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Wyszukujesz frazę "liver" wg kryterium: Wszystkie pola


Tytuł:
History of liver transplantation in Poland
Autorzy:
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1392651.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
liver transplantations
history of liver transplantation
liver transplant centers in Poland
liver transplantation technique
Opis:
Experimental research on liver transplantation was introduced in Poland by Waldemar Olszewski and his team in 1972. Not until 15 years later, in 1987, did Stanisław Zieliński in Szczecin and Marian Pardela in Katowice make an attempt of transplanting liver in humans. In 1989 another attempt was made by Jacek Pawlak and Marek Krawczyk in Warsaw. The first successful liver transplantation in Poland was performed in 1990 by Piotr Kaliciński at the Children’s Memorial Health Institute, Warsaw. Also, in early 1990s the attempts were made by Jerzy Polański in Warsaw and Piotr Szyber in Wrocław. In the next years, liver transplantations were connected with three centers in Szczecin and were associated with the following persons: Roman Kostryka, Maciej Wójcicki and Samir Zeaira. In Warsaw, 1994, Jacek Pawlak, Bogdan Michałowicz and Krzysztof Zieniewicz performed another successful liver transplantation. The program started to develop rapidly and is still up and running. In 2000, Wojciech Rowiński and Marek 
Pacholczyk created another liver transplant center in Warsaw, while in 2005 Lech Cierpka and Robert Król did the same in Katowice. In the following years, liver transplantation was initiated by Maciej Słupski in Bydgoszcz (2017) and Zbigniew Śledziński in Gdańsk (2018). In the developing liver transplant centers, an exceptional contribution was made by Paweł Nyckowski, Jacek Pawlak, Krzysztof Zieniewicz, Waldemar Patkowski, Tadeusz Wróblewski, Rafał Paluszkiewicz, Marek Pacholczyk, Andrzej Chmura, Maciej Kosieradzki and Marek Krawczyk – all employed by the Medical University of Warsaw. In Wrocław, Dariusz Patrzałek and Paweł Chudoba were very active in the field of liver transplantations. In 1996, the Organizing-Coordinating Center for Transplantation POLTRANSPLANT was brought to life and at first was directed by Janusz Wałaszewski, then by Roman Danielewicz and Artur Kamiński. In 1999, Piotr Kaliciński and Marek Krawczyk started the program for liver fragment harvesting and transplantation from living donors. Until the end of 2016, 4186 liver transplantations including 314 liver transplants from living donors were performed in Poland. Currently there are three active centres in Warsaw, namely Pediatric Surgery and Transplantation Surgery, Children’s Memorial Health Institute; Department of General, Transplant and Liver Surgery, Medical University of Warsaw; 
Department of General and Transplant Surgery, Medical University of Warsaw. Other active centres in Poland are Department of General and Transplant Surgery, Provincial Hospital in Szczecin, Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Department of Vascular, General and Transplant Surgery in Wrocław. Liver transplant programs have also been initiated at the Department of Liver and General Surgery, Bydgoszcz, and Department of General, Endocrine and Transplant Surgery, Medical University of Gdańsk.
Źródło:
Polish Journal of Surgery; 2018, 90, 3; 60-68
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Early results of liver resection using laparoscopic technique
Autorzy:
Stranek, Maciej
Pędziwiatr, Michał
Radkowiak, Dorota
Zychowicz, Anna
Budzyński, Piotr
Major, Piotr
Budzyński, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1394071.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
laparoscopy
liver resection
liver metastases
Opis:
The aim of the study was to present early outcomes of liver resection using laparoscopic technique. Material and methods. Retrospective analysis of patients who underwent liver resection using laparoscopic method was conducted. The analyzed group included 23 patients (11 women and 12 men). An average patient age was 61.3 years (37 – 83 years). Metastases of the colorectal cancer to the liver were the cause for qualification to the procedure of 15 patients, metastasis of breast cancer in 1 patient and primary liver malignancy in 5 patients. The other 2 patients were qualified to the liver resection to widen the surgical margins due to gall-bladder cancer diagnosed in the pathological assessment of the specimen resected during laparoscopic cholecystectomy, initially performed for other than oncology indications. Results. Hemihepatectomy was performed in 11 patients (9 right and 2 left), while the other 12 patients underwent minor resection procedures (5 metastasectomies, 4 nonanatomical liver resections, 1 bisegmentectomy, 2 resections of the gall-bladder fossa). An average duration of the surgical procedure was 275 minutes 65 – 600). An average size of the resected tumors was 28 mm (7 – 55 mm). In three cases conversion to laparotomy occurred, caused by excessive bleeding from the liver parenchyma. Postoperative complications were found in 4 patients (17.4%). Median hospitalization duration was 6 days (2 – 130 days). One patient (4.3%) was rehospitalized due to subhepatic abscess and required reoperation. Histopathology assessment confirmed radical resection (R0) in all patients in our group. Conclusion. Laparoscopic liver resections seem to be an interesting alternative in the treatment of focal lesions in the liver.
Źródło:
Polish Journal of Surgery; 2016, 88, 1; 20-25
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of the zearalenone on the activity of chosen liver enzymes in a rat
Autorzy:
Stadnik, A
Borzecki, A.
Powiązania:
https://bibliotekanauki.pl/articles/51110.pdf
Data publikacji:
2009
Wydawca:
Instytut Medycyny Wsi
Tematy:
rat
liver
enzyme
enzyme activity
zearalenone
mycotoxin
Fusarium
liver cell
Źródło:
Annals of Agricultural and Environmental Medicine; 2009, 16, 1; 31-35
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cartilaginous compression of the liver – clinical and ultrasonographic aspects
Autorzy:
Smereczyński, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1033246.pdf
Data publikacji:
2018
Wydawca:
Medical Communications
Tematy:
costal cartilages
liver
muscles
pseudolesions
ultrasonography
Opis:
Introduction: The musculocartilaginous complex is a structure composed of cartilaginous, osseous and muscular elements, which is located at the thoracoabdominal junction, at the level of the right costal arch. Aim: To determine the ultrasonographic characteristics of this complex under normal conditions as well as to demonstrate its effects on the liver depending on the constitutional body built, respiratory phase and patient’s body position. Materials and methods: All abdominal ultrasound scans were performed between 2006 and 2015. A total of 1000 patients (566 females and 434 males aged between 35 and 82 years, mean age 52 years), who had no significant upper abdominal pathologies identified based on clinical and imaging data, were enrolled for the analysis. In addition to standard internal organ assessment, we also attempted to identify the symptoms of hepatic compression by the musculocartilaginous complex. We used 3–6 MHz convex and 7–12 MHz linear transducers. The degree of musculocartilaginous compression of the liver was assessed during breathing in supine and sitting position, as well as with trunk inclined forward. Results: The study showed that musculocartilaginous compression of the liver mostly affects females (96%) with leptosomatic body build. The complex compressing the liver shows a heterogeneous echostructure. Increased hepatic compression was observed during exhalation, in a sitting position and with trunk inclined forward. Conclusions: Cartilaginous compression of the liver depends on body built and patient’s body position. The musculocartilaginous complex may cause focal or segmental compression of the hepatic parenchyma, causing pain in the right upper abdomen in some patients.
Wprowadzenie: Kompleks chrząstkowo-mięśniowy to struktura składająca się z elementów chrzęstnych, kostnych i mięśniowych, zlokalizowana na pograniczu piersiowo-brzusznym, na poziomie prawego łuku żebrowego. Cel: Określenie ultrasonograficznych cech tego kompleksu w warunkach prawidłowych oraz wykazanie jego wpływu na wątrobę w zależności od budowy konstytucjonalnej, fazy oddechowej oraz pozycji przyjmowanej przez pacjenta. Materiał i metoda: Wszystkie badania ultrasonograficzne jamy brzusznej przeprowadzono w okresie od 2006 do 2015. Do analizy zakwalifikowano 1000 osób (566 kobiet i 434 mężczyzn, w przedziale wiekowym 35–82 lata, średnio 52 lata), u których na podstawie danych klinicznych i obrazowych nie stwierdzono istotnych zmian w narządach nadbrzusza. W badaniach ultrasonograficznych jamy brzusznej, oprócz standardowo ocenianych narządów wewnętrznych, skupiono się na poszukiwaniu objawów ucisku wątroby przez kompleks chrząstkowo-mięśniowy. Do badań wykorzystywano głowice konweksowe o częstotliwości 3–6 MHz oraz liniowe o częstotliwości 7–12 MHz. Stopień ucisku wątroby przez kompleks chrząstkowo-mięśniowy oceniano w trakcie oddychania, w ułożeniu pacjenta na plecach, w pozycji siedzącej i w przodopochyleniu tułowia. Wyniki: Wykazano, że ucisk chrząstkowopochodny wątroby dotyczy głównie kobiet (96%) o budowie leptosomicznej. Uciskający wątrobę kompleks najczęściej wykazuje heterogeniczną echostrukturę. Większy stopień ucisku wątroby występował w trakcie wydechu, w pozycji siedzącej i w przodopochyleniu tułowia. Wnioski: Ucisk chrząstkowopochodny wątroby jest uzależniony od budowy ciała oraz przyjmowanej przez pacjenta pozycji. Kompleks chrząstkowo-mięśniowy może wywierać ucisk ogniskowy lub odcinkowy na miąższ wątroby, powodując u części osób ból w prawym nadbrzuszu. Artykuł w wersji polskojęzycznej jest dostępny na stronie http://jultrason.pl/index.php/wydawnictwa/volume-18-no-72
Źródło:
Journal of Ultrasonography; 2018, 18, 72; 9-15
2451-070X
Pojawia się w:
Journal of Ultrasonography
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin
Autorzy:
Panoutsopoulos, Georgios
Beedham, Christine
Powiązania:
https://bibliotekanauki.pl/articles/1041506.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
xanthine oxidase
phthalazine
aldehyde oxidase
liver slices
disulfiram
isovanillin
allopurinol
Opis:
The enzymes aldehyde oxidase and xanthine oxidase catalyze the oxidation of a wide range of N-heterocycles and aldehydes. These enzymes are widely known for their role in the metabolism of N-heterocyclic xenobiotics where they provide a protective barrier by aiding in the detoxification of ingested nitrogen-containing heterocycles. Isovanillin has been shown to inhibit the metabolism of aromatic aldehydes by aldehyde oxidase, but its inhibition towards the heterocyclic compounds has not been studied. The present investigation examines the oxidation of phthalazine in the absence and in the presence of the inhibitor isovanillin by partially purified aldehyde oxidase from guinea pig liver. In addition, the interaction of phthalazine with freshly prepared guinea pig liver slices, both in the absence and presence of specific inhibitors of several liver oxidizing enzymes, was investigated. Aldehyde oxidase rapidly converted phthalazine into 1-phthalazinone, which was completely inhibited in the presence of isovanillin (a specific inhibitor of aldehyde oxidase). In freshly prepared liver slices, phthalazine was also rapidly converted to 1-phthalazinone. The formation of 1-phthalazinone was completely inhibited by isovanillin, whereas disulfiram (a specific inhibitor of aldehyde dehydrogenase) only inhibited 1-phthalazinone formation by 24% and allopurinol (a specific inhibitor of xanthine oxidase) had little effect. Therefore, isovanillin has been proved as an inhibitor of the metabolism of heterocyclic substrates, such as phthalazine, by guinea pig liver aldehyde oxidase, since it had not been tested before. Thus it would appear from the inhibitor results that aldehyde oxidase is the predominant enzyme in the oxidation of phthalazine to 1-phthalazinone in freshly prepared guinea pig liver slices, whereas xanthine oxidase only contributes to a small extent and aldehyde dehydrogenase does not take any part.
Źródło:
Acta Biochimica Polonica; 2004, 51, 4; 943-951
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection
Autorzy:
Hołówko, Wacław
Grąt, Michał
Wronka, Karolina Maria
Stypułkowski, Jan
Roszkowski, Rafał
Studnicki, Paweł
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1395543.pdf
Data publikacji:
2015-02-01
Wydawca:
Index Copernicus International
Tematy:
colorectal liver metastases
liver resection
total tumor volume
Opis:
Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease. The aim of the study was to evaluate the predictive value of total tumor volume, size and number of colorectal liver metastases in patients treated with right hemihepatectomy. Material and methods. A retrospective analysis was performed in a group of 135 patients with colorectal liver metastases, who were treated with right hemihepatectomy. Total tumor volume was estimated based on the formula (4/3)πr3. Moreover, the study included an analysis of data on the number and size of tumors, radicality of the resection, time between primary tumor resection and liver resection, pre-operative blood serum concentration of carcinoembryonal antigen (CEA) and carcinoma antigen Ca19-9. The predictive value of the factors was evaluated by applying a Cox proportional hazards model and the area under the ROC curve. Results. The univariate analysis has shown the predictive value of size of the largest tumor (p=0.033; HR=1.065 per each cm) on the overall survival, however no predictive value of number of tumors (p=0.997; HR=1.000) and total tumor volume (p=0.212; HR=1.002) was observed. The multivariate analysis did not confirm the predictive value of the size of the largest tumor (p=0.141; HR=1.056). In the analysis of ROC curves, AUROC for the total tumor volume, the size of the largest tumor and the number of tumors were 0.629, 0.608, 0.520, respectively. Conclusions. Total tumor volume, size and number of liver metastases are not independent risk factors for the worse overall survival of patients with colorectal liver metastases treated with liver resection, therefore increased values of these factors should not be a contraindication for surgical treatment
Źródło:
Polish Journal of Surgery; 2015, 87, 2; 53-58
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Arginase isoenzymes in human cirrhotic liver
Autorzy:
Chrzanowska, Alicja
Gajewska, Beata
Barańczyk-Kuźma, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1040542.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
arginase activity
liver cirrhosis
isoenzyme expression
Opis:
Cirrhosis leads to an inability of the liver to perform its biochemical functions. It can also lead to hepatocellular carcinoma in which, as we showed lately, arginase isoenzyme pattern changes. The present work presents our results on arginase isoenzymes and their possible role in liver cirrhosis. The study was performed on tissues obtained during liver transplantation from 60 patients with liver cirrhosis, and on samples of histologically normal liver (control) from 40 patients with benign or colorectal cancer liver metastases removed during surgery, 6-7 cm from the tumor border. Arginase isoenzymes AI (so-called liver-type arginase) and AII (called extrahepatic arginase) were identified by Western blotting and isolated by ion-exchange chromatography. Their expression on mRNA level was studied by RT-PCR. A significant decrease in arginase activity, dependent of the liver clinical stage, was observed in cirrhotic tissue. Arginase AI activity and its mRNA level were significantly decreased in cirrhotic liver, whereas the activity and expression of arginase AII were concurrently raised, as compared to normal liver. Since arginase AI is a key enzyme of the urea cycle, whereas arginase AII most probably takes part in the biosynthesis of ornithine and polyamines, the defective ammonia inactivation and increased collagen biosynthesis observed in cirrhotic liver may be related to the changes in arginase AI and AII levels, respectively.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 465-469
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contrast-enhanced ultrasonography (CEUS) in canine liver examination
Autorzy:
Wdowiak, M.
Rychlik, A.
Nieradka, R.
Nowicki, M.
Powiązania:
https://bibliotekanauki.pl/articles/31671.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
contrast-enhanced ultrasonography
canine liver
examination
liver
dog
ultrasonography
cancer
diagnostics
imaging technique
Opis:
Ultrasonography is a noninvasive diagnostic tool used to image size, shape, parenchyma and vascularization of various body organs. Unfortunately, the ultrasonographic image is characterized by a low contrast due to similar acoustic properties of the soft tissue. The Doppler mode provides information about blood flow, but is incapable of imaging small vessels and capillaries because of their low blood flow velocity (1 mm/s). However, a possibility to increase the effectiveness of ultrasonographic diagnostics exists, thanks to intravenous ultrasound contrast agents (UCAs) consisted of gas microbubbles. The purpose of this review paper is to characterize specific imaging techniques necessary to conduct a contrast-enhanced liver examination and indications for CEUS as an alternative diagnostic method.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Features of pharmacotherapy of hepatic encephalopathy manifestations in liver cirrhosis
Autorzy:
Maretskyi, V.
Lobanets, N.
