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    Wyświetlanie 1-15 z 15
    Tytuł:
    Study on condition prediction and influencing factors of manganese carbonate recovery by high gradient pulse magnetic separation
    Autorzy:
    Wang, Zhenggang
    Nie, Guanghua
    Tang, Yun
    Piao, Haishan
    Chen, Jian
    Powiązania:
    https://bibliotekanauki.pl/articles/24085829.pdf
    Data publikacji:
    2023
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    mineral particles
    impulse
    volume susceptibility
    magnetic field strength
    DLVO theory
    Opis:
    Manganese carbonate ore belongs to weakly magnetic minerals, and its co-associated minerals are mainly non-magnetic minerals, which can be separated from gangue minerals at high magnetic field intensity. However, manganese grade and recovery of magnetic separation concentrate of manganese carbonate ore are low in actual production. Therefore, the influences of manganese carbonate particle size, magnetic field intensity, volume susceptibility, pulse stroke, pH, and other factors were studied. The optimal test conditions for manganese carbonate ore recovery by high-gradient magnetic separation were predicted through the calculation results. The results show that the particle radius of manganese carbonate is 0.020 mm, the pulse impulse time is 200 r/min, and the magnetic field intensity is 0.9 T. The optimum condition test was carried out with Qianbei manganese carbonate ore as the material. The test results show that the optimum conditions are the particle radius of 0.074-0.019 mm, pulse impulse time of 200 r/min, and magnetic field intensity of 1.2 T. The reason for the deviation is that the actual ore has a fine distribution particle size, many associative bodies, complex composition, and serious agglomeration, resulting in variable particle volume susceptibility. The capture yield increases with the increase of magnetic field intensity and volume susceptibility but decreases with the increase of pulse. The lower the surface potential of manganese carbonate, the higher the recovery of manganese carbonate. The grade of manganese concentrate was 19.06% and the recovery was 76.85%. Mixed manganese concentrate with a grade of 18.04% and recovery of 87.14% was obtained by adding drugs and changing the grinding method.
    Źródło:
    Physicochemical Problems of Mineral Processing; 2023, 59, 3; art. no. 168668
    1643-1049
    2084-4735
    Pojawia się w:
    Physicochemical Problems of Mineral Processing
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Factors influencing the mental health status of support nurses and their workload during the COVID-19 epidemic
    Autorzy:
    Dai, Zhen-Juan
    Xu, Shen-Ting
    Xue, Fang-Ying
    Zhou, Jian-Ying
    Chen, Jian-Qin
    Wang, Xue-Min
    Powiązania:
    https://bibliotekanauki.pl/articles/23369109.pdf
    Data publikacji:
    2023-12-15
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    COVID-19
    mental health
    epidemic prevention and control
    general mental health questionnaire
    NASA-TLX
    support nurse
    Opis:
    Objectives The authors used the National Aeronautics and Space Administration Task Load Index (NASA-TLX) and general health questionnaire to analyze the factors influencing the mental health status and the workload of support nurses during the COVID-19 epidemic. Material and Methods The authors conducted a cross-sectional survey of 349 support nurses in April–October 2022. Using QuestionStar, a powerful online survey tool, the authors administered surveys to the participants, collected data on the mental health status and workload of support nurses, and analyzed the influencing factors based on the collected data. Results A total of 316 questionnaires were successfully collected, with an effective rate of 98.75%. The proportion of support nurses with mental health problems was 25% and the value of the NASA-TLX questionnaire was: M±SD 68.91±7.28 pts. Multi-factor analysis revealed that the number of children, family support, and nursing support location were the influencing factors of mental health status, while the multivariate analysis revealed that the presence of symptoms, nursing support location, support work type, and total 12-item General Health Questionnaire (GHQ-12) score were the influencing factors of the workload of support nurses. Conclusions Compared to their counterparts in the plains, nurses working in isolated plateau regions who were caring for children and lacked family support, were more likely to have mental health issues. There was a positive correlation between the changes in GHQ-12 and NASA-TLX scores of the study participants. Compared to their counterparts in the plains and the tropical regions, nurses working in plateau regions had a heavier workload. As part of the follow-up measures to prevent and treat patients impacted by the COVID-19 epidemic, it is important to improve the mental health evaluation, consultation, and treatment of the support nurses to guarantee the high quality of the first-line support work.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2023, 36, 6; 761-772
