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    Wyświetlanie 1-8 z 8
    Tytuł:
    Nowe kierunki badań i wyzwania w analizie leków heparynowych
    New directions of research and challenges in the analysis of heparin drugs
    Autorzy:
    Sadowski, Radosław
    Krysztofiak, Dominika
    Gadzała-Kopciuch, Renata
    Buszewski, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/1413253.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    technika rozdzielania
    chromatografia cieczowa
    leki przeciwzakrzepowe
    heparyny
    LMWHs
    separation technique
    liquid chromatography
    anticoagulants
    heparin
    Opis:
    The complexity of the structure of heparin anticoagulants requires appropriate sample preparation to be able to perform the analysis correctly. This stage of the analytical procedure is the most time-consuming and has a key impact on the obtained information. Therefore, it is important to improve the current and search for new solutions for the preparation of samples of anticoagulants as well as the separation and identification of components of such drugs. This paper discusses heparin drugs and new research directions and challenges related to the analytics of heparin anticoagulants.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 935-942
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Propozycje innowacyjnych sorbentów w przygotowaniu próbek biologicznych
    Proposals of innovative sorbents in the preparation of biological samples
    Autorzy:
    Pajewska-Szmyt, Martyna
    Gadzała-Kopciuch, Renata
    Buszewski, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/1413237.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    metody przygotowania próbki
    dyspersyjna ekstrakcja do fazy stałej
    próbki biologiczne
    polimery z odciśniętą cząsteczką
    sample preparation method
    dispersive solid phase extraction
    biological sample
    molecularly imprinted polymers
    Opis:
    The sample preparation stage is a critical step in the whole analytical procedure as it often determines the efficiency of the process. What is particularly noticeable in the area of biological samples. Blood, milk, urine, saliva or tissue are only few examples of complicated biological matrix, that require a optimization of sample pre-treatment method for particular analytes. For these purpose, the aim of following chapter was to characterized main problems with sample preparation method as well as highlighted some innovative ways how to improve sample preparation stage. Attention was particularly focused on the use of dispersive solid phase extraction (dSPE), which has achieved high growth in interest in recent years, mainly due to the simplicity and rapidity of performance. This method is not only used with commercially available sorbents, but also provides a basis for trying to apply new analytical tools for separation of analytes from matrix. Following the trends of nanotechnology and within the rules of green analytical chemistry, scientists are facing the challenges of determining and identifying compounds from various chemical groups. Frequently targeting analytes at trace concentration levels as well biological samples. In addition, attention is also focused on reagents reduction and shorter analysis time but also in terms of minimization of sample volume, which should to be collected. Herein the chapter presented describes exemplary new proposals in sorbents such as molecularly imprinted polymers (MIPs), supported ionic liquids (ILs), dendrimers and metal-organic framework (MOFs). In addition, it also looked at the potential use of magnetic nanoparticles as carriers. New sorbents in sample preparation together with modem instrumental techniques therefore allow the development of a procedure that will be characterized by high selectivity and specificity.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 1075-1088
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oddech codzienny
    Daily breath
    Autorzy:
    Ligor, Tomasz
    Rudnicka, Joanna
    Ratiu, Ileana Andreea
    Monedeiro, Fernanda
    Monedeiro-Milanowski, Maciej
    Buszewski, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/1413274.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    analiza wydychanego powietrza
    lotne związki organiczne
    biomarkery
    chromatografia gazowa
    spektrometria mas
    breath analysis
    volatile organic compounds
    biomarkers
    gas chromatography
    mass spectrometry
    Opis:
    The odor of human body has facilitated diagnosis for a long time. Sniffing the body, breath, urine and even feces became one of the useful methods in ancient medicine. For centuries, the sweet smell of the breath was associated with diabetes, the fishy smell was associated with liver disease, measles was associated with the smell of feathers, typhoid with the smell of fresh bread, and tuberculosis with stale beer. Hippocrates also linked the smell of the human body and disease, claiming that the smell of a sick person is different from that of a healthy one. He classified the characteristic odors of the body into sweet, musty, fishy and rotten. The father of chemical analysis of breath was Antonie Lavoisier, who found that carbon dioxide is exhaled by guinea pigs. The pioneer of modem breath analysis was Linus Pauling, who in 1971 presented the results of breath studies using gas chromatography (GC), showing the presence of over 200 substances. Exhaled air containing approximately 78% N2, 17% O2, 3% CO2 and up to 6% water vapor. The exact concentrations of individual inorganic gases depend on many factors, mainly physical exercise, cardiac output, and lung ventilation. A mixture of many volatile organic compounds is a much smaller group of substances at concentrations 100 ppm. The substances in the breath can come from human metabolism and enter into the body by inhaled air and food. Volatile organic compounds present in the breath that can be divided into different chemical classes e.g. saturated hydrocarbons (ethane, pentane, aldehydes), unsaturated hydrocarbons (isoprene), ketones (acetone), sulfur-containing compounds (methyl mercaptan, dimethyl sulfide, dimethyl disulphide, carbon disulphide, carbonyl sulphide) and containing nitrogen (amines). Endogenous substances in the breath can be used to track physiological and pathological processes in the body. Chemical analysis of the breath can provide information regarding biochemical processes in the organism and human health. Compared to many medical diagnostic methods, it is painless, non-invasive and safe. Nowadays, the main purpose of breath analysis is to identify volatile organic compounds that can be used as markers of various diseases. Research focused on detection of lung cancer based on specific volatile organic compounds in the exhaled air is carried out in many laboratories. Rapid and non-invasive methods for early detection of lung cancer and chronic obstructive pulmonary disease is crucial for early diagnosis. This mini review presents background of breath, briefly describes main volatiles, their biochemical origin as well as potential application of exhaled gases analysis.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 911-922
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Surowce roślinne i produkty naturalne : nowe nadzieje dla przyszłych pokoleń
    Plant materials and natural products : new hopes for the future generations
    Autorzy:
    Ligor, Magdalena
    Rafińska, Katarzyna
    Wrona, Olga
    Kiełbasa, Anna
    Krakowska-Sieprawska, Aneta
    Buszewski, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/1413277.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki biologicznie aktywne
    ekstrakcja
    analiza ekstraktów roślinnych
    biologically active compounds
    extraction
    analysis of plant extracts
    Opis:
    The one of the many scientific tasks carried out in Department of Environmental Chemistry and Bioanalytics is the development of methodologies concern antioxidant properties and biological activity of compounds (mainly cyclitols, fatty acids, flavonoids, polyphenolic acids and saponins) separated from raw plant materials and natural products. Such investigations, in general important for human health, was carried out as part of the project entitled: Cultivated plants and natural products as a source of biologically active substances assign to the production of cosmetic and pharmaceutical products as well as diet supplements, attributed by the National Center for Research and Development (2016-2021). The aim of the project was to develop a strategy for the comprehensive use of native plant materials and dissemination of valuable herbal plants in various industries, with particular emphasis on cosmetics, medical devices, dietary supplements, and as livestock feed and a source of biomass. Another important aspect was/is the use of the local potential of plant cultivation, taking into account the Polish production of plant material (limitation of import). Selected plant materials will be both nutritional value and the presence of biologically active ingredients, as well as treating the plant biomass as a renewable source of energy. The proposed technological solutions are located in the area of "green chemistry", an important aspect for the proecology. The plant materials which meet the aforementioned criteria and due to the presence of important active ingredients are: lucerne (Medicago sativa L.), liquorice (Glycyrrhiza glabra), Lepidium sativum and goldenrod (Solidago sp.), buckwheat (Fagopyrum esculentum), fenugreek (Trigonella foenum-graecum), rape and kale, lacy phacelia, (Phacelia tanacetifolia Benth.) as well as camelina (Cornelina sativa L.). An implementation of the proposed research project was proceeded in different directions, based on the cooperation of research institutions with cosmetics and pharmaceutical industries, herbs and beekeepers from across Poland.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 961-980
