Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "gene" wg kryterium: Wszystkie pola

  Lista filtrów

Dostawca treści

Podbaza

Wyrównaj
Wyświetlanie 1-25 z 1094
Tytuł:
Conceptualization of the Gene in Richard Dawkins’ The Selfish Gene
Autorzy:
Drogosz, Anna
Powiązania:
https://bibliotekanauki.pl/articles/2016189.pdf
Data publikacji:
2017
Wydawca:
Komisja Nauk Filologicznych Polskiej Akademii Nauk, Oddział we Wrocławiu
Tematy:
personification
blending
selfish gene
metaphor in science
Opis:
This paper investigates the conceptualization of the gene in the book The Selfish Gene by Richard Dawkins from the point of view of the Conceptual Metaphor Theory and the Conceptual Blending Theory. It is argued that there are two senses of the gene: gene1 is a physically existing section of the DNA, gene2 is information about protein synthesis. It is the second sense of the concept of the gene that undergoes metaphorization. The analysis reveals that Dawkins’ gene is a conceptual blend which becomes extensively elaborated. Through elaboration the gene becomes personified on the one hand and deified on the other. The study shows the richness of Dawkins’ personification: the gene is conceptualized as building and controlling organisms, cooperating and competing with other genes, even showing personality traits. Deification of the gene is focused on highlighting its stipulated immortality and power to create organisms, humans included. The gene blend is at the same time used as an input space in the integration network producing the meme blend. It is also established that the personification of the gene plays the theory-constitutive role in the sense of Boyd (1993).
Źródło:
Academic Journal of Modern Philology; 2017, 6; 75-84
2299-7164
2353-3218
Pojawia się w:
Academic Journal of Modern Philology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of single gene multitrait effects in livestock by the use of Gibbs sampling
Autorzy:
Dobek, A
Molinski, K.
Szydlowski, M.
Szwaczkowski, T.
Powiązania:
https://bibliotekanauki.pl/articles/2042024.pdf
Data publikacji:
2000
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
gene
gene frequency
major gene
livestock
Gibbs sampling
Źródło:
Journal of Applied Genetics; 2000, 41, 4; 275-283
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antiangiogenic gene therapy in inhibition of metastasis.
Autorzy:
Szala, Stanisław
Szary, Jarosław
Cichoń, Tomasz
Sochanik, Aleksander
Powiązania:
https://bibliotekanauki.pl/articles/1043756.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antiangiogenic gene therapy
encapsulation
inducible gene expression
metastasis
Opis:
This short review attempts to demonstrate the usefulness of antiangiogenic gene therapy in achieving inhibition of growth in experimentally-induced metastases. Certain normal tissues (for example skeletal muscle) may be used in vivo, after genetic modification, as a "bioreactor", able to produce and secrete into the bloodstream proteins known to exert antiangiogenic effects. By inhibiting neoangiogenesis these proteins would thus prevent the development of metastases. The review discusses also the perspectives of antimetastatic therapy based on certain types of allogenic cells (for example myoblasts and fibroblasts) that had been genetically modified and then microencapsulated. The strategy of encapsulation is aimed at protecting the modified cells secreting antiangiogenic factors from being eliminated by the immune system. Secretion of antiangiogenic proteins by these microencapsulated cells can be controlled with inducible promoters. Antiangiogenic genes remaining under the transcriptional control of such promoters may be switched on and off using antibiotics, such as tetracycline derivatives, or steroid hormones.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 313-321
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Data mining methods for gene selection on the basis of gene expression arrays
Autorzy:
Muszyński, M.
Osowski, S.
Powiązania:
https://bibliotekanauki.pl/articles/329803.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
gene expression array
gene ranking
feature selection
clusterization measures
fusion
SVM classification
ekspresja genów
selekcja cech
klasyfikacja SVM
Opis:
The paper presents data mining methods applied to gene selection for recognition of a particular type of prostate cancer on the basis of gene expression arrays. Several chosen methods of gene selection, including the Fisher method, correlation of gene with a class, application of the support vector machine and statistical hypotheses, are compared on the basis of clustering measures. The results of applying these individual selection methods are combined together to identify the most often selected genes forming the required pattern, best associated with the cancerous cases. This resulting pattern of selected gene lists is treated as the input data to the classifier, performing the task of the final recognition of the patterns. The numerical results of the recognition of prostate cancer from normal (reference) cases using the selected genes and the support vector machine confirm the good performance of the proposed gene selection approach.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2014, 24, 3; 657-668
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ensemble of data mining methods for gene ranking
Autorzy:
Wiliński, A.
