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Wyświetlanie 1-15 z 23
Tytuł:
Bioavailability of mesalazine from two coated formulation tablets
Autorzy:
Hermann, Tadeusz W.
Główka, Franciszek K.
Hermann, Jacek
Zabel, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/895531.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
bioavailability
human subjects
5-ASA matrix tablets
pharmacokinetic parameters
TopFit computer program
sustained release
Opis:
HPLC methodology with a fluorescent detector is suitable for bioavailability studies of investigated generic tablets Mesalazine 250 mg (Jelfa, Poland) versus standard Salofalk tablets (Dr. Falk, Germany). The investigations were completed in ten healthy subjects in a double way crossover design. Only one bioavailability parameter – time for maximum mesalazine plasma concentration (tmax ) and overall elimination rate constants are significantly greater for the above standard tablets. The parameters like maximum plasma drug concentration (Cmax), lag time for absorption (Tlag), biological half-life time (t1/2 ) are also more favorable for the standard, but these values are not significantly different.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 67-73
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determination of tigecycline in turkey plasma by LC-MS/MS: validation and application in a pharmacokinetic study
Autorzy:
Jasiecka-Mikolajczyk, A.
Jaroszewski, J.J.
Powiązania:
https://bibliotekanauki.pl/articles/32022.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Tigecycline (TIG), a novel glycylcycline antibiotic, plays an important role in the management of complicated skin and intra-abdominal infections. The available data lack any description of a method for determination of TIG in avian plasma. In our study, a selective, accurate and reversed-phase high performance liquid chromatography-tandem mass spectrometry method was developed for the determination of TIG in turkey plasma. Sample preparation was based on protein precipitation and liquid-liquid extraction using 1,2-dichloroethane. Chromatographic separation of TIG and minocycline (internal standard, IS) was achieved on an Atlantis T3 column (150 mm x 3.0 mm, 3.0 μm) using gradient elution. The selected reaction monitoring transitions were performed at 293.60 m/z → 257.10 m/z for TIG and 458.00 m/z → 441.20 m/z for IS. The developed method was validated in terms of specificity, selectivity, linearity, lowest limit of quantification, limit of detection, precision, accuracy, matrix effect, carry-over effect, extraction recovery and stability. All parameters of the method submitted to validation met the acceptance criteria. The assay was linear over the concentration range of 0.01-100 μg/ml. This validated method was successfully applied to a TIG pharmacokinetic study in turkey after intravenous and oral administration at a dose of 10 mg/kg at various time-points.
Źródło:
Polish Journal of Veterinary Sciences; 2017, 20, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Four-Week Intake of Blackthorn Flower Extract on Mice Tissue Antioxidant Status and Phenolic Content
Autorzy:
Balta, Vedran
Đikić, Domagoj
Crnić, Irena
Odeh, Dyna
Orsolic, Nada
Kmetič, Ivana
Murati, Teuta
Dragović Uzelac, Verica
Landeka Jurčević, Irena
Powiązania:
https://bibliotekanauki.pl/articles/1363304.pdf
Data publikacji:
2021
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
pharmacokinetic
flavan-3-ol
flavonoids
bioavailability
phenolic compounds
Prunus spinosa L
Opis:
The study examined the antioxidative physiological effects of phenolics from an ethanol-water extract of blackthorn flowers orally administrated to C57/BL6 mice for 28 days in daily doses of 25 mg of total phenolics/kg body weight. Contents of phenolics in the intestine, liver, and kidneys collected after 1, 7, 14, 21, and 28 days of extract administration were analyzed by UPLC-MS/MS method. In the same tissues, the antioxidative properties were determined as ferric reducing antioxidant power (FRAP), ABTS•+ scavenging activity, content of reduced glutathione (GSH), and activity of superoxide dismutase (SOD) and catalase (CAT). The lipid peroxidation in tissues was also evaluated by thiobarbituric acid reactive substances (TBARS) assay. The exposed mice (compared to the control ones) had a lower content of TBARS in all tissues mostly on the third/fourth week of daily consumption. SOD activity and GSH content increased on the 28th day in tissues. CAT activity was higher only in the liver after one week of consumption but remained unchanged in other organs throughout the experiment. Phenolic profiles were different in individual tissues. The most prominent increases compared to the control were determined for contents of 3-O-feruloylquinic acid, 4-O-p-coumaroylqiunic acid, kaempferol pentoside, and quercetin rhamnoside in the intestine; for ferulic acid and quercetin 3-O-rutinoside in the liver; and for quercetin 3-O-rutinoside, ferulic acid, and 4-O-p-coumaroylquinic acid in the kidneys. The screened phenolics with different distribution in tissues could be responsible for slight differences in the recorded antioxidative effects.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2020, 70, 4; 361-375
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Farmakokinetyczne metody oceny ilościowej profilu metabolicznego witaminy D3
Farmakokineticheskie metody kolichestvennojj ocenki metabolicheskogo profilja vitamina D3
Pharmacokinetic method of quantitative evaluation of the metabolic profile of D3 vitamin
Autorzy:
Kozłowski, K.H.