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Crystal Structure and Thermal Behaviour of Imidazolium 2,4,5-Trinitroimidazolate
    Autorzy:
    Jian, Chen
    Pengbao, Lian
    Lizhen, Chen
    Jianlong, Wang
    Jun, Chen
    Powiązania:
    https://bibliotekanauki.pl/articles/357998.pdf
    Data publikacji:
    2019
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    imidazolium 2,4,5-trinitroimidazolate
    crystal structure
    thermal decomposition
    TG-DSC
    model-free methods
    Opis:
    In this work, imidazolium 2,4,5-trinitroimidazolate was obtained from 2,4,5-tri-iodoimidazole in a yield of 48%. Single-crystal X-ray diffraction analysis showed that this compound belongs to the triclinic crystal system with space group P-1. Thermogravimetric-differential scanning calorimetry (TG-DSC) was performed under a nitrogen atmosphere at heating rates of 5, 10, 15 and 20 °C·min−1. Compound 3 clearly exhibits an exothermic decomposition. The activation energy (E) and pre-exponential factor (lnA) calculated by the Kissinger method were 113.67 kJ·mol−1 and 25.30 s−1, respectively. The E values obtained by the FWO and KAS methods changed slightly from 103.33 to 113.69 kJ·mol−1 and from 101.52 to 111.97 kJ·mol−1, respectively, which makes us believe that its thermal decomposition can be described using only one reaction model. The Šatava-Šesták method and the compensation effect were used to study the thermal decomposition mechanism of imidazolium 2,4,5-trinitroimidazolate. [Formula] is regarded as the most appropriate thermal decomposition kinetic equation. The impact sensitivity, friction sensitivity, detonation velocity and explosion pressure of imidazolium 2,4,5-trinitroimidazolate were 43 cm, 46%, 7056.9 m·s−1 and 1.9703 · 1010 Pa (ρ = 1.538 g·cm−3), respectively. Imidazolium 2,4,5-trinitroimidazolate is incompatible with RDX, HMX, TKX-50 and CL-20.
    Źródło:
    Central European Journal of Energetic Materials; 2019, 16, 4; 547-563
    1733-7178
    Pojawia się w:
    Central European Journal of Energetic Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pollution, Happiness and Willingness to Pay Taxes:The Value Effect of Public Environmental Policies
    Zanieczyszczenie, szczęście i chęć płacenia podatków: efekt wartości w ramach publicznych polityk ekologicznych
    Autorzy:
    Liu, Nannan
    Liu, Rong
    Huang, Jian
    Chen, Lingshuang
    Powiązania:
    https://bibliotekanauki.pl/articles/371270.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Komitet Człowiek i Środowisko PAN
    Tematy:
    environmental pollution
    sense of happiness
    willingness to pay taxes
    public policy
    zanieczyszczenia środowiska
    poczucie szczęścia
    podatki oparte na gotowości do zapłaty
    polityka publiczna
    Opis:
    As China’s economic development pattern is marked by an excessive consumption of fossil fuels, environmental pollution problems in China are getting increasingly serious and threatening residents’ fundamental demands for a high quality of life. It has become a handicap to sustainable economic development and social well-being. In this paper, the happiness index method were used, and models depicting the relationship between residents’ sense of happiness and environmental pollution factors and between the willingness to pay taxes and environmental pollution factors have been established. The results show that environmental pollution, especially air pollution, significantly affects the residents’ sense of happiness. To improve residential environment quality and reduce pollution, residents are willing to pay the relevant taxes. If pollution control is considered a public policy, there exists a substantive weight of government between residents’ income and environmental quality. This will influence the choice of environmental public policy.
