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Wyświetlanie 1-15 z 515
Tytuł:
Role of genetic modification of the PNPLA3 gene in predicting metabolically unhealthy obesity and metabolic associated fatty liver disease in children
Autorzy:
Abaturov, Aleksandr
Nikulina, Anna
Powiązania:
https://bibliotekanauki.pl/articles/2207159.pdf
Data publikacji:
2023-03-25
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
children
metabolic associated fatty liver disease
obesity
patatin‐like phospholipase domain‐containing protein 3
single nucleotide variants
Opis:
Introduction and aim. Single nucleotide variants (SNV) of the patatin‐like phospholipase domain‐containing protein 3 (PNP-LA3) gene play an important role in hepatic lipid remodeling and lipogenesis de novo, which is associated with the development of metabolically unhealthy obesity (MUO) and metabolic associated fatty liver disease (MAFLD). The aim of the study was to define the contribution of SNV PNPLA3 gene to the development of MUO, complicated by MAFLD in children. Material and methods. 200 obese children aged 6-18 years were examined. The main group (n=118) was represented by children with MUO. The control group (n=82) consolidated of children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat) was performed in 31 children of the main and 21 children of the control group. Results. Among obese children, 14 variants of SNV PNPLA3 (rs139051, rs34179073, rs2294918, rs139047, rs779127153, rs2076212, rs738409, rs738408, rs4823173, rs2072906, rs2076213, rs141106484, rs138736228) were identified, including SNV PNPLA3 g.44322818, not described in the dbSNP core database. The role of the following SNV PNPLA3 genotypes in the development of MUO complicated by MAFLD was revealed: rs738409 C/G (Relative risk (RR)=1.71); rs738408 C/T (RR=1.71); rs4823173 G/A (RR=1.57); rs2072906 A/G (RR=1.57) with Sensitivity (Se)=0.63 and Specificity (Sp)=0.72. Conclusion. The contribution to the development of MUO complicated by MAFLD in children is made by the linked association of genotypes: rs738409 C/G, rs738408 C/T, rs4823173 G/A and rs2072906 A/G out of 14 PNPLA3 SNVs diagnosed by us.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 1; 5-13
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ preparatu białkowo-ksantofilowego PX z lucerny (Medicago sativa L.) na aktywność wybranych enzymów w komórkach wątroby tuczników
The effect of protein-xanthophyll concentrate (PX) from alfalfa (Medicago sativa L.) on the activity of selected enzymes in the liver cells of fattening pigs
Autorzy:
Abramowicz, K.
Krauze, M.
Grela, E.R.
Powiązania:
https://bibliotekanauki.pl/articles/843823.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Zootechniczne
Tematy:
trzoda chlewna
zywienie zwierzat
dodatki paszowe
lucerna
koncentrat bialkowo-ksantofilowy
watroba
enzymy
dehydrogenaza mleczanowa
dehydrogenaza jablczanowa
dehydrogenaza bursztynianowa
hydrolaza glukozo-6-fosforanowa
aktywnosc enzymatyczna
Opis:
W dostępnej literaturze krajowej i zagranicznej prezentowane są nieliczne doniesienia na temat aktywności enzymów wskaźnikowych, zwłaszcza markerowych, charakteryzujących pracę konkretnych organelli komórkowych. Ubogie są również informacje na temat zmian aktywności enzymów, jakie zachodzą pod wpływem żywieniowych czynników doświadczalnych. W doświadczeniu założono, że koncentrat białkowo-ksantofilowy PX z lucerny pozytywnie wpłynie na metabolizm, czego efektem będzie poprawa wskaźników produkcyjnych u tuczników. Celem badań było zatem sprawdzenie możliwości wykorzystania niestosowanych dotąd enzymów w ocenie poprawności zachodzących procesów biochemicznych po podaniu PX. Oceniano aktywność enzymów związanych z kluczowymi przemianami biochemicznymi zachodzącymi w komórce, co pozwala na ocenę poprawności zachodzących procesów, jak i reakcji ustroju na czynniki zewnętrzne. Doświadczenie przeprowadzono na 288 tucznikach (loszkach i wieprzkach) mieszańcach (wbp x Neckar), podzielonych na 4 grupy, zróżnicowane pod względem dawki i okresu podawania koncentratu białkowo-ksantofilowego PX z lucerny (Medicago sativa L.). Koncentrat z lucerny wprowadzono do mieszanki paszowej w miejsce poekstrakcyjnej śruty sojowej. Analizowano aktywność wybranych enzymów markerowych: dehydrogenazy mleczanowej (LDH), jabłczanowej (MDH), bursztynianowej (SDH) oraz hydrolazy glukozo-6-fosforanowej (G6PC). Wykazano obniżenie aktywności analizowanych enzymów w komórkach wątroby u zwierząt otrzymujących dodatek koncentratu PX w porównaniu do zwierząt z grupy kontrolnej, co sugeruje korzystny wpływ zastosowanego preparatu na przemiany metaboliczne u badanych zwierząt. Wyniki doświadczenia potwierdzają celowość stosowania w żywieniu świń koncentratu białkowo-ksantofilowego PX z lucerny, zwłaszcza w dawce 3% podawanej w sposób ciągły.
