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    Wyświetlanie 1-7 z 7
    Tytuł:
    Życie społeczno-religijne Olsztynka w latach 1945–1950
    Social and religious life in Olsztynek in the years 1945–1950
    Autorzy:
    Makowski, Jakub
    Powiązania:
    https://bibliotekanauki.pl/articles/2147305.pdf
    Data publikacji:
    2020-12
    Wydawca:
    Wyższe Seminarium Duchowne Diecezji Elbląskiej w Elblągu
    Tematy:
    Olsztynek (Hohenstein)
    Armia Czerwona
    Prusy Wschodnie
    Polska Rzeczpospolita Ludowa
    przesiedlenia ludności
    repatrianci
    Mazurzy
    Kościół katolicki
    Kościół ewangelicki
    Olsztynek
    Hohenstein
    Red Army
    East Prussia
    Polish Peoples Republic
    resettlement
    repatriation
    Masurians
    Catholic Church
    Evangelical Church
    Opis:
    Artykuł opowiada o wydarzeniach, do których doszło po włączeniu Olsztynka do Polski Ludowej po zakończeniu II wojny światowej. Tekst skupia się przede wszystkim na opisie przemian społeczno-religijnych, które były efektem całkowitej zmiany struktury ludności oraz wprowadzenia władz komunistycznych na poniemieckich terenach. Podstawę źródłową stanowią materiały znajdujące się w Archiwum Państwowym w Olsztynie oraz Archiwum Archidiecezji Warmińskiej, kroniki, relacje świadków oraz opracowania polsko- i niemieckojęzyczne. Tekst dowodzi, jak powojenne realia nieodwracalnie zmieniły charakter miasta. Stanowi wnikliwe usystematyzowanie informacji o tym krótkim, lecz przełomowym okresie w dziejach Olsztynka.
    In the article, the author explains the course of events after incorporating Olsztynek into the Polish People’s Republic after the Second World War. Makowski’s main areas of focus are the changes observed in religious and social spheres as well as the implementation of a new, communist government in lands previously inhabited by Germans. The author’s sources are the National Archive in Olsztyn, the Warmia Archdiocese Archive along with chronicles, witness accounts, and studies in both Polish and German. Makowski points out the changes that took place in Olsztynek after the Second World War. The article providesa clear and deep analysis of this short yet critical event in the history of Olsztynek.
    Źródło:
    Studia Elbląskie; 2020, 21; 179-195
    1507-9058
    Pojawia się w:
    Studia Elbląskie
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ wiązań wodorowych na kwasowość związków chemicznych
    The influence of hydrogen bonding on the acidity of chemical compounds
    Autorzy:
    Brzeski, Jakub
    Makowski, Mariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/972277.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    wiązanie wodorowe
    kwasowość
    skala kwasowości
    hydrogen bonding
    acidity
    acidity scale
    Opis:
    Both intra- and intermolecular hydrogen bonds increase the acidity of the systems in which they occur. Stabilization of the anion formed after deprotonation with a single intramolecular hydrogen bond causes a significant increase in the strength of acid in question, compared to the system in which such interaction does not exist. Hydrogen bonds, through their influence on the acid-base properties of chemical compounds, play a key role in organic chemistry, coordination chemistry, biochemistry and medicine. This paper comprise a review of the most important publications on the impact of hydrogen bonds on the acidity of chemical compounds and the relationship between the specificity of hydrogen bonds and the strength of the resulting acid. The relationship between intermolecular hydrogen bond energy and the pKa value of a given complex is thoroughly discussed in this paper. It turns out that the energy of the hydrogen bond is not related to a single value of pKa of neither the donor nor acceptor of this bond, but rather to the relative difference of these quantities. Namely, the strongest bonds are formed between those systems for which the pKa’s of a donor and acid conjugated to an acceptor differ the least. The feature that clearly correlates with the pKa value of the acid turns out to be the hydrogen bond length. The results of crystallographic studies have shown that the pKa values of C-H acids strongly correlate with the length of C-H ••• O hydrogen bonds. It is worth noting here that the correlation is much better for systems in which the formation of a hydrogen bond is not sterically hindered. In the abundance of donor and acceptor groups in the structure of an acid and its corresponding base, the anion formed after deprotonation is stabilized by phenomenon known as networking. Spreading the negative charge over a larger area of the molecule increases the stability of the anion and thus significantly increases the strength of the corresponding acid. Acids, whose acidity is mainly based on the networking are called SHEAs (single-centered hydrogen-bonded enhanced acidity acids). In addition, the effect of hydrogen bonds on the acidity of specific biochemical systems, namely nucleobases, has been discussed based on the papers by Wetmore and collaborators. It turns out that intra- and extracellular water molecules should not be overlooked when assessing the acidity of biomolecules.
