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    Wyświetlanie 1-71 z 71
    Tytuł:
    Trastuzumab-dendrimer-fluorine drug delivery system
    Autorzy:
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/895535.pdf
    Data publikacji:
    2020-04-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    trastuzumab
    Dendrimer
    Drug delivery system
    Her-2 receptor
    Opis:
    Breast cancer is the most frequently occurring cancer in women worldwide with more than one million new cases diagnosed each year. The objective of this study was to develop a Trastuzumab-dendrimer-fluorine drug delivery system by covalent attachment of Trastuzumab to a fluorinated PAMAM-G5 dendrimer. The Trastuzumab-dendrimer-fluorine drug delivery system was used to treat MCF-7 with Her-2 overexpression. The use of PAMAM-G5, which bears 128 primary amine surface groups, enables covalent attachment of both antibody and fluorinated functional groups for enhancement of cellular uptake. Thus, Trastuzumab was covalently attached to fluorinated PAMAM-G5 dendrimers and used as a vehicle for drug delivery to three dimensional (3D) cultured cells. The efficiency of Trastuzumab-dendrimer-fluorine drug delivery system binding to Her-2 receptors was measured by cell viability. The Trastuzumab-dendrimer-fluorine drug delivery system was found to have a higher efficiency in the treatment of Her-2 overexpressing MCF-7 cells than Trastuzumab alone. The incorporation of 19F by addition of heptafluorobutyric acid anhydride (HFAA) to PAMAM-G5 increased lipophilicity and hydrophobicity of drug delivery system.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 331-341
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena przydatności średniopolowych systemów MR w obrazowaniu hodowli komórkowych
    Assessment of the usefulness of medium-field MR systems in imaging of cell cultures
    Autorzy:
    Truszkiewicz, Adrian
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/985832.pdf
    Data publikacji:
    2020
    Wydawca:
    Indygo Zahir Media
    Tematy:
    rezonans magnetyczny
    mikroskopia MRI
    hodowle komórkowe
    magnetic resonance imaging
    MRI microscopy
    cell cultures
    Opis:
    W niniejszym artykule autorzy podjęli próbę oceny przydatności systemów rezonansu magnetycznego o sile 1,5 Tesla do obrazowania małych struktur, jakimi są hodowle komórkowe. Zakres obrazowania, jaki stał się przedmiotem badań, wkracza w obszar będący domeną mikroskopii rezonansu magnetycznego (MRM). W dzisiejszej dobie badania te wykonywane są przy użyciu systemów wysokopolowych zapewniających dużo większe rozdzielczości przestrzenne. Celem pracy było określenie warunków, jak również parametrów skanowania pozwalających na obrazowanie małych obiektów przy wykorzystaniu systemu OPTIMA MR360 produkcji GE Healthcare. W wyniku prac koniecznym stało się opracowanie dodatkowej cewki solenoidalnej, której to zarówno wymiary, kształt, jak i konstrukcja zapewniły optymalną jakość obrazowania możliwą do uzyskania w oparciu o w/w system MR. Artykuł ten jest pierwszym z serii prac ukazujących badania hodowli komórkowych z użyciem rezonansu magnetycznego w Uniwersytecie Rzeszowskim.
    In this article, the authors attempt to assess the usefulness of 1,5 Tesla magnetic resonance imaging systems for imaging of small structures such as cell cultures. The scope of imaging that has become the subject of research enters the area that is the domain of magnetic resonance microscopy (MRM). Nowadays, these tests are performed using high-field systems providing much higher spatial resolutions. The purpose of the work was to determine the conditions as well as scanning parameters that allow imaging of small objects using the OPTIMA MR360 production system. GE Healthcare. As a result of the work, it became necessary to develop an additional solenoid coil, which both dimensions, shape and design ensured optimal imaging quality possible based on the above MR system. This article is the first in a series of works showing the study of cell cultures using magnetic resonance imaging at the University of Rzeszów.
    Źródło:
    Inżynier i Fizyk Medyczny; 2020, 9, 1; 37-40
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Termometria rezonansu magnetycznego
    Thermometry of magnetic resonance
    Autorzy:
    Truszkiewicz, Adrian
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/985931.pdf
    Data publikacji:
    2019
    Wydawca:
    Indygo Zahir Media
    Tematy:
    czas relaksacji
    pomiar temperatury
    termometria
    MRI
    termoterapia
    PFR
    rezonans magnetyczny
    magnetic resonance imaging
    temperature measurement
    thermometry
    thermotherapy
    Opis:
    Odkryte w połowie XX wieku zjawisko rezonansu magnetycznego stanowi do dnia dzisiejszego potężne narzędzie w rękach badaczy. Znajduje zastosowanie zarówno w naukach biologicznych, jak i technicznych. Sztandarowym zastosowaniem metody obrazowania wykorzystującego zjawisko rezonansu magnetycznego jest medycyna. Ta w pełni nieinwazyjna metoda pozwala na badanie ludzkiego ciała w sposób dotąd niespotykany. Niniejsza praca prezentuje jeden z aspektów zastosowania tej metody, a mianowicie termometrię rezonansu magnetycznego (MRT). W pracy dokonano przeglądu metod pozwalających na monitorowanie temperatury metodą MRI. Pokazano źródła błędów, jak również wybrane metody ich redukcji. Cel pracy. Celem pracy jest przedstawienie metod pomiaru temperatury wnętrza ludzkiego ciała metodami MRI. Termometria MRI (MRT) to ważna funkcjonalność pozwalająca na nieinwazyjne mierzenie temperatury w miejscach o ograniczonym dostępie. Funkcjonalność ta jest nieodzowna w prowadzeniu niektórych rodzajów terapii nowotworów. Znajomość rozkładu temperatur nie tylko w punkcie, ale w całej objętości jest kluczowa do tego rodzaju zastosowań.
    The phenomenon of magnetic resonance imaging discovered in the mid-20th century is a powerful tool to this day in the hands of researchers. It finds application in both sciences biological and technical. The main application field of the resonance phenomenon is medicine. The method is completely non-invasive and allows the examination of the human body in a manner so far unparalleled. This work presents one aspect of the application of this methods, called magnetic resonance imaging thermometry (MRIT). The paper reviews methods allowing for temperature monitoring. Error sources as well as selected methods of their reduction is presented. Objective of the work. The purpose of the work is to present methods for the measurements of internal body temperature by MRI . Thermometry MRI (MRIT) is an important field that allows non-invasive temperature measurement. This functionality is indispensable in driving certain types of cancer therapy. Knowledge of the temperature is crucial for this application.
    Źródło:
    Inżynier i Fizyk Medyczny; 2019, 8, 5; 385-389
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anticancer properties of Viburnum
    Autorzy:
    Stępień, Agnieszka
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454949.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    antitumor activity
    Viburnum species
    cytotoxic activity
    Opis:
    Aim. The aim of this paper is to provide an overview of the anticancer properties of different species of Viburnum. Materials and methods. Forty nine papers that discuss the medicinal history and current research of Viburnum species as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research conducted in vitro indicate that the compounds present in the extracts of Viburnum significantly affect the development of cancer cells such as leukemia, cervical cancer, breast, colon, lung, skin and stomach. This indicates that they may be used as a therapeutic agent to support oncological therapies.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 47-52
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    MRI as a potential tool for monitoring of therapeutic monoclonal antibody distribution in cancer patients
    Autorzy:
    Tabarkiewicz, Jacek
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/895617.pdf
    Data publikacji:
    2020-06-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    monoclonal antibody
    magnetic resonance imaging
    fluorine
    cancer diagnostics
    Opis:
    Imaging and quantification of MAbs distribution by MRI after administration in vivo can improve patient outcomes, although it is not routinely used in the clinic hence the motivation for development of new MAbs imaging methodologies. Improvements in imaging and quantification of antibody distributions can be made by conjugating MAbs to “hotspot” atoms such as 19F as 19F Currently, research investigating the incorporation of 19F to antibody delivery systems has been limited to trastuzumab perfluorocarbon emulsions and this method has not been extended to other clinically approved antibodies. The methodologies of 19F MRI can improve current limitations of antibody immunotherapy such as quantitative visualization of targeted surface antigens expressed on tumor cells.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 383-389
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Spektroskopia MRS w hodowlach komórkowych in vitro
    In vitro MRS spectroscopy of cell cultures
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2146759.pdf
    Data publikacji:
    2020
    Wydawca:
    Indygo Zahir Media
    Tematy:
    Spektroskopia Rezonansu Magnetycznego
    MRS
    hodowle komórkowe
    Magnetic Resonance Spectroscopy
    cell cultures
    Opis:
    Magnetyczny Rezonans Spektroskopowy (MRS) mimo swojej siedemdziesięcioletniej historii jest dziedziną ulegającą stałemu i niesłabnącemu rozwojowi. Wiąże się to z możliwością wszechstronnego wykorzystania pomiarów MRS zarówno eksperymentalnie do badań podstawowych z zakresu biochemii i fizyki (wyznaczania pewnych parametrów kinetycznych i termodynamicznych), jak i klinicznie w praktyce medycznej. Jako obiekt badań wybrane zostały hodowle komórkowe, a wyniki badania spektroskopowego w hodowlach komórek nowotworowych są prezentowane w niniejszym opracowaniu. Celem pracy była optymalizacja pomiaru spektroskopowego w hodowlach komórkowych na średniopolowym systemie magnetycznego rezonansu jądrowego. Zapotrzebowanie na jakościowe i ilościowe analizy zawartości aminokwasów w mediach i różnych płynach fizjologicznych i poznanie składu mieszanin aminokwasów białek spowodowało rozwój wielu technik spektroskopowych, m.in. MRS.