The available Polish and foreign literature contains few reports on the activity of indicator enzymes, especially marker enzymes, which characterize the work of specific cell organelles. Information on enzyme changes induced by experimental dietary factors is also scarce. We postulated that proteinxanthophyll PX alfalfa concentrate would have a positive effect on metabolism in fattening pigs, resulting in improved performance parameters. Therefore the aim of the study was to test the possibility of using enzymes that have not previously been used to assess the biochemical processes taking place following administration of PX. We evaluated the activity of enzymes associated with key biological transformations taking place in the cell, as this makes it possible to assess whether these processes are proceeding normally and to evaluate the response of the body to external factors. The experiment was conducted on 288 finishers (gilts and barrows), all of which were crossbreds (Polish Large White x Neckar), divided into 4 groups according to the dosage and duration of administration of proteinxanthophyll PX concentrate from alfalfa (Medicago sativa L.). The alfalfa concentrate was introduced to the compound feed in place of soybean extraction meal. We analysed the activity of selected marker enzymes: lactate dehydrogenase (LDH), malate dehydrogenase (MDH), succinate hydrolase (SDH), and glucose-6-phosphate hydrolase (G6PC). We found a decrease in the activity of the enzymes in the liver cells of the pigs receiving the PX concentrate as compared to the control, which suggests that the product had a favourable effect on their metabolism. The results confirm the benefit of using proteinxanthophyll PX in pig feed, particularly at a continuous dose of 3%.
Źródło:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego; 2017, 13, 2
1733-7305
Pojawia się w:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials
Autorzy:
Adisa, Rahmat
Sulaimon, Lateef
Powiązania:
https://bibliotekanauki.pl/articles/1038594.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Plasmodium berghei
Artecxin
Lonart
P-Alaxin
Chloroquine
oxidative stress
mitochondrial membrane fluidity
Opis:
The present study was aimed at determining and comparing the effects of Artecxin (ART), P - Alaxin (P-ALA), Lonart (LON) and Chloroquine (CQ) on oxidative stress parameters and mitochondrial membrane composition in the course of malaria infection. Six groups of five mice each categorized as healthy control (non-parasitized non-treated group), parasitized-non-treated (PnT), parasitized-chloroquine-treated (positive control), parasitized-Artecxin, -Lonart and -P-Alaxin-treated groups were used for the study. Hepatic antioxidant status was assessed with levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as activity of superoxide dismutase (SOD) and catalase (CAT) in the post mitochondrial and mitochondrial fractions. Mitochondrial membrane integrity was also evaluated with activity of succinate dehydrogenase and levels of phospholipids, cholesterol and proteins in the liver mitochondria. Results revealed that treatment of parasitized mice with the antimalarial drugs significantly (p<0.05) decreased hepatic malondialdehyde (MDA) and mitochondrial membrane phospholipids compared to parasitized untreated group. On the other hand, significantly (p<0.05) elevated succinate dehydrogenase (SDH) activity, mitochondrial membrane cholesterol level, GSH concentration, catalase (CAT) and superoxide dismutase (SOD) activity in the post mitochondrial fraction were obtained. Thus, antimalarial drugs distort mitochondrial membrane integrity and electron transfer but reduce the malaria-induced oxidative stress on the host.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 485-491
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of probiotic supplementation as alternative therapy for NAFLD: a literature review
Autorzy:
Adnan, Muhammad Luthfi
Powiązania:
https://bibliotekanauki.pl/articles/1891281.pdf
Data publikacji:
2021-12-02
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
Non-alcoholic fatty liver disease
NAFLD
probiotic
therapy
Opis:
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, influenced by various risk factors associated with metabolic disorders. Currently there is no specific effective treatment for NAFLD. Probiotics have been extensively researched for their health benefit Probiotic Supplementation for NAFLD. Methods: A simple literature review was performed based on searches via PubMed, ScienceDirect and Google Scholar, using the keywords "probiotic," "microbiota," "non-alcoholic fatty liver disease," "metabolic disorder," and "therapy." Results: Research on the use of probiotics for NAFLD demonstrated improvement in liver function and histology. However, the literature is inconsistent regarding the probiotics’ influence on the NAFLD risk factors. Probiotics can be an alternative therapy for NAFLD through the ability to modulate the microbiota of the gastrointestinal tract. Conclusion: Probiotics can be an alternative therapy in NAFLD patients, however more extensive studies are needed to ensure the safety of this approach.
