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Tytuł:
The effects of experimental administration of low doses of zearalenone on the histology of ovaries in pre-pubertal bitches
Autorzy:
Gajęcka, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087998.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The experiment involved 30 clinically healthy Beagle bitches aged approximately 70 days with an initial body weight of approximately 8 kg. The animals were randomly divided into two experimental groups (EI and EII) and a control group of 10 animals each. Group EI was administered 50 μg of body weight zearalenone/kg per os for 42 days, group EII received 75 μg of body weight zearalenone/kg per os for 42 days, and the control group was administered placebo per os for 42 days. The bitches were ovariectomized at the end of the treatment period for anatomopathological examination. At the same time, peripheral blood samples were collected for endocrinological analyses (17β-estradiol and progesterone). Administartion of zearalenone particularly higher doses, resulted in the hyperestrogenism degeneration and atrophy of ovarian cells and tissues with accompanying edema and blood extravasation, leading to increased 17β-estradiol concentrations and an insignificant decrease in progesterone levels.
Źródło:
Polish Journal of Veterinary Sciences; 2013, 16, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of experimental low zearalenone intoxication on ovarian follicles in pre-pubertal bitches
Autorzy:
Gajecka, M.
Powiązania:
https://bibliotekanauki.pl/articles/32335.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Companion animals, including bitches, may be exposed to zearalenone (ZEN) toxins that are often present in feed, and ZEN intoxication may lead to ovarian dysfunction. This study involved evaluation of the degree of ZEN-induced hypo stimulation of ovary by determination of proliferative and apoptotic indices and description of the ultra-structural organization of ovarian follicles in pre-pubertal bitches subjected to experimental, long-term exposure to low-dose ZEN mycotoxicosis. The experiment involved 30 clinically healthy, immature Beagle bitches aged approximately 70 days with initial average body weight of 8 kg, randomly divided into three groups of 10 animals each: two experimental groups (EI and EII) and a control group (C). Over a period of 42 days, ZEN was administered per os to EI animals at a dose of 50 μg/kg BW, and to EII bitches at a dose of 75 μg/kg BW. Control group animals were fed placebo containing no ZEN for 42 days. Analytical samples of the mycotoxin were administered daily in gelatin capsules before morning feeding. All the bitches were subjected to ovario-hysterectomy at the end of the experiment. Proliferation index (PCNA method) and apoptotic index (TUNEL test) values were determined by immune-histological analyses. The median for apoptotic index was determined at 13.45 for group EI, 17.84 for group EII, and 8.59 for group C. The median for proliferation index was determined at 35.25 for group EII, 42.44 for group EI, and 70.60 for group C. The results of ultra-structural examinations of the ovaries revealed that experimental, ZEN-induced hyperestrogenism enhanced apoptosis and lowered the proliferative ability of follicular cells what contributed to organelle destruction in pre-pubertal bitches. The changes observed were particularly advanced in EII animals, which were administered a higher dose of ZEN.
Źródło:
Polish Journal of Veterinary Sciences; 2013, 16, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of low-dose experimental zearalenone intoxication on the immunoexpression of estrogen receptors in the ovaries of pre-pubertal bitches
Autorzy:
Gajecka, M.
Powiązania:
https://bibliotekanauki.pl/articles/30584.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Zearalenone is an estrogenic mycotoxin that often contaminates plant material used in the production of feeds for companion animals. Small daily doses of ingested zearalenone - a competitive substrate modulating the activity of enzymes participating in estrogen biosynthesis at the pre-receptor level - can induce subclinical symptoms of hyperestrogenism in bitches. The objective of this study was to determine the effects of low zearalenone doses on the presence of estrogen receptors in the ovaries of pre-pubertal Beagle bitches. The bitches were divided into three groups of 10 animals each: experimental group I - 50 μg zearalenone/kg body weight administered once daily per os; experimental group II - 75 μg zearalenone/kg body weight administered once daily per os; control group - placebo containing no ZEN administered per os. The animals were ovariorectomized at the end of the experiment, at 112 days of age. Estrogen receptors were detected in ovarian specimens by immunohistochemical methods. The results revealed an absence of estrogen receptors alpha in all groups. In both experimental groups a decrease in the positive response of estrogen receptors beta in specified structures of ovaries was observed. Very low α-zearalenol levels probably attested to the slowing down (hypostimulation) of the biotransformation process. Overall, zearalenone intoxication led to hyperestrogenism during a specific developmental stage of pre-pubertal bitches. As regards hormesis, the threshold dose of zearalenone (adaptive capability) was exceeded in the ovaries of experimental group II animals. The results obtained in both experimental groups suggest that long-term exposure to low-dose zearalenone intoxication decreased the degree of estrogen receptors beta staining in particular structures of ovaries in the experimental bitches, which initiated epigenetic modification mechanisms that inhibited ovarian development.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Czy mikotoksyny mogą być substancjami hamującymi w mleku?
