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Wyszukujesz frazę "Niekraszewicz, Antoni" wg kryterium: Autor

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    Wyświetlanie 1-9 z 9
    Tytuł:
    POTENTIAL USE OF CHITOSAN – BASED MATERIALE IN MEDICINE
    Autorzy:
    Kucharska, Magdalena
    Ciechańska, Danuta
    Niekraszewicz, Antoni
    Wiśniewska-Wrona, Maria
    Kardas, Iwona
    Powiązania:
    https://bibliotekanauki.pl/articles/1035560.pdf
    Data publikacji:
    2010
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    biomaterials
    medicine
    polysaccharides
    Opis:
    Polysaccharides are macromolecular polymers that manifest ability toward the forming of fibres, film and coatings. Some of their specific properties like biodegradability and biocompatibility make them suitable for medical application. Chitin, chitosan and alginates are basic polymers mostly used in the preparation of medical biomaterials. In the Institute of Biopolymers and Chemical Fibres (IBWCh) multidirectional investigations are in full swing concerned with the use medical of polysaccharides and their various useful forms. The research includes amongst: multifunctional dressing materials, implants and other polysaccharide biomaterials.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 169-176
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of chitosan on the synthesis of l-s-nitrosocysteine that participates in the regulation of the m2 pyruvate kinase isoenzyme activity associated with ehrlich ascites cells proliferation in vitro
    Autorzy:
    Ignacak, Jan
    Zagajewski, Jacek
    Pałka, Iwona
    Wiśniewska-Wrona, Maria
    Niekraszewicz, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1035527.pdf
    Data publikacji:
    2010
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    L-S-nitrosocysteine
    L-cysteine
    inhibition of EAT cell proliferation
    microcrystalline chitosan
    pyruvate kinase M2 isoenzyme
    Opis:
    L-S-nitrosocysteine formation in EAT tumor cells and normal CRL-1636 cells incubated with microcrystalline chitosan was confirmed by RP-HPLC. The metabolite was identified based on UV-VIS spectra. The formation of L-S-nitrosocysteine in EAT tumor cells contributes to decreasing the level of L-cysteine in these cells. L-cysteine as an effector of the bifunctional M2 isoenzyme of pyruvate kinase (PK) initiates its histone kinase activity, which is responsible for histone H1 phosphorylation. A decrease of L-cysteine level in EAT tumor cells contributes to lack of histone H1 phosphorylation by the M2 PK isoenzyme and by the same token to inhibition of EAT cell proliferation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 149-158
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Utilization of biodegradable polymers for peripheral nerve reconstruction
    Autorzy:
    Kardas, Iwona
    Marcol, Wiesław
    Niekraszewicz, Antoni
    Kucharska, Magdalena
    Ciechańska, Danuta
    Wawro, Dariusz
    Lewin-Kowalik, Joanna
    Właszczuk, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1035488.pdf
    Data publikacji:
    2010
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    biodegradable nerve guides
    nerve reconstruction
    polysaccharides
    Opis:
    Peripheral nerve injuries are one of frequent cause of disability. Results of surgical procedures are not still completely satisfactory, though fast development of microsurgical technician improve their efficiency. One of the major problems in surgical treatment of the peripheral nerve injuries is ends coaptation in the case of large loss of nerve tissue. And so finding substitute implants not rejected by the organism for the recipient and providing with the success is necessary of regeneration. Recently, several synthetic nerve guide implants have been introduced and approved for clinical use to replace autologous transplants. This alternative therapy is based on pioneering studies with experimental nerve guides. This paper present a review of published studies involving biodegradable nerve guides.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 159-168
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of chitosan oligomers in regulation of ehrlich ascites tumor cells proliferation in vitro
    Autorzy:
    Ignacak, Jan
    Wiśniewska-Wrona, Maria
    Pałka, Iwona
    Zagajewski, Jacek
    Niekraszewicz, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1035427.pdf
    Data publikacji:
    2011
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    EAT cells proliferation
    L-S-nitrosocysteine.