    Magnetic Resonance Spectroscopy (MRS), despite its seventy years of history, is a field undergoing constant and uninterrupted development. This involves the possibility of comprehensive use of MRS measurements both experimentally for basic research in the field of biochemistry and physics (determination of certain kinetic and thermodynamic parameters) as well as clinically in medical practice. Cell cultures were chosen as the object of research and the results of spectroscopic examination in cancer cell cultures are presented in this study. The aim of the work was to optimize spectroscopic measurement in cell cultures on a medium-field nuclear magnetic resonance system. The need for qualitative and quantitative analysis of the content of amino acids in the media and various physiological fluids and knowledge of the composition of amino acid mixtures of proteins has resulted in the development of many spectroscopic techniques, among others MRS.
    Źródło:
    Inżynier i Fizyk Medyczny; 2020, 9, 3; 175--178
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Selected applications of fluorinated MR contrast agents and fluorine-containing drugs in medicine
    Autorzy:
    Bartusik-Aebisher, Dorota
    Bober, Zuzanna
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/895525.pdf
    Data publikacji:
    2020-06-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    drug delivery
    drug design
    19F MRI
    19F MRS
    drug efficacy
    Opis:
    This review aims to present magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) for applications in cellular therapeutics including descriptions of the use of 19F MRI and 19F MRS in drug tracking and visualization. Both MRI and MRS are often used as diagnostic tools in oncology, are non-invasive, and also can be employed for monitoring non-oncological and oncological therapies. Herin, we provide information pertaining to tracking and visualization of fluorinated drug uptake in cancer tissue in vitro, in vivo and ex vivo. The response of tissue to treatment is also discussed.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 403-410
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biological properties of Cistus species
    Autorzy:
    Stępień, Agnieszka
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454751.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    biological properties
    Cistus sp.
    medicinal plants
    Opis:
    Aim. This paper presents a review of scientific studies analyzing the biological properties of different species of Cistus sp. Materials and methods. Forty papers that discuss the current research of Cistus sp. as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research indicate that extracts from various species of Cistus sp. exhibit antioxidant, antibacterial, antifungal, anti-inflammatory, antiviral, cytotoxic and anticancer properties. These properties give rise to the possibility of using Cistus sp. as a therapeutic agent supporting many therapies
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 27-132
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of MRI in the central nervous system
    Autorzy:
    Leksa, Natalia
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454852.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    1H MRI
    functional MRI
    metabolic brain disfunctions
    Opis:
    Introduction. Magnetic Resonance Imaging (MRI) has modified the practice of radiology. MRI is base on safe interaction between radiowaves at a particular frequency and hydrogen nuclei in the body. Metabolic encephalophaties are by definition those disorder of the central nervous system that are not due primarily to structural abnormalities. Aim. Here we present the 1H MRI and functional MRI (fMRI) method applied to diagnosis of disorders of the central nervous system. Material and methods. Analysis of literature and self-research. Results.We have discussed the major MRI applications in the characteristic of the central nervous system. The relationship beteen the motion of flowing blood and the representation of the blood on images is complex. This work is an introduction to the basic ideas and techniques of fMRI. Therefore, both, 1H MRI and functional MRI, methods are ued in neuroscience. Conclusion. Nonivasive MRI and functional MRI are daily diagnostics methods in neurology.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 28-31
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Składowe ośrodka jako czynnik zakłócający wynik pomiaru czasu relaksacji T1
    The influence of medium components as a factor disturbing the result of the measurement of the relaxation time T1
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2146785.pdf
    Data publikacji:
    2020
    Wydawca:
    Indygo Zahir Media
    Tematy:
    rezonans magnetyczny
    relaksacja podłużna
    relaksacja poprzeczna
    czas relaksacji
    magnetic resonance imaging
    longitudinal relaxation
    lateral relaxation
    relaxation times
    Opis:
    Niniejsza praca ukazuje jedno z wybranych źródeł błędów, jakie znacznie powiększają niepewność wyniku określania czasu T1. Autorzy skupili się na wpływie ośrodka, w którym znajduje się badany obszar, na wartość czasu relaksacji. Pokazano na przykładzie fantomu, jak może się zmieniać wartość mierzonego parametru w zależności od właściwości składowych ośrodka. Założeniem każdej tomografii pozwalającej na obrazowanie dowolnych obiektów ze skończoną rozdzielczością przestrzenną jest to, iż piksel na całej swej powierzchni ma jednakową gęstość czy też skład chemiczny. W znakomitej większości przypadków jest to daleko posunięte uproszczenie, które pominięte w czasie analizy może doprowadzić do bardzo poważnych błędów interpretacji wyników prowadzonej diagnostyki czy też bardziej ogólnie badań.
    This paper shows one of the selected sources of errors that significantly increase the uncertainty of the result of determining the time T1. The authors focused on the influence of the center in which the studied area is located on the value of the relaxation time. It was shown on the example of a phantom how the value of the measured parameter can change depending on the properties of the medium components. The assumption of each tomography that allows imaging of any objects with finite spatial resolution is that the pixel has the same density or chemical composition on its entire surface. In the vast majority of cases, it is a far-reaching simplification which, omitted during the analysis, may lead to very serious errors in the interpretation of the results of the diagnostics or, more generally, tests.
    Źródło:
    Inżynier i Fizyk Medyczny; 2020, 9, 6; 391--395
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neoadjuvant therapy in breast cancer – objectives and tasks
    Autorzy:
    Ostańska, Elżbieta
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454710.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    neoadjuvant therapy (NCT)
    breast cancer (BC)
    triple negative breast cancer (TNBC)
    Opis:
    Introduction. Neoadiuvant therapy (NCT) in the treatment of breast cancer is employed for patients with early stage disease or with inoperable disease. NCT can decrease the tumor volume. It can facilitate breast conservation therapy. Response to NCT is a strong predictor of outcome breast cancer (BC). Direct target therapies has markedly improved the result of treatment BC. Aim. Therapy for breast cancer continues to improve. The importance of tumor burden on local control rates will be in the future. Material and methods. This analysis was performed using a systematic literature search. Results. The latest scientific reports give hope for greater safety and a better life for patients based on optimized and effective therapy. Conclusion. Currently, improving the effectiveness of breast cancer treatment is mainly related to the optimal use of classic therapeutic strategies. New classes of substances have been approved for treatment or are in advanced stages of clinical development.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 153-156
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inflammatory bowel disease: the function of metalloproteinases
    Autorzy:
    Pasternak, Grzegorz
    Aebisher, David
    Filip, Rafał
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454718.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    inflammatory bowel disease
    matrix metalloproteinases extracellular matrix
    Opis:
    Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. Materials and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases. Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis. Conclusions. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 346-349
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Medicinal & Aromatic Plants
    Autorzy:
    Domka, Wojciech
    Aebisher, David
    Truszkiewicz, Adrian
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454771.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    phytotherapy
    medicinal plants
    otorhinolaryngology
    Opis:
    Introduction. The objective of this study is to discuss the potential of plants species in medical applications. Aim. The main purpose of this study is to discuss ethnobotanically selected plants used in medicine. Materials and methods. We analysed literature and collected information, data, and examples of selected plants used in medicine. Results. The literature shows that for several decades, the properties of medicinal plants have been investigated and reported in the biomedical and pharmaceutical literature. Conclusions. This review includes studies on plants material. The properties of various plants physiology were discuuses with the option for the use in phythotherapy
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 350-358
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Imaging methods of early detection and screening for breast cancer. A review
    Autorzy:
    Gustalik, Joanna
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454888.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast cancer
    breast MRI
    early detection
    screening
    Opis:
    Introduction. Breast cancer is the most frequent neoplasm among women. That is the reason why scientists all over the world are attempting to improve early detection methods of this particular malignancy. Aim. The most common and most widely used examination methods for screening for and detecting breast cancer is presented herein. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases. Results. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. Conclusion. The role of a physician is to select the most suitable one for each patient in order to obtain the best result. No matter the method however, between 2005 and 2011, the 5-year relative survival was found to be 89%. This is thought to be due to both the increase in utilization of population-wide screening, as well as advances in treatment.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 142-145
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bladder Mullerianosis – a case report
    Autorzy:
    Ostańska, Elżbieta
    Aebisher, David
    Kaznowska, Ewa
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454913.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    endocericosis
    endosalpingiasis
    mullerianosis
    urinary bladder
    Opis:
