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Tytuł:
Wpływ substancji czynnych na własności reologiczne hydrożeli chitozanowych w pobliżu granicy przejścia fazowego zol-żel
Influence of active substances on rheological properties of chitosan hydrogels near sol-gel phase transition
Autorzy:
Owczarz, P.
Modrzejewska, Z.
Powiązania:
https://bibliotekanauki.pl/articles/2071912.pdf
Data publikacji:
2012
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
chitozan
hydrożele
reologia hydrożeli
matryce polimerowe
chitosan
hydrogel
rheology of hydrogels
polymeric network
Opis:
W pracy przedstawiono wyniki badań Teologicznych hydrożeli chitozanowych tworzących matrycę polimerową dla substancji czynnych. Jako substancje czynne stosowano albuminę wołową oraz wankomycynę. Inhibitorem przejścia fazowego zol-żel była zmiana temperatury roztworu. Wyznaczone własności reologiczne oraz krzywe temperaturowe roztworów wykazały, że w przypadku albuminy otrzymany roztwór zachowuje podobne własności jak wyjściowy roztwór chitozanu. W przypadku wankomycyny zainicjowany zmianą temperatury proces żelowania prowadzi do wytworzenia nieodwracalnej struktury.
Rheological properties of chitosan hydrogels forming polymeric network for active substances are presented in the paper. Bovine serum albumin and vancomycin were used as active substances. A change in solution tem-perature acted as an inhibitor of sol-gel phase transition. The determined rheological properties and temperature curves of solutions showed properties similar to those of initial chitosan solution. In case of vancomycin the gelation process initiated by a temperature change led to the formation of irreversible structure.
Źródło:
Inżynieria i Aparatura Chemiczna; 2012, 6; 364-365
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ promieniowania mikrofalowego oraz UV na właściwości hydrożeli chitozanowych
Influence of microwave and UV radiation on properties of chitosan hydrogels
Autorzy:
Bialik-Wąs, K.
Kudłacik, S.
Drabczyk, A.
Tyliszczak, B.
Powiązania:
https://bibliotekanauki.pl/articles/101311.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Stowarzyszenie Infrastruktura i Ekologia Terenów Wiejskich PAN
Tematy:
hydrożele
chitozan
Beetosan
promieniowanie UV
promieniowanie mikrofalowe
hydrogels
chitosan
UV radiation
microwave radiation
Opis:
W prezentowanym artykule porównano wpływ promieniowania mikrofalowego oraz UV na przebieg reakcji sieciowania hydrożeli chitozanowych. Syntezy prowadzono zarówno w oparciu o chitozan komercyjny, jak i Beetosan - chitozan pochodzący z pszczół z osypu zimowego oraz dla układów mieszanych chitozan - Beetosan. Otrzymane materiały hydrożelowe zostały poddane badaniom zdolności pęcznienia i badaniom inkubacyjnym w wodzie destylowanej oraz symulowanych płynach ustrojowych. Ponadto, dla wybranych układów określono morfologię powierzchni przy użyciu skaningowego mikroskopu elektronowego. Wyznaczono również kąty zwilżania θ metodą geometryczną poprzez naniesienie kropli cieczy na powierzchnię badanego materiału.
In this paper, the impact on microwave radiation and UV cross-linking of the course of reaction of obtaining chitosan hydrogels was presented. The synthesis were conducted using either commercial chitosan and Beetosan - chitosan derived from naturally died honeybees as well as using mixed systems containing both chitosan and Beetosan. The swelling capacity of obtained hydrogel materials as well as their tendency to degradation in distilled water and simulated body fluid have been tested. Moreover, morphology of the surface of selected samples using scanning electron microscope was characterized. Furthermore, the contact angles (θ) of attained materials were defined using geometrical method by applying a drop of liquid on the surface of the tested material.
Źródło:
Infrastruktura i Ekologia Terenów Wiejskich; 2016, II/2; 605-614
1732-5587
Pojawia się w:
Infrastruktura i Ekologia Terenów Wiejskich
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ ilości fotoinicjatora na właściwości i strukturę matrycy hydrożelowej
Effect of the photoinitiator amount on properties and structure of the hydrogel matrix
Autorzy:
Kudłacik, S.
Drabczyk, A.
Bialik-Wąs, K.
Tyliszczak, B.
