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Wyświetlanie 1-12 z 12
Tytuł:
Dynamics of estrogen-induced oxidative stress
Autorzy:
Kobiela, Jarek
Stefaniak, Tomasz
Krajewski, Jacek
Kalinska-Blach, Beata
Zurawa-Janicka, Dorota
Lachinski, Andrzej
Gackowski, Daniel
Olinski, Ryszard
Nowak, Jerzy
Knap, narcyz
Lipinska, Barbara
Sledzinski, Zbigniew
Wozniak, Michal
Powiązania:
https://bibliotekanauki.pl/articles/1041076.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
8-oxodGuo
estradiol
protein oxidation
carcinogenesis
DNA damage
lipid peroxidation
Opis:
The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 289-295
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
METODOLOGIA BADANIA KULTURY ORGANIZACYJNEJ
Autorzy:
Jagodziński, Andrzej
Knap, Radosław
Powiązania:
https://bibliotekanauki.pl/articles/446974.pdf
Data publikacji:
2013
Wydawca:
Mazowiecka Uczelnia Publiczna w Płocku
Opis:
Key words: organizational culture, scientific research, research stages, researchproblems, research instruments, (dependent variable), (independent variables).SummaryEvery organization represents two levels: an open one - conscious and implicit -unconscious.Apart from the open mission, aims and tasks each organization also represents values,needs or standards of behaviour which are not realized by the majority ofemployees and which vitally affect the company’s operation. This study proves thatthe pro-effective culture enhances the company’s attractiveness as an employer, itpositively influences employees’ motivation and loyalty and makes up a decisivefactor in the process of attracting the most talented candidates to work. In order toachieve it the companies must first recognize and then implement the common valuesand standards characterizing a given culture of the organization. The questionis: how to examine the company’s organizational culture?The present paper makes up an attempt of presenting the research methodology ofthe organizational culture. The authors quite clearly and comprehensibly informhow to conduct the research which is to lead to the proper diagnosis of the organizationalculture.Metodologia badania kultury organizacyjnej
Źródło:
Zeszyty Naukowe PWSZ w Płocku. Nauki Ekonomiczne; 2013, 18
1644-888X
Pojawia się w:
Zeszyty Naukowe PWSZ w Płocku. Nauki Ekonomiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-12 z 12

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