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Wyświetlanie 1-12 z 12
Tytuł:
Accelerating PageRank computations
Autorzy:
Wierzchoń, S. T.
Kłopotek, M. A.
Ciesielski, K.
Czerski, D.
Dramiński, M.
Powiązania:
https://bibliotekanauki.pl/articles/206365.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
Page rank
power method
Jacobi iterations
Monte Carlo
Opis:
Different methods for computing PageRank vectors are analysed. Particularly, we note the opposite behavior of the power method and the Monte Carlo method. Further, a method of reducing the number of iterations of the power method is suggested.
Źródło:
Control and Cybernetics; 2011, 40, 2; 259-274
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of chromosome aberrations, sister chromatid exchanges [SCE] and cell division kinetics in human lymphocytes exposed in vitro to new monophosphates of pyrimidine acyclonucleosides
Autorzy:
Ferenc, T
Rutkowski, M.
Bratkowska, W.
Hubner, H.
Draminski, M.
Powiązania:
https://bibliotekanauki.pl/articles/2044452.pdf
Data publikacji:
1998
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
statistical analysis
chromatid gap
chromosome number
enzyme activity
chromosome aberration
in vitro
chromosome gap
pyrimidine
phosphorylase
acyclonucleoside monophosphate
human lymphocyte
sister chromatid exchange
cell division
Opis:
Five newly synthesised monophosphates of two pyrimidine acyclonucleoside series, namely 1-N-[(2’-hydroxy)ethoxymethyl] and l-N-[(l’,3’-dihydroxy)- 2’-propoxymethyl] derivatives of 5- and 5,6-alkylated uracils were tested in vitro for chromosome aberrations and sister chromatid exchanges (SCE). Metaphase plates were obtained via microculture of human lymphocytes from heparinized peripheral blood. The compounds were tested in doses: 10, 20, 40, 80 and 150 µg per mL of culture. The tested compounds induced mainly chromatid gaps, less frequently chromosome gaps. A low number of mitoses with chromatid and chromosome breaks, acentric fragments, dicentric chromosomes and exchange figures were also observed. The tested compounds in doses: 40, 80 and 150 µg per mL, doubled or tripled the percentage of cells with chromatid gaps and chromosome gaps as compared to the control. The percentage o cells with aberrations (excluding gaps) induced by the tested compounds in all doses did not exceed 2%. The tested compounds induced a higher number of SCE per cell but less than double frequency as compared to the control. SCE frequencies and replication index (RI) values varied depending on the examined compounds. For the highest dose of the tested compounds (150 µg per mL) a significant decrease in RI values was observed for l-N-[(2’-hydroxy)ethoxymethyl]-5,6-tetramethyleneuracil monophosphate and for l-N-[(2’-hydroxy)ethoxymethyl]-5,6-dimethyluracil monophosphate. So far, the results have indicated potential clastogenicity of all the tested compounds except acycloguanosine monophosphate.
Źródło:
Journal of Applied Genetics; 1998, 39, 1; 113-127
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enancjoselektywna enzymatyczna desymetryzacja katalizowana lipazami. Część 1, Związki prochiralne
Enantioselectve enzymatic desymmetrization catalyzed in the presence of lipase. Part 1, Prochiral compounds
Autorzy:
Kołodziejska, R.
Karczmarska-Wódzka, A.
Tafelska-Kaczmarek, A.
Studzińska, R.
Dramiński, M.
Powiązania:
https://bibliotekanauki.pl/articles/171684.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
związki prochiralne
desymetryzacja
transestryfikacja
hydroliza
lipazy
prochiral compounds
desymmetrization
transesterification
hydrolysis
lipase
Opis:
In the enzymatic asymmetric synthesis, the enzyme allows the desymmetrization of achiral compounds resulting in chiral compounds of high optical purity. Therefore, this type of biotransformation is known as enantioselective enzymatic desymmetrization (EED) [1–11]. This method is related to the generation of an asymmetry (loss of symmetry elements) in prochiral molecules (most often an sp3 or sp2 hybridized carbon atom), in meso synthones, and centrosymmetric compounds. An achiral center of the tetrahedral system is defined as a prochiral one if it becomes chiral as a result of one of the two substituents replacement which, when separated from the particles, are indistinguishable (Scheme 1, 2) [1–4, 9, 12]. Asymmetric synthesis is enantioselective when one of the enantiotopic groups or faces of an optically inactive compound is biotransformed faster than the other (Scheme 3–5) [1, 10, 11, 13–15]. Lipases are enzymes of highest importance in stereoselective organic synthesis, mainly due to their exceptionally broad substrate tolerance, stability, activity in unphysiological systems, and relatively low price [9, 14]. The mechanism of enzymatic hydrolysis catalysed by hydrolases is similar to that observed in the chemical hydrolysis with the use of base. The selectivity of enzymatic catalysis depends on the substrate orientation in the enzyme active site (Scheme 6, 7) [25–29]. Lipases were successfully used for the desymmetrization of different prochiral diesters, alcohols and amines. Most lipases preferentially convert the same prochiral groups in the above mentioned types of reaction. This allows the preparation of the both enantiomers of the product in high chemical and optical yield (Scheme 9–13) [9, 13, 32–56].
