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    Wyświetlanie 1-9 z 9
    Tytuł:
    Towards understanding the role of sialylation in melanoma progression
    Autorzy:
    Kolasińska, Ewa
    Przybyło, Małgorzata
    Janik, Marcelina
    Lityńska, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038776.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    integrins
    lectins
    melanoma
    progression
    sialic acids
    sialylation
    Opis:
    Aberrant expression of sialic acids or altered linkage types is closely associated with malignant phenotype and metastatic potential, and can have prognostic significance in human cancer. The present study was undertaken to evaluate whether expression of sialylated derivatives on melanoma cell surface is associated with tumour progression. Four cell lines (WM1552C, WM115, IGR-39 and WM266-4) were used in the study. Cell surface expression of sialic acids was evaluated by flow cytometry with the use of Maackia amurensis and Sambucus nigra lectins. Moreover, adhesion and migration potential of melanoma cells and involvement of sialic acids in these processes were analysed. We have demonstrated that WM266-4 cells have a significantly higher level of α2,3-linked sialic acid residues than other cells, whereas IGR-39 cells had lower expression of α2,6-linked sialic acids. The adhesion efficiencies of WM1552C and WM115 cells were significantly lower than that of IGR-39 and WM266-4 cells. In contrast, WM266-4 cells repaired scratch wounds at least twice as fast as other cells. Melanoma cell adhesion to fibronectin in the presence of Sambucus nigra agglutinin (SNA) was reduced only in IGR-39 and WM266-4 cells, whereas the impact of Maackia amurensis agglutinin (MAA) on this process was much more important. Migration efficiency of melanoma cells was reduced more strongly in the presence of MAA than SNA. In conclusion, our results show that melanoma progression is associated with the increased expression of α2,3-linked sialic acids on the cell surface and these residues could promote melanoma cell interaction with fibronectin.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 533-541
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ struktury mikrowypełniaczy krzemionkowych i ich synergicznych mieszanin na właściwości elektryczne i mechaniczne kompozytów epoksydowych
    The influence of micronsized fillers based on silica and its sinergic mixtures on electrical and mechanical properties of epoxy composites
    Autorzy:
    Brzeziński, Henryk
    Górecki, Lech
    Halama, Agnieszka
    Kolasińska, Ewa
    Warycha, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/304321.pdf
    Data publikacji:
    2019
    Wydawca:
    Wydawnictwo Druk-Art
    Tematy:
    kompozyt epoksydowy
    mączka kwarcowa
    mączka bazaltowa
    chalcedonit
    epoxy composite
    silica flour
    basalt flour
    chalcedonite
    Opis:
    Wyroby epoksydowe, stosowane w elektrotechnice jako elementy izolacyjne, powinny charakteryzować się wysoką wytrzymałością elektryczną i mechaniczną. Kompozycja epoksydowa po utwardzeniu nie spełnia takich wymagań. Dlatego też materiały te wypełnia się dodatkami mineralnymi, wśród których najpopularniejsze są te bazowane na tlenku krzemu. W artykule porównano wpływ trzech mikrowypełniaczy (mączka kwarcowa, mączka bazaltowa, chelcedonit) w kompozytach z matrycą dianową na właściwości mechaniczne (wytrzymałość na zginanie) oraz elektryczne (wytrzymałość na przebicie). Wszystkie kompozyty otrzymywano z zastosowaniem takiej samej technologii, wprowadzając 60% wag. dodatków mineralnych w postaci czystej lub równowagowej mieszaniny dwóch różnych minerałów. Dodatkowo zbadano właściwości termiczne i morfologiczne zastosowanych wypełniaczy z użyciem metod analizy termicznej i mikroskopii skaningowej.
    Epoxy – based products applied in electrotechnical engineering as insulating elements, should be highly mechanical and electrical resistant. Neat, cured epoxy resin, however, does not reach sufficient parameters. Thus, these materials are being reinforced by addition of mineral fillers, where the most popular are based on silicon dioxide. In the article, the influence of three micronsized fillers (silica flour, basalt flour, chalcedonite) with the epoxy matrix were compared. All composites were prepared according to the same technology. The fillers were added in the pristine form in the amount of 60%wt, as well as mixed and incorporated in the summary amount equal 60%wt. As a basis of comparison, the values of mechanical and electrical resistance were taken. Additionally, morphological (SEM) and thermal analysis of the fillers were done.
