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Tytuł:
A methodology to estimate permeability in porous and fissured rock specimens at laboratory scale
Autorzy:
Estevez-Ventosa, Xian
Gonzalez-Molano, Nubia Aurora
Blazquez-Pascual, Vanesa
Alverellos, Jose
Alejano, Leandro R.
Powiązania:
https://bibliotekanauki.pl/articles/1853852.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
przepuszczalność
skała
test laboratoryjny
permeability
artificially jointed rock
lab tests
Opis:
The correct management of underground works, petroleum and gas reservoirs and geothermal appli-cations relies on the hydromechanical behaviour of rock masses. We describe a laboratory approach to measuring permeability for different types of rock specimens. A laboratory system was designed and set up using rock mechanics equipment (a servo-controlled hydraulic press, a Hoek cell, a pump for injecting water and a scale for measuring the volume of water flow). To verify the validity of the permeability measurements, tests were carried out on a reference porous rock (Corvio sandstone), with results showing good agreement with those published in the literature. Tests were subsequently carried out on artificially fissured granite specimens with different joint patterns, submitted to various confinement stresses up to 20 MPa. Results showed good agreement with traditional Klinkenberg test results. Other tests done with artificially fissured specimens are described for demonstrative purposes.
Źródło:
Archives of Mining Sciences; 2020, 65, 4; 821-833
0860-7001
Pojawia się w:
Archives of Mining Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A toy model of prebiotic peptide evolution: the possible role of relative amino acid abundances
Autorzy:
Polanco, Carlos
Buhse, Thomas
Samaniego, José
Castañón González, Jorge
Powiązania:
https://bibliotekanauki.pl/articles/1039570.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polarity index method.
computer simulation
prebiotic polymerization
toy model
peptides
amino acids
Opis:
This paper presents a mathematical-computational toy model based on the assumed dynamic principles of prebiotic peptide evolution. Starting from a pool of amino acid monomers, the model describes in a generalized manner the generation of peptides and their sequential information. The model integrates the intrinsic and dynamic key elements of the initiation of biopolymerization, such as the relative amino acid abundances and polarities, as well as the oligomer reversibility, i.e. fragmentation and recombination, and peptide self-replication. Our modeling results suggest that the relative amino acid abundances, as indicated by Miller-Urey type electric discharge experiments, played a principal role in the early sequential information of peptide profiles. Moreover, the computed profiles display an astonishing similarity to peptide profiles observed in so-called biological common ancestors found in the following three microorganisms; E. coli, M. jannaschii, and S. cereviasiae. The prebiotic peptide fingerprint was obtained by the so-called polarity index method that was earlier reported as a tool for the identification of cationic amphipathic antibacterial short peptides.
Źródło:
Acta Biochimica Polonica; 2013, 60, 2; 175-182
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ASSESSMENTS OF ANTIOXIDANT CONTENT AND THE ANTI-CARCINOGENIC EFFECT OF EXTRACTS OF SOLANUM ROSTRATUM DUNAL IN HUMAN CANCER CELLS
Autorzy:
Valadez Vega, María del Carmen
Izquierdo Vega, Jeannett Alejandra
Villagómez Ibarra, Jose Roberto
Sánchez Gutiérrez, Manuel
Madrigal Santillán, Eduardo Osiris
Morales Gonzalez, Jose Antonio
Bautista Ávila, Mirandeli
García Velasco, Laura
Powiązania:
https://bibliotekanauki.pl/articles/895384.pdf
Data publikacji:
2019-06-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
antioxidant
cytotoxic
Solanum rostratum
SiHa cell line
MDA cell line
Opis:
In Mexico, Solanum rostratum has been employed for the treatment of several diseases, including uterine cancer. The aim of this study was to evaluate the antioxidant and anti-carcinogenic activity of extracts of Solanum rostratum Dunal on MDA and SiHa cell lines. The methanolic, ethyl acetate, and hexane extracts of the aerial parts of Solanum rostratum were tested for phenols concentration, antioxidant activity, and anti-carcinogenic effect. The leaves extracts showed the highest content of phenols; however the flower-fruits extracts showed higher scavenging activity. On the other hand, ethyl acetate extracts exhibited the highest anti-carcinogenic effect, while methanolic extracts showed the least effect. The results of this work indicated that Solanum rostratum is a promising source of antioxidants, and the extracts exert a dose-dependent anti-carcinogenic effect on both cell lines.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 493-502
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Austerity policies in the Eurozone: How they affect youth unemployment?