Osowski, S.
Powiązania:
https://bibliotekanauki.pl/articles/201570.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
gene expression array
feature selection
gene ranking methods
classification
SVM
Opis:
The paper presents the ensemble of data mining methods for discovering the most important genes and gene sequences generated by the gene expression arrays, responsible for the recognition of a particular type of cancer. The analyzed methods include the correlation of the feature with a class, application of the statistical hypotheses, the Fisher measure of discrimination and application of the linear Support Vector Machine for characterization of the discrimination ability of the features. In the first step of ranking we apply each method individually, choosing the genes most often selected in the cross validation of the available data set. In the next step we combine the results of different selection methods together and once again choose the genes most frequently appearing in the selected sets. On the basis of this we form the final ranking of the genes. The most important genes form the input information delivered to the Support Vector Machine (SVM) classifier, responsible for the final recognition of tumor from non-tumor data. Different forms of checking the correctness of the proposed ranking procedure have been applied. The first one is relied on mapping the distribution of selected genes on the two-coordinate system formed by two most important principal components of the PCA transformation and applying the cluster quality measures. The other one depicts the results in the graphical form by presenting the gene expressions in the form of pixel intensity for the available data. The final confirmation of the quality of the proposed ranking method are the classification results of recognition of the cancer cases from the non-cancer (normal) ones, performed using the Gaussian kernel SVM. The results of selection of the most significant genes used by the SVM for recognition of the prostate cancer cases from normal cases have confirmed a good accuracy of results. The presented methodology is of potential use for practical application in bioinformatics.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2012, 60, 3; 461-470
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Novel isoforms of transcript of the EDA gene confirm X-linked inheritance of anhidrotic ectodermal dysplasia
Autorzy:
Kobielak, K
Kobielak, A.
Trzeciak, W.H.
Powiązania:
https://bibliotekanauki.pl/articles/2043606.pdf
Data publikacji:
1999
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dysplasia
inheritance
anhidrotic ectodermal dysplasia
Christ-Siemens-Touraine syndrome
Tabby gene
EDA gene
gene transcript
Źródło:
Journal of Applied Genetics; 1999, 40, 4; 355-364
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Properties of a Singular Value Decomposition Based Dynamical Model of Gene Expression Data
Autorzy:
Simek, K.
Powiązania:
https://bibliotekanauki.pl/articles/908156.pdf
Data publikacji:
2003
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
informatyka
multiple gene expression
singular value decomposition
dynamical model of gene expression data
Opis:
Recently, data on multiple gene expression at sequential time points were analyzed using the Singular Value Decomposition (SVD) as a means to capture dominant trends, called characteristic modes, followed by the fitting of a linear discrete-time dynamical system in which the expression values at a given time point are linear combinations of the values at a previous time point. We attempt to address several aspects of the method. To obtain the model, we formulate a nonlinear optimization problem and present how to solve it numerically using the standard MATLAB procedures. We use freely available data to test the approach. We discuss the possible consequences of data regularization, called sometimes "polishing", on the outcome of the analysis, especially when the model is to be used for prediction purposes. Then, we investigate the sensitivity of the method to missing measurements and its abilities to reconstruct the missing data. Summarizing, we point out that approximation of multiple gene expression data preceded by SVD provides some insight into the dynamics, but may also lead to unexpected difficulties, like overfitting problems.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2003, 13, 3; 337-345
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
SSCP polymorphism within 5 region of bovine lactoglobulin [LGB] gene
Autorzy:
Kaminski, S
Zabolewicz, T.