Źródło:
European Journal of Translational and Clinical Medicine; 2021, 4, 2; 75-85
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dual Application of Al-Kheriat of Removal of Arsenic from Aqueous Solution and Acting as Rodenticide
Autorzy:
Al-Jendeel, Haider Abdulkareem
Rasheed, Hala Abdulkareem
Ahmedzeki, Nada Sadoon
Alhassani, Maha Hadi
Powiązania:
https://bibliotekanauki.pl/articles/24201659.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
arsenic
biosorbent
rodenticide
green process
Al-Kheriat
liver enzyme
Opis:
Arsenic is a prevalent and pervasive environmental contaminant with varied amounts in drinking water. Arsenic exposure causes cancer, cardiovascular, liver, nerve, and ophthalmic diseases. The current study aimed to find the best conditions for eliminating arsenic from simulated wastewater and their effect on biomarkers of hepatic in mice. Adsorption tests including pH, contact duration, Al-kheriat dosage, and arsenic concentrations were evaluated. Seventy-two healthy albino mice (male) were accidentally allocated into nine groups (n = 8), the first group was considered as healthy control, the second group (AL-Kheriat), and other groups received AL-Kheriat and arsenic 25, 50, 75, 100, 125, 150 and 175 mg/kg, respectively. Next 10 days, the following were examined: LD50 level, ALP (alkaline phosphatase), ALT (alanine aminotransferase), and AST (aspartate aminotransferase), besides the histological condition of the liver. The results showed that the best time for arsenic removal was 4 hours, pH 8, Alkheriat dose 1 gram, and 50 ppm of pollutants. The level of alkaline phosphatase ALP, alanine transaminase ALT, and aspartate transaminase AST was increased to 150.96 (U/L), 143.1(U/L), and 32.8(U/L), respectively, in Al-Khriet and arsenic exposed population than the healthy control group, When the appropriate dose of Al-Khriet and arsenic mixture is used, it can aid in the selection of a safe way of disposing of the adsorbed residue. Additionally, it can serve as a low-cost rodent pesticide, increasing the commercial viability of this removal strategy.
Źródło:
Journal of Ecological Engineering; 2023, 24, 4; 16--26
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antioxidant status and hepato-protective role of Anchomanes difformis in streptozotocin-induced diabetes in male Wistar rats
Autorzy:
Alabi, T.D.
Brooks, N.L.
Oguntibeju, O.O.
Powiązania:
https://bibliotekanauki.pl/articles/2049053.pdf
Data publikacji:
2020
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
Anchomanes difformis
antioxidants
diabetes
hyperglycaemia
hyperlipidaemia
liver
antyoksydanty
cukrzyca
hiperglikemia
hiperlipidemia
wątroba
Opis:
Introduction: The liver is involved in the metabolism of xenobiotics and their metabolites and it is vulnerable to oxidative damage. Hyperglycaemia is highly implicated in the progression of diabetes mellitus, and adversely affects the liver. Though, conventional hypoglycaemic drugs may be effective in reducing blood glucose, they do not appear to be effective in attenuating the progression of diabetes and its complications. Objective: This study evaluated the ameliorative effects of Anchomanes difformis on hyperglycaemia and hepatic injuries in type 2 diabetes. Methods: Type 2 diabetes was induced in male Wistar rats with a single intraperitoneal injection of streptozotocin (40 mg/kg BW) after two weeks of fructose (10%) administration. Aqueous extract of A. difformis (200 and 400 mg/kg BW) and glibenclamide (5 mg/kg BW) were administered orally for six weeks. Blood glucose concentrations were measured. Serum levels of liver dysfunction markers (ALT, AST, and ALP), total cholesterol, triglycerides, HDL- and LDL-cholesterol were investigated. Total protein, albumin, and globulin were also assessed. Antioxidant parameters: ORAC, GSH, GSSG, SOD, CAT and FRAP were evaluated in the liver while ORAC, FRAP and lipid peroxidation were determined in the serum. Histological examination of the liver tissue was carried out. Results: Treatment with aqueous extract of A. difformis significantly (p<0.05) reduced blood glucose and reversed steatosis in the diabetic-treated rats. The antioxidant status of diabetic-treated rats was significantly (p<0.05) improved. Serum levels of liver dysfunction markers were significantly (p<0.05) reduced in diabetic-treated rats. Conclusion: The findings in this study revealed that 400 mg/kgBW Anchomanes difformis was more effective than 200 mg/kg BW in ameliorating diabetes-induced hepatopathy, however, both doses of Anchomanes difformis demonstrated more antidiabetic ability than glibenclamide. Anchomanes difformis may be a novel and potential therapeutic agent in the management of diabetes and resulted hepatic injuries.
