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Tytuł:
Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats
Autorzy:
Zou, Liu
Xiong, Shujuan
Deng, Xiangping
Liu, Juan
Xiong, Runde
Wang, Zhe
Cao, Xuan
Chen, Yanming
Guo, Yu
Tang, Guotao
Powiązania:
https://bibliotekanauki.pl/articles/895637.pdf
Data publikacji:
2018-12-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
scutellarin
TPGS
polymeric micelles
antithrombotic drugs
Opis:
To improve the clinical effect of scutellarin by extending the action time in vivo, scutellarin loaded polymeric micelles were developed by D-alpha tocopherol polyethylene glycol 1000 succinate (Scu/TPGS). Scu/TPGS were prepared using film solvent diffusion methods and characterized on the basis of their particle size, zeta potential, and drug encapsulation efficiency. Dynamic dialysis was used to study the release behavior of the polymeric micelles in vitro. Its pharmacokinetic characteristics and antithrombotic efficacy were studied by intravenous injection in rats. The results showed that Scu/TPGS were spherical, 20.09±2.62 nm in size and a slow release in vitro. The pharmacokinetic parameter T1/2 of Scu/TPGS was 762.12±46.56 min compared with commercial injection of 59.30±10.67 min (p<0.05). At the 1 mg/kg dose, the thrombolysis effect of micellar group was stronger than that of the commercial group (p<0.05). In conclusion, TPGS polymer micelles provided a valid strategy in chemotherapy for cerebrovascular diseases with poor water solubility and poor lipid solubility drugs such as scutellarin.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1305-1312
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studies on diversity of soil microfungi in the Hornsund area, Spitsbergen
Autorzy:
Convey, Peter
Siti Hafizah, Hafizah
Alias Siti Aisyah
Siang Hii Yii
Smykla, Jerzy
Pang, Ka−lai
Guo Sheng−yu
Powiązania:
https://bibliotekanauki.pl/articles/2051415.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Arctic
Svalbard
soil microbiology
microfungi
Źródło:
Polish Polar Research; 2013, 1; 39-54
0138-0338
2081-8262
Pojawia się w:
Polish Polar Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Medium- and long-term prediction of polar motion using weighted least squares extrapolation and vector autoregressive modeling
Autorzy:
Lei, Yu
Zhao, Danning
Guo, Min
Powiązania:
https://bibliotekanauki.pl/articles/27314482.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Centrum Badań Kosmicznych PAN
Tematy:
polar motion
prediction model
weighted least squares
vector autoregressive
Opis:
This article presents the application of weighted least squares (WLS) extrapolation and vector autoregressive (VAR) modeling in polar motion prediction. A piecewise weighting function is developed for the least squares (LS) adjustment in consideration of the effect of intervals between observation and prediction epochs on WLS extrapolation. Furthermore, the VAR technique is used to simultaneously model and predict the residuals of xp, yp pole coordinates for WLS misfit. The simultaneous predictions of xp, yp pole coordinates are subsequently computed by the combination of WLS extrapolation of harmonic models for the linear trend, Chandler and annual wobbles, and VAR stochastic prediction of the residuals (WLS+VAR). The 365-day-ahead xp, yp predictions are compared with those generated by LS extrapolation+univariate AR prediction and LS extrapolation+VAR modeling. It is shown that the xp, yp predictions based on WLS+VAR taking into consideration both the interval effect and correlation between xp and yp outperform those generated by two others. The accuracies of the xp predictions are 13.97 mas, 18.47 mas, and 20.52 mas, respectively for the 150-, 270-, and 365-day horizon in terms of the mean absolute error statistics, 36%, 24.8%, and 33.5% higher than LS+AR, respectively. For the yp predictions, the 150-, 270-, and 365-day accuracies are 15.41 mas, 21.17 mas, and 21.82 mas respectively, 27.4%, 11.9%, and 21.8% higher than LS+AR respectively. Moreover, the absolute differences of the WLS+VAR predictions and observations are smaller than the differences from LS+VAR and LS+AR, which is practically important to practical and scientific users, although the improvement in accuracies is no more than 10% relative to LS+VAR. The further comparison with the predictions submitted to the 1st Earth Orientation Parameters Prediction Comparison Campaign (1st EOP PCC) shows that while the accuracy of the predictions within 30 days is comparable with that by the most accurate prediction techniques including neural networks and LS+AR participating in the campaign for xp, yp pole coordinates, the accuracy of the predictions up to 365 days into the future are better than accuracies by the other techniques except best LS+AR used in the EOP PCC. It is therefore concluded that the medium- and long-term prediction accuracy of polar motion can be improved by modeling xp, yp pole coordinates together.
