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Tytuł:
Organizational roles and the work and organizational engagement
Autorzy:
Borkowska, Anna
Czerw, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2128454.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
job satisfaction
organization
work engagement
organizational commitment
Opis:
Purpose – The article aims to attempt to define the work and organization engagement of the employees of one of the exclusive hotel spa in Poland. The present paper proposes that organizational roles taken by employees differentiate symptoms of their engagement. The research aims to test the hypothesis and to show the differences at the level of concepts and behaviors. Design/methodology/approach – The following study is an attempt to define the work and organizational engagement of employees of one of the exclusive SPA (sanus per aquam) hotels in Poland. The study was conducted using qualitative methods in the form of individual interviews and a group interview. The study described is part of a bigger project implemented in a Hotel. One department within the hotel, the kitchen of the main restaurant, was chosen for analysis. As such, opinions of two managers of various ranks (the Chef and the Deputy Manager of the Hotel) and seven persons from the aforementioned department are presented in this paper. Findings – Data analysis allowed us to conclude that organizational roles performed by employees may, in an influential way, shape the level and mental representation of the work and organizational engagement. Our results show that the higher position an employee has in the organizational hierarchy, the better is his/her understanding and the bigger is level of engagement both in work and in the organisation. What’s more, higher organizational role is conducive to mixing these two perspectives, and the lower role makes them clearly separated.
Źródło:
Polish Psychological Bulletin; 2017, 2; 188-197
0079-2993
Pojawia się w:
Polish Psychological Bulletin
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kobiety i mężczyźni na stanowiskach menedżerskich – wyolbrzymione, czy niedoszacowane różnice?
Women and Men in Managerial Positions: Exaggerated or Underestimated Differences?
Autorzy:
Babiak, Jolanta
Bajcar, Beata
Borkowska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/598927.pdf
Data publikacji:
2017-02-15
Wydawca:
Instytut Pracy i Spraw Socjalnych
Tematy:
menedżerowie
kobiety
mężczyźni
style kierowania
osobowość
inteligencja emocjonalna
Managers
women
men
leadership styles
personality
emotional intelligence
Opis:
W literaturze na temat zarządzania menedżerowie kobiety nierzadko oceniane są jako mniej skuteczne i mniej kompetentne. Ponadto uważa się, że są mniej stabilne, bardziej emocjonalne i skoncentrowane na osobach. W niniejszym artykule podjęto próbę zweryfikowania powyższych przekonań poprzez diagnozę empiryczną wybranych charakterystyk psychologicznych i stosowanych stylów kierowania wśród 333 polskich menedżerów obu płci. W badaniach wykazano, że kobiety kierują zadaniowo, dbają o relacje międzyludzkie i charakteryzują się wyższą inteligencją emocjonalną. Zaprezentowane tu wyniki badań wskazują, że kobiety posiadają odpowiednie kompetencje do skutecznego realizowania roli kierowniczej.
It is not rare for management literature to assess the performance of women in management as being less effective and competent. Furthermore, they are deemed less stable, more emotional, and more focused on people. The article strives to verify this conviction through an empirical diagnosis of selected psychological traits and management styles among 333 Polish managers of both sexes. Research indicates that women are more task oriented, are concerned with inter–human relations, and are characterized as having greater emotional intelligence. The presented research results demonstrate that women do have competencies that are appropriate for performing managerial roles successfully.
