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Tytuł:
The effect of alpha-chymotrypsin inhibitor from Ascaris lumbricoides suum on chick embryos
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/838045.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
pathological change
alpha-chymotrypsin
Ascaris lumbricoides suum
mortality
host organism
Leghorn breed
inhibitor
chicken
embryo
Opis:
It has been found that alpha-chymotrypsin inhibitor isolated from Ascaris lumbricoides suum acts embryotoxically on the Leghorn chicken embryo. An increase in embryo mortality with increasing dose of the inhibitor has been observed after its administration into the yolk sac on day 4, 8 or 13 of incubation. There is a linear interrelationship between the logarithm of the dose of alpha-chymotrypsin inhibitor and the mortality of chickens. The LD50 values foralpha-chymotrypsin inhibitor increased for injections performed at later stages of embryo development. A significant decrease of mean mass of chicks injected with alpha-chymotrypsin inhibitor in comparison with control groups was observed. There was a more frequent occurrence of developmental abnormalities and pathological changes in groups of hatched chicks which received the Ascaris inhibitor.
Źródło:
Annals of Parasitology; 1998, 44, 1
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of alpha-chymotrypsin inhibitor from Ascaris lumbricoides suum on chick embryos
Wplyw inhibitora alfa-chymotrypsyny z Ascaris lumbricoides suum na zarodki kurze
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/838348.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
glista ludzka
zarodki kurze
alfa-chymotrypsyna
chymotrypsyna
inhibitory
Ascaris lumbricoides
parazytologia
pasozyty
Opis:
It has been found that alpha-chymotrypsin inhibitor isolated from Ascaris lumbricoides suum acts embryotoxically on the Leghorn chicken embryo. An increase in embryo mortality with increasing dose of the inhibitor has been observed after its administration into the yolk sac on day 4, 8 or 13 of incubation. There is a linear interrelationship between the logarithm of the dose of alpha-chymotrypsin inhibitor and the mortality of chickens. The LD50 values for alpha-chymotrypsin inhibitor increased for injections performed at later stages of embryo development. A significant decrease of mean mass of chicks injected with alpha-chymotrypsin inhibitor in comparison with control groups was observed. There was a more frequent occurrence of developmental abnormalities and pathological changes in groups of hatched chicks which received the Ascaris inhibitor.
Źródło:
Annals of Parasitology; 1998, 44, 1; 63-71
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Disturbances of mouse pregnancy after injection of Ascaris homogenate during early organogenesis
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/838767.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
pregnancy
teratogenicity
tegumental homogenate
mouse
mice
Ascaris
Ascaris suum
organogenesis
homogenate
embryotoxicity
Opis:
Administration of the Ascaris tegumental homogenate (0.6-1.2 g of Ascaris proteins/kg/day) at a early stage of organogenesis (5-9 days of pregnancy) had a harmful effect upon the developing mouse fetuses. It has been found that injection of the homogenate did not delay or prevent implantation, but causes a high rate of intrauterine deaths. The Ascaris homogenate significantly decreased the number of live fetuses per litter, increased the frequency of litter resorption, produced a delay in bone formation and induced pathological changes of fetal organs and tissues. The congenital malformations were noted in fetuses after injection of higher doses of Ascaris homogenate (exencephaly, craniomeningocele and intemal hydrocephalus). No malformations were noted in control groups and after injection of minimum dose of the homogenate. The symptoms that occurred after administration of the tegumental homogenate to pregnant mice included: decreased body weight gain (p<0.001) as compared to controls, vaginal hemorrhage, intrauterine resorption of litter and mortality. These signs suggest that the Ascaris homogenate causes matemal toxicity.
Źródło:
Annals of Parasitology; 2000, 46, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary evaluation of maternotoxic effect of Ascaris extract in mice
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/839667.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
pregnancy
disturbance
mouse
mice
mortality
extract
Ascaris suum
maternal effect
toxic effect
embryotoxicity
evaluation
Opis:
Administration intraperitoneally of the Ascaris suum extract - ASE-(0.6-1.4 g of Ascaris proteins/kg/day) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. lt has been found that injections of higher doses of ASE to pregnant mice caused the symptoms manifesting maternal toxicity (decreased body weight gain /p < 0.001/ as compared to control, intrauterine resorption of litter, vaginal hemorrhages, female mortality and altered behaviour). There is a linear interrelationship between the logarithm of the dose of ASE and mortality of pregnant mice. The DL₅₀ value of Ascaris proteins for pregnant mice was 1.02 g/kg/day (confidence interval 0.97-1.07 g/kg/day). ASE exerted embryotoxic effects: significantly decreased the number of surviving fetuses per litter and the mean body weight of fetuses, increased the number of fetal resorptions.