Źródło:
Artificial Satellites. Journal of Planetary Geodesy; 2023, 58, 2; 42--55
2083-6104
Pojawia się w:
Artificial Satellites. Journal of Planetary Geodesy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Numerical and experimental investigation on nonlinear dynamic characteristics of planetary gear train
Autorzy:
Zhang, Jianwu
Guo, Han
Yu, Haisheng
Zhang, Tong
Powiązania:
https://bibliotekanauki.pl/articles/1839620.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
deep hybrid transmission
power split devices
lumped parameter model
dynamic instability
Opis:
A deep hybrid electric vehicle (DHEV) equipped with a Ravigneaux compound planetary gear train (PGT) encounters severe gear whine noises during acceleration in the EV drive mode. For the analysis of vibro-acoustic sources, a 5DOF lumped-parameter vibration model for the PGT dynamic system is established as well as sound pressures radiated from the transmission on a test bench are measured for data processing and recognition. By comparison between numerical and experimental analyses, natural vibration modes of the PGT are examined and high frequency modal resonances in association with the planetary gears are observed only to cause narrow band whine noises. Furthermore, a 2DOF reduced dynamic model for the planetary gears with consideration of nonlinearities such as time-varying mesh stiffness and backlash is proposed, and numerical solutions to bifurcations and dynamic instabilities of the two sets of planetary gears are obtained. It is found that nonlinear vibration behaviour of the long and short planets are major causes of shock and vibration of the hybrid transmission. Severe vibro-acoustic noises excited dominantly by the planetary gears are alleviated after implementing micro-geometry modifications to the PGT.
Źródło:
Journal of Theoretical and Applied Mechanics; 2020, 58, 4; 1009-1022
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distribution and sources of n-alkanes in surface sediments of Taihu Lake, China
Autorzy:
Yu, Y.
Li, Y.
Guo, Z.
Zou, H.
Powiązania:
https://bibliotekanauki.pl/articles/205298.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
n-alkanes
surface sediments
Taihu Lake
Opis:
The last study on n-alkanes in surface sediments of Taihu Lake was in 2000, only 13 surface sediment samples were analysed, in order to have a comprehensive and up-to-date understanding of n-alkanes in the surface sediments of Taihu Lake, 41 surface sediment samples were analyzed by GC-MS. C10 to C37 were detected, the total concentrations of n-alkanes ranged from 2109 ng g−1 to 9096 ng gg−1 (dry weight). There was strong odd carbon predominance in long chain n-alkanes and even carbon predominance in short chain n-alkanes. When this finding was combined with the analysis results of wax n-alkanes (WaxCn), carbon preference index (CPI), unresolved complex mixture (UCM), hopanes and steranes, it was considered that the long chain n-alkanes were mainly from terrigenous higher plants, and that the short chain n-alkanes mainly originated from bacteria and algae in the lake, compared with previous studies, there were no obvious anthropogenic petrogenic inputs. Terrestrial and aquatic hydrocarbons ratio (TAR) and C21−/C25+ indicated that terrigenous input was higher than aquatic sources and the nearshore n-alkanes were mainly from land-derived sources. Moreover, the distribution of short chain n-alkanes presented a relatively uniform pattern, while the long chain n-alkanes presented a trend that concentrations dropped from nearshore places to the middle of lake.
Źródło:
Archives of Environmental Protection; 2016, 42, 1; 49-55
2083-4772
2083-4810
Pojawia się w:
Archives of Environmental Protection
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Indoor positioning based on foot-mounted IMU
Autorzy:
Guo, H.
Uradziński, M.
Yin, H.
Yu, M.