Lorenc, R.S.
Powiązania:
https://bibliotekanauki.pl/articles/2188295.pdf
Data publikacji:
1980
Wydawca:
Polskie Towarzystwo Diagnostyki Laboratoryjnej
Źródło:
Diagnostyka Laboratoryjna; 1980, 16, 2; 85-97
0867-4043
Pojawia się w:
Diagnostyka Laboratoryjna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
FORMULATION AND IN VIVO PHARMACOKINETIC STUDIES OF ILOPERIDONE DEPOT INJECTION
Autorzy:
Dubey, Vineet
Saini, Tulsi R.
Powiązania:
https://bibliotekanauki.pl/articles/895464.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Iloperidone
in vivo pharmacokinetic studies
in situ depot injection
sucrose acetate isobutyrate
Opis:
Iloperidone is a new antipsychotic agent having a good tolerability and side-effects profile with respect to long term drug administration. Presently, it is only available as tablet dosage forms of 1-12 mg strengths for twice a day administration. This article reports the pharmacokinetic studies of a novel in situ depot injection formulation of iloperidone developed for once a month administration. The formulation is based on the use of sucrose acetate isobutyrate as gelling agent for depot formation in situ. It is simple to prepare, possesses an acceptable syringeability and exhibits a controlled and consistent zero order drug release in vitro for one month. The in vivo pharmacokinetic studies performed in male albino Wistar rats for one month showed a mean peak plasma drug concentration of 871.8 ng/ml in 3 days, mean residence time of 28.9 days, terminal half-life of 24 days, and a terminal elimination rate-constant of 0.0289/day. The plasma concentration profile of the developed formulation demonstrated a persistent plasma level of iloperidone for one month without any significant burst release and with a good in vitro - in vivo correlation.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 59-66
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identifiability and estimation of pharmacokinetic parameters for the ligands of the macrophage mannose receptor
Autorzy:
Verdiere, N.
Denis-Vidual, L
Joly-Blanchard, G.
Domurado, D.
Powiązania:
https://bibliotekanauki.pl/articles/908453.pdf
Data publikacji:
2005
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
układ nieliniowy
identyfikowalność
estymacja parametrów
zastosowania biologiczne
nonlinear systems
identifiability
parameter estimation
biological applications
Opis:
The aim of this paper is numerical estimation of pharmacokinetic parameters of the ligands of the macrophage mannose receptor, without knowing a priori the values of these parameters. However, it first requires a model identifiability analysis, which is done by applying an algorithm implemented in a symbolic computation language. It is shown that this step can lead to a direct numerical estimation algorithm. In this way, a first estimate is computed from noisy simulated observations without a priori parameter values. Then the resulting parameter estimate is improved by using the classical least-squares method.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2005, 15, 4; 517-526
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular docking and pharmacokinetic prediction of phytochemicals from Syzygium cumini in interaction with penicillin-binding protein 2a and erythromycin ribosomal methylase of Staphylococcus aureus
Autorzy:
Shidiki, A.
Vyas, A.
