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Tytuł:
Female mouse model of diabetes mellitus induced by streptozotocin and high-carbohydrate high-fat diet
Autorzy:
Guo, R.
Dong, J.
Wang, D.Q.
Gu, Y.F.
Powiązania:
https://bibliotekanauki.pl/articles/16627528.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
diabetes mellitus
female mouse
pathological analysis
streptozotocin
high-carbohydrate high-fat diet
Opis:
With the improvement of people’s living standards and rapid economic development, the incidence of diabetes mellitus (DM) is increasing in most parts of the world. DM presents an important potential threat to human health. In the present study, a model of diabetes in female mice was established, and fasting blood glucose was detected at week 4, after which the biochemical profiles were evaluated by histopathological analysis. The success rate of modeling in the normal control (NC) group and the low/ middle/high-dose streptozotocin (STZ) group were 0, 0, 25% and 60%, respectively. In the middle-dose and high-dose STZ groups, the liver index was increased significantly compared with the NC group (p<0.05). The blood biochemical indicators of total cholesterol and low density lipoprotein cholesterol in three STZ injection groups were as follows: alanine aminotransferase and aspartate transaminase in middle- and high-dose STZ groups, high-density lipoprotein cholesterol and serum creatinine in the high-dose STZ group, and blood urea nitrogen in the middle-dose STZ group were significantly increased (p<0.05). The level of total triglycerides was lower, obviously, in the high-dose STZ group than in the NC group (p<0.05). The mice showed marked steatosis, green-dyed fiber tissue coloring in varying degrees, and the contour of the hepatic lobules basically disappeared in STZ injection groups. The results suggest that to establish a diabetes model for female ICR mice, the optimum dose of STZ is 100 mg/kg.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 4; 547-555
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in Rats
Autorzy:
Stępniowska, Anna
Juśkiewicz, Jerzy
Tutaj, Krzysztof
Fotschki, Joanna
Fotschki, Bartosz
Ognik, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/2159288.pdf
Data publikacji:
2022-09-05
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
minerals
chromium
nanoparticles
high-fat diet
Opis:
The metabolism of chromium (Cr), calcium (Ca), phosphorus (P), iron (Fe), copper (Cu), and zinc (Zn) is interconnected, and their deficiency or excessive accumulation may lead to various disturbances, including anemia and diabetes. The current research was undertaken to determine whether low-fat or high-fat diets with the Cr(III) addition in the form of picolinate (CrPic) or nanoparticles (CrNPs) have an interactive effect on the retention and accumulation of this element in organs and the content of P, Ca, Fe, Cu and Zn in the blood plasma of rats. The experiment was performed using 48 outbred male Wistar rats fed a low-fat or high-fat semi-purified rat diet with dietary addition of chromium at a dose of 0.3 mg/kg body weight. The obtained results point to the paramount importance of the dietary Cr form on the excretion pattern of this microelement. It has been found that CrNPs were to a greater extent excreted from the rat’s body via urine and feces in comparison to CrPic, as indicated by the values of the Cr retention index (44.4 vs. 65.9%, respectively). The additional dietary Cr, irrespective of its form and diet type, was not accumulated in the analyzed internal organs, i.e. brain, spleen, kidneys, liver, thigh bone, and thigh muscle. It should be stressed that dietary CrPic, unlike CrNPs, added to the high-fat diet adversely reduced plasma concentration of vital minerals in comparison to the levels observed in rats fed the low-fat diet, i.e. Zn (60.5 vs. 69.9 µM), Cu (13.6 vs. 15.7 µM), and P (1.12 vs. 1.30 µM). In turn, the CrNPs, but not CrPic, added to the high-fat diet decreased plasma Fe level (1.41 vs. 2.43 µM).
Źródło:
Polish Journal of Food and Nutrition Sciences; 2022, 72, 3; 229-238
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of high fat diet on structure of liver and gallbladder of adult male mice – an experimental study
Autorzy:
Hegazy, Abdelmonem Awad
Qenawy, Noura M.