Powiązania:
https://bibliotekanauki.pl/articles/201400.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
indoor positioning
foot-mounted
pedestrian dead reckoning
IMU
ZARU
ZUPT
Opis:
The paper presents the results of the project which examines the level of accuracy that can be achieved in precision indoor positioning by using a pedestrian dead reckoning (PDR) method. This project is focused on estimating the position using step detection technique based on foot-mounted IMU. The approach is sensor-fusion by using accelerometers, gyroscopes and magnetometers after initial alignment is completed. By estimating and compensating the drift errors in each step, the proposed method can reduce errors during the footsteps. There is an advantage of the step detection combined with ZUPT and ZARU for calculating the actual position, distance travelled and estimating the IMU sensors’ inherent accumulated error by EKF. Based on the above discussion, all algorithms are derived in detail in the paper. Several tests with an Xsens IMU device have been performed in order to evaluate the performance of the proposed method. The final results show that the dead reckoning positioning average position error did not exceed 0.88 m (0.2% to 1.73% of the total traveled distance – normally ranges from 0.3% to 10%), what is very promising for future handheld indoor navigation systems that can be used in large office buildings, malls, museums, hospitals, etc.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2015, 63, 3; 629-634
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Availability analysis for a multi-component system with different k-out-of-n:G warm standby subsystems subject to suspended animation
Analiza gotowości systemu wieloelementowego składającego się z różnych wygaszalnych podsystemów typu k-z-n:G stanowiących rezerwę ciepłą
Autorzy:
Wang, Yu
Guo, Linhan
Wen, Meilin
Yang, Yi
Powiązania:
https://bibliotekanauki.pl/articles/1365298.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
availability
multi-component series system
k-out-of-n:G warm standby subsystem
suspended animation
Markov process
gotowość
wieloelementowy system szeregowy
podsystem k-z-n:G
rezerwa ciepła
wygaszanie
proces Markowa
Opis:
Industrial equipment or systems are usually constructed as a multi-component series system with k-out-of-n:G subsystems to fulfill a specified function. As a common type of standby, warm standby is considered in the multi-component series system with k-outofn:G standby subsystems. When a subsystem fails, the non-failed subsystems are shut off and cannot fail, which is defined as suspended animation (SA). If the SA is ignored the non-failed subsystems are assumed to keep working in the SA time, which will cause inaccuracy in the availability analysis for the system. In this paper, we focus on the SA to construct an availability model for a multi-component series system with k-out-of-n:G warm standby subsystems. Multiple continuous time Markov chains are constructed to model the system availability. A Monte Carlo simulation has been carried out to verify our method. Several interesting findings are obtained. 1) The failure rates of subsystems with SA and their limits are derived. 2) The closed-form expressions for the stationary availability of the system and subsystems, mean time to failure, mean time to repair and stationary failure frequency are obtained considering SA. 3) The system stationary availability is a monotone function for its parameters. 4) The SA effect on the stationary availability should be emphasized in two cases, one is both the value of n/k and the failure rate of active components in a k-out-of-n subsystem are relatively large or small, the other is both the value of n/k and the repair rate are relatively small.
Aby urządzenia i systemy przemysłowe mogły pełnić swoje określone funkcje, zwykle buduje się je w postaci wieloelementowych systemów szeregowych składających się z podsystemów typu k-z-n: G. W pracy rozważano zagadnienie rezerwy ciepłej w wieloelementowym systemie szeregowym składającym się z podsystemów rezerwowych typu k-z-n: G. W przypadku awarii jednego z takich podsystemów, pozostałe, działające podsystemy wyłącza się, dzięki czemu nie mogą one ulec uszkodzeniu. Procedurę taką określa się, przez analogię z organizmami żywymi mianem anabiozy (suspended animation) lub wygaszania. Pominięcie zjawiska wygaszania, prowadzi do założenia, że podsystemy, które nie uległy uszkodzeniu pracują w czasie wygaszenia, co skutkuje nieprawidłowościami w analizie gotowości systemu. W artykule koncepcję wygaszania podsystemów wykorzystano do budowy modelu gotowości wieloelementowego systemu szeregowego składającego się z podsystemów typu k-z-n: G stanowiących rezerwę ciepłą. W celu zamodelowania gotowości systemu, skonstruowano łańcuchy Markowa z czasem ciągłym. Przedstawioną metodę zweryfikowano za pomocą symulacji Monte Carlo. Uzyskano szereg interesujących wyników. 1) Obliczono intensywność uszkodzeń podsystemów wygaszonych i ich wartości graniczne. 2) Wyprowadzono, z uwzględnieniem procedury wygaszania, wyrażenia w postaci zamkniętej dla stacjonarnej gotowości rozważanego systemu i podsystemów oraz określono średni czas do uszkodzenia, średni czas do naprawy oraz stacjonarną częstotliwość uszkodzeń. 3) Gotowość stacjonarna systemu jest funkcją monotoniczną dla parametrów wejściowych systemu. 4) Należy podkreślić wpływ wygaszania na stacjonarną gotowość systemu w dwóch przypadkach: gdy stosunek n/k i intensywność uszkodzeń aktywnych elementów k-tego spośród n podsystemów są względnie niskie lub względnie wysokie, oraz gdy stosunek n/k i intensywność napraw są względnie niskie.