Powiązania:
https://bibliotekanauki.pl/articles/2096259.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
methicillin-resistant S. aureus
penicillin-binding protein 2a
erythromycin ribosomal methylase
Opis:
Background. MRSA and MLSB resistant S. aureus are known as important pathogens, which are responsible for many cases of both hospital and community-acquired infections worldwide. Studying drug discovery from plant sources is regarded as an important prevention strategy regarding these types of infections. Material and methods. Agar well diffusion method was performed for antimicrobial evaluation, LCMS technique used for identification of different compounds, molecular docking performed by application of iGEMDOCK for PBP2a and ERM to plant compounds, and its pharmacokinetic evaluation of ADMET through use of AdmetSAR. Results. Water extract was the most effective against resistant strains of Staphylococcus aureus. Twenty compounds belonging to phenols, flavonoids, organic acids, terpenoids groups were reported. Eighteen plant compounds passed in Lipinski's rule of five. iGEMDOCK revealed diferulic acid has the least binding energy -102.37 kcal/mole to penicillin-binding protein 2a and taxifolin has the least binding energy of -103.12 kcal/mole to erythromycin ribosomal methylase in comparison to control linezolid. These compounds raise the potential for developing potent inhibitors of penicillin-binding protein 2a and erythromycin ribosomal methylase for drug development. ADMET properties revealed that eighteen studied compounds were found in category III and IV with non-toxic properties except two butin and taxifolin found in category II with toxic properties. Conclusions. It can be concluded that diferulic acid and taxifolin compounds provide the best inhibitor effect to PBP2a and ERM protein for inhibition of MRSA and MLSB resistant strains of S. aureus through the application of molecular docking, leading to a lead drug candidate for the treatment of diseases.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2022, 103, 1; 5-18
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Morphological and pharmacokinetic properties of oral solid dietary supplements containing plant extracts
Właściwości morfologiczne i farmakokinetyczne stałych doustnych suplementów diety zawierających ekstrakty roślinne
Autorzy:
Glogowski, A.
Marczynski, Z.
Kolodziejczyk, M.K.
Jambor, J.
Stefan, M.K.
Zgoda, M.M.
Powiązania:
https://bibliotekanauki.pl/articles/71271.pdf
Data publikacji:
2016
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Opis:
Introduction: Dietary supplements are a good way to supplement the deficiency of certain micronutrients and organic components (therapeutic agents) in human body. They are most often available in concentrated form as tablets, capsules, powder or liquid. Objective: To investigate morphological parameters and the pharmaceutical availability of coated tablets – dietary supplements – that contain selected pharmacopeial titrated dry plant extracts. Methods: Testing of the effective time of the tablet surface erosion was performed in model acceptor fluids using pharmacopeial methods in static (Erweka apparatus) and dynamic (unlimited diffusion method) conditions. Furthermore, morphological parameters of tablets (the original shape of an ellipse) as well as their hardness were determined. Results: The effective erosion time was determined by conductometric method using carboxymethylcellulose sodium salt (NaCMC) contained in the tablet. The content of gum arabic and NaCMC in the tablet testifies that the granulate was produced using the “wet granulation” technique which resulted in high hardness of original, esthetic, elliptical tablets and in prolonged disintegration time (erosion). Conclusions: The used excipients: gum arabic and NaCMC for the production of the tested tablets containing selected dry plant extracts result in their high hardness. The tested dietary supplements are characterized by esthetic design, original shape, and prolonged disintegration time which affects the pharmaceutical availability.
