Autor: Gajecki, M. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Skąd się biorą mikotoksykozy u bydła
Where from cattle’s mycotoxicosis get
Autorzy:: Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/125.pdf
Data publikacji:: 2013
Wydawca:: Instytut Innowacji Przemysłu Mleczarskiego
Opis:: Wieloskładnikowa dawka żywieniowa przeżuwaczy, składająca się z paszy treściwej i objętościowej, może być źródłem bardzo różnych mikotoksyn, które zanieczyszczają poszczególne składniki pasz. Spory odsetek mikotoksyn jest skutecznie inaktywowany w żwaczu, podczas gdy inne przechodzą bez zmian lub powstają metabolity, które zachowują aktywność biologiczną. Stąd aktywność bariery żwacza, w dużej mierze determinuje podatność wobec mikotoksyn krów mlecznych i innych gatunków przeżuwaczy. Osłabienie tej funkcji, spowodowanej stanami chorobowymi lub bezpośredniego działania przeciwbakteryjnego niektórych mikotoksyn, może zwiększyć wskaźnik absorpcji mikotoksyn. Szybkość wchłaniania nie zależy wyłącznie od ilości pobranych mikotoksyn i ryzyka wystąpienia niepożądanych skutków zdrowotnych, ale także od stopnia wydalanie mikotoksyn i biologicznej aktywnych ich metabolitów np. w mleku.
The complex diet of ruminants, consisting of forages, concentrates, and preserved feeds, can be a source of very diverse mycotoxins that contaminate individual feed components. A number of mycotoxins are successfully inactivated by the rumen flora, whereas others pass unchanged or are converted into metabolites that retain biological activity. Hence, the barrier function of the rumen largely determines the susceptibility of dairy cows and other ruminant species towards individual mycotoxins. An impairment of this barrier function due to diseases or the direct antimicrobial effect of certain mycotoxins may increase absorption rates. The rate of absorption deter-mines not only the internal dose and risk for adverse health effects, but also the excretion of mycotoxins and the biologically active metabolites into milk.
Źródło:: Innowacyjne Mleczarstwo; 2013, 01, 1
2353-1282
Pojawia się w:: Innowacyjne Mleczarstwo
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Czy mikotoksyny mogą być substancjami hamującymi w mleku?
Is mycotoxins can be used as inhibitors in milk?
Autorzy:: Gajecka, M.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/117.pdf
Data publikacji:: 2014
Wydawca:: Instytut Innowacji Przemysłu Mleczarskiego
Tematy:: mleko krowie
krowy mleczne
zywienie zwierzat
lancuch paszowy
zanieczyszczenia pasz
zanieczyszczenia mikrobiologiczne
mikotoksyny
fumonizyny
zdrowotnosc zwierzat
Opis:: Zwierzęta mogą być narażone na działanie mikotoksyn w łańcuchu paszowym. Miko-toksyny występują głównie, jako zanieczyszczenia w paszy i mogą być wydalane w płynach biologicznych, takich jak mocz lub w mleku zwierząt lub ludzi, jako substancja macierzysta lub jako metabolit. Wiele prób dotyczących obecności mikotoksyn zostało przeprowadzonych na całym świecie i z badań tych wynika, że ma miejsce współwy-stępowanie mikotoksyn w materiałach paszowych i żywności. W rzeczywistości, wyni-ki sugerują, że w pewnych sytuacjach nawet 50% produktów mleczarskich może być zanieczyszczone przez mikotoksyny. Jednak opierając się na danych analitycznych w celu określenia stopnia ekspozycji mikotoksynami zwierząt i ludzi wyniki są słabo obiecujące ze względu na niejednorodny rozkład mikotoksyn w materiałach paszo-wych i produktach spożywczych, odstępu czasu pomiędzy pobraniem mikotoksyn, rozwojem choroby przewlekłej i niedokładności dietetycznych podczas określania danych w paszy i żywności. Jednak w porównaniu do innych płynów ustrojowych, takich jak krew, osocze czy mocz, to poziom wielu mikotoksyn w mleku zwierząt i ludzi jest raczej mały. Mleko matki jest istotnym źródłem mikotoksyn dla noworod-ków zwierząt i ludzi, ponieważ ich obecność została udokumentowana w próbkach pobranych w kilku krajach europejskich. Dlatego obecność mikotoksyny w mleku krów może być ważnym i poważnym problemem.