Powiązania:
https://bibliotekanauki.pl/articles/2052423.pdf
Data publikacji:
2015
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
hepatic encephalopathy
liver cirrhosis
psychometric test
Opis:
The aim of this work is to study the effect of drug mebikar on the clinical manifestations of hepatic encephalopathy in patients with liver cirrhosis. The study involved 34 patients with cirrhosis of different etiologies. The average age of the examined patients was (48.5±0.9) years, that prevailed patients of working age, indicating the medical and social significance of the problem of early diagnosis and adequate treatment of cirrhosis. One of the most frequent complications of cirrhosis is hepatic encephalopathy. In addition to conventional clinical and laboratory findings in patients with liver cirrhosis, severities of hepatic encephalopathy were determined according to West-Haven criteria before and after treatment. In patients with liver cirrhosis was established the presence of latent or clinically expressed hepatic encephalopathy. The treatment of the control group of patients consisted of the following drugs: essential phospholipids, mixture of sorbitol and major ions, arginine glutamate, furosemide, verospiron, lactulose, amoxicillin trihydrate and lansoprazole. In the complex treatment of the main group of patients medicine mebikar was administered additionally. Analysis of the clinical manifestations of hepatic encephalopathy showed a marked improvement in patients who received additional treatment with mebikar. Specifically, the incidences of mood changes as well as anxiety decreased in this group on average of 38% compared with those patients without an additional treatment with mebikar. Also, sleep disturbances in the main group was observed to be lower by 7.2% compared to those in the control group. Inclusion in the treatment of patients with liver cirrhosis, the drug mebikar – a daytime tranquilizer with anxiolytic properties reduces neurotic disorders, improves emotional state which may indicate a regression in the manifestations of hepatic encephalopathy thereby improving the quality of life of patients and thus substantiating an expedient inclusion of mebikar an anxiolytic drug to the complex therapy of patients with liver cirrhosis.
Źródło:
Health Problems of Civilization; 2015, 09, 2; 31-34
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ultrasonography as a diagnostic and prognostic approach in cattle and buffaloes with fatty infiltration of the liver
Autorzy:
Tharwat, M.
Powiązania:
https://bibliotekanauki.pl/articles/30512.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ultrasonography
diagnostics
prognosis
cattle
buffalo
fatty infiltration
liver
fatty liver
hepatic lipidosis
lipid metabolism
dairy cow
Opis:
The aim of the present study was to determine whether ultrasonographic evaluation of the hepatic parenchyma could be used as a diagnostic and prognostic approach in cows and buffaloes with hepatic lipidosis. For this purpose, cows (n=16) and buffaloes (n=10) with fatty infiltration of the liver were examined by ultrasonography. Treated cows and buffaloes were monitored for hepatic changes ultrasonographically, biochemically and histologically. Clinical findings were non-specific and included anorexia, recumbency, muzzle necrosis, and icteric mucosal membranes. Laboratory data revealed neutrophilia, hyper γ-globulinemia, elevated activities of aspartate aminotransferase, γ-glutamyl transpeptidase, creatine kinase and lactate dehydrogenase, and high concentrations of insulin, total bilirubin, non-esterified fatty acids and β-hydroxyl butyric acid. Laboratory results 7, and 21 days after treatment showed progressive improvement in the chemistry profile. On admission, ultrasonographic examination of the hepatic parenchyma in cows and buffaloes revealed either increased or decreased hepatic echogenicity; histologic examination revealed marked fatty infiltration of the hepatocytes. One week after treatment, the hepatic parenchyma was visualized easily, liver boundaries were clearly imaged, and histologic examination of hepatic specimen showed a moderate degree of fatty infiltration. Three weeks after treatment, the hepatic parenchyma was almost similar to normal, the hepatic and portal blood vessels could be easily imaged, and the histologic picture had greatly improved where the liver resembled the normal organ. Six cows and seven buffaloes made a full recovery while the remaining ten cows and three buffaloes were slaughtered and thoroughly examined postmortem. Ultrasonography showed a good correlation with histologic and laboratory findings.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Post-transplant Metabolic Syndrome (PTMS) after Liver Transplantation – Review of the Literature
Autorzy:
Kotarska, Katarzyna
Raszeja-Wyszomirska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1054740.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
liver transplantation
metabolic syndrome
Opis:
Liver transplant provides a definitive therapeutic measure for patients with chronic and acute liver diseases. Apart from the improvement of overall health, an organ transplant entails several metabolic complications. They are multi-agent and depend, among others, on the function of organ being transplanted, adverse effects of immunosuppression being applied, organ complications induced by failure of the organ being transplanted, current treatment, concomitant diseases and consequences of the acute and chronic rejection processes. Improvements in surgical techniques, peritransplant intensive care, and immunosuppressive regimens have resulted in significant improvements in short-term survival. Focus has now shifted to address long-term outcomes of liver transplantation. Therefore, this paper presents the current review of literature referring to specificity of the prevalence of metabolic syndrome and its complications in patients after liver transplantation.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2015, 11, 3; 29-37
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fatty liver disease in dairy cattle – risk factors, symptoms and prevention
Autorzy:
Bombik, E.
Sokol, J.
Pietrzkiewicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/2119575.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Zootechniczne
Tematy:
dairy cattle
metabolic disease
fatty liver
Opis:
Fat cow syndrome (fatty liver disease) is a common metabolic problem in dairy cow production during the transition period, from the dry period to lactation. This syndrome occurs when due to liver uptake of non-esterified fatty acids (NEFAs), they are stored in excess as triacylglycerols (TAGs) in the liver. Currently, diagnosis of this disorder must be confirmed by a liver biopsy to determine the fat content of liver cells, as well as blood tests for increased levels of liver enzymes (GGT, SDH, AST, and bilirubin). Fat cow syndrome is associated with the occurrence of clinical diseases, decreased immunity, and problems with reproduction. It is a major problem in the herd health due to the high cost of veterinary services, a longer calving interval, and reduced longevity of cows, causing enormous economic losses. The best means of prevention is good nutrition and routine blood tests in the herd.
Źródło:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego; 2020, 16, 4; 51-58
1733-7305
Pojawia się w:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Perspectives of pharmacological intervention promoting liver regeneration
Perspektywy farmakologicznej interwencji w promowaniu regeneracji wątroby
Autorzy:
Danilova, Irina
Kalota, Hanna
Abidov, Musa
Powiązania:
https://bibliotekanauki.pl/articles/2097693.pdf
Data publikacji:
2018-06-22
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
terapia komórek macierzystych
przeprogramowanie makrofagów
farmakoterapia chorób wątroby
regeneracja wątroby
liver regeneration
stem cells therapy
macrophage reprogramming
pharmacotherapy of liver diseases
Opis:
Effective drug therapy promoting liver regeneration is a challenging goal in pharmacotherapy of liver diseases. Several plant phytochemicals recommended in traditional medicine from over hundred plants have been investigated for its use in various liver disorders. Regeneration of injured liver depend on a proliferative potential of mature hepatocytes as well as different subsets of intrahepatic and extrahepatic stem/progenitor cells. In clinical trials a stem cell therapy resulted in a limited improvement of liver functions. Animal studies have demonstrated the involvement of bone marrow-derived stem/progenitor cells in liver regeneration. For this reason, the pharmacological activation of endogenous stem cells and pharmacological control of macrophage phenotypic polarization could be an effective method of mobilizing progenitor cells to injured liver.
Wyzwaniem dla współczesnej farmakoterapii są skuteczne leki wspomagające regenerację wątroby. Wiele substancji z ponad stu roślin zalecanych w tradycyjnej medycynie przebadano w celu ich zastosowania w chorobach wątroby. W procesie regeneracji wątroby biorą udział subpopulacje wewnątrz-wątrobowych i poza-wątrobowych komórek macierzystych/progenitorowych oraz dochodzi do proliferacji dojrzałych hepatocytów. Dane kliniczne wskazują na ograniczoną skuteczność terapii komórek macierzystych w polepszeniu funkcji wątroby. W badaniach modeli zwierzęcych regeneracji wątroby wykazano udział komórek macierzystych/ progenitorowych, pochodzących ze szpiku kostnego. Z tego powodu, rozważa się możliwość wprowadzenia farmakologicznej aktywacji endogennych komórek macierzystych oraz farmakologiczną kontrolę fenotypowej polaryzacji makrofagów, jako skutecznej metody mobilizacji komórek progenitoworych dla uszkodzonej wątroby.
Źródło:
Health Promotion & Physical Activity; 2018, 2, 1; 1-4
2544-9117
Pojawia się w:
Health Promotion & Physical Activity
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevalence of non-alcoholic fatty liver disease and hypercholesterolemia in patients with gallstone disease undergoing laparoscopic cholecystectomy
Autorzy:
Singh, Kaptan
Dahiya, Divya
Kaman, Lileswar
Das, Ashim
Powiązania:
https://bibliotekanauki.pl/articles/1391850.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
dyslipidemia
gallstone disease
liver biopsy
non-alcoholic fatty liver disease (NAFLD)
Opis:
Background: Gallstone disease (GSD) and nonalcoholic fatty liver disease (NAFLD) are connected with a high prevalence in the general population and they share common risk factors for their occurrence. Limited literature with inconsistent results is available, suggesting a potential association between these lifestyle-induced diseases. Liver biopsy is the gold standard for diagnosing NAFLD. The aim of this study was (1) to identify the prevalence of asymptomatic NAFLD or NASH in liver biopsy; (2) to identify the association of hypercholesterolemia with NAFLD in patients undergoing laparoscopic cholecystectomy (LC). Methods: This is a prospective observational study conducted on patients who underwent LC for symptomatic gallstones in the Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, from 1st July 2013 to 31st December 2014. All included patients had ultrasonography (USG) and the following parameters tested: serum triglycerides (TG), cholesterol, low density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). A wedge liver biopsy was obtained from free edge of the right liver lobe during LC and all biopsy specimens were analyzed by a single pathologist. Results: Among 101 patients included in the study, dyslipidemia was present in 49.50%. There was no association between NAFLD and serum cholesterol, TG or LDL-C (P, 0.428, 0.848, 0.371 respectively). NAFLD was confirmed in liver biopsy in 21.8% of patients but none had fibrosis or cirrhosis on biopsy. No complications were observed following liver biopsy. Conclusions: Liver biopsy during LC gives an opportunity to diagnose the disease at an early and reversible stage. It is feasible, safe and cost effective.
Źródło:
Polish Journal of Surgery; 2020, 92, 1; 18-22
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neutrophil-lymphocyte ratio and mean platelet volume as predictive factors for liver fibrosis and steatosis in patients with chronic hepatitis B
Autorzy:
Pokora-Rodak, A.
Kiciak, S.
Tomasiewicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/2081973.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
neutrophil-lymphocyte ratio
hepatitis B
liver fibrosis
liver steatosis
Opis:
Objective. Evaluation of the neutrophil-lymphocyte ratio and mean platelet volume as predictive factors for liver fibrosis and steatosis in HBV patients qualified for antiviral treatment. Materials and method. The study comprised 38 CHB patients who had commenced antiviral treatment, and 20 healthy volunteers who constituted the clinical control group. All patients had their blood count taken and underwent hepatic assessment using transient elastography with CAP (controlled attenuation parameter). Results. It was found that the mean hepatic fibrosis was 8.7 kPa (±8.8) and the mean liver steatosis – 286 db/m (±64). Mean NLR – 2.78(±1.1), whereas in the control group the mean NLR value was 1.64(±0.98). A negative linear correlation (r= -0.34; p=0.035) was found between liver fibrosis and the NLR value in the study group. No correlation was observed between hepatic steatosis and the NLR. Mean MPV – 12.6fl (±3.1), which was considerably higher in the CBH patients than in the control group. A positive correlation (r= 0.79, p= 0.001) was found between MPV and disease severity evaluated with transient elastography. Conclusions. The NLR and the MPV were significantly higher in the CHB patients than in the healthy volunteers. Both the NLR and the MPV can be treated as predictive factors for liver fibrosis in this group of patients.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 690-692
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quality of life and physical activity after liver transplantation. Literature review
Autorzy:
Stępień-Słodkowska, Marta
Niewiadomska, Monika
Kotarska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1054800.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
quality of life
liver transplantation
physical activity
Opis:
Liver transplantation has become one of the most effective treatments for end-stage renal disease. For patients, however, the decision to have orthotopic liver transplantation (OLT) is often made in an effort to improve their quality of life and to reduce their risk of mortality and morbidity. Quality of life is an important aspect of therapy for transplant patients because this category reflects the subjective evaluation of one's own life in the physical, psychological and social dimensions. One of the means to achieve a better quality of life is not only good health, but also physical activity. Physical activity has been demonstrated to be of significance not only in the assessment of fitness levels but also could be of importance in long term recovery process after major surgical operations. The aim of this study was a review of literature showing the improved quality of life in patients after liver transplantation as well as the influence of physical activity on their physical health, mental health and quality of life after transplantation. Longitudinal data showed remarkable improvement of common domains of QOL comparing pre- and post-transplant items. Gender, occupation and regular physical activity have an influence on the quality of life after liver transplantation.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2017, 17, 1; 51-60
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cadmium in pork and poultry liver in southern Poland
Autorzy:
Kleszcz, K.
Jędryka, W.
Powiązania:
https://bibliotekanauki.pl/articles/93156.pdf
Data publikacji:
2018
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
cadmium
atomic absorption
animal liver
kadm
absorpcja atomowa
wątroba zwierzęca
Opis:
Samples of pork and poultry livers (ten samples of each type, purchased in southern Poland) were analyzed in order to determine the cadmium concentration. Wet digestion of the samples was carried out and the concentration of cadmium was measured by means of graphitefurnace atomic absorption spectrometry (GF-AAS). The mean values for pork and poultry livers were 79.3 µg/kg and 165.3 µg/kg, respectively. In one sample of poultry liver the Cd concentration was 1043 µg/kg, which is much more than the legal limit for the European Union (500 µg/kg). Statistical analysis showed that there was no significant difference in Cd concentration between the two groups of the samples, unless the highest result (1043 µg/kg) was considered an outlier.
Źródło:
Science, Technology and Innovation; 2018, 3, 2; 9-12
2544-9125
Pojawia się w:
Science, Technology and Innovation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus
Autorzy:
Valdovska, A.
Pilmane, M.
Powiązania:
https://bibliotekanauki.pl/articles/30104.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Aleutian disease
Aleutian mink disease parvovirus
animal infection
beta-defensin-2
histopathology
immunohistochemistry
liver
liver parenchyma
mink
nerve growth factor receptor
metalloproteinase
Opis:
Parvovirus of Aleutian disease causes mainly damage to kidneys, but immune complexes deposition and damage may occur also in other organs. In mink farms of Latvia the liver dystrophy or hepatic lipidosis of mink is widely distributed. The goal of this study was to examine probability of liver damage and regeneration of mink infected with Aleutian disease virus. Liver injury was assessed histologically. The mink liver demonstrated inflammation of liver parenchyma and foci of fatty liver. In immunohistochemistry, during liver regeneration the matrix metalloproteinases MMP-9, vascular endothelial growth factor and β-defensin 2 expressions were lower, but MMP-2 and nerve growth factor receptor p75 expression was increased.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The time of maintainance of positive serologic results among patients operated on echinococcal liver cysts
Autorzy:
Kondrusik, M.
Pancewicz, S.A.
Zajkowska, J.M.
Hermanowska-Szpakowicz, T.
Snarska, J.
Powiązania:
https://bibliotekanauki.pl/articles/840257.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
positive serologic result
patient
cyst
echinococcosis
liver cyst
echinococcal liver cyst
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of Outcomes and Treatment Safety of Patients with Metastatic Colorectal Cancer to the Liver with Estimation of Prognostic Factors
Autorzy:
Zeman, Marcin
Maciejewski, Adam
Półtorak, Stanisław
Kryj, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/1396271.pdf
Data publikacji:
2013-06-01
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer liver metastases
liver resection
neutrophil to lymphocyte ratio
fibrinogen
Opis:
Liver resection is essential part of colorectal cancer liver metastases (CLM) treatment. Mean 5-year overall survival after resection achieves 30-45%. There are many factors influencing long-term outcomes, and among them the inflammatory response to tumor plays an important role. The aim of the study was evaluation of outcomes and treatment safety of patients with metastatic colorectal cancer to the liver with estimation of prognostic factors. Material and methods. 130 consecutive patients (70 men and 60 women) operated in MSC Institute and Cancer Center in Gliwice from 2001 to 2009 due to colorectal liver metastases were analysed. Age of the patients ranged from 33 to 82 years (median 60 years). 96 (74%) patients underwent potentially radical resection, and in remaining 34 (26%) was performed radiofrequency ablation (RFA) alone or combined with the resection. In the resection group 37 right hepatectomies, 11 left hepatectomies, 28 segmentectomies and 20 metastasectomies were performed. Disease-free survival (DFS) and overall survival (OS) were statistically analysed using the Kaplan-Meier method. Factors determining DFS and OS were analysed using Cox regression model. Results. In the resection group the 3- and 5-years OS was 64,5% and 46,6% respectively, and the 3- and 5-years DFS was 32% and 30,5% respectively. In the RFA group the 3- and 5-years OS was 33% and 9,5%. Statistically significant prognostic factors in the resection group in uni- and multivariate analysis were: grade and nodal involvement of the primary tumor, diameter of metastatic focus, positive and narrow (<1 mm) resection margins, preoperative fibrinogen level, preoperative neutrophil to lymphocyte ratio and leukocyte amount of the peripheral blood. The perioperative mortality rate was 3%. Conclusions. Liver resection due to colorectal liver metastases is a safe and effective method resulting in high survival rates. We confirmed some generally accepted prognostic factors influencing longterm outcomes and shown the impact of inflammatory response. We also confirmed the hypothesis that preoperative plasma fibrinogen level influences outcomes after liver resection due to CLM.