Powiązania:
https://bibliotekanauki.pl/articles/101598.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Stowarzyszenie Infrastruktura i Ekologia Terenów Wiejskich PAN
Tematy:
hydrożele
fotopolimeryzacja
chitozan
fotoinicjator
absorpcja
stopień usieciowania
hydrogels
photopolymerization
chitosan
photoinitiator
adsorption
degree of crosslinking
Opis:
W pracy przedstawiono syntezę materiałów hydrożelowych metodą fotopolimeryzacji. Zsyntezowano szereg materiałów różniących się zawartością fotoinicjatora oraz przeprowadzono badanie zdolności pęcznienia i inkubację. Wykonano pomiar kątów zwilżania i analizę spektroskopową FT-IR. Na podstawie przeprowadzonych badań potwierdzono wpływ ilości fotoinicjatora na budowę materiału polimerowego. Zsyntezowane materiały cechowały się różną strukturą usieciowania, a co za tym idzie różnymi właściwościami. Możliwość modyfikacji struktury stwarza większe możliwości w zastosowaniach tych materiałów.
The paper presents a synthesis of the hydrogel materials by photopolymerization. A series of materials differing in the amount of photoinitiator was prepared. In these studies the ability of swelling of attained materials was determined. What is more, incubation studies were also carried out. Measurements of contact angles was conducted and a chemical structure of obtained materials was defined using FT-IR spectroscopy. On the basis of the research the impact on the amount of the photo-initiator on the structure of a polymeric material have been defined. Synthesized materials were characterized by a different degree of the cross-linking, and therefore they have different properties. Hence the conclusion that possibility of the structure modifying of the material creates more opportunities for its use.
Źródło:
Infrastruktura i Ekologia Terenów Wiejskich; 2016, II/2; 627-636
1732-5587
Pojawia się w:
Infrastruktura i Ekologia Terenów Wiejskich
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of the addition of collagen on the rheological properties of chitosan chloride solutions
Autorzy:
Owczarz, Piotr
Rył, Anna
Modrzejewska, Zofia
Dziubiński, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1034555.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
collagen
rheology
thermosensitive hydrogels
viscoelastic behaviour
Opis:
Colloidal solutions of chitosan of crab origin with the addition of collagen obtained from cowhide were studied. Were presents the influence of collagen concentration and the method of preparing the sample on the obtained mechanical properties of the solutions and the observed phase transition temperature. Rheological measurements were performed to determine the viscoelastic properties and phase transition temperatures of these solutions. The study was conducted in the temperature range of 5–60°C with the use of classical techniques of rotational rheometry in the cone-plate measurement system. A significant influence of a collagen addition to chitosan chloride solutions on the viscoelastic properties of the systems was observed. The addition of collagen in all the cases increased the sol–gel phase transition temperature in comparison with the chitosan chloride solution containing β-glycerophosphate.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 176-189
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of substrate composition on the physicochemical properties of hydrogels with chitosan
Autorzy:
Szcześniak, Maria
Grimling, Bożena
Meler, Jan
Pluta, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1034687.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Carbopl 934P
PVP
chitosane
hydrogels
pharmaceutical availability
rheological parameters
Opis:
The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene glycol-1,2 or polyethyleneglycol 400 and glycerol. Addition of polymers had positive influence on the dispersion of hydrogels. The studied gels have thixotropic properties, their viscosity increases with the increase of the concentration of polymers. Increase of the content of polyvinylpyrrolidone K 90 and Carbopol 934 P increases the consistence, gels are more firm and cohesive. Gels with 5 % chitosane, 15% polyvinylpyrrolidone K 90 and Carbopol 934 P in the presence of additives have prolonged half release period of hydrocortisone.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 187-191
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of selected polymers on the rheological properties of hydrogels with chitosan applied on the skin
Autorzy:
Szcześniak, Maria
Grimling, Bożena
Meler, Jan
Karolewicz, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1034591.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
hydrogels
pharmaceutical availability
rheological parameters
Opis:
The aim of the study was to evaluate the effect of methylcellulose and carboxymethylcellulose on the rheological properties of hydrogels applied to skin on chitosan in the presence of the additives propylene glycol and glycerol. Rheological studies showed that the tested gels are non-newtonian systems, and have thixotropic properties. Substrates made of methylcellulose and chitosan are characterised by higher shear values than those obtained with carboxymethylcellulose. The addition of polymers had a positive influence on the dispersion of hydrogels, and the addition of excipients increased firmness, consistency and cohesiveness of the gels. Larger increases were observed with the addition of 10% of glycol propylene and glycerol contents for methylcellulose and of 20% of carboxymethylcellulose.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 201-206
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The formation of hydrogels based on chitosan and its water-soluble derivatives
Autorzy:
Il’ina, Alla V.
