Utilization of biodegradable polymers for peripheral nerve reconstruction

Peripheral nerve injuries are one of frequent cause of disability. Results of surgical procedures are not still completely satisfactory, though fast development of microsurgical technician improve their efficiency. One of the major problems in surgical treatment of the peripheral nerve injuries is ends coaptation in the case of large loss of nerve tissue. And so finding substitute implants not rejected by the organism for the recipient and providing with the success is necessary of regeneration. Recently, several synthetic nerve guide implants have been introduced and approved for clinical use to replace autologous transplants. This alternative therapy is based on pioneering studies with experimental nerve guides. This paper present a review of published studies involving biodegradable nerve guides.