Animals can be exposed to mycotoxins through the feed chain. Mycotoxins are mainly found as contaminants in feed and could be subsequently excreted via biological fluids such as urine or animal breast milk in native or metabolized form. Many attempts to study the occurrence of mycotoxins have been carried out around the world and these surveys have commonly demonstrated the co-occurrence of mycotoxins in feed mate-rials and food. In fact, results suggest that in certain situations as much as 50% of the dairy products may be contaminated by mycotoxins. However, relying on analytical data for determining mycotoxin exposure of animal and human populations is difficult due to the heterogeneous distribution of mycotoxins in feed materials and food com-modities, the time lag between toxin intake and the development of chronic disease and the inaccuracies of dietary for determining feed and food intake data. Yet, in com-parison to other biological fluids such as blood, plasma and urine, the database on multi-mycotoxin levels in animal and human milk is rather small. Breast milk is a re-levant source of mycotoxins for animal and human neonates since their presence in samples collected in several European countries has been documented. Therefore, the presence of mycotoxins in cow's milk could be a important and serious problem.
Źródło:: Innowacyjne Mleczarstwo; 2014, 02, 1
2353-1282
Pojawia się w:: Innowacyjne Mleczarstwo
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Text summarizing in Polish
Streszczanie tekstu w języku polskim
Autorzy:: Branny, E.
Gajęcki, M.
Powiązania:: https://bibliotekanauki.pl/articles/305824.pdf
Data publikacji:: 2005
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:: przetwarzanie języka naturalnego
streszczanie tekstu
natural language processing
text summarizing
Opis:: The aim of this article is to describe an existing implementation of a text summarizer for Polish, to analyze the results and propose the possibilities of further development. The problem of text summarizing has been already addressed by science but until now there has been no implementation designed for Polish. The implemented algorithm is based on existing developments in the field but it also includes some improvements. It has been optimized for newspaper texts ranging from approx. 10 to 50 sentences. Evaluation has shown that it works better than known generic summarization tools when applied to Polish.
Celem artykułu jest zaprezentowanie algorytmu streszczającego teksty w języku polskim. Mimo istnienia algorytmów streszczających teksty, brak jest algorytmów dedykowanych dla języka polskiego. Przedstawiony algorytm bazuje na istniejących algorytmach streszczania tekstu, ale zawiera kilka ulepszeń. Algorytm jest przeznaczony dla streszczania tekstów prasowych liczących od 10 do 50 zdań. Przeprowadzone testy pokazują, że algorytm działa lepiej od znanych algorytmów zastosowanych dla języka polskiego.
Źródło:: Computer Science; 2005, 7; 31-48
1508-2806
2300-7036
Pojawia się w:: Computer Science
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: The effects of dietary deoxynivalenol (DON) on selected blood biochemical and hematological parameters in pre-pubertal gilts
Autorzy:: Zielonka, L.
Gajecka, M.
Tarasiuk, M.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/2087992.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: The aim of this study was to determine whether exposure to low doses of DON leads to changes in serum hematological and biochemical profiles. In the experiment, pre-pubertal gilts (with body weight of up to 25 kg) were administered DON per os at a daily dose of 12 |ig/kg BW (group E, n=18) or a placebo (group C, n=21) over a period of 42 days. Blood for analysis was sampled seven times at weekly intervals. Minor, but statistically significant changes were observed in selected indicators, particularly in weeks 2 and 3 in values of biochemical parameters such AlAT, AspAT, Pin and Fe, and in values of hematological parameters such as RBC, MCV, MCHC, PLT, MPV, WBC, neutrophil, eosinophil, lymphocyte and monocyte counts. In group E, a decreasing trend of the values was observed in most cases, except for RBC, PLT, eosinophil, lymphocyte and monocyte counts. Similar results were obtained in the last two weeks of the experiment. Initially, exposure to DON has a stimulating effect, which is eliminated when adaptive mechanisms are triggered. The results of the study indicate that the intensity of biotransformation processes varies subjected to the body's energy resources.
Źródło:: Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: The effect of selected environmental Fusarium mycotoxins on the ovaries in the female wild boar (Sus scrofa)
Autorzy:: Zielonka, L.
Gajecka, M.