Źródło:
Polish Journal of Surgery; 2013, 85, 6; 333-339
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A prospective, interventional clinical study to evaluate the safety and efficacy of Liv.52 DS in the management of non-alcoholic fatty liver disease
Autorzy:
Siregar, Gontar
Paramesh, Rangesh
Kumawat, Rajesh
D, Palaniyamma
HA, Srikrishna
Powiązania:
https://bibliotekanauki.pl/articles/2038171.pdf
Data publikacji:
2021-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
ALT/AST
fatty liver
fibrosis
non-alcoholic fatty liver disease
Opis:
Introduction. Non-alcoholic fatty liver disease (NAFLD) is excessive fat build-up in the liver due to causes other than alcohol use. Aim. To evaluate the clinical efficacy and safety of Liv.52 DS tablets in the management of NAFLD. Material and methods. Prospective, interventional clinical study conducted on 60 patients of both sex, aged between 18-65 years, confirmed with NAFLD from clinical examination, laboratory test, ultrasound findings and those willing to give informed consent. All patients received Liv.52 DS at a dose of 2 tablets twice daily for 2 months. All patients were evaluated at baseline, end of 1st month, and end of 2nd month for liver function tests, hepatomegaly by ultrasound, NAFLD Fibrosis Score, lipid profile, hematology and biochemical investigations. Results. Study data was analyzed with GraphPad Prism Software Version 6.07. Data of those patients who completed the study was considered for analysis. Significant improvement in hepatomegaly, liver enzymes was observed. NAFLD fibrosis score revealed no progression of liver fibrosis due to NAFLD during the study period. No abnormal lab values were recorded and there were no adverse events reported during the study. Conclusion. Study concludes that Liv.52 DS is safe and beneficial in individuals suffering from NAFLD.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 2; 129-136
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical evaluation of seven children with liver Echinococcus granulosus cysts
Autorzy:
Kacprzak, E.
Stefaniak, J.
Lemke, A.
Powiązania:
https://bibliotekanauki.pl/articles/836724.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
Echinococcus granulosus
cyst
echinococcosis
child
liver cyst
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Podstawy etiopatogenezy procesu włóknienia wątroby
Basics of pathogenesis of liver firosis
Autorzy:
Gutkowski, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/437961.pdf
Data publikacji:
2012
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Włóknienie wątroby
macierz zewnątrzkomórkowa
komórki gwiaździste
metaloproteinazy
Liver firosis
extracellular matrix
stellate cells
metalloproteinases
Opis:
Włóknienie wątroby jest zło- żonym procesem biochemicznym, w którym uszkodzone obszary tkanki wątrobowej zostają otoczone przez macierz zewnątrzkomórkową z wytworzeniem tkanki bliznowatej. Proces ten rozwija się u pacjentów z przewlekłymi chorobami wątroby i jest uzależniony od rodzaju schorzenia i właściwo- ści osobniczych. Najwcześniej ulegają uszkodzeniu obszary, w których czynnik sprawczy uzyskuje największe stężenie, szczególnie u chorych z chorobą alkoholową i wirusowymi zapaleniami wątroby. Do rozwoju włóknienia dochodzi zwykle po wielu miesiącach lub latach działania czynnika uszkadzającego. Dokładny przedział czasowy, w którym włóknienie staje się nieodwracalne nie jest znany, jakkolwiek pojawiają się kolejne badania dowodzące, że nawet zaawansowane jego stadia mogą ulec regresji. Rozwikłanie mechanizmów molekularnych zaangażowanych w proces włóknienia posiada szereg implikacji klinicznych. Jedną z najistotniejszych jest tworzenie leków opóźniają- cych lub odwracających ten proces. W pracy przedstawiono aktualny stan wiedzy na temat kluczowych mechanizmów leżących u podłoża procesu włóknienia wątroby.
Liver firosis is a complicated biochemical process in which damaged regions of the liver tissue are encapsulated by an extracellular matrix with scar formation. It develops in all patients with chronic liver injury at variable rates depending in part upon the cause of liver disease and in part upon the host factors. This process occurs earliest in regions where injury is most severe, particularly in chronic inflmmatory liver diseases due to alcohol or viral infection. The development of firosis usually requires several months to years of ongoing injury. The exact point in which firosis becomes irreversible is unknown however, increasing evidence suggests that even advanced stages of fibrosis may be reversible. An understanding of the molecular mechanisms involved in firogenesis process has a number of clinical implications. One of the most important is development of therapeutic interventions designed to impede or reverse hepatic firosis. This review discusses the current mechanisms underlying liver firosis.
Źródło:
Medical Review; 2012, 4; 402-409
2450-6761
Pojawia się w:
Medical Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Porcine model in the laparoscopic liver surgery training
Autorzy:
Komorowski, Andrzej
Mituś, Jerzy
Sanchez Hurtado, Miguel Angel
Sanchez Margallo, Francisco Miguel
Powiązania:
https://bibliotekanauki.pl/articles/1394344.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
laparoscopic liver resection
porcine model
laparoscopic training
Opis:
The aim of the study was to evaluate the possibility to use live anesthetized pigs as a model for laparoscopic liver resection. During two days laparoscopy course two trainees were operating on two live animals performing exposure of the liver, Pringle manoeuver, division of liver ligaments, dissecting of the structures inside the hepatoduodenal ligament, dissection of the hepatic veins and left lateral liver sectionectomy. Exposure of the liver and Pringle manoeuver were performed correctly within 50 and 35 minutes. Left lateral sectionectomy has been performed correctly within 2 hours. The full dissection of the hepatoduodenal ligament and exposure of the hepatic veins were judged as insufficient by experienced laparoscopic tutors. There was one injury to the suprahepatic vena cava that was managed laparoscopically. The porcine model can be used as an advanced training for laparoscopic liver surgery.
Źródło:
Polish Journal of Surgery; 2015, 87, 8; 425-428
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Segmentacja wątroby w obrazach rezonansu magnetycznego
Liver segmentation in magnetic resonance images
Autorzy:
Paw, D.
Badura, P.
Powiązania:
https://bibliotekanauki.pl/articles/98720.pdf
Data publikacji:
2014
Wydawca:
Politechnika Śląska. Katedra Biomechatroniki
Tematy:
segmentacja
wątroba
rezonans magnetyczny
segmentation
liver
magnetic resonance imaging
Opis:
Celem niniejszej pracy było utworzenie algorytmu służącego do segmentacji wątroby w serii obrazów pochodzących z badania wykorzystującego rezonans magnetyczny. Rozwiązanie zostało zawarte w graficznym interfejsie użytkownika tworząc czytelny program. W algorytmie wykorzystano metodę aktywnego konturu, morfologię matematyczną oraz podobne przekształcenia. Wynikiem jest maska 3D oraz liczba wokseli w niej zawartych. Program umożliwia konfrontację wyników.
As a main aim of this project was made a liver segmentation algorithm from Magnetic Resonance Images. Whole solution was made in graphical user interface to make program simple and intuitive in use. In algorithm were used methods like: active contour (snake), mathematical morphology and similar transformations. As result is 3D mask of liver and sum of the voxels containing the mask. Application includes confrontation results.
Źródło:
Aktualne Problemy Biomechaniki; 2014, 8; 145-150
1898-763X
Pojawia się w:
Aktualne Problemy Biomechaniki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bleeding liver tumor in a patient on anticoagulation therapy – case report
Autorzy:
Migdalski, Łukasz
Kuzdak, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1394244.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
liver tumor
intraabdominal bleeding
hepatocellular carcinoma (HCC)
acenocumarolum
anticoagulant therapy
Opis:
Intraabdominal bleeding is a serious surgical problem, particularly in elderly patients following an anticoagulant therapy. It occurs, that abdominal haemorrhage is the first symptom of hepatocellular carcinoma, mostly in Asians and Africans, occasionally in Europeans. The article's author shows a case of an elderly man, treated by Acenocumarolum, in a haemorrhagic shock. During an operation a bleeding liver tumor was revealed. The surgical team performed an effectual tumor resection and stoped the bleeding.
Źródło:
Polish Journal of Surgery; 2015, 87, 12; 641-643
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Magnetic Resonance Elastography – noninvasive method to assess liver disease
Autorzy:
Ożóg, Łukasz
Aebisher, David
Bober, Zuzanna
Bartusik-Aebisher, Dorota
Guz, Wiesław
Cholewa, Marian
Powiązania:
https://bibliotekanauki.pl/articles/454714.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
fibrosis
liver stiffness
MRE
magnetic resonance imaging
Opis:
Currently, liver disease is widespread and the awareness of these diseases is low. Early symptoms of liver disease do not necessarily indicate problems with this organ and patients are usually informed of their problems when the stage of the disease is already advanced. Invasive biopsies are the clinical diagnostic method most commonly used in the evaluation of liver disease. A biopsy is associated with a high risk of false results and additional complications. Finding new non-invasive imaging methods has led to the discovery of a new method called Magnetic Resonance Elastography (MRE). This technique allows one to evaluate the mechanical properties of tissues and to distinguish between pathological states. Testing using this technique can be performed on a conventional magnetic resonance system by using few additional components and properly prepared software. Studies have shown that there is a strong correlation between MRE-measured liver stiffness and the degree of fibrosis. MRE is also useful in characterizing liver tumors. Studies show that this technique is highly credible in both health volunteers and patients with liver fibrosis. MRE has tremendous diagnostic potential. The described technique is not currently widely used and has the 127-132potential to serve as a safe and accurate alternative in clinical diagnostics in the future.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 127-132
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of diet on lipid peroxidation in liver microsomes, intestine brush border membrane and in blood serum of rats
Autorzy:
Tokarz, A.
Oledzka, R.
Sulinski, A.
Powiązania:
https://bibliotekanauki.pl/articles/1371726.pdf
Data publikacji:
1992
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
alpha-tocopherol
beta-carotene
liver microsome
intestine brush border membrane
blood serum
malondialdehyde
natural antioxidant
lipid peroxidation
rat
peroxidation process
diet
fat
liver
microsome
Źródło:
Polish Journal of Food and Nutrition Sciences; 1992, 01, 1
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of ultrasonography in the liver echinococcosis diagnostics
Autorzy:
Owczarczyk-Skoczynska, M.
Grzeszczuk, A.
Olenski, J.
Powiązania:
https://bibliotekanauki.pl/articles/838847.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
hydatid cyst
serological test
Polska
echinococcosis
cystic hydatid disease
liver
ultrasonography
diagnostics
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state - case report
Autorzy:
Kuczynska, M.
Dziaduch, E.
Grzywa-Celinska, A.
Lachowska-Kotowska, P.
Mosiewicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/3662.pdf
Data publikacji:
2014
Wydawca:
Instytut Medycyny Wsi
Tematy:
acute liver failure
liver function
female patient
hepatic cirrhosis
T cell
lymphoma cell
remission state
Źródło:
Journal of Pre-Clinical and Clinical Research; 2014, 08, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prediction of Survival in Patients with Unresectable Colorectal Liver Metastases
Autorzy:
Hołówko, Wacław
Grąt, Michał
Hinderer, Barbara
Orlińska, Izabela
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1395796.pdf
Data publikacji:
2014-07-01
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer
liver metastases
unresectable metastases
survival prediction
Opis:
Liver metastases are diagnosed synchronously with the primary tumour in 25% of patients with colorectal cancer. A half of the remaining patients develop liver metastases within 3 years following colectomy. At present, the only radical treatment of metastases is liver resection. Only 2.6% of patients survive 3 years if such treatment is not implemented. The aim of the study was to assess predictive factors of long-term survival in the group of patients with unresectable colorectal liver metastases carcinoma. Material and methods. Of 1029 patients with colorectal liver metastases, who were treated in the Department of General, Transplant and Liver Surgery of the Medical University of Warsaw in the years 2006-2012, cases of liver metastases assessed intraoperatively as unresectable were selected. The retrospective analysis included 85 patients. Based on the medical documentation, information concerning age, sex, characteristics of primary and secondary tumours, reasons for unresectability, neoadjuvant chemotherapy as well as local treatment of liver tumours was collected. Preoperative serum concentrations of CEA and CA 19-9 markers were considered. The Cox regression model, Kaplan- Meier estimator and log-rank test were applied in the statistical analyses. Results. The most common reason for unresectability were: number of metastases in 31 patients (36.5%) and extrahepatic metastases in 19 cases (22.4%). Overall survival in the entire group was 56.1% and 15.5% after 1 and 3 years respectively. A single-factor analysis showed that CEA serum levels (p=0.032; HR=1.002 per increase by 1 ng/ml) and the presence of extrahepatic metastases (p=0.037; HR=2.06) were predictors of worse survival. In a multivariate analysis, CEA concentration (p=0.017; HR=1.002 per increase by 1 ng/ml) was an independent predictor of death whereas the presence of extrahepatic metastases were not statistically significant (p=0.059; HR=2.09). Conclusions. Serum concentration of CEA marker is an independent predictor of worse survival, but the presence of extrahepatic metastases shows a similar tendency
Źródło:
Polish Journal of Surgery; 2014, 86, 7; 319-324
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Paraoxonase 1 and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis
Autorzy:
Suszyńska-Zajczyk, Joanna
Jakubowski, Hieronim
Powiązania:
https://bibliotekanauki.pl/articles/1039222.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Pon1
high-methionine diet
hyperhomocysteinemia
mouse liver proteome
Opis:
Homocysteine (Hcy), a product of methionine metabolism, is elevated by the consumption of a high-methionine diet that can cause fatty liver disease. Paraoxonase 1 (Pon1), a hydrolase expressed mainly in the liver and carried in the circulation on high-density lipoprotein, participates in Hcy metabolism. Low Pon1 activity is linked to fatty liver disease. We hypothesize that hyperhomocysteinemia and low Pon1 induce changes in gene expression that could impair liver homeostasis. To test this hypothesis, we analyzed the liver proteome of Pon1-/- and Pon1+/+ mice fed a high methionine diet (1% methionine in the drinking water) for 8 weeks using 2D IEF/SDS-PAGE gel electrophoresis and MALDI-TOF mass spectrometry. We identified seven liver proteins whose expression was significantly altered in Pon1-/- mice. In animals fed with a control diet, the expression of three liver proteins involved in lipoprotein metabolism (ApoE), iron metabolism (Ftl), and regulation of nitric oxide generation (Ddah1) was up-regulated by the Pon1-/- genotype. In mice fed with a high-methionine diet, expression of four liver proteins was up-regulated and of three proteins was down-regulated by the Pon1-/- genotype. The up-regulated proteins are involved in lipoprotein metabolism (ApoE), energy metabolism (Atp5h), oxidative stress response (Prdx2), and nitric oxide regulation (Ddah1). The down-regulated proteins are involved in energy metabolism (Gamt), iron metabolism (Ftl), and catechol metabolism (Comt). Expression of one protein (Ftl) was up-regulated both by the Pon1-/- genotype and a high-methionine diet. Our findings suggest that Pon1 interacts with diverse cellular processes - from lipoprotein metabolism, nitric oxide regulation, and energy metabolism to iron transport and antioxidant defenses - that are essential for normal liver homeostasis and modulation of these interactions by a high-methionine diet may contribute to fatty liver disease.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 815-823
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zmiany w wątrobie w przebiegu ciąży
Changes in the liver during pregnancy
Autorzy:
Pedrycz, A.
Zając, A.
Ciechan, A.
Lonc, G.
Zając, G.
Siermontowski, P.
