczak, Piotr
Zaprutko, Tomasz
Kopciuch, Dorota
Paczkowska, Anna
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895623.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
olanzapine
aripiprazole
Prenatal stress
female rats
variation in sexes
Opis:
Cognitive functions, such as learning and memory, are instrumental in improving the patient’s quality of life. Commonly used antipsychotic drugs are also useful in depression treatment, and have a positive effect on spatial memory dysfunction caused by schizophrenia. Olanzapine (OLA) and aripiprazole (ARI) are known to have substantially different pharmacokinetics depending on sex, thus their therapeutic efficacy and dose of treatment may be different for males and females. The aim of the study was to assess whether dysfunction of spatial memory (Morris Water Maze - MWM) and locomotor activity (LA) improve in prenatally stressed rats (animal model of schizophrenia (AMS)) by OLA and ARI. OLA (0.5 mg/kg ip) and ARI (1.5 mg/kg ip) were administered to female Wistar rats (non-stressed control group (NSCG) and PSG). Single administration of ARI and OLA in the NSCG yielded no differences in spatial memory compared to the control group (C-NSCG), while OLA improved memory after 7 days of treatment compared to the C-NSCG. In the prenatally stressed group (PSG), an impairment of spatial memory by the drug was observed (vs. C-NSCG) after long-term treatment. Only chronic administration of ARI and OLA (PSG) improved spatial memory in female rats. Conclusion: Stress causes memory dysfunction in female rats. Chronic administration of ARI and OLA reverses this effect which can probably be associated with the mechanism of action of the drugs used (ARI/OLA). ARI acts as an agonist or antagonist mainly on D2 and 5-HT2A receptors, while OLA induces antagonist effects for these receptors.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 885-893
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE PRESCRIPTION TO OVER-THE-COUNTER SWITCHES AND DOUBLE REGISTRATION OF MEDICINES - THE PERSPECTIVE OF PHARMACISTS FROM THE GREATER POLAND.
Autorzy:
Zaprutko, Tomasz
Kopciuch, Dorota
Ratajczak, Piotr
Paczkowska, Anna
Adamczak, Olga
Kus, Krzysztof
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895258.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
pharmaceutical market
pharmacies
Rx-to-OTC switches
double registration
Opis:
The prescription to over-the-counter switch is a global occurrence. However, the switch phenomenon might be considered controversial. Nevertheless, the further development of switches seems to be inevitable, thus we collected pharmacists’ opinions about Rx-to-OTC switches including double registration of medicines. The study was conducted in pharmacies from the Greater Poland, using an anonymous questionnaire, which was delivered by direct contact. Finally, answers from 232 pharmacies were included in the study. Moreover, we analyzed data from 5500 Polish pharmacies, concerning the turnover of selected and doubly registered medicines. Rx-to-OTC switches were negatively evaluated by the majority (81.5%) of respondents. “Furaginum” was the most frequently chosen (60.8%) substance, which according to obtained answers should be available only on prescription. Study participants claimed that the most important drawback (chosen by 44.4% participants) of the double registration of medicines is the development of uncontrolled self-medication. Data obtained from a market research company revealed that the Rx-to-OTC switch may lead to the market share growth of OTC class (e.g. “furaginum”), but it is not the rule (e.g. “omeprazole/pantoprazole”). Although Rx-to-OTC switches are considered somewhat controversial, the switch, as well as double registration phenomenon, seems to be a subject of further development. However, in pharmacists opinion substances like “furaginum” should be available as an Rx-only brand instead of double registered medicine. In the case of Rx-to-OTC switches, additional information about possible side effects and/or interactions should be provided to the patients who might inappropriately use medicines.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 907-912
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ANALYSIS OF CHRONIC MYELOID LEUKEMIA PHARMACOTHERAPY COSTS IN POLAND
Autorzy:
Paczkowska, Anna
Kus, Krzysztof
Nowicka, Monika
Kopciuch, Dorota
Zaprutko, Tomasz
Komarnicki, Mieczysław
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895298.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
poland
chronic myeloid leukemia
stem cell transplantation
pharmacotherapy cost analysis
Opis:
The aim of this study was to analyze pharmacotherapy cost of chronic myeloid leukemia from the society’s, the payer’s (National Health Fund), and the patient’s perspective. The study included 55 patients with a diagnosed and treated chronic myeloid leukemia at the selected hematology clinic in the city of Poznan. Retrospective study involved time horizon of one calendar year – 2013. The data required for economic evaluation were obtained from the patients’ case histories and the Department of Organization and Accounting of the selected health care facilities. The total cost of chronic myeloid leukemia pharmacotherapy for 55 patients from the society’s perspective in 2013 amounted to 1,483,416.88 EUR. Average annual cost of medication per patient in 2013 amounted to 26,971.22 EUR (Median – 32,854.22 EUR). Average cost of chronic myeloid leukemia pharmacotherapy for a patient without transplantation was 32,167.34 EUR (Median – 30,623.00 EUR), and for a patient after transplantation amounted to 413.13 EUR (Median – 378.40 EUR). The cost from the payer’s perspective is 99.93% of total costs from the society’s perspective. The cost from the patient’s perspective represents 0.07% of the total cost of chronic myeloid leukemia pharmacotherapy from the society’s perspective. Costs of chronic myeloid leukemia pharmacotherapy are very high and represent a significant burden to society. The highest costs associated with treatment of chronic myeloid leukemia are incurred by the society, and, subsequently, the public payer (NHF), and the patient.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 175-183
