Autor: Motyl, T. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Uwalnianie amoniaku z białka przyczyną zawyżania wyników oznaczeń mocznika we krwi metodą Conwaya
Liberation of protein ammonia as a cause of elevated results of blood urea assays by the conway method
Autorzy:: Motyl, T.
Powiązania:: https://bibliotekanauki.pl/articles/2189252.pdf
Data publikacji:: 1975
Wydawca:: Polskie Towarzystwo Diagnostyki Laboratoryjnej
Źródło:: Diagnostyka Laboratoryjna; 1975, 11, 4; 319-325
0867-4043
Pojawia się w:: Diagnostyka Laboratoryjna
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The transcriptomic signature of myostatin inhibitory influence on the differentiation of mouse C2C12 myoblasts
Autorzy:: Wicik, Z.
Sadkowski, T.
Jank, M.
Motyl, T.
Powiązania:: https://bibliotekanauki.pl/articles/30247.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: GDF8 (myostatin) is a unique cytokine strongly affecting the skeletal muscle phenotype in human and animals. The aim of the present study was to elucidate the molecular mechanism of myostatin influence on the differentiation of mouse C2C12 myoblasts, using the global-transcriptome analysis with the DNA microarray technique. Treatment with exogenous GDF8 strongly affected the growth and development of C2C12 mouse myoblasts. This was manifested by the inhibition of proliferation and differentiation as well as the impairment of cell fusion. DNA microarray analysis revealed 778 genes regulated by GDF8 in differentiating myoblasts (436 down-regulated and 235 up-regulated). Ontological analysis revealed their involvement in 17 types of biological processes, 10 types of molecular functions and 68 different signalling pathways. The effect of GDF8 was mainly mediated by the disruption of the cell cycle, calcium and insulin signalling pathways and expression of cytoskeletal and muscle specific proteins. The identified key-genes that could play a role as GDF8 targets in differentiating myoblasts are: Mef2, Hgf, Ilb1, Itgb1, Edn1, Ppargc1a.
Źródło:: Polish Journal of Veterinary Sciences; 2011, 14, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Transcriptional pattern of TGF-beta1 inhibitory effect on mouse C2C12 myoblasts differentiation
Autorzy:: Wicik, Z.
Sadkowski, T.
Jank, M.
Motyl, T.
Powiązania:: https://bibliotekanauki.pl/articles/30377.pdf
Data publikacji:: 2010
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: transforming growth factor-beta 1
myogenesis
microarray
DNA microarray
differentiation
myoblast
mouse
mice
muscle cell
myosin heavy chain
Opis:: The aim of the present study was to define the effect of TGF-β1 on C2C12 myoblasts myogenesis. TGF-β1 together with its receptor is a negative auto-paracrine regulator of myogenesis, which influences the proliferation, differentiation, and functions of muscle cells. TGF-β1 exerts highly significant inhibitory effect on differentiation of C2C12 mouse myoblasts manifested by the impairment of cell fusion and very low expression of myosin heavy chain. The study of differentiating C2C12 mouse myoblasts treated with TGF-β1 revealed 502 genes (436 down-regulated and 66 up-regulated) with statistically different expression. TGF-β1-regulated genes were identified to be involved in 29 biological processes, 29 molecular functions groups and 59 pathways. The strongest inhibiting effect of TGF-β1 was observed in the cadherin and Wnt pathways. The key-genes that could play the role of TGF-β1 targets during myoblasts differentiation was identified such as: Max, Creb1, Ccna2, Bax, MdfI, Tef, Tubg1, Cxcl5, Rho, Calca and Lgals4.
Źródło:: Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Nowotwory gruczołu sutkowego u suk - model badań raka piersi u kobiet
Canine mammary tumors - a model for studying breast cancer in women
Autorzy:: Dolka, I.
Motyl, T.
Malicka, E.
Sapierzynski, R.