Orłowski, M.
Powiązania:
https://bibliotekanauki.pl/articles/1360588.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
Tematy:
ciąża
wątroba
fizjopatologia
pregnancy
liver
patophysiology
Opis:
Wątroba jest największym, nieparzystym narządem jamy brzusznej i jednocześnie największym gruczołem ludzkiego organizmu. Ciąża jest stanem, który wprowadza w organizmie matki wiele zmian adaptacyjnych, umożliwiających prawidłowy rozwój płodu. Celem niniejszej pracy było zebranie i przedstawianie, na podstawie dostępnej literatury informacji na temat wątroby matki, podczas fizjologicznej ciąży. Wymiary i budowa histologiczna wątroby w czasie ciąży nie ulegają zmianie, natomiast ciąża może wywoływać zmiany obserwowane w schorzeniach wątroby. Ciąża może wpływać na produkcję i wydalanie kwasów żółciowych, a z uwagi na wysoki poziom estrogenów, może dochodzić do niewielkiego zastoju żółci. W czasie ciąży wzrasta także poziom białek produkowanych przez wątrobę.
The liver is the largest unpaired organ in the abdominal cavity and at the same time the largest gland in the human body. Pregnancy is a condition related with the implementation of numerous adaptive changes in the mother's organism which enable proper development of the foetus. The objective of the study was to collect and present on the basis of available literature, information on changes in the mother's liver in the course of physiological pregnancy. The liver's dimensions and histological structure remain unchanged during pregnancy, yet pregnancy may induce changes similar to those observed in various liver conditions. Pregnancy may influence the production and extraction of bile acids, and, due to high oestrogen levels, lead to mild cholestasis. Also, during the course of pregnancy, there is an observable increase in the level of proteins produced by the liver.
Źródło:
Polish Hyperbaric Research; 2014, 3(48); 81-92
1734-7009
2084-0535
Pojawia się w:
Polish Hyperbaric Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Visualization of pathologic changes in liver tissue via polarized light
Autorzy:
Stoilova, Ani
Blagoeva, Blaga
Nazarova, Dimana
Stoykova, Elena
Berberova-Buhova, Nataliya
Nedelchev, Lian
Machikhin, Alexander
Powiązania:
https://bibliotekanauki.pl/articles/2172829.pdf
Data publikacji:
2022
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
polarized light imaging
tissue polarimetry
liver tissue
Opis:
In this work, we applied two polarized light based approaches to visualize histological patterns of liver pathologies. The first one involves acquisition of two images through a polarizing microscope, one image (Ppar) acquired with the analyzer oriented parallel to the polarization of illumination and the other (Pper) acquired with the analyzer oriented perpendicular to the illumination. The final image is based on the polarization ratio, Preconstructed = (Ppar – Pper)/(Ppar + Pper). Using the second technique, the histological specimens were illuminated with a polarized laser beam with wavelength of 635 nm. Polarimetric parameters as azimuth, angle of ellipticity, degree of polarization and reflected power have been measured to quantify the change in the polarization state of the incident light after interaction with the sample of the healthy tissue and of the tissue with abnormal morphological changes.
Źródło:
Optica Applicata; 2022, 52, 3; 395--404
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum activities of liver enzymes in workers exposed to sub-TLV levels of dimethylformamide
Autorzy:
He, Jinjiang
Liu, Jie
Kong, Yulin
Yang, Weiwei
Zhang, Zengli
Powiązania:
https://bibliotekanauki.pl/articles/2177403.pdf
Data publikacji:
2015-03-27
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
dimethylformamide
workers
liver enzymes
TWA
sub-TLV
urine
Opis:
Objectives The aim of this study has been to investigate serum activities of liver enzymes in workers exposed to sub-TLV levels of dimethylformamide (DMF). Material and Methods Seventy-two workers and 72 healthy controls participated in the study. All subjects underwent complete physical examinations and abdominal ultrasound examination. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and c-glutamyl transpeptidase (c-GT) were determined by an auto-chemistry analyzer. The data of airborne concentrations of DMF was obtained from the local Center of Disease Control and Prevention. The level of urine N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC) was measured by means of high-performance liquid chromatography. Results Time weighted average (TWA) concentration of the DMF in workplace was 18.6 (range: 9.8–36.2) mg/m³. The concentration of the AMCC in workers’ urine was 28.32 (range: 1.8–58.6) mg/l and 9 workers’ AMCC exceeded the biological exposure index (40 mg/l). Thirty-one workers reported gastrointestinal symptoms (abdominal pain, nausea, anorexia) and 10 workers reported headache, dizziness and/or palpitation in the exposed group. Serum analysis revealed that both the mean of serum activities of liver enzymes (ALT, AST and c-GT) and the percentage of workers with abnormal liver function were significantly higher in the exposed group as compared to the controls. Conclusions Dimethylformamide can cause liver damage even if air concentration is in the sub-threshold limit value (sub-TLV) level. The protection of skin contact against the exposure to the DMF might be a critical issue as far as the occupational health is concerned.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2015, 28, 2; 395-398
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Machine learning models for predicting patients survival after liver transplantation
Autorzy:
Jarmulski, W.
Wieczorkowska, A.
Trzaska, M.
Ciszek, M.
Paczek, L.
Powiązania:
https://bibliotekanauki.pl/articles/305726.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
machine learning
models interpretability
survival prediction
generalized additive models (GAM)
liver transplant
Opis:
In our work, we have built models predicting whether a patient will lose an organ after a liver transplant within a specified time horizon. We have used the observations of bilirubin and creatinine in the whole first year after the transplantation to derive predictors, capturing not only their static value but also their variability. Our models indeed have a predictive power that proves the value of incorporating variability of biochemical measurements, and it is the first contribution of our paper. As the second contribution we have identified that full-complexity models such as random forests and gradient boosting lack sufficient interpretability despite having the best predictive power, which is important in medicine. We have found that generalized additive models (GAM) provide the desired interpretability, and their predictive power is closer to the predictions of full-complexity models than to the predictions of simple linear models.
Źródło:
Computer Science; 2018, 19 (2); 223-239
1508-2806
2300-7036
Pojawia się w:
Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polscy pionierzy chirurgii wątroby. Nowe odkrycia
Polish pioneers of liver surgery. New discoveries
Autorzy:
Zamachowska, Monika
Powiązania:
https://bibliotekanauki.pl/articles/2085470.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Historii Filozofii i Medycyny
Tematy:
Historia chirurgii wątroby, Julian Pęski,
szew Pęski- Kuzniecow, Rewoliński, Hipolit Oderfeldt,
Roman Jasiński, Jakób Rosenthal, polscy pionierzy
chirurgii wątroby, pionierska operacja nowotworu
wątroby, Szpital Starozakonnych w Warszawie
History of liver surgery, Julian Pensky, Pensky-
Kuznetsoff suture, Rewolinski, Hipolit Oderfeldt,
Roman Jasiński, Jakób Rosenthal, polish pioneers of
liver surgery, pioneers operation of liver tumor, Jewish
Hospital in Warsaw
Opis:
Temat polskich pionierów chirurgii wątroby był już analizowany przez historyków medycyny. Wśród nazwisk polskich lekarzy zdecydowanie najczęściej pojawia się Julian Pęski, ze względu na zastosowaną przez niego nową technikę szycia, która zrewolucjonizowała zabiegi operacyjne w zakresie tego narządu. Szew Pęski-Kuzniecow (Pensky-Kuznetsoff) jest do tej pory stosowany we współczesnej chirurgii. Wspomina się też nazwisko Rewolińskiego, który w 1895 r. zaopatrzył pourazowe uszkodzenie wątroby. Nieznane są zasługi innych XIX wiecznych lekarzy: Hipolita Oderfelda, Romana Jasińskiego i Jakóba Rosenthala. Celem artykułu jest przedstawienie nieznanych polskich pionierów chirurgii wątroby, w szczególności Jakóba Rosenthala, chirurga, który jako pierwszy w Polsce i jeden z pierwszych w Europie wykonał resekcję guza nowotworowego wątroby.
The subject of Polish pioneers of liver surgery has already been analyzed by historians of medicine. Among the names of Polish doctors, Julian Pęski is definitely the most frequent one, due to the use of a new suturing technique that has revolutionized surgical procedures in this organ. Pęski-Kuznetsoff (Pensky-Kuznetsoff) suture is still used in modern surgery. The name of Rewoliński, who in 1895 treated post-traumatic liver damage, is also mentioned. The merits of other nineteenth- century doctors are unknown: Hipolit Oderfeld, Roman Jasiński and Jakób Rosenthal. The aim of the article is to present unknown Polish pioneers of liver surgery, in particular Jakób Rosenthal, a surgeon who was the first in Poland and one of the first in Europe to perform a liver tumor resection.
Źródło:
Archiwum Historii i Filozofii Medycyny; 2021, 84; 93-97
0860-1844
Pojawia się w:
Archiwum Historii i Filozofii Medycyny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Herbal medicine for treatment and prevention of liver diseases
Autorzy:
Rajaratnam, M.
Prystupa, A.
Lachowska-Kotowska, P.
Zaluska, W.
Filip, R.
Powiązania:
https://bibliotekanauki.pl/articles/3402.pdf
Data publikacji:
2014
Wydawca:
Instytut Medycyny Wsi
Tematy:
human disease
herbal medicine
treatment
prevention
liver disease
medicinal plant
hepatoprotective herb
herb
Opis:
The rising number of patients with liver dysfunction due to overwhelming usage of drugs and alcohol has paved the path for researchers in an interest in herbal medicine. This is because there are only a few universally effective and available options for the treatment of common liver diseases, such as cirrhosis, fatty liver and chronic hepatitis. Herbal treatment has been used to alleviate disorders related to liver and other internal organs for many centuries in the eastern world, and have currently become a favourable therapy internationally for pathological liver conditions. In recent years, researchers have used scientific methods to evaluate the effects of plants for the treatment of liver ailments, although in many cases the mechanisms and modes of action of these plants, as well as their therapeutic effectiveness, have not been confirmed. Several hundred plants have been examined to-date, but only a handful has been studied thoroughly. Among these, the current study discusses a compilation of herbal medicines used for liver protection, such as Silymarin (milk thistle), Liv-52, Camellia sinensis (green tea), Glycyrrhizaglabra (licorice) and FuzhengHuayu. The increasing use of herbal medicines reflects their perceived effectiveness in the treatment and prevention of disease, and the belief that these treatments are safe because they are ‘natural’. The presented study evaluates the effects of herbal extracts in the treatment of liver diseases, provides a general understanding of the actions of herbal medicines, a background for understanding the hepatoprotectiveness of herbs, and the challenges that are faced by the scientific community in researching thoroughly of each and every compounds of the herbs.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reoperations for intraabdominal bleeding following deceased donor liver transplantatio
Autorzy:
Figiel, Wojciech
Grąt, Michał
Wronka, Karolina
Patkowski, Waldemar
Krasnodębski, Maciej
Masior, Łukasz
Stypułkowski, Jan
Grąt, Karolina
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1393849.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
liver transplantation
bleeding
reoperation
mortality
outcomes
Opis:
Intraabdominal hemorrhage remains one of the most frequent surgical complications after liver transplantation. The aim of the study was to evaluate risk factors for intraabdominal bleeding requiring reoperation and to assess the relevance of the reoperations with respect to short- and long-term outcomes following liver transplantation. Material and methods. Data of 603 liver transplantations performed in the Department of General, Transplant and Liver Surgery in the period between January 2011 and September 2014 were analyzed retrospectively. Study end-points comprised: reoperation due to bleeding and death during the first 90 postoperative days and between 90 postoperative day and third post-transplant year. Results. Reoperations for intraabdominal bleeding were performed after 45 out of 603 (7.5%) transplantations. Low pre-transplant hemoglobin was the only independent predictor of reoperation (p=0.002) with the cut-off of 11.3 g/dl. Postoperative 90-day mortality was significantly higher in patients undergoing reoperation as compared to the remaining patients (15.6% vs 5.6%, p=0.008). Post-transplant survival from 90 days to 3 years was non-significantly lower in patients after reoperation for bleeding (83.3%) as compared to the remaining patients (92.2%, p=0.096). Nevertheless, multivariable analyses did not reveal any significant negative impact of reoperations for bleeding on short-term mortality (p=0.589) and 3-year survival (p=0.079). Conclusions. Surgical interventions due to postoperative intraabdominal hemorrhage do not appear to affect short- and long-term outcomes following liver transplantation. Preoperative hemoglobin concentration over 11.3 g/dl is associated with decreased risk of this complication, yet the clinical relevance of this phenomenon is doubtful.
Źródło:
Polish Journal of Surgery; 2016, 88, 4; 196-201
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impaired base excision repair is related to the pathogenesis of non-alcoholic fatty liver disease
Autorzy:
Ziółkowska, Sylwia
Czarny, Piotr
Szemraj, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1024273.pdf
Data publikacji:
2020-12-30
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
DNA repair
non-alcoholic fatty liver
base excision repair
Opis:
Non-alcoholic fatty disease (NAFLD) is a liver disorder that affects up to 30% of the population, mainly in Western countries. It is estimated that up to 75% of NAFLD patients will develop a more aggressive form of the disease, non-alcoholic steatohepatitis (NASH). NAFLD can lead to fibrosis and liver failure; however, it is difficult to diagnose NAFLD due to its non-specific symptoms. Unfortunately, there is no treatment available for this disease. The risk factors of NAFLD are obesity and insulin resistance (IR). The molecular factors that seem to play an important role in the pathogenesis of NAFLD are oxidative stress as well as impaired DNA damage repair processes; a great body of evidence confirms an association with the base excision repair (BER) pathway. The activity of BER is decreased in patients with NAFLD and in animal models of this disease. In order to better understand the underlying basis of the disease, knowledge should be broadened in the area of DNA repair in NAFLD.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2020, 16; 5-11
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Czynniki ryzyka włóknienia wątroby u osób zakażonych hcv - doniesienia wstępne
The risk factors of the liver fibrosis in patients infected by hcv
Autorzy:
Dzieńdziora-Frelich, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/526619.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Opolski. Instytut Nauk o Zdrowiu
Tematy:
wątroba
hcv
włóknienie
liver
fibrosis
Opis:
Wstęp: HCV stanowi poważny problem w praktyce medycznej. Większość powikłań w przebiegu chorób wątroby jest konsekwencją zaawansowanego włóknienia prowadzącego nawet do marskości wątroby. Cel pracy: Celem niniejszych badań jest analiza wybranych czynników ryzyka rozwoju włóknienia wątroby u osób z zakażeniem hcv. Materiał i metody: Materiał badawczy stanowiła grupa pacjentów mieszkających na terenie województwa śląskiego. Badaną grupę stanowiły 102 osoby w wieku 13-70 lat. chorzy diagnozowani byli na oddziałach chorób zakaźnych i chorób wewnętrznych z podejrzeniem hcv. Ostateczne rozpoznanie ustalono na podstawie wywiadu z pacjentami oraz oceny histopatologicznej biopsji wątroby. Wyniki: W niniejszych badaniach udział wzięło 66 mężczyzn i 36 kobiet. Przedział wiekowy 13-23 lat stanowi 7,8%, 13, 7% to populacja w wieku 24-34 lat, 32, 4% to badani w wieku 35-45 lat, 27, 5% - pacjenci w przedziale wiekowym 46-56 lat, 16, 7% to populacja w wieku 57-67 lat, 1,9% badanych stanowiła grupa powyżej 67 roku życia. nadwaga występowała u 55,9% badanych, 76, 5% populacji to osoby palące. Wnioski: Na podstawie analizy badań stwierdza się, że wirus hcv z postępującym włóknieniem najczęściej występuje w przedziale wiekowym 35-45 lat, częściej wśród mężczyzn niż wśród kobiet. większość badanych to osoby palące papierosy oraz osoby z nadwagą.
Introduction: Hcv constitutes a serious problem in medical practice. Most complications in the course of the disease derive from advanced fibrosis leading even to the liver cirrhosis. Aim of the research: The aim of the research is the analysis of some selected risk factors of the development of fibrosis in patients with hcv and the frequency of the virus infections in The Silesia Region. Material and methods: The material was collected from the patients living in The Region of Silesia. The population for the research consisted of 102 patients at the age of 13 – 70. The patients were diagnosed as sufering from hcv by The Infectious and Internal Diseases Departments. The final diagnosis was made after interviewing the patients and the examinations of histopathological liver biopsy. The results: There were 66 males and 36 females participating in the research. Patients aged 13-23 ( 13) constituted 7,8 per cent, 24-34 (32) 7 per cent, 35-45 (27) 4 per cent, 46-56 (16) 5 per cent, 57-67 7 per cent and 2 per cent of patients over 67. 55,9 per cent of the patients were overweight and 76,5 per cent smokers. Conclusions: Taking into account the research analysis, it might be concluded that the hcv virus accompanied by liver fibrosis is found most often in the group of patients aged 35-45 and more often in males than in females. Most research patients are overweight and smoke cigarettes.