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Employment in schizophrenia –students’ point of view
Autorzy:
Zaprutko, Tomasz
Kopciuch, Dorota
Sawicka, Dominika
Majchrzycka, Blanka
Nowak, Michał
Michalak, Michał
Kus, Krzysztof
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895547.pdf
Data publikacji:
2018-06-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
schizophrenia
students
employment
European Union
opinions
Opis:
Schizophrenia is a serious mental disorder and has a huge economic burden related to direct and indirect costs. Direct costs include such expenditure as hospitalization. Indirect costs, however, result mostly from the loss of productivity. Although patients are frequently interested in job opportunities, unemployment is widespread among them. Thus, we evaluated opinions of medical universities students’ concerning situation on the labor market among those in the remission stage of schizophrenia. The study was carried out between October 2015 and October 2016 in Poland and other European Union countries using a self designed questionnaire. The study tool consisting of five questions was distributed to students by direct contact and via the Internet. Of a 5200 distributed sheets, we received 1036 questionnaires and 942 were finally analyzed. In the students’ opinion, patients are generally interested in finding a job but they are afraid coming back to work. Although unemployment is common among patients with schizophrenia, the number of patients capable of working is significantly higher than the number of those actually employed. According to results of the study, getting a job might be effectively supported by non-pharmacological interventions. Considering the noticeably higher number of patients capable of working compared to those employed, development of employment possibilities should be a priority for mental health care decision makers. It should lead to reduction of the patients’ concerns related to looking for a job. Moreover, comprehensive treatment could reduce the economic burden of schizophrenia.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3; 813-818
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Access to vaccination in the Greater Poland (Poland)
Autorzy:
Zaprutko, Tomasz
Kopciuch, Dorota
Paczkowska, Anna
Sawicka, Dominika
Stachowiak, Zuzanna
Bogdaniec, Patrycja
Kus, Krzysztof
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895651.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
poland
vaccines
access
pharmaceutical market
pharmacies
Opis:
Immunization is a very effective health intervention. Moreover, the global vaccines market has been growing rapidly and costs of full children immunization are dramatically higher nowadays than 30 years ago. High vaccine prices may limit affordability of vaccination which is why we attempted an evaluation of availability and affordability of 7 and non-reimbursed vaccines mostly used in children in Poland. The study was conducted between October 2016 and October 2017 using a specially designed anonymous questionnaire comprising three closed-ended questions. The study tool was distributed by direct contact or via the Internet. Eventually, answers from 505 pharmacies from the Greater Poland region and 10 primary care clinics were included. 5 out of 7 vaccines were available in all types of facilities. There were some issues, however, with availability of Bexsero® and Nimenrix®. Considering prices, the highest difference (of more than 100%) was found for Infanrix hexa® and the lowest (38.5%), for Infanrix IPV+HIB®. In 88.17% of pharmacies included, patients were informed about a thermo-insulating package. 48.39% of respondents indicated that such package is free of charge, while in other pharmacies an average price for the package was EUR 0.48. Although availability and affordability of medicines are crucial objectives of the public health policy, it seems that access to vaccines in Poland might be an area for improvement. Thus, prices of non-reimbursed vaccines could be regulated in Poland nationwide. Moreover, to provide trustworthy information concerning vaccination, healthcare decision makers should consider social education about immunization as an important issue.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 195-201
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The correlation analysis of WWOX expression and cancer related genes in neuroblastoma- a real time RT-PCR study
Autorzy:
Nowakowska, Magdalena
Płuciennik, Elżbieta
Wujcicka, Wioletta
Sitkiewicz, Anna
Kazanowska, Bernarda
Zielińska, Elżbieta
Bednarek, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1039340.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
neuroblastoma
WWOX gene
LOH
real time RT-PCR
Opis:
Neuroblastoma is one of the most common paediatric cancers, described as unpredictable due to diverse patterns of behaviour. WWOX is a tumour suppressor gene whose expression is reduced in many tumour types. Loss of its expression was shown to correlate with more aggressive disease stage and mortality rate. The aim of this study was to investigate the role of the WWOX tumour suppressor gene in neuroblastoma formation. We performed real-time RT-PCR to analyse levels of WWOX expression in 22 neuroblastic tumour samples in correlation with genes involved in cell cycle regulation (CCNE1, CCND1), proliferation (MKI67), apoptosis (BCL2, BIRC5, BAX) and signal transduction (EGFR, ERBB4). We also evaluated two potential mechanisms - promoter methylation (MethylScreen method) and loss of heterozygosity (LOH) status, which could be connected with regulation of WWOX gene expression. We found a positive correlation between WWOX gene and BCL2 and HER4 JM-a and negative with cyclin D1 and E1. Our observations are consistent with previous findings and emphasise the role of WWOX in cell cycle and apoptosis regulation. Moreover, strong positive association with HER4 JM-a in this tumour type may indicate a role for WWOX in neuroblastoma cell differentiation. The presented results indicate that LOH in locus D16S3096 (located in intron 8) may be involved in the regulation of WWOX mRNAexpression. However, no association between methylation status of WWOX promoter and its expression was observed.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 91-97
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena znaczenia białka YKL-40 jako biomarkera w raku jelita grubego oraz jego powiązań z wybranymi parametrami kliniczno-patologicznymi
Assessment of importance of YKL-40 protein as biomarker in colorectal cancer and its relation to selected clinical and pathological parameters
Autorzy:
Nadbrzeżna-Barczyk, Dorota
Waniczek, Dariusz
Świętochowska, Elżbieta
Nowakowska-Zajdel, Ewa
Copija, Angelika
Raźnikiewicz, Aleksandra
Rykaczewska-Czerwińska, Monika
Lorenc, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1955194.pdf
Data publikacji:
2021-12-31
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
rak jelita grubego
YKL-40
lokalizacja raka okrężnicy
biomarker nowotworowy
colorectal cancer
colon cancer localization
cancer biomarker
Opis:
WSTĘP: Rak jelita grubego (colorectal cancer – CRC) jest jednym z najczęstszych nowotworów na świecie – odpowiada za 10% rocznej globalnej zapadalności na raka. Przez długi czas może pozostać bezobjawowy i mimo postępu medycyny zbyt często zostaje zdiagnozowany za późno. Białko YKL-40 jest czynnikiem wzrostu stymulującym migrację komórek śródbłonka, odgrywającym rolę w stanach zapalnych oraz nowotworowych. Celem pracy była ocena znaczenia YKL-40 jako biomarkera w CRC oraz określenie powiązań stężeń YKL-40 w surowicy u chorych na CRC z wybranymi parame-trami kliniczno-patologicznymi. MATERIAŁ I METODY: W badaniu prospektywnym, obejmującym 133 osoby powyżej 50 roku życia, oznaczono stężenie białka YKL-40 w surowicy metodą ELISA. Pacjentów podzielono na dwie grupy: 91 osób chorujących na CRC oraz 42 osoby zdrowe. W analizie statystycznej wykorzystano testy t-Studenta dla danych niezależnych, U Manna-Whitneya i regresję logistyczną.WYNIKI: Stężenie YKL-40 w surowicy było znacznie wyższe u chorych na CRC (163 ± 36 μg/l) niż u osób zdrowych (54 ± 20 μg/l; p < 0,0001). U osób z CRC nie wykazano zależności między parametrami klinicznymi, tj. płcią, wiekiem i wskaźnikiem masy ciała (body mass index – BMI), a stężeniem białka YKL-40 w surowicy. U chorych z CRC stężenie YKL-40 w surowicy statystycznie istotnie różniło się we wczesnym i średniozaawansowanym stadium nowotworowym. WNIOSKI: Białko YKL-40 wydaje się obiecującym biomarkerem CRC. Jego stężenie w surowicy jest skorelowane ze stopniem zaawansowania nowotworu zależnie od głębokości nacieku w stosunku do błony podśluzowej i może być czynnikiem rokowniczo niepomyślnym dla tego nowotworu.
INTRODUCTION: Colorectal cancer (CRC) is one of the most common cancers in the world, accounting for 10% of the annual global cancer incidence. This malignant neoplasm can remain asymptomatic for a long time and, despite medical advances, is too frequently diagnosed too late. The YKL-40 protein is a growth factor that stimulates endothelial cell migration, and plays a role in inflammation and neoplasia. The aim of the study was to assess the significance of YKL-40 as a biomarker in CRC and to determine the correlation between the serum YKL-40 levels in CRC patients and selected clinical and pathological parameters. MATERIAL AND METHODS: In a prospective study involving 133 patients over the age of 50, the serum YKL-40 protein level concentration was determined by the ELISA method. The patients were divided into two groups: 91 with CRC and 42 healthy. For the statistical analysis Student's t-test for independent data, the Mann-Whitney U test, and logistics regression were used. RESULTS: The YKL-40 serum concentration was significantly higher in the CRC patients (163 ± 36 μg/l) than the healthy patients (54 ± 20 μg/l; p < 0.0001). There was a statistically significant difference in the serum YKL-40 concentration between the early and intermediate stages of CRC. There was no correlation between the clinical parameters, i.e. sex, age and BMI and the serum YKL-40 protein concentration in the people with CRC. CONCLUSIONS: The YKL-40 protein seems to be a promising CRC biomarker. Its serum concentration is correlated with the stage of the cancer depending on the depth of the growth relative to the submucosa and may be a prognostic factor for an adverse prognosis of this cancer.
Źródło:
Annales Academiae Medicae Silesiensis; 2021, 75; 136-146
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 13

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