Autorzy:
Díaz-Roldán, Carmen
Parada-Rodríguez, José Luis
Carmona-González, Nieves
Powiązania:
https://bibliotekanauki.pl/articles/14426269.pdf
Data publikacji:
2019-06-26
Wydawca:
Wyższa Szkoła Bankowa we Wrocławiu
Tematy:
Monetary unions
fiscal consolidation
sustainable policies
youth unemployment.
Opis:
Aim: Analyse the effects of stabilization policies on youth unemployment, using government deficit besides the use of fiscal policy by the supply side; aimed to characterize the economic framework conditions under which fiscal policy could reduce youth unemployment.   Design/Research methods: We consider an economic framework featuring the use of monetary and fiscal rules within a monetary union. In this scenario, that should be representative of the Eurozone, we will analyse the effects of stabilization policies when dealing with a financial crisis which produces contractive effects on output and on employment. We will pay special attention to the conservativeness of the central bank, the degree of austerity of the fiscal authorities and the initial level of government debt. Those characteristics prove to be crucial for the sustainability of economic policies packages based on fiscal consolidation and the use of fiscal policy instruments by the supply side, when trying to deal with unemployment. And given that in the financial crisis effects have been hit Eurozone countries in a different manner, we will also differentiate monetary union’s member countries according with their government debt and their unemployment path.   Conclusions/findings: Fiscal authorities should be no austere for fighting youth unemployment, when using fiscal policy by the supply side. In other words, when optimizing their loss function, they should give more weight to the output stabilization goal that to the government deficit reduction.  Originality/value of the article: Allowing for the use of both monetary and fiscal policy rules, in the scenario of a monetary union, our results could help us to stablish the conditions under which fiscal policy could help to alleviate youth unemployment.
Źródło:
Central European Review of Economics and Management; 2019, 3, 2; 7-20
2543-9472
Pojawia się w:
Central European Review of Economics and Management
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ayotzinapa. Entre la fragilidad institucional y la violencia del crimen organizado
Autorzy:
Ramirez, Gabino Solano
Brazan, Jose Carlos Luque
Gonzalez, Hortensia Gracida
Powiązania:
https://bibliotekanauki.pl/articles/683051.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Tematy:
Ayotzinapa
fragilidad institucional
violencia
grupos delictivos organizados
Guerrero
México
Opis:
El propósito de este trabajo es explorar las líneas comunicantes entre el acontecimiento denominado “Ayotzinapa” (ocurrido el 26 y 27 de septiembre en Iguala, Guerrero, donde 43 estudiantes de la Escuela Normal Rural de Ayotzinapa fueron desaparecidos), la inseguridad y violencia delincuencial asociada a la presencia de grupos delictivos organizados, y la fragilidad institucional de las estructuras de poder municipal para hacer frente a la amenaza que significan las organizaciones criminales en estados como Guerrero.Se argumenta que este suceso fue posible debido a las limitaciones del cambio político democrático en México, caracterizado como insuficiente y descompensado, sobre todo en las instituciones municipales, las cuales, paulatinamente, han cedido espacio a la creciente influencia de grupos delictivos organizados. ABSTRACTThe purpose of this paper is to explore the connecting lines between the event called “Ayotzinapa “ (which occurred on 26 and 27 September in Iguala, Guerrero, where 43 students of the Rural Normal School Ayotzinapa were missing), insecurity and criminal violence associated to the presence of organized criminal groups, and institutional fragility of the structures of municipal power to deal with the threat posed by criminal organizations in states like Guerrero.It is argued that this event was possible due to the limitations of democratic political change in Mexico, considered insufficient and unbalanced, especially in municipal institutions, which gradually have given way to the growing influence of organized criminal groups.