Źródło:
Puls Uczelni; 2013, 1; 7-9
2080-2021
Pojawia się w:
Puls Uczelni
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histochemical study on oxidative and antioxidative enzymes of mouse liver in the course of infection with Babesia microti
Autorzy:
Kuzna-Grygiel, W.
Kolodziejczyk, L.
Powiązania:
https://bibliotekanauki.pl/articles/838274.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
oxidative enzyme
infection
mouse
Babesia microti
mice
liver
antioxidative enzyme
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally
Autorzy:
Kiełczykowska, Małgorzata
Kopciał, Ewelina
Marzec, Zbigniew
Musik, Irena
Powiązania:
https://bibliotekanauki.pl/articles/972530.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
lithium
selenium
iron
manganese
copper
zinc
male rats
liver
Opis:
Introduction and objective. Lithium and selenium have been the subjects of extensive research for many years. Concern about the physiological action of these elements results from the application of lithium in medicine, as well as the beneficial influence of selenium supplementation in different pathological states. However, little data are available concerning their effect on the homeostasis of essential microelements in organs. Therefore, the aim of the current study was to evaluate the influence of lithium and/or selenium administration on homeostasis of iron, zinc, copper and manganese in the liver of rats. Materials and method. The experiment was carried on 24 male Wistar rats (4 groups of 6 animals) subjected to the treatment with: group I (control) – saline; group II – lithium carbonate at a dose of 2.7 mg Li/kg b.w.; group III – sodium selenite at a dose of 0.5 mg Se/kg b.w.; group IV – both lithium carbonate and sodium selenite at the doses mentioned above. Administration was performed for 6 weeks, once a day by stomach tube, in the form of water solutions. Results. The tissue content of zinc, iron and manganese showed no statistical differences among the studied groups. Zn was slightly decreased in group III vs. control and group II. Fe was insignificantly enhanced in groups II and IV vs. control. Mn in group IV was slightly increased vs. groups II and III. Cu in group III was significantly decreased vs. group IV and slightly depleted vs. groups I and II. Conclusion. With the exception of Cu in the Se-treated group, lithium and/or selenium did not affect the studied microelements’ liver homeostasis in a significant way. These results may contribute to the knowledge of essential microelements homeostasis in human organisms undergoing lithium therapy, and/or selenium supplementation.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 132-135
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mucormycosis in a patient with acute myeloblastic leukemia following liver transplantation for Wilson’s disease
Autorzy:
Łanocha, A.A.
Guzicka-Kazimierczak, R.
Zdziarska, B.
Wawrzynowicz-Syczewska, M.
Powiązania:
https://bibliotekanauki.pl/articles/2085182.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
Mucormycosis
acute myeloblastic leukemia
Willson’s disease
liver transplantation
Opis:
A case is presented of mucormycosis in a patient with acute myeloblastic leukemia following liver transplantation for Wilson’s disease. A 58-year-old female was admitted to the Department of Haematology with deterioration of her general condition, loss of appetite, tiredness and difficulty with mental contact for a few days. Blood and urine cultures for bacteria and fungus, galactomannan antigen were negative. Whole body computed tomography demonstrated bilateral hilar lymphadenopathy with necrotic lesions: splenomegaly with a hypodensive lesion 13 × 20 × 19 mm and lower pulmonary infiltrates suggested fungal etiology. Magnetic resonance imaging of the brain showed thickened meninges. Finally, mucormycosis was diagnosed. Treatment with amphotericin B lipid complex was started, resulting in an partial improvement of the general condition and decreased level of inflammatory markers. However, the patient’s condition continued to deteriorate, with sepsis etiology Escherichia coli, and despite the intensive managements she eventually died.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 4; 665-668
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Severe gynaecomastia associated with spironolactone treatment in a patient with decompensated alcoholic liver cirrhosis - case report
Autorzy:
Schab, K.
Prystupa, A.
Mulawka, D.
Mulawka, P.
Powiązania:
https://bibliotekanauki.pl/articles/3042.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
gynaecomastia
spironolactone
treatment
patient
alcoholic disease
liver cirrhosis
Opis:
Gynaecomastia is uni- or bilateral breast enlargement in males associated with benign hyperplasia of the glandular, fibrous and adipose tissue resulting from oestrogen-androgen imbalance. Asymptomatic gynaecomastia is a common finding in healthy male adults and does not have to be treated, while symptomatic gynaecomastia might be the symptoma of many pathological conditions and requires meticulous diagnosis and therapeutic management. The commonest causes of gynaecomastia in the Polish population include liver cirrhosis and drugs used to treat its complications. The current study presents the case of severe painless gynaecomastia in a patient with decompensated alcoholic liver cirrhosis, treated with spironolactone because of ascites. Breast enlargement assessed a IIb according to the Simon’s Scale or III according to the Cordova-Moschella classification, developed slowly over the two-year period of low-dose spironolactone therapy The course and dynamics of disease are described and the main mechanisms leading to its development discussed. The importance of effective treatment of patients with severe gynecomastia is emphasized as the disease may result in significant psychosocial problems.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ultrasound imaging of the liver and bile ducts – expectations of a clinician
Badanie ultrasonograficzne wątroby i dróg żółciowych – oczekiwania klinicysty
Autorzy:
Skoczylas, Krzysztof
Pawełas, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1053137.pdf
Data publikacji:
2015
Wydawca:
Medical Communications
Tematy:
CEUS
bile ducts
elastography
fatty liver
ceus
drogi żółciowe
elastografia
stłuszczenie wątroby
Opis:
Since diseases of the liver and bile ducts are common, a clinician is faced by the need to implement an appropriate diagnostic process. It is necessary to apply diagnostic methods that enable appropriate assessment of the most common pathologies of the liver, i.e. fibrosis, steatosis and focal lesions, as well as initial assessment of the bile ducts. These goals can be achieved using ultrasound methods based on conventional sonography, contrast-enhanced sonography and elastography. The assessment of fatty liver and bile duct dilatation using ultrasound reaches satisfactory levels of sensitivity and specificity. The usage of contrast agents enables unambiguous differentiation between benign and malignant focal lesions, frequently allowing them to be identified accurately without the assistance of other imaging modalities. Elastography has enabled reliable assessment of liver fibrosis. Its results are comparable to those of the standard method, i.e. liver biopsy.
W związku z powszechnym występowaniem chorób wątroby i dróg żółciowych klinicysta stoi przed problemem wdrożenia odpowiedniej diagnostyki. Istnieje potrzeba stosowania metod diagnostycznych umożliwiających odpowiednią ocenę najczęstszych patologii wątroby, to jest włóknienia, stłuszczenia miąższu wątroby, różnicowania zmian ogniskowych, czy wstępną ocenę patologii dróg żółciowych. Na osiągnięcie tych celów pozwala zastosowanie metod ultrasonograficznych opartych na klasycznej ultrasonografii, ultrasonografii z wykorzystaniem kontrastów dożylnych i elastografii. Ultrasonograficzna ocena stłuszczenia wątroby i poszerzenia dróg żółciowych osiąga zadowalającą czułość i specyficzność. Zastosowanie kontrastów dożylnych pozwala na jednoznaczne różnicowanie między łagodnymi a złośliwymi zmianami ogniskowymi, często umożliwiając prawidłową ich identyfikację bez konieczności stosowania innych metod badań obrazowych. Zastosowanie metody elastografii umożliwiło wiarygodną ocenę włóknienia wątroby, z wynikami porównywalnymi do standardowej metody, jaką jest biopsja wątroby.
Źródło:
Journal of Ultrasonography; 2015, 15, 62; 292-306
2451-070X
Pojawia się w:
Journal of Ultrasonography
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases.
Autorzy:
Czuczejko, Jolanta
Zachara, Bronisław
Staubach-Topczewska, Ewa
Halota, Waldemar
Kędziora, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1043405.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
selenium
glutathione peroxidase
chronic liver disease
glutathione
oxidative stress
Opis:
Disturbances in the antioxidant system could play a role in pathogenesis of chronic liver disease. The aim of our study was to evaluate the levels/activities of antioxidants in blood of patients with chronic liver disease. We estimated selenium and glutathione concentrations and glutathione peroxidase activities in blood of 59 patients with chronic hepatitis B or C virus infection (group 1) and 64 patients with alcoholic, autoimmune or cryptogenic chronic liver disease (group 2). The results were compared with 50 healthy controls. Whole blood and plasma selenium and red cell glutathione concentrations were significantly lower in the patients compared with the controls. Red cell glutathione peroxidase activity was slightly reduced in both subgroups of group 1 and in group 2 with normal alanine aminotransferase values. Plasma glutathione peroxidase activity was slightly but significantly higher in patients with elevated aminotransferase values. The findings suggest that disturbances in antioxidant parameters in blood of patients with chronic liver disease may be the cause of the peroxidative damage of cells.
Źródło:
Acta Biochimica Polonica; 2003, 50, 4; 1147-1154
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Premature mortality due to alcohol-related diseases of the liver in Poland according to voivodships
Autorzy:
Paciej, Paulina
Ciabiada, Beata
Maniecka-Bryła, Irena
Powiązania:
https://bibliotekanauki.pl/articles/552721.pdf
Data publikacji:
2017
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
premature mortality
years of life lost
alcohol
iseases of the liver.
Źródło:
Family Medicine & Primary Care Review; 2017, 3; 251-255
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Management of Giant Hepatic Hemangioma in Atypical Localization; Report of a Case and Literature Review
Autorzy:
Stankiewicz, Rafał
Kobryń, Konrad
Patkowski, Waldemar
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1395563.pdf
Data publikacji:
2015-03-01
Wydawca:
Index Copernicus International
Tematy:
giant hemangioma
liver benign neoplasm
cholecystectomy
tumor enucleation
liver surgery
Opis:
Hemangiomas are the most common benign primary hepatic neoplasms, often being incidentally discovered. In most of the cases they are small and asymptomatic. It is widely accepted that clinical intervention is indicated only for symptomatic hemangiomas. We present a case of an asymptomatic giant hemangioma managed by enucleation due to its atypical localization. The hemangioma, originally located in segment 5, was now described in Computer Tomography (CT) Imaging as separating the gallbladder from the liver parenchyma. A careful evaluation of images revealed proximity to the portal vein (PV), right hepatic artery (RHA), right hepatic duct (RHD) and right branch of the portal vein (RBPV). Thus, in the case of an emergent operation, surgical maneuvers in the area of the altered hepatic anatomy and proximity to the hemangioma itself, would in fact increase the risk endangering the patient’s life. After patient’s consent, a surgical enucleation en block with the gall-bladder was performed. It is of great importance that specifically selected, asymptomatic patients diagnosed with a giant hemangioma, with the above mentioned or similar localization should be considered for surgical treatment.
Źródło:
Polish Journal of Surgery; 2015, 87, 3; 139-142
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pathogenesis and clinical consequences of iron overload in chronic hepatitis C - impact of host and viral factors related to iron metabolism
Autorzy:
Sikorska, K.
Romanowski, T.
Bielawski, K.P.
Powiązania:
https://bibliotekanauki.pl/articles/80838.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
antiviral therapy
chronic hepatitis C
clinical consequence
fibrosis
hepatocellular carcinoma
infection
interferon
iron metabolism
iron overload
liver cirrhosis
liver disease
liver transplantation
pathogenesis
ribavirin
virus replication
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of bariatric surgery on non-alcoholic fatty liver disease
Autorzy:
Major, Piotr
Pędziwiatr, Michał
Rubinkiewicz, Mateusz
Stanek, Maciej
Głuszewska, Anna
Pisarska, Magdalena
Małczak, Piotr
Budzyński, Andrzej
Budzyński, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1393188.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
non-alcoholic fatty liver disease
bariatric surgery
morbid obesity
Opis:
Introduction; p to 300 million people have the body mass index (BMI) greater than 30 kg/m2. Obesity is the cause of many serious diseases, such as type 2 diabetes, hypertension, and non-alcoholic fatty liver disease (NAFLD). Bariatric surgery is the only effective method of achieving weight loss in patients with morbid obesity. Objectives: The aim of the study was to assess the impact of bariatric surgery on non-alcoholic fatty liver disease in patients operated on due to morbid obesity. Material and Methods: We included 20 patients who were qualified for bariatric procedures based on BMI > 40 kg/ m2 or BMI > 35kg/m2 with the presence of comorbidities. The average body weight in the group was 143.85kg, with an average BMI of 49.16kg/m2. Before the procedure, we evaluated the severity of non-alcoholic fatty liver disease in each patient using the Sheriff-Saadeh ultrasound scale. We also evaluated the levels of liver enzymes. Follow-up evaluation was performed twelve months after surgery. Results: Twelve months after surgery, the average weight was 102.34 kg. The mean %WL was 33.01%, %EWL was 58.8%, and %EBMIL was 61.37%. All patients showed remission of fatty liver disease. Liver damage, evaluated with ultrasound imaging, decreased from an average of 1.85 on the Sheriff-Saadeh scale, before surgery, to 0.15 twelve months after surgery (p < 0.001). As regards liver enzymes, the level of alanine aminotransferase decreased from 64.5 (U/l) to 27.95 (U/l) (p < 0.001), and the level of aspartate aminotransferase decreased from 54.4 (U/l) to 27.2 (U/l). Conclusions: Bariatric procedures not only lead to a significant and lasting weight loss, but they also contribute to the reduction of fatty liver disease and improve liver function.
Źródło:
Polish Journal of Surgery; 2017, 89, 2; 1-4
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma
Autorzy:
Czeczot, Hanna
Ścibior, Dorota
Skrzycki, Michał
Podsiad, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1041298.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
malondialdehyde
glutathione S-transferase
glutathione reductase
liver cirrhosis
glutathione peroxidase
glutathione
hepatocellular carcinoma
Opis:
We investigated glutathione level, activities of selenium independent GSH peroxidase, selenium dependent GSH peroxidase, GSH S-transferase, GSH reductase and the rate of lipid peroxidation expressed as the level of malondialdehyde in liver tissues obtained from patients diagnosed with cirrhosis or hepatocellular carcinoma. GSH level was found to be lower in malignant tissues compared to adjacent normal tissues and it was higher in cancer than in cirrhotic tissue. Non-Se-GSH-Px activity was lower in cancer tissue compared with adjacent normal liver or cirrhotic tissue, while Se-GSH-Px activity in cancer was found to be similar to its activity in cirrhotic tissue and lower compared to control tissue. An increase in GST activity was observed in cirrhotic tissue compared with cancer tissue, whereas the GST activity in cancer was lower than in adjacent normal tissue. The activity of GSH-R was similar in cirrhotic and cancer tissues, but higher in cancer tissue compared to control liver tissue. An increased level of MDA was found in cancer tissue in comparison with control tissue, besides its level was higher in cancer tissue than in cirrhotic tissue. Our results show that the antioxidant system of cirrhosis and hepatocellular carcinoma is severely impaired. This is associated with changes of glutathione level and activities of GSH-dependent enzymes in liver tissue. GSH and enzymes cooperating with it are important factors in the process of liver diseases development.
Źródło:
Acta Biochimica Polonica; 2006, 53, 1; 237-242
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Septic shock in the course of liver abscess rescued with percutaneous drainage – a literature review and case report
Autorzy:
Snarska, Jadwiga
Michalak, Maciej
Masiulaniec, Piotr
Jacyna, Krzysztof
Zalewski, Artur
Powiązania:
https://bibliotekanauki.pl/articles/1393916.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
liver abscess
septic shock
percutaneous drainage
Opis:
This study presented a septic shock occurring with striking speed during the percutaneous drainage of a large abscess of the liver in an 18-year-old female patient after an appendectomy performed 3 months earlier using the laparoscopic method because of its phlegmonous and gangraenosus inflammation. The post-operative course was complicated by increased suppuration in places after removal of the trocars. After including the intravenous antibiotic therapy and under the USG control, the percutaneous drainage of the abscess was performed. While withdrawing the guide of the drainage catheter set, the symptoms of septic shock occurred. The pharmacological treatment was applied with continuation of the antibiotic therapy till a negative result of microbiological tests was obtained and the normalization of life parameters. The patient was not qualified for treatment in the ICU. She was discharged in a generally good condition after 24 days of hospitalization. In the case of this patient, the drain covered with the content of the abscess may have contact with the adjacent tiny blood vessels, which may have contributed to the systemic inflammatory response syndrome that was linked with fast-developing sceptic shock.
