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    Wyświetlanie 1-7 z 7
    Tytuł:
    Flow cytometric assessment of activation of peripheral blood platelets in dogs with normal platelet count and asymptomatic thrombocytopenia
    Autorzy:
    Zmigrodzka, M.
    Guzera, M.
    Winnicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/31870.pdf
    Data publikacji:
    2016
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Platelets play a crucial role in hemostasis. Their activation has not yet been evaluated in healthy dogs with a normal and low platelet count. The aim of this study was to determine the influence of activators on platelet activation in dogs with a normal platelet count and asymptomatic thrombocytopenia. 72 clinically healthy dogs were enrolled. Patients were allocated into three groups. Group 1 consisted of 30 dogs with a normal platelet count, group 2 included 22 dogs with a platelet count between 100 and 200×109/l and group 3 consisted of 20 dogs with a platelet count lower than 100×109/l. Platelet rich-plasma (PRP) was obtained from peripheral blood samples using tripotassium ethylenediaminetetraacetic acid (K3-EDTA) as anticoagulant. Next, platelets were stimulated using phorbol-12-myristate-13-acetate or thrombin, stabilized using procaine or left unstimulated. The expression of CD51 and CD41/CD61 was evaluated. Co-expression of CD41/CD61 and Annexin V served as a marker of platelet activation. The expression of CD41/CD61 and CD51 did not differ between the 3 groups. Thrombin-stimulated platelets had a significantly higher activity in dogs with a normal platelet count than in dogs with asymptomatic thrombocytopenia. Procaine inhibited platelet activity in all groups. In conclusion, activation of platelets of healthy dogs in vitro varied depending on the platelet count and platelet activator.
    Źródło:
    Polish Journal of Veterinary Sciences; 2016, 19, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of reticulated platelets in dogs with breed-related thrombocytopenia
    Autorzy:
    Zmigrodzka, M.
    Guzera, M.
    Winnicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/32313.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The aim of this study was to evaluate the percentage of reticulated platelets in healthy dogs with breed-related thrombocytopenia. Seventy two dogs, clinically healthy, were enrolled in the study. Blood was collected from the patients and anticoagulated with tripotassium ethylenediaminetetraacetic acid (K3-EDTA) and sodium citrate. Platelet count was obtained by an impedance haematology analyser and platelet morphology was evaluated by examination of blood smears. Patients were allocated into two groups. Group 1 consisted of 30 dogs with normal platelet count, whereas group 2 was composed of 42 dogs with thrombocytopenia. Thrombocytopenia was present in both K3-EDTA and citrate blood samples. Patients with thrombocytopenia were divided into two subgroups: the first subgroup included dogs with platelet count in K3-EDTA anticoagulated blood from 100 to 200 x10⁹/L, patients in the second subgroup had a platelet count of less than 100 x10⁹/L. The percentage of young reticulated platelets (RPs) labelled with thiazole orange, and the percentage of platelets coated with platelet surface-associated IgG, were determined in platelet-rich plasma (PRP) by a flow cytometer. The mean percentage of RPs in K3-EDTA and citrate PRP was significantly higher in dogs with thrombocytopenia than in dogs with normal platelet count. The mean percentage of RPs was significantly higher in citrate PRP than in K3-EDTA PRP in all groups. The results suggest that idiopathic, asymptomatic thrombocytopenia is not caused by platelet surface-associated IgG. Dogs with breed-related thrombocytopenia have a competent bone marrow.
    Źródło:
    Polish Journal of Veterinary Sciences; 2014, 17, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of the influence of ADTA-K3 and sodium citrate on haematology analysis in healthy dogs
    Autorzy:
    Zmigrodzka, M.
    Winnicka, A.
    Guzera, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/32272.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The study was carried out on 30 clinically healthy dogs of various breeds. Haemoglobin concentration, haematocrit, platelet count and platelet haematocrit were significantly lower in citrate blood than in tripotassium ethylenediaminetetraacetic acid (EDTA-K3) blood. The study confirmed the limited usage of sodium citrate in haematology analysis, unless canine EDTA-dependent thrombocytopenia is suspected.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of experimental administration of low zearalenone doses on the expression of Th1 and Th2 cytokines and on selected subpopulations of lymphocytes in intestinal lymph nodes
    Autorzy:
    Obramski, K.