Źródło:
Zarządzanie Zasobami Ludzkimi; 2017, 1(114); 45-56
1641-0874
Pojawia się w:
Zarządzanie Zasobami Ludzkimi
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Postępowanie w „trybie wyborczym” na przykładzie apelacji białostockiej (2011–2017)
Lawsuits in „election mode” on the example of the Białystok Appeal (2011–2017)
Autorzy:
Borkowska-Minko, Anna
Powiązania:
https://bibliotekanauki.pl/articles/585394.pdf
Data publikacji:
2019
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
Kodeks wyborczy
postępowanie w „trybie wyborczym”
Election Code
lawsuit in “election mode”
Opis:
Artykuł dotyczy postępowań w „trybie wyborczym” na podstawie artykułu 111 Kodeksu wyborczego. Autorka artykułu przeprowadziła badania ilościowe w sądach okręgowych na terenie całej Polski oraz badania jakościowe w sądach okręgowych apelacji białostockiej. Kwerenda akt sądowych dotyczyła lat 2011–2017. Znakomita większość postępowań prowadzonych w sądach w „trybie wyborczym”, dotyczyła wyborów samorządowych, rzadziej wyborów parlamentarnych, jeszcze rzadziej pozostałych rodzajów wyborów (prezydenckich, do Parlamentu Europejskiego). Badania odpowiadają na pytania: kto jest wnioskodawcą, kto uczestnikiem procesu, jakie żądania wysuwane są we wnioskach, jakie decyzje zapadają w sądach? Postępowania w „trybie wyborczym” odbywają się w specjalnym trybie 24-godzinnym, z przeprowadzonych badań wynika, że dużej części nie udaje się ich zakończyć w terminach narzuconych przez Kodeks wyborczy.
The article discusses the matter of lawsuits in “election mode”, based on the article 111 Election Code. Author of the article did complete research in courts in Poland and qualitative research in the courts in the area Białystok Appeal. The court files concerned the years 2011– 2017. The vast majority of cases conducted in courts in the “election mode” concerned local elections, less frequent parliamentary elections, rarely other types of elections (presidential election, elections to the European Parliament). The research answers the questions: who is the applicant, who participates in the lawsuits, what requests are being made in lawsuits in “election mode”, what decisions are taken in the courts? The lawsuits in “election mode” are held in a special 24-hours mode, the research shows that a large part of cases fail to complete within the time limits imposed by the Election Code.
Źródło:
Studia Wyborcze; 2019, 27; 19-44
1898-0082
Pojawia się w:
Studia Wyborcze
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apologia roli kobiety w Kościele w świetle wybranych wypowiedzi Prymasa Tysiąclecia
APOLOGIA FOR THE ROLE OF WOMAN IN VIEW OF SELECTED ADDRESSES OF THE PRIMATE OF THE MILLENNIUM
Autorzy:
Borkowska-Kniołek, Anna
Powiązania:
https://bibliotekanauki.pl/articles/558668.pdf
Data publikacji:
2008
Wydawca:
Gdańskie Seminarium Duchowne
Opis:
WSTĘP. 1. KSIĘGA RODZAJU „WIELKĄ KARTĄ RÓWNOŚCI SPOŁECZNEJ”. 2. KOBIETA W TRADYCJI JUDAISTYCZNEJ. 3. BÓG KARMIONY PRZEZ KOBIETĘ. 4. CHRYSTUS I KOBIETY. 5. WIELKA SOBOTA DNIEM KOBIET KATOLICKICH. 6. COAPOSTOLAE. 7. MULIEREM FORTEM QUIS INVENIET? ZAKOŃCZENIE.
Today it is a quite often held view that the Roman Catholic Church depreciates a woman’s worth by impeding her way to numerous domains of contemporary life and religious life in particular. The most common reproach is saying that the Catholic Church has created a privileged place in its hierarchy for men, while women are marginalized. Cardinal Stefan Wyszyński, the Primate of Poland, contended against those erroneous opinions. In his addresses he often related to The Book of Genesis, the ultimate source for Christian study of human dignity. In the Primate’s conviction it is a grand charter of social equality. The two stories of Creation show that a man as well as a woman are made in the image and likeness of God. It gives an incontestable evidence of the dignity of both of them. Both man and woman are equal in their nature and in the tasks they were given but are different in the matter of their predispositions to those tasks and the ways in which they execute them. This is why Christ had to come to the world and rehabilitate woman. A woman became mother of God – such a great elevation often forgotten. What is more, it is a woman first who encountered the Resurrected Christ. It was a reward for steadfast faith of Gospel women. Faith that led them beneath the cross and even farther. A woman was present in many sensitive situations the Church had to deal with, to exemplify: Saint Catherine of Siena made the papacy returned from Avignon to Rome or Dubrawka. Therefore, we can now say that the Christ, and following him the whole Church, contributed to the social advancement of woman. And if there happens to come forth a say as if a woman were discriminated in the Church, it usually concerns the exclusion of women from the priesthood. However, let us ask a question: is it really a discrimination or just the execution of the will of the Christ, who took into consideration predispositions of men and women to perform particular ministries in the Church. Women can not be priests by reason of other duties towards all baptized members of the Church. Since the Sixties we observe a revival of the question of woman’s role in the Church. Regulations change and woman’s dignity is frequently discussed.