    Rozwój ekonomiczny Chin powiązany jest z nadmiernym zużywaniem paliw kopalnych, a zanieczyszczenia środowiska osiągają poziom, który stanowi zagrożenie dla oczekiwanego przez obywateli wysokiego poziomu życia. Stało się to przeszkodą dla zrównoważonego rozwoju gospodarczego i dobrobytu społecznego. W niniejszym opracowaniu wykorzystano metodę wskaźnika szczęścia. Opracowano modele obrazujące związek między poczuciem szczęścia mieszkańców a zanieczyszczeniami środowiska oraz między chęcią płacenia podatków a czynnikami zanieczyszczenia środowiska. Wyniki pokazują, że zanieczyszczenie środowiska, w szczególności zanieczyszczenie powietrza, znacząco wpływa na poczucie szczęścia mieszkańców. Aby poprawić jakość środowiska mieszkańców i zmniejszyć zanieczyszczenie, obywatele są skłonni zapłacić odpowiednie podatki. Jeżeli kontrola zanieczyszczeń jest uważana za politykę publiczną, rząd odgrywa istotną rolę w kształtowaniu relacji między dochodami mieszkańców a jakością środowiska. Wpłynie to bowiem na wybór polityki publicznej dotyczącej środowiska.
    Źródło:
    Problemy Ekorozwoju; 2018, 13, 1; 75-86
    1895-6912
    Pojawia się w:
    Problemy Ekorozwoju
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A modified Fourier-Ritz method for free vibration of rectangular plates with elastic constrains
    Autorzy:
    Wu, Tao
    Chen, Zhao Bo
    Qu, Jian Jun
    Powiązania:
    https://bibliotekanauki.pl/articles/2086961.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
    Tematy:
    modified Fourier-Ritz method
    rectangular plate
    free vibration
    boundary conditions
    Opis:
    In this paper, a modified Fourier-Ritz method is used to study free vibration of a rectangular plate with a set of simply supported opposite sides and another set of arbitrary elastic constraints. The influence of different elastic constraint stiffness values on the modal response of the rectangular plate is also analyzed. In order to avoid that the displacement function of the rectangular plate calculated by the traditional method and its derivative may be discontinuous or non-derivable at the boundary, the displacement function is expressed in the form of the sum of standard cosine series and a periodic polynomial function. Compared with the sine series expansion, the convergence of the result is enhanced. Several sets of numerical examples with different boundary conditions are given in the article, the data shows that the results calculated by this method have good accuracy and fast convergence. In addition, this paper also analyzes the boundary conditions and discusses the influence of different spring stiffness values on the setting of boundary conditions. The results can be applied to the setting of general boundary conditions and the study of vibration control of rectangular plates.
    Źródło:
    Journal of Theoretical and Applied Mechanics; 2022, 60, 1; 77--89
    1429-2955
    Pojawia się w:
    Journal of Theoretical and Applied Mechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Urinary concentrations and determinants of pyrethroid metabolites in pregnant women from non-rural areas of Yunnan, China
    Autorzy:
    Xu, Q.
    Song, X.
    Li, Y.
    Jian, X.
    Chen, S.
    Chen, Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/28762713.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2021, 28, 4; 627-632
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research on low frequency ripple suppression technology of inverter based on model prediction
    Autorzy:
    Liu, Haiyang
    Chen, Yiwen
    Luo, Sixu
    Jiang, Jiahui
    Jian, Haojun
    Powiązania:
    https://bibliotekanauki.pl/articles/24202730.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    boost type
    low frequency ripple suppression
    model predictive control
    single stage inverter
    Opis:
    The low frequency ripple of the input side current of the single-phase inverter will reduce the efficiency of the power generation system and affect the overall performance of the system. Aiming at this problem, this paper proposes a two-modal modulation method and its MPC multi-loop composite control strategy on the circuit topology of a single-stage boost inverter with a buffer unit. The control strategy achieves the balance of active power on both sides of AC and DC by controlling the stable average value of the buffer capacitor voltage, and provides a current reference for inductance current of the DC input side. At the same time, the MPC controller uses the minimum inductor current error as the cost function to control inductor current to track its reference to achieve low frequency ripple suppression of the input current. In principle, it is expounded that the inverter using the proposed control strategy has better low frequency ripple suppression effect than the multi-loop PI control strategy, and the conclusion is proved by the simulation data. Finally, an experimental device of a single-stage boost inverter using MPC multi-loop composite control strategy is designed and fabricated, and the experimental results show that the proposed research scheme has good low frequency ripple suppression effect and strong adaptability to different types of loads.