Aziz, Nada M. Abdel
El-Bestawy, Emtethal M.
Powiązania:
https://bibliotekanauki.pl/articles/2040247.pdf
Data publikacji:
2021-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
COX-2
fatty liver
gallbladder epithelium
immunoexpression
Oil Red O staining
Opis:
Introduction. High fat diet (HFD) intake induces obesity and adversely affects different body organs including liver and gallbladder. Aim. It was to clarify the effects of HFD on the liver and gallbladder structure using light microscopic (LM) examination. Material and methods. 16 healthy adult male mice were equally divided into 2 groups. Control group mice were fed normal diet. HFD group was fed using HFD. At the end of the 8-week experiment, mice were anesthetized. Liver and gallbladder were removed and prepared to histological processing. Sections were stained with hematoxylin and eosin (H&E) and immunostaining for cyclooxygenase-2 (COX-2) cellular localization. Oil Red O (ORO)-stained frozen liver sections were prepared. Results. H&E-stained sections of HFD group revealed rounded swollen hepatic cells with pale cytoplasm suggesting cellular ballooning. Dilated congested sinusoids and portal vein, cellular degeneration and collection of inflammatory cells were observed between hepatic cells and in portal region. Gallbladder sections showed epithelial stratification and cellular vacuolation. Strong immunoexpression of COX-2 was observed in Kupffer and hepatic cells of the liver and gallbladder mucosal epithelial cells. Conclusion. HFD is suggested to alter the normal histological features of liver and gallbladder represented by fatty liver and gallbladder epithelial hyperplasia and inflammatory reaction.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 4; 291-298
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of bergenin on the kidney of C57BL/6J mice with high fat-diet induced oxidative stress
Autorzy:
Sagadevan, A.
Ramalingam, S.
Powiązania:
https://bibliotekanauki.pl/articles/11714.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Opis:
The present study evaluated the protective effect of bergenin on high fat diet (HFD) induced diabetic mice. C57BL/6J mice were segregated in two groups, one fed standard diet (NC) and the other fed HFD for 16 weeks. Mice were fed continuously with high fat diet for 16 weeks and subjected to intragastric administration of bergenin (10, 20 and 40 mg/kg body weight (BW)), metformin (25 mg/kg BW) 9 to 16 weeks. At the end of the treatment nephritic markers, lipid peroxidation product, antioxidant and histopathological examination were carried out to assess the efficacy of the treatment. HFD fed mice showed increased plasma glucose, insulin, altered nephritic markers, antioxidant and histopathological abnormalities. Oral Treatment with bergenin (40 mg/kg BW) showed near normalized levels of plasma glucose, lipid peroxidation product, antioxidants, improved insulin and reduced kidney damage. The effects of bergenin were comparable with standard drug, metformin. These data suggest that bergenin protect kidney from deleterious effect of glucose.
Źródło:
International Letters of Natural Sciences; 2016, 54
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spirulina Platensis Affects Factors Involved in Spermatogenesis and Increases Ghrelin Receptors in Testis Tissue of Rats Fed a High-Fat Diet
Autorzy:
Esener, O.B.B.
Gurel-Gurevin, E.
Isbilen-Basok, B.
Yigit, F.
Bilal, T.
Altiner, A.
Yilmazer, N.
Armutak, E.I.