Źródło:
Wiadomości Chemiczne; 2013, 67, 7-8; 751-772
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enancjoselektywna enzymatyczna desymetryzacja katalizowana lipazami. Część II, Optymalizacja warunków reakcji. Związki mezo
Enantioselectve enzymatic desymmetrization catalyzed in the presence of lipase. Part II, Optymalization of reaction conditions. Meso compounds
Autorzy:
Karczmarska-Wódzka, A.
Kołodziejska, R.
Tafelska-Kaczmarek, A.
Przybyła, T.
Dramiński, M.
Powiązania:
https://bibliotekanauki.pl/articles/172192.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
związki mezo
desymetryzacja
transestryfikacja
hydroliza
lipaza
meso compounds
desymmetrization
transesterification
hydrolysis
lipase
Opis:
In the enzymatic asymmetric synthesis, the enzyme allows the desymmetrization of achiral compounds resulting in chiral compounds of high optical purity. Meso compounds (bearing a plane of symmetry) are very important group of compounds used in EEDs (Scheme 1) [1–4]. Similarly to prochiral compounds, selective acylation or hydrolysis of meso substrates leads to optically active products. Most lipases preferentially convert the same enantiomers in the above mentioned types of reaction. This allows the preparation of the both enantiomers of the product in high chemical and optical yield (Scheme 3–20) [35–58]. An effective enzymatic catalysis should be performed under conditions optimal for a biocatalyst performance. Hence, it is essential to select an appropriate reaction medium, the pH, and temperature [6–34]. Optimization of the reaction conditions in terms of an appropriate solvent selection is effective and most frequently the simplest way to modify the enzyme selectivity. One of the most important criteria for the solvent selection is its nature [25]. The enzyme selectivity is conditioned by its conformational rigidity, which increases in more hydrophobic medium (typical hydrophobic solvents, scCO2). A hydrophobic solvent decreases biocatalyst lability, which does not allow the connection between the structurally mismatched substrate and the active side of an enzyme [10, 26–31]. Ionic liquids are a separate group of solvents which, despite their high hydrophobicity (logP << 0) and polarity, can constitute an ideal medium for the biotransformation reactions [18–23].
Źródło:
Wiadomości Chemiczne; 2013, 67, 9-10; 819-841
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Map Quality Measurements for GNG and SOM based Document Collection Maps
Autorzy:
Kłopotek, M. A.
Wierzchoń, S. T.
Ciesielski, K.
Dramiński, M.
Czerski, D.
Kujawiak, M.
Powiązania:
https://bibliotekanauki.pl/articles/92814.pdf
Data publikacji:
2006
Wydawca:
Uniwersytet Przyrodniczo-Humanistyczny w Siedlcach
Tematy:
Search Engines
map of document collection
Opis:
The paper presents a proposal of a set of measures for comparison of maps of document collections as well as preliminary results concerning evaluation of their usefulness and expressive power.
Źródło:
Studia Informatica : systems and information technology; 2006, 1(7); 65-76
1731-2264
Pojawia się w:
Studia Informatica : systems and information technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prolina : pospolity aminokwas wyjątkowy katalizator. Część III, Reakcja Mannicha
Proline as a common amino acid and an exceptional catalyst. Part III, Mannich reaction
Autorzy:
Studzińska, R.
Karczmarska-Wódzka, A.
Wróblewski, M.
Kołodziejska, R.
Dramiński, M.