    chitosan oligomers
    pyruvate kinase M2 isoenzyme
    Opis:
    Preliminary studies of proliferation of Ehrlich ascites tumor (EAT) cells and normal mammary gland epithelial cells have demonstrated the process to be inhibited by degradation products of microcrystalline chitosan, i.e. oligomers. Inhibition of proliferation has been also accompanied by a decreased activity of the M2 pyruvate kinase (PK) isoenzyme in nucleoplasm, what may indicate the role of this enzyme in regulation of tumor cell proliferation. Determinations of nitrogen oxide in tumor and normal cells point to a higher level of this endogenous effector in normal cells. An increase of nitrogen oxide levels in Ehrlich ascites tumor cells effected by chitosan oligomers may indicate increased nitrosylation, and particularly an increased amount of compounds containing sulfhydryl groups and their participation in regulation of nucleoplasm M2 PK isoenzyme activity. Chitosan oligomers have smaller molecules as compared to microcrystalline chitosan and for this reason appear to be more effective than the latter in acting upon the negatively charged cell membrane surfaces, thus contributing to proliferation inhibition.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2011, 16; 89-98
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Tromboguard® - first aid wound dressing
    Autorzy:
    Kucharska, Magdalena Kucharska
    Struszczyk, Marcin H.
    Niekraszewicz, Antoni
    Ciechańska, Danuta
    Witczak, Elżbieta
    Tarkowska, Sylwia
    Fortuniak, Krystyna
    Gulbas-Diaz, Anna
    Rogaczewska, Agnieszka
    Płoszaj, Ilona
    Pluta, Aleksandra
    Gąsiorowski, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035453.pdf
    Data publikacji:
    2011
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    medical devices.
    microcrystalline chitosan sponges
    preclinical studies
    wound dressings
    Opis:
    Recently, the market of medical devices shows serious need for wound dressings for first aid and temporary traumatic wounds. Such a wound dressing should show primarily the hemostatic effect and antibacterial activity allowing protection against infection. Tromboguard® topical wound dressing is a three-layer dressing with active layer. It contains chitosan, sodium alginate/calcium alginate with addition of silver salt. The wound dressing provides protective performance as well as is characterized by the ability to immediately stop bleeding and antibacterial activity allowing protection against infection and occurrence of secondary infection without the need for or with limited participation of antibiotics. Tromboguard® topical wound dressing is a firs aid dressing designed for the uniform services (military and homeland) and rescue.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2011, 16; 121-130
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biopolymer compositions for ecological protection and growth stimulation of plants
    Autorzy:
    Niekraszewicz, Antoni
    Wiśniewska-Wrona, Maria
    Kopania, Ewa
    Orlikowski, Leszek
    Pospieszny, Henryk
    Krawczyk, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1035390.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    biopolymer compositions
    growth stimulation.
    plant protection
    polysaccharides
    Opis:
    Presented herein are investigations in the preparation of an advanced , human-and environmentfriendly plant protection composition based on selected bioactive biopolymers of the polysaccharide family. In the Institute of Biopolymers and Chemical Fibres the biopolymers were prepared and the biological activity of chitosan in the form of salt and gel and of hemicelluloses (galactoglucomannans) and of their compositions was tentatively evaluated by way of plate tests. Estimated was the impact of such preparations upon the stimulation of the germination rate of radish seeds at concentration of 0.1, 0.01 and 0.005% after 72 hours. The efficacy of the preparations was evaluated based on the number of germinated seeds in the green mass of the sprouts and their length in comparison to a reference in water at pH = 7.0. In Research Institute of Horticulture, Skierniewice, Poland the usefulness of selected iopolymer preparations was evaluated as agents to protect decorative plants against some pathogens (on leaves, in soil) such as Phytophtora cryptogea causing decay of shoots and roots. It could be found that the biopolymer compositions applied to the soil provided a much better rooting of chrysanthemum cuttings in a Phytophtora cryptogea - infected soil. The cuttings were growing much faster and the number of infected ones was largely reduced. The usefulness of a number of chitosan formulations was also evaluated for seed pickling. It was found that the formulations exerted a distinctly positive impact upon the germination, growth and health of the seedlings. Laboratory and greenhouse testing was made in the Institute of Plant Protection, Poznań, Poland where the biological activity of some biopolymer compositions was evaluated. A first selection of the biopolymers was done based on an in vitro examination of the impact upon bacteria growth. (Gram negative - Erwinia amylovora and Gram positive Clavibacter ichiganensis ) on agar or agarose plates and upon the generation of necrotic stains on beans and tobacco caused by lucerne mosaic virus and tobacco mosaic virus respectively. It was found that the preparations with original biopolymer concentration had not affected the viruses directly but stimulated the plants’ immunity against the pathogens.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 149-162