Powiązania:
https://bibliotekanauki.pl/articles/2087925.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Źródło:
Polish Journal of Veterinary Sciences; 2017, 3; 467-475
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression Profile of Brain Aging and Metabolic Function are Altered by Resveratrol or α-Ketoglutarate Supplementation in Rats Fed a High-Fat Diet
Autorzy:
Szczurek-Janicka, Paulina
Ropka-Molik, Katarzyna
Oczkowicz, Maria
Orczewska-Dudek, Sylwia
Pietras, Mariusz
Pieszka, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1363257.pdf
Data publikacji:
2021
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
α-ketoglutarate
brain aging
gene expression profiling
high-fat diet
resveratrol
rats
Opis:
The aim of this study was to examine the impact of different dietary interventions started at middle age on the metabolic phenotype and gene expression profiling in the hypothalamus. One-year old rats were fed either a control diet, high-fat diet (HFD), HFD supplemented with resveratrol (HFD+RESV), or HFD supplemented with α-ketoglutarate (HFD+AKG). A 6-week HFD feeding led to significant changes in concentrations of plasma glucose, insulin, lipids, and thyroid hormones. Moreover, 32% of the 84 analyzed genes correlated with aging were differentially expressed compared to the control group, with the largest functional class being related to inflammatory response. Dietary RESV ameliorated the changes in plasma glucose, total cholesterol, and triiodothyronine concentrations induced by HFD feeding and significantly downregulated 60% of the surveyed genes compared to the control group, resulting in a major molecular shift compared to HFD alone. In contrast, AKG supplementation did not affect the metabolic phenotype, but prevented the gene expression pattern caused by HFD consumption, mimicking the effects observed in the control group. HFD feeding induces metabolic dysfunction and age-related genetic alterations in the hypothalamus of middle-aged rats, while dietary RESV or AKG may partially retard these effects, even though these compounds act in a different and specific manner.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2021, 71, 3; 255-268
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of Inula helenium rhizomes and Matricaria chamomilla inflorescences on the biochemical and physiological parameters in male rats fed a high-fat diet
Autorzy:
Lieshchova, M.
Yefimov, V.
Brygadyrenko, V.
Powiązania:
https://bibliotekanauki.pl/articles/28763546.pdf
Data publikacji:
2023
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Opis:
Background. Pharmacological correction of a high-fat diet is of great interest to prevent the development of obesity and hypertension. More and more research is being done on the preventive use of medicinal herbs for excess caloric intake. Objective. The aim of this study was to determine the general physiological effect of I. helenium rhizomes and M. chamomilla inflorescences used in the diet of male rats consuming excess amounts of fat and calories in the daily diet. Material and methods. In a 30-day experiment, we determined the effect of I. helenium rhizome and M. chamomilla on the physiological activity and metabolic processes of laboratory rats consuming a high-fat diet. The physical activity was evaluated according to the mass gain of animals and change in the relative mass of the internal organs, and also the functional conditions of the central nervous system. The influence on the metabolic processes was revealed by biochemical and clinical blood analyses. Results. In a laboratory experiment on male rats, it was found that the addition of dry crushed rhizomes of Inula helenium L. and inflorescences of Matricaria chamomilla L. to the diet caused opposite changes in body weight. In the control group, the animals slightly increased their body weight (up to 111.5% of the initial weight by the end of the experiment); the rhizomes of I. helenium caused a decrease in body weight gain (up to 105.5% on the 30th day of the experiment compared to the initial weight); rats fed M. chamomilla inflorescences gained 123.2% of their initial body weight during the month of the experiment. The rhizomes of I. helenium caused an increase in the stomach