Powiązania:
https://bibliotekanauki.pl/articles/172649.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
prolina
reakcja Mannicha
synteza asymetryczna
proline
Mannich reaction
asymmetric synthesis
Opis:
Mannich reaction occuring among ketone, aldehyde, and amine is one of the ways of a synthesis of biologically active compounds. Reactions of this type were carried out in the presence of different catalysts [3–10], however in recent years a lot of attention has been paid to enantioselective Mannich reaction catalyzed with proline. Such reactions were carried out with the use of different compounds containing carbonyl group and the most frequently used amine was p-anisidine. The advantage of the use of p-anisidine is a possibility of conducting the direct Mannich reaction (Scheme 3). In this way β-amino ketones (Tab. 1, 2, 4) [15, 18–20, 23, 24], α-hydroxy-β-amino ketones (Tab. 3) [15, 22], and β-amino alcohols (Tab. 5, 6) [25, 26] were obtained. A possibility of syntheses of β-amino sugars and α-amino acids with their derivatives (Tab. 7) [28, 29] is worth noticing. In a great number of described reactions, the products were obtained with satisfactory yield and enantiomeric excess. Taking into consideration the difficulty of a removal of p-hydroxyphenyl group which protects amine group in the resulting products, the attempts of using different amine compounds in Mannich reactions catalyzed with proline were undertaken. The use of amines blocked by tert-butoxycarbonyl group (Boc) enabled to obtain the products with high yield and ee values (Tab. 12–15) [35–38]. However in the case of the use of Boc the reaction must be carried out in an indirect way (it is necessary to prepare imine blocked by Boc earlier).
Źródło:
Wiadomości Chemiczne; 2014, 68, 1-2; 21-48
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prolina : pospolity aminokwas wyjątkowy katalizator. Część IV, Reakcja Michaela
Proline as a common amino acid and an exceptional catalyst. Part IV, Michael reaction
Autorzy:
Karczmarska-Wódzka, A.
Studzińska, R.
Kołodziejska, R.
Wróblewski, M.
Dramiński, M.
Powiązania:
https://bibliotekanauki.pl/articles/171840.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
prolina
reakcja Michaela
synteza asymetryczna
proline
Michael reaction
asymmetric synthesis
Opis:
In recent years there has been a dynamic development of asymmetric synthesis. Groups of researchers, particularly the one led by Benjamin List and Carlos Barbas, carried out a number of reactions and showed the effectiveness of the use of small organic molecules such as proline as catalysts. Michael addition catalyzed with proline is a particularly interesting reaction because it can be carried out in two aminocatalytic pathways. The analysis of Michael reaction reveals potential for both forms of aminocatalysis: enamine and iminium catalysis (Scheme 1) [1–14]. Presumably Michael reaction proceeds mainly according to enamine mechanism. The use of proline in Michael reaction with imine activated acceptor is slightly effective. So far the researches have shown that the modification of proline molecule or addition of other catalyst is necessary for condensation to appear. Enamine catalysis concerns the activation of carbonyl compound in situ being a donor. There is no need for enolase anion to be created earlier [2, 15–17]. When, as a result of the reaction of a,b-unsaturated carbonyl compound with proline, Michael acceptor activation appears it means that it is enamine mechanism reaction (Scheme 1) [2, 24]. One of the first examples of direct Michael reaction proceeding through enamine transition state is the reaction of cyclopentanone with nitrostyrene (Scheme 6) [20–23]. Other examples of Michael addition of ketone with nitro olefin catalysed by proline are shown in table 2 and 3 [10, 23, 30]. Nitroketones obtained in that way are useful as precursors for different organic compounds [33], also pyrrolidines [34]. Pyrrolidines are pharmacologically active and they selectively block presynaptic dopamine receptors [34] (Scheme 7). Except for Michael intermolecular reaction, intramolecular condensation adducts were also obtained. Michael intramolecular proline-catalyzed condensation in which inactive ketones transform into α,β-unsaturated carbonyl compounds was described (Scheme 9) [35, 36]. These reactions require a stoichiometric amount of a catalyst and a long time of reaction and they give as a result a little enantiomeric excess [11, 24, 35]. In 1991, Yamaguchi and co-workers carried out malonates Michael addition to α, β-unsaturated aldehydes catalyzed by L-proline [24, 39]. The reaction proceeded according to enamine mechanism, for example dimethyl malonate was reacted with hex- 2-enal in the presence of proline to give Michael adduct in 44% yield. To improve the yield an attempt of a slight modification of a proline molecule was made transforming it into proper salt. Proline lithium salt enabled to obtain the condensation product in 93% yield (Tab. 4). Regardless of a used catalyst the products in the form of racemates were obtained. In order to improve enantioselective properties of a catalyst, Michael addition of diisopropyl malonate to cycloheptenone was carried out in chloroform in the presence of different proline salts. Optimal enantioselectivity and yield was obtained by using rubidium salt (Tab. 5–7) [40, 41]. Rubidium prolinate-catalyzed Michael additions are used in industry e.g. for enantioselective synthesis of the selective serotonine reuptake inhibitior (SSRI) (–)-paroxetine (antidepressant) (Scheme 12) [24].