Źródło:
Annals of Parasitology; 2003, 49, 2
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Parasitic infection and disturbances of fertility in humans
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/836198.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
reproduction
human disease
disturbance
man
fertility
reproductive system
parasitic infection
Opis:
According to literature of the problem, the disturbances of reproductiveness of human in various parasitic infections are discussed. The mechanisms disturbing the proper functioning of the hosts's reproductive system are not sufficiently understood. They may remain in association not only with a direct or indirect effect of the parasite on the host's endocrinal glands and sexual organs, but also with the host's overall reaction to stress or toxic influences. Parasite's activity may lead to abortion or a significant decrease in fetal body weight. Embryo or fetus may be also damaged in an intrauterine infection.
Źródło:
Annals of Parasitology; 1998, 44, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of alpha-chymotrypsin inhibitor from Ascaris lumbricoides suum on chick embryos
Wpływ inhibitora alfa-chymotrypsyny z Ascaris lumbricoides suum na zarodki kurze
Autorzy:
Blaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2148849.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
glista ludzka
zarodki kurze
alfa-chymotrypsyna
chymotrypsyna
inhibitory
Ascaris lumbricoides
parazytologia
pasozyty
Opis:
It has been found that alpha-chymotrypsin inhibitor isolated from Ascaris lumbricoides suum acts embryotoxically on the Leghorn chicken embryo. An increase in embryo mortality with increasing dose of the inhibitor has been observed after its administration into the yolk sac on day 4, 8 or 13 of incubation. There is a linear interrelationship between the logarithm of the dose of alpha-chymotrypsin inhibitor and the mortality of chickens. The LD50 values for alpha-chymotrypsin inhibitor increased for injections performed at later stages of embryo development. A significant decrease of mean mass of chicks injected with alpha-chymotrypsin inhibitor in comparison with control groups was observed. There was a more frequent occurrence of developmental abnormalities and pathological changes in groups of hatched chicks which received the Ascaris inhibitor.
Źródło:
Wiadomości Parazytologiczne; 1998, 44, 1; 63-71
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Parasitic infection and disturbances of fertility in humans
INWAZJE PASOŻYTNICZE A ZABURZENIA PŁODNOŚCI CZŁOWIEKA
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2148889.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
reproduction
human disease
disturbance
man
fertility
reproductive system
parasitic infection
Opis:
According to literature of the problem, the disturbances of reproductiveness of human in various parasitic infections are discussed. The mechanisms disturbing the proper functioning of the hosts's reproductive system are not sufficiently understood. They may remain in association not only with a direct or indirect effect of the parasite on the host's endocrinal glands and sexual organs, but also with the host's overall reaction to stress or toxic influences. Parasite's activity may lead to abortion or a significant decrease in fetal body weight. Embryo or fetus may be also damaged in an intrauterine infection.
Źródło:
Wiadomości Parazytologiczne; 1998, 44, 4; 639-645
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Ascaris trypsin inhibitor on fetal development of mice
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2146383.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mouse
mice
trypsin inhibitor
fetal development
Ascaris suum
Opis:
In this study, maternal toxicity and developmental effects of exposure to Ascaris trypsin inhibitor were evaluated in mice. Pregnant BALB/c females were injected intraperitoneally by Ascaris inhibitor /AIT/ at 200, 300, and 400 mg/kg body weight/day, on days 12 to 15 of gestation (stage of fetal development). At day 19 of pregnancy, uterine contents were inspected for implantation sites, early resorptions (moles), living fetuses and dead fetuses. The living fetuses were weighed and examined for external, internal and skeletal abnormalities. The results showed that AIT induced maternal toxicity, evidenced by maternal deaths, abortions, bleeding from uterus and reduced body weight gain as compared to control (p <0.01). There were no differences between the control group and the rest of all groups investigated for total implantation sites and early resorptions. Fetotoxicity was observed as shown by the decrease in the number of living fetuses and mean fetal weight, a high rate of intrauterine fetal deaths, delayed skeletal ossification, occurrence of pathological changes of fetal organs and tissues. Only one type of congenital malformations (hydronephrosis) was noted in fetuses after injection of higher doses of AIT.