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of oligochitosans on expression of inos gene in ehrlich ascites tumour in vitro
    Autorzy:
    Ignacak, Jan
    Wiśniewska-Wrona, Maria
    Dulińska-Litewka, Joanna
    Pałka, Iwona
    Zagajewski, Jacek
    Niekraszewicz, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1035407.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan oligomers
    histone H1
    iNOS (inducible nitric oxide synthase)
    nitric oxide
    Opis:
    Oligochitosans obtained through degradation of macromolecules of chitosan with a high degree of deacetylation turned out to be biologically active, contributing to an increase of nitric oxide levels in Ehrlich ascites tumor (EAT) cells through inducing expression of the isoform of inducible nitric oxide synthase (iNOS) gene. An increase of NO levels in EAT cells in the presence of the investigated oligochitosans might contribute to nitrosylation of L-cysteine – an allosteric effector of the M2 isoenzyme of pyruvate kinase (PK), which switches the PK kinase activity, responsible for ATP synthesis, to the histone kinase activity that may participate in histone H1 phosphorylation. Lack of the histone activity of the PK M2 isoenzyme may contribute to decreased histone H1 phosphorylation and thus inhibit EAT cells proliferation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 141-148
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of oligochitosans in regulation of cellular activity and location of pyruvate kinase (pk) isoenzyme m2 that affects proliferation of ehrlich ascites tumor cells (eat)
    Autorzy:
    Ignacak, Jan
    Wiśniewska-Wrona, Maria
    Pałka, Iwona
    Niekraszewicz, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1035231.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    isoenzyme M1 and M2 pyruvate kinase
    nucleus
    oligochitosans
    ε-methyl-L-lysyne
    Opis:
    The pyruvate kinase isoenzyme M2 originating from the nucleoplasm and cytoplasm of tumor cells, with its highest affinity to the 2-phosphoenolpyruvate (2-PEP) and sensitivity to L-cysteine, contributes to an increased generation of energy as ATP, necessary for tumor cell proliferation. In the presence of L-cysteine, the isoenzyme M2 PK demonstrates the activity of histone kinase, transferring the phosphoryl group from 2-PEP to the ε-amine residue of the H1 histone lysine. Oligochitosans induce expression of the inducible nitric oxide synthase gene (iNOS), what results in an increased synthesis of nitric oxide, which reacts with L-cysteine and produces L-S-nitrosocysteine. Lack of L-cysteine contributes to inhibition of kinase activity of the H1 histone, an M2 PK isoenzyme. Decreased phosphorylation of the H1 histone contributes to inhibition of EAT cell proliferation. No effect on proliferation of normal cells that include the PK M1 isoenzyme has been observed in the presence of oligochitosans.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 67-76
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of oligochitosans in regulation of cellular activity and location of pyruvate kinase (pk) isoenzyme m2 that affects proliferation of ehrlich ascites tumor cells (eat)
    Autorzy:
    Ignacak, Jan
    Wiśniewska-Wrona, Maria
    Pałka, Iwona
    Niekraszewicz, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1035209.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    isoenzyme M1 and M2 pyruvate kinase
    nucleus
    oligochitosans
    ε-methyl-L-lysyne
    Opis:
    The pyruvate kinase isoenzyme M2 originating from the nucleoplasm and cytoplasm of tumor cells, with its highest affinity to the 2-phosphoenolpyruvate (2-PEP) and sensitivity to L-cysteine, contributes to an increased generation of energy as ATP, necessary for tumor cell proliferation. In the presence of L-cysteine, the isoenzyme M2 PK demonstrates the activity of histone kinase, transferring the phosphoryl group from 2-PEP to the ε-amine residue of the H1 histone lysine. Oligochitosans induce expression of the inducible nitric oxide synthase gene (iNOS), what results in an increased synthesis of nitric oxide, which reacts with L-cysteine and produces L-S-nitrosocysteine. Lack of L-cysteine contributes to inhibition of kinase activity of the H1 histone, an M2 PK isoenzyme. Decreased phosphorylation of the H1 histone contributes to inhibition of EAT cell proliferation. No effect on proliferation of normal cells that include the PK M1 isoenzyme has been observed in the presence of oligochitosans.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 67-76
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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