Źródło:
Polish Journal of Surgery; 2016, 88, 5; 496-503
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Can round ligament of the liver patch decrease the rate and the grade of postoperative pancreatic fistula?
Autorzy:
Mech, Katarzyna
Wysocki, Łukasz
Guzel, Tomasz
Słodowski, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1393942.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
pancreatic fistula
round ligament of the liver
pancreatic resections
Opis:
The most serious complication after pancreatic surgical procedures is still a postoperative pancreatic fistula. In clinical practice there are various methods to prevent the formation of pancreatic fistula, but none of them is fully efficient. Recently, the role of grafting the round ligament of the liver on the pancreas is emphasized as a promising procedure which reduces the severity and shortens the healing time of postoperative pancreatic fistula. The aim of the study was to assess the impact of grafting a round ligament patch on the pancreatic stump or the area of the pancreatic anastomosis on the severity and healing of pancreatic fistula after surgical treatment of the pancreas (alternatively on prevention of pancreatic fistula formation). Material and methods. The retrospective study covered patients operated due to pancreatic tumors in the Department of General, Gastrointestinal and Oncologic Surgery of the WUM. Pancreatic fistula was diagnosed according to the definition developed by the ISGPS (International Study Group of Pancreatic Surgery). Results. 10 patients with pancreatic tumors of different location were operated. The round ligament was grafted on the pancreatic stump, the area of the pancreatic anastomosis or on the site of the local tumor removal. Pancreatic fistula developed in 9 patients, including grade A pancreatic fistula in 5 patients, grade B fistula in 3 patients, and grade C fistula in 1 patient. Distant complications occurred in one patient. None of the patients required a reoperation and no deaths were reported. The average hospital stay was 22.4 days. The hospital stay of patients with grade A fistula was shorter than in case of patients with grade B and C fistula. Conclusions. Grafting of the round ligament of the liver on the pancreatic stump did not prevent the development pancreatic fistula. Grade A pancreatic fistula developed most often. Grade C fistula developed in 1 patient and was complicated by intraabdominal abscesses and sepsis. Although the patient did not require a repeated surgery, but only a continuation of conservative treatment on an outpatient basis. Patients with grade B fistula required prolonged drainage and in the end were supervised by the surgical polyclinic.
Źródło:
Polish Journal of Surgery; 2016, 88, 2; 63-67
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Value of Intraoperative Liver Ultrasound Assessment Using an Intraabdominal Probe During Laparotomy Performed for Oncological Reasons
Autorzy:
Kruszewski, Wiesław Janusz
Walczak, Jakub
Szajewski, Mariusz
Buczek, Tomasz
Ciesielski, Maciej
Szefel, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/1396045.pdf
Data publikacji:
2013-02-01
Wydawca:
Index Copernicus International
Tematy:
intraoperative ultrasound
liver surgery
Opis:
The quality of liver assessment in an oncological patient plays an important role in the selection of a proper type of medical intervention. Diagnostic techniques commonly used in liver imaging are still far from perfect. Intraoperative liver evaluation using an intraabdominal ultrasound probe remains an important tool for proper assessment of this organ. The aim of the study was to evaluate suitability of this intraoperative diagnostic method for detection of primary and secondary neoplastic pathologies of the liver. Material and methods. Between March 2010 and the end of December 2011, we performed intraoperative ultrasound examinations of the liver during 220 of 461 laparotomies carried out for oncological reasons. Results. In 72 patients (33%), intraoperative ultrasonography using an intraabdominal probe revealed neoplastic pathologies in the liver. In 16 patients (7%), the pathologies had not been observed in the preoperative imaging examinations. In 7 cases (3%), the detected tumors were impalpable and invisible in macroscopic examination routinely performed during laparotomy. The time of performing preoperative liver examinations did not affect the detection of previously unrecognized liver tumors (p > 0.05). We found progression in the number of liver tumors in 28 patients (39%). In 20 patients (9%), the primary surgical plans were changed intraoperatively. Conclusions. Liver examination using an intraabdominal ultrasound probe is a useful tool for assessment of neoplastic disease progression. The procedure allows proper choice of an optimal treatment regime and decreases the risk of performing an unnecessary oncological invasive procedure.
Źródło:
Polish Journal of Surgery; 2013, 85, 2; 78-82
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on liver function indices of benign prostatic hyperplasia (BPH) induced rats
Autorzy:
Uroko, R.I.
Adamude, F.A.
Egba, S.I.
Chukwu, C.N.
Asadu, C.L.
Okwara, E.C.
Powiązania:
https://bibliotekanauki.pl/articles/2049077.pdf
Data publikacji:
2020
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
Funtumia africana
Abutilon mauritianum
liver marker enzymes
liver function indices
benign prostatic hyperplasia
enzymy wątrobowe
wskaźniki wątrobowe
łagodny przerost gruczołu krokowego
Opis:
Objective: This study evaluated the effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on the liver function indices of benign prostatic hyperplasia (BPH) induced rats. Materials and Methods: The study used 30 rats divided into 5 groups, comprising normal control, BPH control, standard control, and BPH induced rats treated with 200 and 600 mg/kg/day of FAAM respectively. Results: The BPH induction caused significant (p<0.05) increases in aspartate transaminase (AST) and alkaline phosphatase (ALP) activities of the BPH control when compared with the normal control. The BPH control also had significantly (p<0.05) reductions in the total protein, albumin and globulin concentrations and significant (p<0.05) elevated total bilirubin and direct bilirubin concentrations relative to the normal control. The FAAM treated BPH-induced rats had non-significantly (p>0.05) reduced AST, and alanine transaminase (ALT) activities relative to the BPH control. The BPH-induced rats treated with 600 mg/kg/day of FAAM had significantly (p<0.05) reduced ALP activities relative to the BPH control. Treatment with FAAM caused significant (p<0.05) increases in the total protein, albumin, globulin concentrations and significant (p<0.05) reductions in the total bilirubin and direct bilirubin concentrations relative to the BPH control. BPH had no observable adverse effects on the liver histomorphology of the rats. Conclusion: The findings of this study indicated that BPH impairs liver functions and treatment of BPH with combined ethanol extract of F. africana and A. mauritianum leaves restore normal liver functions in rats with BPH.
Źródło:
Herba Polonica; 2020, 66, 3; 24-35
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Is there a rationale for aggressive breast cancer liver metastases resections in Polish female patients? Analysis of overall survival following hepatic resection at a single centre in Poland
Autorzy:
Kobryń, Eliza
Kobryń, Konrad
Wróblewski, Tadeusz
Kobryń, Krzysztof
Pietrzak, Radosław
Rykowski, Paweł
Ziarkiewicz-Wróblewska, Bogna
Lamparski, Krzysztof
Zieniewicz, Krzysztof
Patkowski, Waldemar
Krawczyk, Marek
Paluszkiewicz, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/991146.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Tematy:
liver metastases
breast cancer
liver surgery
Opis:
Introduction. Breast cancer (BC) makes up nearly 26% of malignant tumours worldwide and is the leading cause of cancerrelated deaths in European women. With approximately 18,000 new cases of BC diagnosed in Polish women annually, breast cancer liver metastasis (BCLM) is respectively an increasing issue. Recent data found in literature indicates improved survival following liver resection with systemic therapy. Objective. The aim of study was to evaluate surgical treatment in patients with isolated BCLM. Materials and method. During 2009–2013, a retrospective study was undertaken and 30 cases analysed. From nearly 2,000 liver resections performed, 11 female patients at the mean age of 59.18 years with BCLM were qualified for surgery. Results. The median time between primary and secondary treatment was 3.5 years (1–7). One patient (9.1%) presented an extrahepatic lesion – bone metastasis. The left lobe, right lobe and both lobes of the liver were affected, respectively, in 3 (27.3%), 4 (36.4%) and 4 (36.4%) patients. 5 patients (45.5%) presented single hepatic lesion, in contrast to the maximum number of lesions which equalled 6 in the right lobe. Average hospitalisation period was 13.27 days and discharge on the 11.3 postoperative day. One-year survival was 72.7% (8 patients); therefore, three-year survival was 36.4% (4 patients). Conclusions. Oncological centres should assess BCLM patients more openly and qualify them for hepatic resection along with adjuvant systemic treatment in order to improve overall survival. This, however, needs to be studied in a multicentre randomized trial.
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The 35 kDa acid metallophosphatase of the frog Rana esculenta liver: studies on its cellular localization and protein phosphatase activity.
Autorzy:
Szalewicz, Agata
Strzelczyk, Barbara
Sopel, Mirosław
Kubicz, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/1043638.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metallophosphatase
acid phosphatase
frog liver
protein phosphatase
tyrosine protein phosphatase
Opis:
The cellular localization of the 35 kDa, low molecular mass acid metallophosphatase (LMW AcPase) from the frog (Rana esculenta) liver and its activity towards P-Ser and P-Tyr phosphorylated peptides were studied. This enzyme was localized to the cytoplasm of hepatocytes but did not appear in other cells of liver tissue (endothelium, macrophages, blood cells). This LMW AcPase does not display activity towards 32P-phosphorylase a under conditions standard for the enzymes of PPP family. Proteins containing P-Ser: rabbit 32P-phosphorylase a and phosvitin are hydrolysed only at acidic pH and are poor substrates for this enzyme. The frog AcPase is not inhibited by okadaic acid and F- ions, the Ser/Thr protein phosphatase inhibitors. Moreover, the frog enzyme does not cross-react with specific antisera directed against N-terminal fragment of human PP2A and C-terminal conserved fragment of the eukaryotic PP2A catalytic subunits. These results exclude LMW AcPase from belonging to Ser/Thr protein phosphatases: PP1c or PP2Ac. In addition to P-Tyr, this enzyme hydrolyses efficiently at acidic pH P-Tyr phosphorylated peptides (hirudin and gastrin fragments). Km value for the hirudin fragment (7.55 ± 1.59 × 10-6 M) is 2-3 orders of magnitude lower in comparison with other substrates tested. The enzyme is inhibited competitively by typical inhibitors of protein tyrosine phosphatases (PTPases): sodium orthovanadate, molybdate and tungstate. These results may suggest that the LMW AcPase of frog liver can act as PTPase in vivo. A different cellular localization and different response to inhibition by tetrahedral oxyanions (molybdate, vanadate and tungstate) provide further evidence that LMW AcPase of frog liver is distinct from the mammalian tartrate-resistant acid phosphatases.
Źródło:
Acta Biochimica Polonica; 2003, 50, 2; 555-566
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Simple and non-invasive liver fibrosis stage prediction method
Autorzy:
Orczyk, T.
Pałys, M.
Porwik, P.
Musialik, J.
Błońska-Fajfrowska, B.
Powiązania:
https://bibliotekanauki.pl/articles/333411.pdf
Data publikacji:
2011
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
zwłóknienie wątroby
wirusowe zapalenie wątroby typu C
przewidywanie etapu
liver fibrosis
hepatitis C
stage prediction
Opis:
In this paper a simple and non-expensive indirect fibrosis stage prediction method is described. Presented method is non-invasive and is based on the results of the generic blood tests. The method is based on a statistical analysis of wide range of blood tests results supported with the experience of hepatologists.
Źródło:
Journal of Medical Informatics & Technologies; 2011, 17; 227-231
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of triiodothyronine on the content of phospholipids in the rat liver nuclei
Autorzy:
Bucki, R.
Gorska, M.
Zendzian-Piotrowska, M.
Gorski, J.
Powiązania:
https://bibliotekanauki.pl/articles/69507.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
phosphatidylethanolamine
serum
cardiolipin
triiodothyronine
rat
phosphatidylinositol
phospholipid
saline
sphingomyelin
liver
nucleus
phosphatidylserine
phosphatidylcholine
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of mercury in muscles, liver and gills of marine and freshwater fish
Autorzy:
Luczynska, J.
Luczynski, M.J.
Paszczyk, B.
Powiązania:
https://bibliotekanauki.pl/articles/1189779.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
fish
total mercury
mercury
muscle
liver
gill
marine fish
freshwater fish
body weight
total length
biotic factor
condition factor
Opis:
In this study, the total mercury concentration was determined in the muscles, liver and gills of six fish species (rainbow trout Oncorhynchus mykiss Walb., carp Cyprinus carpio L., bream Abramis brama L., perch Perca fluviatilis L., ide Leuciscus idus L. and flounder Platichthys flesus L.). The fish were acquired from October to November 2012. Mercury was analyzed by atomic absorption spectrometry using thermal decomposition, compounds of mercury and amalgamation. The mercury content in fish organs reached 0.006-0.168 (in mg kgˉ¹ wet weight) in muscles, 0.001-0.027 in gills and 0.003-0.045 in the liver. The muscles of perch and ide had significantly more Hg compared to the other fish’s muscles (P≤0.05). The liver and gills of perch, ide and flounder contained more Hg than the same tissues of the other fish (P≤0.05). Generally, the highest Hg content was determined in muscles (except rainbow trout) (P≤0.05), whereas the lowest Hg content was found in gills (except perch) (P≤0.05). The content of Hg in gills of perch did not differ from the one in the liver (P>0.05). There was a positive correlation between the weight or length of a fish and the Hg concentration in its tissues, except for the length and Hg in the gills of carp. However, a statistically significant positive correlation between the body weight and the Hg levels in fish appeared only in the case of the organs of ide (P≤0.004) and muscles of carp (P≤0.038). The correlation between the factor condition and the content of Hg, albeit positive (0.106 < r < 0.811) except for the organs of flounder, was not statistically significant (P>0.05).
Źródło:
Journal of Elementology; 2016, 21, 1; 113-129
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Long-term survival of a young patient after multi-disciplinary treatment of initially inoperable stomach cancer with metastases to the liver and visceral lymph node
Autorzy:
Zakrzewska, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1064808.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
inoperable stomach cancer
liver metastases
palliative chemotherapy
radical resection
regression of lesions
Opis:
This paper reports on a 5-year survival of a 30-year-old male patient initially diagnosed with inoperable stomach cancer with metastases to the liver and the visceral lymph node. The systemic treatment regimen (8 cycles of DCF chemotherapy) resulted in an almost complete regression and enabled implementation of a radical resection of the stomach along with the spleen. Eight months into the treatment, the disease progressed producing several metastatic lesions to the liver. The patient received second-line palliative chemotherapy (4 cycles of EOX) which led to a significant reduction of the lesions. This enabled hepatic metastasectomy. The patient has remained in remission for 3 years.
Źródło:
OncoReview; 2016, 6, 4; A188-192
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Factors influencing serum chemerin and kallistatin concentrations in patients with alcohol-induced liver cirrhosis
Autorzy:
Prystupa, A.
Kiciński, P.
Luchowska-Kocot, D.
Sak, J.
Prystupa, T.K.
Tan, Y.-H.
Panasiuk, L.
Załuska, W.
Powiązania:
https://bibliotekanauki.pl/articles/2082078.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
alcohol-induced liver cirrhosis
chemerin
kallistatin
Opis:
Introduction. In Poland, an increasing number of patients are hospitalized due to liver diseases. One of the common liver diseases is cirrhosis, which can be caused by alcohol, viral hepatitis, autoimmune processes and metabolic diseases. Materials and method. The study included 99 patients with alcoholic cirrhosis from the Lublin region of Eastern Poland. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The concentrations of serum kallistatin and chemerin were determined using ELISA kits. Objective. The aim of the study is to evaluate serum levels of kallistatin and chemerin in patients with different stages of alcoholic liver cirrhosis. Results. The highest chemerin level was found in the control group – 182.6±80.4 ng/ml. In other stages of liver cirrhosis, the following levels were observed: 175.7±62.7 ng/ml in Child-Pugh stage A (Ch-P A), 150.2±59.7 ng/ml in Ch-P B and 110.3±73.6 ng/ml in Ch-P C. Significant differences in chemerin levels between controls and Ch-P C patients (p=0.01), as well as between the Ch-P A patients and Ch-P C patients (p=0.02), were demonstrated. The highest kallistatin level was demonstrated in the control group – 8.2±3.5 μg/ml. In other stages of liver cirrhosis, the following concentrations were found: 7.2±27 μg/ml in Ch-P A, 4.4±2.2 μg/ml in Ch-P B and 3.5±1.9 μg/ml in Ch-P C (Tab. 3). Statistically significant differences were observed between controls and Ch-P B patients (p<0.001), controls and Ch-P C patients (p<0.001), Ch-P A and Ch-P B patients (p=0.01), as well as Ch-P A and Ch-P C patients (<0.001). Conclusions. The levels of chemerin and kallistatin decrease with progression of liver damage during alcoholic liver cirrhosis. The impairment of its synthetic function leads to reductions in levels of the adipokines studied.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 143-147
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Peculiarities of liver functional state in the early period of cranioskeletal injury combined with bleeding, and its correction by cell therapy
Autorzy:
Zayets, T.A.