Zmudzki, J.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/31466.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: The contamination of agricultural crops with Fusarium mycotoxins poses one of the greatest problems in food production. Wild boars live in specific habitats and are physiologically sensitive to Fusarium mycotoxins, therefore, they are an interesting model for studies investigating the effects of the discussed toxin, in particular under low-dose exposure. The objective of this study was to determine potential effects of Fusarium mycotoxins ingested with naturally contaminated food on reproductive function based on the proliferation and apoptotic indices of ovarian follicles in female wild boars. The experiment was conducted on 40 wild boars inhabiting north-eastern Poland. The effect of seasonal variations in the quantity and quality of ingested food on the concentrations of Fusarium mycotoxins and their metabolites in the blood of wild boars was analyzed. The observed differences in toxin levels were accompanied by changes in proliferation and apoptotic indices. Proliferation processes were most intense in autumn-winter and were least advanced in winter-spring. The intensity of apoptotic processes was inversely correlated with proliferation.
Źródło:: Polish Journal of Veterinary Sciences; 2015, 18, 2
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Multi-mycotoxicosis
Autorzy:: Gajęcki, M.
Zielonka, Ł.
Obremski, K.
Jakimiuk, E.
Gajęcka, M.
Powiązania:: https://bibliotekanauki.pl/articles/363270.pdf
Data publikacji:: 2007
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:: antagonizm
pasza
mykotoksyna
synergizm
antagonism
feed materials
mycotoxicosis
synergism
Opis:: Contamination of food and feeds with mycotoxins is a major problem of human and animal's health concern, and it is also extremely detrimental to economy. Mycotoxin-producing moulds may produce the most known mycotoxins, such as aflatoxins, ochratoxin, trichothecenes, zearalenone and fumonisin. Although toxicological, environmental and epidemiological studies have addressed the problem of these toxins one by one, more than one mycotoxin is found usually in the same contaminated commodities. That raises the incommensurable problem of multi-mycotoxicosis in which the respective metabolites are also involved. These mycotoxins bear potential toxicity leading to acute and chronic effects in humans and animals, depending on species. The mechanisms that lead to toxic effects, such as immune toxicity and carcinogenicity, are complex. The risk assessment for humans potentially exposed to multi-mycotoxins suffers very much from the lack of adequate food consumption data. Furthermore, for a given mycotoxin additive, synergism and antagonism with other mycotoxins found in the same food commodities are usually not taken into account.
Źródło:: Environmental Biotechnology; 2007, 3, 1; 25-29
1734-4964
Pojawia się w:: Environmental Biotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Immunohistochemical evaluation of apoptosis and proliferation in the mucous membrane of selected uterine regions in pre - pubertal bitches exposed to low doses of zearalenone
Autorzy:: Stopa, E.
Babinska, I.
Zielonka, L.
Gajecki, M.
Gajecka, M.
Powiązania:: https://bibliotekanauki.pl/articles/30158.pdf
Data publikacji:: 2016
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Mycotoxins are toxic secondary metabolites produced by fungi. Those biologically active compounds occur naturally and they include zearalenone (ZEN), a mycotoxin that contaminates plant material, including the ingredients used in the production of commercial dog food. The influence of monotonic, low-dose and long-term exposure to ZEN on pre-pubertal bitches has not been fully explored to date. This paper describes a 42-day experiment performed on clinically healthy female dogs aged approximately 70 days, with estimated body weight of 8 kg. The animals were randomly divided into two experimental groups (EI and EII) and a control group (C) of 10 animals each. Group EI received 50 μg ZEN/kg (of body weight) per os, group EII received 75 μg ZEN/kg BW per os, and the control group was administered placebo. The bitches were ovariohysterectomized at the end of the experiment (at around 112 days of age), and selected sections of the uterine wall were subjected to immunohistochemical analyses (TUNEL and PCNA). A shift towards higher apoptotic (AI) and proliferative index (PI) was observed, in particular in group EI. Higher AI and PI values were noted in the epithelium of all uterine regions analysed and in the uterine glands in the uterine horn proximal to the body of the uterus.
Źródło:: Polish Journal of Veterinary Sciences; 2016, 19, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: The effect of exogenous proteases on selected hematological and serum biochemical parameters in boars
Autorzy:: Zielonka, L
Przewoski, W.
Gajecka, M.