Źródło:
Anuario Latinoamericano – Ciencias Políticas y Relaciones Internacionales; 2016, 3
2449-8483
2392-0343
Pojawia się w:
Anuario Latinoamericano – Ciencias Políticas y Relaciones Internacionales
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Career plans of non-traditional students in the University of Seville
Plany zawodowe nietradycyjnych studentów Uniwersytetu w Sevilli
Autorzy:
Vazquez-Granadero, Maria
Tenorio-Rodriguez, Maria
Gonzalez-Monteagudo, Jose
Panilla-Carmona, Teresa
Powiązania:
https://bibliotekanauki.pl/articles/551464.pdf
Data publikacji:
2017
Wydawca:
Uczelnia Jana Wyżykowskiego
Tematy:
career plans
students
Erasmus+
EMPLOY
employability, higher education
plany zawodowe
studenci
szkolnictwo wyższe
zatrudnienie
Opis:
Zatrudnialność (employability) studentów i absolwentów stała się kluczowym celem w procesie bolońskim i polityce europejskiej w obszarze szkolnictwa wyższego. Mimo to badania dotyczące procesu wejścia absolwentów studiów wyższych na rynek pracy są niepełne. Szczególnie dotyczy to grupy nietradycyjnych studentów i absolwentów. Celem artykułu jest zaprezentowanie wyników badań dotyczących planów zawodowych nietradycyjnych studentów i społeczno-kulturowo-ekonomicznych uwarunkowań konstruowania ich ścieżki kariery po ukończeniu studiów wyższych. Artykuł opiera się na danych empirycznych zgromadzonych w ramach międzynarodowego projektu badawczego „EMPLOY. Enhancing the employability of non-traditional students in higher education”, finansowanego z programu Erasmus+, a także w ramach Szkolnictwa Wyższego, Partnerstwa Strategicznego 14-1-UK01-KA203-001842. W artykule wykorzystano wyniki interdyscyplinarnych badań jakościowych przeprowadzonych wśród nietradycyjnych studentów i absolwentów w Szwecji, Polsce, Wielkiej Brytanii, Irlandii, Portugalii, Hiszpanii. Celem badań projektu EMPLOY prowadzonych metodą biograficzną było: zrozumienie zatrudnialności (emploability) z perspektywy studentów/ absolwentów, pogłębienie wiedzy i zrozumienie czynników, które promują lub blokują zatrudnialność absolwentów (szczególnie nietradycyjnych) oraz zbadanie znaczenia czynników socjologicznych, jak wiek, płeć, klasa społeczna, etniczność, niepełnosprawność na perspektywę ich zatrudnienia (strona projektu: www.employ.dsw.edu.pl). Materiał badawczy prezentowany przez Autorów artykułu został zgromadzony na podstawie sześciu pogłębionych wywiadów biograficznych ze studentami (kobietami i mężczyznami) ostatniego roku studiów licencjackich na Uniwersytecie w Sevilli. Osoby badane reprezentowały różne kierunki studiów (sztuka, nauki humanistyczne, nauki przyrodnicze i techniczne) oraz posiadały jedną lub kilka cech charakterystycznych dla nietradycyjnego studenta. Badacze na podstawie analizy dostępnej literatury i badań wskazali na następujące kryteria nietradycyjności grupy badanej: wszyscy studenci należeli do pokolenia, które w swoich rodzinach było pierwszym uczestniczącym w kształceniu wyższym, połowa posiadała trudną sytuację ekonomiczną i ograniczone możliwości w budowaniu kapitału społeczno-kulturowego, dwoje badanych to osoby z niepełnosprawnością, jedna w wieku dojrzałym (adult student) i jedna z doświadczeniem migracji. Główne pytanie, wokół którego budowane były wypowiedzi biograficzne studentów, dotyczyło zatrudnialności oraz ich planów życiowych i zawodowych. Wyniki badań wskazują, że hiszpańscy studenci swoje plany zawodowe odkładają na później, tj. decydują się na kontynuowanie edukacji na studiach II stopnia (magisterskich). Wskazują na to nie tylko ich wypowiedzi, ale także prezentowany brak zainteresowania i zaangażowania w poszukiwanie pracy. Ich plany zawodowe są nieprecyzyjne, przepełnione wątpliwościami głównie z powodu niejasnej sytuacji społeczno-gospodarczej w kraju unijnym o najwyższym wskaźniku bezrobocia wśród młodych. Wyniki badań dowodzą, że studenci posiadają wiedzę (spoza uniwersytetu i jego jednostek) o możliwościach zatrudnienia i doskonale zaadaptowali się do sytuacji zewnętrznej, próbując w ten sposób opóźnić wejście na niepewny rynek pracy. Wszyscy natomiast