Gudyma, A.A.
Powiązania:
https://bibliotekanauki.pl/articles/1032349.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Kazimierza Wielkiego w Bydgoszczy
Tematy:
crinoskeletal injury
hemorrhage
liver
biligenic
bile excretion
fetal cells
Opis:
During the early manifestations of traumatic disease as a result of cranioskeletal injury (CSI) the content of total bile acids in bile is significantly reduced, biliary excretion is slowed, lithogenic properties of bile are increased. Intraperitoneal injection of fetal nerve cells in 12 hours after causing an injury accompanied by improvement of biligenic and biliary excretion liver functions, reduces the lithogenic properties of bile.
Źródło:
Journal of Health Sciences; 2014, 4, 1; 383-390
1429-9623
Pojawia się w:
Journal of Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease
Autorzy:
Lebensztejn, Dariusz
Wierzbicka, Aldona
Socha, Piotr
Pronicki, Maciej
Skiba, Elżbieta
Werpachowska, Irena
Kaczmarski, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1039852.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
NAFLD
laminin
cytokeratin-18
hyaluronic acid
YKL-40
children
Opis:
Objectives: There is a need to replace liver biopsy with non-invasive markers that predict the degree of liver fibrosis in fatty liver disease related to obesity. Therefore, we studied four potential serum markers of liver fibrosis and compared them with histopathological findings in liver biopsy in children with non-alcoholic fatty liver disease (NAFLD). Methods: We determined fasting serum level of hyaluronic acid (HA), laminin, YKL-40 and cytokeratin-18 M30 in 52 children (age range 4-19, mean 12 years, 80 % of them were overweight or obese) with biopsy-verified NAFLD. Viral hepatitis, autoimmune and metabolic liver diseases (Wilson's disease, alpha-1-antitrypsin deficiency, cystic fibrosis) were excluded. Fibrosis stage was assessed in a blinded fashion by one pathologist according to Kleiner. Receiver operating characteristics (ROC) analysis was used to calculate the power of the assays to detect liver fibrosis (AccuROC, Canada). Results: Liver fibrosis was diagnosed in 19 children (37 %). The levels of HA and CK18M30 were significantly higher in children with fibrosis compared to children without fibrosis (p=0.04 and 0.05 respectively). The ability of serum HA (cut-off 19.1 ng/ml, Se=84 %, Sp=55 %, PPV=52 %, NPV=86 %) and CK18M30 (cut-off 210 u/l, Se=79 %, Sp=60 %, PPV=56 %, NPV=82 %) to differentiate children with fibrosis from those without fibrosis was significant (AUC=0.672 and 0.666, respectively). The combination of both markers was superior (AUC=0.73, p=0.002). Laminin and YKL-40 levels did not allow a useful prediction. Conclusions: Cytokeratin-18 and hyaluronic acid are suitable serum markers predicting liver fibrosis in children with NAFLD. Studying these markers may identify patients at risk of disease progression.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 563-566
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sclerotherapy of esophageal varices in hemophilia patients with liver cirrhosis – a prospective, controlled clinical study
Autorzy:
Szczepanik, Andrzej B
Pielaciński, Konrad
Oses-Szczepanik, Anna M
Huszcza, Sławomir
Misiak, Andrzej
Dąbrowski, Wojciech P
Gajda, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/1392541.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
hemophilia
esophageal varices
bleeding
endoscopic sclerotherapy
liver cirrhosis
Opis:
Introduction: Bleeding from esophageal varices is a serious clinical condition in hemophilia patients due to congenital deficiency or lack of clotting factors VIII (in hemophilia A) and IX (in hemophilia B), decreased clotting factor II, VII, IX, X synthesis in the course of chronic liver disease and hipersplenic thrombocytopenia. The aim of this study was to assess the efficacy and safety of endoscopic sclerotherapy in acute esophageal variceal bleeding and in secondary prophylaxis of hemorrhage. The aim was also to investigate the optimal activity of deficiency factors VIII or IX and duration of replacement therapy required to ensure proper hemostasis after sclerotherapy procedures. Material and methods: 22 hemophilia patients (A-19, B-4) with coexistent liver cirrhosis and active esophageal variceal bleeding treated with endoscopic sclerotherapy were subjected to prospective analysis. The patients who survived were qualified to repeated sclerotherapy procedures every 3 weeks within secondary prophylaxis of bleeding (investigated group). A 3-day substitution therapy enhanced the infusion of the deficient or lacking factor in doses allowing to reach 80-100% of normal value activity of factor VIII on the 1st day and 60-80% in the next two days. The desired activity of factor IX was 60-80% and 40-60% respectively. The control group consisted of 20 non-hemophiliac patients with liver cirrhosis comparable in terms of age, sex, stage of advancement of liver cirrhosis, who underwent the same medical proceedings as the investigated group. Results: Active esophageal bleeding was stopped in 21 of 22 (95%) hemophilia patients. Complications were observed in 3 patients; 2 patients died. The rate of hemostasis, complications and deaths in the control group were comparable and no statistical differences were found. In hemophilia patients subjected to secondary prophylaxis of hemorrhage, in 18 of 20 (80%), complete eradication of esophageal varices was achieved after 4 to 7 sclerotherapy procedures in 1 patient (average 5.4). Recurrent bleeding was observed in 15% of patients, complication in 20%; 1 patient died. Time lapse from bleeding to eradication was 12-21 weeks (average 15.2). In the control group the rate of variceal eradication, complication and deaths was comparable and no statistical differences were found. The usage of factor VIII concentrates was as follows: in hemophilia A, in a severe form - 80.9 U/kg b.w./day, in hemophilia A in a severe form with an inhibitor <5 BU – 95.2 U/kg b.w./day, in mild form – 64.2 U/kg b.w./day and in severe hemophilia B – 91.6 U/kg b.w./day. Conclusions: Sclerotherapy is an effective method in the management of esophageal variceal bleeding in hemophilia patients. It is also effective for total eradication of varices when applied as a secondary prophylaxis of hemorrhage. In our opinion, a 3-day replacement therapy at the applied doses is sufficient to ensure hemostasis and avoid bleeding complications.
Źródło:
Polish Journal of Surgery; 2018, 90, 1; 29-34
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of diets containing heated fats on blood serum, heart and liver malondialdehyde and blood serum cholesterol in rats
Autorzy:
Tokarz, A
Postupolski, J.
Wojtkowski, P.
Powiązania:
https://bibliotekanauki.pl/articles/1371456.pdf
Data publikacji:
1992
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
diet
fat
blood serum
malondialdehyde
heated fat
heart
liver
cholesterol
rat
Źródło:
Polish Journal of Food and Nutrition Sciences; 1992, 01, 4; 67-77
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An unusual case of a tuberculous granuloma of the liver presenting thirteen years after intravesical BCG – therapy for bladder cancer
Autorzy:
Szczęsny, Wojciech
Szylberg, Łukasz
Słupski, Maciej
Marszałek, Andrzej
Szmytkowski, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/1391514.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
BCG therapy
bladder carcinoma
liver
tuberculous granuloma
Opis:
The authors present the case of a female patient with a tumor of segment VII of the liver, which was postoperatively identified as a tuberculous granuloma. The patient was admitted for elective surgery for a liver tumor, which had been diagnosed a few months before. Computed tomography and nuclear magnetic resonance were performed, based on which focal nodular hyperplasia was suspected. Thirteen years prior to admission the patient had undergone a transurethral resection of superficial bladder carcinoma, followed by adjuvant intravesical Bacillus Calmette-Guérin (BCG-therapy). Upon surgery, segment VII of the liver was resected; postoperative course was uneventful. After the identification of granuloma, the patient was referred to a phthysiatric clinic for further diagnostics and treatment. The authors have deemed this case worthy of reporting primarily due to the exceptionally long period between the completion of BCG therapy and the onset of hepatic tumor.
Źródło:
Polish Journal of Surgery; 2021, 93, 5; 1-5
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A proposal for calculating the no-observed-adverse-effect level (NOAEL) for organic compounds responsible for liver toxicity based on their physicochemical properties
Autorzy:
Jakubowski, Marek
Czerczak, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/2178862.pdf
Data publikacji:
2014-08-06
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
liver
NOAEL
LOAEL
organic compounds
physicochemical properties
Abraham’s Eq
Opis:
Objectives: Both environmental and occupational exposure limits are based on the no-observed-adverse-effect level (NOAEL), lowest-observed-adverse-effect level (LOAEL) or benchmark dose (BMD) deriving from epidemiological and experimental studies. The aim of this study is to investigate to what extent the NOAEL values for organic compounds responsible for liver toxicity calculated based on their physicochemical properties could be used for calculating occupational exposure limits. Material and Methods: The distribution coefficients from air to the liver (log $\text{K}_\text{liver}$) were calculated according to the Abraham solvation equation. NOAEL and LOAEL values for early effects in the liver were obtained from the literature data. The descriptors for Abraham's equation were found for 59 compounds, which were divided into 2 groups: "non-reactive" (alcohols, ketones, esters, ethers, aromatic and aliphatic hydrocarbons, amides) and "possibly reactive" (aldehydes, allyl compounds, amines, benzyl halides, halogenated hydrocarbons, acrylates). Results: The correlation coefficients between log-log K and log NOAEL for non-reactive and reactive compounds amounted to r = -0.8123 and r = -0.8045, respectively, and were statistically significant. It appears that the Abraham equation could be used to predict the NOAEL values for compounds lacking information concerning their liver toxicity. Conclusions: In view of the tendency to limit animal testing procedures, the method proposed in this paper can improve the practice of setting exposure guidelines for the unstudied compounds.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 4; 627-640
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Doświadczalna martwica wątroby u szczurów na tle niedoborów pokarmowych
Ehksperimental'nyjj nekroz pecheni u krys na fone nedoimki prodovol'stvija
Experimental dietary liver necrosis in rats
Autorzy:
Jampoler, I.
Krus, S.
Powiązania:
https://bibliotekanauki.pl/articles/875505.pdf
Data publikacji:
1958
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
choroby watroby
martwica watroby
niedobory pokarmowe
alfa-tokoferol
aminokwasy siarkowe
antybiotyki
badania na zwierzetach
szczury
liver disease
liver necrosis
nutrition deficiency
alpha-tocopherol
sulphur amino acid
antibiotic
animal experimentation
rat
Źródło:
Roczniki Państwowego Zakładu Higieny; 1958, 09, 3
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Resection of liver metastases from differentiated thyroid cancer: who might benefit? A report of 2 cases with review of literature
Autorzy:
Ligocka, Joanna
Patkowski, Waldemar
Szparecki, Grzegorz
Ostrowski, Tomasz
Wiechno, Wiesław
Zieniewicz, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1392133.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
iodine negative
liver surgery
thyroid neoplasms
Opis:
Background: Liver metastases of differentiated thyroid cancers (DTC) are uncommon. Surgery has proven to be effective in patients with 131I-negative hepatic lesions. Here, we present two patients who underwent liver resection for metastatic DTC. Case presentation: The first patient is a 36-year-old woman who reported with 70-mm hepatic metastases of papillary thyroid cancer. After primary treatment of cancer, she was disease-free for 8 years when the elevation of TSH levels resulted for the need to search for metastasis. Notably, the 131I SPECT did not show any lesions. The CT scan revealed an 80mm diameter mass in the liver. Histology confirmed metastasis of thyroid cancer. Lack of iodine uptake and the size of lesion excluded treatment with radioactive iodine. Radical resection of the metastasis was performed with good short- and long-term postoperative result. The second patient is a 65-year-old man previously treated for follicular thyroid cancer. When a iodine-negative 70mm diameter metastasis was detected within the liver, he was referred for surgery. Extended right hepatectomy was performed. In a 12-months follow-up, he remained stable, with no signs of recurrence. Conclusions: These two cases show that resection of hepatic metastases of DTC is an option even in the case of large lesions. Given the effectiveness and safety of liver surgery, we reckon that it should be the treatment of choice when possible. The decision to perform surgical treatment should be based on analysis of the ability to perform radical and safe resection.
Źródło:
Polish Journal of Surgery; 2019, 91, 4; 52-56
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mineral content in leg muscle and liver of coypu : myocastor coypus
Zawartość składników mineralnych w udźcu i w wątrobie nutrii : myocastor coypus
Autorzy:
Cholewa, R.
Beutling, D.
Mleczek, M.
Arndt, G.
Powiązania:
https://bibliotekanauki.pl/articles/270626.pdf
Data publikacji:
2014
Wydawca:
Centralny Ośrodek Badawczo-Rozwojowy Aparatury Badawczej i Dydaktycznej, COBRABiD
Tematy:
coypu
leg muscle
liver
mineral content
nutria
udziec
wątroba
zawartość składników mineralnych
Opis:
Leg muscle and liver samples of 25 coypu were used for analysis of mineral content. Total elements content was analyzed by flame atomic absorption spectrometry (FAAS) and electrothermal atomic absorption spectrometry (ETAAS). The content of arsenic was analyzed by hydride generous atomic absorption spectrometry (HGAAS). Mean values and standard deviations of aluminium (Al), arsen (As), cadmium (Cd), cobalt (Co), chrome (Cr), copper (Cu), iron (Fe), potassium (K), manganese (Mn), molybdenum (Mo), sodium (Na), nickel (Ni), lead (Pb), selenium (Se), strontium (Sr) and zinc (Zn) were calculated. For each mineral the contents in the liver were higher than in the muscle for all animals. The highest average contents had Na (muscle 2227.51 mg/kg, liver 4123.7 mg/kg) and K (muscle 1081.00 mg/kg, liver 3256.06 mg/kg). Zinc had the highest concentration of microelements in muscle, in decreased line follow the means of Fe, Cu, Mn, Se and Ni. The means of trace elements follow with Sr, Cd, Cr, Mo, Al, Co, Pb and As. The medians of the ratio content of liver to content of muscle were for Mn 5, for Mo and Se 4, for Cu and K 3, for Co and Fe 2.5, for the other minerals between 1.2 and 2. It couldn't be shown a correlation between liver and muscle mineral content. Some statistical significant differences between age and sex of coypu were found. These differences must be interpreted cautiously because of the situation of multiple tests.
Do analizy zawartości składników mineralnych wykorzystano próbki z udźca i wątroby 25 nutrii. Całkowitą zawartość składników analizowano metodami FAAS i ETAAS. Zawartość arsenu oznaczano metodą HGAAS. Obliczono wartości średnie i odchylenia standardowe glinu (Al), arsenu (As), kadmu (Cd), kobaltu (Co), chromu (Cr), miedzi (Cu), żelaza (Fe), potasu (K), manganu (Mn), molibdenu (Mo), sodu (Na), niklu (Ni), ołowiu (Pb), selenu (Se), strontu (Sr) i cynku (Zn). W wątrobie wszystkich zwierząt zawartość tych składników mineralnych była większa niż w ich udźcu. Największą średnią zawartość miał sód (Na): (udziec 2227,51 mg/kg, wątroba 4123,7 mg/kg) i potas (K): (udziec 1081,00 mg/kg, wątroba 3256,06 mg/kg). Największą koncentrację mikroelementów w udźcu miał cynk (Zn), innych średnie zmniejszały się w kolejności: Fe, Cu, Mn, Se i Ni. Średnie pierwiastków śladowych następowały w kolejności: Sr, Cd, Cr, Mo, Al, Co, Pb i As. Stosunek zawartości składników wątroby do składników udźca wynosił dla Mn 5, dla Mo i Se 4, dla Cu i K 3, dla Co i Fe 2,5, a dla innych składników między 1,2 i 2. Nie pojawiła się korelacja między zawartością składników mineralnych wątroby i udźca. Znaleziono niektóre, statystycznie istotne różnice, między wiekiem nutrii obu płci. Te różnice powinny być ostrożnie interpretowane z powodu sytuacji wielostronnego badania.