Powiązania:
https://bibliotekanauki.pl/articles/2044462.pdf
Data publikacji:
1998
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
lactoglobulin gene
polymorphism
SSCP method
cattle
gene transcription
electrophoresis
hormonal receptor
mutation
beta-lactoglobulin
milk
Opis:
In the paper the detection of the SSCP polymorphism within the 5’ fragment of bovine beta-lactoglobulin (LGB) gene is described. The 5’ fragment of LGB gene (209 bp) was PCR-amplified and then subjected to electrophoresis allowing the detection of SSCP polymorphism. Among 124 animals (50 cows and 74 bulls) six SSCP patterns were identified and named Rl, R2, R3, R4, R5 and R6, which occured with the frequency of 0.32, 0.51, 0.09, 0.06, 0.01 and 0.01, respectively. The PCR-SSCP method is simple, fast, and relatively inexpensive. The SSCP polymorphism reported in the paper may be useful in looking for the associations between different SSCP patterns and LGB gene expression and milk properties.
Źródło:
Journal of Applied Genetics; 1998, 39, 1; 97-102
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of phenobarbital on gene expression levels of p53 and DNMT1 in the liver of Wistar rats
Autorzy:
Urbanek-Olejnik, K.
Liszewska, M.
Kostka, G.
Powiązania:
https://bibliotekanauki.pl/articles/874211.pdf
Data publikacji:
2014
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
phenobarbital
gene expression
animal exposure
rat
p53 gene
Dnmt1 gene
liver
Wistar rat
Opis:
Background. Our previous studies have shown that short-term treatment with phenobarbital (PB) resulted in cytosine methylation of CpG sites on the p53 gene promoter in male Wistar rats’ liver. Furthermore, PB induced DNA-methyltransferases (DNMTs) activity was also demonstrated; being the enzymes that catalyze methyl group transfer to cytosine in CpG dinucleotides. Objective. Since DNA methylation is involved in regulating gene transcription and that DNMT1 is implicated in regulating DNA methylation, this study assessed whether PB-induced hypermethylation of the p53 promoter region was associated with an altered expression of p53 and Dnmt1 genes. Material and methods. Male Wistar rats received PB in three daily oral doses (at 24-h intervals) of 92,8 mg/kg b.w. x day-1. Levels of mRNA for p53 and Dnmt1 and levels of relevant proteins were respectively examined by Real-Time PCR and Western blot analysis. Results. Gene expression analysis revealed that exposure of Wistar rats to PB caused statistically significant alternations in the expression of tested genes. We found that both mRNA and protein expression of p53 was down-regulated, whereas expression of Dnmt1 (both mRNA and protein) was up-regulated after PB treatment. Conclusions. Suppression of p53 mRNA and protein expression, which is probably a result of epigenetic changes, (in particular aberrant p53 promoter hypermethylation), can be associated with tumour promoting activity of phenobarbital.
Wprowadzenie. Nasze wcześniejsze badania wykazały, że krótkoterminowe narażenie szczurów Wistar na fenobarbital (PB) stymulowało metylację cytozyny w badanych sekwencjach rejonu promotorowego genu p53. Ponadto stwierdzono wzrost aktywności metylotransferaz DNA (DNMT), enzymów które katalizują przenoszenie grupy metylowej do cytozyny w dinukleotydach CpG. Cel badań. Z uwagi że metylacja DNA pełni istotną rolę w ekspresji genów, a DNMT1 uczestniczy w regulacji metylacji DNA, w prezentowanych badaniach oceniano czy indukowana PB hipermetylacja rejonu promotorowego genu p53 była związana ze zmianami ekspresji genów p53 i Dnmt1. Materiał i metody. Samce szczurów szczepu Wistar otrzymywały PB w dawce 92,8 mg/kg m.c. x dzień-1, 3-krotnie w odstępach dobowych. Analizę poziomu transkryptów i białek badanych genów przeprowadzano odpowiednio metodą Real- -Time PCR i Western blot. Wyniki. W wyniku oddziaływania PB wykazano obniżoną ekspresję genu p53 i wzrost ekspresji metylotranserazy 1 (DNMT1). Wnioski. Supresja ekspresji p53 (na poziomie mRNA i białka) będąca prawdopodobnie wynikiem zmian epigenetycznych, w szczególności hipermetylacji jego rejonu promotorowego może być związana z promocyjną aktywnością fenobarbitalu.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2014, 65, 3
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Search for mouse gene related to GA733 human tumor antigen gene
Autorzy:
Zielewicz, J
Skrzypczak, M.