    Źródło:
    Napędy i Sterowanie; 2019, 21, 11; 76-79
    1507-7764
    Pojawia się w:
    Napędy i Sterowanie
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ struktury mikrowypełniaczy krzemionkowych na właściwości elektryczne i mechaniczne kompozytów epoksydowych
    The influence of micronsized fillers based on silica on electrical and mechanical properties of epoxy composites
    Autorzy:
    Brzeziński, H.
    Górecki, Lech
    Halama, Agnieszka
    Kolasińska, Ewa
    Warycha, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1196858.pdf
    Data publikacji:
    2019
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Napędów i Maszyn Elektrycznych Komel
    Tematy:
    kompozyty epoksydowe
    mączka kwarcowa
    mączka bazaltowa
    chalcedonit
    epoxy composites
    silica flour
    basalt flour
    chalcedonite
    Opis:
    Epoxy – based products applied in electrotechnical engineering as insulating elements, should be highly mechanical and electrical resistant. Neat , cured epoxy resin, however, does not reach sufficient parameters. Thus, these materials are being reinforced by addition of mineral fillers, where the most popular are based on silicon dioxide. In the article, the influence of three micronsized fillers (silica flour, basalt flour, chalcedonite) with the epoxy matrix were compared. All composites were prepared according to the same technology. The fillers were added in the amount of 60 %wt, as well as mixed and incorporated in the summary amount equal 60 %wt. As a basis of comparison, the values of mechanical and electrical resistance were taken. Additionally, morphological (SEM) and thermal analysis of the fillers were done.
    Wyroby epoksydowe stosowane w elektrotechnice, jako elementy izolacyjne, powinny charakteryzować się wysoką wytrzymałością elektryczną i mechaniczną. Kompozycja epoksydowa, po utwardzeniu nie spełnia takich wymagań. Dlatego też materiały te wypełnia się dodatkami mineralnymi, wśród których najpopularniejsze są te bazowane na tlenku krzemu. W artykule porównano wpływ trzech mikrowypełniaczy (mączka kwarcowa, mączka bazaltowa, chelcedonit) w kompozytach z matrycą dianową na właściwości mechaniczne (wytrzymałość na zginanie) oraz elektryczne (wytrzymałości na przebicie). Kompozyty otrzymywano z zastosowaniem takiej samej technologii przetwórstwa, wprowadzając 60% wag. dodatków w postaci czystej lub mieszanej. Dodatkowo, zbadano właściwości termiczne i morfologiczne zastosowanych wypełniaczy z użyciem metod: analiza termiczna i mikroskopia skaningowa.
    Źródło:
    Maszyny Elektryczne: zeszyty problemowe; 2019, 1, 121; 33-36
    0239-3646
    2084-5618
    Pojawia się w:
    Maszyny Elektryczne: zeszyty problemowe
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Tradition, the Present and Future of the Sociology of Work in Poland: Reflections on the Project the Doyens of the Sociology of Work in Poland
    Autorzy:
    Giermanowska, Ewa
    Kolasińska, Elżbieta
    Mrozowicki, Adam
    Róg-Ilnicka, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/942285.pdf
    Data publikacji:
    2016
    Wydawca:
    Szkoła Główna Handlowa w Warszawie
    Tematy:
    doyens of sociology of work
    plant sociolgists
    institutionalisation of the sociology of work
    the crisis of sociology of work
    Polska
    Opis:
    This article explores the experiences of the institutionalization and crisis of the sociology of work in Poland by analyzing the narratives of the doyens of the sociology of work in the country. It is argued that the institutionalization of sociology of work in the 1960s and 1970s reflected the requirements of the socialist industrialization of the country and its crisis (lasting from the end of 1980s) has political and economic roots related to systemic transformation. Simultaneously, some parallels between the situation of the sociology of work before and after 1989 are noted, including the challenges of cooperation between sociologists and industry. The empirical data in the article come from the research project carried out the Sociology of Work Section of the Polish Sociological Association based on the narrative interviews with the academic sociologists of work and plant sociologists who began their careers in the period of state socialism in Poland.