Źródło:
Eksploatacja i Niezawodność; 2019, 21, 2; 289-300
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A method for designing the longitudinal position of a porthole in a manned submersible based on the back muscle fatigue characteristics
Autorzy:
Zhu, Mengya
Chen, Dengkai
Fan, Yu
Guo, Jiayan
Powiązania:
https://bibliotekanauki.pl/articles/2094205.pdf
Data publikacji:
2021-12-13
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
surface electromyography
muscle fatigue
work efficiency
manned submersible
porthole position design
oceanauts
Opis:
ObjectivesThe proper porthole angle contributes to relieving the operation fatigue and improving the efficiency of oceanauts. In this study, the authors explored the effect of 3 different porthole longitudinal positions on the oceanauts’ back muscles using surface electromyography (sEMG) analysis, and the characteristics of the perceived body comfort was obtained.Material and MethodsOverall, 40 healthy participants were recruited to perform tasks in a simulated cabin environment. Electromyographic (EMG) signals were recorded from the trapezius medius, lower trapezius, and erector spinal muscles for porthole angles of –5°, –15°, and +15°, relative to the horizontal line of sight during a 21-minute experiment. The subject comfort scores were collected at 7, 14 and 21 min. The integrated electromyogram (iEMG) and the root mean square (RMS) of EMG signals, as well as the mean power frequency (MPF), and the mean frequency (MF) were calculated.ResultsThe subjective scores of the +15° porthole at each stage of work are higher than those of the –15° and –5° portholes. The results of iEMG, RMS, MF and MPF all indicated that the +15° porthole design was more conducive to lowering the rate of muscle fatigue, while the –5° and –15° portholes increased the muscle fatigue rate and led to greater fatigue. It was found that the lower trapezius was more prone to fatigue than the trapezius medius and erector spinal muscles. The height, weight and body mass index of the participants were found to negatively correlate with muscles at the +15° porthole, which is highly consistent with the actual situation.ConclusionsThe findings suggested that the +15° position was optimal for delaying the muscle fatigue of the participants and for improving the work efficiency of oceanauts.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2021, 34, 6; 701-721
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Improved upper bounds for nearly antipodal chromatic number of paths
Autorzy:
Shen, Yu-Fa
Zheng, Guo-Ping
He, Wen-Jie
Powiązania:
https://bibliotekanauki.pl/articles/743717.pdf
Data publikacji:
2007
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
radio colorings
nearly antipodal chromatic number
paths
Opis:
For paths Pₙ, G. Chartrand, L. Nebeský and P. Zhang showed that $ac'(Pₙ) ≤ \binom{n-2}{2} + 2$ for every positive integer n, where ac'(Pₙ) denotes the nearly antipodal chromatic number of Pₙ. In this paper we show that $ac'(Pₙ) ≤ \binom{n-2}{2} - n/2 - ⎣10/n⎦ + 7$ if n is even positive integer and n ≥ 10, and $ac'(Pₙ) ≤ \binom{n-2}{2} - (n-1)/2 - ⎣13/n⎦ + 8$ if n is odd positive integer and n ≥ 13. For all even positive integers n ≥ 10 and all odd positive integers n ≥ 13, these results improve the upper bounds for nearly antipodal chromatic number of Pₙ.