Is mycotoxins can be used as inhibitors in milk?
Autorzy:
Gajecka, M.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/117.pdf
Data publikacji:
2014
Wydawca:
Instytut Innowacji Przemysłu Mleczarskiego
Tematy:
mleko krowie
krowy mleczne
zywienie zwierzat
lancuch paszowy
zanieczyszczenia pasz
zanieczyszczenia mikrobiologiczne
mikotoksyny
fumonizyny
zdrowotnosc zwierzat
Opis:
Zwierzęta mogą być narażone na działanie mikotoksyn w łańcuchu paszowym. Miko-toksyny występują głównie, jako zanieczyszczenia w paszy i mogą być wydalane w płynach biologicznych, takich jak mocz lub w mleku zwierząt lub ludzi, jako substancja macierzysta lub jako metabolit. Wiele prób dotyczących obecności mikotoksyn zostało przeprowadzonych na całym świecie i z badań tych wynika, że ma miejsce współwy-stępowanie mikotoksyn w materiałach paszowych i żywności. W rzeczywistości, wyni-ki sugerują, że w pewnych sytuacjach nawet 50% produktów mleczarskich może być zanieczyszczone przez mikotoksyny. Jednak opierając się na danych analitycznych w celu określenia stopnia ekspozycji mikotoksynami zwierząt i ludzi wyniki są słabo obiecujące ze względu na niejednorodny rozkład mikotoksyn w materiałach paszo-wych i produktach spożywczych, odstępu czasu pomiędzy pobraniem mikotoksyn, rozwojem choroby przewlekłej i niedokładności dietetycznych podczas określania danych w paszy i żywności. Jednak w porównaniu do innych płynów ustrojowych, takich jak krew, osocze czy mocz, to poziom wielu mikotoksyn w mleku zwierząt i ludzi jest raczej mały. Mleko matki jest istotnym źródłem mikotoksyn dla noworod-ków zwierząt i ludzi, ponieważ ich obecność została udokumentowana w próbkach pobranych w kilku krajach europejskich. Dlatego obecność mikotoksyny w mleku krów może być ważnym i poważnym problemem.
Animals can be exposed to mycotoxins through the feed chain. Mycotoxins are mainly found as contaminants in feed and could be subsequently excreted via biological fluids such as urine or animal breast milk in native or metabolized form. Many attempts to study the occurrence of mycotoxins have been carried out around the world and these surveys have commonly demonstrated the co-occurrence of mycotoxins in feed mate-rials and food. In fact, results suggest that in certain situations as much as 50% of the dairy products may be contaminated by mycotoxins. However, relying on analytical data for determining mycotoxin exposure of animal and human populations is difficult due to the heterogeneous distribution of mycotoxins in feed materials and food com-modities, the time lag between toxin intake and the development of chronic disease and the inaccuracies of dietary for determining feed and food intake data. Yet, in com-parison to other biological fluids such as blood, plasma and urine, the database on multi-mycotoxin levels in animal and human milk is rather small. Breast milk is a re-levant source of mycotoxins for animal and human neonates since their presence in samples collected in several European countries has been documented. Therefore, the presence of mycotoxins in cow's milk could be a important and serious problem.
Źródło:
Innowacyjne Mleczarstwo; 2014, 02, 1
2353-1282
Pojawia się w:
Innowacyjne Mleczarstwo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The low doses effect of experimental zearalenone (ZEN) intoxication on the presence of Ca2+ in selected ovarian cells from pre-pubertal bitches
Autorzy:
Gajecka, M.
Przybylska-Gornowicz, B.