    Introduction. Bladder mullerianosis is a rare and proliferative lesion that contains at least two types of ectopic Mullerian tissue in its wall. Aim. To present case of bladder mullerianosis. Description of case. The text contains a description of a clinical case of a 50-year-old woman admitted to a gynecological ward due to diarrheal symptoms and abdominal pain. In a CT examination of the abdominal cavity with contrast, within the posterior left-sided wall of the bladder a 43x25mm proliferative lesion suggestive of neoplastic character was revealed. Transurethral resection of the lesion (TURB) was performed. Histopathology revealed endosalpingiosis with small endocervical foci. The picture of hyperplasia met the criterion of mullerianosis. Conclusion. Bladder Mullerianosis is a very rare disease that occurs mainly in women of reproductive age. It has very good prognosis. It is important to differentiate the lesion with malignant tumor. The basis for the diagnosis is the histopathological examination of the lesion tissues taken during the surgery.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 277-280
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hyalinising clear cell carcinoma of salivary gland: a case report
    Autorzy:
    Osuchowski, Michał
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2037686.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cancer
    hyalinising clear cell carcinoma salivary gland
    Opis:
    Introduction. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland (HCCC) is a malignancy that arises in minor salivary glands. It rarely leads to distant metastases or cancer-related death but has the potential for recurrence and focal metastases. Aim. A case is reported. Description of the case. A 72 years old female patient has reported to the Clinic of Otolaryngology with a tongue lesion. The patient had no history of malignancy. The lymph node has been surgically removed for further examination. Cords and nests of clear cells and cells with eosinophilic cytoplasm in a hyalinized stroma were identified within the lymph node. After the diagnosis the patient has been transferred to another Oncology Hospital for further treatment. Conclusion. The diagnosis of clear cell carcinoma may be challenging because many of it‘s features frequently overlap with other salivary gland lesions.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 2; 127-130
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The larynx cancer in vitro study by MRI relaxtion time of water
    Autorzy:
    Domka, Wojciech
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2038279.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    larynx tissue
    magnetic resonance imaging
    T2 mapping
    T2 relaxation time
    Opis:
    Introduction. Squamous cell carcinoma (SCC) of the larynx accounts for a significant percentage of all head and neck cancers. Aim. In this paper we determine the differences in magnetic resonance relaxation time (MRI) of water in cancerous and healthy larynx tissues. Material and methods. This study is aimed on T2 MRI modalities for monitoring morphology of larynx tissue. Results. Our results showed that T2 MRI relaxation time measured in larynx tissue can be used to assess early cancer condition of larynx tissues. The changes of T2 MRI correspond to tumor growth within normal tissue. Conclusion. The study showed potential of MRI for the non-invasive monitoring of larynx condition.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 185-187
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Primary breast angiosarcoma – a case report
    Autorzy:
    Ostańska, Elżbieta
    Aebisher, David
    Kaznowska, Ewa
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2040145.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast biopsy histopathological examination
    immunohistochemistry
    Opis:
    Introduction. Angiosarcoma is a rare breast cancer that can be primary or secondary after surgery or after breast cancer radiotherapy. It is important that breast angiosarcoma belongs to tumors with a non-specific clinical and radiological picture. Aim. The study of the biopsies contained aggressive vasomotor hyperplasia. Description of the case. The presented case concerns the primary angiosarcoma of the right breast in a 56-year-old woman who had never had a surgical procedure before, nor radiotherapy in the area of the breast. Conclusion. Histopathological examination supported by immunohistochemistry is a reliable and indispensable diagnostic element in the diagnosis of vascular sarcoma.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 4; 331-334
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Paradygmaty w fMRI
    Paradigms in fMRI
    Autorzy:
    Leksa, Natalia
    Truszkiewicz, Adrian
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2146758.pdf
    Data publikacji:
    2020
    Wydawca:
    Indygo Zahir Media
    Tematy:
    fMRI
    paradygmaty
    funkcjonalny rezonans magnetyczny
    paradigms
    functional magnetic resonance imaging
    Opis:
    Funkcjonalny Rezonans Magnetyczny (fMRI) jest nieinwazyjną techniką badawczą, która daje wgląd w procesy zachodzące w mózgu pacjenta. Przy jego pomocy ocenia się zarówno miejsca odpowiedzialne za motorykę, jak i funkcje poznawcze. Ta metoda badawcza oparta o własności magnetyczne oksyhemoglobiny i deoksyhemoglobiny zapewnia identyfikacje ośrodków mózgowia w sposób do tej pory niemożliwy. Jej stosowanie jest ważne nie tylko w procesie poznawczym, ale również w procesie leczenia, w szczególności w procesie przygotowywania pacjentów do zabiegów operacyjnych. FRMI należy do diagnostyki szczególnie wymagającej współpracy ze strony pacjenta, ponieważ najczęściej musi on realizować zadania narzucone przez personel badający. To właśnie od właściwego zaprojektowania tychże zadań i schematu czasowego ich realizacji i oceny wyników zależy właściwa diagnostyka. Celem niniejszej pracy jest prezentacja wybranych paradygmatów stosowanych w FMRI.
    Functional Magnetic Resonance Imaging (fMRI) is a non-invasive research technique that gives insight into the processes in the patient’s brain. With its help, both the places responsible for motor skills and cognitive functions are assessed. This research method based on the magnetic properties of oxyhemoglobin and deoxyhemoglobin ensures identification of brain centers in a way that has not been possible so far. FRMI use is important not only in the cognitive process, but also in the treatment process, in particular in the process of preparing patients for surgery. FRMI belongs to the diagnostics particularly demanding cooperation on the part of the patient, because he most often has to carry out tasks imposed by the research staff. It is the proper design of these tasks and the time schedule of their implementation and evaluation of results that determine the correct diagnosis. The purpose of this work is to present selected paradigms used in FMRI.
    Źródło:
    Inżynier i Fizyk Medyczny; 2020, 9, 2; 109--112
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Perspektywy badań mózgowia z wykorzystaniem MRI
    Prospects for brain research using MRI
    Autorzy:
    Truszkiewicz, Adrian
    Dynarowicz, Klaudia
    Bartusik-Aebisher, Dorota
    Cholewa, Marian
    Powiązania:
    https://bibliotekanauki.pl/articles/985830.pdf
    Data publikacji:
    2020
    Wydawca:
    Indygo Zahir Media
    Tematy:
    rezonans magnetyczny
    sekwencje
    badanie OUN
    magnetic resonance imaging
    sequences
    CNS examination
    Opis:
    Rezonans magnetyczny (MRI) zmodyfikował praktykę radiologii w dziedzinie badań mózgowia. Technika ta opiera się na bezpiecznej interakcji pomiędzy falami radiowymi o określonej częstotliwości i jądrami wodoru w ciele człowieka lub w innym badanym obiekcie. Szczególny postęp zaobserwowano w badaniach ilościowych i jakościowych metabolitów, które z definicji nie są zaburzeniami ośrodkowego układu nerwowego i które nie są spowodowane nieprawidłowościami strukturalnymi, dlatego występują endogennie w niewielkich ilościach. W pracy przedstawiono pogląd na obecne wykorzystanie MRI w badaniach mózgowia.
    Magnetic resonance imaging (MRI) has modified radiology in the field of brain research. This technique is based on the safe interaction between radio waves of a certain frequency and hydrogen nuclei in the human body or other object being tested. Particular progress has been observed in the quantitative and qualitative studies of metabolites which by definition are not disorders of the central nervous system, and which are not caused by structural abnormalities and therefore occur in small amounts enodogenously. The paper presents the view on the current use of MRI in brain research.
    Źródło:
    Inżynier i Fizyk Medyczny; 2020, 9, 1; 21-22
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Numerous gastrointestinal tumors
    Autorzy:
    Przyczyna, Piotr
    Trojnar, Elżbieta
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2040144.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    gastrointestinal stromal tumor histopathological examination multiple neoplasms
    small intestine
    Opis:
    Introduction. Gastrointestinal stromal tumor (GIST) is most often locate in the region of the stomach and the proximal part of the small intestine. Aim. The multiple histopathological examination is described. Description of the case. Multiple GISTs are rare neoplasms that originate from the interstitial cells are described. Conclussion. GIST can occur in any part of the gut, they are most common in the stomach and small intestine, and less frequent in the colorectum and esophagus. Although their pathogenesis and clinical manifestations are different, these tumor syndromes confer a high risk for developing multiple neoplasms.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 4; 328-330
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mixed adenocarcinoma-neuroendocrine cancer – a case report
    Autorzy:
    Gustalik, Joanna
    Aebisher, David
    Kaznowska, Ewa
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2040147.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    central nervous system
    MANEC
    mixed adenocarcinoma-neuroendocrine cancer
    Opis:
    Introduction. Mixed adenocarcinoma-neuroendocrine cancer (MANEC) is a rare cancer that is characterized by aggressive course and poor prognosis. Aim. A case report and literature review. Description of the case. This article presents the case of a 63-year-old patient who was hospitalized due to the occurrence of neurological symptoms such as nausea, dizziness and headache as well as double vision and numbness of the hands. Suspected ischemic stroke, meningitis with bacterial etiology or brainstem pathology. Conclusion. MANEC composed of large neuroendocrine cells have better survival and clinical behavior than patients with small, intermediate or mixed large and intermediate cells.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 4; 335-337
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of MR relaxation times following trastuzumab treatment of breast cancer cells in a 3D bioreactor
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Czmil, Anna
    Mazur, Damian
    Powiązania:
    https://bibliotekanauki.pl/articles/895234.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    magnetic resonance imaging (MRI)
    breast cancer cell cultures
    hollow-fiber bioreactor (HFBR)