Źródło:
Discussiones Mathematicae Graph Theory; 2007, 27, 1; 159-174
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Y2O3 on Microstructure and Corrosion Properties of Laser Cladding Composite Coatings on 304 Stainless Steel Substrate
Autorzy:
Yu, Jinling
Zhentai, Zheng
Li, Shuai
Guo, Donghui
Chang, Liang
Powiązania:
https://bibliotekanauki.pl/articles/27313865.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
laser cladding
Ni-based coatings
electrochemical corrosion
Opis:
Ni625/WC composite coatings added with different amounts of Y2O3 were prepared on the surface of 304 stainless steels by laser cladding. This study focused on the microstructure characteristics, microhardness, and corrosion performances of Ni625/WC composite coatings. The results showed that Y2O3 can effectively improve the corrosion resistance of the composite coatings. The microstructure from the bottom to the surface of composite coatings consists of plane crystal, cellular crystal, columnar crystal and equiaxed crystal. The Y2O3 content of optimum composite coating was 1.0%. Its microhardness was three times that of matrix material. In addition, the corrosion current density of the composite coating was only 2% of Ni625/WC coating, which was attributed to the good properties of Y2O3 and appropriate Y2O3 refined microstructure.
Źródło:
Archives of Metallurgy and Materials; 2023, 68, 2; 447--453
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A model-free direct predictive grid-current control strategy for grid-connected converter with an inductance-capacitance-inductance filter
Autorzy:
Guo, Leilei
Zheng, Mingzhe
Yu, Changzhou
Xu, Haizhen
Li, Yanyan
Powiązania:
https://bibliotekanauki.pl/articles/2202543.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
grid-connected converter
GCC
model-free predictive current control
MFPCC
parameter mismatch
robustness
Opis:
The disadvantages of the conventional model predictive current control method for the grid-connected converter (GCC) with an inductance-capacitance-inductance (LCL) filter are a large amount of calculation and poor parameter robustness. Once parameters of the model are mismatched, the control accuracy of model predictive control (MPC) will be reduced, which will seriously affect the power quality of the GCC. The article intuitively analyzes the sensitivity of parameter mismatch on the current predictive control of the conventional LCL-filtered GCC. In order to solve these issues, a model-free predictive current control (MFPCC) method for the LCL-filtered GCC is proposed in this paper. The contribution of this work is that a novel current predictive robust controller for the LCL-filtered GCC is designed based on the principle of the ultra-local model of a single input single output system. The proposed control method does not require using any model parameters in the controller, which can effectively suppress the disturbances of the uncertain parameter variations. Compared with conventional MPC, the proposed MFPCC has smaller current total harmonic distortion (THD). When the filter parameters are mismatched, the control error of the proposed method is smaller. Finally, a comparative experimental study is carried out on the platform of Typhoon and PE-Expert4 to verify the superiority and effectiveness of the proposed MFPCC method for the LCL-filtered GCC.
Źródło:
Archives of Electrical Engineering; 2023, 72, 1; 23--42
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Internal Friction Study on the Influence of Pre-Deformation on Hydrogen Embrittlement Sensitivity of Dual-Phase Steel
Autorzy:
Pang, Qihang
Geng, Cong
Wang, Jiaji
Li, Weijuan
Guo, Jing
Yu, Xiaoming
Powiązania:
https://bibliotekanauki.pl/articles/2174553.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dual phase steel
hydrogen embrittlement
γ peak
SKK peak
dislocation density
Opis:
In this study, an electrochemical method was used to permeate hydrogen through annealed DP590 steel under various pre-strain conditions (0-15%). Stress-strain and internal friction-temperature curves of the dual phase (DP) steel were obtained from slow strain-rate tensile tests and internal friction measurements, respectively. The diffusion of interstitial atoms, formation of Cottrell atmospheres, and embrittlement mechanism of DP steel were investigated under different prestress conditions before and after hydrogen permeation. The results show that the tensile strength of DP steel first decreases and then increases and the elongation sharply decreases with increasing pre-strain. The strength and ductility present similar trends with changes in pre-strain before and after hydrogen charging, however, after hydrogen charging, an obvious increase in tensile strength and decrease in elongation are observed. Furthermore, the γ peak amplitude decreases and the Snoek-Ke-Koster (SKK) peak amplitude increases with increasing internal pre-strain according to the friction-temperature curve. The γ peak and SKK peak exhibit the same trends with increasing pre-strain before and after hydrogen charging and both the γ peak and SKK peak decrease with hydrogen charging. The dislocation density in DP steel increases after hydrogen charging.