Shagdarova, Balzhima Ts.
Lunkov, Alexey P.
Varlamov, Valery P.
Powiązania:
https://bibliotekanauki.pl/articles/1034059.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
crosslinking agent
gelation
hydrogels
quaternized chitosan
succinyl chitosan
Opis:
This review considers articles on the formation of hydrogels based on chitosan as well as succinylated and quaternized chitosan derivatives. They are synthesized using low toxicity reagents, under ordinary conditions (low production costs). Chitosan derivatives are soluble in an extended range of pH values and characterized by mucoadhesiveness, bioavailability and biodegradability, which extends the potential of their medical applications. One of the most important properties of chitosan and its derivatives is the ability to form hydrogels. Depending on the nature of the bonds that occur during formation, hydrogels are divided into chemically or physically crosslinked, or a mixture of the two. Chemically crosslinked gels have covalent bonds, while physically crosslinked gels are formed by noncovalent interactions, for example, ionic. Mixed hydrogels have both types of crosslinking.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 5-15
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of chitosan and carboxymethyl chitosan hydrogels by electron beam irradiation
Autorzy:
Czechowska-Biskup, Renata
Wach, Radosław
Stojek, Piotr
Kamińska, Martyna
Rosiak, Janusz M.
Ulański, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1034681.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
PEGDA
carboxymethyl chitosan
chitosan
hydrogel
radiation crosslinking
Opis:
Solutions of chitosan (CS) and carboxymethyl chitosan (CMCS) were subjected to irradiation by electron beam in presence of a crosslinking agent (poly(ethylene glycol) diacrylate - PEGDA) in order to produce carboxymethyl chitosan- and chitosan-based hydrogels. PEGDA macromonomer itself undergoes simultaneous polymerization and crosslinking either in neutral water or in acidic medium. Acidic solutions of chitosan of 0.5, 1 and 2% can be effectively crosslinked with PEGDA to form a gel. Although CMCS undergoes radiation-initiated crosslinking only at high concentration in water (over 10%), the presence of PEGDA in solution facilitated hydrogel formation even at lower concentration of CMCS. Formation of CS and CMCS hydrogels required irradiation doses lower than those needed for sterilization, i.e. 25 kGy, in some cases even as low as 200 Gy. Sol-gel analysis revealed relatively high gel fraction of obtained hydrogels, up to 80%, and good swelling ability. Both parameters can be easily controlled by composition of the initial solution and irradiation dose. Possible mechanisms of crosslinking reactions were proposed, involving addition of the polysaccharide macroradicals to a terminal double bond of PEGDA.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 27-45
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of bees’ chitosan based hydrogels containing Aloe vera
Autorzy:
Kudłacik-Kramarczyk, S.
Drabczyk, A.
Tyliszczak, B.
Powiązania:
https://bibliotekanauki.pl/articles/101614.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Stowarzyszenie Infrastruktura i Ekologia Terenów Wiejskich PAN
Tematy:
beetosan
chitosan
hydrogels
Aloe vera
bees
waste management
Opis:
Chitosan based hydrogels due to their specific properties and structure belong to the group of materials widely used in medicine. They are used as drug carriers with controlled release of active substances and in the preparation of innovative wound dressings. The main aim of the conducted research was the choice of the most favorable parameters for carrying the cross-linking reaction by means of UV radiation and microwaves. Subsequently, an adequate composition of the mixture containing chitosan and gelatin for further modification of such prepared the polymer matrix with Aloe vera extract was selected. Subsequently, an impact of introduction of Aloe vera extract into hydrogel on its physicochemical properties and structure was determined. The scope of the research included the measurement of swelling abilities of hydrogels in distilled water and selected simulated body fluids as well as incubation studies aimed at determination of tendency of prepared materials to degradation in previously mentioned fluids and their compatibility in relation to such environments. In order to characterize the chemical structure of the polymers and impact of incubation on this structure spectroscopic analysis was performed. Microscopic analysis was used to define the surface morphology of the hydrogels. Moreover, materials containing Aloe vera extract were subjected to the studies of release of additive from hydrogel matrix. Research was conducted both in acid and alkaline environment.
