In the veterinary literature there are few data concerning the expression of insulin-like growth
factor type I (IGF-IR) in the canine mammary gland tumors. The aim of the present study was the
evaluation of IGF-IR expression and its correlation to the expression of estrogen receptor α (ERα)
and progesterone receptor (PR), proteins: Bcl-2, Bax, p53 in canine mammary gland tumors, and also
a correlation with other features: bitch’s age, tumor diameter, histologic type of tumor, degree of
histologic malignancy, proliferate activity. The study was done on 112 epithelial neoplasms: 21 (19%)
were adenoma, 38 (34%) complex carcinoma (adenocarcinoma), 47 (42%) simple carcinoma (adenocarcinoma)
and 6 (5%) solid carcinoma. Histochemistry and immunohistochemistry methods were
employed. It was shown that more common and/or higher IGF-IR expression in cells of canine
mammary gland tumors was related to the histologic type of cancer of worse prognostic (solid and
simple carcinoma), high histologic degree of malignancy (IIIo) but the statistical analysis did not
reveal any significant differences. We observed the high degree of IGF-IR expression in tumors which
displayed the high ERα and PR expression. These results suggest the involvement of IGF-IR in the
development of hormonosensitive canine mammary tumors. Additionally, the significant positive
correlation between expression of IGF-IR and p53, Bax was found. Our study provides some evidence
that interactions exist between the IGF-IR and these apoptosis-associated proteins may contribute to
the development and progression of canine mammary gland tumors. These results require further
investigations.
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