Jakimiuk, E.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/32369.pdf
Data publikacji:: 2010
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: boar
farm animal
pig
enzymatic complex
enzymatic growth promoter
hematological parameter
serum
biochemical parameter
proteolytic enzyme
physiological norm
nitrogen metabolism
Opis:: The increasing interest in enzymatic growth promoters prompted this investigation of the effect of an enzymatic stimulating complex on selected hematological and serum biochemical parameters in boars. The enzymatic complex [five proteases (proteinases-endopeptidases) and two peptidases (exopeptidases) obtained by fermentation from Streptomyces fradiae] was added to diets for three months, at initial doses of 90 (group El) and 120 (group E2) g/ton feed for the first seven days followed by 40 and 60 g/ton, respectively, in the subsequent weeks. The evaluation was based on selected hematological (RBC, WBC, HCT (Ht), HGB (Hb), MCV, MCH, and MCHC) and biochemical (AST, ALT, AP, Ca, Mg, urea, cholesterol, creatinine, inorganic phosphorus, and oxyglucose) parameters determined before and after the experimental period. The reported values were within physiological norms. Statistical differences were found between experimental groups with respect to WBC, HCT (Ht), MCV, MCH, AP, Ca, Mg, creatinine, and inorganic phosphorus. The study results indicate that the complex of proteolytic enzymes administered to boars caused no negative changes in their metabolic profiles. The statistically different hematological and serum biochemical parameters, while within normal limits, point to an early stage of microcytic anemia and heightened agitation that could be the result of intensified nitrogen metabolism.
Źródło:: Polish Journal of Veterinary Sciences; 2010, 13, 1; 151-156
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Zearalenone and deoxynivalenol mycotoxicosis in dairy cattle herds
Autorzy:: Marczuk, J.
Obremski, K.
Lutnicki, K.
Gajecka, M.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/30407.pdf
Data publikacji:: 2012
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Mycotoxin contaminations pose a growing problem in animal production from the economic and toxicological point of view. Clinical symptoms of mycotoxicosis are relatively unspecific, making the disease difficult to diagnose. This study presents a clinical case of dairy cattle infected with natural mycotoxins produced by fungi of the genus Fusarium (zearalenone [ZEA] and deoxynivalenol [DON]) in eastern Poland. In dead and infected cows, the presence of ZEA and DON was determined in the blood serum, significant changes were observed in blood morphological and biochemical profiles, extravasations and bowel inflammations were also observed. The results reported testify to an acute autoimmune process in the intestines as well as immunosuppression.
Źródło:: Polish Journal of Veterinary Sciences; 2012, 15, 2
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Effect of deoxynivalenol on the levels of toll-like receptors 2 and 9 and their mRNA expression in enterocytes in the porcine large intestine: a preliminary study
Autorzy:: Dabrowski, M.
Jakimiuk, E.
Gajecka, M.
Gajecki, M.T.
Zielonka, L.
Powiązania:: https://bibliotekanauki.pl/articles/32154.pdf
Data publikacji:: 2017
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Deoxynivalenol (DON), one of the most prevalent mycotoxins in the world, and is capable of inducing immune disorders in humans and animals. The aim of this study was to determine the effect of feed contaminated with DON on the number of TLR2- and TLR9-positive cells and their mRNA expression in the porcine large intestine. The experiment was conducted on two equal groups of pigs (n=4). The experimental group (E) was administered feed contaminated with DON (1008 μg/kg of feed) for 6 weeks, and the control group (C) was administered non-contaminated feed over the same period of time. A decrease in the expression of TLR2 mRNA was noted in the cecum. The percentage of TLR9-positive enterocytes increased in the ascending colon and decreased in the cecum. The results of this study indicate that DON can modify the local immune response by changing the expression of TLRs.
Źródło:: Polish Journal of Veterinary Sciences; 2017, 20, 2
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Cecal enzyme activity in gilts following experimentally induced Fusarium mycotoxicosis
Autorzy:: Slizewska, K.
Nowak, A.
Piotrowska, M.
Zakowska, Z.
Gajecka, M.