Powiązania:
https://bibliotekanauki.pl/articles/31848.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The objective of this study was to determine the effect of 42-day ZEN intoxication on the presence of Ca2+ in selected ovarian cells from beagle bitches, using the potassium pyroantimonate (PPA) method. Samples were collected from 30 clinically healthy, pre-pubertal, genetically homogeneous animals. The bitches were divided into three groups of 10 animals each: experimental group I - 50 μg ZEN/kg BW (100% NOAEL) administered once daily per os; experimental group II - 75 μg ZEN/kg BW (150% NOAEL) administered once daily per os; control group - placebo containing no ZEN administered per os. An electron microscopic analysis revealed that cells died due to apoptosis, depending on the ZEN dose and the type of cells exposed to intoxication. Lower ZEN doses led to apoptosis-like changes in the cells. Cell death was a consequence of excess Ca2+ accumulation in the mitochondria, followed by cell dysfunction and a decrease in or the absence of mitochondrial metabolic activity in oocytes, follicle cells and interstitial cells in experimental bitches.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of dietary deoxynivalenol (DON) on selected blood biochemical and hematological parameters in pre-pubertal gilts
Autorzy:
Zielonka, L.
Gajecka, M.
Tarasiuk, M.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087992.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The aim of this study was to determine whether exposure to low doses of DON leads to changes in serum hematological and biochemical profiles. In the experiment, pre-pubertal gilts (with body weight of up to 25 kg) were administered DON per os at a daily dose of 12 |ig/kg BW (group E, n=18) or a placebo (group C, n=21) over a period of 42 days. Blood for analysis was sampled seven times at weekly intervals. Minor, but statistically significant changes were observed in selected indicators, particularly in weeks 2 and 3 in values of biochemical parameters such AlAT, AspAT, Pin and Fe, and in values of hematological parameters such as RBC, MCV, MCHC, PLT, MPV, WBC, neutrophil, eosinophil, lymphocyte and monocyte counts. In group E, a decreasing trend of the values was observed in most cases, except for RBC, PLT, eosinophil, lymphocyte and monocyte counts. Similar results were obtained in the last two weeks of the experiment. Initially, exposure to DON has a stimulating effect, which is eliminated when adaptive mechanisms are triggered. The results of the study indicate that the intensity of biotransformation processes varies subjected to the body's energy resources.
Źródło:
Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of selected environmental Fusarium mycotoxins on the ovaries in the female wild boar (Sus scrofa)
Autorzy:
Zielonka, L.
Gajecka, M.
Zmudzki, J.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/31466.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The contamination of agricultural crops with Fusarium mycotoxins poses one of the greatest problems in food production. Wild boars live in specific habitats and are physiologically sensitive to Fusarium mycotoxins, therefore, they are an interesting model for studies investigating the effects of the discussed toxin, in particular under low-dose exposure. The objective of this study was to determine potential effects of Fusarium mycotoxins ingested with naturally contaminated food on reproductive function based on the proliferation and apoptotic indices of ovarian follicles in female wild boars. The experiment was conducted on 40 wild boars inhabiting north-eastern Poland. The effect of seasonal variations in the quantity and quality of ingested food on the concentrations of Fusarium mycotoxins and their metabolites in the blood of wild boars was analyzed. The observed differences in toxin levels were accompanied by changes in proliferation and apoptotic indices. Proliferation processes were most intense in autumn-winter and were least advanced in winter-spring. The intensity of apoptotic processes was inversely correlated with proliferation.
Źródło:
Polish Journal of Veterinary Sciences; 2015, 18, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of arylamine N-acetyltransferase [NAT1 and NAT2] genotypes with urinary bladder cancer risk
Autorzy:
Jaskula-Sztul, R
Sokolowski, W.
Gajecka, M.
Szyfter, K.
Powiązania:
https://bibliotekanauki.pl/articles/2041980.pdf
Data publikacji:
2001
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
tobacco smoking
human genetics
genotype
urinary bladder
polymerase chain reaction
cancer
acetylator genotype
arylamine N-acetyltransferase
Źródło:
Journal of Applied Genetics; 2001, 42, 2; 223-231
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multi-mycotoxicosis
Autorzy:
Gajęcki, M.
Zielonka, Ł.
Obremski, K.
Jakimiuk, E.
Gajęcka, M.