relative mass. A decrease in the thymus relative weight was observed when animals were fed M. chamomilla inflorescences. The rhizomes of I. helenium stimulated an increase of blood protein concentration (mainly due to globulins), an increase in the alkaline phosphatase activity and cholesterol, and a decrease in the triglycerides concentration. M. chamomilla inflorescences reduced the blood urea concentration and increased the activity of alkaline phosphatase, causing strong changes in fat metabolism. Under the influence of the diet with the addition of M. chamomilla inflorescences, the atherogenic index increased in animals by 6.5 times relatively to the control group (due to a decrease in the concentration of high-density lipoprotein cholesterol and an increase in the concentration of low-density lipoprotein cholesterol, an increase in the total cholesterol concentration). When M. chamomilla was added to the diet, the blood triglycerides concentration in animals decreased sharply and the concentration of leukocytes increased. The concentration of monocytes exceeded the limits of the physiological norm both in the control group and in the group of animals fed on M. chamomilla inflorescences. Conclusions. The results of the studies show the promise for further research of I. helenium rhizomes in the prevention of hypertension and also indicate strong risks when using M. chamomilla inflorescences for preventive purposes during high-fat and hypercaloric diet.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2023, 74, 4; 447-458
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oral Supplementation with Three Vegetable Oils Differing in Fatty Acid Composition Alleviates High-Fat Diet-Induced Obesity in Mice by Regulating Inflammation and Lipid Metabolism
Autorzy:
Aldamarany, Waleed
Taocui, Huang
Liling, Deng
Wanfu, Yang
Zhong, Geng
Powiązania:
https://bibliotekanauki.pl/articles/16538537.pdf
Data publikacji:
2023-02-28
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
perilla oil
sunflower oil
tea seed oil
anti-obesity effect
inflammation
lipid metabolism
Opis:
Obesity has become one of the most prevalent chronic diseases worldwide, which affects people's health and daily lives. Therefore, this study aimed to investigate the anti-obesity effects of perilla seed oil (PSO), sunflower oil (SFO), and tea seed oil (TSO) and their potential mechanisms in mice fed a high-fat diet (HFD). Mice were divided into five groups: ND, mice fed a normal diet; HFD, mice fed a high-fat diet; PSO, SFO, and TSO, mice fed a high-fat diet supplemented with PSO, SFO, and TSO at 2 g/kg body weight per day, respectively. Our findings showed that oral supplementation with all three oils for 8 weeks significantly reduced body weight, tissue weight, insulin resistance index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and free fatty acids (FFA), and markedly alleviated hyperglycemia, hyperlipidemia, and hepatic steatosis in obese mice. It also decreased leptin, pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and (IL)-1beta (IL-1β), and increased anti-inflammatory adipokine adiponectin at both secretion and mRNA expression levels in the epididymal adipose tissue (EAT). Moreover, PSO, SFO, and TSO administration increased the expression levels of fatty acid β-oxidation-related genes, including peroxisome proliferator-activated receptor-alpha (PPAR-α), carnitine palmitoyltransferase 1a (CPT1a) and CPT1b, and thermogenesis-related genes such as uncoupling protein 1 (UCP1), and decreased the expression levels of lipid synthesis-related genes, including fatty acid synthase (FAS) and PPAR-γ in EAT. In conclusion, PSO, SFO, and TSO supplementation could have potential anti-obesity effects in HFD-fed mice by reducing inflammation and improving lipid metabolism.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2023, 73, 1; 80-94
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ kwasu α-liponowego na procesy wolnorodnikowe w surowicy szczurów utrzymywanych na diecie wysokotłuszczowej
Effect of α-lipoic acid on free radical processes in serum of rats on high fat diet
Autorzy:
Cichoń, Marcin
Błaszczyk, Urszula
Zalejska-Fiolka, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2164107.pdf