Źródło:
Studia Gdańskie; 2008, 22; 27-41
0137-4338
Pojawia się w:
Studia Gdańskie
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
AS-30D hepatoma as a model to study on insulin resistance in vitro
Autorzy:
Wierzbicka-Bregier, Katarzyna
Brutkowski, Wojciech
Borkowska, Anna
Milewski, Krzysztof
Zabłocki, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1039458.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
AS-30D hepatoma
insulin resistance
palmitate
rosiglitazone
Opis:
Studies on insulin resistance of liver cells are often performed with the use of various hepatoma cell lines. Such an approach allows investigating selected biochemical pathways at the cellular level. However, possible modifications of metabolic processes due to the neoplastic nature of such cells must be considered. Expanding the diversity of hepatoma cell lines used in metabolic studies could deliver new data for comparison with those obtained for other cell lines and should reduce the risk of misleading conclusions. In this study rat hepatoma AS-30D cells were tested as a potential model for studies on palmitate-induced insulin resistance. It was found that insulin-induced Akt kinase phosphorylation was substantially reduced in cells incubated with palmitate at a concentration as low as 75 µM. This effect was not accompanied by excessive reactive oxygen species (ROS) generation or increased Jun N-terminal kinase (JNK) phosphorylation. Moreover, preincubation of AS-30D cells with rosiglitazone, an antidiabetic agonist of peroxisome proliferator-activated receptor gamma (PPARγ), efficiently prevented the palmitate-induced insulin resistance. We conclude that AS-30D hepatoma cells may be used as a model sensitive to insulin and vulnerable to palmitate-induced insulin resistance.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 635-640
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fecal lactoferrin, a marker of intestinal inflammation in children with inflammatory bowel disease
Autorzy:
Borkowska, Anna
Liberek, Anna
Łuczak, Grażyna
Jankowska, Agnieszka
Plata-Nazar, Katarzyna
Korzon, Maria
Kamińska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1039002.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
fecal lactoferrin
inflammatory bowel disease
children
Opis:
The aim of this study was to analyze the usefulness of fecal lactoferrin in the diagnosis and monitoring of inflammatory bowel disease (IBD) in children. The study included 52 children with IBD (24 with Crohn's disease and 28 with ulcerative colitis) aged between 0.92 and 18 years, and 41 IBD-free controls of similar age. Fecal concentration of lactoferrin was determined with a quantitative immunoenzymatic test. Fecal concentration of lactoferrin in children with IBD was significantly higher than in the controls. The cut-off value of fecal lactoferrin concentration optimally distinguishing between the children with IBD and the controls was identified as 13 μg/g. The sensitivity and specificity of this cut-off value equaled 80.7% and 92.7%, respectively, and its positive and negative prognostic values were 96.8% and 63.3%, respectively. Patients diagnosed with moderate Crohn's disease had significantly higher fecal concentrations of lactoferrin than children with the mild or inactive disease. Similarly, children with moderate ulcerative colitis showed significantly higher fecal concentrations of lactoferrin than individuals with the mild condition. No significant relationship was found between the fecal concentration of lactoferrin and the severity of endoscopic lesions. Patients with IBD and a positive result of fecal occult blood test were characterized by significantly higher concentrations of lactoferrin than the individuals with IBD and a negative result of this test. In conclusion, fecal concentration of lactoferrin seems to be a useful parameter for diagnosis and monitoring of IBD in children.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 541-545
