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    Tytuł:
    Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers
    Autorzy:
    Wu, Fen
    Liu, Jing
    Qiu, Yu-Lan
    Wang, Wei
    Zhu, Shou-Min
    Sun, Pin
    Miao, Wen-Bin
    Li, Yong-Liang
    Brandt-Rauf, Paul W.
    Xia, Zhao-Lin
    Powiązania:
    https://bibliotekanauki.pl/articles/2179802.pdf
    Data publikacji:
    2013-03-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    vinyl chloride monomer
    chromosome damage
    MGMT
    hMLH1
    DNA methylation
    Opis:
    Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specifi c PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block micronucleus assay. The subjects were divided into chromosome damaged and non-damaged groups based on the normal reference value of micronuclei frequencies determined for two control groups. Results: MGMT promoter methylation was detectable in 5 out of 49 chromosome damaged subjects, but not in the chromosome non-damaged subjects; there was a signifi cant difference in MGMT methylation between the two groups (p < 0.05). Conclusions: We detected aberrant promoter methylation of MGMT in a small number of chromosome damaged VCM-exposed workers, but not in the chromosome non-damaged subjects. This preliminary observation warrants further investigation in a larger study.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2013, 26, 1; 173-182
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigation of the Dynamic Characteristics and Machining Stability of a Bi-rotary Milling Tool
    Autorzy:
    Hung, Jui-Pin
    Lin, Wei-Zhu
    Powiązania:
    https://bibliotekanauki.pl/articles/103262.pdf
    Data publikacji:
    2019
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    bi-rotary milling head
    dynamic characteristics
    five axis milling machine
    machining stability
    głowica frezarska dwuobrotowa
    właściwości dynamiczne
    frezarka pięcioosiowa
    stabilność obróbki
    Opis:
    Bi-rotary milling head is the primary component of multiple-axis machine tool toward the multiply machining operation. The machining performance is greatly related to the structure characteristics and positioning precisions of the swivel head. This study was aimed at developing a bi-rotary milling head module, which is composed of a direct drive motor, cross roller bearings and motorized spindle unit. In order to evaluate the machining stability at the design phase, the dynamic characteristics of the rotary milling were first analyzed with finite element method. Especially, the variations of the dynamic characteristics of the spindle tool with the changing of the titling configuration of swivel axis were examined. In order to consider the accurate presentation of a spindle tool system and swivel mechanism, the bearings in the rolling components were also included in the finite element model and simulated with surface contact elements with adequate contact stiffness. The dynamic frequency response function of the spindle tool at different swinging positions were predicted for comparisons, which were further used to calculate the machining stability based on the machining mechanics. The current results show that the feeding direction and swinging positions of rotary milling head have a significant influence on the dynamic characteristics and machining ability of the spindle tool. The variations of the cutting depth with the swinging of A axis fall in the range of 11% to 40%, depending on the feeding direction and swinging angle. The analysis results are expected to clearly demonstrate the variation of the machining performance of the spindle tool under different milling configurations. The devised model and modeling approach can be applied to develop a five axis milling machine with desired dynamic and machining performance.
    Źródło:
    Advances in Science and Technology. Research Journal; 2019, 13, 1; 14-22
    2299-8624
    Pojawia się w:
    Advances in Science and Technology. Research Journal
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research on communication emitter identification based on semi-supervised dimensionality reduction in complex electromagnetic environment
    Autorzy:
    Ge, Wei
    Qi, Lin
    Tong, Lin
    Zhu, Jun
    Zhang, Jing
    Zhao, Dongyang
    Li, Ke
    Powiązania:
    https://bibliotekanauki.pl/articles/27311449.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    communication emitter identification
    feature extraction
    dimensionality reduction
    VMD
    ESDA
    variational mode decomposition
    exponential semi-supervised discriminant analysis
    identyfikacja emitera komunikacyjnego
    ekstrakcja cech
    redukcja wymiarowości
    rozkład w trybie wariacyjnym
    analiza dyskryminacyjna wykładnicza półnadzorowana
    Opis:
    The individual identification of communication emitters is a process of identifying different emitters based on the radio frequency fingerprint features extracted from the received signals. Due to the inherent non-linearity of the emitter power amplifier, the fingerprints provide distinguishing features for emitter identification. In this study, approximate entropy is introduced into variational mode decomposition, whose features performed in each mode which is decomposed from the reconstructed signal are extracted while the local minimum removal method is used to filter out the noise mode to improve SNR. We proposed a semi-supervised dimensionality reduction method named exponential semi-supervised discriminant analysis in order to reduce the high-dimensional feature vectors of the signals, and LightGBM is applied to build a classifier for communication emitter identification. The experimental results show that the method performs better than the state-of-the-art individual communication emitter identification technology for the steady signal data set of radio stations with the same plant, batch and model.
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2023, 71, 4; art. no. e145766
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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