Data publikacji:
2017-05-16
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
dieta wysokotłuszczowa
dialdehyd malonowy
grupa sulfhydrylowa
kwas liponowy
nadtlenki lipidowe
kreatynina
high fat diet
malondialdehyde
sulfhydryl groups
lipoic acid
lipid peroxides
creatinine
Opis:
Wstęp Proces smażenia olejów roślinnych prowadzi do obniżenia ich właściwości biologicznych i żywieniowych oraz w konsekwencji do zaburzeń homeostazy organizmu. Czynnikami wspomagającym stabilność olejów są substancje o charakterze antyoksydacyjnym. Celem pracy było określenie wpływu kwasu α-liponowego na stężenie grup sulfhydrylowych, nadtlenków lipidowych, dialdehydu malonowego oraz kreatyniny i mocznika w surowicy szczurów utrzymywanych 3 miesiące na diecie wysokotłuszczowej wzbogaconej w olej rzepakowy poddany obróbce wysokotemperaturowej. Materiał i metody Materiał stanowiło 36 szczurów podzielonych równo na 6 grup: kontrolną utrzymywaną na hodowlanej paszy standardowej (hodowlana dieta standardowa – HDS), grupę OU (HDS z 10% dodatku oleju utlenionego (OU)), grupę ALA10 (HDS z dodatkiem kwasu α-liponowego (ALA) w dawce 10 mg/kg masy ciała (mc.)), grupę OU+ALA10 (HDS z dodatkiem utlenionego oleju oraz ALA jw.), grupę ALA50 (HDS z dodatkiem ALA w dawce 50 mg/kg mc.) i grupę OU+ALA50 (HDS z dodatkiem utlenionego oleju oraz ALA jw.). Olej był utleniany w 180°C przez 6 godz. Wyniki Zaobserwowano obniżenie stężenia grup sulfhydrylowych (protein sulfhydryl groups – PSH) dla wszystkich grup badanych vs grupa kontrolna (K) z wyłączeniem grupy ALA10 oraz istotnie wyższe stężenie PSH w grupach OU+ALA10 i OU+ALA50 vs OU; wzrost stężenia nadtlenków lipidowych (lipid hydroperoxide – LHP) dla grup OU, OU+ALA10 i OU+ALA50 vs K z jednoczesnym obniżeniem stężenia LHP dla wszystkich grup badanych vs OU; wzrost stężenia dialdehydu malonowego (malondialdehyde – MDA) w grupie OU względem wszystkich pozostałych grup. Zaobserwowano także podwyższenie stężenia kreatyniny i mocznika w grupie OU. Wnioski Wykazano, że zastosowana dieta nasila proces peroksydacji lipidów oraz powoduje nasilenie utleniania grup sulfhydrylowych. Może także zaburzać czynność nerek. Podawanie z dietą kwasu liponowego w dawce 10 mg/kg mc. skutecznie hamuje proces peroksydacji lipidów oraz ochrania wolne grupy sulfhydrylowe. Med. Pr. 2017;68(3):391–399
Background Oils are often fried which reduces their beneficial biological and nutritional properties, contributing to disturbances in homeostasis. Some antioxidant substances can improve stability of oils. The aim of the study was to examine the effect of α-lipoic acid (ALA) on the concentration of sulfhydryl groups, lipid peroxides, malondialdehyde, creatinine and urea in serum of rats fed high fat diet for 3 months. Material and Methods Thirty six Wistar rats were equally divided into 6 groups: the control group on standard breeding diet (SB), oxidized oil (OU) group on SB with 10% oxidized oil, ALA10 group on SB with ALA 10 mg/kg of body weight (b.w.), OU+ALA10 group on SB with oxidized oil and ALA (10 mg/kg b.w.), ALA50 group on SB with ALA in a dose of 50 mg/kg b.w., OU+ALA50 group on SB with oxidized oil and ALA (50 mg/kg b.w.). Oil was oxidized in 180°C for 6 h. Results We observed decrease in concentration of protein sulfhydryl (PSH) groups in all study groups except for ALA10 vs. control group (C) and increase in OU+ALA10 and OU+ALA50 vs. OU; increase in the lipid hydroperoxide (LHP) concentration in OU, OU+ALA10 and OU+ALA50 vs. C and decrease in all study groups vs. OU; increase of malondialdehyde (MDA) in OU vs. all other groups. And also increase in creatinine and urea concentration in OU group. Conclusions High fat diet rich in oxidized oil intensifies the lipid peroxidation process and oxidation of sulfhydryl groups. It can also impair kidney function. Administration of lipoic acid in a dose of 10 mg/kg b.w. inhibits the lipid peroxidation and protects sulfhydryl groups. Med Pr 2017;68(3):391–399
Źródło:
Medycyna Pracy; 2017, 68, 3; 391-399
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of resistant starch RS4 added to the high-fat diets on selected biochemical parameters in Wistar rats
Autorzy:
Bronkowska, M.
Orzel, D.
Lozna, K.
Styczynska, M.
Biernat, J.
Gryszkin, A.
Zieba, T.
Kapelko, M.