Źródło:
Wiadomości Chemiczne; 2014, 68, 1-2; 49-65
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prolina – pospolity aminokwas wyjątkowy katalizator. Część I, Biosynteza proliny. Wewnątrzcząsteczkowa kondensacja aldolowa
Proline as a common amino acid and an exceptional catalyst. Part I, Proline biosynthesis. Intramolecular aldol reaction
Autorzy:
Wróblewski, M.
Kołodziejska, R.
Studzińska, R.
Karczmarska-Wódzka, A.
Dramiński, M.
Powiązania:
https://bibliotekanauki.pl/articles/172473.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
biosynteza proliny
mechanizm kondensacji aldolowej
wewnątrzcząsteczkowa reakcja aldolowa
proline biosynthesis
mechanism of aldol reaction
intramolecular aldol reaction
Opis:
In asymmetric synthesis of organic compounds more effective solutions are being looked for which will result in higher yield(s) of product(s) and their high enantioselectivity [1]. One of such solutions is an use of a multilevel and cheap catalyst. Proline used as a catalyst is a substance of natural origin which was synthetically obtained by Willstätter who was carrying out research on hygric acid (Scheme 1) [10]. The cells of many organisms have a suitable enzymatic system essential for proline biosynthesis [15]. So far, three proline biosynthesis pathways have been described: from glutamate (Scheme 3 and 4), ornithine (Scheme 5 and 6), and arginine (Scheme 7) [16–28]. Proline which is obtained as a result of biosynthesis or supplementation is a substrate for many proteins. Characteristic and significant content (about 23%) of this amino acid was observed in collage. In cells proline can play an important role of osmoregulator [31–35] – a protective substance regulating the activity of such enzymes as catalase and peroxidase [36]. Proline as a secondary amine shows exceptional nucleophilicity facilitating imine and enamine formation. Used as a catalyst in aldol reaction makes with substrates like imine or enamine transition state imitating the activity of naturally occurring enzymes for this type of reaction, that is aldolases. In their research Hajos and Parrish, and Eder, Sauer and Wiechert used proline in intramolecular aldol reaction obtaining proper enones (Scheme 9) [60–62]. The process of intramolecular aldol reaction was used for a separation of racemic mixture of diketones (Scheme 10) [63, 64], cyclization of ortho-substituted aromatic aldehydes and ketones (Scheme 11) [65], synthesis of cyclic diketones (Scheme 13) [68] and domino reaction to obtain substituted cyclohexanones from beta-diketones and unsaturated ketones (Scheme 14) [69].
Źródło:
Wiadomości Chemiczne; 2013, 67, 9-10; 801-818
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prolina – pospolity aminokwas wyjątkowy katalizator. Część II, Międzycząsteczkowa kondensacja aldolowa
Proline as a common amino acid and an exceptional catalyst. Part II, Intermolecular aldol reaction
Autorzy:
Kołodziejska, R.
Wróblewski, M.
Karczmarska-Wódzka, A.
Studzińska, R.
Dramiński, M.