    Źródło:
    Archives of Electrical Engineering; 2023, 72, 2; 443--460
    1427-4221
    2300-2506
    Pojawia się w:
    Archives of Electrical Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An early warning method for a slope based on the increment ratio of anchor cable internal force
    Autorzy:
    Feng, Jianhua
    Chen, Jiaxin
    Li, Jian
    Zhang, Yu
    Guo, Jianhua
    Qiu, Hongyong
    Powiązania:
    https://bibliotekanauki.pl/articles/2203436.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Prestressed anchor cables are active reinforcement to improve slope stability. However, the anchoring is not a permanent guarantee of stability, and the slope retains a potential risk of instability. From the perspective of the internal force of anchor cables, a new early warning method for the safety of the slope is provided, and a slope analysis model is established. With the increase in the strength reduction factor, the internal force increment curves of anchor cables under different prestresses are obtained. The point corresponding to strength reduction factors λ1 and λ2 represents a warning point. Key conclusions are drawn as follows: (1) The internal force of an anchor cable can be used to judge the stability of the slope strengthened by a prestressed anchor cable. (2) A warning index based on the internal force increment ratio of anchor cables is established. (3) The internal force increment ratio of anchor cables eliminates the influence of the initial prestress and is convenient for engineering applications.
    Źródło:
    Archives of Civil Engineering; 2023, 69, 1; 553--569
    1230-2945
    Pojawia się w:
    Archives of Civil Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of socio-economic spatial structure of urban agglomeration in China based on spatial gradient and clustering
    Autorzy:
    He, Li
    Tao, Jian’ge
    Meng, Ping
    Chen, Dan
    Yan, Meng
    Vasa, László
    Powiązania:
    https://bibliotekanauki.pl/articles/19233717.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Badań Gospodarczych
    Tematy:
    economic and social development
    urban agglomeration
    Central Plains Urban Agglomeration (CPUA)
    clustering
    spatial gradient
    Opis:
    Research background: Previous studies on the economic and social development of urban agglomerations mostly focus on a single primacy comparative analysis and efficiency evaluation. Spatial structure differentiation is an important feature of urban agglomeration. The lack of economic and social analysis on the spatial structure makes it impossible to determine the development positioning of each city in the urban agglomeration, which affects the sustainable economic development ability of these areas. Purpose of the article: The objective of the article is to analyze the spatial development law and experience of urban agglomeration, this study explores the practice of economic and population spatial structure of city areas in China. For this purpose, CPUA and its central city Zhengzhou was taken as an example, the spatial gradient structure of example was analyzed. Methods: Using economic and population data of 32 cities in this region, growth pole theory, and pole-axis theory, the economic and population spatial structure of urban agglomeration, the spatial gradient structure of central cities in urban agglomerations were analyzed with the method of cluster about radiation index. Findings & value added: (1) In the process of the formation of CPUA, the geo-graphical spatial pattern plays a decisive role in economic and social development. This is an experience from developing countries. (2) CPUA presents a gradient development pattern with Zhengzhou as the center, and economic and social development gradually radiates to the metropolitan area, the core development area, and the character development demonstration area. (3) The economic and social gradients of Zhengzhou, the central city, present the hierarchy rules and characteristics which are driven by the Beijing-Guangzhou-Railway axis and the Longhai-Railway axis. (4) The central city of Zhengzhou still presents insufficient primacy in regional development, which shows that Zhengzhou accounts for 6% of the population of the Central Plains Economic Zone and 14% of GDP, and insufficient agglomeration. Different countries at different stages of economic development have different urban agglomeration development models. The conclusions from China provide new decision-making ideas and methods for spatial structure research and development strategy analysis of urban agglomerations.
    Źródło:
    Oeconomia Copernicana; 2021, 12, 3; 789-819
    2083-1277
    Pojawia się w:
    Oeconomia Copernicana
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fatigue reliability analysis of the brake pads considering strength degradation
    Autorzy:
    Zhang, Nan
    Jiang, Guang-Jun
    Wu, Dong-Wei
    Chen, Hong-Xia
    Wu, Jian-Xin
    Powiązania:
    https://bibliotekanauki.pl/articles/1841941.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
    Tematy:
    stress-strength interference model
    dynamic reliability
    strength degradation
    impact load
    Opis:
    Reliability prediction of the brake pads is indispensable to guarantee their safety. In the paper, the fatigue reliability of brake pads is analyzed by dynamic stress-strength interference (SSI) model considering strength degradation. Firstly, reliability model of the brake pads was established based on stress-strength interference model considering the influence of impact load. Then reliability of the brake pads was predicted under different impact load frequency and initial strength. Finally, the influence of random degradation strength on reliability was studied by contrast. The analysis results show that random strength degradation, impact load and initial strength have great influence on reliability prediction for the brake pads. Therefore, the reliability prediction of the brake pads fatigue strength considering strength degradation is more in line with the actual situation and the calculation accuracy is higher.