Źródło:
Herba Polonica; 2020, 66, 1; 18-36
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationships between certain metabolic diseases and selected serum biochemical parameters in seropositive dairy cows against Neospora caninum infection in different stages of lactation
Autorzy:
Alekish, Myassar O.
Talafha, Abdelsalam Q.
Alshehabat, Musa A.
Bani Ismail, Zuhair A.
Powiązania:
https://bibliotekanauki.pl/articles/972115.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Neospora caninum
BHB
liver enzymes
ketosis
dairy cows
Opis:
Neospora caninum is an important cause of abortion in dairy cattle. The general health of affected cows has not been investigated before. Therefore, the main objective of this study was to identify possible relationships between certain metabolic diseases and selected serum biochemical parameters in seropositive dairy cows against N. caninum antibodies in different stages of lactation. The study was carried out using 72 N. caninum seropositive cows and 61 seronegative dairy cows (control). Serum from all cows was tested to determine their N. caninum status (seropositive vs seronegative) using commercially available indirect enzyme-linked immunosorbent assay test kit (iELISA). In addition, serum biochemical parameters including beta-hydroxybutyrate (BHB), glucose, creatinine, blood urea nitrogen, total protein, albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH) and gamma-glutamyltranspeptidase (GGT) were determined using routine laboratory methods. The stage of lactation was obtained at the time of sampling from farm records. Student independent t-test showed that there was a significant difference in the serum concentrations of BHB, AST, ALT, and LDH between seropositive and seronegative cows. There was no significant association between seropositivity and the stage of lactation. However, multivariable logistic regression analysis showed that there was a strong association between seropositivity and BHB concentrations. Results of this study indicate a possible relationship between N. caninum seropositivity and certain metabolic diseases such as ketosis and fatty liver syndrome in dairy cows.
Źródło:
Annals of Parasitology; 2017, 63, 2; 99-103
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on in vitro toxicity of biometal(II) Monensinates against rat Zajdela liver tumour
Autorzy:
Alexandrova, Radostina
Zhivkova, Tanya
Ivanov, Dimitar
Andonova-Lilova, Boika
Dyakova, Lora
Pantcheva, Ivayla
Dorkov, Peter
Powiązania:
https://bibliotekanauki.pl/articles/1430283.pdf
Data publikacji:
2020
Wydawca:
Towarzystwo Chemii i Inżynierii Ekologicznej
Tematy:
chemically-induced rat tumour of Zajdelа
bone marrow cells
Monensin A biometal(II) complexes
cytotoxic effect
antiproliferative effect
chemicznie indukowany guz Zajdela u szczurów
komórki szpiku kostnego
Monenzyna A
działanie cytotoksyczne
działanie antyproliferacyjne
Opis:
The ability of Monensic acid A (MonH∙H2O) and its neutral metal complexes [M(Mon)2(H2O)2]with ions of Mg2+, Ca2+, Mn2+, Co2+, Ni2+ and Zn2+ to decrease viability and proliferation of primary cell cultures, originating from a chemically induced transplantable liver tumour of Zajdela in rats, and bone marrow cells from the same tumour-bearers, was evaluated. Experimental data revealed that manganese(II) and nickel(II) complexes of Monensin A are relatively more selective against the tumour as compared to the healthy bone marrow cells.