Wojcierowski, J.
Powiązania:
https://bibliotekanauki.pl/articles/2048195.pdf
Data publikacji:
1995
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
human antigen
glycoprotein
human genetics
mice
gene sequence
adenocarcinoma
cancer therapy
electrophoresis
carcinoma cell
bacteriophage
antigen
gene
mouse
oncoantigen
hybridization
tumour etiology
tumour
DNA
Opis:
Human antigen GA733-1, defined as 40 kDa cell glycoprotein, is one of the antigens associated with gastrointestinal carcinomas. Its studies may contribute to the tumor etiology and therapy effects in animal model.
Źródło:
Journal of Applied Genetics; 1995, 36, 3; 273-277
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Direct transfer of IL-12 gene into growing Renca tumors.
Autorzy:
Budryk, Magdalena
Wilczyńska, Urszula
Szary, Jarosław
Szala, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1044365.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
IL-12 gene
tumor gene therapy
naked DNA
Opis:
We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/ DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors causes a distinct therapeutic effect that depends on the time span between inoculation of mice with cancer cells and the beginning of the therapy. Therapy started on day 3 resulted in total cure (100%) of mice.
Źródło:
Acta Biochimica Polonica; 2000, 47, 2; 385-391
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Novel regulators of photosynthesis
Autorzy:
Leister, D.
Powiązania:
https://bibliotekanauki.pl/articles/80943.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
photosynthesis
chloroplast
gene expression
nuclear protein
nuclear gene
protein
thylakoid protein
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Involvement of plastid, mitochondrial and nuclear genomes in plant-to-plant horizontal gene transfer
Autorzy:
Sanchez-Puerta, M.V.
Powiązania:
https://bibliotekanauki.pl/articles/57778.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
angiosperm
plastid
mitochondrial genome
nuclear genome
genome
horizontal gene transfer
gene conversion
parasite
Opis:
This review focuses on plant-to-plant horizontal gene transfer (HGT) involving the three DNA-containing cellular compartments. It highlights the great incidence of HGT in the mitochondrial genome (mtDNA) of angiosperms, the increasing number of examples in plant nuclear genomes, and the lack of any convincing evidence for HGT in the well-studied plastid genome of land plants. Most of the foreign mitochondrial genes are non-functional, generally found as pseudogenes in the recipient plant mtDNA that maintains its functional native genes. The few exceptions involve chimeric HGT, in which foreign and native copies recombine leading to a functional and single copy of the gene. Maintenance of foreign genes in plant mitochondria is probably the result of genetic drift, but a possible evolutionary advantage may be conferred through the generation of genetic diversity by gene conversion between native and foreign copies. Conversely, a few cases of nuclear HGT in plants involve functional transfers of novel genes that resulted in adaptive evolution. Direct cell-to-cell contact between plants (e.g. host-parasite relationships or natural grafting) facilitate the exchange of genetic material, in which HGT has been reported for both nuclear and mitochondrial genomes, and in the form of genomic DNA, instead of RNA. A thorough review of the literature indicates that HGT in mitochondrial and nuclear genomes of angiosperms is much more frequent than previously expected and that the evolutionary impact and mechanisms underlying plant-to-plant HGT remain to be uncovered.
Źródło:
Acta Societatis Botanicorum Poloniae; 2014, 83, 4
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Helper-dependent adenoviral vectors in experimental gene therapy
Autorzy:
Józkowicz, Alicja
Dulak, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1041362.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
helper-dependent adenoviral vectors
adenoviruses
gene therapy
Opis:
In the majority of potential applications gene therapy will require an effective transfer of a transgene in vivo resulting in high-level and long-term transgene expression, all in the absence of significant toxicity or inflammatory responses. The most efficient vehicles for delivery of foreign genes to the target tissues are modified adenoviruses. Adenoviral vectors of the first generation, despite the high infection efficacy, have an essential drawback: they induce strong immune response, which leads to short term expression of the transgene, and limits their usefulness in clinical trials. In contrast, helper-dependent adenoviral vectors (HdAd) lacking all viral coding sequences display only minimal immunogenicity and negligible side-effects, allowing for long-term transgene expression. Thus, HdAd vehicles have become the carrier of choice for adenoviral vector-mediated experimental gene therapy, effectively used in animal models for delivery of transgenes into the liver, skeletal muscle, myocardium or brain. Strong and long-lasting expression of therapeutic genes has allowed for successful treatment of dyslipidemias, muscular dystrophy, obesity, hemophilia, and diabetes. Additionally, the large cloning capacity of HdAd, up to 37 kb, facilitates the use of physiologically regulated, endogenous promoters, instead of artificial viral promoter sequences. This enables also generation of the single vectors expressing multiple genes, which can be potentially useful for treatment of polygenic diseases. In this review we characterize the basic features of HdAd vectors and describe some of their experimental and potential clinical applications.