    Wojtacha, P.
    Podlasz, P.
    Zmigrodzka, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/31393.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The aim of this study was to characterize the immune response taking place in ileocecal lymph nodes (ICLN) in control (n=15) and zearalenone (ZEN)-treated (n=15) pigs. The experiment was carried out over 42 days; a dose of 0.1 mg kg⁻¹ feed day⁻¹ of ZEN was administered to the animals. The dose used in the experiment was at a level where no adverse effects are observed (NOAEL) in the ovaries, uterus and vagina. ICLN samples for analysis were collected on the 14th, 28th and 42nd day of the experiment. The analysis of cytokine concentration in the tissues showed that pigs treated with ZEN had an increased level of cytokines produced by helper Th1 lymphocytes (IL-2, IL-12 and IFN- γ) on the 28th day of the experiment. The level of cytokines produced by helper Th2 lymphocytes (IL-4 and IL-10) was characterized by a statistically non-significant upward trend, as compared with the control group. Flow cytometry showed a linear decrease in the percentage of CD21+ B, CD2+ T and CD4+CD8- T cells and an increase in the percentage of CD8+CD4- and TCRγδ + T cells in pigs treated with ZEN. Both ZEN and α-ZEL (α-zearalenone) concentrations increased over time in the liver, but only ZEN concentration increased in ICLN. The results obtained demonstrate that a NOAEL concentration of ZEN shifts the immune response in pig ICLN towards Th1/Th17, probably with a simultaneous activation of M1 macrophages. Moreover, we observed an increase in humoral cytokine secretion; this can be explained by a negative feedback loop and a phenotypic switch of macrophages from M1 to M2, as well as a switch of immune response from Th1 to Th2 type. ZEN can therefore influence the process of cytokine secretion and the percentage of lymphocytes in ileocecal lymph nodes.
    Źródło:
    Polish Journal of Veterinary Sciences; 2015, 18, 3
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Występowanie kwasów halogenooctowych (HAA) podczas uzdatniania wody w Wodociągu Centralnym w Warszawie
    Formation of haloacetic acids during water treatment in the Central Waterworks of Warsaw
    Autorzy:
    Dojlido, J.
    Dmitruk, U.
    Żmigrodzka, M.
    Zaleska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/236504.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Zrzeszenie Inżynierów i Techników Sanitarnych
    Tematy:
    kwasy halogenooctowe (HAA)
    uzdatnianie wody
    dezynfekcja
    haloacetic acids (HAAs)
    water treatment
    disinfection
    Opis:
    Przebadano tworzenie się kwasów halogenooctowych (HAA) w procesie uzdatniania wody w Wodociągu Centralnym w Warszawie. Badania przeprowadzono w 2002 r. Woda była pobierana z Wisły za pomocą ujęć zatokowych i infiltracyjnych. Woda uzdatniona w różnych ciągach technologicznych była następnie dezynfekowana mieszaniną chloru gazowego i dwutlenku chloru. Stwierdzono zależność powstawania HAA od stężenia organicznych prekursorów obecnych w wodzie. Wraz ze wzrostem zawartości prekursorów (barwa, utlenialność, OWO, absorbancja w UV) stwierdzono wzrost stężenia powstających HAA. Zaobserwowano korelację między ilością tworzących się HAA i temperaturą wody. W porze zimowej stężenia kwasów halogenooctowych były niższe niż w porze letniej. Stwierdzono także, że wystąpiła korelacja między rodzajem dezynfektanta i stężeniem HAA. Najmniej kwasów powstawało podczas dezynfekcji wody tylko dwutlenkiem chloru. Stężenia HAA w wodzie uzdatnionej wahały się od 11 do 50 mg/m3 i były poniżej wartości zalecanej przez wytyczne WHO.
    The study was carried out with riverine water samples in 2002. The water entering the plant is drown from the Vistula by bank intake and infiltration, treated via different technological trains and disinfected with gaseous chlorine and/or chlorine dioxide. The formation of haloacetic acids (HAAs) was found to depend on the concentration of the organic precursors present in the water. When their content (expressed in terms of coloured matter concentration, COD, TOC, and UV absorbance) increased, so did HAAs concentration. There was a correlation between the amounts of the HAAs formed and water temperature; they were lower in the winter season than in the summer season. The type of the disinfectant used was also found to affect the concentration of HAAs, which was lower with chlorine dioxide. HAA concentrations in treated water ranged from 11 to 50 mg/m3 and were below the permissible value recommended by WHO guidelines.