planują także doskonalenie kompetencji językowych (szczególnie z języka angielskiego). Być może tę praktykę można wskazać jako strategię wzmacniania własnej zatrudnialności, aby zdobyć pracę poza granicami Hiszpanii lub w przedsiębiorstwach/ korporacjach/firmach, w których warunkiem przyjęcia do pracy jest posługiwanie się językiem obcym (szczególnie w sektorze turystycznym). Badani wskazują zewnętrzne i wewnętrzne bariery związane z zatrudnieniem. Do pierwszej grupy barier należą: brak pracy dla absolwentów na hiszpańskim rynku pracy oraz oczekiwania pracodawców poszukujących pracowników już z doświadczeniem zawodowym. Druga grupa barier związana jest z nietradycyjnymi cechami osób badanych, tj. niepełnosprawnością, innością, obcością kulturową.
Graduates’ employability has become a key objective in the Bologna process. There is little research, however, on the process of transition to the labor market of non-traditional groups. The aim of this paper is to study in more depth the career plans of nontraditional students, identifying what they will do when they finish their studies and how they plan to gain access to the labor market. The paper is placed within the context of the Erasmus+ European project EMPLOY (Enhancing the employability of non-traditional students in higher education, Erasmus Plus Program 2015-2017), qualitative, interdisciplinary and biographical research focusing on non-traditional university students and graduates from six European countries (Sweden, Poland, United Kingdom, Ireland, Portugal and Spain). The main project aims are to understand the employability from the perspective of students and graduates, increase knowledge and understanding of the factors that promote or hinder employability, and to explore the impact of age, gender, social class, ethnicity and disability in students’ employment prospects. Six biographical in-depth interviews have been carried out with students of the University of Seville (3 females, 3 males), all of them in the last year of their undergraduate program. They were selected on the basis of their degrees to represent different areas of knowledge (from Arts and Humanities to Science and Engineering), as well as on their specific characteristics of non-traditional students: adult and mature students (1), with a disability (2), immigrant (1), first generation (6), and learners with low economic and cultural capital (3). The interviews started with the whole picture of the personal and educational background of the participants, and then focused on their employability and career plans. The results show that for all participants the next step to take once they finish their current degree is to go on studying. Instead of searching for a job in the short-term, they plan to continue their university education, mostly through a masters degree, but also by improving their level of English. The strategies and action they plan to implement are surprisingly vague and imprecise, as they prioritise education instead of searching for and finding a job. In addition, they have neither information about nor previous experience with, the existing career services, which again means that they are not in active search of employment. Discussion focuses on the idea that these findings are related to the obstacles they perceive they will encounter in the near future. Hence, the general perception is that there are no opportunities in the labor market for them. It is not a problem of being more “employable” or having better competences when searching for employment, but the simple matter of opportunities in the current Spanish market. Additionally, they mention another barrier: employers usually search for people with previous work experience and they lack it, so they will have to pass through an uncertain process of acquiring this experience before having real opportunities. A special mention must be made for students with disabilities because they highlighted the personal barriers deriving from their own disability that could hinder their professional development.
