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Wyświetlanie 1-19 z 19
Tytuł:
Bioindykacyjne poszukiwania talu na terenach południowej Polski
Search for thallium in the areas of southern Poland by means of bioindication methods
Autorzy:
Dmowski, Krzysztof
Kozakiewicz, Anna
Kozakiewicz, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1201866.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Thallium is a highly toxic element. For this reason it was applied in production of rodenticides and insecticides for many years. At present, after a ban on Tl rat poisons, it is used only in small amounts. At the beginning of the article, is presented the toxic impact of thallium at the molecular level, its cumulation in particular plant and animal tissues as well as its influence on the condition of individuals and populations. In vertebrate tissues the element cumulates mostly in kidneys and livers and causes very severe neurological, gastrointestinal and cardiovascular disturbances. Despite its toxicity, thallium is an element very rarely studied in Poland and it is not under any routine monitoring. The research, carried out in the 1990-ties at the Department of Ecology, Warsaw University, in industrialised areas, allowed to point out several regions of the country which are seriously threatened by thallium, as well as to indicate direct sources of pollution. A two-step bioindication method was applied. Thallium concentrations were first measured in magpie feathers, and then in internal tissues of rodents. Polluted regions included mainly the surroundings of the zinc smelter 'Bolesław' in Bukowno near Olkusz and a non-ferrous metal smelter in Szopienice (district of Katowice). The thallium originated from post-floatation waste arising during Pb, Zn and Cd ore processing and stored in deposit reservoirs. The study of many plants, fungi, invertebrates and rodents carried out afterwards at the Department of Ecology in both these areas pointed to Tl tissue concentrations distinctly exceeding those that are typical for unpolluted samples, i.e. 0.00X-0.X mg/kg dry weight. In Bukowno the highest values were found: in kidneys of rodents - up to 34.27 mg/kg, in Arion slugs - up to 33.48, in ovaries of frogs - up to 51.61 mg/kg. In Szopienice the highest values were found in earthworms - up to 35.1 mg/kg, and in bush crickets Tettigonidae - up to 83.6 mg/kg. Inhabitants of the villages living in the vicinity of the reservoir in Bukowno can be threatened with Tl pollution for example due to direct consumption of vegetables that contained 1.28-3.70 mg/kg d.w. of thallium. The mentioned above regions, as well as areas near other ore smelters should be constantly monitored for thallium. This article proposes a range of preventive actions which would limit the influence of Tl pollution on humans and the environment.
Źródło:
Kosmos; 2002, 51, 2; 151-163
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of Impact of Gust Angle and Velocity on the Position of Stagnation Point
Autorzy:
Frant, Michał
Kozakiewicz, Adam
Kachel, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/102313.pdf
Data publikacji:
2020
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
inlet vortex
numerical fluid mechanics
turbine jet engine
wir wlotowy
numeryczna mechanika płynów
turbinowy silnik odrzutowy
Opis:
This paper presents the selected issues regarding the design of a complex object of a turbine jet engine inlet duct model for the purposes of numerical analysis related to the phenomenon of inlet vortex formation. The authors described the process of discretisation in the matter in question and presented certain guidelines for preparing and conducting discretisation of the computational area. The authors presented an exemplary test findings analysis to verify the accuracy of the object’s shape, computation grid as well as the selection of the boundary conditions and solution algorithm. The main part of the paper regards the analysis of changes in the location of the vortex (point of stagnation) based on an examination of the impact related to the changes in the velocity and inlet and gust angles. The authors sought to determine the areas and regularity of points of stagnation.