    Źródło:
    Ochrona Środowiska; 2004, R. 26, nr 1, 1; 9-12
    1230-6169
    Pojawia się w:
    Ochrona Środowiska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of T-2 toxin on percentages of CD4plus, CD8plus, CD4plusCD8plus and CD21plus lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches
    Autorzy:
    Obremski, K.
    Podlasz, P.
    Zmigrodzka, M.
    Winnicka, A.
    Wozny, M.
    Brzuzan, P.
    Jakimiuk, E.
    Wojtacha, P.
    Gajecka, M.
    Zielonka, L.
    Gajecki, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/30985.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The immune system is one of the main toxicity targets of the T-2 toxin. In view of scant research data demonstrating the effect of T-2 on cellular and humoral responses in gut-associated lymphoid tissue (GALT), this study set out to investigate the effects of chronic exposure to low doses of the T-2 toxin (200 μg T-2 toxin kg⁻¹ feed) on percentages of CD4⁺ and CD8⁺ T lymphocytes, CD4⁺/CD8⁺ double-positive T lymphocytes, CD21⁺ B cells, and IL-2, IFN-γ, IL-4 and IL-10 mRNA expression levels in porcine ileal Peyer’s patches. The investigated material comprised ileum sections sampled from piglets (aged 8-10 weeks, body weight of 15-18 kg) on days 14, 28 and 42 of the experiment. After 42 days of exposure to T-2, a significant drop in the quantity of the IL-10 product was observed (R=0.94; S.E. 0.49-0.79; p<0.001). A gradual decrease in the amount of IL-4 and IFN-γ cytokine transcripts was found throughout the experiment, but the reported trend was not significant. On experimental days 14 and 42, a significant increase in the percentage of CD8⁺ T lymphocytes was observed in comparison with the control (p=0.04 and p=0.05, respectively), whereas on day 28, a significant decrease in the percentage of the above subpopulation was noted (p=0.00). The percentage of CD21⁺ B cells in the experimental group decreased steadily in comparison with the control, and the observed drop was significant on days 28 and 42 (p=0.06 and p=0.00, respectively). On days 14 and 28, the percentages of CD4⁺ and CD8⁺ T lymphocytes were lower in the experimental animals than in the control group, and the drop reported on day 28 was statistically significant (p=0.03).
    Źródło:
    Polish Journal of Veterinary Sciences; 2013, 16, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Polar [3+2] cycloaddition between N-methyl azomethine ylide and trans-3,3,3-trichloro-1-nitroprop-1-ene
    Autorzy:
    Żmigrodzka, Magdalena
    Sadowski, Mikołaj
    Kras, Jowita
    Dresler, Ewa
    Demchuk, Oleg M.
    Kula, Karolina
    Powiązania:
    https://bibliotekanauki.pl/articles/35118622.pdf
    Data publikacji:
    2022
    Wydawca:
    Radomskie Towarzystwo Naukowe
    Tematy:
    [3+2] cycloaddition
    nitroalkenes
    ylides
    [3+2] cykloaddycja
    nitroalkeny
    ylidy
    Opis:
    Pyrrolidines are important heterocyclic organic compounds which show biological effects. Many of them are successfully used in medicine. These compounds can also be applied in industry, for example as dyes or agrochemical substances. Therefore, the study of pyrrolidines chemistry is important for modern science. In this paper the pyrrolidines synthesis in [3+2] cycloaddition between Nmethyl azomethine ylide and trans-3,3,3-trichloro-1-nitroprop-1-ene was studied. The reaction was carried out experimentally and based on computational research. The obtained results show the reaction may be of a polar nature, and proceed under mild conditions leading to (3SR,4RS)-1-methyl-3-nitro-4-(trichloromethyl)pyrrolidine as a single reaction product. Probably, a similar protocol can be applied for analogous reactions involving other 2-substituted nitroethene analogues.
    Źródło:
    Scientiae Radices; 2022, 1, 1; 26-35
    2956-4808
    Pojawia się w:
    Scientiae Radices
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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