Powiązania:: https://bibliotekanauki.pl/articles/859178.pdf
Data publikacji:: 2010
Wydawca:: Krajowa Izba Lekarsko-Weterynaryjna
Tematy:: onkologia
psy
suki
nowotwory gruczolu sutkowego
czlowiek
nowotwory piersi
modele zwierzece
czynniki prognostyczne
markery nowotworowe
markery immunohistochemiczne
Źródło:: Życie Weterynaryjne; 2010, 85, 12
0137-6810
Pojawia się w:: Życie Weterynaryjne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Role of extracellular matrix and prolactin in functional differentiation of bovine BME-UV1 mammary epithelial cells
Autorzy:: Kozlowski, M.
Wilczak, J.
Motyl, T.
Gajewska, M.
Powiązania:: https://bibliotekanauki.pl/articles/31562.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Interactions between extracellular matrix (ECM) and epithelial cells are necessary for proper organisation and function of the epithelium. In the present study we show that bovine mammary epithelial cell line BME-UV1 cultured on ECM components, commercially available as Matrigel™, constitutes a good model for studying mechanisms controlling functional differentiation of the bovine mammary gland. In contact with Matrigel BME-UV1 cells induce apicobasal polarity, and within 16 days form three dimensional (3D) acinar structures with a centrally localized hollow lumen, which structurally resemble mammary alveoli present in the functionally active mammary gland. We have shown that the 3D culture system enables a high expression and proper localisation of integrin receptors and tight junction proteins in BME-UV1 cells to be induced. This effect was not obtained in cells grown in the classical 2D culture system on plastic. Moreover, ECM highly stimulated the synthesis of one of the major milk proteins, β-casein, even in the absence of prolactin. Our results show that contact with ECM plays an important role in the lactogenic activity of bovine MECs, however, prolactin is necessary for the efficient secretion of milk proteins.
Źródło:: Polish Journal of Veterinary Sciences; 2011, 14, 3
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Bone marrow-origin stem/progenitor cells in the mammary gland of heifers
Autorzy:: Osinska, E.
Godlewski, M.M.
Wierzbicki, M.
Motyl, T.
Powiązania:: https://bibliotekanauki.pl/articles/30416.pdf
Data publikacji:: 2014
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: The aim of the study was to estimate the size of bone marrow-origin stem/progenitor population in 2-year old nonpregnant Holstein-Friesian heifers. Quantitative and qualitative analysis was done using scanning cytometry and confocal microscopy of mammary tissue slices labelled with the combination of two markers: Sca-1 (marker of stem-progenitor cells) and CD45 (marker of hematopoietic cells). The average (±SEM) percentage of Sca-1POS CD45POS cells was 0.89 ± 0.21. They were localized mainly outside of mammary ducts, in the stroma and sometimes intraluminally. Our results indicate that the subpopulation of Sca-1POS cells bearing CD45 antigen may enrich the niche of mammary stem/progenitor cells from the bone marrow and participate in the growth of the mammary gland in post-pubertal heifers.
Źródło:: Polish Journal of Veterinary Sciences; 2014, 17, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: DNA microarrays - future in oncology research and therapy
Autorzy:: Krol, M.
Pawlowski, K.M.
Otrebska, D.
Motyl, T.
Powiązania:: https://bibliotekanauki.pl/articles/3349.pdf
Data publikacji:: 2008
Wydawca:: Instytut Medycyny Wsi
Tematy:: DNA microarray
future
oncology
research
therapy
genomics
gene expression
canine mammary cancer
tumour
human disease
cancer
Źródło:: Journal of Pre-Clinical and Clinical Research; 2008, 02, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Relationship between receptors for insulin-like growth factor - I, steroid hormones and apoptosis-associated proteins in canine mammary tumors
Autorzy:: Dolka, I.
Motyl, T.
Malicka, E.
Sapierzynski, R.
Fabisiak, M.