    Źródło:
    Wiadomości Chemiczne; 2020, 74, 9-10; 629-644
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modelling particle deagglomeration in a batch homogenizer using full CFD and mechanistic models
    Autorzy:
    Krzosa, Radosław
    Wojtas, Krzysztof
    Golec, Jakub
    Makowski, Łukasz
    Orciuch, Wojciech
    Adamek, Radosław
    Powiązania:
    https://bibliotekanauki.pl/articles/2034041.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    population balance
    titanium dioxide
    CFD
    breakup
    high shear impeller
    bilans populacji
    dwutlenek tytanu
    wirnik o wysokim ścinaniu
    Opis:
    Modelling of titanium dioxide deagglomeration in the mixing tank equipped with a high shear impeller is presented in this study. A combination of computational fluid dynamics with population balance was applied for prediction of the final particle size. Two approaches are presented to solve population balance equations. In the first one, a complete population balance breakage kinetics were implemented in the CFD code to simulate size changes in every numerical cell in the computational domain. The second approach uses flow field and properties of turbulence to construct a mechanistic model of suspension flow in the system. Such approach can be considered as an attractive alternative to CFD simulations, because it allows to greatly reduce time required to obtain the results, i.e., the final particle size distribution of the product. Based on experiments shattering breakage mechanism was identified. A comparison of the mechanistic model and full CFD does not deviate from each other. Therefore the application of a much faster mechanistic model has comparable accuracy with full CFD. The model of particle deagglomeration does not predict a very fast initial drop of particle size, observed in the experiment, but it can predict, with acceptable accuracy, the final particle size of the product.
    Źródło:
    Chemical and Process Engineering; 2021, 42, 2; 105-118
    0208-6425
    2300-1925
    Pojawia się w:
    Chemical and Process Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Direct tumor damage mechanisms of photodynamic therapy.
    Autorzy:
    Nowis, Dominika
    Makowski, Marcin
    Stokłosa, Tomasz
    Legat, Magdalena
    Issat, Tadeusz
    Gołąb, Jakub
    Powiązania:
    https://bibliotekanauki.pl/articles/1041411.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    photosensitizer
    tumor
    photodynamic therapy
    apoptosis
    Opis:
    Photodynamic therapy (PDT) is a clinically approved and rapidly developing cancer treatment regimen. It is a minimally invasive two-stage procedure that requires administration of a photosensitizing agent followed by illumination of the tumor with visible light usually generated by laser sources. A third component of PDT is molecular oxygen which is required for the most effective antitumor effects. In the presence of the latter, light of an appropriate wavelength excites the photosensitizer thereby producing cytotoxic intermediates that damage cellular structures. PDT has been approved in many countries for the treatment of lung, esophageal, bladder, skin and head and neck cancers. The antitumor effects of this treatment result from the combination of direct tumor cell photodamage, destruction of tumor vasculature and activation of an immune response. The mechanisms of the direct photodamage of tumor cells, the signaling pathways that lead to apoptosis or survival of sublethaly damaged cells, and potential novel strategies of improving the antitumor efficacy of PDT are discussed.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 339-352
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pioglitazone, a PPAR-gamma ligand, exerts cytostatic/cytotoxic effects against cancer cells, that do not result from inhibition of proteasome
    Autorzy:
    Mrówka, Piotr
    Głodkowska, Eliza
    Młynarczuk-Biały, Izabela
    Biały, Łukasz
    Kuckelkorn, Ulrike
    Nowis, Dominika
    Makowski, Marcin
    Legat, Magdalena
    Gołąb, Jakub
    Powiązania:
    https://bibliotekanauki.pl/articles/1040817.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    peroxisome proliferator-activated receptor-gamma
    thiazolidinediones
    proteasome
    pioglitazone
    Opis:
    Thiazolidinediones are oral antidiabetic agents that activate peroxisome proliferator-activated receptor-gamma (PPAR-γ) and exert potent antioxidant and anti-inflammatory properties. It has also been shown that PPAR-γ agonists induce G0/G1 arrest and apoptosis of malignant cells. Some of these effects have been suggested to result from inhibition of proteasome activity in target cells. The aim of our studies was to critically evaluate the cytostatic/cytotoxic effects of one of thiazolidinediones (pioglitazone) and its influence on proteasome activity. Pioglitazone exerted dose-dependent cytostatic/cytotoxic effects in MIA PaCa-2 cells. Incubation of tumor cells with pioglitazone resulted in increased levels of p53 and p27 and decreased levels of cyclin D1. Accumulation of polyubiquitinated proteins within cells incubated with pioglitazone suggested dysfunction of proteasome activity. However, we did not observe any influence of pioglitazone on the activity of isolated proteasome and on the proteolytic activity in lysates of pioglitazone-treated MIA PaCa-2 cells. Further, treatment with pioglitazone did not cause an accumulation of fluorescent proteasome substrates in transfected HeLa cells expressing unstable GFP variants. Our results indicate that pioglitazone does not act as a direct or indirect proteasome inhibitor.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 1; 75-84
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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