Źródło:
Chemistry-Didactics-Ecology-Metrology; 2020, 25, 1-2; 125-132
2084-4506
Pojawia się w:
Chemistry-Didactics-Ecology-Metrology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine on liver fibrosis in carbon tetrachloride-induced rats
Autorzy:
Altay, Derya
Dogan, Yasar
Orhan, Cemal
Tuzcu, Mehmet
Sahin, Nurhan
Ozercan, Ibrahim
Sahin, Kazım
Powiązania:
https://bibliotekanauki.pl/articles/895409.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
N-acetylcysteine
carbon tetrachloride
liver fibrosis
Ashwagandha
Tribulus terrestris
Opis:
Background and Aim: Fibrosis, which develops during the progression of liver damage, is the previous stage of cirrhosis. Carbon tetrachloride is one of the most commonly used hepatic toxins in experimental animal models of liver fibrosis. It was investigated the hepatoprotective effects of Tribulus terrestris, Ashwagandha and N-acetylcysteine in an experimental model of liver fibrosis induced by carbon tetrachloride in this study. Methods: Fifty Wistar rats were divided into five groups of 10 each, as follows: 1) control, 2) carbon tetrachloride, 3) carbon tetrachloride plus N-acetylcysteine, 4) carbon tetrachloride plus T. terrestris, and 5) carbon tetrachloride plus Ashwagandha group. At the end of 6 weeks, the rats were sacrificed, and serum and tissue samples were collected. Aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, malondialdehyde, NF-κB, collagen 1, nuclear factor erythroid-2-related factor 2, tumor necrosis factor-α were analyzed, and histopathological evaluation was performed. Results: There were no significant differences in serum aspartate aminotransferase and alanine aminotransferase levels of the N-acetylcysteine-treated group versus those in the T. terrestris- and Ashwagandha-treated groups (p>0.05). Liver malondialdehyde levels were lower in the N-acetylcysteine-, T. terrestris- and Ashwagandha-treated groups than in the carbon tetrachloride-administered group (p<0.001). There were differences between groups in NF-κB, collagen 1, nuclear factor erythroid-2-related factor 2 and tumor necrosis factor-α levels (p<0.05). Conclusions: In conclusion, T. terrestris, Ashwagandha and N-acetylcysteine had protective effects on the liver in this experimental fibrosis model. T.Terrestris was a little more effective than Ashwagandha in combating liver fibrosis.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 805-813
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pozostalosci chlorowanych weglowodorow w watrobach noworodkow, niemowlat i dzieci
Autorzy:
Amarowicz, R
Sulik, M.
Korczakowska, B.
Brykalska, A.
Powiązania:
https://bibliotekanauki.pl/articles/877353.pdf
Data publikacji:
1993
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
niemowleta
weglowodory chloropochodne
noworodki
dzieci
toksykologia
metabolity
DDT
insektycydy
watroba
infant
chlorinated hydrocarbon
neonate
child
toxicology
metabolite
insecticide
liver
Opis:
W wątrobach zmarłych 4 noworodków, 2 niemowląt i 2 dzieci oznaczono poziom pozostałości chlorowanych węglowodorów.
In the liver of 4 newborns, 2 infants and 2 children the levels of residues of chlorinated hydrocarbons were determined .The highest levels of ƩHCH (817 mcg/kg of fat, 17.1 mcg/kg of tissue) were found in a 2-day-old newborn, the lowest ones (43 mcg/kg of fat, 1.8 mcg/kg of tissue) were m an infant aged 12 months. The content of ƩDDT was highest (3044 mcg/kg of fat, 93.8 mcg/kg of tissue) in the liver of an infant aged 13 days, the lowest values (322 mcg/kg of fat, 5.6 mcg/kg of tissue) in the liver of a child aged 12 years. The results are comparable to those obtained in this country in the liver of adults and in human placenta.
Źródło:
Roczniki Państwowego Zakładu Higieny; 1993, 44, 4; 379-382
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zawartość chlorowanych węglowodorów w tłuszczu, wątrobach i mięsie wieprzowym
SODERZHANIE KHLORIROWANNYKH UGLEWODOROW W SWINEM SALE PECHENIJAKH I SWININE
CHLORINATED HYDROCARBONS IN PIG FAT, LIVER AND PORK
Autorzy:
Amarowicz, R.
Olender, B.
Smoczynski, S.