Źródło:
Społeczności Lokalne. Studia Interdyscyplinarne; 2017, 1; rb.ujw.pl/local
2544-5545
Pojawia się w:
Społeczności Lokalne. Studia Interdyscyplinarne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of a possible uptake mechanism of selective antibacterial peptides
Autorzy:
Polanco, Carlos
Samaniego, José
Castañón-González, Jorge
Buhse, Thomas
Sordo, Marili
Powiązania:
https://bibliotekanauki.pl/articles/1039457.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Polarity index method
cell penetrating peptides
selective antibacterial peptides
Opis:
Selective antibacterial peptides containing less than 30 amino acid residues, cationic, with amphipathic properties, have been the subject of several studies due to their active participation and beneficial effects in strengthening the immune system of all living organisms. This manuscript reports the results of a comparison between the group of selective antibacterial peptides and another group called "cell penetrating peptides". An important number of the selective antibacterial peptides are cell penetrating peptides, suggesting that their toxicity is related to their uptake mechanism. The verification of this observation also includes the adaptation of a method previously published, called Polarity index, which reproduces and confirms the action of this new set of peptides. The efficiency of this method was verified based on four different databases, yielding a high score. The verification was based exclusively on the peptides already reported in the databases which have been experimentally verified.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 629-633
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of Catechins from Smilax domingensis Willd. in Cuba
Autorzy:
Soledispa, Pilar A.
González, José
Cuéllar, Armando
Pérez, Julio
Monan, Max
Powiązania:
https://bibliotekanauki.pl/articles/1077467.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
GC/MS
Smilax domingensis
catechins
ethanolic extract
flavanols
Opis:
Gas Chromatography coupled with mass spectrometry was applied to study the fragmentation of selected flavonoids from the ethanolic extract of Smilax domingensis Willd., Smilacaceae, known as zarzaparrilla, after Soxhlet extraction during 20 hours. Compounds belonging to one of the major subgroups found in common plants, i.e. flavanols were studied. Following solvent extraction and derivatization using BSTFA, possibly two different metabolites from the same chemical group were characterized in one analytical run: (+)-catechin and (-)-epicatechin. For the very first time, qualitative data on these analytes in the drug were determined after detailed validation of a sensitive, cheap and reliable GC-MS method.
Źródło:
World News of Natural Sciences; 2019, 23; 297-305
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chemical characterization by TLC, UV, IR, HPLC-MS/MS and NMR of gossypetin-3’-O-glucoside from Talipariti elatum (Sw.) Malvaceae
Autorzy:
González, José
Cuéllar, Armando
Gaysinski, Marc
Massi, Lionel
Monan, Max
Nossin, Enmanuel
François-Haugrin, Frantz
Powiązania:
https://bibliotekanauki.pl/articles/1076714.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
IR
MS
NMR
TLC
Talipariti elatum
UV
flavonoids
Opis:
Talipariti elatum (Sw.) Malvaceae, also known as Blue Mahoe or Mountain Mahoe, commonly named as Majagua azul or Majagua, with red or crimson flowers, is a medicinal tree traditionally used against cough, asthma, catarrh, and expectorant. Its flowers contain a lot different chemical compounds, mainly flavonoids. From red petals of the flowers a flavonol glucoside was isolated and characterized by TLC, UV, IR, HPLC-MS/MS and NMR spectroscopy. Structure analyses of that chemical component revealed that It have the identical glucoside moiety attached to a flavonol skeleton like gossypitrin (gossypetin-7-O--glucoside) but in different position for which the structure of gossypetin-3’-O-glucoside was deduced from HSQC, HMBC, COSY and NOESY correlations.
Źródło:
World News of Natural Sciences; 2019, 24; 100-116
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chernobyl Liquidators - the people and the doses
Autorzy:
Gan-Jose, Luis K.