Źródło:
Infrastruktura i Ekologia Terenów Wiejskich; 2017, IV/2; 1687-1698
1732-5587
Pojawia się w:
Infrastruktura i Ekologia Terenów Wiejskich
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and potential cytotoxicity evaluation of carboxymethyl chitosan hydrogels
Autorzy:
Kłosiński, Karol K.
Girek, Małgorzata K.
Wach, Radosław A.
Czechowska-Biskup, Renata
Arkuszewski, Piotr T.
Szymański, Paweł B
Pasieka, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1034588.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
PEGDA
XTT
carboxymethyl chitosan
cytotoxicity
hydrogel
radiation crosslinking
Opis:
The aim of the research was to employ radiation to produce flexible carboxymethyl chitosan (CMCS) based hydrogels of uniform structure to characterise their swelling properties and cytocompatibility for potential applications as hydrogel wound dressings. CMCS in aqueous solution was irradiated with an electron beam in the presence of a poly(ethylene glycol) diacrylate (PEGDA) macromonomer as a crosslinker, at 12 different compositions, i.e. 3–20% CMCS, 3 and 5% PEGDA. The obtained hydrogels were subjected to sol–gel analysis. The amount of insoluble fraction (up to 100%) rose with an increase in the PEGDA/polysaccharide ratio. Moreover, the equilibrium degree of swelling, ca. 15 to 200 g of water per g of gel, which was higher for lower content of crosslinker, decreased with the delivered dose, which was associated with an increase in crosslinking density. The in vitro XTT cell viability assay (murine fibroblasts, L929 cell line) showed no significant cytotoxicity of CMCS gels.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 82-96
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of novel chitosan nanocomposite hydrogels for drug delivery and bone tissue engineering
Autorzy:
Pazdan, K.
Pielichowska, K.
Chłopek, J.
Powiązania:
https://bibliotekanauki.pl/articles/285119.pdf
Data publikacji:
2013
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanocomposites
tissue engineering
hydrogels
Opis:
Biodegradable materials for drug delivery and bone tissue engineering are currently intensively developing and improving, but there are still a lot of problems to solve related with bioactivity, biocompatibility, release profile etc. Osteosarcoma is an aggressive malignant neoplasm arising from primitive transformed cells of mesenchymal origin that exhibit osteoblastic differentiation and produce malignant osteoid. It is the most common histological form of primary bone cancer [1,2]. Treatment is most destinations and made up for: intensive multidrug short induction chemotherapy, amputation or tumor resection within the limits of normal tissue and in the last phase again chemotherapy. This kind of neoplasm is most recently detected in young male till 25 age, therefore improving methods of treatment is so important. Chitosan is a natural-based polymer obtained by alkaline deacetylation of chitin received from powdered shrimp shells was purchased from Acros Organics. Its main advantages are non-toxic, non-immunogenic, non-carcinogenic degradation products, biocompatible, bioactive and biodegradable. These properties cause chitosan a very good candidate for novel hydrogel drug delivery systems. Chitosan easily forms hydrogel particles and entraps biomolecules through a number of mechanisms, including chemical crosslinking, ionic crosslinking, and ionic complexation [3,4]. A possible alternative of chitosan by the chemical modification also has been useful for the association of bioactive molecules to polymer and controlling the drug release profile. There are few methods of modification, or example.: copolimerization, grafting, chemical and ionic crosslinking, polyelectrolyte complexes, etc [5]. Previous studies demonstrated that chitosan could promote the proliferation and osteogenesis but only with moderate swelling ratio of composite, too high ability of entrapment water solutions are not recommended. There are a lot of advantages in chitosan properties that can be used in research work to obtain the material of the best expected properties. Laponite® (LA) is a plate-like synthetic clay hectoritetype belongs to a family of phyllosolicates type 2:1 [6]. Its structure represent empirical formula: Na0.7+[Si8Mg5.5Li0.3 O20(OH)4]0.7-. The plates size is about 25 nm x 0,92 nm. LA has a large surface area, anionic surface charges and exchangeable Na+ cations in hydrated interlayers. Presence of sodium cations causes better adsorption properties for cationic drug molecules. Moreover, the exfoliated LA particles may act as multifunctional crosslinkers in forming the nanocomposite hydrogels, and the polymer chains were anchored to the particles and entangled to form a network [7]. Used synthetic clay has got the same type structure and but better sorption properties to montmorillonite but it has got serious advantage - as a synthetic compound shows low heavy metal content. The initial results indicate that the incorporation of clay improved the swelling behavior in contrast to the pure chitosan beads. There also had been revealed significant disproportion of viscosity received hydrogels according to different type of LA or different concentration. Increasing content causes telling rise of viscosity, especially reported in higher content of used crosslinker. The aim of research is to develop a bioactive system biopolymer/layered silicate intelligent nanocomposite based on chitosan and synthetic clay by a cross-linking reaction using sodium tripolyphosphate as the gel factor. The resultant composite were characterized by Fourier transform infrared spectroscopy, scanning electronic microscope and X-ray diffraction analysis. The bioactivity in physiological pH solution (SBF pH=7.40) [8], drug encapsulation efficiency and controlled release behaviour were also investigated by using the model drug to reveal the effects of introduced LA.