Powiązania:
https://bibliotekanauki.pl/articles/363270.pdf
Data publikacji:
2007
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:
antagonizm
pasza
mykotoksyna
synergizm
antagonism
feed materials
mycotoxicosis
synergism
Opis:
Contamination of food and feeds with mycotoxins is a major problem of human and animal's health concern, and it is also extremely detrimental to economy. Mycotoxin-producing moulds may produce the most known mycotoxins, such as aflatoxins, ochratoxin, trichothecenes, zearalenone and fumonisin. Although toxicological, environmental and epidemiological studies have addressed the problem of these toxins one by one, more than one mycotoxin is found usually in the same contaminated commodities. That raises the incommensurable problem of multi-mycotoxicosis in which the respective metabolites are also involved. These mycotoxins bear potential toxicity leading to acute and chronic effects in humans and animals, depending on species. The mechanisms that lead to toxic effects, such as immune toxicity and carcinogenicity, are complex. The risk assessment for humans potentially exposed to multi-mycotoxins suffers very much from the lack of adequate food consumption data. Furthermore, for a given mycotoxin additive, synergism and antagonism with other mycotoxins found in the same food commodities are usually not taken into account.
Źródło:
Environmental Biotechnology; 2007, 3, 1; 25-29
1734-4964
Pojawia się w:
Environmental Biotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical evaluation of apoptosis and proliferation in the mucous membrane of selected uterine regions in pre - pubertal bitches exposed to low doses of zearalenone
Autorzy:
Stopa, E.
Babinska, I.
Zielonka, L.
Gajecki, M.
Gajecka, M.
Powiązania:
https://bibliotekanauki.pl/articles/30158.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Mycotoxins are toxic secondary metabolites produced by fungi. Those biologically active compounds occur naturally and they include zearalenone (ZEN), a mycotoxin that contaminates plant material, including the ingredients used in the production of commercial dog food. The influence of monotonic, low-dose and long-term exposure to ZEN on pre-pubertal bitches has not been fully explored to date. This paper describes a 42-day experiment performed on clinically healthy female dogs aged approximately 70 days, with estimated body weight of 8 kg. The animals were randomly divided into two experimental groups (EI and EII) and a control group (C) of 10 animals each. Group EI received 50 μg ZEN/kg (of body weight) per os, group EII received 75 μg ZEN/kg BW per os, and the control group was administered placebo. The bitches were ovariohysterectomized at the end of the experiment (at around 112 days of age), and selected sections of the uterine wall were subjected to immunohistochemical analyses (TUNEL and PCNA). A shift towards higher apoptotic (AI) and proliferative index (PI) was observed, in particular in group EI. Higher AI and PI values were noted in the epithelium of all uterine regions analysed and in the uterine glands in the uterine horn proximal to the body of the uterus.
Źródło:
Polish Journal of Veterinary Sciences; 2016, 19, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of exogenous proteases on selected hematological and serum biochemical parameters in boars
Autorzy:
Zielonka, L
Przewoski, W.
Gajecka, M.
Jakimiuk, E.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/32369.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
boar
farm animal
pig
enzymatic complex
enzymatic growth promoter
hematological parameter
serum
biochemical parameter
proteolytic enzyme
physiological norm
nitrogen metabolism
Opis:
The increasing interest in enzymatic growth promoters prompted this investigation of the effect of an enzymatic stimulating complex on selected hematological and serum biochemical parameters in boars. The enzymatic complex [five proteases (proteinases-endopeptidases) and two peptidases (exopeptidases) obtained by fermentation from Streptomyces fradiae] was added to diets for three months, at initial doses of 90 (group El) and 120 (group E2) g/ton feed for the first seven days followed by 40 and 60 g/ton, respectively, in the subsequent weeks. The evaluation was based on selected hematological (RBC, WBC, HCT (Ht), HGB (Hb), MCV, MCH, and MCHC) and biochemical (AST, ALT, AP, Ca, Mg, urea, cholesterol, creatinine, inorganic phosphorus, and oxyglucose) parameters determined before and after the experimental period. The reported values were within physiological norms. Statistical differences were found between experimental groups with respect to WBC, HCT (Ht), MCV, MCH, AP, Ca, Mg, creatinine, and inorganic phosphorus. The study results indicate that the complex of proteolytic enzymes administered to boars caused no negative changes in their metabolic profiles. The statistically different hematological and serum biochemical parameters, while within normal limits, point to an early stage of microcytic anemia and heightened agitation that could be the result of intensified nitrogen metabolism.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 1; 151-156
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zearalenone and deoxynivalenol mycotoxicosis in dairy cattle herds
Autorzy:
Marczuk, J.
Obremski, K.
Lutnicki, K.