    relaxation time maps
    Opis:
    The three dimensional tumor environment can be mimicked with the use of cells cultured within a hollow-fiber bioreactor (HFBR). In this work, magnetic resonance imaging (MRI) was used to monitor changes in relaxation time in breast cancer cells following treatment with Trastuzumab in a HFBR system. Breast cancer cells were inoculated into the HFBR system and cultured over a period of 4 weeks. Relaxation time maps were generated according to MRI techniques in three dimensional (3D) cultures of MCF7/Her2 breast cancer and MCF7/Neo4 control cells. MRI measurements showed a variation in values of spin-lattice (T1) and spin-spin (T2) relaxation times related to cell density. Differences in both values (T1 and T2) were noted between untreated cells and cells treated with trastuzumab in the HFBR device. Additionally, 1H MRI was able to provide information about drug penetration in breast cancer cell culture organized in 3D. In conclusion, MRI in vitro can provide direct, noninvasive visualization of cell density in 3D geometry and cell viability as a function of drug uptake. Both T1 and T2 values were higher for lower cell density and accordingly both values, T1 and T2, were lower for higher cell density.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 35-41
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The potential of Fluorine 19F in in Targeted Therapy
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Podgórski, Rafał
    Leksa, Natalia
    Powiązania:
    https://bibliotekanauki.pl/articles/895641.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    cancer
    drug delivery
    Drug Monitoring
    Fluorine-19
    Opis:
    Fluorine-19 (19F) can provides critical information about the mobility of the drug and drug uptake in cancer tissue when used together with 19F Magnetic Resonance Imaging (19F MRI) in vitro or in vivo. This review is aimed at the current limitations of drugs such as quantitative visualization during treatments of tumor cells. The main rationale about the utility of 19F MRI is visualization of fluorinated drug and fluorine conjugates on the cellular in vitro and in vivo levels.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 939-943
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Plant medicinal products and drug interactions
    Autorzy:
    Ożóg, Łukasz
    Aebisher, David
    Bober, Zuzanna
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454688.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    drug interactions
    natural products
    drug
    therapeutic material
    Opis:
    Introduction. Some herbal medicinal products may be beneficial in certain respects but many can be dangerous for patients taking doctor-prescribed medications. Plant medicinal products are often taken with conventional drugs by patients. Interactions are possible between herbal medicinal products and conventional medications that can lead to toxicity due to increaseddrug plasma levels or drug treatment failure. Aim. The aim of the study was to review the study of plant medicinal products and drug interactions. Materials and method. Analysis of literature.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 37-40
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Receiver operating characteristic analysis of the FeNO biomarker in the diagnosis of asthma
    Autorzy:
    Biesiadecki, Marek
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454725.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    asthma
    nitric oxide
    ROC curve
    Opis:
    Introduction. The fraction of exhaled nitric oxide (FeNO) is used as a non-invasive biomarker that reflects inflammation in the airways. It is so versatile that it used to control asthma severity as well as to monitor response to treatment. However, the exact cut-off point of the nitric oxide level which allows one to make a precise diagnosis of asthma is unclear. Aim. To examine the possibility of using advanced statistical methods such as receiver operating characteristic for the analysis of FeNO concentrations for improving the diagnosis of asthma. Materials and methods. Receiver operating characteristic (ROC) was used for analyzing results to determine levels of nitric oxide which may be a prognostic indicator of asthma. The studied group consisted of 111 children including 69 asthmatic patients, and 42 age- and sex-matched healthy subjects. Measurement of exhaled nitric oxide was conducted in all subjects included in this study. Results. FeNO level was higher in asthmatic patients. The analysis of results showed that the cut-off point for the FeNO concentration is 11.5 ppb. Sensitivity and specificity with the FeNO level allowed us to determine a value of the diagnostic variable of FeNO concentration of 14.0 ppb. A comparison of FeNO level and sex of the subjects showed there is no correlation between these parameters of patients. Conclusions. Currently, the FeNO measurement provides complementary d
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 253-258
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physical fatigue measured by functional MRI
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Ożog, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454820.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    functional MRI
    physical fatigue
    physiological condition
    temporary and chronic fatigue
    Opis:
    Introduction. Physical fatigue is a physiological condition that can be measured by functional Magnetic Resonance Imaging (fMRI). Aim. Therefore, this work aims to present the research results currently reported in the scientific literature between the years 2014 and 2018 in the field of chronic fatigue syndrome using the functional MRI method. Material and methods. Analysis of literature. Results. We reviewed here the differences between temporary and chronic fatigue.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 3; 239-244
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Granular cell tumor of the neurohypophysis – a case report
    Autorzy:
    Dziedzic, Rafał
    Leksa, Natalia
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454840.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    granulomatous tumor
    pituitary gland
    MRI
    Turkish saddle
    Opis:
    Introduction. The granulomatous tumor (GCT) is formed from the posterior pituitary (neurohypophysis) or its pedicle. The location of such a tumor in the region of the Turkish or supra saddle is a very rare matter. Aim. To present a case report. Description of the case. This article describes the case of a 39-year-old man admitted to the Department of Neurosurgery with a MR-diagnosed head tumor in the suprasellar area growing out of the pituitary funnel. The tumor appeared to be an epileptic fit. Conclusion. Herein we described a clinical case of granulomatous tumor. GCTs in the pituitary nerves are benign tumors, which makes treatment dependent on the individual case. After the operation, the H-P study showed a granulomatous tumor (GCT) of the posterior pituitary gland.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 378-380
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inflammatory bowel disease: clinical aspects
    Autorzy:
    Pasternak, Grzegorz
    Aebisher, David
    Filip, Rafał
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454879.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    inflammatory bowel diseases Leśniowski-Crohn’s disease ulcerative colitis
    mataloproteinases
    Opis:
    Introduction. Inflammatory bowel disease is a complex disease which arises as a result of an interaction between environmental and genetic factors leading to immunological responses and inflammation in the intestine. Aim. To review medical approaches used in inflammatory bowel disorders. Materials and methods. An analysis of literature regarding inflammatory bowel diseases, Leśniowski-Crohn’s disease, ulcerative colitis and mataloproteinases. Results. Current evidence suggests that patients with inflammatory bowel disease may have an elevated risk of endothelial dysfunction and coronary artery disease. Over the past two decades, great advances have been made in our understanding of the interplay between the inflammatory bowel disease. Conclusions. Inflammatory bowel diseases are increasing in Europe. The diagnosis is usually confirmed by biopsies on colonoscopy
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 341-345
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Treating kidney cancer – a review
    Autorzy:
    Przyczyna, Piotr
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454983.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    kidney cancer
    malignant tumors
    MRI
    Opis:
    Introduction. Kidney cancer in the structure of registered cases was in 6th place in men and 8th in women. Aim. Understanding the molecular biology of renal cell carcinoma has made it possible to produce new diagnostic methods. Material and methods. This review was performed according to a systematic literature search. Results. Minimally invasive techniques seem to have a bright future in kidney cancer. However, they still require many clinical trials before they enter the general clinical use. Conclusion. Photodynamic therapy, thanks to research conducted in kidney cancer, will find application in cancer of other organs.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 38-41
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnostyka obrazowa okiem neurologa
    Imaging diagnostics through the eyes of a neurologist
    Autorzy:
    Leksa, Natalia
    Truszkiewicz, Adrian
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/985943.pdf
    Data publikacji:
    2019
    Wydawca:
    Indygo Zahir Media
    Tematy:
    spektroskopia
    diagnostyka obrazowa
    KT
    MR
    USG
    PET
    SPECT
    angiografia
    spectroscopy
    diagnostic imaging
    CT
    angiography
    Opis:
    W diagnostyce chorób układu nerwowego dostępne jest szerokie spektrum metod diagnostycznych. Niektóre są wykonywane powszechnie, inne tylko w ośrodkach specjalistycznych. W opracowaniu poniżej omówiliśmy badania obrazowe stosowane w diagnostyce chorób neurologicznych. Szeroko omówiona diagnostyka w kontekście neurologicznym pozwala na uwypuklenie potrzeb, jakie istnieją w tym zakresie z punktu widzenia lekarza neurologa. Pokazano również wartości różnych badań dla różnych schorzeń neurologicznych. Praca ta nie może wyczerpać tematu, jakim jest diagnostyka obrazowa okiem neurologa, ze względu na rozległość tematyki. Założeniem jej jest dokonanie przeglądu dostępnych metod obrazowania i ukazanie ich wartości w leczeniu pacjentów.
    A wide spectrum of diagnostic methods are available in the diagnosis of nervous system diseases. Some are commonly performed, others only in specialist centers. In the study below, we discussed imaging tests used to diagnose neurological diseases. The broadly discussed diagnostics in the neurological context allow to highlight the needs that exist in this regard from the point of view of the neurologist. The values of various studies for various neurological diseases are also shown. This work cannot exhaust the topic of diagnostic imaging through the eyes of a neurologist due to the extent of the subject. Its assumption is to review the available imaging methods and show their value in treating patients.