Powiązania:
https://bibliotekanauki.pl/articles/171560.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
międzycząsteczkowa reakcja aldolowa donor
akceptor
prolina
anti-aldole
intermolecular aldol reaction
donor
acceptor
proline
anti-aldol
Opis:
Proline in organic synthesis is used as a small molecular organocatalyst. In a catalytic act proline, similarly to an enzyme, activates reagents, stabilizes transition state and influences an orientation of substrates [1–12]. Proline works as aldolase I (so called microaldolase I). In comparison with other amino acids it shows exceptional nucleophilicity which makes imines and enamines formation easier. In the intermolecular aldol reaction proline was used for the first time by List and co-workers (Scheme 1) [3, 9, 20]. Since then an immense progress has been observed in this field. Several aldolization reactions were performed in the presence of proline. Reactions of this type proceed between the donor (nucleophile) and the acceptor (electrophile). In aldol reaction the donors can be both ketones and aldehydes which next are condensed with ketones and aldehydes acting as electrophiles (Scheme 2–18; Tab. 1–7) [21–72]. The presence of proline ensures not only high yield of homo- and heteroaldolization but mainly enables conducting enantio- and diastereoselective synthesis. Intermolecular proline-catalyzed aldol condensation proceeds according to enamine mechanism. Anti-aldols, which make a valuable source of intermediates in the synthesis of important biologically active compounds, are mainly obtained in this reaction [35–44, 54, 58, 62, 63, 68, 69, 71].
Źródło:
Wiadomości Chemiczne; 2013, 67, 11-12; 1027-1050
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reakcja Mitsunobu : mechanizm i zastosowanie
Mitsunobu reaction : mechanism and application
Autorzy:
Kitkowska, J. D.
Tabaczyńska, Ż. A.
Dramiński, M.
Powiązania:
https://bibliotekanauki.pl/articles/171670.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
reakcja Mitsunobu
kondensacja
inwersja konfiguracji
stereoselektywność
Mitsunobu reaction
condensation
configuration inversion
stereoselectivity
Opis:
The Mitsunobu reaction has been known since 1967, but the research on its modifications as well as on the introduction of new reagents, productivity, improvement and methods of post-reaction mixture separation is still being conducted. The original reaction was used to obtain esters by condensation of carboxylic acids and alcohols using triphenylphosphine and DEAD mixture. This reaction allows formation of s not only carbon-oxygen bond, but also carbon-carbon, carbon-nitrogen, and carbon-sulphur to be synthesized. The Mitsunobu reaction is widely applied in organic synthesis as a way of inversion of configuration of secondary alcohols or of aryl ethers synthesis. Numerous studies bring the accounts of using this reaction for the synthesis of steroids, carbohydrates, nucleosides, as well as alkaloids and other heterocyclic compounds containing nitrogen. The popularity of this reaction lies in its stereoselectivity and compatibility with a wide range of functional groups as well as in its moderate requirements considering reaction conditions. However, an isolation of a desirable product from the used up or surplus reagents still causes a lot of difficulties.
Źródło:
Wiadomości Chemiczne; 2013, 67, 9-10; 843-876
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Semantic information within the BEATCA framework
Autorzy:
Ciesielski, K.
Czerski, D.
Dramiński, M.
Kłopotek, M. A.
Wierzchoń, B.
Powiązania:
https://bibliotekanauki.pl/articles/969819.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
semantic information
clustering with partial multilabel supervision
Opis:
In this paper we investigate the impact of semantic information on the quality of hierarchical, fuzzy-based clustering of a collection of textual documents. We show that via a relevant tagging of a part of the documents one can improve the quality of overall clustering, both of tagged and un-tagged documents.
Źródło:
Control and Cybernetics; 2010, 39, 2; 377-399
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Monte Carlo feature selection and interdependency discovery is unbiased
Autorzy:
Dramiński, M.
Kierczak, M.
Nowak-Brzezińska, A.
Koronecki, J.
Komorowski, J.
Powiązania:
https://bibliotekanauki.pl/articles/205575.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
supervised classification
feature selection
feature interactions
high-dimensional problems
applications to genomic and proteomic data
Opis:
We show that the Monte Carlo feature selection algorithm for supervised classification proposed, by Dramiński et al. (2008), is not biased towards features with many categories (levels or values). While the algorithm, later extended to include the functionality of discovering interdependencies between features, is surprisingly simple and has been successfully used on many biological data and transactional data of commercial origin, and it has never revealed any bias of the type mentioned, the alleged property of its unbiasedness required a closer scrutiny which is thus provided here. Admittedly, the algorithm does reveal some bias coming from another source, but it is negligible. Hence our final claim is that the algorithm is practically unbiased and the results it provides can be considered fully reliable.
Źródło:
Control and Cybernetics; 2011, 40, 2; 199-211
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-12 z 12

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