    Źródło:
    Eksploatacja i Niezawodność; 2020, 22, 4; 620-626
    1507-2711
    Pojawia się w:
    Eksploatacja i Niezawodność
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Isolation and expression pattern of RGS21 gene, a novel RGS member
    Autorzy:
    Li, Xin
    Chen, Lei
    Ji, Chaoneng
    Liu, Bing
    Gu, Jiefeng
    Xu, Jian
    Zou, Xianqiong
    Gu, Shaohua
    Mao, Yumin
    Powiązania:
    https://bibliotekanauki.pl/articles/1041351.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    RGS21
    G-protein signaling pathway
    G-protein α subunit (Gα)
    Opis:
    Regulators of G-protein signaling (RGS) proteins are known for the RGS domain that is composed of a conserved stretch of 120 amino acids, which binds directly to activated G-protein α subunits and acts as a GTPase-activating protein (GAP), leading to their deactivation and termination of downstream signals. In this study, a novel human RGS cDNA (RGS21), 1795 bp long and encoding a 152-amino acid polypeptide, was isolated by large-scale sequencing analysis of a human fetal brain cDNA library. Unlike other RGS family members, RGS21 gene has no additional domain/motif and may represent the smallest known member of RGS family. It may belong to the B/R4 subfamily, which suggests that it may serve exclusively as a negative regulator of αi/o family members and/or αq/11. PCR analysis showed that RGS21 mRNA was expressed ubiquitously in the 16 tissues examined, implying general physiological roles.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 4; 943-946
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The relationship between manganism and the workplace environment in China
    Autorzy:
    Wang, Yongyi
    Xue, Jian
    Cheng, Shuqun
    Ding, Yubin
    He, Junlin
    Liu, Xueqing
    Chen, Xuemei
    Wang, Yingxiong
    Feng, Xiangyu
    Xia, Yinyin
    Powiązania:
    https://bibliotekanauki.pl/articles/2180079.pdf
    Data publikacji:
    2012-09-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    manganese
    occupational exposure
    welding
    mining
    occupational intoxication
    chronic manganism
    Opis:
    Manganese is a trace element and a cofactor of many enzymes, so it is essential for physiologic functioning, but it is also a neurotoxin at high doses. Manganism is most often caused by occupational exposure. It is manifested by a myriad of signs and symptoms ranging from the neurasthenia syndrome, such as headache and dizziness, to the Parkinson-like syndrome, depending on the blood manganese levels as well as the duration of exposure. We are reporting a case of manganism using both clinical and occupational hygiene investigation methods. The patient presented the neurasthenia syndrome accompanied by hypertonicity of arm muscles and was diagnosed to have mild chronic manganism. Finally, the patient was discharged from the hospital after the treatment had improved her condition. In China, there are many chronic manga nese cases, partly due to a rapid industrial development with great use of Mn and the low self-protection awareness among the workers and the factories management that cannot catch up with the speed of the economical development. Therefore, factories are responsible for improving the conditions at the workplace.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 501-505
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A novel tetrameric lectin from Lycoris aurea with four mannose binding sites per monomer
    Autorzy:
    Liu, Jiwei
    Xu, Xiaochao
    Liu, Jinzhi
    Balzarini, Jan
    Luo, Yongtin
    Kong, Yang
    Li, Jian
    Chen, Fang
    Van Damme, Els
    Bao, Jinku
    Powiązania:
    https://bibliotekanauki.pl/articles/1041131.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    sequence alignment
    mannose-binding lectin
    Lycoris aurea agglutinin
    molecular modeling and docking
    Opis:
    The mannose-binding agglutinin from bulbs of Lycoris aurea (LAA) agglutinates rabbit but not human erythrocytes. The molecular mass of the monomer in SDS/PAGE is 12 kDa while the apparent molecular mass in gel filtration is 48 kDa, indicating that LAA is a homotetramer. The full-length cDNA of LAA contains 683 bp with an open reading frame encoding a protomer of 162 amino-acid residues. Hydrophobic Cluster Analysis and molecular modeling of the 109-residue mature polypeptide suggested a similar secondary and tertiary structure to those of Narcissus pseudonarcissus agglutinin (NPA). Molecular docking revealed that, besides the three mannose-binding sites common among Amaryllidaceae lectins, LAA also contains a fourth unique mannose-binding site formed by a tryptophan cluster. The existence of four mannose-binding sites in each monomer of LAA is very unusual and has only been reported for NPA earlier.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 1; 159-166
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Curcumin Prevents Free Fatty Acid-Induced Lipid Accumulation via Targeting the miR-22-3p/CRLS1 Pathway in HepG2 Cells
    Autorzy:
    Mei, Yuanyuan
    Sun, Xiaoting
    Huang, Shi-Ying
    Wu, Xiaowen
    Ho, Kuo-Ting
    Lu, Liming
    Chen, Chaoxiang
    Li, Jian
    Liu, Jingwen
    Li, Guiling
    Powiązania:
    https://bibliotekanauki.pl/articles/28408450.pdf
    Data publikacji:
    2024-02-13
    Wydawca:
    Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
    Tematy:
    polyphenol
    epigenetics
    liver
    steatosis
    mitochondria
    Opis:
    Dysregulated lipid metabolism in liver is an important hallmark of non-alcoholic fatty liver disease (NAFLD), which may be modulated by dietary polyphenols or microRNAs (miRNAs). However, the underlying epigenetic regulatory mechanism of polyphenols remain unclear. The current study aimed to address how miRNA mediates hepatic lipid metabolic control of curcumin, a polyphenolic food supplement. The results showed that 24 h treatment with 5 - 20 μM curcumin prevented free fatty acid-induced lipid accumulation by around 10 ~ 50% in HepG2 cells, which was attenuated by pre-transfection with 40 nM miR-22-3p mimic for 48 h. In consequence, transfection with 40 nM miR-22-3p inhibitor for 48 h significantly reduced lipid accumulation by around 10%. And 48 h overexpression of miR-22-3p targeting cardiolipin synthase 1 (CRLS1) gene, which encodes a mitochondrial phospholipid synthase, showed a similar regulatory effect. Thus, miR-22-3p and CRLS1 showed opposite effects in modulating lipid metabolism, which probably involved mitochondrial control. In summary, this study demonstrated that curcumin improved hepatic lipid metabolism via targeting the miR-22-3p/CRLS1 pathway. Identification of the epigenetic regulatory mechanism underlying lipid metabolism may thereby facilitate alleviation of metabolic disorders by natural polyphenols.
    Źródło:
    Polish Journal of Food and Nutrition Sciences; 2024, 74, 1; 59-68
    1230-0322
    2083-6007
    Pojawia się w:
    Polish Journal of Food and Nutrition Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Characterized Microstructure and Electrical Properties of Hydrogenated Nanocrystalline Silicon Films by Raman and Electrical Conductivity Spectra
    Autorzy:
    Xiao-Yong, Gao
    Jian-Tao, Zhao
    Yu-Fen, Liu
    Qing-Geng, Lin
    Yong-Sheng, Chen
    Jin-Hua, Gu
    Shi-E, Yang
    Jing-Xiao, Lu
    Powiązania:
    https://bibliotekanauki.pl/articles/1808127.pdf
    Data publikacji:
    2009-03
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    71.23.Cq
    73.61.-r
    Opis:
    Microstructure and electrical properties of hydrogenated nanocrystalline silicon (nc-Si:H) film deposited on glass substrate at low temperature were characterized by average grain size, crystallinity, and dark electrical conductivity data obtained from the Raman and electrical conductivity spectroscopy, respectively. The average grain size, crystallinity and electrical conductivity have a similar change with substrate temperature. A threshold substrate temperature determined by silane concentration appears in their corresponding spectroscopy vs. substrate temperature. The dependence of crystallinity, average grain size and electrical conductivity on substrate temperature were accounted for by surface diffusion model and heterojunction quantum dot model, respectively.
    Źródło:
    Acta Physica Polonica A; 2009, 115, 3; 738-741
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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