Źródło:
Engineering of Biomaterials; 2013, 16, no. 122-123 spec. iss.; 1-2
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural research of thermosensitive chitosan-collagen gels containing alp
Autorzy:
Skwarczyńska, Agata
Biniaś, Dorota
Modrzejewska, Zofia
Powiązania:
https://bibliotekanauki.pl/articles/1034675.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
alkaline phosphatase
chitosan
collagen
thermosensitive hydrogels
Opis:
Introducing collagen, which is basic ingredient of bone tissue, into the structure of chitosan gels which are formed at the physiological body temperature, is aimed at creating the so-called biomimetic structures, i.e. close in their composition to the natural composition of bone tissue. Within the research the influence of collagen on structural properties of thermosensitive chitosan gels and the influence of ALP on structural properties of chitosan and chitosan-collagen gels was determined.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 176-186
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural characteristics of thermosensitive chitosan glutaminate hydrogels
Autorzy:
Modrzejewska, Zofia
Nawrotek, Katarzyna
Zarzycki, R
Douglas, Timothz
Powiązania:
https://bibliotekanauki.pl/articles/1035319.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
hydrogel
natural polymer
structural properties
Opis:
Hydrogels that possess the ability of gelling in response to changes in the local environment, such as pH or temperature, have been examined extensively recently. In this paper the properties of thermosensitive chitosan hydrogels prepared with the use of chitosan glutaminate and -glycerophosphate are presented. The sol/gel transition point was determined based on the rheological properties. The structure of gels was observed under the Scanning Electron Microscopy (SEM) and was investigated by thermogravimetric (TG) and differential themogravimetric (DTG) analy¬sis and infrared (IR) spectroscopy. The crystallinity of gel structure was determined by X-ray Diffraction analysis (XRD).
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 93-105
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural and biological characteristics of self-organising chitosan hydrogels
Autorzy:
Pieklarz, Katarzyna
Tylman, Michał
Modrzejewska, Zofia
Galita, Grzegorz
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/2131528.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
biomaterials
chitosan
cytotoxicity
self-organising hydrogels
structural properties
tissue engineering
Opis:
Creating innovative methods of treatment and regeneration of damaged tissues or organs is a key challenge of the twenty-first century. The aim of this study was to determine the possibility of producing and characterising the properties of self-organising chitosan hydrogels prepared with the use of chitosan lactate/chloride and disodium hydrogen phosphate dodecahydrate as a cross-linking agent. The structure and supramolecular architecture of the biomaterials were evaluated by Fourier-transform infrared spectroscopy and polarised optical microscopy. Biological studies assessed cytotoxicity by contact with a human colon adenocarcinoma cell line. The colourimetric resazurin assay showed that the obtained chitosan hydrogels are non-cytotoxic materials. Thus, self-organising biomaterials hold great promise for application in tissue engineering.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 191-199
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rheological aspects of the flow of thermosensitive chitosan systems during injection application
Autorzy:
Rył, Anna
Owczarz, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1034161.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan scaffolds
injectability
thermosensitive hydrogels
Opis:
The aim of this paper was to conduct preliminary instrumental tests to determine the possibility of injection applications for thermosensitive chitosan systems, including injection needles and application conditions. Among the many biomedical and pharmaceutical applications of chitosan, the minimally invasive thermosensitive scaffolds that form in vivo are an interesting solution. Despite many studies on colloidal chitosan systems undergoing sol-gel phase transition, almost no studies have examined their injectability. It has been stated that the use of acetic acid as a solvent reduces the forces needed for injection. Moreover, the key impact of injection temperature was determined. Storing the medium at room temperature before the injectability test led to a decrease in the value of forces needed for injection. The obtained results are discussed based on the change of the rheological properties of the chitosan hydrogels.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 201-209
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 39

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