Powiązania:: https://bibliotekanauki.pl/articles/32455.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: relationship
receptor
insulin-like growth factor
steroid hormone
apoptosis-associated protein
dog
mammary tumour
cancer
Opis:: In the veterinary literature there are few data concerning the expression of insulin-like growth factor type I (IGF-IR) in the canine mammary gland tumors. The aim of the present study was the evaluation of IGF-IR expression and its correlation to the expression of estrogen receptor α (ERα) and progesterone receptor (PR), proteins: Bcl-2, Bax, p53 in canine mammary gland tumors, and also a correlation with other features: bitch’s age, tumor diameter, histologic type of tumor, degree of histologic malignancy, proliferate activity. The study was done on 112 epithelial neoplasms: 21 (19%) were adenoma, 38 (34%) complex carcinoma (adenocarcinoma), 47 (42%) simple carcinoma (adenocarcinoma) and 6 (5%) solid carcinoma. Histochemistry and immunohistochemistry methods were employed. It was shown that more common and/or higher IGF-IR expression in cells of canine mammary gland tumors was related to the histologic type of cancer of worse prognostic (solid and simple carcinoma), high histologic degree of malignancy (IIIo) but the statistical analysis did not reveal any significant differences. We observed the high degree of IGF-IR expression in tumors which displayed the high ERα and PR expression. These results suggest the involvement of IGF-IR in the development of hormonosensitive canine mammary tumors. Additionally, the significant positive correlation between expression of IGF-IR and p53, Bax was found. Our study provides some evidence that interactions exist between the IGF-IR and these apoptosis-associated proteins may contribute to the development and progression of canine mammary gland tumors. These results require further investigations.
Źródło:: Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: A role of ghrelin in cancerogenesis
Autorzy:: Majchrzak, K.
Szyszko, K.
Pawlowski, K.M.
Motyl, T.
Krol, M.
Powiązania:: https://bibliotekanauki.pl/articles/31726.pdf
Data publikacji:: 2012
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: ghrelin
cancerogenesis
growth hormone secretagogue receptor
cancer
mammary cancer
veterinary oncology
oncology
dog
animal disease
Opis:: Ghrelin is a 28 amino-acid multi-functional peptide hormone, which was identified as a natural ligand of the growth hormone secretagogue receptor (GHS-R). Pituitary growth hormone-releasing activity in both animals and humans has been well documented. It has various biological functions, including regulation of appetite and body weight, control of energy homeostasis, modulation of cardiovascular and gastrointestinal system and anti-inflammatory effect. However, both ghrelin and its receptor (GHS-R) are widely distributed in various tumors, which strongly implies their role in neoplastic cell growth trough autocrine/paracrine mechanism. Multiple studies have demonstrated the role of ghrelin in cancer cells proliferation, differentiation, invasiveness and apoptosis inhibition. The ghrelin axis is more complex than it was originally thought and consist of several compounds that might interact with each other and affect ghrelin activities. Here, we provide an overview of the ghrelin and its receptor role in tumor progression.
Źródło:: Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Canine mammary carcinoma cell line are resistant to chemosensitizers: verapamil and cyclosporin A
Autorzy:: Krol, M.
Pawlowski, K.M.
Majchrzak, K.
Mucha, J.
Motyl, T.
Powiązania:: https://bibliotekanauki.pl/articles/32199.pdf
Data publikacji:: 2014
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Cancer chemotherapy can fail in many ways. One of the most significant is the development of multiple drug resistance (MDR), which constitutes a serious clinical problem. The development of MDR relates to the expression of a major membrane pump, P-glycoprotein (P-gp). Thus, currently one of the goals of experimental and clinical oncology is to decrease its activity. So far, many different P-gp inhibitors are available, but their efficacy is still questionable and requires further study. The aim of our study was to assess an impact of classical P-gp inhibitors (verapamil and cyclosporin A) in the reversion of multidrug resistance in canine mammary cancer cells. We used two cell lines isolated from mammary tumors and two cell lines isolated from their lung metastases. All of them showed P-gp over-expression confirmed using Real-time rt-PCR, Skan^R screening station and confocal microscopy. The FACS analysis showed that in three of the examined cell lines, treatment with verpamil/cyclosporin A was ineffective to reverse cancer chemoresistance. However, more studies in this field are required.
Źródło:: Polish Journal of Veterinary Sciences; 2014, 17, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Pressure agglomeration of biomass with additive of rapeseed oil cake or calcium carbonate
Aglomeracja ciśnieniowa biomasy z dodatkiem makuchów rzepakowych lub węglanu wapnia
Autorzy:: Lisowski, A.
Dabrowska-Salwin, M.