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analityka antybiotyków β-laktamowych w układzie in silico, in vitro oraz in vivo
    Analytics of beta-lactam antibiotics in silico, in vitro and in vivo
    Autorzy:
    Janiszewska, Daria
    Szultka-Młyńska, Małgorzata
    Buszewski, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/2086736.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki biologicznie aktywne
    techniki chromatograficzne
    elektrochemia
    in vitro
    in vivo
    spektrometria mas
    metabolizm
    monitorowanie leków
    biologically active compounds
    chromatographic techniques
    electrochemistry
    mass spectrometry
    metabolism
    drug monitoring
    Opis:
    Drug analysis necessitates introducing selective methods of detection and enriching the substances present in biomaterial at low concentration levels (trace analysis). Moreover, there is a continuous demand for increase in the quality of drugs that are being developed, which in turn enforces the development of analytical techniques of increasing sensitivity and accuracy with the applicationof combined separation techniques. Thus the premise of this review is to comparethe in vitro metabolic pathways of antibiotic drugs in model conditions such as in the presence of different microsomal fraction enzymes and with the applicationof electrochemical stimulation of metabolic transformations, as well as to the collected data with the results of in vivo experiments.
    Źródło:
    Wiadomości Chemiczne; 2022, 76, 3-4; 109--127
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Kapilarne ogniskowanie izoelektryczne w analizie białek mleka
    Capillary isoelectric focusing in the analysis of milk protein
    Autorzy:
    Janiszewska, Daria
    Szultka-Młyńska, Małgorzata
    Pomastowski, Paweł
    Buszewski, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/1413252.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    biokoloidy
    elektroforeza kapilarna
    izoelektryczne ogniskowanie kapilarne
    białka mleka
    biocolloids
    capillary electrophoresis
    isoelectric capillary focusing
    milk proteins
    Opis:
    The analysis of milk and dairy products is essential during production, quality control, and understanding the factors that cause food allergies. Milk is one of many examples of biocolloids. Numerous studies show that capillary electrophoresis and capillary isoelectric focusing is an excellent tool for this type of analysis. In addition, the coupling of these techniques with other analytical methods such as MALDI-TOF MS or ESI-MS enables the improvement of the quality of analyzes, allows the separation of proteins close to the isoelectric point values. This short overview summarizes the possibilities of using electromigration techniques in the proteomic and microbiological analysis of milk and milk products.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 943-957
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zastosowanie technik laserowej desorpcji/jonizacji w identyfikacji lipidów jako biomarkerów raka prostaty
    Application of laser desorption/ionization techniques in the identification of lipids as prostate cancer biomarkers
    Autorzy:
    Buszewska-Forajta, Magdalena
    Pomastowski, Paweł Piotr
    Maślak, Ewelina
    Fijałkowski, Piotr
    Buszewski, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/1413254.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    laserowa desorpcja/jonizacja
    LDI
    lipidy
    biomarker
    rak prostaty
    laser desorption/ionization
    lipids
    prostate cancer
    Opis:
    Mass spectroscopy has grown enormously over the past century and its variations are used in many fields. One of the methods used to ionize particles is to irradiate the sample with laser radiation. This methods are called laser desorption/ionization techniques and they have great potential for diagnostic applications. Thanks to the so-called soft ionization, direct analysis of a wide variety of compound classes can be used for rapid profiling. Lipids are a diverse group of metabolites that share a common feature of having a hydrophobic fragment. They play an important role in various cellular processes. Changes in lipidome correlate with the symptoms of various diseases. The observation of abnormalities in lipid metabolism is especially important in cancers diagnosed in many patients - such as prostate cancer. Monitoring the level of key biomarkers in the development of a given disease will allow for an earlier correct diagnosis and the use of individual treatment. This short review presents the issues of prostate cancer and the applicability of laser desorption/ionization techniques to identify lipid biomarkers that can be used for rapid identification.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 893-909
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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