Powiązania:
https://bibliotekanauki.pl/articles/872746.pdf
Data publikacji:
2013
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
resistant starch
RS4 starch
starch
high-fat diet
biochemical parameter
rat
Wistar rat
hepatic enzyme
enzyme activity
lipid metabolism
Opis:
Background. Resistant starch (RS) is part of potato starch that is not digested in the gastrointestinal tract. RS4 is a chemically modified starch (for example by oxidation and esterification) and physically (by heating). Objective. The study was aimed at determining the effect of resistant starch on lipid metabolism and activity of hepatic enzymes in Wistar strain rats fed high-fat diets containing 15% of lard or 15% of soybean oil. Material and methods. Four types of diets were administered to the animals (4 groups of males, n=32): control diet (K1) containing 15% of soybean oil; control diet (K2) containing 15% of lard as well as two groups receiving the same diets with 10% addition of resistant starch RS4 (K1S and K2S). Results. The mean concentration of total cholesterol was lower in the group of animals fed a diet with vegetable oil (39.9 mg/dl) as compared to that reported in the group of rats fed the lard-supplemented diet (55.2 mg/dl). Compared to the control groups in both groups of animals receiving the diet supplemented with resistant starch RS4 the total cholesterol concentration in serum decreased by ca. 25% (differences were statistically significant). In groups of rats receiving oil- or lard-containing diets with the addition of the resistant starch preparation the concentration of triglycerides in serum decreased by ca. 47% and 10%, respectively. Conclusions. A beneficial effect of the resistant starch RS4 added to Wistar rats diets on the lipid metabolism has been shown. The concentrations of total cholesterol and triglycerides in the serum were lower and concentration of HDL-cholesterol was higher in the rats fed with the diets containing the addition of the RS4 preparation as compared to the control groups. Based on the activity of hepatic enzymes the degree of liver damage was lower in groups of rats fed with diets containing resistant starch RS4 as compared to the control groups.
Wprowadzenie. Skrobia oporna (resistant starch, RS) jest to część skrobi ziemniaczanej, która w przewodzie pokarmowym nie ulega strawieniu. Skrobia oporna RS4 to skrobia modyfikowana chemicznie (np. przez oksydację lub estryfikację) oraz fizycznie (przez działanie termiczne). Cel. Celem badań była ocena wpływu skrobi opornej RS4 na gospodarkę lipidową oraz aktywność enzymów wątrobowych szczurów rasy Wistar karmionych dietami wysokotłuszczowymi zawierającymi 15% smalcu lub 15% oleju sojowego. Materiał i metody. Zwierzęta (4 grupy samców n=32) karmiono 4 rodzajami diet: kontrolną (K1) zawierającą 15% oleju sojowego i kontrolną (K2) zawierającą 15% smalcu oraz odpowiednio 2 grupy takich samych diet z 10% dodatkiem skrobi opornej RS4 (K1S i K2S). Wyniki. Średnie stężenie cholesterolu całkowitego w grupie zwierząt karmionych paszą z tłuszczem roślinnym było niższe (39,9 mg/dl) w porównaniu do odnotowanego w grupie szczurów karmionych dietą ze smalcem (55,2 mg/dl). W porównaniu do grup kontrolnych, w obu grupach zwierząt karmionych paszą zawierającą olej lub smalec z dodatkiem skrobi RS4 stężenie cholesterolu całkowitego w surowicy krwi obniżyło się o około 25% (różnice były istotne statystycznie). W grupach szczurów karmionych paszą z dodatkiem preparatu skrobi opornej RS4 stężenie triglicerydów w surowicy krwi obniżyło się odpowiednio o około 47% i 10%. Wnioski. Wykazano korzystny wpływ skrobi opornej RS4 dodawanej do diet szczurów Wistar na ich gospodarkę lipidową. Stwierdzono zmniejszenie stężenia cholesterolu całkowitego, TGC oraz zwiększenie stężenia cholesterolu HDL w surowicy krwi zwierząt otrzymujących diety z dodatkiem skrobi opornej RS4 w porównaniu do grup kontrolnych. Na podstawie aktywności enzymów wątrobowych stwierdzono niższy stopień uszkodzenia wątroby w grupach szczurów karmionych dietami z dodatkiem skrobi opornej RS4 w porównaniu do grup kontrolnych.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2013, 64, 1
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 13

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