Wstęp: Suplementy diety to dobry sposób na uzupełnianie braków niektórych mikroelementów i składników organicznych (środków leczniczych) w organizmie człowieka. Najczęściej są oferowane w postaci skoncentrowanej jako tabletki, kapsułki proszek lub płyn. Cel: Celem pracy było zbadanie parametrów morfologicznych i dostępności farmaceutycznej tabletek powlekanych, suplementów diety, które zawierają wybrane farmakopealne mianowane suche ekstrakty roślinne. Metody: Metodami farmakopealnymi w modelowych płynach biorczych przeprowadzono badania nad efektywnym czasem erozji powierzchniowej tabletek w warunkach statycznych (urz. Erweka) i dynamicznych (metodą nieograniczonej dyfuzji). Ponadto oznaczono parametry morfologiczne tabletek (oryginalny kształt elipsy) i ich twardość. Wyniki: Wykorzystując zawartość w masie tabletkowej soli sodowej karboksymetylocelulozy (NaCMC), metodą konduktometryczną wyznaczono efektywny czas erozji. Zawartość w masie tabletkowej gumy arabskiej i NaCMC świadczy o tym, że granulat przygotowano metodą „na mokro”, co przekłada się na wysoką twardość oryginalnych, estetycznych tabletek o eliptycznym kształcie i wydłużony czas rozpadu (erozji). Wnioski: Zastosowane substancje pomocnicze – guma arabska i NaCMC (sól sodowa karboksymetylocelulozy) – do wytworzenia badanych tabletek, zawierających wybrane suche ekstrakty roślinne, powodują ich wysoką twardość. Przebadane wybrane suplementy diety charakteryzują się estetycznym wyglądem i oryginalnym kształtem oraz wydłużonym czasem rozpadu, co wpływa na dostępność farmaceutyczną.
Źródło:
Herba Polonica; 2016, 62, 3
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New insight into organic anion transporters from the perspective of potentially important interactions and drugs toxicity
Autorzy:
Mor, A.L.
Kaminski, T.W.
Karbowska, M.
Pawlak, D.
Powiązania:
https://bibliotekanauki.pl/articles/70038.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
organic anion transporter
transmembrane transporter
drug-drug interaction
central nervous system
glycosylation
herbal preparation
dietary supplement
pharmacokinetic interaction
Źródło:
Journal of Physiology and Pharmacology; 2018, 69, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
No effect of3-(N-p-isopropoxyphenylsuccinimidomethylamino)-cinnamic acid on anticonvulsant action of different classical antiepileptic drugs in mouse maximal electroshock-induced seizure model
Autorzy:
Luszczycki, J. J.
Marczewski, T.
Marzeda, E.
Durmowicz, D.
Podgorska, D.
Kocharov, S. L.
Florek-Luszczki, M.
Powiązania:
https://bibliotekanauki.pl/articles/972739.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Tematy:
antiepileptic drugs
maximal electroshock-induced seizures
pharmacokinetic/pharmacodynamic interaction
p-isopropoxyphenylsuccinimide derivative
Opis:
Introduction and objective: The aim of the study was to determine the effects of 3-(N-p-isopropoxyphenylsuccinimidomethylamino)-cinnamic acid (IPPSMA-CA – a new succinimide derivative) on the protective action of 4 classical antiepileptic drugs (AEDs): carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]), against maximal electroshock (MES)-induced tonic seizures in mice. Materials and methods: Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via auricular electrodes. Acute adverse-effectprofiles of the combination of IPPSMA-CA and 4 classical AEDs (CBZ, PB, PHT and VPA) with respect to motor performance, long-term memory and skeletal muscular strength were measured in the chimney, passive avoidance and grip-strength tests, respectively. Results: IPPSMA-CA administered at 150 mg/kg (i.p.) significantly elevated the threshold for electroconvulsions in mice (p<0.01). IPPSMA-CA at doses of 50 and 100 mg/kg, however, had no significant impact on the threshold for electroconvulsions in mice. Nor did IPPSMA-CA (100 mg/kg) significantly affect the anticonvulsant activity of CBZ, PB, PHT and VPA in the MES test in mice. None of the examined combinations of IPPSMA-CA (100 mg/kg, i.p.) with CBZ, PB, PHT and VPA (at their ED50 values from the MES-induced seizure test) affected motor coordination in the chimney test, long-term memory in the passive avoidance task, and muscular strength in the grip-strength test in mice. This indicates no possible acute adverse effects in animals. Conclusions: IPPSMA-CA elevated the threshold for electroconvulsions in mice in a dose-dependent manner. However, IPPSMA-CA at a sub-protective dose of 100 mg/kg did not affect the anticonvulsant action of various classical AEDs in the mouse MES model. Thus, the combinations of IPPSMA-CA with CBZ, PB, PHT and VPA are neutral from a preclinical viewpoint.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2012, 06, 1; 20-24
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition
Autorzy:
Kraszewski, A.