Źródło:
Advances in Science and Technology. Research Journal; 2020, 14, 4; 49-57
2299-8624
Pojawia się w:
Advances in Science and Technology. Research Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modeling studies of potato nucleoside triphosphate diphosphohydrolase NTPDase1: an insight into the catalytic mechanism
Autorzy:
Kozakiewicz, Anna
Neumann, Piotr
Banach, Mariusz
Komoszyński, Michał
Wojtczak, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1040830.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
potato apyrase
NTPDase1
enzymatic mechanism
homology modeling
Opis:
Nucleoside triphosphate diphosphohydrolase - NTPDase1 (apyrase, EC 3.6.1.5) was modeled based on sequence homology. The single polypeptide chain of apyrase is folded into two domains. The putative catalytic site with the apyrase conserved regions (ACR 1-5) is located between these two domains. Modeling confirmed that apyrase belongs to the actin superfamily of proteins. The amino acids interacting with the nucleoside triphosphate substrate and probably involved in the catalyzed hydrolysis were identified. The proposed two-step catalytic mechanism of hydrolysis involves Thr127 and Thr55 as potential nucleophilic factors responsible for the cleavage of the Pγ and Pβ anhydride bonds, respectively. Their action seems to be assisted by Glu170 and Glu78 residues, respectively. The presence of two nucleophiles in the active site of apyrase explains the differences in the hydrolytic activity between apyrases and other enzymes belonging to the NTPDase family.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 141-150
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of a 10-week step aerobics training on vo 2 max, isometric strength and body composition of young women
Autorzy:
Drobnik-Kozakiewicz, Izabela
Sawczyn, Michał
Zarębska, Aleksandra
Kwitniewska, Anna
Szumilewicz, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1054679.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
VO2 max
body composition
isometric strength
step aerobics
Opis:
Health status is partly determined by physical fitness level. Physical fitness can be developed through different physical activities under condition that regularity and intensity are maintained on optimal level. One of such physical activities is step aerobics - one of the most popular collective fitness forms offered in fitness clubs. The objective of this study was to evaluate the influence of step aerobics training on VO2max, isometric strength and body composition of young female students. Female students aged 19-21 of University of Physical Education and Sport in Gdańsk were subjects in this study. VO2max, isometric strength of elbow flexors and knee extensors, as well as body composition, were measured week before and week after a ten-week step aerobics training. For statistical analysis, basic descriptive statistics and student’s t-test were applied for dependent variables. After ten weeks of training there were no statistically significant changes in body composition, probably due to lack of calorie intake control. Significant changes were observed in isometric strength of elbow flexors but no changes in isometric strength of knee extensors. There was a compensation in isometric strength noted between left and right leg after ten weeks of training, where left leg was weaker than the right leg before training. Significant changes were noted in VO2max values, which increased from 42.04 ml/kg/min-1 to 45.71 ml/kg/min-1. Step aerobics training can sufficiently increase VO2max in young females and has a potential in developing strength of upper extremities. When body composition is the main purpose, diet should be taken under consideration.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2013, 4, 4; 3-9
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ELF3 as an important factor in carcinogenesis – a brief review of the recent studies
Autorzy:
Domańska, Julia
Poboży, Kamil
Kuryłek, Michał
Fudalej, Marta M.
Sobiborowicz, Aleksandra
Deptała, Andrzej
Badowska-Kozakiewicz, Anna M.
Powiązania:
https://bibliotekanauki.pl/articles/1035652.pdf
Data publikacji:
2020
Wydawca:
Medical Education
Tematy:
ELF3
carcinogenesis
molecular biology
Opis:
Introduction and objective: E74-like transcription factor 3 (ELF3) is mainly expressed in epithelial tissue, being responsible for differentiation and regeneration. Furthermore, it plays a role in inflammation, remodeling, allergy regulation and apoptosis. Various studies on ELF3 conducted since 1997 have also proved its connection with carcinogenesis and metastasis. This review summarizes recent advances in understanding the role of ELF3 in the following cancers: ampullary, bladder, breast, gastric, hepatocellular, nasopharyngeal, thyroid, lung and ovarian ones. State of knowledge: There are still many unresolved and undiscovered issues regarding ELF3 mutations, however, based on research since 2016, a link to many signaling pathways important for carcinogenesis has been shown. There is no simple correlation between a specific ELF3 mutation and effect on cancer cells. In various types of cancers, ELF3 is associated with other pathways, and modifications exerted by silencing or amplifying its or associated genes, cause different effects in patient prediction. An example of the effect of ELF3 on tumor progression is achieved by negatively regulating the ZEB1 transcription factor responsible for metastasis. WNT, RAS, Akt, mTOR, HER2, Cyclin D, IRF6 are other ELF3-related factors that affects pathways crucial for tumorigenesis. Conclusions: Further research and attempts to use ELF3 in the treatment and prognosis of cancer appear to be beneficial.
Źródło:
OncoReview; 2020, 10, 2; 77-81
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-19 z 19

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