Zielonka, L.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/2087975.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: The objective of the presented study was to examine the influence of Fusarium mycotoxins (zearalenone - ZEN and deoxynivalenol - DON), administered separately and in combination, on the activity of cecal enzymes (ß-glucosidase and ß-glucuronidase) in gilts which were fed fodder contaminated with these mycotoxins. The activity of ß-glucosidase and ß-glucuronidase varied in the range of 0.170-1.236 μmol • h-1 • mg-1 and 8.701-96.704 μmol • h-1 • mg-1, respectively. In the first two weeks, the toxins had no significant effect on the activity of ß-glucosidase and ß-glucuronidase in the ascending and descending colon. After week 3 and later on, ZEN and DON administered as a mixture led to the highest increase in the activity of both enzymes. Administered separately, DON affected the activity of enzymes more than ZEN. From the third week of the experiment, an increase in the activity of CW ß-glucosidase and ß-glucuronidase was observed.
Źródło:: Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Evaluation of selected serum biochemical and haematological parameters in gilts exposed per os to 100 ppb of zearalenone
Autorzy:: Jakimiuk, E.
Radwinska, J.
Pomianowski, A.
Wozny, M.
Obremski, K.
Gajecka, M.
Brzuzan, P.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/30098.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: Zearalenone (ZEN) widely contaminates animal feed of plant origin. The recommended safe concentrations of ZEN in feeds for various animal species are set mainly based on the mycotoxin’s hormonal properties (NOEL). Our growing knowledge about biologically active concentrations of ZEN, molecular mechanisms and cells/tissues targeted by ZEN indicates that the harmful effects exerted by this mycotoxin on animals may be far greater than previously believed. This experiment was performed on pre-pubertal gilts divided into a control group (n=9) and an experimental group (ZEN, n=9). The control group received placebo, whereas the experimental group was administered ZEN at a dose of 0.1 mg/kg feed (equivalent to 5 μg/kg BW/day) for 42 days. On days 14, 28 and 42 blood samples were collected from the animals to determine the concentrations of selected zearalenols, serum biochemical and haematological parameters. Conjugated ZEN was found in the blood serum of the experimental gilts. Changes in the analysed biochemical parameters included a transient increase in albumin and cholesterol levels. A statistically significant increase in the concentrations of neutrophilic and acidophilic granulocytes was observed in the white blood cell system. The results indicate that long-term per os exposure of pre-pubertal gilts to low doses of ZEN (below NOEL) has a modulatory effect on liver function and white blood cells.
Źródło:: Polish Journal of Veterinary Sciences; 2015, 18, 4
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Dichlorodiphenyldichloroethylene (DDE) residue limit exceeded in pig tissues after feed-borne exposure to maximum allowed concentration
Autorzy:: Woźny, M.
Jakimiuk, E.
Brzuzan, P.
Florczyk, M.
Newiadowska, A.
Obremski, K.
Gajęcka, M.
Młynarczuk, J.
Gajęcki, M.
Powiązania:: https://bibliotekanauki.pl/articles/363198.pdf
Data publikacji:: 2015
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:: body burden
organochlorine pesticides
pig
residue
świnia
pestycydy chloroorganiczne
biostężenie
pozostałość
Opis:: Monitoring of undesirable substances by the European Union indicates a presence of natural and anthropogenic pollutants in animal feed that may be of concern for the producers, as well as the veterinary services. Although the literature concerning toxicity of DDT (an insecticide widely used in the past) is extensive, less attention has been focused on the biological properties of DDE and its interactions with other contaminants. This study reports on the concentration profile of p,p’-DDE and two other ogranochlorines (p,p’-DDT, p,p’-DDD) in different tissues of immature gilts after 14, 28, and 42 days of oral exposure to p,p’-DDE alone (0.5mg·kg-1feed·day-1) and in mixture with naturally occurring mycotoxin zearalenone, ZEN (0.5+0.1mg·kg-1feed·day-1). The treatment resulted in a time-dependent accumulation of p,p’-DDE in fat-rich tissues. Although the pesticide’s concentration found in the adipose tissue exceeded the FAO/WHO maximum residue limit (5mg·kg-1 of fat), human dietary risk is little, as it requires a substantial consumption of such contaminated pork fat. Importantly, the high concentration of p,p’-DDE found in the adrenal glands suggests a threat to the animals’ health. Finally, a difference in the accumulation of p,p’-DDE was observed between the groups treated with this compound alone or in mixture with ZEN. This is most likely related to growth performance of the animals, altered by the endocrine disrupting activity of both compounds. Further research should evaluate the effects of p,p-DDE at the observed concentrations on the pigs’ health status and enable the studies of possible interactions with other environmental pollutants.