Źródło:
Aparatura Badawcza i Dydaktyczna; 2014, 19, 1; 7-14
2392-1765
Pojawia się w:
Aparatura Badawcza i Dydaktyczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wybrane aspekty opieki pielęgniarskiej wobec pacjentki z marskością wątroby w przebiegu choroby Wilsona
Selected aspects of nursing care for a patient with liver cirrhosis in the course of Wilsons disease
Autorzy:
Szambelan, Julita
Haor, Beata
Pietrzak, Monika
Powiązania:
https://bibliotekanauki.pl/articles/1029624.pdf
Data publikacji:
2018
Wydawca:
Państwowa Uczelnia Zawodowa we Włocławku
Tematy:
wilson's disease
nursing process
icnp®
liver cirrhosis
Opis:
Introduction. Wilson's disease is a real threat to patients' quality of life. It leads to significant neurological deficits, psychiatric disorders and mainly severe liver dysfunctions. Aim. The aim of the study is to analyse selected aspects of nursing care for a patient in the course of Wilson's disease, using terms derived from ICNP®. Case study. The case report concerns a patient at a young age ,hospitalised due to exacerbation of Wilson's disease symptoms. Discussion. Wilson's disease mainly affects young people. Therefore, it is necessary to design such nursing care, which, apart from solving the somatic problems of the patient, does not affect their autonomy and minimizes deficits in the scope of social roles performed so far. Conclusions. The use of ICNP® in the planning of nursing care for a patient in the course of Wilson's disease may significantly support the implementation of systematic actions aimed at improving the quality of her life.
Wstęp. Choroba Wilsona stanowi realne zagrożenie dla jakości życia pacjentów. Prowadzi bowiem do istotnych deficytów neurologicznych, zaburzeń o podłożu psychiatrycznym a głównie poważnych dysfunkcji wątroby. Cel pracy. Celem opracowania analiza wybranych aspektów opieki pielęgniarskiej wobec pacjentki w przebiegu choroby Wilsona, z wykorzystaniem terminów zaczerpniętych z ICNP®. Prezentacja przypadku. Opis przypadku dotyczy pacjentki w młodym wieku hospitalizowanej w związku z zaostrzeniem objawów choroby Wilsona. Dyskusja. Choroba Wilsona dotyczy głównie osób młodych. Niezbędne jest zatem projektowanie takiej opieki pielęgniarskiej, która poza rozwiązywaniem somatycznych problemów chorego, nie narusza ich autonomii i minimalizuje deficyty w zakresie dotychczas pełnionych ról społecznych. Wnioski. Zastosowanie ICNP® w planowaniu opieki pielęgniarskiej wobec pacjentki w przebiegu choroby Wilsona może istotnie sprzyjać wdrażaniu systematycznych działań służących poprawie jakości jej życia.
Źródło:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 1; 82-103
2451-1846
Pojawia się w:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of phenobarbital on gene expression levels of p53 and DNMT1 in the liver of Wistar rats
Autorzy:
Urbanek-Olejnik, K.
Liszewska, M.
Kostka, G.
Powiązania:
https://bibliotekanauki.pl/articles/874211.pdf
Data publikacji:
2014
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
phenobarbital
gene expression
animal exposure
rat
p53 gene
Dnmt1 gene
liver
Wistar rat
Opis:
Background. Our previous studies have shown that short-term treatment with phenobarbital (PB) resulted in cytosine methylation of CpG sites on the p53 gene promoter in male Wistar rats’ liver. Furthermore, PB induced DNA-methyltransferases (DNMTs) activity was also demonstrated; being the enzymes that catalyze methyl group transfer to cytosine in CpG dinucleotides. Objective. Since DNA methylation is involved in regulating gene transcription and that DNMT1 is implicated in regulating DNA methylation, this study assessed whether PB-induced hypermethylation of the p53 promoter region was associated with an altered expression of p53 and Dnmt1 genes. Material and methods. Male Wistar rats received PB in three daily oral doses (at 24-h intervals) of 92,8 mg/kg b.w. x day-1. Levels of mRNA for p53 and Dnmt1 and levels of relevant proteins were respectively examined by Real-Time PCR and Western blot analysis. Results. Gene expression analysis revealed that exposure of Wistar rats to PB caused statistically significant alternations in the expression of tested genes. We found that both mRNA and protein expression of p53 was down-regulated, whereas expression of Dnmt1 (both mRNA and protein) was up-regulated after PB treatment. Conclusions. Suppression of p53 mRNA and protein expression, which is probably a result of epigenetic changes, (in particular aberrant p53 promoter hypermethylation), can be associated with tumour promoting activity of phenobarbital.
Wprowadzenie. Nasze wcześniejsze badania wykazały, że krótkoterminowe narażenie szczurów Wistar na fenobarbital (PB) stymulowało metylację cytozyny w badanych sekwencjach rejonu promotorowego genu p53. Ponadto stwierdzono wzrost aktywności metylotransferaz DNA (DNMT), enzymów które katalizują przenoszenie grupy metylowej do cytozyny w dinukleotydach CpG. Cel badań. Z uwagi że metylacja DNA pełni istotną rolę w ekspresji genów, a DNMT1 uczestniczy w regulacji metylacji DNA, w prezentowanych badaniach oceniano czy indukowana PB hipermetylacja rejonu promotorowego genu p53 była związana ze zmianami ekspresji genów p53 i Dnmt1. Materiał i metody. Samce szczurów szczepu Wistar otrzymywały PB w dawce 92,8 mg/kg m.c. x dzień-1, 3-krotnie w odstępach dobowych. Analizę poziomu transkryptów i białek badanych genów przeprowadzano odpowiednio metodą Real- -Time PCR i Western blot. Wyniki. W wyniku oddziaływania PB wykazano obniżoną ekspresję genu p53 i wzrost ekspresji metylotranserazy 1 (DNMT1). Wnioski. Supresja ekspresji p53 (na poziomie mRNA i białka) będąca prawdopodobnie wynikiem zmian epigenetycznych, w szczególności hipermetylacji jego rejonu promotorowego może być związana z promocyjną aktywnością fenobarbitalu.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2014, 65, 3
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Afamin and adropin in patients with alcohol-induced liver cirrhosis
Autorzy:
Prystupa, A.
Kiciński, P.
Luchowska-Kocot, D.
Sak, J.
Prystupa, T.
Chen, K.-H.
Chen, Y.-H.
Panasiuk, L.
Załuska, W.
Powiązania:
https://bibliotekanauki.pl/articles/2081906.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
alcoholic liver cirrhosis
Adropin
Child-Pugh score
afamin
Opis:
The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA kits. The concentration of afamin was found to be significantly lower in patients with compensated alcoholic liver cirrhosis, i.e. P-Ch B (85.1±40.6 μg/ml) and P-Ch C (56.4±32.3 μg/ml) individuals, compared to the control group (135.9±43.6 μg/ml); p-value was <0.01 and <0.001, respectively. As far as adropin is concerned, a reverse relationship was demonstrated: the highest concentration was found in patients with P-Ch C (11.7±5.7 ng/ml) cirrhosis. Furthermore, the above concentration was significantly higher compared to patients with P-Ch A cirrhosis (7.2±2.8 ng/ml; p<0.05) and controls (7.5±2.6 ng/ml; p<0.05). The concentration of afamin decreases with the severity of alcoholic liver cirrhosis, which most likely results from impaired hepatic synthesis. Otherwise, the higher the stage of disease according to the Child-Pugh score, the higher the concentration of adropin.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 3; 527-531
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prognostic value of perioperative assessment of plasma cardiac troponin I in patients undergoing liver transplantation
Autorzy:
Jankowski, Krzysztof
Trzebicki, Janusz
Bielecki, Maksymilian
Łągiewska, Beata
Kurnicka, Katarzyna
Koczaj-Bremer, Magdalena
Pacholczyk, Marek
Pruszczyk, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1038657.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cardiac troponin I
liver transplantation
surgery time
Opis:
Abstract. An elevation in plasma cardiac troponins is an indicator of increased perioperative risk in orthopaedic and vascular surgery, however, data on liver transplantation (LTx) are scarce. The aim of the study was to evaluate the prevalence of cardiac troponin I (cTnI) elevation in the perioperative period of LTx, and its potential relationship with 1-year mortality. Material and methods. Analysis included 79 patients with liver cirrhosis. During LTx all patients underwent hemodynamic measurements. cTnI level was determined before the operation, 24, 48 and 72 hours afterwards. One-year mortality was assessed. Results. 12.7% patients died, all during in-hospital period. cTnI level on day 1. was identified as the most promising marker of increased death risk with optimal cut-off value of 0.215 ng/mL (the sensitivity of 60.0%, specificity of 87.0%, positive predictive value of 40.0%, negative predictive value of 93.8%). The most important predictor of cTnI increase was the duration of the LTx procedure followed by amount of packed red blood cells transfused, basic stroke volume index, and cardiac output index. In conclusion: value of cTnI level assessed 24 hours post-surgery was a reliable predictor of death following LTx with optimal cut-off value of 0.215 ng/mL. The surgery time was the most important predictor of cTnI elevation.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 331-337
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of mercury in muscles, liver and gills of marine and freshwater fish
Autorzy:
Luczynska, J.
Luczynski, M.J.
Paszczyk, B.
Powiązania:
https://bibliotekanauki.pl/articles/13699.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
fish
total mercury
mercury
muscle
liver
gill
marine fish
freshwater fish
body weight
total length
biotic factor
condition factor
Opis:
In this study, the total mercury concentration was determined in the muscles, liver and gills of six fish species (rainbow trout Oncorhynchus mykiss Walb., carp Cyprinus carpio L., bream Abramis brama L., perch Perca fluviatilis L., ide Leuciscus idus L. and flounder Platichthys flesus L.). The fish were acquired from October to November 2012. Mercury was analyzed by atomic absorption spectrometry using thermal decomposition, compounds of mercury and amalgamation. The mercury content in fish organs reached 0.006-0.168 (in mg kgˉ¹ wet weight) in muscles, 0.001-0.027 in gills and 0.003-0.045 in the liver. The muscles of perch and ide had significantly more Hg compared to the other fish’s muscles (P≤0.05). The liver and gills of perch, ide and flounder contained more Hg than the same tissues of the other fish (P≤0.05). Generally, the highest Hg content was determined in muscles (except rainbow trout) (P≤0.05), whereas the lowest Hg content was found in gills (except perch) (P≤0.05). The content of Hg in gills of perch did not differ from the one in the liver (P>0.05). There was a positive correlation between the weight or length of a fish and the Hg concentration in its tissues, except for the length and Hg in the gills of carp. However, a statistically significant positive correlation between the body weight and the Hg levels in fish appeared only in the case of the organs of ide (P≤0.004) and muscles of carp (P≤0.038). The correlation between the factor condition and the content of Hg, albeit positive (0.106 < r < 0.811) except for the organs of flounder, was not statistically significant (P>0.05).
Źródło:
Journal of Elementology; 2016, 21, 1
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ekstrakcja cech teksturalnych w klasyfikacji obrazów tomograficznych wątroby
Texture feature extraction in liver CT image analysis
Autorzy:
Duda, D.
Krętowski, M.
Bézy-Wendling, J.
Powiązania:
https://bibliotekanauki.pl/articles/341025.pdf
Data publikacji:
2007
Wydawca:
Politechnika Białostocka. Oficyna Wydawnicza Politechniki Białostockiej
Tematy:
klasyfikacja obrazów medycznych
analiza tekstury
tomografie komputerowe wątroby
computer-aided diagnosis
texture analysis
liver CT images
Opis:
W pracy przedstawiono nową metodę opisu tekstur, przystosowaną do analizy grupy obrazów, przedstawiających na różne sposoby ten sam fragment organu. Charakteryzując obszary zainteresowania, uwzględniono nie tylko cechy teksturalne wyliczone na ich podstawie, ale również ich zależność od warunków pozyskiwania obrazów. Zaproponowano kilka sposobów konstrukcji przestrzeni parametrów odzwierciedlających zmianę tekstury, która zachodzi pod wpływem zmian warunków akwizycji. Proponowaną metodę zweryfikowano doświadczalnie w klasyfikacji obrazów tomograficznych wątroby. Rozpoznawano cztery typy tkanki, dla każdego przypadku rozważono trzy momenty akwizycji, związane z obecnością i propagacją środka kontrastującego. Wyniki uzyskane przy użyciu różnych zestawów cech teksturalnych i klasyfikatora w postaci dipolowych drzew decyzyjnych pokazują, że uwzględnienie zmian tekstury pod wpływem propagacji środka kontrastującego znacznie poprawia diagnozę.
In the work, a new method of texture characterization from multiple scan series is presented. Images with the same slice position, acquired at different conditions, are analyzed simultaneously. Thereby not only texture characteristics of the considered region of interest are taken into account, but also their variations over the different acquisition moments. A few approaches to description of these variations were proposed. They were applied in recognition of four types of hepatic tissue. Liver CT images were acquired during the three typical phases related to presence and propagation of contrast material. Experiments with various sets of texture parameters and dipolar decision tree as a classifier showed that simultaneous analysis of texture features derived from three subsequent acquisition moments could considerably improve the classification accuracy.
Źródło:
Zeszyty Naukowe Politechniki Białostockiej. Informatyka; 2007, 2; 51-66
1644-0331
Pojawia się w:
Zeszyty Naukowe Politechniki Białostockiej. Informatyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Semantic segmentation and PSO based method for segmenting liver and lesion from CT images
Autorzy:
Nayantara, Vaidehi P.
Surekha, Kamath
Manjunath, K.N.
Rajagopal, Kadavigere
Powiązania:
https://bibliotekanauki.pl/articles/2146955.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
liver lesion segmentation
computed tomography
semantic segmentation
SegNet
particle swarm optimization-based clustering
Hounsfield Unit
Opis:
The liver is a vital organ of the human body and hepatic cancer is one of the major causes of cancer deaths. Early and rapid diagnosis can reduce the mortality rate. It can be achieved through computerized cancer diagnosis and surgery planning systems. Segmentation plays a major role in these systems. This work evaluated the efficacy of the SegNet model in liver and particle swarm optimization-based clustering technique in liver lesion segmentation. Over 2400 CT images were used for training the deep learning network and ten CT datasets for validating the algorithm. The segmentation results were satisfactory. The values for Dice Coefficient and volumetric overlap error achieved were 0.940 ± 0.022 and 0.112 ± 0.038, respectively for liver and the results for lesion delineation were 0.4629 ± 0.287 and 0.6986 ± 0.203, respectively. The proposed method is effective for liver segmentation. However, lesion segmentation needs to be further improved for better accuracy.
Źródło:
International Journal of Electronics and Telecommunications; 2022, 68, 3; 635--640
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contribution of semiquantitative analysis with dynamic contrast enhanced magnetic resonance imaging to the differential diagnosis of focal liver lesions
Autorzy:
Düzkalır, Hanife Gülden
Kış, Naciye
Urgun, Deniz Akay
Ağaçlı, Mehmet Oğuzhan
Kılıçoğlu, Zeynep Gamze
Powiązania:
https://bibliotekanauki.pl/articles/25102539.pdf
Data publikacji:
2023-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
adult liver cancer
benign hepatoma
perfusion imaging
Opis:
Introduction and aim. We aimed to evaluate the usefulness of dynamic contrast-enhanced (DCE) MRI semiquantitative analysis values in focal liver lesions (FLL) to provide additional qualities that can be used in daily practice in the differential diagnosis of lesions. Material and methods. This retrospective study included 91 patients with liver masses on DCE-MRI. The sensitivity and specificity of time intensity curves (TIC) and semiquantitative analysis values were evaluated to differentiate benign and malignant lesions. Results. The study included 91 patients (376 lesions), aged between 28-81 years. Of the lesions, 303 were malignant and 73 were benign. In TIC semiquantitative analysis, it was found that “Tpeak” and “wash-out” rate values showed differences, especially in the differentiation of HCC, metastasis, and hemangioma. Area under curve, maximum relative enhancement, and “wash-in” and “wash-out” values of metastases and hemangiomas were different. Brevity of enhancement values of HSK, hemangiomas, and metastases were found to be different. The risk of malignancy was found to be high when the “wash-out” ratio was above 0.08 (sensitivity: 64.3%, specificity: 70.4%). Conclusion. We think that the 0.08 threshold value we found for the washout ratio with DCE-MRI semiquantitative analysis data will be useful in daily practice in the differentiation of malignant and benign FLL.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 2; 344-356
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł

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