Gonzalez-Kimena, Virginia
Powiązania:
https://bibliotekanauki.pl/articles/1121328.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Chernobyl liquidators
the doses
the people
Opis:
The clean-up operations following the Chernobyl accident were arguably the greatest in the history of mankind. This paper is not intended to give a comprehensive review of the Chernobyl related research, we present only a review of the scientific literature available till now about the “liquidators”, i.e. people who performed the task of decontamination work near the damaged Chernobyl nuclear power plant. Most of the approximately 300,000 liquidators who took part in the mitigation of the local consequences of the Chernobyl accident between 1986 and 1989 received only low radiation doses which are comparable or lower than those documented in nuclear worker registries. The health consequences from these radiation doses are too small to be identifiable in any epidemiological study that does not target specific sub-groups with potentially higher exposure. From our review of the published literature, several criteria are derived which could be used to identify potentially suitable sub-populations; in particular, among those being the liquidators who participated in the clean-up work during in 1986, including CNPP staff, special groups such as the “sarcophagus workers” (39), helicopter crews (3, 48), liquidators from the Institute of Biophysics who had participated in clean-up work in Chernobyl (12, 20), the Samoilenko group (12), sarcophagus builders (12) and groups other that the aforementioned.
Źródło:
World News of Natural Sciences; 2016, 4; 44-60
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Computational model of abiogenic amino acid condensation to obtain a polar amino acid profile
Autorzy:
Polanco, Carlos
Buhse, Thomas
Samaniego, José
Castañón González, Jorge
Estrada, Miguel
Powiązania:
https://bibliotekanauki.pl/articles/1039283.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
amino acids
proteinoids
origins of life
polarity
computer simulations
Opis:
In accordance with the second law of thermodynamics, the Universe as a whole tends to higher entropy. However, the sequence of far-from-equilibrium events that led to the emergence of life on Earth could have imposed order and complexity during the course of chemical reactions in the so-called primordial soup of life. Hence, we may expect to find characteristic profiles or biases in the prebiotic product mixtures, as for instance among the first amino acids. Seeking to shed light on this hypothesis, we have designed a high performance computer program that simulates the spontaneous formation of the amino acid monomers in closed environments. The program was designed in reference to a prebiotic scenario proposed by Sydney W. Fox. The amino acid abundances and their polarities as the two principal biases were also taken into consideration. We regarded the computational model as exhaustive since 200 000 amino acid dimers were formed by simulation, subsequently expressed in a vector and compared with the corresponding amino acid dimers that were experimentally obtained by Fox. We found a very high similarity between the experimental results and our simulations.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 253-258
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of selective antibacterial peptides by the Polarity Profile method
Autorzy:
Polanco, Carlos
Buhse, Thomas
Samaniego, José
Castañón-González, Jorge
Powiązania:
https://bibliotekanauki.pl/articles/1039571.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
selective cationic amphipathic antibacterial peptides
Polarity Profile method
Polarity Index method
Opis:
Antimicrobial peptides occupy a prominent place in the production of pharmaceuticals, because of their effective contribution to the protection of the immune system against almost all types of pathogens. These peptides are thoroughly studied by computational methods designed to shed light on their main functions. In this paper, we propose a computational approach, named the Polarity Profile method that represents an improvement to the former Polarity Index method. The Polarity Profile method is very effective in detecting the subgroup of antibacterial peptides called selective cationic amphipathic antibacterial peptides (SCAAP) that show high toxicity towards bacterial membranes and exhibit almost zero toxicity towards mammalian cells. Our study was restricted to the peptides listed in the antimicrobial peptides database (APD2) of December 19, 2012. Performance of the Polarity Profile method is demonstrated through a comparison to the former Polarity Index method by using the same sets of peptides. The efficiency of the Polarity Profile method exceeds 85% taking into account the false positive and/or false negative peptides.