Romanowska, J.
Szymanska-Michalak, A.
Sobkowski, M.
Boryski, J.
Stawinski, J.
Lipniacki, A.
Piasek, A.
Powiązania:
https://bibliotekanauki.pl/articles/81225.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
nucleotide analogue
phosphorylation
HIV
viral disease
physicochemical property
pharmacokinetic parameter
anti-HIV activity
antiviral pro-nucleotide
patent
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2014, 95, 4
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Observer design estimating the propofol concentration in PKPD model with feedback control of anesthesia administration
Autorzy:
Ilyas, Muhammad
Khan, Awais
Khan, Muhammad Abbas
Xie, Wei
Riaz, Raja Ali
Khan, Yousaf
Powiązania:
https://bibliotekanauki.pl/articles/2106507.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pharmacokinetic models
pharmacodynamic model
bispectral index monitor
observer design
sliding mode control
Opis:
Propofol infusion in anesthesia administration requires continual adjustment in the manual infusion system to regulate the hypnosis level. Hypnotic level is based on Bispectral Index Monitor (BIS) showing the cortical activity of the brain scaled between 0 to 100. The new challenging aspect of automation in anaesthesia is to estimate the concentration of hypnotic drugs in different compartments of the body including primary, rapid peripheral (muscle), slow peripheral (bones, fat) and effect site (brain) compartment based on Pharmacokinetics (PK) and Pharmacodynamics (PD) model. This paper aimed to regulate the hypnosis level with estimating the Propofol concentrations using a linear observer in feedback control strategy based on Integral Super-Twisting Sliding Mode Controller (ISTSMC). The drug concentration in plasma of the silico patients accurately estimated in nominal transient. The results show that tracking errors between the actual output in form of BIS level and linearized output nearly approaches to zero in the maintenance phase of anesthesia to ensure the controller response on sliding phase with optimum performances by achieving desired hypnotic level 50 on BIS. The robustness of control strategy is further ensured by adding measurement noise of electromagnetic environment of operation theatre distracting signal quality index of the output BIS level.
Źródło:
Archives of Control Sciences; 2022, 32, 1; 85--103
1230-2384
Pojawia się w:
Archives of Control Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
PHARMACOKINETIC INTERACTION AFTER ORAL COADMINISTRATION OF CLARITHROMYCIN AND THE TYROSINE KINASE INHIBITOR LAPATINIB IN RATS
Autorzy:
Karbownik, Agnieszka
Porażka, Joanna
Łuczak, Anna
Teżyk, Artur
Grabowski, Tomasz
Wolc, Anna
Grześkowiak, Edmund
Szałek, Edyta
Powiązania:
https://bibliotekanauki.pl/articles/895581.pdf
Data publikacji:
2019-08-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 645-651
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmacokinetic profiles of 5 mg/kg ibudilast, a phosphodiesterase inhibitor, orally administered to dogs in fasted and non-fasted states. A preliminary study.
Autorzy:
Łebkowska-Wieruszewska, B.
De Vito, V.
Kowalski, C.J.
Owen, H.
Poapolathep, A.
Lisowski, A.
Giorgi, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087742.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pharmacokinetics
ibudilast
dog
non-selective cyclic nucleotide phosphodiesterase inhibitor
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 2; 281-285
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmacokinetics of the recombinant ovine interferon-tau in lambs
Autorzy:
Zhao, J.
Yu, H.Y.
Zhao, Y.
Li, S.Q.
Fu, X.L.
Zhou, W.
Xia, B.B.
Wang, M.L.
Chen, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087588.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bioavailability
ovine interferon-τ
cytopathic effect inhibition assay
pharmacokinetic study
Źródło:
Polish Journal of Veterinary Sciences; 2019, 1; 75-82
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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