Źródło:
Acta Biochimica Polonica; 2005, 52, 3; 589-599
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A structural gene – evolving term and dilemmas
Autorzy:
Chorąży, Mieczysław
Powiązania:
https://bibliotekanauki.pl/articles/704374.pdf
Data publikacji:
2009
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
DNA
structural gene
RNA transcripts
non-protein coding RNA
“secondary” information
Opis:
The term “gene” was originally used as a purely theoretical concept. After discovery of DNA structure, and understanding the genetic code, the gene acquired a form of a distinct physical entity with its borders and specific signal sequences, having rather simple (as it was thought at that time) functions and relation to phenotype outcome. The term “structural gene” has been coined. The unique gene structure, and several unusual and omnipotent traits have been ascribed to the gene that resulted in the formulation of a “genocentric” theory as a basic expla nation of all features of living organisms. However, recent discoveries reveal a complex structure and functions of eukaryotic genes. It appears now that the coding sequences (exons) are spread out over extended regions (hundreds of thousands of kilobases) of DNA. The role of protein-non coding DNA sequences were recognized, and the new mechanisms controlling gene functions have been discovered. In addition, we acquired the knowledge about a powerful ability of the cell to interpret the information potential of genes, accordingly to the needs of a cell/organ or actual “context” and status of the dynamic systems operating within the cell. All these discoveries undermine the genocentric view of life. At this time any definition of “gene” seems to be inadequate with present knowledge, and one may ask again: what is a gene?
Źródło:
Nauka; 2009, 3
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ERF022 controls somatic embryogenesis in Arabidopsis via ethylene-related mechanism
Autorzy:
Nowak, K.
Gaj, M.D.
Powiązania:
https://bibliotekanauki.pl/articles/80300.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
gene encoding
transcription factor
somatic embryogenesis
ERF022 gene
Arabidopsis
expression pattern
tf gene
plant stress
ethylene biosynthesis
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association between RBMS1 gene rs7593730 and BCAR1 gene rs7202877 and Type 2 diabetes mellitus in the Chinese Han population
Autorzy:
Kazakova, Elena
Chen, Meijun
Jamaspishvili, Esma
Lin, Zhang
Yu, Jingling
Sun, Lulu
Qiao, Hong
Powiązania:
https://bibliotekanauki.pl/articles/1038363.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
type 2 diabetes mellitus
RBMS1 gene
BCAR1 gene
single nucleotide polymorphisms
SNPscan
Opis:
Two recent studies found that RBMS1 gene rs7593730 and BCAR1 gene rs7202877 are related to type 2 diabetes. However, the association of these loci with type 2 diabetes mellitus (T2DM) has not been examined in Chinese. We performed a replication study to investigate the association of the 2 susceptibility loci with T2DM in the Chinese population. We genotyped 1961 Chinese participants (991 with T2DM and 970 controls) for each of the 2 single nucleotide polymorphisms (SNPs) rs7593730 in RBMS1 and rs7202877 near BCAR1 using SNPscan and examined their association with T2DM using logistic regression analysis. We also analyzed the correlation of the SNP alleles and clinical phenotypes. In additive model, genotype association analysis of BCAR1 rs7202877 loci revealed that the homozygous of rs7202877 GG carriers had significantly decreased T2DM risk compared to homozygous carriers of TT (P=0.038, OR 0.44, 95% CI 0.20-0.96). In the recessive model, the GG genotype GG had significantly decreased T2DM risk compared to GT+TT (P=0.043, OR 0.67, 95% CI 0.46-0.99). Allele G was statistically significantly correlated with TC (mmol/L) (P=0.036) and LDL-C (mmol/L) (P=0.007). As for rs7593730, the carriers of CT and TT genotype had significantly decreased T2DM risk compared to the carriers of CC genotype (CT: CC P=0.038, OR 0.71, 95% CI 0.51-0.98; TT: CC P=0.010, OR 0.32, 95% CI 0.13-0.76). In a dominant model, TT+CT: CC (P=0.013, OR 0.673, 95% CI 0.49-0.92) and in a recessive model, TT: CT+CC (P=0.019, OR 0.59, 95% CI 0.39-0.92). The T allele carriers had significantly decreased T2DM risk compared to the carriers of C (P=0.002, OR 0.65, 95% CI 0.50-0.86). Allele T was statistically correlated with FINS (P=0.010). In conclusion, our study showed that RBMS1 gene rs7593730 and BCAR1 gene rs7202877 were significantly associated with type 2 diabetes in the Chinese population.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 377-382