Źródło:
Archives of Metallurgy and Materials; 2022, 67, 4; 1315--1324
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dose-effect relationship on anti-inflammatory activity on LPS induced RAW 264.7 cells and antioxidant activity of rutin in vitro
Autorzy:
tian, chunlian
guo, yuru
chang, yu
zhao, jihang
cui, cancan
liu, mingchun
Powiązania:
https://bibliotekanauki.pl/articles/895707.pdf
Data publikacji:
2019-06-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
antioxidant
Anti-inflammatory
lipopolysaccharide
rutin
dose-effect relationship
Opis:
Rutin, as a common flavonol glycoside, exists abundantly in many plants and exhibits various nutritional and pharmacological function. Current study focused on the dose-effect relationship of rutin on the anti-inflammatory and antioxidant activities in vitro against LPS-stimulated RAW 264.7 cells and free radicals or ferric-ion. This study evaluated the anti-inflammatory activity by observation cell morphological and determination of the content of NO, TNF-α, IL-1β and IL-6, and the phagocytic activity in LPS induced RAW 264.7 cells; and revealed the antioxidant activities via assay of DPPH radical scavenging capacity, ABTS radical scavenging capacity, and reducing power. The study indicated that 5, 10, 20, 50 and 100 μM of rutin all exhibited a better anti-inflammatory activity, in especial 50 and 100 μM. Meanwhile, it exerted a stronger antioxidant activities than BHT, and equivalent to VC at the same concentration. Combined, the results suggested that rutin will be a potential and important adjuvant in treatment of inflammatory diseases and oxidative stress.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 511-522
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On choosability of complete multipartite graphs $K_{4,3*t,2*(k-2t-2),1*(t+1)}$
Autorzy:
Zheng, Guo-Ping
Shen, Yu-Fa
Chen, Zuo-Li
Lv, Jin-Feng
Powiązania:
https://bibliotekanauki.pl/articles/744583.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
list coloring
complete multipartite graphs
chromatic-choosable graphs
Ohba's conjecture
Opis:
A graph G is said to be chromatic-choosable if ch(G) = χ(G). Ohba has conjectured that every graph G with 2χ(G)+1 or fewer vertices is chromatic-choosable. It is clear that Ohba's conjecture is true if and only if it is true for complete multipartite graphs. In this paper we show that Ohba's conjecture is true for complete multipartite graphs $K_{4,3*t,2*(k-2t-2),1*(t+1)}$ for all integers t ≥ 1 and k ≥ 2t+2, that is, $ch(K_{4,3*t,2*(k-2t-2),1*(t+1)}) = k$, which extends the results $ch(K_{4,3,2*(k-4),1*2}) = k$ given by Shen et al. (Discrete Math. 308 (2008) 136-143), and $ch(K_{4,3*2,2*(k-6),1*3}) = k$ given by He et al. (Discrete Math. 308 (2008) 5871-5877).
Źródło:
Discussiones Mathematicae Graph Theory; 2010, 30, 2; 237-244
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An early warning method for a slope based on the increment ratio of anchor cable internal force
Autorzy:
Feng, Jianhua
Chen, Jiaxin
Li, Jian
Zhang, Yu
Guo, Jianhua
Qiu, Hongyong
Powiązania:
https://bibliotekanauki.pl/articles/2203436.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Prestressed anchor cables are active reinforcement to improve slope stability. However, the anchoring is not a permanent guarantee of stability, and the slope retains a potential risk of instability. From the perspective of the internal force of anchor cables, a new early warning method for the safety of the slope is provided, and a slope analysis model is established. With the increase in the strength reduction factor, the internal force increment curves of anchor cables under different prestresses are obtained. The point corresponding to strength reduction factors λ1 and λ2 represents a warning point. Key conclusions are drawn as follows: (1) The internal force of an anchor cable can be used to judge the stability of the slope strengthened by a prestressed anchor cable. (2) A warning index based on the internal force increment ratio of anchor cables is established. (3) The internal force increment ratio of anchor cables eliminates the influence of the initial prestress and is convenient for engineering applications.
Źródło:
Archives of Civil Engineering; 2023, 69, 1; 553--569
1230-2945
Pojawia się w:
Archives of Civil Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
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