Źródło:: Environmental Biotechnology; 2015, 11, 1; 1-9
1734-4964
Pojawia się w:: Environmental Biotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: MicroRNA expression profiles in liver and colon of sexually immature gilts after exposure to Fusarium mycotoxins
Autorzy:: Brzuzan, P.
Wozny, M.
Wolinska-Niziol, L.
Piasecka, A.
Florczyk, M.
Jakimiuk, E.
Gora, M.
Luczynski, M.K.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/2087983.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: To improve our knowledge of the role of microRNAs (miRs) in responses of the porcine digestive system to two Fusarium mycotoxins, zearalenone (ZEN) and deoxynivalenol (DON), we examined the expression of 7 miRs (miR-9, miR-15a, miR-21, miR-34a, miR-122, miR-125b, and miR-192), previously found to be deregulated in diseased liver and colon cells. In this study, immature gilts were exposed to NOEL doses of ZEN (40 |ig/kg/d), DON (12 |ig/kg/d), ZEN+DON (40 + 12 |ig/kg/d), and placebo (negative control group) for 7,14, 21, 28, 35, and 42 days. Before the treatment, expression levels of the selected miRs were measured in the liver, the duodenum, the jejunum, and the ascending and the descending colon of the gilts. Hierarchical clustering of the tissues by their miR expression profiles was consistent with what would be expected based on the anatomical locations and the physiological functions of the organs, suggesting that functions of the miRs are related to the specificities of the tissues in which they are expressed. A subset of 2 pairs of miRs (miR-21+miR-192 and miR-15a+miR-34a), which were assigned to two distinct clusters based on their tissue abundance, was then evaluated in the liver and the ascending and the descending colon during the treatment. The most meaningful results were obtained from the ascending colon, where a significant effect of the treatment was observed, suggesting that during the exposure to mycotoxins, the pathways involved in cell proliferation and survival were disordered. Changes in miR expression in the liver and the descending colon of the treated gilts were smaller, and were associated more with treatment duration than the exposure to ZEN, DON, or ZEN+DON. Further research should focus on identification of genes whose expression is regulated by these aberrantly expressed miRs. This should facilitate understanding of the miRNA-regulated biological effects of mycotoxins.
Źródło:: Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Tytuł:: The effect of T-2 toxin on percentages of CD4plus, CD8plus, CD4plusCD8plus and CD21plus lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches
Autorzy:: Obremski, K.
Podlasz, P.
Zmigrodzka, M.
Winnicka, A.
Wozny, M.
Brzuzan, P.
Jakimiuk, E.
Wojtacha, P.
Gajecka, M.
Zielonka, L.
Gajecki, M.
Powiązania:: https://bibliotekanauki.pl/articles/30985.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: The immune system is one of the main toxicity targets of the T-2 toxin. In view of scant research data demonstrating the effect of T-2 on cellular and humoral responses in gut-associated lymphoid tissue (GALT), this study set out to investigate the effects of chronic exposure to low doses of the T-2 toxin (200 μg T-2 toxin kg⁻¹ feed) on percentages of CD4⁺ and CD8⁺ T lymphocytes, CD4⁺/CD8⁺ double-positive T lymphocytes, CD21⁺ B cells, and IL-2, IFN-γ, IL-4 and IL-10 mRNA expression levels in porcine ileal Peyer’s patches. The investigated material comprised ileum sections sampled from piglets (aged 8-10 weeks, body weight of 15-18 kg) on days 14, 28 and 42 of the experiment. After 42 days of exposure to T-2, a significant drop in the quantity of the IL-10 product was observed (R=0.94; S.E. 0.49-0.79; p<0.001). A gradual decrease in the amount of IL-4 and IFN-γ cytokine transcripts was found throughout the experiment, but the reported trend was not significant. On experimental days 14 and 42, a significant increase in the percentage of CD8⁺ T lymphocytes was observed in comparison with the control (p=0.04 and p=0.05, respectively), whereas on day 28, a significant decrease in the percentage of the above subpopulation was noted (p=0.00). The percentage of CD21⁺ B cells in the experimental group decreased steadily in comparison with the control, and the observed drop was significant on days 28 and 42 (p=0.06 and p=0.00, respectively). On days 14 and 28, the percentages of CD4⁺ and CD8⁺ T lymphocytes were lower in the experimental animals than in the control group, and the drop reported on day 28 was statistically significant (p=0.03).
Źródło:: Polish Journal of Veterinary Sciences; 2013, 16, 2
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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