Gajecka, M.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/30407.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Mycotoxin contaminations pose a growing problem in animal production from the economic and toxicological point of view. Clinical symptoms of mycotoxicosis are relatively unspecific, making the disease difficult to diagnose. This study presents a clinical case of dairy cattle infected with natural mycotoxins produced by fungi of the genus Fusarium (zearalenone [ZEA] and deoxynivalenol [DON]) in eastern Poland. In dead and infected cows, the presence of ZEA and DON was determined in the blood serum, significant changes were observed in blood morphological and biochemical profiles, extravasations and bowel inflammations were also observed. The results reported testify to an acute autoimmune process in the intestines as well as immunosuppression.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of deoxynivalenol on the levels of toll-like receptors 2 and 9 and their mRNA expression in enterocytes in the porcine large intestine: a preliminary study
Autorzy:
Dabrowski, M.
Jakimiuk, E.
Gajecka, M.
Gajecki, M.T.
Zielonka, L.
Powiązania:
https://bibliotekanauki.pl/articles/32154.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Deoxynivalenol (DON), one of the most prevalent mycotoxins in the world, and is capable of inducing immune disorders in humans and animals. The aim of this study was to determine the effect of feed contaminated with DON on the number of TLR2- and TLR9-positive cells and their mRNA expression in the porcine large intestine. The experiment was conducted on two equal groups of pigs (n=4). The experimental group (E) was administered feed contaminated with DON (1008 μg/kg of feed) for 6 weeks, and the control group (C) was administered non-contaminated feed over the same period of time. A decrease in the expression of TLR2 mRNA was noted in the cecum. The percentage of TLR9-positive enterocytes increased in the ascending colon and decreased in the cecum. The results of this study indicate that DON can modify the local immune response by changing the expression of TLRs.
Źródło:
Polish Journal of Veterinary Sciences; 2017, 20, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cecal enzyme activity in gilts following experimentally induced Fusarium mycotoxicosis
Autorzy:
Slizewska, K.
Nowak, A.
Piotrowska, M.
Zakowska, Z.
Gajecka, M.
Zielonka, L.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087975.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The objective of the presented study was to examine the influence of Fusarium mycotoxins (zearalenone - ZEN and deoxynivalenol - DON), administered separately and in combination, on the activity of cecal enzymes (ß-glucosidase and ß-glucuronidase) in gilts which were fed fodder contaminated with these mycotoxins. The activity of ß-glucosidase and ß-glucuronidase varied in the range of 0.170-1.236 μmol • h-1 • mg-1 and 8.701-96.704 μmol • h-1 • mg-1, respectively. In the first two weeks, the toxins had no significant effect on the activity of ß-glucosidase and ß-glucuronidase in the ascending and descending colon. After week 3 and later on, ZEN and DON administered as a mixture led to the highest increase in the activity of both enzymes. Administered separately, DON affected the activity of enzymes more than ZEN. From the third week of the experiment, an increase in the activity of CW ß-glucosidase and ß-glucuronidase was observed.
Źródło:
Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of selected serum biochemical and haematological parameters in gilts exposed per os to 100 ppb of zearalenone
Autorzy:
Jakimiuk, E.
Radwinska, J.
Pomianowski, A.
Wozny, M.
Obremski, K.
Gajecka, M.
Brzuzan, P.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/30098.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Zearalenone (ZEN) widely contaminates animal feed of plant origin. The recommended safe concentrations of ZEN in feeds for various animal species are set mainly based on the mycotoxin’s hormonal properties (NOEL). Our growing knowledge about biologically active concentrations of ZEN, molecular mechanisms and cells/tissues targeted by ZEN indicates that the harmful effects exerted by this mycotoxin on animals may be far greater than previously believed. This experiment was performed on pre-pubertal gilts divided into a control group (n=9) and an experimental group (ZEN, n=9). The control group received placebo, whereas the experimental group was administered ZEN at a dose of 0.1 mg/kg feed (equivalent to 5 μg/kg BW/day) for 42 days. On days 14, 28 and 42 blood samples were collected from the animals to determine the concentrations of selected zearalenols, serum biochemical and haematological parameters. Conjugated ZEN was found in the blood serum of the experimental gilts. Changes in the analysed biochemical parameters included a transient increase in albumin and cholesterol levels. A statistically significant increase in the concentrations of neutrophilic and acidophilic granulocytes was observed in the white blood cell system. The results indicate that long-term per os exposure of pre-pubertal gilts to low doses of ZEN (below NOEL) has a modulatory effect on liver function and white blood cells.
Źródło:
Polish Journal of Veterinary Sciences; 2015, 18, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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