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pourazowe uszkodzenie tętnic domózgowych ze szczególnym uwzględnieniem tętnic kręgowych: charakterystyka procesu diagnostyczno-terapeutycznego
Traumatic damage of cervical arteries with a particular consideration of vertebral arteries: characteristics of diagnostic therapeutic process
Autorzy:
Rogoziewicz, Marcin
Borkowska-Konieczna, Anna
Kozubski, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1053612.pdf
Data publikacji:
2013
Wydawca:
Medical Communications
Tematy:
rozwarstwienie tętnic domózgowych
uraz szyi
ultrasonografia
skrzeplina
udar mózgu
cervical and vertebral dissection
neck injury
ultrasonography
thrombus
stroke
Opis:
Vertebral artery dissection is a disease that occurs rarely, but binding, however, with serious consequences. It is estimated that this is one of the most common causes of ischemic stroke in people under 45 years of age. The diagnosis of vertebral artery damage is easier when the patient shows signs of the occurrence of neck injury (e.g. cut injuries). However, the dissection of the vessel may also be a result of the so-called blunt trauma to the mechanism of “whip” for example, during an accident or during application of the abdominal pressure. Initially there is a rupture of the arterial intima, followed by the detachment and the formation of thrombus. This leads to the formation of thrombus or narrowing the lumen closure resulting in a clinical cerebral ischemia and neurological symptoms. Thrombus formation in the so-called misrepresent the artery can also be a source of embolic material. In case of suspicion of vertebral artery dissection are important: monitoring the neurological status of the patient and careful diagnosis of vascular. The aim of this study was to present the current state of knowledge about the causes of damage to the vertebral arteries, characteristic of the symptoms, diagnostic options and treatments and negotiations. It is believed that early diagnosis of arterial dissection and application of treatment increases the chance of survival and the patient avoid permanent neurological complications.
Rozwarstwienie tętnic kręgowych jest chorobą występującą rzadko, niemniej wiążącą się z poważnymi konsekwencjami. Szacuje się, że jest to jedna z najczęstszych przyczyn udaru niedokrwiennego mózgu u osób przed 45. rokiem życia. Rozpoznanie uszkodzenia tętnic kręgowych jest łatwiejsze, gdy u chorego widoczne są ślady po doznanym urazie szyi (np. rana cięta). Rozwarstwienie naczynia może być również wynikiem tzw. urazów tępych w mechanizmie „bicza”, powstałych np. podczas kolizji drogowej lub w czasie działania tłoczni brzusznej. Początkowo dochodzi do pęknięcia błony wewnętrznej tętnicy, a następnie jej odwarstwienia i tworzenia skrzepliny – zwężającej lub zamykającej światło naczynia, czego następstwami są niedokrwienie mózgu i kliniczne objawy neurologiczne. Tworzenie skrzepliny w tzw. fałszywym świetle tętnicy może być także źródłem materiału zatorowego. W przypadku podejrzenia rozwarstwienia tętnicy kręgowej ważne są monitorowanie stanu neurologicznego pacjenta i wnikliwa diagnostyka naczyniowa. Celem pracy było przedstawienie aktualnego stanu wiedzy dotyczącej przyczyn uszkodzenia tętnic kręgowych, charakterystycznych dla jednostki objawów, możliwości diagnostycznych i sposobów leczenia oraz rokowań. Uważa się, że wczesne zdiagnozowanie rozwarstwienia tętnicy i zastosowanie leczenia zwiększa szansę na przeżycie, a chory unika trwałych powikłań neurologicznych.