    Źródło:
    Inżynier i Fizyk Medyczny; 2019, 8, 5; 363-370
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Trastuzumab Efficacy Quantified by Fluorine-19 Magnetic Resonance Imaging
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Czmil, Mrs Anna
    Mazur, Damian
    Powiązania:
    https://bibliotekanauki.pl/articles/895489.pdf
    Data publikacji:
    2020-06-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    trastuzumab
    magnetic resonance imaging
    breast cancer cells
    three-dimensional cell culture
    Trastuzumab conjugates
    Opis:
    The purpose of this study was to conjugate Trastuzumab with fluorine-bearing PAMAM dendrimer to compare activities in three-dimensional (3D) cultured breast cancer cells with parent Trastuzumab. An in vitro study was performed to determine cellular responses to fluorinated Trastuzumab conjugates by Magnetic Resonance Imaging (MRI). Breast cancer cells were cultured in 3D geometry. Proton (1H) MRI and Fluorine-19 (19F) MRI were used for visualization of cellular locations within a Hollow Fiber Bioreactor (HFBR) device and to monitor the cellular response to treatment. The results of this study confirm that cell growth is significantly decreased following treatment with Trastuzumab conjugates. The use of fluorinated Trastuzumab conjugates decreases breast cancer cell growth in 3D cultures and allows for tracking of drug delivery to cancer cells via 19F.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 495-503
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The potential of phythotherapy in otorhinolaryngology
    Autorzy:
    Domka, Wojciech
    Aebisher, David
    Bober, Zuzanna
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454662.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    phytotherapy
    medicinal plants
    otorhinolaryngology
    Opis:
    Introduction. The objective of this paper is to review the evidence of the use of herbs in phytotherapy. Aim. To discuss plant properties and applications in otorhinolaryngology. Materials and methods. We analysed literature and collected information of phythotherapy in otorhinolaryngology. Results. The databases were searched using various keywords such as phytotherapy, otorhinolaryngology, and herbs such as: echinacea, eucalyptus, garlic, ginkgo, ginseng, kava, pelargonium sidoides, rosemary, spirulina, St John’s wort, and thyme. Conclusions. Due to the beneficial impact of meicinal plants in medicine there is a growing interest in analytical identification and quantification for clinical medicine and forensic toxicology.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 359-365
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The usefulness of relaxation time using MRI measurements
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Truszkiewicz, Adrian
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454698.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    Magnetic Resonance Imaging
    T1 relaxation
    field strength 1.5 Tesla
    Opis:
    Introduction. Magnetic Resonance Imaging methods are now frequently used for the analysis of the diseased tissue. These methods are based on the fact that the spin-lattice, T1 , and the spin-spin, T2 , relaxation times are different in diseased tissue as compared to that of normal tissue. Aim. Here we present measurements of spin-lattice relaxation time T1 on a Magnetic Resonance Imaging scaner with field strength 1.5 Tesla. Material and methods. Measurements of T1 relaxation time and analysis of literature. Results. We provide procedure for measurements of T1 relaxation time with field strength 1.5 Tesla and present a discussion of current applications.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 3; 224-227
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Medicinal benefits from the use of Black pepper, Curcuma and Ginger
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożog, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454723.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    medicinal plants
    phythotherapy
    Black pepper
    Curcuma
    Ginger
    Opis:
    Introduction. Black pepper, Curcuma and Ginger are three of the most popular and most frequently used spices. Due to their beneficial medical and pharmacological properties, they are increasingly appreciated phytotheraputic plants. Most of their actions are attributed to their biochemical compositions. Aim. Our intention is to equip the reader with the information and knowledge necessary to understand the role of natural products in the drug discovery process and to enable the assessment of potential benefits and harms of plant-based medicines when advising patients who wish to use them. Material and methods. Analysis of literature. Results. In this paper, we reviewed the use of Black pepper, Curcuma and Ginger documented in the treatment of colds and flu,
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 133-145
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Glycosaminoglycan concentration in cancer tissue
    Autorzy:
    Bar, Piotr
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454799.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    fixed charge density glycosaminoglyca
    magnetic resonance imaging
    Opis:
    Introduction. Glycosaminoglycans (GAGs) play a widespread role in tissue modelling. GAG polymers may affect several receptor pathways in parallel. Aim. To present difference in concentration of GAG in healthy and cancer tissues. Material and methods. The literature search was performed nd reviewed using selected keywords. Results. We revieved the methods of detection various types of glycans measured by Magnetic Resonance Imaging. Conclusion. MRI methodology provides an efficient tool forstudy of cellular composition. The use T1 aof T2 measurements to study cancer tissue is a promising assay.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 175-178
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Radio Frequency MRI coils
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Bober, Zuzanna
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454860.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    field strength 1.5 Tesla
    magnetic resonance imaging
    radio frequency coil
    Opis:
    Introduction. Magnetic Resonance Imaging (MRI) coils technology is a powerful improvement for clinical diagnostics. This includes opportunities for mathematical and physical research into coil design. Aim. Here we present the method applied to MRI coil array designs. Material and methods. Analysis of literature and self-research. Results. The coils that emit the radiofrequency pulses are designed similarly. As much as possible, they deliver the same strength of radiofrequency to all voxels within their imaging volume. Surface coils on the other hand are usually not embedded in cylindrical surfaces relatively close to the surface of the body. Conclusion. The presented here results relates to the art of magnetic resonance imaging (MRI) and RF coils design. It finds particular application of RF coils in conjunction with bore type MRI scanners.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 24-27
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Infliximab in therapy of inflammatory bowels diseases
    Autorzy:
    Bar, Piotr
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454884.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    infliximab
    TNFα
    ulcerative colitis
    Opis:
    Introduction. Infliximab is a monoclonal antibody that acts against tumor necrosis factor TNF-α. The drug is used in the treatment of autoimmune diseases. Aim. This article reviewed the efficacy and safety of infliximab for the treatment in severe ulcerative colitis. This review included studies that evaluated the clinical use of infliximab. Material and methods. This meta-analysis was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Infliximab has been approved by the US Food and Drug Administration (FDA) as a medicine to treat Leśniowski and Crohn’s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. However, further trials are required to compare other parameters of efficacy such as the clinical response with infliximab. Conclusion. In patients suffering from Crohn’s disease or ulcerative colitis under infliximab maintenance therapy, sustained good trough levels are associated with: better response and remission rates, more mucosal healing and less loss of response.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 79-82
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Plants – a source of therapeutic material?
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454997.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    plants
    natural products
    drug
    therapeutic material
    Opis:
    Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs. Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation. Material and methods. Analysis of literature.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 34-36
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vascular surgery and an occurrence of stroke
    Autorzy:
    Leksa, Natalia
    Uryniak, Adam
    Aebisher, David
    Leksa, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2038333.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cerebral arteries
    diagnosis
    stroke
    Opis:
    Introduction. The brain responds to metabolic disorders with a limited array of symptoms and signs. The brain has enormous needs in terms of substrate and blood flow. Aim. This paper presents a case report reporting episode of stroke. Description of the case. The incidence of cerebral vascular episodes in the form of strokes, transient episodes of cerebral ischemia is reported. Conclusion. The chemical constituency of the brain are generally quite different from those of other tissues. Stroke is a clinical syndrome characterized by sudden focal or generalized brain dysfunction.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 233-235
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Contrast-enhanced Magnetic Resonance Imaging of lung cell cultures
    Autorzy:
    Bober, Zuzanna
    Pogoda, Katarzyna
    Aebisher, David
    Tabarkiewcz, Jacek
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/895529.pdf
    Data publikacji:
    2020-04-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    Lung cancer
    cell cultures
    magnetic resonance imaging
    contrast media
    Gadolinium
    Opis:
    Lung cancer is one of the most common types of cancer diagnosed, and the development of methods to image diseased lung tissue by MRI is of utmost importance. Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) was used to noninvasively evaluate spin-spin relaxation time, T1, of lung cell cultures infused with various clinical gadolinium-based contrast media for imaging. In this study we used a clinical 1.5 Tesla scanner and the contrast agents: Omniscan, MultiHance, Gadovist and ProHance. A significant five-fold reduction of T1 relaxation time was obtained.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 251-258
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Multiparametric MRI and other imaging methods suitable to stage prostate carcinoma
    Autorzy:
    Osuchowski, Michał
    Aebisher, David
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454672.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    Prostate cancer
    multiparametric MRI (mpMRI) biparametric MRI (bpMRI)
    staging
    Opis:
    Introduction. The role of multiparametric magnetic resonance imaging (mpMRI) in staging prostate carcinoma has been increasing over the last years. It’s high sensitivity is indispensable when diagnosing this disease. It is a very accurate imaging method that helps the physician choose the best treatment method for his patient. Aim. Assessment of mpMRI which uses both anatomic and functional imaging techniques as a method to diagnose prostatic lesions. Advantages and disadvantages of staging prostate carcinoma with the use of biparametric MRI (bpMRI). Methods. The literature search was performed. Results. MpMRI can be used in pre-operative staging of prostate cancer. The technique is accurate in diagnosing and assessment of prostate carcinoma with Gleason Score (GS) of 7 and above. It is also recommended when planning a second biopsy of the prostatic gland.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 331-333
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The advancement of imaging in diagnosis of prostate cancer
    Autorzy:
    Osuchowski, Michał
    Aebisher, David
    Gustalik, Joanna
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454680.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    MRI
    PET
    prostate carcinoma
    Opis:
    Introduction. Multiple imaging methods have been used to stage prostate carcinoma. Some of them are easily accessible, others very accurate. The advancements over many years have been taken under consideration and now every imaging method has a specific role in the diagnosis of this malignancy. Aim. There are over 1,100,000 cases of prostate carcinoma diagnosed every year around the world. Imaging examinations have to be introduced to accurately stage, and therefore properly treat this disease. This review concentrates on advantages and disadvantages of different imaging methods. Material and methods. The literature search was performed. Results. Imaging methods serve specific goals. TRUS is recommended for acquiring biopsy specimen due to high accessibilityand low cost of the examination. Conclusion. The best tool for staging prostate carcinoma and finding suspicious lesions when attempting second biopsy is mpMRI or bpMRI
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 67-70
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fundamentals of the use of Berberis as a medicinal plant
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454712.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    medicinal plants
    phythotherapy
    Berberis
    Opis:
    Introduction. The daily use of medicinal plants has increased in recent years. The study of drugs of natural origin as an academic discipline and its applications in healthcare has changed remarkably but still focus on the quality of products and the development of new medicines. Aim. This study covers all fundamental aspects of pharmacognosy as well as topics relating to the therapeutic use of plant drugs known as phythotherapy. The purpose of the study was to review the literature about the use of Berberis. Materials and method. We reviewed the literature regarding the use of Berberis published between 1933 and 2018. We found more than 500 articles studying the properties of Berberis for digestive disorders, antibacterial, antidiabetic, hypotensive effects, anti-inflammatory effects, cholesterol regulation, cardiovascular disease, hyperlipidemia, cerebral ischemia trauma, mental disease, Alzheimer disease and osteoporosis. Our review includes recent studies regarding chemical composition and medicinal outcomes of Berberis
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 41-46
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Functional MRI – how does it work?