Źródło:
Acta Biochimica Polonica; 2013, 60, 2; 183-189
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Discrete dynamic system oriented on the formation of prebiotic dipeptides from Rodes experiment
Autorzy:
Polanco, Carlos
Samaniego, José
Buhse, Thomas
Castañón González, Jorge
Powiązania:
https://bibliotekanauki.pl/articles/1039201.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
origins of life
biogenesis
dipeptides
salt-induced peptide formation
Opis:
This work attempts to rationalize the possible prebiotic profile of the first dipeptides of about 4 billion years ago based on a computational discrete dynamic system that uses the final yields of the dipeptides obtained in Rode's experiments of salt-induced peptide formation (Rode et al., 1999, Peptides 20: 773-786). The system built a prebiotic scenario that allowed us to observe that (i) the primordial peptide generation was strongly affected by the abundances of the amino acid monomers, (ii) small variations in the concentration of the monomers have almost no effect on the final distribution pattern of the dipeptides and (iii) the most plausible chemical reaction of prebiotic peptide bond formation can be linked to Rode's hypothesis of a salt-induced scenario. The results of our computational simulations were related to former simulations of the Miller, and Fox & Harada experiments on amino acid monomer and oligomer generation, respectively, offering additional information to our approach.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 717-726
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electronegativity and intrinsic disorder of preeclampsia-related proteins
Autorzy:
Polanco, Carlos
Castañón-González, Jorge
Uversky, Vladimir
Buhse, Thomas
Samaniego Mendoza, José
Calva, Juan
Powiązania:
https://bibliotekanauki.pl/articles/1038693.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
preeclampsia
intrinsically disordered proteins
structural proteomics
bioinformatics
antimicrobial peptides
polarity index method
lipoproteins
angiogenesis proteins
Opis:
Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study which evaluated the commonness and potential functionality of intrinsic disorder of these proteins and also made an attempt to characterize their origin. The origin of the preeclampsia-related proteins was assessed with a supervised technique, a Polarity Index Method (PIM), which evaluates the electronegativity of proteins based solely on their sequence. The commonness of intrinsic disorder was evaluated using several disorder predictors from the PONDR family, the charge-hydropathy plot (CH-plot) and cumulative distribution function (CDF) analyses, and using the MobiDB web-based tool, whereas potential functionality of intrinsic disorder was studied with the D2P2 resource and ANCHOR predictor of disorder-based binding sites, and the STRING tool was used to build the interactivity networks of the preeclampsia-related proteins. Peculiarities of the PIM-derived polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, and the intrinsically disordered proteins. Our results showed a high graphical correlation between preeclampsia proteins, lipoproteins, and the angiogenesis proteins. We also showed that many preeclampsia-related proteins contain numerous functional disordered regions. Therefore, these bioinformatics results led us to assume that the preeclampsia proteins are highly associated with the lipoproteins group, and that some preeclampsia-related proteins contain significant amounts of functional disorders.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 99-111
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental approach towards the water contact angle value on the biomaterial alloy Ti6Al4V
Autorzy:
Margarita Hierro-Oliva, Margarita
Gallardo-Moreno, Amparo Maria
Rodríguez-Cano, Abraham
Bruque, Jose Morales
González-Martínb, Maria Luisa
Powiązania:
https://bibliotekanauki.pl/articles/764085.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Opis:
In the biomedical field, water contact angle is a useful gauge to follow how a biomaterial surface would interact with the surrounding water-like physiological environment. Ti6Al4V alloy is widely used in orthopedic applications. Nevertheless, the values of its water contact angle reported in the literature show a large dispersion, from 40° up 80°. However, in addition to the expected dependence of the surface wettability on preliminary treatments, the values of the water contact angle on the pristine Ti6Al4V alloy suffers from an important variability and lack of reproducibility.The present research pays attention to this difficulty and proposes a simple experimental procedure to ensure adequate contact angle reproducibility. Controlled passivation growth in mild underwater conditions of freshly polished disks, followed by ultrasonic washing, avoiding the rubbing of the surface, gives average water contact angles of 80° with very low standard deviations also among samples from the same batch.
Źródło:
Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia; 2015, 70, 1
2083-358X
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 40

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