    Źródło:
    Warsaw Forum of Economic Sociology; 2016, 7, 13; 89-104
    2081-9633
    Pojawia się w:
    Warsaw Forum of Economic Sociology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Spectrum of gluten-related disorders: celiac disease, wheat allergy, baker’s asthma and non-celiac gluten sensitivity
    Autorzy:
    Kolasińska, Karolina
    Kwiatkowski, Stanisław
    Czerwiński, Grzegorz
    Poniewierka, Elżbieta
    Waszczuk, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1177771.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    celiac disease
    gluten
    non-celiac gluten sensitivity
    wheat allergy
    Opis:
    Gluten, which is a protein found in wheat, can trigger some gastrointestinal diseases in people with genetic predisposition. Gluten related disorders include celiac disease (CD), wheat allergy, baker’s asthma and non-celiac gluten sensivity (NCGS). Approximately 1% of population suffers from celiac disease. It is believed, that the occurrence of the disease is determined by the interaction of genetic, immunological and environmental factors. The consequence of the inflammatory process is the atrophy of the intestinal villi. That results in impaired bowel motility, improper digestion and impaired absorption of substances contained in the diet. Wheat allergy occurs among people with a genetic predisposition to allergies. People with this disorder are sensitized to products containing gluten and every contact with this antigen leads to mast cell activation and the release of mediators of the allergic reaction - mainly histamine. They mainly affect the skin (urticaria, atopic eczema, angioedema), digestive system (nausea, vomiting, spasmic abdominal pain) and respiratory tract (asthma, allergic rhinitis). Baker’s asthma is an interesting and common allergic, occupational disorder related to inhalation of flour containing gluten. The main symptoms include: conjunctivitis, rhinitis, dermatitis, as well as work-related cough and dyspnea. First reports on non-celiac gluten sensitivity (NCGS) appeared in 1980. The diagnosis of non-celiac gluten sensitivity is based on the exclusion of celiac disease and food allergy in a patient who has symptoms induced by ingestion of gluten. The exact pathomechanism of this disease is still unknown. Interestingly, some researches doubt that this disorder is caused by gluten intake. All of the above-mentioned diseases have a similar spectrum of clinical symptoms, and as part of the treatment require an elimination diet with the exclusion of gluten. The aim of this study is to provide information on gluten-related diseases, taking into account their pathomechanism and clinical picture.
    Źródło:
    World Scientific News; 2018, 100; 154-164
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Competences 4.0 in the logistics sector against the challenges of sustainable digital transformation of the economy in the Polish perspective
    Autorzy:
    Brzozowska, Marta
    Kaczmarska-Krawczak, Jadwiga
    Kolasińska-Morawska, Katarzyna
    Stroińska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/27313488.pdf
    Data publikacji:
    2022
    Wydawca:
    Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
    Tematy:
    digitization
    competences 4.0
    sustainable economy
    logistics
    cyfryzacja
    kompetencje 4.0
    zrównoważona gospodarka
    logistyka
    Opis:
    Purpose: The aim of the paper was the identification of 4.0 competences that should be characterized by logistics workers in the era of the fourth industrial revolution. Design/methodology/approach: First step was the desk research analysis of source material (monographic studies, publications and reports). The second step were primary (fragmentary) explanatory, descriptive and explanatory, focused on the implementation of one research goal. The method used in the course of the study was the "user-centric" CAWI (Computer Assisted Web Interview). Findings: Technologization and robotization require from employees to acquire new digital competences. Studies show that logistics workers are aware of the needed change. There is a need to acquire competences 4.0 which can consist of cognitive, informative and technical competences. Research limitations/implications: The main limitation of the research was the availability of employees in logistics companies and the precise division of enterprises in which the respondents were employed. In the available statistical summaries and address databases, there is no division taking into account the place of logistics as an element of business activities in enterprises. Practical implications: Research can be also a signpost for employers of what kind of competences should be developed in the future in the face of upcoming economy 5.0 and society 5.0. Originality/value: The article can be a road-map for sustainable digital transformation taking into account not only machines but also human beings.
    Źródło:
    Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska; 2022, 162; 55--85
    1641-3466
    Pojawia się w:
    Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The guide through brain-gut-enteric microbiota axis – regulation pathways and related disorders
    Autorzy:
    Kolasińska, Karolina
    Kwiatkowski, Stanisław
    Knap, Bartosz
    Czerwiński, Grzegorz
    Poniewierka, Elżbieta
    Waszczuk, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1163424.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    brain-gut axis
    enteric microbiota
    gastrointestinal system
    Opis:
    The brain-gut axis is a complex system of connections between the central nervous system (CNS) and the digestive tract. Information within the axis is transmitted through many pathways (neural, endocrine, metabolic, immunological) and is strongly dependent on the microbiota inhabiting the gut. Therefore, the brain-gut axis is also called the “brain-gut-enteric microbiota axis”. Many studies are carried out to determine how it functions but the exact mechanism is still poorly understood. Unraveling the mystery of brain-gut-enteric microbiota axis seems to be crucial in understanding of many diseases and processes governing the human body.
    Źródło:
    World Scientific News; 2018, 109; 115-130
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Helicobacter pylori infection: from biology to clinical features
    Autorzy:
    Kolasińska, Karolina
    Kwiatkowski, Stanisław
    Knap, Bartosz
    Czerwiński, Grzegorz
    Poniewierka, Elżbieta
    Waszczuk, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1165561.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Helicobacter pylori
    MALT lymphoma
    gastric cancer
    peptic ulcer disease
    Opis:
    The discovery of bacterium Helicobacter pylori and the association of its occurrence with gastritis and peptic ulcer disease, was one of the most significant events of the 20th century. Almost 40 years have passed since that event, but we are still far from fully understanding of the impact of H. pylori infection on the human body. It is confirmed, that the infection causes chronic gastritis, which increases the risk of diseases such as: duodenal and/or gastric ulcer, gastric cancer and gastric MALT lymphoma. Nevertheless, constantly appear new studies linking H. pylori with many other disorders, often not directly related to the digestive system. Cardiovascular, neurological, hematological, dermatological, metabolic and also gynecological diseases are in sphere of assumptions. The authors of the following work attempted to select key information available in the medical literature on the discovery of H. pylori, epidemiology and pathophysiology of infection, as well as diseases to which it predisposes and the latest methods of eradication.
    Źródło:
    World Scientific News; 2018, 107; 171-184
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Azapirones for the treatment of anxiety – an overview
    Autorzy:
    Knap, Bartosz
    Kwiatkowski, Stanisław
    Kolasińska, Karolina
    Knap-Czop, Karolina
    Przystupski, Dawid
    Roguzińska, Sylwia
    Kędzierska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1163274.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    anxiety disorder
    azapirones
    buspirone
    gepirone
    ipsapirone
    tandospirone
    Opis:
    Anxiety disorders belong to the most common psychiatric diagnosis. Over the years, benzodiazepines were considered the gold standard for pharmacological treatment of anxiety. They are effective anxiolytics, but unfortunately the long-term use of benzodiazepines is accompanied by many adverse events. An alternative to classical anxiolytics is a relatively new class of psychotherapeutic drugs – azapirones. They are 5-HT1A partial agonists commonly used in the treatment of generalized anxiety disorder and as augmentation for SSRI in social anxiety disorder and depression. Due to the high ratio of benefits to risk, azapirones are extensively studied for their use in other disease entities. The aim of this article was to overviewed current information on azapirones. Their history of development, mechanism of action, pharmacokinetics, interactions, clinical use and their role in the modern pharmacotherapy of anxiety.
    Źródło:
    World Scientific News; 2018, 109; 14-25
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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