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Przypek, Aneta
    Guz, Wiesław
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454947.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    deoxyhemoglobin
    oxyhemoglobin
    Magnetic Resonance Imaging functional Magnetic Resonance Imaging
    Opis:
    Magnetic Nuclear Resonance (MRI) is a non-invasive tissue imaging method. This technique is based on the influence of a strong magnetic field and electromagnetic wave of strictly defined frequency on the nucleus of elements with non-zero spin. The study describes one of the variants of functional MRI, (fMRI), which has become a key technique in brain imaging. This technique has excellent spatial and temporal resolution and involves a changing signal intensity depending on the degree of oxygenation of the blood. Blood oxygenation levels are known to vary in accordance with neural activity and these differences can be used to detect brain activity. This is due to increased demand for energy and oxygen in the area of increased neural activity. The basis of this imaging is the so-called Blood Oxygenation-Level Dependent (BLOD) effect. The aim of this paper is to present the scope of fMRI as a diagnostic method in neurology and in neurosurgery. This paper presents the principles of fMRI, methods of application, research result development, and suggests areas of possible medical applications. The limitations of fMRI as a clinical tool in medical applications will also be addressed. Studies presented in this paper are based on clinical fMRI experience and a literature review.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 120-126
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sarkoidoza w badaniu MR
    Sarcoidosis in MR examination
    Autorzy:
    Stanowski, Dariusz
    Leksa, Natalia
    Truszkiewicz, Adrian
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/985924.pdf
    Data publikacji:
    2019
    Wydawca:
    Indygo Zahir Media
    Tematy:
    sarkoidoza
    rezonans magnetyczny
    neurologia
    układ nerwowy
    sarcoidosis
    magnetic resonance imaging
    neurology
    nervous system
    Opis:
    Rezonans magnetyczny jest podstawowym narzędziem w arsenale badań, jakim dysponuje dzisiejsza neurologia. Badanie to w sposób całkowicie nieinwazyjny pozwala odpowiedzieć na szereg pytań związanych zarówno z morfologią, jak również przemianami, jakie zachodzą w OUN. Niniejsza praca prezentuje opis przypadku sarkoidozy jako choroby, dla której rezonans magnetyczny jest metodą z wyboru. Praca ta ma na celu ukazanie rezonansu jako wszechstronnej metody diagnostycznej w neurologii. Sarkoidoza – przewlekła choroba układu odpornościowego. W chwili obecnej jej etiologia nie jest dostatecznie wyjaśniona. Możliwość występowania w niemal wszystkich narządach ciała oraz konieczność różnicowania z innymi jednostkami chorobowymi czyni jednostkę tę trudną w diagnostyce. Niniejsza praca prezentuje sarkoidozę w diagnostyce rezonansu magnetycznego (MR). Opis przypadku ukazuje zarówno spojrzenie kliniczne, jak również trudności diagnostyczne.
    Magnetic resonance imaging is an essential tool in the research of today’s neurology. This study in a completely non-invasive way allows you to answer a number of questions related to both morphology as well as changes that occur in the CNS. This work presents a case report of sarcoidosis as a disease for which magnetic resonance imaging is the method of choice. This work aims to show resonance as a comprehensive diagnostic method in neurology. Sarcoidosis – a chronic disease of the immune system. At present, its etiology is not sufficiently explained. The possibility of occurring in almost all organs of the body and the need to differentiate with other disease entities makes this entity difficult to diagnose. This work presents sarcoidosis in magnetic resonance imaging (MR). The case report shows both clinical view and diagnostic difficulties.
    Źródło:
    Inżynier i Fizyk Medyczny; 2019, 8, 5; 379-382
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physician Survey of Practices on Diet, Physical Activity and Weight Control: Questionnaire on Adult Care – validation of the Polish language version of the questionnaire
    Autorzy:
    Hubert-Lutecka, Agnieszka
    Bartusik-Aebisher, Dorota
    Żal, Marcin
    Binkowska-Bury, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/454692.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diet
    physical activity
    weight control
    Opis:
    Introduction. According to the World Health Organization, non-infectious chronic diseases will become the leading cause of disability by 2020 and can be the most expensive health problem. Type 2 diabetes, hypertension, smoking, poor eating habits, insufficient physical activity and the resulting overweight and obesity are among the main modifiable factors of non-infectious chronic diseases. The results of epidemiological studies indicate that the prevalence of these factors in the Polish population is constantly growing, which is associated with the dissemination of unfavorable eating habits and sedentary lifestyle. Their combating and preventive and educational activities of patients in the scope of modifiable lifestyle behaviors related to lifestyle should be implemented primarily through primary care physicians. Aim. To validate the Polish language version of Physician Survey of Practices on Diet, Physical Activity and Weight Control: Questionnaire on Adult Care. Material and methods. A Polish version of the questionnaire “Physician Survey of Practices on Diet, Physical Activity and Weight Control: Questionnaire on Adult Care” was created. Validation was carried out on a group of 30 primary care physicians. Results. Very good results in terms of internal coherence of the questionnaire were obtained - the Alpha-Crombach coefficient was 0.82. The level of reproducibility was established with an ICC factor, which was 0.81. Conclusions. The tested Polish version of the questionnaire can be used to conduct research among primary care physicians in Poland
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 3; 177-183
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Military candidate health qualification and adjudication
    Autorzy:
    Żal, Marcin
    Wiech, Paweł
    Bartusik-Aebisher, Dorota
    Hejda, Grażyna
    Binkowska-Bury, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/454674.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    egal regulations
    civilians subject to military qualifications health status
    army
    Opis:
    ntroduction. This study reviews the link between personal health and military qualifications. It was found that there is evidence of a strong link between obesity levels across young individuals and military qualification adjudication. Aim. The purpose of the study was to review the literature about significance of the rules for adjudicating on the ability to perform active military service and analysis of the literature regarding the health condition of Polish citizens subject to perform obligatory military service. Materials and method. Analysis of foreign and Polish literature
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 146-150
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New fluorescent imaging technics in gastrology
    Autorzy:
    Sosna, Barbara
    Bartusik-Aebisher, Dorota
    Cieślar, Grzegorz
    Kawczyk-Krupka, Aleksandra
    Latos, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/2040160.pdf
    Data publikacji:
    2021-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diagnostics
    fluorescent imaging
    gastrology
    Opis:
    Introduction. There is a need to develop a new imaging technique in medicine. Gastroenterology is the branch of medicine focused on the digestive system and its disorders therefore for this branch is needed to detect all problems affecting the gastrointestinal tract. Aim. The aim of this article is to complete discuss the possibility of the new fluorescent imaging technics in gastrology to use innovative screening to identify individuals at an early stage. Material and methods. We discuss here imaging techniques such as include x-rays, computed tomography, scans, and magnetic resonance imaging in gastrology. Spectroscopy is the study of the formation and interpretation of spectra resulting from the interaction of all types of radiation on matter understood as a community of atoms and molecules. Various spectroscopic techniques are obtained by combining different types of radiation with different ways of its interaction with the test sample. They provide the opportunity to obtain detailed information about the tested substance – from its atomic composition, through its chemical structure, to its surface structure. Analysis of the literatue. The tissue fluorescence spectrum can be obtained by: (1) autofluorescence, or natural or primary fluorescence, i.e. by direct irradiation of the tissue with laser radiation (laser-induced fluorescence – LIF) and (2) photodynamic diagnosis (PDD), where spectrum analysis is preceded by systemic or local administration of the photosensitizer. Conclusion. The use of fluorescence imaging in colon cancer patient has potential to improve quality of treatment and diagnosis.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 3; 251-254
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New endoscopic treatment methods for PPI-resistant GERD
    Autorzy:
    Sosna, Barbara
    Bartusik-Aebisher, Dorota
    Cieślar, Grzegorz
    Kawczyk-Krupka, Aleksandra
    Latos, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/2040513.pdf
    Data publikacji:
    2021-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diagnostics
    endoscopic treatment
    gastrology
    Opis:
    Introduction. Gastroesophageal reflux disease (GERD) is a common disease with the highest prevalence in North America. Up to 40% of patients report persistent gastroesophageal reflux disease (GERD) symptoms despite proton pump inhibitor (PPI) therapy. Aim. The aim of this article is to complete discuss the GERD characterized by heartburn and/or regurgitation symptoms. Material and methods. We discuss here the evidence for medical therapy for PPI nonresponsive GERD. Analysis of the literature. GERD may present with a variety of other symptoms, including water brash, chest pain or discomfort, dysphagia, belching, epigastric pain, nausea, and bloating. In addition, patients may experience extraesophageal symptoms like cough, hoarseness, throat clearing, throat pain or burning, wheezing, and sleep disturbances. Conclusion. There has been an increase in GERD prevalence. GERD is one of the most common gastrointestinal disorders managed by gastroenterologists and primary care physicians.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 4; 322-325
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Magnetic Resonance Elastography – noninvasive method to assess liver disease
    Autorzy:
    Ożóg, Łukasz
    Aebisher, David
    Bober, Zuzanna
    Bartusik-Aebisher, Dorota
    Guz, Wiesław
    Cholewa, Marian
    Powiązania:
    https://bibliotekanauki.pl/articles/454714.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    fibrosis
    liver stiffness
    MRE
    magnetic resonance imaging
    Opis:
    Currently, liver disease is widespread and the awareness of these diseases is low. Early symptoms of liver disease do not necessarily indicate problems with this organ and patients are usually informed of their problems when the stage of the disease is already advanced. Invasive biopsies are the clinical diagnostic method most commonly used in the evaluation of liver disease. A biopsy is associated with a high risk of false results and additional complications. Finding new non-invasive imaging methods has led to the discovery of a new method called Magnetic Resonance Elastography (MRE). This technique allows one to evaluate the mechanical properties of tissues and to distinguish between pathological states. Testing using this technique can be performed on a conventional magnetic resonance system by using few additional components and properly prepared software. Studies have shown that there is a strong correlation between MRE-measured liver stiffness and the degree of fibrosis. MRE is also useful in characterizing liver tumors. Studies show that this technique is highly credible in both health volunteers and patients with liver fibrosis. MRE has tremendous diagnostic potential. The described technique is not currently widely used and has the 127-132potential to serve as a safe and accurate alternative in clinical diagnostics in the future.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 127-132
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Imaging studies of kidney cancer
    Autorzy:
    Przyczyna, Piotr
    Aebisher, David
    Gustalik, Joanna
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1597349.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    Kidney cancer
    MRI
    PET
    Opis:
    In 2017 in the USA about 5% in men and 3% in women newly diagnosed cases of malignant tumors were kidney and renal pelvis cancer. Aim. Kidney cancer in adults includes malignant tumors derived from kidney parenchyma and renal pelvis. The dominating types are kidney parenchyma, and mainly renal cell carcinomas Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Imaging studies play a very important role in kidney cancer. They allow one to assess the clinical stage, justify the extent of surgery and have an impact on the prognosis. Conclusion. The field for research involves the use of magnetic resonance and positron emission tomography in diagnosing kidney changes.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 334-337
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sciatic vessels – a case report
    Autorzy:
    Gałuszka, Łukasz
    Leksa, Natalia
    Leksa, Dawid
    Uryniak, Adam
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2040141.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    artery
    sciatic vessels
    surgical treatment
    Opis:
    Introduction. Sciatic vessels most often accompany the sciatic nerve. Sciatic vessels are very rare. Aim. In this paper we determine the procedure in sciatic vessels surgical treatment. Description of the case. We present the case of a 75-year-old patient with symptoms of acute right lower limb ischemia. The patient was discharged home in good condition, and remains in outpatient control to this day. Conclusion. The popliteal artery proved to be available, but much deeper than usual.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 4; 326-327
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The use of imaging tests to obtain optimal margins in breast surgery
    Autorzy:
    Ostańska, Elżbieta
    Bartusik-Aebisher, Dorota
    Gustalik, Joanna
    Aebisher, David
    Galiniak, Sabina
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1597322.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast conserving surgery
    ductal carcinoma in situ
    extensive itraductal component invasive breast cancer
    lobular carcinoma in situ
    Opis:
    Introduction. The proper negative margins (R0) breadth in the breast - conserving surgery for invasive breast cancer (IBC) and ductal carcinoma in situ (DCIS) is very important. The presence positive surgical margins (R1) is associated with the necessity of reoperation. It delays the adjuvant therapy and psychologically burdens the patient. The re-operation increases the costs of treatment. The introduction of mammography (MMG) increased detection of DCIS by 20%. With the increase in malignancy, cancer detection decreases in MMG, inversely in MRI groving. Effective preoperative and intraoperative diagnosis aims to reduce the number of R1 resections. Aim. The size of the tumor next to its biology, determines the clinical course of the tumor. The accurate analysis of imaging tests is important. Material and methods. This analysis was performed using a systematic literature search. Results. Adequate surgical margins in breast cancer surgery for breast cancer have been reviewed. It is important to know if the cancer is multifocal and what the extent of the tumor is. Conclusion. The adequacy of margins is important for adjusting the volume of excision. It is avoiding unnecessary resection of healthy breast tissue. It is essential for a good cosmetic result and the local recurrence rate. The combination of breast MRI with conventional breast imaging resulted in the lover rate of the R1 resectios and the lower rate of the re-operation.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 246-249
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Tabarkiewicz, Jacek
    Guz, Wiesław
    Tutka, Piotr
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454783.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    drug delivery systems
    drug forms
    magnetic resonance imaging pharmaceuticals
    Opis:
    Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 110-119
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    19F MRI As a tool for imaging drug delivery to tissue and individual cells
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Ożóg, Łukasz
    Tabarkiewicz, Jacek
    Tutka, Piotr
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454941.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    drug delivery
    drug tracking
    fluorine
    magnetic resonance imaging
    Opis:
    Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 99-109
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adrenomyeloneuropathy – a case report
    Autorzy:
    Leksa, Natalia
    Aebisher, David
    Galiniak, Sabina
    Uberman-Kluz, Dominika
    Bartosz, Serweryn
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454995.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    adrenoleukodystrophy
    fatty acids
    steroid therapy
    Opis:
    Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 274-276
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1 H Magnetic Resonance Imaging in vitro
    Autorzy:
    Pogoda, Katarzyna
    Pucka, Maria
    Tabarkiewicz, Jacek
    Bober, Zuzanna
    Aebisher, David
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454731.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cell cultures
    lung cancer
    lycopene
    kidney cancer
    magnetic resonance imaging relaxation times
    Opis:
    Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 5-9
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnostic and therapeutic difficulties of tick-borne encephalitis – a two case reports
    Autorzy:
    Przetacznik, Dominika
    Leksa, Natalia
    Aebisher, David
    Galiniak, Sabina
    Bartosz, Seweryn
    Leksa, Dawid
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2037691.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diagnostic
    tick borne encephalitis
    treatments
    Opis:
    Introduction. The paper presents epidemiology, routes of infection, forms of the disease, diagnostic and treatment methods, and prophylaxis of tick-borne encephalitis. Aim. In this paper, we present two descriptions of the cases of tick-borne encephalitis. Description of the cases. Case 1. A 60-year-old man with fever up to 39 degrees for 3 days, multi-site headache and other body aches, as well as an earstuck feeling. The day before hospitalization, there was a feeling of numbness on the right side of the face from eye level to the chin and speech distortion. Case 2. A 60-year-old patient with headaches and an increase in temperature to 39 degrees for 3 days, who, approximately, three weeks earlier was ticked by a tick in the lower parts of the back. Conclusion. It is also important for doctors to take a broader view and to make society aware of that Lyme disease is not associated only with Lyme disease. Further work is also needed towards effective treatments for Tick-borne encephalitis (TBE).
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 2; 135-140
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Generation of retractive spine circuits in the process of vitamin B12 deficiency
    Autorzy:
    Mucha, Patrycja
    Leksa, Natalia
    Aebisher, David
    Galiniak, Sabina
    Bartosz, Seweryn
    Leksa, Dawid
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2037833.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    ataxia
    B12 avitaminosis
    retinal spinal cord degeneratio
    Opis:
    Introduction. Subacute degeneration of the posterior and lateral spinal cord is a rare neurological complication of B12 avitaminosis. Aim. In this paper, we present the case of a 65-year-old man who, in the course of long-term vitamin B12 deficiency associated with atrophic gastritis, developed a severe set of neurological symptoms that are part of the retinal spinal cord degeneration with characteristic features in MR imaging of the cervical spine in the form of an inverted “V mark” ‘in axial images and typical localization in the spinal cord. Description of the case. After careful analysis of the syndrome and making an early diagnosis, parenteral vitamin B12 supplementation began, resulting in improved neurological status, laboratory parameters as well as regression of changes in magnetic resonance imaging. Conclusion Significant symptoms of this syndrome are paresthesia in the distal parts of the limbs, ataxia, spastic paresis.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 2; 131-134
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An iliac artery aneurysm
    Autorzy:
    Leksa, Natalia
    Leksa, Dawid
    Gałuszka, Łukasz
    Uryniak, Adam
    Aebisher, David
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2038415.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    arteriograph
    iliac artery aneurysms
    intravascular therapy
    Stent-Graft
    Opis:
    Introduction. Isolated common iliac artery aneurysms (CIAs) are rare. The rarer are rupture of the common iliac artery. We can treat them surgically: classic or endovascular. Open surgery has a main role in the management of aneurysms not suitable for repair by endovascular techniques. Aim. The aim of the study is to present the possibility of occurrence of such a disease at a young age, to indicate non-characteristic symptoms that may predict the above-mentioned disease entity at the level of a primary care physician or SOR. Review of medical publications from 2000-2019 regarding guidelines or methods of conduct in that cases. Description of the case. A patient 39 years old, admitted to the Department of Vascular Surgery, in an interview: about 15 years ago severely beaten, as a result of injuries total loss of hearing, memory and basic skills such as: speech, writing, reading, hospitalized over 6 months. Conclusion. Good rehabilitation and patient persistence restored cognitive skills. Advances in surgical has lowered the mortality and morbidity rates even in patients.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 242-244
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stroke masks – a case report
    Autorzy:
    Chmielewska, Beata
    Leksa, Natalia
    Aebisher, David
    Galiniak, Sabina
    Leksa, Dawid
    Bartosz, Seweryn
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2038416.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    brain metabolic disorders
    MRI
    stroke
    Opis:
    Introduction. Stroke is a common vascular disease encountered in the work of a practitioner. Despite this, his differentiation is difficult. This is due to a variety of diseases that can be a “mask” for stroke. These are neurological diseases other than vascular (brain tumors, epilepsy), head injuries and a number of metabolic disorders (fluctuations in glucose, electrolytes). Aim. This work aims to approximate the differentiation of this common disease entity. Case reports show both clinical view and diagnostic difficulties. Description of the cases. Case 1. The patient 59 years old treated for bipolar disorder, hypertension and alcohol abuse. Case 2. The patient 68 years old treated for type 2 diabetes, hypertension, ischemic heart disease, cholecystolithiasis – cholecystectomy. Conclusion. Stroke is a significant clinical and social problem both in Poland and in the world. Despite this, its diagnostics and especially differentiation is difficult. When analyzing the case of each patient with suspected sudden CNS vascular disease, all of them should be remembered. It should also be borne in mind that differential diagnosis cannot delay specific treatment for stroke
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 245-249
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Infliximab MRI relaxation time in solution
    Autorzy:
    Bober, Zuzanna
    Bar, Piotr
    Pasternak, Grzegorz
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454757.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    infliximab
    magnetic resonance imaging relaxation time
    Opis:
    Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1 ) relaxation time and discuss differences where compare to water. Results. The measurements ofspin-lattice (T1 ) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 22-25
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Epidemiology of breast cancer in Podkapackie voivodship
    Autorzy:
    Gustalik, Joanna
    Bartusik-Aebisher, Dorota
    Ostańska, Elżbieta
    Przyczyna, Piotr
    Osuchowski, Michał
    Aebisher, David
    Galiniak, Sabina
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454657.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast cancer
    statistics
    epidemiology
    podkarpackie voivodship
    Opis:
    Introduction. Breast cancer is the second most prevalent reason for cancer deaths after lung cancer. Incidence rates have increased worldwide. Aim. To present epidemiology of breast cancer in Podkapackie voivodship. Material and methods. This analysis was performed using a systematic literature search. Results. In the Podkarpackie voivodship up until 2014, the incidence rate of female breast cancer was rising and in 2015 it dropped by 68 cases. Even though the survival rate is increasing, it is still one of the leading causes of cancer deaths placing second after lung cancer. Conclusion. Mortality rate, unfortunately, rose gradually. This shows that even though there is a National Health Program aiming at breast cancer awareness and prevention, it is still not enough to reduce the number of breast cancer deaths.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 242-245
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical application of advanced neuroimaging techniques – Magnetic Resonance Spectroscopy
    Autorzy:
    Guz, Wiesław
    Bober, Zuzanna
    Ożóg, Łukasz
    Truszkiewicz, Adrian
    Przypek, Aneta
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Urbanik, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/454826.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    spectroscopy
    MR
    SVS
    CSI
    Opis:
    Continuous scientific research and the increasing saturation of the medical market in Poland implements the possibilities of using advanced MR techniques including MRS in everyday practice. This method, which has so far been used primarily for research purposes, can bring measurable benefits to patients not only in terms of clarifying diagnosis and narrowing differential diagnosis, but also monitoring the course of various diseases and their treatment. Here we present the basic principles of performing and interpreting spectroscopic spectra and possible clinical applications and development prospects of MRS. The literature reviewed both Polish and foreign articles both historically and in the past 10 years. The paper presents methodological issues related to the proper performance of magnetic resonance spectroscopy (MRS) and spectral composition and the role of major metabolites, as well as current clinical applications and directions of MRS development.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 133-140
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Applications of cytisine extraction and detection in biological materials for clinical medicine
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Courtney, Ryan
    Sobczak, Andrzej
    Bober, Zuzanna
    Podgórski, Rafał
    Kołodziejczyk, Patrycjusz
    Tutka, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/895314.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    smoking cessation
    chromatography
    Biomedicine
    cytisine extraction
    biopharmacy
    Opis:
    Tobacco use is a leading cause of preventable mortality worldwide. New cost-effective smoking cessation treatments are needed especially in some low-to-middle income countries where smoking rates are rising, and current pharmacotherapy treatments remain cost-prohibitive. Since the 1960’s, cytisine has been used as an effective nicotine substitution agent to aid in smoking cessation albeit limited to a selected few Eastern/Central Europe and Central Asian countries. Cytisine is a biologically active alkaloid of plant origin and is known to be a ligand of nicotinic acetylcholinergic receptors (nAChRs). For several decades, the properties of cytisine have been investigated and reported in the biomedical and pharmaceutical literature. Due to the beneficial impact of cytisine on smoking cessation and its costly multistep synthesis, there is a growing interest in extraction from natural sources as well as in analytical identification and quantification for clinical medicine and forensic toxicology. In this paper, we present several current analytical approaches to cytisine extraction and identification from biological samples of plant and human origin. The development of extraction techniques will allow for the widespread use of the drug in experimental and clinical pharmacology, toxicology and forensic medicine.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 797-804
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ASL (Arterial Spin Labeling) – historical and current perfusion MR methods
    Autorzy:
    Guz, Wiesław
    Bober, Zuzanna
    Ożóg, Łukasz
    Truszkiewicz, Adrian
    Przypek, Aneta
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Urbanik, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/454978.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    perfusion
    MR
    ASL
    Opis:
    Despite continuous scientific and technological advances in MR imaging, MR perfusion methods have not yet been widely deployed for routine clinical diagnostics. This is especially true for ASL (arterial spin labelling) methods used to evaluate cerebral perfusion. This method does not require a contrast agent, as new discoveries about gadolinium accumulation in the cerebellum and brain nucleus appear to be a valuable asset and provide the opportunity to be more widely deployed in clinical practice. The aim of this paper is to present the historical determinants of the development of MR perfusion techniques, the disadvantages and advantages and possible clinical applications and prospects of ASL development. Both historical articles published on MR in the 1990s and current research between 2006-2016 have been reviewed. The authors present in the work the MR perfusion method focusing on issues related to arterial spin labeling (ASL). Historically CASL (continuous ASL) and PCSL (pulsed ASL) techniques have been described and the pseudocontinuous ASL (pseudocontinuous ASL) 3D technique presents its technical and methodological considerations, advantages and disadvantages over previous methods. The methods of test protocol optimization and accompanying artifacts, as well as possible clinical applications and development perspectives, have been described.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 145-150
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine
    Autorzy:
    Leksa, Natalia
    Pękala, Anna
    Pardak, Piotr
    Dziedzic, Rafał
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Galiniak, Sabina
    Aeisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454702.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    13C NMR
    dynamic nuclear polarization hyperpolarized carbon
    Opis:
    Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine. Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 20-23
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of new biomarkers for the diagnosis and treatment of colon cancer
    Autorzy:
    Czarnecka-Czapczyńska, Magdalena
    Bartusik-Aebisher, Dorota
    Krupka-Olek, Magdalena
    Aebisher, David
    Cieślar, Grzegorz
    Latos, Wojciech
    Kawczyk-Krupka, Aleksandra
    Powiązania:
    https://bibliotekanauki.pl/articles/2040510.pdf
    Data publikacji:
    2021-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    colon cancer
    diagnosis
    treatment
    Opis:
    Introduction. Colorectal cancer may be benign or malignant. According to the World Health Organization and CDC, it is the second most common cancer worldwide, after lung cancer. The mortality of colorectal cancer has been dropping for more than 20 years due to the improvements in screening techniques and treatments. Aim. The aim of this article is to discuss the role of new biomarkers for the diagnosis and treatment of colon cancer. Material and methods. This article is a review done in regards to discuss the role of new biomarkers for the diagnosis and treatment of colon cancer. Analysis of the literature. A review is discussed the role of new biomarkers for the diagnosis and treatment of colon cancer using current literature. Conclusion. The screening tests based on diagnostic new biomarkers may cause faster detection of cancer and risk factors, and provide prognostic information in order to adjust individual therapy.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 4; 326-329
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Coagulation markers in diagnostic and monitoring of thromboembolic complication in COVID-19
    Autorzy:
    Czarnecka-Czapczyńska, Magdalena
    Bartusik-Aebisher, Dorota
    Krupka-Olek, Magdalena
    Aebisher, David
    Cieślar, Grzegorz
    Latos, Wojciech
    Kawczyk-Krupka, Aleksandra
    Powiązania:
    https://bibliotekanauki.pl/articles/2040166.pdf
    Data publikacji:
    2021-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    anticoagulation
    coagulation abnormalities
    COVID-19
    Opis:
    Introduction. Coronavirus disease 2019 (COVID-19) was first observed in China in Wuhan city, Hubei province in December, 2019, and specified as a pandemic by the World Health Organization (WHO). COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2). Aim. The aim of this article is to discuss epidemiology of thromboembolic complication in COVID-19. Material and methods. This article is a review done in regards to discuss clinical features of the anticoagulation treatment in COVID-19. Analysis of the literature. A review is discussed an anticoagulation treatment in 41 manuscripts. Conclusion. Most commonly coagulation abnormalities in patient with COVID-19 is mild thrombocytopenia. Apart from their typical role in thrombosis and hemostasis, platelets mediate key aspects of immune and inflammatory.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 3; 241-245
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytisine parameters measured in the 1.5 Tesla magnetic field
    Autorzy:
    Bober, Zuzanna
    Galiniak, Sabina
    Leksa, Dawid
    Dynarowicz, Klaudia
    Aebisher, David
    Ostańska, Elżbieta
    Czmil, Anna
    Bar, Piotr
    Bartusik-Aebisher, Dorota
    Tutka, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/454807.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cytisine
    desmoxan
    magnetic resonance imagin
    tabex
    Opis:
    Introduction. Cytisine, Cytisinum (C11H14N2O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla. Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules. Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg). Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substances.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 16-19
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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