Źródło:
Aktualności Neurologiczne; 2013, 13, 4; 279-286
1641-9227
2451-0696
Pojawia się w:
Aktualności Neurologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coexistence of type 1 diabetes mellitus and spinal muscular atrophy in an 8-year-old girl: a case report
Autorzy:
Borkowska, Anna
Jankowska, Agnieszka
Szlagatys-Sidorkiewicz, Agnieszka
Sztangierska, Beata
Liberek, Anna
Plata-Nazar, Katarzyna
Kamińska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1039156.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Spinal muscular atrophy
diabetes mellitus
children
Opis:
The spinal muscular atrophy is a rare autosomal recessive genetic disease characterized by the progressive loss of muscular strength. In its natural course the disease leads to death. Diabetes mellitus type 1 is an autoimmune metabolic disorder characterized by the disturbed insulin synthesis. This is a case report of an 8-year-old girl suffering from Werdnig Hoffman disease in whom DM1 was diagnosed. The unspecific clinical manifestation and diagnostic difficulties are presented in this paper. To the authors' knowledge, this is the first publication concerning the co-existence of these two medical conditions.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 167-168
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Time-dependent effect of leptin on renal Na+,K+-ATPase activity
Autorzy:
Marciniak, Andrzej
Jamroz-Wiśniewska, Anna
Borkowska, Ewelina
Bełtowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1041321.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mitogen-activated protein kinases
leptin
obesity
arterial hypertension
hydrogen peroxide
Na+,K+-ATPase
Opis:
Leptin, secreted by adipose tissue, is involved in the pathogenesis of arterial hypertension, however, the mechanisms through which leptin increases blood pressure are incompletely elucidated. We investigated the effect of leptin, administered for different time periods, on renal Na+,K+-ATPase activity in the rat. Leptin was infused under anesthesia into the abdominal aorta proximally to the renal arteries for 0.5-3 h. Leptin administered at doses of 1 and 10 µg/min per kg for 30 min decreased the Na+,K+-ATPase activity in the renal medulla. This effect disappeared when the hormone was infused for ≥1 h. Leptin infused for 3 h increased the Na+,K+-ATPase activity in the renal cortex and medulla. The stimulatory effect was abolished by a specific inhibitor of Janus kinases (JAKs), tyrphostin AG490, as well as by an NAD(P)H oxidase inhibitor, apocynin. Leptin increased urinary excretion of hydrogen peroxide (H2O2) between 2 and 3 h of infusion. The effect of leptin on renal Na+,K+-ATPase and urinary H2O2 was augmented by a superoxide dismutase mimetic, tempol, and was abolished by catalase. In addition, infusion of H2O2 for 30 min increased the Na+,K+-ATPase activity. Inhibitors of extracellular signal regulated kinases (ERKs), PD98059 or U0126, prevented Na+,K+-ATPase stimulation by leptin and H2O2. These data indicate that leptin, by acting directly within the kidney, has a delayed stimulatory effect on Na+,K+-ATPase, mediated by JAKs, H2O2 and ERKs. This mechanism may contribute to the abnormal renal Na+ handling in diseases associated with chronic hyperleptinemia such as diabetes and obesity.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 803-809
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nitric oxide - superoxide cooperation in the regulation of renal Na+,K+-ATPase.
Autorzy:
Bełtowski, Jerzy
Marciniak, Andrzej
Jamroz-Wiśniewska, Anna
Borkowska, Ewelina
Powiązania:
https://bibliotekanauki.pl/articles/1041505.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
H+,K+-ATPase
Sch 28080
superoxide anion
Na+,K+-ATPase
nitric oxide
oxidative stress
Opis:
The aim of this study was to investigate whether endogenous superoxide anion is involved in the regulation of renal Na+,K+-ATPase and ouabain-sensitive H+,K+-ATPase activities. The study was performed in male Wistar rats. Compounds modulating superoxide anion concentration were infused under general anaesthesia into the abdominal aorta proximally to the renal arteries. The activity of ATPases was assayed in isolated microsomal fraction. We found that infusion of a superoxide anion-generating mixture, xanthine oxidase (1 mU/min per kg) + hypoxanthine (0.2 μmol/min per kg), increased the medullary Na+,K+-ATPase activity by 49.5% but had no effect on cortical Na+,K+-ATPase and either cortical or medullary ouabain-sensitive H+,K+-ATPase. This effect was reproduced by elevating endogenous superoxide anion with a superoxide dismutase inhibitor, diethylthiocarbamate. In contrast, a superoxide dismutase mimetic, TEMPOL, decreased the medullary Na+,K+-ATPase activity. The inhibitory effect of TEMPOL was abolished by inhibitors of nitric oxide synthase (L-NAME), soluble guanylate cyclase (ODQ) and protein kinase G (KT5823). The stimulatory effect of diethylthiocarbamate was not observed in animals pretreated with a synthetic cGMP analogue, 8-bromo-cGMP. An inhibitor of NAD(P)H oxidase, apocynin (1 μmol/min per kg), decreased the Na+,K+-ATPase activity in the renal medulla and its effect was prevented by L-NAME, ODQ or KT5823. In contrast, a xanthine oxidase inhibitor, oxypurinol, administered at the same dose was without effect. These data suggest that NAD(P)H oxidase-derived superoxide anion increases Na+,K+-ATPase activity in the renal medulla by reducing the availability of NO. Excessive intrarenal generation of superoxide anion may upregulate medullary Na+,K+-ATPase leading to sodium retention and blood pressure elevation.