Swietochowski, A.
Motyl, T.
Pajewski, M.
Powiązania:: https://bibliotekanauki.pl/articles/793697.pdf
Data publikacji:: 2013
Wydawca:: Komisja Motoryzacji i Energetyki Rolnictwa
Tematy:: pressure agglomeration
pellet
calcium carbonate
rapeseed oil
rapeseed oil cake
mechanical durability
biomass
Źródło:: Teka Komisji Motoryzacji i Energetyki Rolnictwa; 2013, 13, 1
1641-7739
Pojawia się w:: Teka Komisji Motoryzacji i Energetyki Rolnictwa
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Gene expression pattern in canine mammary osteosarcoma
Autorzy:: Pawlowski, K.
Majewska, A.
Szyszko, K.
Dolka, I.
Motyl, T.
Krol, M.
Powiązania:: https://bibliotekanauki.pl/articles/32248.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: bone tumour
canine mammary osteosarcoma
gene expression
mammary osteosarcoma
microarray
osteosarcoma
transcriptome
tumour
sarcoma
proliferation
aggressive tumour
gene list
Opis:: Canine mammary sarcomas are usually very aggressive and easily metastasize. Unfortunately the biology of this type of tumor is not well known because they are a very rare type of tumors. The aim of this study was to find differences in gene expression patterns in canine mammary osteosarcomas (malignant) versus osteomas (benign) using DNA microarrays. Our microarray experiment showed that 11 genes were up-regulated in osteosarcoma in comparison to osteoma whereas 36 genes were down-regulated. Among the up-regulated genes were: PDK1, EXT1, and EIF4H which are involved in AKT/PI3K and GLI/Hedgehog pathways. These genes play an important role in cell biology (cancer cell proliferation) and may be essential in osteosarcoma formation and development. Analyzing the down-regulated genes, the most interesting seemed to be HSPB8 and SEPP1. HSPB8 is a small heat shock protein that plays an important role in cell cycle regulation, apoptosis, and breast carcinogenesis. Also SEPP1 may play a role in carcinogenesis, as its down-regulation may induce oxidative stress possibly resulting in carcinogenesis. The preliminary results of the present study indicate that the up-regulation of three genes EXT1, EIF4H, and PDK1 may play an essential role in osteosarcoma formation, development and proliferation. In our opinion the cross-talk between GLI/Hedgehog and PI3K/AKT pathways may be a key factor to increase tumor proliferation and malignancy.
Źródło:: Polish Journal of Veterinary Sciences; 2011, 14, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Density of tumor-associated macrophages (TAMs) and expression of their growth factor receptor MCSF-R and CD14 in canine mammary adenocarcinomas of various grade of malignancy and metastasis
Autorzy:: Krol, M.
Pawlowski, K.
Majchrzak, K.
Dolka, I.
Abramowicz, A.
Szyszko, K.
Motyl, T.
Powiązania:: https://bibliotekanauki.pl/articles/32107.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: adenocarcinoma
canine adenocarcinoma
density
dog
expression
growth factor
immunohistochemistry
immunology
malignancy
mammary adenocarcinoma
metastasis
tissue sample
tumour microenvironment
tumour-associated macrophage
Opis:: Several years ago, the presence of macrophages in the tumor microenvironment was thought to be an inflammatory response to kill the cancer cells. Now, this is clear that the inflammatory cells that exit blood vessels and migrate to the tumor tissue play an important role in cancer progression. Various cells present in the tumor microenvironment enhance cancer growth and invasiveness by secretion of tumor-enhancing products. That is why tumors should not be treated as only aggregates of cancer cells but as separate structures. Macrophages form a major component of the inflammatory infiltration in tumors, where they are termed tumor-associated macrophages (TAMs). To the best of our knowledge, up-to-date there were no studies on tumor associated macrophages and the role of the tumor microenvironment in tumor invasion/metastasis in dogs. This is the first study performed to asses if the number of TAMs and expression of MCSF-R (macrophages colony stimulating factor receptor) and CD14 (LPS co-receptor) are associated with the grade of tumor malignancy and its ability to metastasize. We have performed immunohistochemical analysis of 50 canine mammary adenocarcinomas of various grade of malignancy (1st, 2nd, 3rd) and tumors that gave local or distant metastases. The results indicate that in dogs, similarly to humans and mice, the number of tumor associated macrophages is related to the cancer ability to metastasize. Our results also indicate that the expression of MCSF-R and, what is particularly new finding, CD14 is associated with tumor malignancy and its ability to metastasize. Hence, these molecules play a role in tumor progression, metastasis and microenvironment interactions. These results show that in dogs we should treat the tumor as a whole organ rather than just try to eliminate the cancer cells.
