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Wyświetlanie 1-6 z 6
Tytuł:
Robustness of closed-loop glucose control systems
Autorzy:
Wyciślok, Artur
Śmieja, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/29432415.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
artificial pancreas
closed-loop control
insulin pump
type 1 diabetes
Opis:
The main purpose of this work is to provide an extensive, simulation-based comparison of robustness of PID and MPC algorithms in control of blood glucose levels in patients with type 1 diabetes and thus answer the question of their safety. Cohort testing, with 1000 simulated, randomized patients allowed to analyze specific control quality indicators, such as number of hypoglycemic events, and length of hypo- and hyperglycemia periods. Results show that both algorithms provide a reasonable safety level, taking into account natural changes of patients’ physiological parameters. At the same time, we point out drawbacks of each solution, as well as general problems arising in close-loop control of blood glucose level.
Źródło:
Archives of Control Sciences; 2023, 33, 3; 681--705
1230-2384
Pojawia się w:
Archives of Control Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sensitivity Analysis Aimed at Finding Potential Molecular Drug Targets
Analiza wra»liwo±ci ukierunkowana na poszukiwanie molekularnych celów dla leków
Autorzy:
Smieja, Jaroslaw
Kardyńska, Małgorzata
Pudlo, Marta
Powiązania:
https://bibliotekanauki.pl/articles/953271.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
sensitivity analysis
signaling pathways
molecular drug
targets
molekularne cele leków
analiza wrażliwości
szlaki sygnałowe
Opis:
Sensitivity analysis has become one of the standard tools in analysis of models of intracellular processes. Various methods have been proposed, developed for either local or global sensitivity of systems under investigation. In this work, we propose a method that may be used to find potential molecular drug targets, taking into account heterogeneity of population of cells with respect to their responses to a particular drug agent.
Źródło:
Mathematica Applicanda; 2019, 47, 2
1730-2668
2299-4009
Pojawia się w:
Mathematica Applicanda
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prediction of lung cancer patients’ response to combined chemo-radiotherapy using a personalized hybrid model
Predykcja odpowiedzi na kombinowaną terapię dla niedrobnokomórkowego raka płuc przy użyciu modelu hybrydowego
Autorzy:
Wołkowicz, Sebastian
Fujarewicz, Krzysztof
Kurpas, Monika
Łakomiec, Krzysztof
Śmieja, Jarosław
Suwiński, Rafal
Świerniak, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/953274.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
ersonalised medicine
lung cancer
therapy response pre-diction
terapia skojarzona
rak płuc
analiza przeżycia
przewidywanie odpowiedzi na terapię
Opis:
The paper presents a novel approach to prediction of the combined therapy outcome for non-small lung cancer patients. A hybrid model is proposed, consisting of two parts. The first one is a mathematical model of tumor response to therapy, whose parameters are estimated by a neural network based regressor, constituting the second component of the hybrid model. Estimation is based on data from mass spectrometry of patient blood plasma samples. Comparison of clinical and simulation-based survival curves is used to evaluate the quality of the model.
Źródło:
Mathematica Applicanda; 2019, 47, 2
1730-2668
2299-4009
Pojawia się w:
Mathematica Applicanda
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of energy consumption of a hybrid vehicle in real-world conditions
Autorzy:
Mamala, Jarosław
Graba, Mariusz
Bieniek, Andrzej
Prażnowski, Krzysztof
Augustynowicz, Andrzej
Śmieja, Michał
Powiązania:
https://bibliotekanauki.pl/articles/2038048.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
energy consumption
hybrid vehicle
road tests
energy share analysis
Opis:
The paper presents an analysis of energy consumption in a Plug-in Hybrid Electric Vehicle (PHEV) used in actual road conditions. Therefore, the paper features a comparison of the consumption of energy obtained from fuel and from energy taken from the vehicle’s batteries for each travel with a total distance of 5000 km. The instantaneous energy consumption per travelling kilometre in actual operating conditions for a combustion engine mode are within the range of 233 to 1170 Wh/km and for an electric motor mode are within the range of 135 to 420 Wh/km. The average values amount to 894 Wh/km for the combustion engine and 208 Wh/km for the electric motor. The experimental data was used to develop curves for the total energy consumption per 100km of road section travelled divided into particular engine types (combustion/electric), demonstrating a close correlation to actual operating conditions. These values were referred to the tested passenger vehicle’s approval data in a WLTP test, with the average values of 303 Wh/km and CO2 emission of 23 g/km.
Źródło:
Eksploatacja i Niezawodność; 2021, 23, 4; 636-645
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of biogas to supply the high compression ratio engine
Autorzy:
Bieniek, Andrzej
Mamala, Jarosław
Graba, Mariusz
Prażnowski, Krzysztof
Śmieja, Michał
Wereszczyński, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/134102.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Naukowe Silników Spalinowych
Tematy:
biogas
high compression ratio engine
emission
low power cogeneration system
biogaz
silnik o zwiększonym stopniu sprężania
emisja
układ kogeneracyjny małej mocy
Opis:
The study concerns the use of biogas as a fuel for supplying a modified self-ignition engine. As a result of the modifications made, the compression ratio was reduced and the engine was equipped with an ignition system and an electronically activated engine throttle. The changes have made it possible to burn biogas in a high compression ratio engine. The paper presents the results of research conducted on a low power cogeneration system with engine that drives an electrical machine cooperating with a 380/400 V network. The analysis includes, among other things, the possibility of producing electricity using biogas. The paper presents the influence of regulatory parameters such as the volume and composition of the supplied gas mixture and the degree of throttle opening on the obtained engine operation indicators and the driven electric machine. The tests were carried out in relation to the obtained ecological indicators depending on the concentration in the exhaust of such substances as: HC, CO, NOx.
Źródło:
Combustion Engines; 2019, 58, 4; 40-46
2300-9896
2658-1442
Pojawia się w:
Combustion Engines
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of energy efficiency and dynamics during car acceleration
Autorzy:
Graba, Mariusz
Bieniek, Andrzej
Prażnowski, Krzysztof
Hennek, Krystian
Mamala, Jarosław
Burdzik, Rafał
Śmieja, Michał
Powiązania:
https://bibliotekanauki.pl/articles/24200840.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
acceleration
fuel consumption
energy consumption
vehicle dynamics
acceleration dynamic index
Opis:
In this work, the authors focused on analyzing the energy efficiency and dynamics during car acceleration, featuring investigation of acceleration dynamics under various acceleration intensities. The tests were performed in the speed range between 45 km/h and 120 km/h, at a constant gear ratio. This enabled obtaining variable dynamic parameters of the acceleration process, ranging from about 0.1 to 1.4 m/s2, and recording variation in fuel consumption from 6.28 to 27.03 dm3/100km. The study focused on determining the relation between fuel consumption, energy efficiency and vehicle acceleration depending on the available drivetrain power. The relation between fuel consumption and vehicle acceleration was described by using the dynamic index. The proposed dynamic index takes into account the energy (from burned fuel) and vehicle acceleration intensity to obtain an objective metric for characterizing the acceleration process. The aforementioned index takes the form of the passenger car movement energy quality index and can be related to widely known physical properties, thus ensuring its universality. The index expresses the energy expenditure within the time needed to accelerate a vehicle weighing 1kg by a 1m distance. As opposed to other criteria that are applied to the assessment of passenger cars dynamics, the index shows a high determination coefficient R2 in excess of 0.99, and can be used as a universal metric to test other vehicle types.
Źródło:
Eksploatacja i Niezawodność; 2023, 25, 1; art. no. 17
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-6 z 6

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