Powiązania:
https://bibliotekanauki.pl/articles/874743.pdf
Data publikacji:
1988
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
weglowodory chlorowane
tluszcze
przetwory miesne
produkty spozywcze
zanieczyszczenia chemiczne
Źródło:
Roczniki Państwowego Zakładu Higieny; 1988, 39, 3
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mechanism of action of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide on homoterm animals and humans
Autorzy:
Antonenko, A.M.
Blagaia, A.V.
Omelchuk, S.T.
Korshun, M.M.
Vavrinevych, H.P.
Milohov, D.S.
Pelo, I.M.
Bojar, I.
Powiązania:
https://bibliotekanauki.pl/articles/3635.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
4-hydroxyphenylpyruvatedioxygenase
herbicide
homotherm animal
man
tyrosinemia
tyrosine aminotransferase
target organ
corneal capacity
liver
thyroid gland
Opis:
It was found that the main mechanisms of action of 4-hydroxyphenylpyruvatedioxygenase inhibitors are the development of tyrosinemia and alternations in thyroid hormone level as a result of hepatic enzyme induction. The main target organs of its action are the eyes, liver and thyroid gland. It was proved that the most adequate model for extrapolation of the effects of tyrosinemia on humans are mice, because their tyrosine aminotransferase activity level is similar to that in humans.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zawartość wybranych składników mineralnych w wątrobie żubrów w różnym wieku
The content of the selected mineral components in the liver of the European bisons at different age
Autorzy:
Arkuszewska, E.
Lozicki, A.
Dymnicka, M.
Olech, W.
Gipsiak, J.
Petruczenko, D.
Powiązania:
https://bibliotekanauki.pl/articles/843940.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Zootechniczne
Opis:
Materiał badawczy stanowiły próbki wątroby pobrane od 25 żubrów, wyeliminowanych w ramach corocznych odstrzałów selekcyjno-redukcyjnych przeprowadzonych w Puszczy Białowieskiej w latach 2005-2007. Oznaczono zawartość makroelementów i wybranych mikroelementów w wątrobach żubrów w różnym wieku, które porównano z wartościami referencyjnymi dla bydła oraz z wynikami wcześniejszych badań prowadzonych w Puszczy Białowieskiej. Zawartość analizowanych makro- i mikroelementów w wątrobie, we wszystkich grupach wiekowych żubrów, mieściła się w granicach wartości przyjmowanych za fizjologiczne dla bydła, z wyjątkiem Cu. Nie stwierdzono potwierdzonych statystycznie różnic dotyczących wpływu wieku na zawartość makro- i mikroelementów w wątrobach żubrów. W latach 2005-2007 zawartość Ca, P, Na, Mg, Mn i Zn w wątrobach żubrów była wyższa, zawartość K zbliżona, natomiast Cu i Co niższa w porównaniu do wyników badań z lat 1998- -2003. Wykazana w badaniach własnych zawartość Cu w wątrobach żubrów ze wszystkich grup wiekowych wskazuje na niedobór kliniczny tego pierwiastka, co stwierdzono również badaniach w latach 1998-2003.
The research material included liver samples, collected from 25 European bisons eliminated during the annual selection – reduction shooting, conducted in the Białowieża Forest in the years 2005-2007. The aim of the work was to analyze the content of macroelements and the selected microelements in the liver of the European bison, depending on age, as compared to the reference values for cattle and the results of earlier studies, conducted in the Białowieża Forest. The content of the analyzed macro- and microelements in the liver in all age groups of the bisons was found within the limits of values, adopted as physiological ones for cattle, except for Cu. Any statistically confirmed differences concerning the effect of the age on the contents of micro- and macroelements in the liver of the European bison were not recorded. The levels of Ca, P, Na, Mg, Mn and Zn in the livers of the bisons, as studied in the years 2005-2007 were higher, K similar, Cu and Co were lower as compared to the results of the studies, conducted in the years 1998-2003. The contents of Cu, as determined in the livers of all age groups of the bison in own studies indicate clinical deficiency of the discussed element, which occurred also in the years 1998-2003.
Źródło:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego; 2012, 08, 4
1733-7305
Pojawia się w:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA adducts detected by synchronous fluorescence spectrophotometry in rat liver, kidney, lung and spleen after intraperitoneal administration of benzo[a]pyrene
Autorzy:
Baer-Dubowska, Wanda
Kulińska, Aleksandra
Jarmuż, Małgorzata
Brauze, Damian
Gnojkowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1045508.pdf
Data publikacji:
1993
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1993, 40, 1; 63-65
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 515

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