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bounded Picard groups
Autorzy:
Abrams, Gene
Haefner, Jeremy
Powiązania:
https://bibliotekanauki.pl/articles/966672.pdf
Data publikacji:
1997
Wydawca:
Polska Akademia Nauk. Instytut Matematyczny PAN
Źródło:
Colloquium Mathematicum; 1997, 72, 2; 325-334
0010-1354
Pojawia się w:
Colloquium Mathematicum
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
More Acanthamoeba Genotypes: Limits to Use rDNA Fragments to Describe New Genotype
Autorzy:
Corsaro, Daniele
Powiązania:
https://bibliotekanauki.pl/articles/763668.pdf
Data publikacji:
2011
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
Acanthamoeba, genotype, full gene sequence, partial gene sequence
Opis:
Strains of the genus Acanthamoeba are usually assigned to sequence types or genotypes according to pair-wise similarity values of the nuclear gene for the small subunit of ribosomal RNA. This classification system was established by comparing full or nearly full gene sequences, > 2000 bp. For practical reasons, diagnostic fragments of smaller lengths have been identified and used for rapid and economic identification of large number of strains. While the use of these small fragments in diagnostics applications remains valid when and only if the reference full sequence-type is available, we contest their use to identify and describe new genotypes. We report herein the case of a new genotype described on the basis of solely a small partial sequence and discuss the poor reliability of this fragment to correctly infer phylogenetic relationships, and its limits in the description of new genotypes of Acanthamoeba.
Źródło:
Acta Protozoologica; 2011, 50, 1
1689-0027
Pojawia się w:
Acta Protozoologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic predisposition to breast and/or ovarian cancer – focus on the candidate BARD1 gene
Autorzy:
Klonowska, K.
Ratajska, M.
Wojciechowska, M.
Kozlowski, P.
Powiązania:
https://bibliotekanauki.pl/articles/80894.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
breast cancer
ovarian cancer
genetic predisposition
BRCA1 gene
structure
function
BARD1 gene
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2014, 95, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of dynamics of gene exspression using singular value decomposition
Autorzy:
Simek, K.
Kimmel, M.
Powiązania:
https://bibliotekanauki.pl/articles/332865.pdf
Data publikacji:
2002
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
wielokrotna ekspresja genów
dynamiczny model danych ekspresji genów
pojedynczy rozkład wartości
multiple gene expression
dynamic model of gene expression data
singular value decomposition
Opis:
Recently, data on multiple gene expression at sequential time points were analyzed, using Singular Value Decomposition (SVD) as a means to capture dominant trends, called characteristic modes, followed by fitting of a linear discrete-time dynamical model in which the expression values at a given time point are linear combinations of the values at a previous time point. We attempt to address several aspects of the method. To obtain the model we formulate a nonlinear optimization problem and present how to solve it numerically using standard MATLAB procedures. We use publicly available data to test the approach. Then, we investigate the sensitivity of the method to missing measurements and its possibilities to reconstruct missing data. Summarizing we point out that approximation of multiple gene expression data preceded by SVD provides some insight into the dynamics but may also lead to unexpected difficulties.