Źródło:
Wiadomości Parazytologiczne; 2005, 51, 2; 133-138
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Ascaris chymotripsin inhibitor on fetal development of mice
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2147464.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mouse
mice
fetal development
Ascaris suum
chymotrypsin inhibitor
Opis:
BALB/c mice were given daily doses of 40-80 mg of Ascaris chymotrypsin inhibitor /AChl/ per kg body weight from 12" until 15" day of gestation (stage of fetal development). It has been found that injection of AChI disturbed the course of pregnancy (bleeding from uterus, abortions, decreased body weight gain as compared to control /p < 0.05/). AChI exhibited embryotoxic effects (a high rate of intrauterine deaths, decreased number of living fetuses and mean fetal weight, delayed skeletal ossification, induced pathological changes of fetal organs and tissues). Congenital malformation (hydronephrosis) was noted in fetuses after injection of higher doses of the chymotrypsin inhibitor from Ascaris.
Źródło:
Wiadomości Parazytologiczne; 2004, 50, 3; 513-518
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2147678.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Ascaris suum
teratogen
proteolysis inhibitor
developmental abnormality
inhibitor
chicken embryo
injection
Opis:
It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
Źródło:
Wiadomości Parazytologiczne; 2002, 48, 1; 55-64
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
XXXIV Dzien Kliniczny Parazytologii Lekarskiej - Wybrane aspekty terapii chorob pasozytniczych i grzybic
Autorzy:
Blaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/839682.pdf
Data publikacji:
1997
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
choroby pasozytnicze
parazytologia lekarska
konferencje
leczenie
Lodz konferencja
grzybice
Źródło:
Annals of Parasitology; 1997, 43, 1; 125-129
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/840466.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Ascaris suum
teratogen
proteolysis inhibitor
developmental abnormality
inhibitor
chicken embryo
injection
Opis:
It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
Źródło:
Annals of Parasitology; 2002, 48, 1
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary evaluation of maternotoxic effect of Ascaris extract in mice
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2147625.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
pregnancy
disturbance
mouse
mice
mortality
extract
Ascaris suum
maternal effect
toxic effect
embryotoxicity
evaluation
Opis:
Administration intraperitoneally of the Ascaris suum extract - ASE-(0.6-1.4 g of Ascaris proteins/kg/day) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. lt has been found that injections of higher doses of ASE to pregnant mice caused the symptoms manifesting maternal toxicity (decreased body weight gain /p < 0.001/ as compared to control, intrauterine resorption of litter, vaginal hemorrhages, female mortality and altered behaviour). There is a linear interrelationship between the logarithm of the dose of ASE and mortality of pregnant mice. The DL₅₀ value of Ascaris proteins for pregnant mice was 1.02 g/kg/day (confidence interval 0.97-1.07 g/kg/day). ASE exerted embryotoxic effects: significantly decreased the number of surviving fetuses per litter and the mean body weight of fetuses, increased the number of fetal resorptions.
Źródło:
Wiadomości Parazytologiczne; 2003, 49, 2; 187-194
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Disturbances of mouse pregnancy after injection of Ascaris homogenate during early organogenesis
ZABURZENIA PRZEBIEGU CIĄŻY U MYSZY PO INIEKCJI HOMOGENATU Z ASCARIS W CZASIE WCZESNEJ ORGANOGENEZY
Autorzy:
Blaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2148586.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
tegumental homogenate
mouse
mice
Ascaris
Ascaris suum
organogenesis
homogenate
embryotoxicity
pregnancy
teratogenicity
Opis:
Administration of the Ascaris tegumental homogenate (0.6-1.2 g of Ascaris proteins/kg/day) at a early stage of organogenesis (5-9 days of pregnancy) had a harmful effect upon the developing mouse fetuses. It has been found that injection of the homogenate did not delay or prevent implantation, but causes a high rate of intrauterine deaths. The Ascaris homogenate significantly decreased the number of live fetuses per litter, increased the frequency of litter resorption, produced a delay in bone formation and induced pathological changes of fetal organs and tissues. The congenital malformations were noted in fetuses after injection of higher doses of Ascaris homogenate (exencephaly, craniomeningocele and intemal hydrocephalus). No malformations were noted in control groups and after injection of minimum dose of the homogenate. The symptoms that occurred after administration of the tegumental homogenate to pregnant mice included: decreased body weight gain (p<0.001) as compared to controls, vaginal hemorrhage, intrauterine resorption of litter and mortality. These signs suggest that the Ascaris homogenate causes matemal toxicity.
Źródło:
Wiadomości Parazytologiczne; 2000, 46, 3; 369-378
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
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