Źródło:: Polish Journal of Veterinary Sciences; 2011, 14, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Mismatch between transcriptomic and histopathologic picture of canine lymphomas
Autorzy:: Ostrzeszewicz, M.
Maciejewski, H.
Sapierzynski, R.
Micun, J.
Majewska, A.
Lechowski, R.
Motyl, T.
Jank, M.
Powiązania:: https://bibliotekanauki.pl/articles/32128.pdf
Data publikacji:: 2012
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Lymphoma is one of the most common malignant tumours occurring in dogs. Since there is a constant need for new, more comprehensive laboratory diagnostic tools which permit the precise determination of many tumour-related factors we decided to verify whether the use of microarray analysis could be helpful in classifying lymphomas. The study was performed on samples collected from 7 dogs in which multicentric lymphoma was recognized. Among this group we were able to identify one sub-cluster of transcriptionally similar tumours, which completely differed in terms of the histopathological examination. Among them there were one diffuse large B cell lymphoma, one diffuse macronucleolated medium-sized cell lymphoma and one pleomorphic mixed small and large T-cell lymphoma. The lymphomas belonging to the sub-cluster differed from other analysed tumours in the expression of more than 100 genes of which only 18 were described earlier in regard to lymphomas.
Źródło:: Polish Journal of Veterinary Sciences; 2012, 15, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Koncepcja zautomatyzowanego systemu obrony przeciwlotniczej rozproszonej baterii lub dywizjonu armat 35 mm
The Idea of Automated Anti-aircraft Defense System of Distributed Battery or Squadron Equipped with 35 mm Canons
Autorzy:: Sienicki, K.
Motyl, K.
Zawada, T.
Powiązania:: https://bibliotekanauki.pl/articles/403614.pdf
Data publikacji:: 2012
Wydawca:: Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
Tematy:: obrona przeciwlotnicza
zautomatyzowany system kierowania ogniem
modelowanie i symulacja komputerowa
anti-aircraft defense
automated fire control system
modeling and computer simulation
Opis:: W artykule przedstawiono koncepcję zautomatyzowanego systemu obrony przeciwlotniczej rozproszonej baterii lub dywizjonu armat 35 mm realizowaną w ramach projektu rozwojowego na lata 2009-2011. Efektem końcowym realizacji projektu będzie demonstrator technologii umożliwiający badania symulacyjne zautomatyzowanego systemu obrony przeciwlotniczej, który wykorzystuje elementy wykrywania celów, podziału zadań, śledzenia celów i kierowania ogniem armat 35 mm z wykorzystaniem amunicji programowalnej i klasycznej. Na podstawie badań symulacyjnych powstanie koncepcja takiego systemu obrony przeciwlotniczej krótkiego zasięgu.
In this article the idea of automated anti-aircraft defense system was presented. The system consists of distributed battery or squadron of 35 mm canons and is realizing as development project in 2009-2011 years. The project realization final effect will be technology demonstrator which enables computer simulation research of automated antiaircraft defense systems which uses components of: target detection, task distribution, target tracking and fire control of 35 mm canons with usage of programmable and classical ammunition. Based on computer simulation research the conception (project) of such a short range anti-aircraft defense system will be created.
Źródło:: Problemy Mechatroniki : uzbrojenie, lotnictwo, inżynieria bezpieczeństwa; 2012, 3, 4 (10); 99-112
2081-5891
Pojawia się w:: Problemy Mechatroniki : uzbrojenie, lotnictwo, inżynieria bezpieczeństwa
Dostawca treści:: Biblioteka Nauki

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