Źródło:
Acta Biochimica Polonica; 2004, 51, 4; 933-942
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C.
Autorzy:
Bełtowski, Jerzy
Marciniak, Andrzej
Jamroz-Wiśniewska, Anna
Borkowska, Ewelina
Wójcicka, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1041555.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
phosphatidylinositol-3-kinase
protein kinase C
cytochrome P450-dependent arachidonate metabolites
Na+,K+-ATPase
Opis:
We examined the role of protein kinase C (PKC) in the regulation of Na+,K+- ATPase activity in the renal cortex. Male Wistar rats were anaesthetized and the investigated reagents were infused into the abdominal aorta proximally to the renal arteries. A PKC-activating phorbol ester, phorbol 12,13-dibutyrate (PDBu), had a dose-dependent effect on cortical Na+,K+-ATPase activity. Low dose of PDBu (10-11 mol/kg per min) increased cortical Na+,K+-ATPase activity by 34.2%, whereas high doses (10-9 and 10-8 mol/kg per min) reduced this activity by 22.7% and 35.0%, respectively. PDBu administration caused changes in Na+,K+-ATPase Vmax without affecting K0.5 for Na+, K+ and ATP as well as Ki for ouabain. The effects of PDBu were abolished by PKC inhibitors, staurosporine, GF109203X, and Gö 6976. The inhibitory effect of PDBu was reversed by pretreatment with inhibitors of cytochrome P450-dependent arachidonate metabolism, ethoxyresorufin and 17-octadecynoic acid, inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002, and by actin depolymerizing agents, cytochalasin D and latrunculin B. These results suggest that PKC may either stimulate or inhibit renal cortical Na+,K+-ATPase. The inhibitory effect is mediated by cytochrome P450-dependent arachidonate metabolites and PI3K, and is caused by redistribution of the sodium pump from the plasma membrane to the inactive intracellular pool.
Źródło:
Acta Biochimica Polonica; 2004, 51, 3; 757-772
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phenotype modifiers of spinal muscular atrophy: the number of SMN2 gene copies, deletion in the NAIP gene and probably gender influence the course of the disease
Autorzy:
Jędrzejowska, Maria
Milewski, Michał
Zimowski, Janusz
Borkowska, Janina
Kostera-Pruszczyk, Anna
Sielska, Danuta
Jurek, Marta
Hausmanowa-Petrusewicz, Irena
Powiązania:
https://bibliotekanauki.pl/articles/1040639.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
SMN2 gene copy number
SMA modifiers
NAIP deletion
gender influence
Opis:
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by mutations of the SMN1 gene. It is characterized by significant phenotype variability. In this study, we analyzed possible phenotype modifiers of the disease - the size of the deletion in the SMA region, the number of SMN2 gene copies, as well as the effect of gender. Among the factors analyzed, two seem to influence the SMA phenotype: the number of SMN2 gene copies and a deletion in the NAIP gene. A higher number of SMN2 copies makes the clinical symptoms more benign, and the NAIP gene deletion is associated with a more severe phenotype. The influence of gender remains unclear. In a group of 1039 patients, 55% of whom were male, the greatest disproportion was in the SMA1 (F/M = 0.78) and SMA3b (F/M = 0.45) forms. In SMA1 a deletion in the NAIP gene was seen twice as frequently in girls compared to boys. In three patients, we observed genotypes atypical for the chronic forms of SMA: two patients with SMA3a and 3b had a deletion of the NAIP gene, and a third patient with SMA2 had one copy of the SMN2 gene.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 103-108
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 16-28 z 28

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