Źródło:
Journal of Medical Informatics & Technologies; 2002, 3; MI31-40
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of the suppressor gene of powdery mildew resistance gene Pm8 in common wheat [Triticum aestivum L.] cv. Regina
Autorzy:
Hanusova, R
Bartos, P
Zeller, F J
Powiązania:
https://bibliotekanauki.pl/articles/2046597.pdf
Data publikacji:
1997
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
yellow rust resistance
resistance gene Pm8
powdery mildew
wheat
suppressor gene
leaf rust resistance
Triticum aestivum
stem rust resistance
Opis:
The Czech winter wheat cv. Regina which does not possess specific genes for powdery mildew resistance except Pm5 was crossed with the cvs. Florida, Tjelvar, Agra, Olymp and Sabina, all possessing T1BL-1RS and the dominant suppressor SuPm8, with Riebesel 47/51 possessing substitution 1R-1B and SuPm8 and with the T1BL-1RS cvs. Sparta, Iris, Mona without SuPm8. Powdery mildew isolates avirulent on Pm8 and virulent on other Pm genes were used in the trials. Tests for resistance were carried out either on seedlings at the first leaf stage or on detached leaves cultured on benzimidazolagar. No segregation for resistant plants in F₂ of all crosses of the cv. Regina with cultivars possessing T1BL-1RS and SuPm8 indicates that Regina has SuPm8. The segregation ratio 3 resistant: 13 susceptible in the F₂ population of crosses between the cv. Regina and cultivars possessing T1BL-1RS and no SuPm8 also confirms the presence of SuPm8 in the cv. Regina. The obtained results also indicate that expression of Pm2 and Pm4b is not affected by SuPm8 and that SuPm8 does not affect stem rust resistance gene Sr31 located on 1RS segment.
Źródło:
Journal of Applied Genetics; 1997, 38, 1; 11-17
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gene patents – short report
Autorzy:
Waszkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/80750.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2014, 95, 4
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Involvement of the essential yeast DNA polymerases in induced gene conversion
Autorzy:
Hałas, Agnieszka
Ciesielski, Arkadiusz
Żuk, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1044442.pdf
Data publikacji:
1999
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
gene conversion
DNA polymerases
Saccharomyces cerevisiae
Opis:
In the yeast Saccharomyces cerevisiae three different DNA polymerases α, δ and ε are involved in DNA replication. DNA polymerase α is responsible for initiation of DNA synthesis and polymerases δ and ε are required for elongation of DNA strand during replication. DNA polymerases δ and ε are also involved in DNA repair. In this work we studied the role of these three DNA polymerases in the process of recombinational synthesis. Using thermo-sensitive heteroallelic mutants in genes encoding DNA polymerases we studied their role in the process of induced gene conversion. Mutant strains were treated with mutagens, incubated under permissive or restrictive conditions and the numbers of convertants obtained were compared. A very high difference in the number of convertants between restrictive and permissive conditions was observed for polymerases α and δ, which suggests that these two polymerases play an important role in DNA synthesis during mitotic gene conversion. Marginal dependence of gene conversion on the activity of polymerase ε indicates that this DNA polymerase may be involved in this process but rather as an auxiliary enzyme.
Źródło:
Acta Biochimica Polonica; 1999, 46, 4; 862-872
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Is there any mystery of ORPHANs?
Autorzy:
Cebrat, S
Dudek, M
Mackiewicz, P
Powiązania:
https://bibliotekanauki.pl/articles/2046624.pdf
Data publikacji:
1997
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
yeast
gene finding
DNA asymmetry
orphan
gene number
genome
Saccharomyces cerevisiae
Opis:
We have analysed the coding capacity of ORFs longer than 100 codons found in the yeast genome. Comparing the parameters describing the DNA asymmetry in the set of known genes and the set of all ORFs>100 codons we have found that there are about 4700 coding ORFs in the yeast genome. Since for more than 2300 ORFs recognisable functions have been already found and for about 2000 ORFs homology to known genes has been identified - only about 400 ORFs can be considered as orphans - ORFs without any known function or homology. This finding means that there is no mystery of orphans - a paradox showing that the fraction of orphans has been growing with the growing number of genes with known functions in the yeast genome.
Źródło:
Journal of Applied Genetics; 1997, 38, 4; 365-372
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-25 z 1094

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies