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    Wyświetlanie 1-6 z 6
    Tytuł:
    Effect of repeated cold water swimming exercise on adaptive changes in body weight in older rats
    Autorzy:
    Bryczkowska, Iwona
    Baranowska-Bosiacka, Irena
    Lubkowska, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1055019.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
    Tematy:
    body weight
    cold-acclimation
    exercise training
    rats
    swimming exercise
    Opis:
    The aim of this study was verification whether an 8-week-long swimming exercise training would induce adaptive changes in body weight in rats and whether possible changes would depend on aquatic environment temperature and animal sex. The exercisetrained groups swam 4 minutes a day, five days a week during eight week of housing. Exercise was performed by swimming in glass tanks containing tap water maintained according to group at 5 ±2°C (cold group) and 36 ±2°C (thermal neutral group). Before and after each week of the experiment, rats were weighed. When comparing the nature of changes in the body weight of rats exposed to swimming exercise training in cold water, attention should be paid to their dependence on sex. There were statistically significant changes in the nature of changes in body weight between male rats and female rats of the cold group (5°C) as early as experimental week 2 until the end of the experiment (p < 0.001). Interestingly, the females exposed to swimming exercise training at 5°C were the only group in which an increase in body weight occurred during experimental week 8 in relation to baseline values.
    Źródło:
    Central European Journal of Sport Sciences and Medicine; 2017, 18, 2; 77-87
    2300-9705
    2353-2807
    Pojawia się w:
    Central European Journal of Sport Sciences and Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pro-inflammatory properties of cadmium
    Autorzy:
    Olszowski, Tomasz
    Baranowska-Bosiacka, Irena
    Gutowska, Izabela
    Chlubek, Dariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039631.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    inflammatory mediators and markers
    cadmium
    Opis:
    Cadmium is a toxic and carcinogenic heavy metal that nowadays constitutes a serious environmental health problem. The aim of this study is to review the effects of cadmium on selected inflammatory mediators and markers, such as NF-κB and AP-1 transcription factors, IL-6, TNF-α, IL-1β cytokines, IL-8 or MIP-2 chemokine, MPO, iNOS, MMPs and COX-2 enzymes, PGE2 (product of COX-2 enzyme), ICAM-1, VCAM-1 and PECAM-1 adhesion molecules, and CRP. The research strategy identified articles available in Medline, published between 1998 and 2012; we included both in vivo and in vitro studies carried out on humans and rodents. Most of the reviewed research findings suggest that cadmium in micromolar concentrations (especially in the 1-10 μM range) causes up-regulation of the mediators and markers of inflammation, and appears to have pro-inflammatory properties. However, it is worth mentioning that a contradictory or even opposite hypothesis exists, which suggests cadmium to be an anti-inflammatory factor. Further research including detailed histological analyses should solve this discrepancy. Nevertheless, it appears that the main reason for these contradictory findings is the experimental setup: different biological systems analyzed and different doses of cadmium applied.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 4; 475-482
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biochemical and medical importance of vanadium compounds
    Autorzy:
    Korbecki, Jan
    Baranowska-Bosiacka, Irena
    Gutowska, Izabela
    Chlubek, Dariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039732.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    inflammation
    cancer
    vanadium
    diabetes
    insulin-mimetic action
    pollution
    Opis:
    Vanadium belongs to the group of transition metals and is present in the air and soil contaminants in large urban agglomerations due to combustion of fossil fuels. It forms numerous inorganic compounds (vanadyl sulfate, sodium metavanadate, sodium orthovanadate, vanadium pentoxide) as well as complexes with organic compounds (BMOV, BEOV, METVAN). Depending on the research model, vanadium compounds exhibit antitumor or carcinogenic properties. Vanadium compounds generate ROS as a result of Fenton's reaction or of the reaction with atmospheric oxygen. They inactivate the Cdc25B2 phosphatase and lead to degradation of Cdc25C, which induces G2/M phase arrest. In cells, vanadium compounds activate numerous signaling pathways and transcription factors, including PI3K-PKB/Akt-mTOR, NF-κB, MEK1/2-ERK, that cause cell survival or increased expression and release of VEGF. Vanadium compounds inhibit p53-dependent apoptosis and promote entry into the S phase of cells containing functional p53 protein. In addition, vanadium compounds, in particular organic derivatives, have insulin-mimetic and antidiabetic properties. Vanadium compounds lower blood glucose levels in animals and in clinical trials. They also inhibit the activity of protein tyrosine phosphatase 1B. By activating the PI3K-PKB/Akt pathway, vanadium compaunds increase the cellular uptake of glucose by the GLUT4 transporter. The PKB/Akt pathway is also used to inactivate glycogen synthase kinase-3. The impact of vanadium compounds on inflammatory reactions has not been fully studied. Vanadium pentoxide causes expression of COX-2 and the release of proinflammatory cytokines in a human lung fibroblast model. Other vanadium compounds activate NF-κB in macrophages by activating IKKβ.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 2; 195-200
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cyclooxygenase pathways
    Autorzy:
    Korbecki, Jan
    Baranowska-Bosiacka, Irena
    Gutowska, Izabela
    Chlubek, Dariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039189.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cyclooxygenase
    prostaglandin
    15-deoxy-Δ12,14-prostaglandin J2
    receptor desensitization
    Opis:
    This review compiles the current knowledge on the effects of prostanoids - arachidonic acid metabolites - on their own synthesis, activity and degradation. Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between a thromboxane A2 and prostaglandin I2 receptors. The questions of desensitization and internalization of receptors are discussed. The stages of the inflammatory response and tumor progression are analyzed against the background of the disruption of the synthesis of prostanoids. Special attention is given to the significance of 15-deoxy-Δ12,14-prostaglandin J2 in the regulation of the synthesis of prostanoids and its role as an anti-inflammatory agent. Ultimately, therapeutic approaches as used in various treatments are discussed in the light of the available knowledge.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 4; 639-649
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of new non-cross resistant antitumour agents on the energy state of human erythrocytes
    Autorzy:
    Nowak, Robert
    Baranowska-Bosiacka, Irena
    Stefańska, Barbara
    Machaliński, Bogusław
    Hłyńczak, Alina
    Tarasiuk, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1041354.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    non-cross resistant antitumour benzoperimidines and anthrapyridones
    ATP-dependent efflux
    erythrocytes
    multidrug resistance
    energy state
    Opis:
    Multidrug resistance (MDR) of tumour cells is related to the overexpression of ATP-dependent pumps responsible for the active efflux of antitumour agents out of resistant cells. Benzoperimidine and anthrapyridone compounds exhibit comparable cytotoxic activity against sensitive and MDR tumour cells. They diffuse extremely rapidly across the plasma membrane and render the ATP-dependent efflux inefficient. Such uptake could disturb an energy metabolism of normal cells possessing an elevated level of ATP-dependent proteins, especially erythrocytes having a high level of the MRP1, MRP4 and MRP5 proteins. In this study the effect of five antitumour agents: benzoperimidine (BP1), anthrapyridones (CO1, CO7) and reference drugs used in the clinic: doxorubicin (DOX) and pirarubicin (PIRA), on the energetic state in human erythrocytes has been examined. These compounds have various types of structure and kinetics of cellular uptake (slow - DOX, CO7, moderate - PIRA, fast - BP1, CO1) resulting in their different ability to saturate ATP-dependent transporters. The energetic state of erythrocytes was examined by determination of purine nucleotide contents (ATP, ADP, AMP), NAD+ and values of adenylate energy charge (AEC) using an HPLC method. It was found that the level of nucleotides as well as the AEC value of erythrocytes were not changed during 24 h of incubation with these agents independently of their structure and ability to saturate ATP-dependent pumps. This is a very promising result in view of their potential use in the clinic as antitumour drugs against multidrug resistant cancers.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 4; 953-957
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of the Yerba mate (Ilex paraguariensis) brewing method on the content of selected elements and antioxidant potential of infusions
    Autorzy:
    Janda, Katarzyna
    Jakubczyk, Karolina
    Łukomska, Agnieszka
    Baranowska-Bosiacka, Irena
    Rębacz-Maron, Ewa
    Dec, Karolina
    Kochman, Joanna
    Gutowska, Izabela
    Powiązania:
    https://bibliotekanauki.pl/articles/779918.pdf
    Data publikacji:
    2020
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    Yerba
    antioxidant activity
    infusions
    minerals
    Opis:
    Yerba mate is a source of biologically active substances. The aim was to determine whether the place of origin of Yerba and the brewing method have any influence on the levels of Ca, Mg and Fe and antioxidant activity of infusions. Samples were steeped in cold water (25o C) and hot water (three consecutive infusions with 85o C water). Infusions had a high antioxidant activity and high Mg level. The levels of elements and the antioxidant activity were influenced by the brewing method. There were no significant differences in the examined parameters depending on the country of origin. The results on the levels of elements and the antioxidant activity indicate that the most efficient brewing method was infusion in hot water. The highest levels of elements were found in first infusions, with the highest antioxidant activity in the third infusions.
    Źródło:
    Polish Journal of Chemical Technology; 2020, 22, 1; 54-60
    1509-8117
    1899-4741
    Pojawia się w:
    Polish Journal of Chemical Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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